Sphingolipids and Metabolic Disease
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State...
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Sphingolipids and Metabolic Disease
ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY Editorial Board: NATHAN BACK, State University of New York at Buffalo IRUN R. COHEN, The Weizmann Institute of Science ABEL LAJTHA, N.S. Kline Institute for Psychiatric Research JOHN D. LAMBRIS, University of Pennsylvania RODOLFO PAOLETTI, University of Milan Recent Volumes in this Series Volume 712 CYSTEINE PROTEASES OF PATHOGENIC ORGANISMS Mark W. Robinson and John P. Dalton Volume 713 CELL FUSION IN HEALTH AND DISEASE, I: CELL FUSION IN HEALTH Thomas Dittmar Volume 714 CELL FUSION IN HEALTH AND DISEASE, II: CELL FUSION IN DISEASE Thomas Dittmar Volume 715 BACTERIAL ADHESION: BIOLOGY, CHEMISTRY AND PHYSICS Dirk Linke and Adrian Goldman Volume 716 MAST CELL BIOLOGY: CONTEMPORARY AND EMERGING TOPICS $ODVGDLU0*LO¿OODQDQG'HDQ'0HWFDOIH Volume 717 KAINATE RECEPTORS: NOVEL SIGNALING INSIGHTS Antonio Rodriguez-Moreno and Talvinder S. Sihra Volume 718 BRAIN INSPIRED COGNITIVE SYSTEMS 2010 Ricardo Sanz, Jaime Gomez and Carlos Hernandez Volume 719 HOT TOPICS IN INFECTION AND IMMUNITY IN CHILDREN VIII Nigel Curtis Volume 720 HUMAN CELL TRANSFORMATION Johng S. Rhim and Richard Kremer Volume 721 SPHINGOLIPIDS AND METABOLIC DISEASE L. Ashley Cowart
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Sphingolipids and Metabolic Disease Edited by L. Ashley Cowart, PhD Department of Biochemistry and Molecular Biology, Medical University of South Carolina, and Ralph H. Johnson Veteran’s Administration, Charleston, South Carolina, USA
Springer Science+Business Media, LLC Landes Bioscience
Springer Science+Business Media, LLC Landes Bioscience Copyright ©2011 Landes Bioscience and Springer Science+Business Media, LLC All rights reserved. 1RSDUWRIWKLVERRNPD\EHUHSURGXFHGRUWUDQVPLWWHGLQDQ\IRUPRUE\DQ\PHDQVHOHFWURQLFRUPHFKDQLFDO LQFOXGLQJSKRWRFRS\UHFRUGLQJRUDQ\LQIRUPDWLRQVWRUDJHDQGUHWULHYDOV\VWHPZLWKRXWSHUPLVVLRQLQZULWLQJ IURPWKHSXEOLVKHUZLWKWKHH[FHSWLRQRIDQ\PDWHULDOVXSSOLHGVSHFL¿FDOO\IRUWKHSXUSRVHRIEHLQJHQWHUHG DQGH[HFXWHGRQDFRPSXWHUV\VWHPIRUH[FOXVLYHXVHE\WKH3XUFKDVHURIWKHZRUN Printed in the USA. Springer Science+Business Media, LLC, 233 Spring Street, New York, New York 10013, USA http://www.springer.com Please address all inquiries to the publishers: Landes Bioscience, 1806 Rio Grande, Austin, Texas 78701, USA Phone: 512/ 637 6050; FAX: 512/ 637 6079 http://www.landesbioscience.com The chapters in this book are available in the Madame Curie Bioscience Database. http://www.landesbioscience.com/curie Sphingolipids and Metabolic Disease, edited by L. Ashley Cowart. Landes Bioscience / Springer Science+Business Media, LLC dual imprint / Springer series: Advances in Experimental Medicine and Biology. ISBN: 978-1-4614-0649-5 :KLOHWKHDXWKRUVHGLWRUVDQGSXEOLVKHUEHOLHYHWKDWGUXJVHOHFWLRQDQGGRVDJHDQGWKHVSHFL¿FDWLRQVDQGXVDJH RIHTXLSPHQWDQGGHYLFHVDVVHWIRUWKLQWKLVERRNDUHLQDFFRUGZLWKFXUUHQWUHFRPPHQGDWLRQVDQGSUDFWLFH DWWKHWLPHRISXEOLFDWLRQWKH\PDNHQRZDUUDQW\H[SUHVVHGRULPSOLHGZLWKUHVSHFWWRPDWHULDOGHVFULEHG LQWKLVERRN,QYLHZRIWKHRQJRLQJUHVHDUFKHTXLSPHQWGHYHORSPHQWFKDQJHVLQJRYHUQPHQWDOUHJXODWLRQV DQGWKHUDSLGDFFXPXODWLRQRILQIRUPDWLRQUHODWLQJWRWKHELRPHGLFDOVFLHQFHVWKHUHDGHULVXUJHGWRFDUHIXOO\ UHYLHZDQGHYDOXDWHWKHLQIRUPDWLRQSURYLGHGKHUHLQ
Library of Congress Cataloging-in-Publication Data Sphingolipids and metabolic disease / edited by L. Ashley Cowart. p. ; cm. -- (Advances in experimental medicine and biology ; v. 721) ,QFOXGHVELEOLRJUDSKLFDOUHIHUHQFHV ISBN 978-1-4614-0649-5 1. Sphingolipidoses. 2. Sphingolipids--Pathophysiology. I. Cowart, Lauren Ashley. II. Series: Advances in experimental medicine and biology ; v. 721. 0065-2598 [DNLM: 1. Metabolic Diseases--pathology. 2. Sphingolipids--metabolism. W1 AD559 v.721 2011 / WD 200] RC632.S67S64 2011 616.3’9--dc23 2011021157
PREFACE
5HFHQW\HDUVKDYHZLWQHVVHGDQH[SORVLRQLQWKHLQFLGHQFHRIREHVLW\DQGLWVVHTXHODH LQFOXGLQJ7\SH GLDEHWHV DQG WKH PHWDEROLF V\QGURPH:KLOH RULJLQDOO\ FRQILQHG WR developed countries, increasing prosperity in developing countries has broadened the ZRUOGZLGHLQFLGHQFHRIWKHVHGLVRUGHUV0RUHRYHUZKLOHGLDJQRVHVRI7\SHGLDEHWHV ZHUHRULJLQDOO\DOPRVWH[FOXVLYHO\FRQILQHGWRDGXOWSRSXODWLRQVWKHULVHLQFKLOGKRRG REHVLW\KDVSUHFLSLWDWHGDPDUNHGLQFUHDVHRIWKLVGLVRUGHULQFKLOGUHQ7KXVLWLVFUXFLDO to explore all possible therapeutic and preventive methods to attenuate pathological processes associated with these disorders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sphingolipids in these disease processes. Chapter 1: Sphingolipid Metabolism and Analysis in Metabolic Disease, by Sarah ( %ULFH DQG /$VKOH\ &RZDUW 7KLV FKDSWHU SUHVHQWV DQ RYHUYLHZ RI VSKLQJROLSLG PHWDEROLVP DQG LWV UHJXODWLRQ IROORZHG E\ FDYHDWV DQG WHFKQLFDO FRQVLGHUDWLRQV IRU sphingolipid measurement. Chapter 2: Sphingolipids and Cardiovascular Diseases, by Xian-Cheng Jiang, Ira -*ROGEHUJDQG7DH6LN3DUN7KLVFKDSWHUDGGUHVVHVFXUUHQWNQRZOHGJHRIWKHUROHV RI VSKLQJROLSLGV LQ G\VIXQFWLRQ RI WKH FDUGLRYDVFXODU V\VWHP LQFOXGLQJ OLSRSURWHLQ metabolism, atherosclerosis, and cardiomyopathy. Chapter 3: Heart Sphingolipids in Health and Disease, by Marcin Baranowski and Jan Górski. This chapter continues the cardiovascular theme by addressing novel v
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PREFACE
PHFKDQLVPVRIUHJXODWLQJVSKLQJROLSLGELRV\QWKHVLVLQWKHKHDUWLQGLDEHWHVDVZHOODV WKHSURWHFWLYHUROHRIVSKLQJROLSLGVLQLVFKHPLDUHSHUIXVLRQLQMXU\ Chapter 4: Blood Sphingolipids in Homeostasis and Pathobiology, by Samar M. +DPPDG 7KLV FKDSWHU DGGUHVVHV WKH FOLQLFDO DVVHVVPHQW RI EORRG VSKLQJROLSLGV IRU diagnostic purposes. Chapter 5: Adipose Tissue and Ceramide Biosynthesis in the Pathogenesis of Obesity, by Fahumiya Samad, Leylla Badeanlou, Charmi Shah, and Guang Yang. This chapter GLVFXVVHVFKDQJHVLQVSKLQJROLSLGVWKDWRFFXUDVDUHVXOWRIREHVLW\DQGKRZWKHVHFKDQJHV PHGLDWHLQIODPPDWLRQDQGFDUGLRYDVFXODUULVN Chapter 6: Sphinoglipids and Hepatic Steatosis,E\%HQMDPLQ7%LNPDQDQG6FRWW $ 6XPPHUV 7KLV FKDSWHU GLVFXVVHV KRZ PDQLSXODWLRQ RI VSKLQJROLSLG PHWDEROLVP LQIOXHQFHVWULDF\OJ\OHUROPHWDEROLVPLQWKHFRQWH[WRIIDWW\OLYHU Chapter 7: Glycosphingolipids and Insulin Resistance, by Johannes M. Aerts and FROOHDJXHV7KLVFKDSWHUGLVFXVVHVWKHUROHVRIJO\FRVSKLQRJOLSLGVLQLQVXOLQVLJQDOLQJDQG KRZSKDUPDFRORJLFDOUHGXFWLRQRIJO\FRVSKLQRJOLSLGV\QWKHVLVDPHOLRUDWHVV\PSWRPV RIWKHPHWDEROLFV\QGURPH Chapter 8: Glycosphingolipids and Kidney Disease, by Andrew R. Mather and /HDK - 6LVNLQG7KLV FKDSWHUFRQWLQXHV D IRFXV RQ JO\FRVSKLQJROLSLGV LQ WKH FRQWH[W RINLGQH\SDWKRORJ\$OWKRXJKWKHLPSOLFDWLRQRIJO\FRVSKLQJROLSLGVLQNLGQH\GLVHDVH DVVRFLDWHGZLWKGLDEHWHVLVVWLOOFRQMHFWXUDOWKHUROHWKHVHOLSLGVSOD\LQDVSHFWUXPRI NLGQH\GLVRUGHUVDVGLVFXVVHGLQWKLVFKDSWHUMXVWLILHVIXUWKHULQYHVWLJDWLRQLQWKLVKLJKO\ novel and underexplored area. Chapter 9: Sphingolipid Synthetic Pathways are Major Regulators of Lipid HomeostasisE\7LOOD6:RUJDOO7KLVILQDOFKDSWHUSUHVHQWVFRPSHOOLQJILQGLQJVWKDW VSKLQJROLSLGVPD\UHJXODWHFKROHVWHUROKRPHRVWDVLVWKURXJK65(%3DQGOLSLGHIIOX[7KH cross-talk between sphingolipids and lipoprotein metabolism presents rich opportunities IRUWKHUDSHXWLFVDLPHGDWDPHOLRUDWLQJG\VOLSLGHPLDDVVRFLDWHGZLWKPHWDEROLFV\QGURPH that promotes atherosclerosis. 2XU JRDO LQ WKLV YROXPH ZDV WR FRPSLOH FKDSWHUV SUHVHQWLQJ EURDG RYHUYLHZV RI WLVVXHVSHFLILFHIIHFWVRIVSKLQJROLSLGVZKLOHHPSKDVL]LQJLQWHUUHODWHGQHVVRIFHOOXODU processes and cross-talk between organs. :HKRSH\RXHQMR\WKHYROXPH L. Ashley Cowart, PhD Department of Biochemistry and Molecular Biology, Medical University of South Carolina, and Ralph H. Johnson Veteran’s Administration, Charleston, South Carolina, USA
ABOUT THE EDITOR...
L. ASHLEY COWARTREWDLQHGKHU%6LQ%LRORJ\LQIURP)XUPDQ8QLYHUVLW\ LQ*UHHQYLOOH6RXWK&DUROLQDDQGKHU3K'LQ%LRFKHPLVWU\LQIURP9DQGHUELOW 8QLYHUVLW\ LQ 1DVKYLOOH 7HQQHVHH$IWHU SRVWGRFWRUDO ZRUN LQ WKH ODERUDWRU\ RI 'U <XVXI+DQQXQVKHMRLQHGWKHIDFXOW\DWWKH0HGLFDO8QLYHUVLW\RI6RXWK&DUROLQDLQ &KDUOHVWRQ6RXWK&DUROLQDZKHUHVKHFXUUHQWO\KROGVWKHSRVLWLRQRI$VVLVWDQW3URIHVVRU RI%LRFKHPLVWU\DQG0ROHFXODU%LRORJ\'U&RZDUW¶VPDLQUHVHDUFKIRFXVLVWKHUHJXODWLRQ RI VSKLQJROLSLG PHWDEROLVP LQ GLDEHWHV DQG REHVLW\ DQG WKH UROHV RI VSKLQJROLSLGV LQ pathological outcomes associated with these disorders. In addition to research, she is involved with graduate admissions and education.
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PARTICIPANTS
Johannes M. Aerts Academic Medical Center 'HSDUWPHQWRI0HGLFDO%LRFKHPLVWU\ 8QLYHUVLW\RI$PVWHUGDP Amsterdam The Netherlands
1RUD%LMO Academic Medical Center 'HSDUWPHQWRI0HGLFDO%LRFKHPLVWU\ 8QLYHUVLW\RI$PVWHUGDP Amsterdam The Netherlands
Jan Aten Academic Medical Center 'HSDUWPHQWRI3DWKRORJ\ 8QLYHUVLW\RI$PVWHUGDP Amsterdam The Netherlands
%HQMDPLQ7%LNPDQ Program in Cardiovascular and Metabolic Disorders Duke-NUS Graduate Medical School Singapore
Leylla Badeanlou 7RUUH\3LQHV,QVWLWXWHIRU0ROHFXODU Studies 6DQ'LHJR&DOLIRUQLD USA Marcin Baranowski 'HSDUWPHQWRI3K\VLRORJ\ 0HGLFDO8QLYHUVLW\RI%LDá\VWRN %LDá\VWRN Poland Florence M. Bietrix Academic Medical Center 'HSDUWPHQWRI0HGLFDO%LRFKHPLVWU\ 8QLYHUVLW\RI$PVWHUGDP Amsterdam The Netherlands
5ROI*%RRW Academic Medical Center 'HSDUWPHQWRI0HGLFDO%LRFKHPLVWU\ 8QLYHUVLW\RI$PVWHUGDP Amsterdam The Netherlands Sarah E. Brice 'HSDUWPHQWRI%LRFKHPLVWU\ and Molecular Biology 0HGLFDO8QLYHUVLW\RI6RXWK&DUROLQD Charleston, South Carolina USA L. Ashley Cowart 'HSDUWPHQWRI%LRFKHPLVWU\ and Molecular Biology 0HGLFDO8QLYHUVLW\RI6RXWK&DUROLQD and Ralph H. Johnson Veteran’s Administration Charleston, South Carolina USA ix
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PARTICIPANTS
Nick Dekker Academic Medical Center 'HSDUWPHQWRI0HGLFDO%LRFKHPLVWU\ 8QLYHUVLW\RI$PVWHUGDP Amsterdam The Netherlands
Samar M. Hammad 'HSDUWPHQWRI5HJHQHUDWLYH0HGLFLQH and Cell Biology 0HGLFDO8QLYHUVLW\RI6RXWK&DUROLQD Charleston, South Carolina USA
0DUFRYDQ(LMN Academic Medical Center 'HSDUWPHQWRI0HGLFDO%LRFKHPLVWU\ 8QLYHUVLW\RI$PVWHUGDP Amsterdam The Netherlands
Xian-Cheng Jiang 'HSDUWPHQWRI&HOO%LRORJ\ 6WDWH8QLYHUVLW\RI1HZ