QIMP-15

Section - I 'Ghaptei-t '" �� 'GASTR.(j�lNIfESTINAri :"60mVmin, If recommended dose is 160mg twice daily; if creatinin...

Author: Dr. Ridwan Ullah Shahidi

637 downloads 5766 Views 34MB Size Report

This content was uploaded by our users and we assume good faith they have the permission to share this book. If you own the copyright to this book and it is wrongfully on our website, we offer a simple DMCA procedure to remove your content from our site. Start by pressing the button below!
Report copyright / DMCA form

DOWNLOAD PDF

Section - I

'Ghaptei-t '" �� 'GASTR.(j�lNIfESTINAri :"60mVmin,

If

recommended dose is 160mg twice daily; if creatinine clearance between 40 and 60mVmin, the dose is 160mg once daily. In patients with creatinine clearance less than 40mVmin, sotalol is contraindicated. Drug inter: In combined therapy, clonidine should not be discontinued until several days after withdrawal of sotalol. Use with great caution with drugs that also prolong QT interval, e.g disopyramide, amiodarone, class-I antiarrhythmic agents, calcium antagonists of the verapamil type or tricyclic antidepressants. Interactions also occur with phenothiazines. terfenadine. astemizole and diltiazem. Concomitant use of reserpine, guanethidine, or alpha methyldopa requires close monitoring for evidence of hypotension and/or marked bradycardia, syncope. Hypoglycemia may occur

.:. SOTALEX·80 Tab. UniMed Pharma

OTHER BETA·BLOCKERS- As anti arrhythmic drug, see under antihypertensive drugs (later).

OTHER PREPNS. CARDIAC GLYCOSIDES- As anti arrhythmic drugs, see under cardiac glycosides.

See under calcium channel blocker.

Mode of action: Clonidine hydrochloride stimulates alpha-adrenoreceptors in the barin stem. This action results in reduced sympathetic outflow from the central nervous system and in decreased in peripheral resistance, renal vascular resistance, heart rate, and blood pressure.

Ind: Clonidine is indicated in multiple uses: i, Hypertensive urgencies, resistant hypertension and atrial fibrillation; ii. For the treatment of attention deficit hyperactivity disorder- ADHD (is characterized by behavioral and learning disorder); iii. Autism, (a development disturbance, characterized by an abnormal or impaired development in social communications

daily. Rapid digitalization, 0.75-1.5mg

and interaction skills and significantly restricted

followed by 0,25mg. 6 hourly until ventricular

range of activities and interests); iv, Tourelte's

rate 70-80/min.

syndrome, (a neurological disorder in which the

Child: Under 10 years, digitalization

major symptom is tics which are sudden, brief,

10-20 mcglkg body-wt. 6 hourly; maintenance,

involuntary movements or sounds); v. For growth

ususally 10-20 mcglkg body-wt. daily in single

retardation, (c1onidine has been reported to be a

or divided doses.

stimulant of growth hormone release, presumably

:. AGOXIN Tab. Aristopharma Digoxin 0.25mg/tablet.

Opioid detoxification.

1 00's pack: 1 09.00 MRP

CIl: Any hypersensitivity to clonidine.

.:. CENTOXIN Tab. Opsonin Digoxin 0.25mg/tablet.

diminish with continued therapy, The most

•

as a result of central alpha adrenergic stimulation); vi. Menopausal hot flash; and vii .

SIE: Most adverse effects are mild and tend to

50's pack: 54.50 MRP

frequent adverse effects (which appear to be dose

.:. CENTOXIN Elixir Opsonin

related) are dry mouth, drowsiness, dizziness,

60ml bot: 75.00 MRP

effects are headache, with-drawal syndrome,

Digoxin 0.25mg/5ml: syrup.

.:. DIGOXEN Soft Cap. Drug Inter.

constipation and sedation. Less frequent adverse tachycardia, bradycardia, depression,

Digoxin USP O. l mg & 0.2mg/capsule (soft).

nervousness, anxiety, restlessness, urticaria, urine

0 . 1 mg x 100's pack: 94.00 MRP

retention etc,

Q,2mg x 50's pack: 67.00 MRP

Pregnancy & lactation: No adequate, well

.:. LANOXIN Tab. GlaxoSmithKline

controlled stuides have been conducted in

100's pack: 236.00 MRP

pregnancy only if clearly needed. As clonidine is

Digoxin 0.25mg/tablet.

3. ANTIHYPERTENSIVE DRUGS

pregnant women. So, it should be used during excreted in human milk, caution should be exercised when it is administered to nursing mother.

Dosage & admin: i. Hypertensive urgencies, O.lmg twice daily to manage the hypertensive crisis than tailing off the therapy; resistant

3.1 Centrally acting antihypertensive drugs

hypertension, O.lmg twice daily; atrial

3.2 Ganglion (sympathetic) blocking drugs

fibrillation, 0.075mg once or twice daily alone

3.3 Adrenergic neurone blocking drugs

or with digoxin; ii. For the treatment of

3.4 Beta adrenoceptor blocking drugs

attention deficit hyperactivity disorder

3.5 Alpha adrenoceptor blocking drugs

(ADHD), 5mcglkglday. iii. Autism, 0.15mg to

3.6 Drugs affecting the renin-angiotensin

0.2mglday. iv, Tourette's syndrome, 150-

system

200mcglday. v. For growth retardation, 37.5-

3.7 Vasodilator antihypertensive drugs

150mcglm2/day. vi. Menopausal hot flash,

3.S Drugs acting on blood volume: diuretics

O.lmg to O.4mg daily for up to 2 weeks.

3.9 Misc preparations:

Drug inter: Clonidine may potentiate CNS

i. Non-classified preparations VERAPAMIL: Tablet

Clonidinedrochloride USP 0 . 1 mg and 0.3mg/tablet.

O.25-0.75mg daily; maintenance 0.25-0.5mg

Sotalol hydrochloride USP 80mgltablet. 30's pack: 240.00 MRP

.:. CATAPRES Tab. Navana

Dosage & admin: Adult: Slow digitalization,

and the dosage of insulin or antidiabetic drugs may require adjustment.

CLONIDINE78

depressive effect of alcohol, barbiturates or other

ii. Combined antihypertensive

sedative drugs. Hypotensive effect may be

preparations

reduced if a patient receives c10nidine and

QIMP-15 (34)

CARDIOVASCULAR SYSTEM

tricyclic anti-depressant, where increased dose of clonidine is required. Due to a potential for additive effects (such as bradycarida &A.V block) caution is warranted in patients receiving clonidine concomitantly with agents (e.g digitalis, calcium channel blockers & -blockers) known to affect sinus node function or A. V nodal conduction. O. l mg x 50's pack: l 50.00 IP

METHYLDOPA21.33 METHYLDOPA: Tablet! Capsule! Injection. Ind: All grades of hypertension, inconjunction with a diuretic; hypertensive crisis. CII: History of depression, active liver disease, phaeochromocytoma. Renal impairment. Anaesthesia. SIE: Sedation, headache, asthenia, depression, bradycardia, nasal congestion, dry mouth, G. l upset. Positive coombs test, jaundice, haemolytic anaemia. Dose: Adult, initially, 250 mg 2 or 3 times daily iucreased to max. 3gm daily adjust at two day intervals. Child, initially 10mglkg body-wt. daily in 2-4 divided doses. .:. DOPEGYT Tab. Ambee

Methyldopa 250mg/tablet. 100's pack: 308.00 MRP

.:. SARDOPA Tab. Incepta

Methyldopa 250mg/tablet. 50's pack: 154.00 MRP

Ganglion (sympathetic) blocking drugs21 In this group the only drug used to reduce hypertension was Trimetaphan. , Now a day, it is not used therapeutically.

Adrenergic neurone blocking drugs2l The only member of adrenergic neurone blocking (i.e inhibiting the release of noradrenaline from postganglionic adrenergic neurones) agents that used as antihypertensive drug is Guanethidine. But, due to some limitations and adverse effects such as, failure to control supine blood pressure and causing postural hypotension, its use has become very much restricted.

Beta-adrenoceptor blocking drugs Beta-adrenoceptor blocking drugs (beta-blockers) are effectively used in the treatment of hypertension. They act by blocking the beta adenoceptors in the heart, peripheral vasculature, bronchi, pancreas, and liver. These drugs include:

Propranolol, Acebutolol, Atenolol, Bisoprolol, Carvedi/ol, Celiprolol, Esmolol, Labetalol,

the slow heart rate, the dose may be reduced. Propranolol modifies the tachycardia, of hypoglycaemia. Caution should be exercised in the concurrent use of propranolol and hypoglycaemic therapy in diabetic patients. Propranolol may prolong the hypoglycaemic response to insulin.

MetoproIoI, NadoloI, NebivoloI, OxprenoloI, Pindolol, Sotalol & Timolol.

PROPRANOLOV l ,48.52 PROPRANOLOL HCl: Tablet!Capsule/ Injection.

�l

Propranolol hydrochloride is a selective blocker. Mode of action: Propranolol, as a selective blocker, it blocks the effects of adrenergic stimulation mediated through these receptors. The cardio-selectivity is dose-related. Propranolol causes a reduction in blood pressure by lowering cardiac output, decreasing the plasma renin activity and sympathetic outflow from CNS. Propranolol also causes a reduction in myocardial oxygen demand by virtue of its negative inotropic and negative chronotropic effects. Ind: Propranolol is indicated in- i. the control of essential and renal hypertension, ii. the management of angina pectoris, iii. the long term prophylaxis after recovery from acute myocardial infarction, iv. the control of most forms of cardiac arhythmia, v. the prophylaxis of migraine, vi. the management of essential tremor, vii. the control of anxiety and anxiety tachycardia, viii. the adjunctive management of thyrotoxicosis and thyrotoxic crisis, ix. management of hypertrophic obstructive cardiomyopathy, x. management of phaeochromocytoma (with an alpha blocker). CII: Propranolol should not be used in the presence of- i. second or third degree heart block, ii. cardiogenic shock, iii. history of bronchospasm, iv. after prolonged fasting, v. metabolic acidosis (e.g in some diabetics), vi. several peripheral vascular disease (including intermittent claudication), vii. sick sinus syndrome, viii. uncontrolled heart failure, ix. hypotension, x. untreated phaeocromocytoma, xi. Prinzmetal1s angina. SIE: Pronounced fatigue and cold extremities have been observed in 10-20% of the treated subjects. Complaints about bradycardia, dizziness and gastrointestinal symptoms are less frequent. Despite its relative selectivity, atenolol can cause bronchospasms in asthma patients. Rarely observed side-effects are sleep disturbances, depression, paresthesiae, impotence, exanthema, psoriasis exacebations and arthropathies. Clinically relevant changes in the blood sugar have hardly occurred. There is no clarity as to the practical significance of the above mentioned changes in the lipid metabolism. Precautions & warnings: Special care should be taken with patients whose cardiac reserve is poor. Beta-adrenoceptor blocking drugs should be avoided in overt heart failure. However, they may be used in patients whose signs of failure have been controlled. Heart failure due to thyrotoxicosis often responds to propranolol alone, but if other adverse factors co-exist myocardial contractility must be maintained and signs of failure controlled with digitalis and diuretics. One of the pharmacological actions of propranolol is to reduce heart rate. In the rare instance when symptoms may be attributable to

�l

In patients suffering from ischaemic heart disease, as with other beta-blocking agents, treatment should not be discontinued abruptly. Either the equivalent dosage of another beta blocker may be substituted or the withdrawal of propranolol should be gradual. Care should be taken in the parenteral administration of preparations containing adrenaline to patients taking beta-blocking drugs as, in rare cases, vasoconstriction, hypertension and bradycardia may result. Caution should be exercised when transferring patients from clonidine to beta-blocker. If beta blockers and clonidine are given concurrently, clonidine should not be discontinued until several days after withdrawal of the beta-blocker (see also prescribing information on clonidine). Care should be taken in prescribing a beta blocker with class 1 antidysrhythrnic agents such as disopyramide. Beta-blockers should be used with caution in combination with verapamil in patients with impaired ventricular function. The combination should not be given to patients with conduction abnormalities. Neither drug should be administered intravenously within 48 hours of discontinuing the other. Anaesthesia: It is not advisable to withdraw beta blockers prior to surgery in the majority of patients. However. care should be taken when using anaesthetic agents such as ether, cyclopropane and trichloroethylene. Vagal dominance, if it occurs, may be corrected with atropine ( l -2mg i.v). Pregnancy & lactation: As with all other drugs, it should not be given in pregnancy unless its use is essential. There is no evidence of teratogenicity with propranolol. Dosage & admin: By mouth: Adult Hypertension, initially 80mg twice daily increasing if necessary at weekly intervals to 160-320 mg daily_ Anxiety, 40mg 2·3 times daily increasing if necessary at weekly interval upto 120-l40mgi day. Phaeochromocytoma, 60mg daily with an alpha-blocker for 3 days preoperatively or 30mg daily in inoperable case. Arrythmias, hypertrophic obstructive cardiomyopathy, anxiety tachycardia and thyrotoxicosis- 10-40mg 3-4 times daily. Anxiety with symptoms such as palpitations, sweating, tremor etc., 40mg 2-3 times daily. Child: 0.25-0'5mglkg body-Wt. 3 or 4 times daily_

By intravenous injection: lmg over 1 minute, preceded by atropine sulphate 1-2 mg; if necessary, repeat at 2 minntes intervals; maximum 10mg (Smg in anaesthesia). Prophylaxis after infarction- 40mg 4 times daily for 2-3 days then 80mg thrice daily, begining 5-21 days after infarction. Migraine prophylaxis- initially 40mg 2-3 times daily; maintenance 80-160mg daily.

QIMP·15 (35)


.:. ADLOCK Tab. Sonear

placenta. So it should not be given in pregnancy

.:. B·CARD·50 Tab. Nipa

Propranolol hydrochloride I Omg, 40mg &

and lactation.

Atenolol 50mg/tablet

Dosage & admin: By mouth:


80mg/tablet. IOmg x 100's pack: 24.00 MRP 40mg x 1 00's pack: 34.00 MRP

Hypertension, 50mg daily (higher doses no longer considered necessay)

.:. G·PROPRANOLOL Tab. Gonoshas.

Angina, l00mg daily in 1 or 2 doses

Propranolol hydrochloride 40mgltablet.

Arrhythmias, 50-100 mg daily

100's pack: 34.00 MRP

By intravenous injection:

.:. INDEVER Tab. ACI Propranolol hydrochloride 10mg & 40mgltablet.

Arrhythmias, 1-5 mg at a rate of Imglmin,

1 0mg x 250's pack: 60.00 MRP

of 10mg.

40mg x 250's pack: 85.00 MRP

By intravenous infusion:

.:. INDEVER SR Cap. ACI

repeated at 5-minute intervals to a maximum

Arrhythmias, 150mcg/kg over 20 minutes,

Propranolol hydrochloride 40mg & 80mglcapsule

repeated every 12 hours if required.

(sustained release)

Early intervention within 12 hours of

40mg x l OO's pack: 92.00 MRP

infarction, 5·10mg by slow i.v injection, then

80mg x l OO's pack: 1 54.00 MRP

by mouth 50mg after 15 minutes, 50mg after

.:. PROPRANOL Tab. Opsonin Propranolol hydrochloride 10mg, 40mg/tablet.

12 hours, then 100mg daily.

IOmg x 200's pack: 42.00 MRP

with intravenous injection of atropine sulphate

40mg x 1 OO's pack: 3 1 .00 MRP

Note: Excessive bradycardia can be countered 0.6-2.4mg in divided doses of 0.6mg.

Drug inter: The effects of other myocardial

ATENOLOV 1,42,48,52 ATENOLOL: Tablet/Injection Atenolol, chemically a phenylacetamide, and functionally a selective � I·blocker.

Mode of action: Atenolol as a beta-blocker, it has an effect on the heart by blocking the action of noradrenaline and adrenaline on �-receptor and controls its rate and rhythm of beating. By reducing the heart rate and the force of muscle contraction, atenolol reduces the need of heart muscle for oxygen (demanad). Because angina occurs when oxygen demand of the heart exceeds supply, atenolol is also helpful in treating angina.

depressant agents, including anti·arrhythmics such as quinidine, procainamide, or lignocaine, phenytoin, and medicines which interfere with calcium transport, such as verapamil, may be enhanced by atenolol. The effects of atenolol are diminished by beta·adrenoceptor stimulating agents such as isoprenaline; the hypotensive effects of atenolol may be dangerously reversed and the peripheral vasoconstrictor effects enhaced by alpha-adrenoceptor stimulating agents such as noradrenaline or those with mixed alpha·and beta-adrenoceptor stimulating properties such as adrenaline; bradycardia may also occur. The effects of atenolol may be enhanced by adrenergic neuron blocking agents

Ind: Hypertension, angina, arrhythmias.

such as guanethidine or bethanidine, or

CII: Atenolol is contraindicated with a known

catecholamine·depleting agents such as reserpine

hypersensitivity to atenolol, severe bradycardia,

and the hypotensive effects by diuretics. Atenolol

second or third degree heart block, uncontrolled

may enhance some of the cardiac effects of

heart failure, hypotension, severe peripheral

digitalis and diminish others. It has been

vascular disease (including intermittent

suggested that clonidipe withdrawal symptoms

claudication), sick sinus syndrome, cardiogenic

may be exacerbated in patients who are

shock, phaeocromocytoma (without a

concurrently taking a beta blocker.

concomitant alpha blocker), metabolic acidosis.

(For more detail, see under the text of

SIE: Pronounced fatigue and cold extremities

propranolol).

have been observed in 1 0-20% of the treated subjects. Complaints about bradycardia, dizziness

.:. ANETOL Tab. Ambee

and gastrointestinal symptoms are less frequent.


Despite its relative selectivity, atenolol can cause

50mg x 1 00'8: 77.00 MRP

bronchospasms in asthma patients. Rarely observed side-effects are sleep disturbances,

.:. ANOL Tab. Modern Atenolol 50mgltablet

depression, paresthesiae, impotence, exanthema,

50mg x lOO's: 77.00 MRP

psoriasis exacebations and arthropathies. Clinically relevant changes in the blood sugar

.:. ANOL-50 Tab. Medicon Atenolol 50mg/tablet

have hardly occurred. There is no clarity as to

50mg x l OO's: 76.00 MRP

the practical significance of the above mentioned

.:. ATENOL Tab. Pharmadesh

changes in the lipid metabolism.


Precautions: Poor cardiac reserve. Avoid in

50mg x l OO's: 80.00 MRP

overt heart failure, anaesthesia and chronic

.:. ATEZEN Tab. Zenith Atenolol 50mg & 100mg/tablet ' 50mg x 100 s: 77.00 MRP

obstructive airway disease or asthma. Withdrawal of beta·blocking drugs should be gradual in

.:. BETANOL Tab. Sanofi·aventis Atenolol 25mg, 50mg & 1 00mgltablet 25mg x l OO's: 45.00 MRP 50mg x 100's: 77.00 MRP 100mg x 100's: 1 38.00 MRP

.:. BETASEC Tab. Opsonin Atenolol 50mgltablet 100's pack: 76.00 MRP

.:. BPNOL Tab. Delta Atenolol 50mg/tablet 50mg x l OO's: 76.06 MRP

.:. CARDILOCK Tab. Aleo Pharma Atenolol 50mg/tablet 50mg x loo's: 77.00 MRP

.:. CARDIPRO Tab. Square Atenolol 50mg & 1 00mg/tablet 50mg x l OO's: 77.00 MRP 100mg x lOO's: 143.00 MRP

.:. CARDISEF Tab. Supreme Atenolol 50mg & 100mg/tablet 50mg x l oo's: 77.00 MRP 100mg x l OO's: 1 36.00 MRP

.:. CARSEC Tab. Medimet Atenolol 50mg & 1 00mgltablet 50mg x 140's: 1 06.40 MRP 100mg x 140's: 184.80 MRP

.:. ENOL Tab. Edruc Atenolol 50mgltablet. 1 00's pack: 77.00 MRP

.:. ETNOL Tab. Bio·pharma Atenolol 50mg & 1 00mg/tablet 50mg x l OO's pack: 77.00 MRP 100mg x 100's pack: 137.00 MRP

.:. LONET 50 Tab. Beximco Atenolol 50mgltablet. 100's pack: 77.00 MRP

.:. LOPRES Tab. Orion Atenolol 50mg/tablet. 1 00's pack: 70.00 MRP

.:. NORMATEN Tab. Navana Atenolol 50mg/tablet. 100's pack: 76.00 MRP

.:. NORPRESS Tab. Chemico Atenolol 50mg & 100mgltablet. 50mg x 100's pack: 75.00 MRP 100mg x 60's pack: 75.00 MRP

.:. PRECINOL Tab. Doctor's Atenolol 50mg/tablet 1 00's pack: 73.00 MRP

.:. RECARD Tab. Rephco Atenolol 50mg & l oomgltablet. 50mg x 100's pack: 75.00 MRP

.:. T ENOCARD Tab. Aristopharma Atenolol 50mgltablet 100's pack: 75.00 MRP

.:. TENOL Tab. Sonear Atenolol 50mgltablet 50mg x 1 00's pack: 75.00 MRP

.:. T ENOLOC Tab. Acme Atenolol 50mg & 100mg/tablet. 50mg x 100's: 77.00 MRP

patients with ischaemic heart disease. Withdrawal

100mg x lOO's: 136.00 MRP

of clonidine. Co· administration with verapamil or class I antidysrhythmic agents modifies the

.:. ATIN Tab. Jayson Atenolol 50mgltablet

tachycardia of hypoglycaemia. If symptoms

l OO's pack: 76.00 MRP

Atenolol 25mg. 50mg & 1 00mgltablet.

attributable to slow heart rate reduce dose. In

.:. ATOL Tab. Mystic

25mg x 50's: 22.50 MRP

renal disese reduce dose.


50mg x 250's: 192.50 MRP

Pregnancy & lactation: Atenolol crosses the

100's pack: 75.00 MRP

1 00mg x 100's: 1 38 .00 MRP

1 00mg x l OO's: 136.00 MRP ,

.:. T ENOREN Tab. ACI

QIMP·15 (36)


BISOPROLOV 37

BISOPROLOL FUMARATE: Tablet Bisoprolol fumarate is a cardio·selective I · adrenoceptor blocker.

Mode of action: See under the text of propranolol.

Ind: Hypertension, angina pectoris & stable chronic moderate to severe heart failure (in addition to ACE inhibitors &diuretics).

CII: Untreated cardiac failure, cardiogenic shock, sinoatrial block, second or third degree AV block, marked bradycardia (heart rate less than 60 beat per minute) or extreme hypotension.

SIE: Bisoprolol is well tolerated. Those reported are due to its pharmacological actions· lassitude, dizziness, mild headache, perspiration, aggravation of intermittent claudication or Raynaud's disease & paresthesia observed. Sleep disturbances only rarely reported.

Precaution: Use with care in patients with prolonged PR interval, poor cardiac reserve & peripheral circulatory disturbances, such as· Raynaud's phenomenon, chronic obstructive airways disease and diabetes. In patients with ischaemic heart disease, treatment should not be withdrawn abruptly.

Pregnancy & lactation: Like other ·blockers, use only if essential. Safety in humans not established.

Dosage: Hypertension & angina: Usually Smg once daily; recommended range Smg·l0mg daily. Chronic heart failure: The treatment should be started with a small dose; the dose should be slowly & progressively up-titrated according to tolerance up to the maximum recommended dose of 10mg (if needed, please see detailed prescribing information in the text), In patients with final stage renal or liver disease, dose should not exceed to 10mg bisoprolol once daily, No dose adjustment required for the elderly. Child: Not recommended for children. Drug inter: May potentiate the effects of other cardiovascular agents, insulin or other oral

association class [] or III) chronic congestive

concomitantly without any adverse effects.

heart failure. In the treatment of heart failure,

fncreased monitoring of digoxin is recommended

carvedilol is usually given in conjunction with

when initiating, adjusting, or discontinuing the

diuretics, digitalis and ACE inhibitors. It may be

dose of carvedilol. Rifampin· pretreatment with

used in patients unable to tolerate an ACE

rifampin resulted in a 60% decrease in Cmax and

inhibitor. Carvedilol may also be used in patients who are not receiving digitalis, hydralazine or nitrate therapy.

CII: Carvedilol is contraindicated in patients with NYHA class IV (New York HeaI1 Association class IV) decompensated cardiac failure requiring intravenous inotropic therapy; bronchial asthma or related bronchospastic conditions; second or third·degree AV block, sick sinus syndrome (unless a permanent pacemaker is placed); cardiogenic shock or severe bradycardia. Therapy is not to be initiated in severe heart failure.

SIE: Postural hypotension, dizziness, headache, fatigue, gastrointestinal disturbances, bradycardia; occasionally diminished peripheral circulation, peripheral oedema and painful extremities, dry mouth, dry eyes, eye irritation or disturbed vision, impotence, disturbances of micturition, influenzae·like symptoms, rarely angina, AV block, exacerbation of intermittent claudication or Raynaud's phenomenon, allergic skin reactions, exacerbation of psoriasis, nasal stuffiness, wheezing, depressed mood, sleep disturbances, paresthesia, heart failure, changes in liver enzymes, thrombocytopenia, leukopenia are also reported.

Cautions: Take caution in hepatic impairment, and in heart failure, monitor clinical status for 2· 3 hours after initiation and after increasing each dose. Before increasing dose ensure that the renal function and heart failure are not deteriorating.

Pregnancy & lactation: Carvedilol should not be used during pregnancy & breast· feeding, since no studies have been performed in pregnant

& lactating women; animal studies have shown that carvedilol crosses the placental barrier & also excreted in breast milk. Safety and efficacy of carvedilol in neonates & children have not been established.

AVe. Clonidine· b-receptor antagonists potentiate the pressor reaction which may follow sudden withdrawal of treatment with clonidine although, in theory, the a·blocking action of carvedilol should modify the pressure rise.

.:. ARILOL Tab, Pacific

Carvedilol 6.25mg 1 2.Smg &2Smg/tablet 6.25111g x 30's pack: 90.00 MRP 1 2.5mg x 30's pack: I SO.OO MRP 25111g x 30's pack: 240.00 MRP

.:. CARDIVAS Tab. Sun Pharma

Carvedilol 6.2Smg & 12.Smg/tablet

6.25111g x SO's pack: 225.00 MRP 1 2.Smg x 30's pack: 1 9 5 .00 MRP

.:. CARVETAB Tab. Medimet

Carvedilol 6.2Smg & 1 2 .Smg/tablet 6.25mg x 50's pack: l SO.OO MRP I 2 . Smg x SO's pack: 2S0.00 MRP

.:. CARVIDA Tab. Delta

Carvedilol 6.2Smg & 1 2.Smg/tablet 6.2S111g x 30's pack: 89.99 MRP 1 2.5mg x 30's pack: I SO.02 MRP

.:. CARVISTA Tab. Incepta

Carvedilol 6.2Smg, 1 2.Smg & 2Smg/tablet 6.2Smg x 100's pack: 300.00 MRP 1 2 .Smg x 50's pack: 2S0.00 MRP 2Smg x 30's pack: 240.00 MRP

.:. CAVELON Tab. Drug Inter.

Carvedilol 6.25mg & 1 2.Smg/tablet 6.2Smg x 50's pack: I SO.OO MRP 1 2.5mg x SO's pack: 300.00 MRP

.:. CARVIPRESS Tab. Acme Carvedilol 6.2Smg & 1 2 .Smg/tablet 6.25mg x 30's pack: 90.00 MRP

1 2.50mg x 30's pack: I SO.OO MRP

.:. COREL Tab. Rephco

Carvedilol 6.25mg & 1 2.Smg/tablet 6.25mg x 30's pack: 75.00 TP 1 2.5mg x 30's pack: 120.00 TP

.:. DILAPRESS Tab. Beximco

thus lower peripheral resitance. It also has

Dosage & admin: In hypertension- treatment shonld be started with 12.Smg once daily, then increased to 2Smg daily after 2 days; the dose may further be increased to max. SOmg daily in single or divided doses, at intervals of at least 2 weeks, if necessary. In elderly patients, the initial dose of 12.Smg daily may be sufficient for adequate control. In angina- initially 12.Smg twice daily, then increased to 2Smg twice daily after 2 days. In heart failure- carvedilol may be given initially 3.12Smg twice daily with food; dose may be increased at intervals of at least 2 weeks to 6,2Smg twice daily, then to 12.Smg twice daily, then to 2Smg twice daily. The dose may be increased to highest dose tolerated, in patients less than 8Skg body-weight, max. 2Smg twice daily and in patients over 8Skg, max. SOmg twice daily.

Carvedilol 6.2Smg & 1 2.Smg/tablet

antiproliferative properties and is a scavenger of

Drug inter: Digoxin· in normal healthy

6.2Smg x SO's pack: 1 5 0.00 MRP

reactive free oxidant radicals. It is used in the

volunteers a single dose of carvedilol taken

1 2.5mg x SO's pack: 2S0.00 MRP

treatment of hypertension, angina pectoris and

together with a single dose of digoxin resulted in

.:. DJOLA Tab. SandozINovartis

hypoglycemic drugs. Rifampicin can reduce the half·life of bisoprolol.

.:. BISLOL Tab. Opsonin

Bisoprolol hemifumarate 2.Smg & Smg/tablet 2.Smg x 30's pack: 1 80.00 MRP Smg x 30's pack: 300.00 MRP

.:. CONCOR Tab. Popular

Bisoprolol hemifumarate 2.Smg & Smgltablet

2.Smg x 30's pack: 369.00 MRP Smg x 30's pack: 492.30 MRP

CARVEDILOV1.26

CARVEDILOL: Tablet It is a nonselective b·adrenergic receptor blocker, having an additional peripheral arteriolar vasodilator action by diverse mechanisms, and

congestive heart failure.

significantly increased levels of digoxin 24·hour

Ind: Treatment of hypertension, angina pectoris

later. Patients with congestive heart failure

and mild or moderate (NYHA- New York Heart

stabilized on digoxin have been given carvedilol

Carvedilol 6.25mg, 1 2 .Smg & 25mg/tablet 6.2Smg x 30's pack: 90.00 TP 1 2.S0mg x 30's pack: I SO.OO TP 2Smg x 30's pack: 240.00 TP

.:. DILATREND Tah. Roche

Carvedilol 6.2Smg, 1 2 .5mg &2Smg/tablet 6.2Smg x 30's pack: 270.00 MRP 25mg x 30's pack: 660.00 MRP

.:. DILGARD Tab, General

Carvedilol 6.2Smg, I 2.Smg & 2Smg/tablet

6.2Smg x 30's pack: 90.00 MRP 1 2 .Smg x 30's pack: l S 0 .00 MRP 2Smg x 30's pack: 240.00 MRP

.:. DILOL Tab. Mystic

Carvedilol 6.2Smg & 1 2.Smg/tablet 6.2Smg x 1 00's pack: 300.00 MRP 1 2 .Smg x SO's pack: 2S0.00 MRP

.:. DILOCARD Tab. White Horse

Carvedilol 6.2Smg, 1 2 .Smg & 2Smg/tablet

6.25mg x' 30's pack: 1 20.00 MRP 1 2 .Smg x 30's pack: 2 1 0.00 MRP

QIMP-15 (37)

.:. DUROL Tab. Square CarvediloI 6.25mg, 1 2.5mg & 25mg/tablet 6.25mg x 30's pack: 90.00 MRP 1 2.50mg X 30's pack: 150.00 MRP 25mg x 30's pack: 2 10.00 MRP

.:. EXEPRESS Tab_ Opsonin Carvedilol 6.25mg, 1 2.5mg & 25mg/tablet 6.25mg x 50's pack: 1 50.00 MRP 12.5mg x 30's pack: 150.00 MRP 25mg x 20's pack: 1 60.00 MRP

.:. KARVEDIL Tab_ ACI Carvedilol 6.25mg, 1 2 .5mg & 25mg/tablet 6.25mg x 50's pack: 150.00 MRP 1 2.Smg x 30's pack: 120.00 lP 25mg x 30's pack: 240.00 MRP

:. KOREG Tab. Silva

•

Carvedilol 6.25mg, 1 2 .5mg & 2Smgltablet 6.25mg x 30's pack: 90.00 MRP 12.5mg x 30's pack: 1 50.00 MRP 25mg x 30's pack: 240.00 MRP

:. UCARDOL Tab. UniHealth

•

Carvedilol 6.25mg, 1 2.5mg & 25mg/tablet 6.2Smg x 30's pack: 90.00 MRP 12.Smg x 30's pack: ISO.OO MRP 25mg x 30's pack: 270.00 MRP

.:. VESODIL Tab. Rangs Pharma Carvedilol 6.25mg, 12.5mg & 25mg/tablet 6.25mg x 30's pack: 90.00 MRP 1 2.5mg x 30's pack: 1 50.00 MRP 25mg x 30's pack: 240.00 MRP

CELIPROLOL65 CELIPROLOL HCI: Tablet Celiprolol is a beta,-selective beta adrenoreceptor blocking agent. It is available as celiprolol hydrochloride BP 200mg & 400mg tablet. Mode of action: Celiprolol is a beta,-selective (cardioselective), beta-adrenoreceptor blocking agent, which possesses mild beta2 agonist activity and weak alpha2-blocking activity, but does not exhibit quinidine-like membrane stabilizing properties. These and other receptor modulating effects may account for its absence of cardiodepressant effect, lack of adverse effects on serum lipids, decrease in peripheral vascular resistance as well as a reduced risk of adverse bronchopulmonary effects compared with other beta-adrenoreceptor blocking agents. Ind: Celiprolol is indicated for the treatment of hypertension and effort-induced angina pectoris. CII: All beta blockers are contraindicated in bronchial asthma or other obstructive lung disorders, uncontrolled heart failure, cardiogenic shock, sick-sinus syndrome, grade 2 and 3 A-V block, intranodal A-V block and severe bradycardia and also avoid in severe renal impairment. SIE: Adverse effects are transient and mild. The most frequently observed are headache, dizziness, fatigue, abdominal discomfort, weakness, rash, bradycardia, oedema, palpitation and muscle cramps; depression and pneumonitis reported rarely. Precautions: Avoid abrupt withdrawal specially in angina; first-degree AV block; reduce oral dose of celiprolol in liver disease; renal impairment: diabetes; history of obstructive airways disease. Celiprolol therapy must be reported to the

anaesthetist prior to general anaesthesia. Pregnancy & lactation: Celiprolol in not teratogenic in experimental animals but is embryotoxic in rabbits and rats at 54 to 60 times the highest recommended human oral dose. It crosses the placenta in animals but is not known to what extent it crosses the placenta in humans. So, it should not be given in pregnancy unless its use is considered to be essential. The extent to which celiprolol is excreted in breast milk has not been established therefore, breast-feeding should not be continued by mothers receiving this product.

Dosage & admin: Hypertension: The recommended initial dose is 200mg once daily. The effect will be fully established after one to two weeks. The dose may be increased to 400mg once daily if necessary at 2 to 4 week intervals. Angina pectoris: It is indicated for the long term management of patients with angina pectoris. The usual dose is 200mg once daily; dosage may be increased to 400mg or 600mg once daily after 2 to 4 weeks intervals until optimum clinical response obtained. If treatment is to discontinue, reduce the dosage gradually over a period of 1 to 2 weeks. Celiprolol should be taken at least one hour before or two hours after meals. Drug inter: Verapamil and celiprolol both slow A-V conduction and depress myocardial contractility through different mechanisms. Therefore, clinical signs and ECG should be carefully monitored during the treatment with this combination particularly when initiating therapy. The bioavailability of celiprolol has been shown to be reduced by the concomitant administration of chlorthalidone, hydrochlorothiazide or theophylline. While no effect on the efficacy of celiprolol has been demonstrated, patients response should be monitored after dosage adjustments involving these medications.

.:. CELIPRESS Tab. SK+F Celiprolol hydrochloride 200mg & 400mg/tablet 200mg x 20's pack: 160.00 MRP 400mg x lO's pack: 150.00 MRP

LABETALOL48.1 33 LABETALOL: TabletJInjection Labetalol is an adrenergic receptor blocking agent possessing both alpha- I (post-synaptic) and beta-receptor blocking activity. It is available as labetalol hydrochloride USP 100mg & 200mg tablet & 50mg in 10mi ampoule (i.e 5mglml) for intravenous (i. v) injection. Mode of action: Labetalol lowers blood pressure by blocking peripheral arteriolar a-adrenoceptors, thus re d uci n g peripheral resistance, and by concurrent B-.blockade_ protects the heart from retlex sym!,,,,hc!ic drive that would otherwise occur. Cardiac out put is not significantly reduced at r('st or after moderate exercise. Increases in systolic blood pressure during exercise are n..'dUl'cd hut corresponding changes in diastolic prl.'''''UI'L' at\,' L',"'sc n l i a l l y norma l. All these effects \\ ( lu lL! he c \ I1L'clCd to henefit hypertensive p:111L'l1h.


Ind: Labetalol is indicated for hypertension (including hypertension in pregnancy, hypertension with angina, and hypertension following acute myocardial infarction). Parenteral therapy is specially indicated in severe hypertension when rapid control of blood pressure is essential; controlled hypotension in anaesthesia. ell: Labetalol is contraindicated in second or third degree heart block, cardiogenic shock and other conditions associated with severe and prolonged hypotension or severe bradycardia. When peripheral vasoconstriction suggests low cardiac output, the use of injection to control hypertensive episodes following acute myocardial infarction is contraindicated . S/E: Adverse effects reported are postural hypotension (avoid upright position during and for 3 hours after i. v administration). tiredness. weakness, headache, rashes, scalp tingling, difficulty in micturition, epigastric pain. nausea. vomiting, liver damage. Precautions: There have been rare reports of severe hepatocellular injury with labetalol therapy. The hepatic injury is usually reversible and has occurred after both short and long term treatment. Appropriate laboratory testing should be done at the first sign or symptom of liver dysfunction. If there is laboratory evidence of liver injury or the patient is jaundiced, labetalol therapy should be stopped and not re-started. Labetalol does not adversely affect renal function and is particularly suitable for use in hypertensive patients with renal disease. Pregnancy & lactation: Although no teratogenic effects have been demonstrated in animals, labetalol should only be used during the first trimester of pregnancy if the potential benefit outweighs the potential risk. Adverse events of unknown causality have been reported very rarely in breast-fed neonates. Caution should be exercised when labetalol is administered to breast feeding women.

Dosage & admin: By mouth: The recommended initial dose is 100mg twice daily with food, increased at intervals of 14 days to usual dose of 200mg twice daily, upto 800mg daily in 2 divided doses. Maximum 2.4gm daily in divided doses. The usual maintenance dose is 200 to 400mg twice daily. Optimal doses are usually lower in patients also receiving a diuretic since an additive antihypertensive effect can be expected. By i. v injection: 50mg over at least 1 minute, repeated after 5 minutes if necessary; maximum total dose 200mg. By i. v infusion: 2mgiminute until satisfactory response then discontinue; usual total dose 50200mg. Hypertension of pregnancy: 20mg/hour, doubled every 30 minutes; usual maximum 160mg/hour. Hypertension following myocardial infarction: 15mg/hour, gradually increased to maximum 120mg/hour. Dilution fluid can be used: Lahetalol injection is compatible with 5% dextrose BP, 0.18% sodium chloride and 4% dextrose BP, 0.3% potassium chloride and 5% dextrose BP, compound sodium lactate BP i. v infusion fluids. Overdosage: If needed please consult


manufacturer'S literature.

Drug inter: Labetalol may enhance the hypotensive effects of halothane. Care should be taken if labetalol is used concomitantly with either class I antiarrhythmic agents or calcium antagonists of the verapamil type. The hypotensive effect of labetalol may be reduced when used in combination with prostaglandin synthetase inhibitors (NSAIDs). Dosage adjustments may therefore be necessary.

.:. LABECARD LV Inj_ Popular

Labetalol hydrochloride USP 50mg in I Oml ampoule (i.e 5mglmJ): i.v injection. I Oml (50mg) ampoule x I 's pack: 100.00 MRP .:.

LABETA Tab_ Beximco

Labetalol hydrochloride USP 1 00mg & 200mgltablet. 1 00mg x 60's pack: 360.00 MRP 200mg x 30's pack: 300.00 MRP

METOPROLOU'·33 METOPROLOL: TableUinjection Ind: Hypertension, arrhythmias, angina, migraine prophylaxis, thyrotoxicosis.

CII; SIE; Cautions: See under propranolol hydrochloride; reduce dose in hepatic and renal impairment,

Dosage & admin: By mouth: Hypertension, the usual initial dosage is 25 to lOOmg daily in a single dose, whether used alone or added to a diuretic; maintenance 100200mg daily in 1-2 doses_ Angina, 50-100mg 2-3 times daily_ Arrhythmias, usually 50mg 2-3 times daily; up to 300mg daily in divided doses if necessary Migraine prophylaxis, lOO-200mg daily in divided doses Thyrotoxicosis (adjunct), 50mg 4 times daily_ By intravenous injection: Arrhythmias, up to 5mg at a rate 1- 2mglmin, repeated after 5 minutes if necessary, total dose 10-15mg_ In surgery, 2-4mg by slow i.v injection at induction or to control arrhythmias developing during anaesthesia; 2mg doses may be repeated to a max_ of 10mg_ Note: Excessive bradycardia can be countered with i.v injection of atropine sulphate 0.6-2.4mg in divided doses of 0.6mg.

.:. BETALOC Tab_ Drug Inter_

Metoprolol tartrate 25mg & 50mg/tablet 25mg x 100's pack: 1 50.00 MRP 50mg x 100's pack: 200.00 MRP

.:. BETALOC-XR Tab, Drug Inter_ Metoprolol succinate 47.5mg equivalent to metoprolol tartrate 50mg/tablet & metoprolol succinate 95mg equivalent to metoprolol tartrate 1 00mgltabiet 50mg x l OO's pack: 400.00 MRP 100mg x 50's pack: 250.00 MRP

.:. LOPRESOR Tab_ Bristol Metoprolol tartrate 50mgltablet 1 00's pack: 1 3 1 .00 MRP

.:. METALOC Tab_ Renata

Metoprolol tartrate 50mg & l OOmg/tablet 50mg x 100's pack: 1 3 1 .00 MRP 100mg x 50's pack: 1 25.00 MRP

.:. METOCARD LV Inj_ Popular

QIMP-15 (38)

Metoprolol tartrate Imgflml; 5ml ampoule: i.v injection. 5mg (5ml) amp x I's pack: 600.00 MRP

.:. PRELOC Tab_ Opsonin

Metoprolol tartrate 50mgltablet 50's pack: 65.00 MRP

.:. PRESONIL Tab_ Incepta

Metoprolol tartrate 50mg/tablet 100's pack: 130.00 MRP

.:. SELOMET Tab_ UniHeaIthlUniMed Metoprolol tartrate 50mg/tablet 50mg x 30's pack: 60.00 MRP

.:. SELOMET-SR Tab_ UniHealthlUniMed Metoprolol succinate USP 47.5mg equivalent to metoprolol tartrate USP 50mg/tablet (sustained release).

Dosage & admin: Dosages are same as other normal tablet preparations - see above nnder the text_ 50mg x 30's pack: 1 20.00 MRP

.:. TOPRESS Tab_ SK+F

Metoprolol tartrate 50mgltablet 1 00's pack: 200.00 MRP

NEBIVOLOV2 NEBIVOLOL: Tablet Nebivolol is a competitive and selective ? 1 receptor antagonist with mild vasodilating properties. Nebivolol reduces heart rate & blood pressure at rest & during exercise. It is available as 5mg film coated tablet. Mode of action: See description above. Ind: Nebivolol is indicated in: I . Mild to moderate essential hypertension; 2. Mild to moderate hypertension, with coronary artery diseases (CAD), with hyperlipidemia, in elderly, with diabetes mellitus; 3. Chronic heart failure (CHF). CII: Known hypersensitivity to nebivolol, cardiogenic shock, untreated phaeochromocytoma, sick sinus syndrome, 2nd & 3rd degree heart block, liver insufficiency or liver function impairment, pregnancy and lactation, bradycardia (heart rate < 50/m), metabolic acidosis, bronchial asthma, history of bronchospasm. SIE: The most common side effects are headache, dizziness, tiredness, paraesthesia, diarrhea, constipation, nausea, dyspnoea, and edema. Other side effects include bradycardia, slowed AV conduction!AV block, hypotension, heart failure, intermittent claudication, impaired vision, impotence, depression, nightmares, dyspepsia, flatulence, vomiting, bronchospasm, rash.

Precautions: � ,- receptor antagonist should not be used in ischemic heart disease, circulatory disorders, first degree heart block, anesthesia, diabetes, hyperthyroidism, chronic obstructive pulmonary disorders, and allergen sensitivity. Pregnancy & lactation: Nebivolol is contraindicated in pregnancy and lactation.

Dosage & admin: Hypertension: Adults: 5mg (ltablet) daily, preferable at the same time of the day_ Elderly (patients over 65 years): The recommended starting dose is 2_5mg (half tablet) daily_ The dose may be increased to 5mg (Itablet) daily if needed_ Due to limited

experience in patients above 75 years, caution must be exercised and these patients to be monitored closely_ Patient with renal insufficiency: The recommended starting dose is 2.5mg (half- tablet) daily_ The daily dose may be increased to 5mg (ltablet) if needed_ Nebivolol 5mg if given in combination with l2_5-25mg hydrochlorothiazide, an additional antihypertensive effect has been observed_ Chronic heart failure: The initial uptitration in case of chronic heart failure patients should be done according to the following steps at 1-2 weekly intervals based on patient tolerability: L25mg daily, to be increased to 2_5mg once daily, then to 5mg once daily and then to 10mg once daily_ The maximum recommended dose is 10mg daily_ Children: In children safety and efficacy of nebivolol has not been demonstrated. Overdosage: The symptoms of overdose are bradycardi�, hypotension, bronchospasm and acute cardiac insufficiency. Symptomatic and supportive therapy should be given in overdose_ Drug inter: Nebivolol interacts with calcium channel antagonists (e.g. verapamil. diltiazem ). class I antiarrythrnic drugs and amiodarone. Storage: Store below 25?C.

.:. BIPINOR Tab_ ACI Nebivolool 5rng/tablet (film-coated ) 5mg x 30's pack: 240.00 IP

Alpha adrenoceptor blocking drugs The useful alpha-adrenoceptor blocking drugs include: Prazosin, Doxazosin, Indoramin & Terazosin. Mode of action: Alpha-adrenoceptor blocking drugs have post synaptic alpha-blocking effect, results in vasodilatation. These drugs however, cause a rapid reduction in blood pressure after the fust dose and should be introduced with caution. Alpha-blockers may be used with other antihypertensive drugs in the treatment of hypertension. Note: For furhter infornation, see below under the text of individual products.

PRAZOSIN21,33 .:. ALPHAPRESS Tab, Renata

Prazosin hydrochloride l mg & 2mg/tablet. Ind: Hypertension, congestive cardiac failure. SIE: Postural hypotension, drowsiness, weakness, headache, ve11ig, asthma. Cautions: First dose may cause collapse due to hypotension; reduce initial dose in renal failure.

Dosage & admin: Adult: 0_5 mg on first evening, then 0_5 mg 2 or 3 times daily for 37 days followed by I mg 2 or 3 times daily for 3-7 days; there after, increase gradually as required_ Max_ 20mg daily_ Child: Not recommended. I mg x 1 00's pack: 243.00 MRP 2mg x 100's pack: 450.00 MRP

QIMP.15 (39)


TERAZOSIN21.26,49

ACE Inhibitors2 1.22.23

CAPTOPRIVI,33

TERAZOSIN HCl: Tablet

Angiotensin converting enzyme (ACE) inhibitors

CAPTOPRIL: Tablet. Ind: In mild to moderate hypertension alone or

Terazosin hydrochloride is a selective ·1 adrenoceptor competitive blocking agent with a longer duration of action. It is a quinazoline derivative. When it is taken orally, it is absorbed very rapidly & action started within IS minutes of ingestion.

Mode of action: See above under the text of alpha adrenoceptor blocking drugs.

Ind: Mild to moderate hypertension. In benign prostatic hyperplasia, single therapy is useful to relieve signs and symptoms.

CII: Known to be hypersensitive to terazosin or its analogues.

SIE: Dizziness, lack of energy, peripheral oedema; urinary frequency and priapism reported.

Cautions: First dose may cause collapse due to hypotension (within 30-90 minutes, therefore should be taken on retiring to bed), may also occur with rapid dose increase. Caution should also be observed when terazosin is adrninistered with other antihypertensive agents, avoid the possibility of significant hypotension. When adding terazosin to a diuretic or other antihypertensive agent, dosage reduction and adjustment may be necessary. In case of initiation of terazosin therapy patients should be cautioned to avoid driving & hazardous tasks, where injury could result due to syncope.

Use in pregnancy & lactation: Terazosin is not recommended during pregnancy unless the potential benefit overweighs the potential risk to mother & foetus. As terazosin is excreted in the breast milk, caution should also be exercised when administered in nursing mother.

Dose: Hypertension, initial dose- lmg at bedtime (compliance with bedtime dose important, see cautions); dose can be increased or doubled after 7 days if necessary; usual maintenance dose- 2·10mg once daily; more than 20mg daily rarely improves efficacy. Benign prostatic hyperplasia, initial dose lmg at bedtime is starting dose of all patients and this dose should not be exceeded; subsequent dose- the dose slowly increases to achieve the desired response, the usual recommended dose range is 5-10mg once daily. .:. PROSTOL Tab. Drug Inter. Terazosin hydrochloride Img & 2mg/tablet. Img x SO's pack: ISO.OO MRP 2mg x SO's pack: 250.00 MRP

.:. TERAZON Tab. Incepta Terazosin hydrochloride 2mg & Smg/tablet. 2mg x SO's pack: 250.00 MRP Smg x 30's Pack: 240.00 MRP

include:

Captopril, Cilazapril, Enalapril, Fosinopril, [midapril, Lisinopril, Moexipril, Perindopril, Quinapril, Ramipril & Trandolapril. Mode of action: Angiotensin converting enzyme or ACE inhibitors inhibit the conversion of angiotensin I to angiotension II. They are effective and generally well tolerated.

Indications: Hypertension: ACE inhibitors are usually considered in hypertension when thiazides and betablockers are contra-indicated, not tolerated, or failed to control blood pressure; they are particularly indicated for hypertension in insulin dependent diabetics with nephropathy.

Heartfailure: ACE inhitiotrs have a valuable role in all grades of heart failure, combined when appropriate with diuretic and digoxin treatment.

Myocardial infarction:

ACE inhibotors are used

in the immediate and long term management of patients who have had a myocardial infarction.

Diabetic nephropathy:

It is recommended that

all diabetic patients with nephropathy causing albuminuria and all

insulin·dependent diabetic

patients with established microalbuminuria should be treated with an ACE inhibitor even if the blood pressure is normal .

CII: Hypersensitivity to ACE inhibitors; known or suspected renovascular disease (unless the blood pressure cannot be controlled by other drugs); aortic stenosis; pregnancy; porphyria.

SIE: Hypotension, dizziness, headache, fatigue, asthenia, nausea (or occasionally vomiting), diarrhoea, muscle cramps, persistent dry cough, throat discomfort, voice changes, taste alteration, stomatitis, dyspepsia, abdominal pain, renal impariment, hyperkalaemia, angioedema, urticaria, rashes and hypersensitivity reactions; blood disorders (e.g agranulocytosis, neutropenia); other side-effects reported include upper respiratory symptoms, hyponatraemia, tachycardia, palpitations, arrhythmias, myocardial infarction and CVD, back pain, flushing, jaundice, pancreatitis, sleep disturbances, nervousness, mood changes, paraesthesia, impotence, alopecia.

Cautions: Renal function and electrolytes and monitored during treatment. Caution with diuretics as the first dose may cause hypotension, because ACE inhibitors can cause rapid fall of blood pressure in volume depleted patients, therefore if possible, any diuretic should be discontinued or the dose reduced significantly 23 days before initiation of an ACE inhibitor. Diuretic therapy may be resumed if necessary after a few weeks. autoimniune collagen disorders & during concurrent use of immunosuppressant or leukopenic drugs monitor WBC counts & urinary protein before & during therapy. Lactation.

I . Angiotensin.converting enzyme (ACE) inhibitors 2. Angiotensin·II receptor antagonists or blocker

& digitalis in severe refractory congestive cardiac failure; following myocardial infarction; diabetic nephropathy in insulin-dependent diabetes.

CII; SIE; Caution: See above under the text of ACE inhibitor.

Dosage & admin: Mild to moderate hypertension. initially 12.5mg twice daily with a thiazide diuretic. Maintenance, 25mg twice daily increasing gradually at 2·4 weeks interval if necessary to maximum 50mg twice daily. Severe hypertension. 25 mg twice daily increasing if necessary to SOmg three times daily. Heart failure· as adjunct initially 6.25-12.Smg under close medical supervision; usual maintenance dose 25mg 2-3 times daily, and maximum 150mg daily. Diabetic nephropathy- 75-100mg daily in divided doses; if further blood pressure reduction required, other antihypertensives may be used in conjuction with captopril; in severe renal impairment, initially 12.5mg twice daily. .:. ACETOR Tab. Drug Inter. Captopril 2Smgltablet. 100's pack: 300.00 MRP

.:. ANGITEN Tab. Ibn Sina Captopril 2Smgltablet. 100's pack: 304.00 IP

.:. CAPOTRIL Tab. Aleo Pharma Captopril 25mgltablet. 40's pack: 1 20.00 MRP

.:. CATOPIL Tab. Zenith Captopril USP 1 2.5mg & 2Smg/tablet. 12.Smg x 100's pack: 17S.00 MRP 2Smg x 100's pack: 300.00 MRP

.:. CARDOPRIL Tab. Beximco Captopril 2Smg & 50mg/tablet. 2Smg x 100's pack: 300.00 IP SOmg x lOO's pack: 600.00 IP

.:. TOPRIL Tab. Jayson Captopril 2Smg/tablet. SO's pack: 1 39.S0 IP

should be checked before starting ACE inhibitors

Patients with renal impairment, S.L.E & other

Drugs affecting the renin angiotensin system

with thiazide diuretics; severe hypertension resistant to other treatment; adjunct to diuretics

Anaesthesia.

Dosage: See under the text of the individual preparation.

ENALAPRIVI .33 ENALAPRIL MALEATE: Tablet Ind: All grades of hypertension; treatment of congestive heart failure as adjunct; prevention of symptomatic heart failure and prevention of coronary ischaemic events in patients with left ventricular dysfunction.


Dosage & admin: Hypertension, used alone, initially 5mg once daily; if used in addition to diuretic, in elderly patients or in renal impairment, initially 2.5mg daily; usual maintenace dose IO·20mg once daily; in severe hypertension may be increased to max. 40mg once daily.


Heart failure· in asymptomatic left ventricular dysfunction, as an adjunct, initially 2.Smg daily under close medical supervision; usual maintenance 20mg daily in 1·2 divided doses. .:. ANAPRIL Tab. SK+F

Enalapril maleate Smg & I Omg/tablet.

Smg x 100's: lS2.00 MRP IOmg x 100's: 27S.00 MRP

.:. ENARIL Tab. Beximco

Enalapril maleate Smgltablet.

QIMP·15 (40)

concurrently, reduce the dose or discontinue the diuretic for 2·3 days beforehand and resume later if required. Child: Not recommended. Drug inter: K+ sparing diuretics, K+ supplements and indomethacin (should be

.:. PENDORIL Tab. Renata

Perindopril erbuntine 2mg, 4mg &8mg/tablet. 2mg x lO's pack: 70.00 MRP 4mg x lO's pack: 1 20.00 MRP 8mg x lO's pack: 240.00 MRP

.:. PERIPRIL Tab. Incepta

avoided).

Perindopril erbumine 2mg, 4mg &8mg/tablet.

.:. ACEPRIL Tab. Drug Inter.

4mg x 20's pack: 240.00 MRP

Lisinopril 5mg & I Omgltablet Smg x 50's: 200.00 MRP

2mg x 20's pack: 1 40.00 MRP Smg x 20's pack: 480.00 MRP

Smg x 100's: 1 00.00 IP

IOmg x 30's: 202.50 MRP

.:. ERIL Tab. Orion

.:. FASTRIL Tab. Gaco

RAMIPRIU6

Smg x SO's: SO.OO MRP

5mg x 50's: 139. 1 3 MRP

RAMIPRIL: Tablet

IOmg x SO's: 100.00 MRP

IOmg x 30's: 1 5 1 .39 MRP

.:. MINIPRIL Tab. Renata

.:. G·LISINOPRIL Tab. Gonoshasthaya

Smg x 100's: 1 52.00 MRP

Smg x SO's: 1 00.00 MRP

IOmg x 1 00's: 202.00 MRP

.:. LINORIL Tab. Rephco

Enalapril maleate Smg & IOmg/tablet.

Enalapril maleate Smg & I Omg/tablet.

Lisinopril Smg & I Omg/tablet

Lisinopril 5mgltablet

.:. VASOPRIL Tab. Square

Lisinopril 5mg/tablet

Enalapril maleate Smg & IOmg/tablet.

Smg x 50's: 1 29.50 IP

5mg x 100's: 1 2 5.00 MRP

.:. LIPRIL Tab. Acme

10mg x 50's: 1 12.50 MRP

FOSINOPRIU 1.51 .:. MONOPRIL Tab. Squibb/Kapricorn

Fosinopril sodium I Omg/tablet

Ind: Hypertension; congestive heart failure (adjunct)


Dosage & admin: Hypertention, initially lOmg daily, increased if necessary after 4 weeks; usual dose range lO·40mg (doses over 40mg not shown to increase efficacy); the first dose should preferably be given at bedtime. If ACE inhibitor used in addition to diuretic, caution should be taken (see notes above under caution under ACE inhibitor). Heart failure (adjunct), initially lOmg daily under close medical supervision (in hospital in severe heart failure; intiation in hospital is also recommended for patients with mild to moderate heart failure); if initial dose is well tolerated, may be increased to up to 40mg once daily. 20's pack: 400.00 MRP

LISINOPRIU 1.52 LISINOPRIL: Tablet Ind: All grades of essential hypertension and renovascular hypertension where standard therapy ineffective or inappropriate. Congestive heart failure in conjunction with diuretics andlor digitalis.

CII: Pregnancy, aortic stenosis, cor pulmonale. SIE: Hypotension, renal failure, angioedema, rash, dizziness, headache, diarrhoea, cough, fatigue, palpitations, chest pain, asthenia.

Cautions: Renal impairment; monitor renal function before &during treatment; Lactation.

Dosage & admin: Adults: Initially, 2.Smg once daily increasing gradually over 2·4 weeks to maintenance of 10·20mg once daily. Therapy to be initiated in hospital only. In hypertension, if any diuretic is given

Lisinopril 5mg & I Omg/tablet 5mg x 50's: 150.00 MRP IOmg x 30's: 165.00 MRP

.:. LISPRIL Tab. Medimet


5mg x 50's: 1 12.50 MRP

.:. NEOPRIL Tab. Beximco


5mg x 1 00's: 300.00 IP

:. NOP Tab. Ambee

•

Lisinopril l Omg/tablet 5mg x 50's: 1 7 7 . 00 MRP

.:. STRIL Tab. ACI

Lisinopril Smgltablet 5mg x 28's: 84.00 MRP

PERINDOPRIUI .53 PERINDOPRIL ERBUMINE: Tablet. Perindopril erbuntine is an angiotensin· converting enzyme (ACE) inhibitor. It is available as 2mg, 4mg &8mg tablet.

Ind: Essential hypertension; congestive heart failure (as adjunct).

CII; Caution: See above under the text of ACE inhibitor.

SIE: See notes above under the text of ACE inhibitor; asthenia, flushing, mood &sleep disturbances.

Dosage & Admin: Hypertension· 4mg once a day in the morning, if necessary, the dose may be increased to 8mg after 1 month of treatment; it should be taken before food. Congestive heart failure· perindopril should be started under close medical supervision at a starting dose of 2mg in the morning, this may be increased to 4mg once blood pressure acceptability has been demonstrated. Elderly patients, start treatment with 2mg daily. .:. CADNYL 4 Tab. Square

Perindopril erbumine INN 4mgltablet. 4mg x 30's pack: 360.00 MRP

.:. COVERSYL Tab. Servier

Perindopril erbumine 4mg &8mg/tablet. 4mg x lO's pack: 1 65.00 MRP 8mg x 30's pack: 750.00 MRP

Ramipril is an angiotensin converting enzyme (ACE) inhibitor, which after hydrolysis to ramiprilat, blocks the conversion of angiotensin I to the vasocons-trictor substance, angiotensin II. So, inhibition of ACE by ramipril results in decreased plasma angiotensin II, which leads to decreased vasopressor activity and decreased aldosterone secretion. Thus, ramipril exerts its antihypertensive activity. It is long acting and well tolerated; so, can be used in long term therapy.

Ind: i. Mild to severe hypertension, where it may be used alone or in combination with thiazide diuretics. ii. Congestive heart failure. iii. To reduce the risk of stroke, myocardial infarction and death from cardiovascular events in patients with a history of cardiovascular disease. iv. Proteinuric non·diabetic nephropathy.


Dosage & admin: Dosage of Ramipril must be adjusted according to the patient tolerance and response. Hypertension. For the management of hypertension in adults not receiving a diuretic, the usual initial dose is 1.2S·2.Smg once daily. Dosage generally is adjusted no more rapidly than at 2·week intervals. The usual maintenance dosage in adults is 2.S·20mg daily given as a single dose or in 2 divided doses daily. If BP is not controlled with Ramipril alone, a diuretic may be added. Congestive heart failure after myocardial infarction· In this case, Ramipril therapy may be initiated as early as 2 days after myocardial infarction. An initial dose of 2.5mg twice daily is recommended, but if hypotension occurs, dose should be reduced to 1.2Smg twice daily. Therapy is then adjusted to a target daily dose of Smg twice daily. Prevention of major cardiovascular events· In this case, the recommended dose is 2.Smg twice daily for the first week of therapy and Smg once daily for the following 3 weeks; dosage then may be increased, as tolerated to a maintenance dosage of lOmg once daily. Dosage in renal impairment· For the patients with hypertension and renal impairment, the recommended initial dose is 1.2Smg once daily. Subsequent dosage should be adjusted according to individual tolerance and BP response, up to a maximum of Smg daily. For the patients with heart failure and renal impairment, the recommended dose is 1.2Smg once daily. The dose may be increased to 1.2Smg twice daily and up to a maximum dose

QIMP-15 (41)

of 2_5mg twice daily depending upon clinical response and tolerability_

Smg x SO's: 400.00 MRP

Overdosage: Limited data on human overdosage

.:. RAMPRIL Tab, Rangs Pharma

l Omg x 30's: 360.00 MRP

are available. The most likely clinical

to hypotension. Because the hypotensive effect of

continued once the blood pressure has stablised.

Smg x 30's: 1 80.00 MRP

Dosage: See below under individual preparation,

effective hypovolemia, it is reasonable to treat

Ramipril BP l.2Smg, 2.Smg &Smg/capsule

solution.

2.Smg x 30's: IS0.00 MRP

1 .2Smg x 30's: 7S .00 MRP

Rarnipril overdosage by infusion of normal saline

Smg x 30's: 240.00 MRP

Drug inter: Concomitant administration with

.:. R-PIL Tab, Bio-pharma

diuretics may lead to serious hypotension and in

Ramipril BP 1 .2Smg, 2.5mg &Smglcapsule

addition dangerous hyperkalemia with potassium .

1 .2Smg x 30's: 90.00 MRP

sparing diuretics. Concomitant therapy with

2.5mg x 30's: ISO.OO MRP

lithium may increase the serum lithium

Smg x 30's: 240.00 MRP

concentration: Reduction in BP may affect the

.:. TRITACE Tab, Sanofi-aventis

ability to drive and operate machinery and this

Rarnipril BP 2.Smg, Smg & l Omgltablet

may be exacerbated by alcohol. NSAIDs may

2.5mg x 28's: 240.80 MRP

reduce the antihypertensive effect of Ramipril

Smg x 28's: 3S2.80 MRP

and cause deterioration of renal function.

l Omg x 28's: 504.00 MRP

CANDESARTAN42 CANDESARTAN: Tablet Candesartan cilexetil is a newer angiotensin-II receptor blocker. It is rapidly and completely bioactivated by ester hydrolysis during

absorption from the gastrointestinal tract to candesartan, a selective ATI subtype angiotensin II receptor antagonist.

Mode of action: See above under the text of 'angiotensin-II receptor blocker'.

Ind: It is indicated for the treatment of

hypertension. It may be used alone or in combination with other antihypertensive agents.

CII: Pregnancy. Known hypersensitivity to any

.:. PIRAMIL Tab_ SandozINovartis Ramipril BP 2.Smg &Smg/tablet

Angiotensin-II receptor blocker (ARB)21 .26.54

2.Smg x 28's: 168.0.0 IP Smg x 28's: 252.00 IP

.:. PRICARD Tab, White Horse Ramipril BP 2.Smg/tablet

Introduction: The angiotensin-II receptor

2.Smg x SO's: 200.00 MRP

blockers are newer antihypertensive drugs, act by

.:. PRIMACE Cap, Beximco

blocking the action of angiotensin-II on the heart,

Ramipril BP 1 .2Smg, 2.Smg &Smg/capsule

peripheral vasculature and kidney. They are also

1 .2Smg x 30's: 7S.00 IP

useful in the management of heart failure.

2.Smg x 30's: I S0.00 IP

The angiotensin-II receptor blockers that known

Smg x 30's: 240.00 IP

to us till this day are- Losartan, Valsartan &very

.:. PROTACE Tab, UniHealth

recently introduced are- Candesartan,

Ramipril BP 1 .2Smg, 2.5mg &5mg/tablet

Eprosartan, Irbesartan and Telmisartan

1 .2Smg x 30's: 90.00 MRP

Mode of action: Angiotensin-II is a potent

2.Smg x 30's: I SO.OO MRP

5mg x 30's: 240.00 MRP

blockers block the vasoconstrictor and

they do not cause persistent dry cough as

Ramipril BP 2.Smg &5mgltablet

happens with ACE inhibitors.

Smg x SO's: 3S0.00 MRP

renal arterial stenosis.

Ind: Hypertension; congestive heart-failure &

2.Smg x SO's: ISO.OO MRP

CII: Hypersensitivity to any of the components

.:. RAMIL Tab, Popular

of angiotensin-II receptor blocking preparations,

Ramipril BP 2.Smg &Smgltablet

e.g losartan, valsartan etc. Contra-indicated in

2.Smg x 30's: I S O.OO IP

pregnancy &lactation, if pregnancy is detected

Smg x 30's: 240.00 IP

during therapy should be discontinued as soon as

.:. RAMIPRESS Tab, Silva

possible.

Ramipril BP 1 .2Smg, 2.Smg &Smg/capsule 1.2Smg x 30's: 7S.00 MRP

SIE: The side-effects that experienced with

Smg x 30's: 240.00 MRP

specific side-effects see below under individual

angiotensin-II blockers are mild and rare. For

2.Smg x 30's: ISO.OO MRP

.:. RAMIPRO Tab, General

preparation.

2.Smg x SO's: ISO.OO MRP

and/or volume-depleted patients, such as, those

.:. RAMORIL Tab, Incepta

hypotension may occur in rare cases after

Precautions & warnings: Sodium-depleted

Ramipril BP 2.5mg &5mg/tablet

receiving high doses of diuretics, symptomatic

Smg x 30's: ISO.OO MRP

initiation of therapy. Sodium and/or volume

Ramipril BP 1 .2Smg, 2.Smg, Smg &

depletion should be corrected before starting

10mg/capsule

treatment with angiotensin- Jl receptor blockers _

detected candesartan should be discontinued as soon as possible.

in rat milk. Therefore, a decision should be made

breakdown of bradykinin and other kinins, thus

.:. RAMICARD Tab, Drug Inter,

text of 'angiotensin-II receptor blocker' .

II. They have many properties &effects similar

over ACE inhibitors that they do not inhibit the

Smg x 30's: 240.00 MRP

somnolence.

Skin & appendages: Rash, sweating increased. Urinary system: Hematuria.

It is not known whether candesartan is excreted

to those of the ACE inhibitors; but their merit

1 .2Smg x SO's: 12S.00 MRP

2.Smg x 30's: I SO.OO MRP

Psychiatric disorders: Anxiety, depression,

aldosterone secreting effects of angiotensin-II by selectively blocking the binding of angiotensin

.:. RAMACE Cap, Opsonin

Ramipril BP 1 .2Smg, 2.5mg &5mg/capsule

Musculoskeletal system: Myalgia.

Plateletlbleeding-clotting disorders: Epistaxis.

Pregnancy & lactation: When pregnancy is

hypertension. The angiotensin-II receptor

Smg x 30's: 240.00 MRP

increased, hyperglycaemia, hypertriglyceridemia,

hyperuricemia.

component in the pathophysiology of

1.2Smg x 30's: 7S.00 MRP 2.Smg x 30's: 138.00 MRP

SIE: Body as a whole: Asthenia, fever. Central & peripheral nervous system: Paresthesia, vertigo. Gastrointestinal system: Dyspepsia, gastroenteritis. Cardiovascular system: Tachycardia, palpitation. Metabolic & nutritional: Creatine phosphokinase

Precautions &Warmings: See above under the

of the renin-angiotensin system and an important

Ramipril BP 1 .2Smg, 2.Smg &Smg/tablet

component of this product.

vasoconstrictor, the primary vasoactive hormone

:. RACARD Tab, Pacific

•

1 .2Smg x SO's: 12S.00 MRP

in the supine position and, if necessary, given an

i.v infusion of normal saline. Treatment can be

.:. RIPRIL Tab, Square

Rarnipril is achieved through vasodilation and

2.Smg x SO's: 2S0.00 MRP

hypotension occurs, the patient should be placed

Ramipril BP 2.Smg &Smg/tablet

2.Smg x 30's: 1 20.00 MRP

manifestations would be symptoms attributable


for example, by reducing the diuretic dose. If

in human milk, but has been shown to be present whether to discontinue nursing or discontinue the drug, taking into account the importance of the

drug to the mother.

_

Dosage & admin: Dosage must be individualized. Blood pressure response is dose related over the range of 2mg to 32mg, The usual recommended starting dose is 16mg once daily when it is used as monotherapy in patients who are not volume depleted, Candesartan can be administered once or twice daily with total daily dosage ranging from Smg to 32mg, Larger doses do not appear to have a greater effect, and there is relatively little experience with such doses, Most of the antihypertensive effect is present within 2 weeks, and maximal blood pressure reduction is generally obtained within 4 to 6 weeks of treatment with candesartan, No initial dosage adjustment is necessary for elderly patients, for patients with mildly impaired renal function, or for patients with mildly impaired hepatic function, For patients with possible depletion of intravascular volume (e.g patients treated with diuretics, particularly those with impaired renal

QIMP-lS (42)


function), candesartan should be initiated

General: Uncommon- weakness, hyperhydrosis,

calcium channel blocking agent) may be

under close medical supervision and

malaise, weight gain. Rare- cold sensation,

added.

consideration should be given to

wannth sensation, pain.

Patients with intravascular volume depletion:

administration of a lower dose_ Candesartan

Haematopoielic: Rare- anaemia.

Volume andlor sodium-depletion should be

may be administered with or without food_ If

Musculoskeletal/connective tissue: Uncommon

corrected before initiating therapy with

blood pressure is not controlled by

muscle cramp, swelling extremity. Rare- arthritis,

irbesartan or a lower starting dose (e.g 7Smg)

candesartan alone, a diuretic can be added_

muscleache, myalgia, extremity weakness,

should be considered. Patients undergoing

Candesartan may be administered with other

stiffness of lower extremity.

haemodialysis should receive a starting dose

antihyper-tensive agents.

Nervous systeJll: Uncommon- orthostatic

of 7Smg, and the dose should be adjusted

Paediatric patients: Safety and effectiveness in

dizziness, numbness, sleep disturbance,

according to B.P response. If the blood

pediatric patients have not been established.

depression, emotion labile/disturbance,

pressure is not adequately controlled, the dose

Drug inter: No significant interactions have

somnolence, vertigo, paresthesia. Rare- stress

can be increased.

been reported with other drugs such as glyburide.

related disorder, tremor coordination disturbance,

Paediatric use: Safety and effectiveness in

nifedipine, digoxin, warfarin,

disturbing dreams.

paediatric patients have not been established.

hydrochlorothiazide and oral contraceptives in

Elderly and patients with renal or hepatic

healthy volunteers.

Renal/Genitourinary: Uncommon- urination abnormality. Respiratory: Uncommon- epistaxis,

impairment: No dosage reductions is generally

Because candesartan is not metabolised by the

dyspnea. Special senses: Uncommon- vision

necessary in the elderly or in patients with

cytochrome P 450 system and has no effect on P

disturbance, hearing abnormality. Rare- eye

impaired hepatic function (mild to moderate

450 enzymes, interactions with drugs that inhibit,

disturbance, eyelid abnormality, visual field

degree) or impaired renal function (regardless

or are metabolised by, those enzymes could not

abnormality, medication bad taste, taste

of degree), unless accompanied by uncorrected

be expected.

disturbance.

volume depletion.

Others: As with other angiotensin-II receptor

Irbesartan is contra-indicated in those

.:. ARB

8 Tab. Square

Candesartan cilexetil INN Smgltablet

antagonists, rare cases of hypersensitivity

patients who are hypersensitive to irbesrtan.

reactions (urticaria, angioedema) have been

Drug inter: No interactions would be expected

Smg x 30's pack: I SO.OO MRP

reported since the marketing of irbesartan. The

.:. CANDESA Tab. General

following have been reported very rarely during

dependent upon cytochrome P450 isoenzymes.

post-marketing surveillance: arthralgia, asthenia,

Irbesartan is primarily metabolized by CYP2C9,

hyperkalemia, myalgia, tinnitus jaundice,

however, during clinical studies, no significant

elevated liver function tests and impaired renal

drug interactions were observed when irbesartan

function including isolated cases of renal failure

was co-administered with warfarin (a drug

Candesartan cilexetil INN 4mg, Smg & l 6mg/tablet 4mg x 30's pack: 1 05.00 MRP Smg x 30's pack: l SO.OO MRP l 6mg x 30's pack: 330.00 MRP :. GIRAN Tab. Aristopharma

.

Candesartan cilexetil INN Smg & l 6 mgltablet Smg x 30's pack: I SO.OO MRP 16mg x 30's pack: 330.00 MRP

"to occur with drugs whose metabolism is

in patients at risk.

metabolized by CYP2C9). Irbesartan does not

CII; Precautions & Warnings: See above under

affect the pharmacokinetics of digoxin. The

the text. The safety of irbesartan in the presence

pharmacokinetics of irbesartan is not affected by

of heart failure has not been fully defined.

co-administration with nifedipine or

Sudden death has occurred in some studies of

hydrochlorothiazide. Based on experience with

.:. VESOTAN Tab. Rangs Pharma

patients with heart failure, and although such

the use of other drugs that affect the renin

Candesartan cilexetil INN Smg & 1 6mg/tablet

deaths may have reflected the natural history of

Bmg x 30's pack: I SO.OO MRP

angiotensin system, concomitant use of

the underlying heart failure, caution is

potassium sparing diuretics, potassium

recommended when treating such patients with

supplements, or salt substitutes containing

16mg x 30's pack: 330.00 MRP

IRBESARTAN63 IRBESARTAN: Tablet lrbesartan is an angiotensin-II receptor

irbesartan. At this time, experience is limited

potassium may lead to increase in serum

with irbesartan in the treatment of patients with

potassium. Reversible increases in lithium

ventricular dysfunction or cardiac arrythmias;

concentra-tions have been very rarely reported with irbesartan. Therefore, if co-administration of

caution is advised. Pregnancy

& lactation: Drugs that act directly

antagonist, introduced very recently for the

on the renin-angiotensin system can cause fetal

treatment of hypertension. It is available as

and neonatal morbidity and death when

irbesartan INN 75mg, 1 50mg & 300mgltablet.

administered to pregnant women. lrbesartan is

Mode of action: See above under the text of

excreted in the milk of lactating rats, but not

'angiotensin-II receptor blocker'.

known whether irbesartan or its metabolites are

Ind: lrbesartan is indicated for the treatment of

excreted in human milk. So, a decision should

hypertension.

be made whether to discontinue breast-feeding or

SIE: Adverse events in patients receiving

to discontinue the drug, taking into account the

irbesartan are generally mild and transient with

importance of irbesartan in the therapy of the

irbesartan and lithium proves necessary, careful monitoring of serum lithium is necessary. .:. CAVAPRO Tab. UniHeaIth Irbesartan INN 75mg, 150mg & 3OOmgltablet. 75mg x 30's pack: I BO.OO MRP 1 50mg x 30's pack: 360.00 MRP 300mg x l O's pack: 240.00 MRP

.:. IRBES Tab. SK+F

Irbesartan INN 75mg & 150mg/tablet. 75mg x 50's pack: 250.00 MRP

no relationship to dose:

mother and the potential risk to the infant.

Cardiovascular: Uncommon- subjective rhythm

Dosage

disturbance, flushing, ECG abnormality, cardiac

either alone or in combination with other

murmur, cardiac rhythm disturbance, orthostatic

antihypertensive agents (e.g thiazide diuretic,

hypotension, atrial rhythm disturbance,

beta-adrenergic blocking agent, long-acting

bradycardia, hypotension. Rare- syncope,

calcium-channel blocking agent). The usual

conduction disorder, myocardial infarction.

initial and maintenance dose of irbesartan is

It is an angiotensin-II receptor (type ATl )

Dermatologic:

lS0mg once daily. It may be administered

antagonist, & now regarded a s the first-line

erythema. Rare- dermatitis, acne, scalp-hair

with or without food. Therapy should be

therapy option for treating high blood pressure.

abnormality.

adjusted according to blood pressure


EndocrinelMetaboliclElectrolyte imbalance:

response. Patients requiring further reduction

'angiotensin-II receptor blocker'.

Uncommon- sexual dysfunction, libido change.

in blood pressure, dose may be increased to

Ind: All grades of hypertension, congestive

Rare- breast disorder, gout, hot flashes.

300mg once daily.

heart-failure & renal arterial stenosis. It may be

Gastrointestinal: Uncommon- constipation,

adequately controlled with irbesartan alone, a

used alone or in combination with other

flatulance, dry mouth, abdomen distention. Rare

diuretic (e.g hydrochlorothiazide 12.Smg

antihypertensive agents. It is an effective

abnormal stool, decreased or increased appetite,

daily) or another antihypertensive drug (e.g

alternative for patients who have to discontinue

oral lesion, dysphagia, oesophagitis.

beta-adrenergic blocking agent, long-acting

an ACE inhibitor because of persistent dry

Uncommon- pruritus, facial

& admin: Irbesartan may be used

If blood pressure is not

1 50mg x 30's pack: 270.00 MRP

LOSARTAN POTASSIUM21,26 LOSARTAN POTASSIUM: Tablet

QIMP-lS (43)


cough.

100mg x 30's pack: 300.00 MRP

Losartan potassium INN SOmgltablet.

SIE: The side-effects that experienced with

.:. LK Tab. Pacific

SOmg x 30's pack: 1 20.00 MRP

losartan are usually mild and occasional.

Losartan potassium INN 2Smg & SOmgltablet.

.:. LOSTAN Tab. Ziska

Symptomatic hypotension may occur,

2Smg x 30's pack: I OS.00 MRP


particularly in patients with intravascular volume


SOmg x 30's pack: I SO.OO MRP

depletion (e.g those treating with diureics).

.:. LOK-50 Tab. Globe

.:. LOTAS Tab. Ambee

Hyperkalaemia may occur occasionally. Other

Losartan potassium INN SOmg/tablet.

Losartan potassium INN SOmg/tablet. SOmg x 30's pack: 1 70.00 MRP

side-effects may include- diarrhoea, dizziness,

SOmg x 30's pack: i so.oO MRP

myalgia, migraine, urticaria, pruritus, taste

.:. LOPO Tab. Bio-pharma

.:. OSARTAN Tab. Aristopharma

disturbance, upper respiratory infection, leg pain



& altered liver function tests.

2Smg x 30's pack: IOS .00 MRP

2Smg x SO's pack: 1 7 S.00 MRP

& Precautions: See above under the text. Dosage & Admin: The usual slarting dose is



.:. LOPOS Tab. Zenith

.:. OSARTEK Tab. Pharmadesh

50mg once daily; but, in patients with possible



CII

depletion of intravascular volume (e.g patients

2Smg x 30's pack: lOS :00 MRP

2Smg x SO's pack: I SO.OO MRP

treated with diuretics), patients with a history

2Smg x l OO's pack: 3S0:00 MRP

SOmg x 30's pack: 1 6S.00 MRP

of hepatic or renal impairment

& in case of

very elderly patients (over 75 years) should be

SOmg x 30's pack: 1 80:00 MRP

.:. OSARTIL Tab. Incepla

SOmg x 1 00's pack: 600:00 MRP

Losartan potassium INN 2Smg, SOmg &

slarted with 25mg once daily. It can be

.:. LOSA-25 Tab. Alco Pharma

1 00mg/tablet.

administered once or twice daily with tOlal

Losartan potassium

2Smg x SO's pack: 17S .00 MRP

INN 2Smgltablet.

SOmg x SO's pack: 300.00 MRP

daily doses ranging from 2Smg to increasing

2Smg x 30's pack: IOS.00 MRP

upto lOOmg after several weeks, if necessary.

.:. LOSA-SO Tab. Alco Pharma

1 00mg x 30's pack: 300.00 MRP

If blood pressure is not controlled by 10sarIan


.:. OSTAN Tab. Renala

alone, a diuretic may be added at a low dose.

SOmg x 30's pack: I S I .SO MRP


Losartan may be administered with ·or without food. Children- not recommended. Drug inter: Losartan potassium, as with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics (e.g spironolactone, triamterene, amiloride), potassium supplements, or salt substitutes containing potassium may lead to increases in serum potassium. Besides, no significant drug interactions have been identified by clinical trials with hydrochlorothiazide, digoxin, warfarin, cimetidine, ketoconazole and phenobarbital.

.:. LOSACARD Tab. Novo Healthcare Losartan potassium USP 2Smg & SOmg/tablet. 25mg x 30's pack: IOS.00 MRP SOmg x 30's pack: ISO.OO MRP .:. LOSACOR Tab. Healthcare Losartan potassium INN SOmgltablet. SOmg x 30's pack: 19S.00 MRP .:. LOSAN Tab. Orion Losartan potassium INN 2Smg & SOmg/tablet. 2Smg x 30's pack: I OS.00 MRP SOmg x 30's pack: 1 80.00 MRP .:. LOSANIL Tab. Medicon Losartan potassium INN SOmgltablet. SOmg x 30's pack: 1 65.00

MRP

.:. ANGILOCK Tab. Square

.:. LOSAP Tab. Doctor's



l OOmgltablet.

SOmg x 30's pack: ISO.OO MRP

2Smg x SO's pack: 17S.00 MRP

.:. LOSAR Tab. Nipa



1 00mg x 30's pack: 300.00 MRP

SOmg x 30's pack: 16S.00 MRP .:. LOSARCAR Tab. Mediniet

.:. ANREB Tab. General Losartan potassium

INN

2Smg & SOmgltablet.

2Smg x SO's pack: 1 7 S.00 MRP

Losartan potassium INN 2Smg & SOmgltablet. 2Smg x SO's pack: 1 7 S.00 MRP



:. ARATEN Tab. UniHealth

.:. LOSARDIL Tab. Dtug Inter.




2Smg x SO's pack: 17S.00 MRP

•



.:. CARDON Tab. SK+F

.:. LOSART Tab. Acme



lOOmgltablet.


2Smg x 30's pack: IOS.00 MRP SOmg x 30's pack: 1 82 . 1 0 MRP .:. PARTEN Tab. Jayson Losartan potassium INN 2Smg & SOmgltablet. 2Smg x 30's pack: 90.00 IP SOmg x 30's pack: l S0.00 IP .:. PROSAN Tab. Beximco Losartan potassium INN 2Smg & SOmgltablet. 2Smg x SO's pack: 17S.00 IP SOmg x SO's pack: 300.00 IP .:. REPACE Tab. Sun Pharma Losartan potassium INN 2Smg & SOmg/tablet. 2Smg

�

SO's pack: 17S.00 MRP

SOmg x SO's pack: 300.00 MRP .:. ROSATAN Tab. ACI Losartan potassium INN 2Smg & SOmg/tablet. 2Smg x 30's pack: IOS.00 IP SOmg x 30's pack: 1 80.00 IP .:. SARLO Tab. Rephco Losartan potassium INN SOmg/tablet. SOmg x 30's pack: 1 20.00 MRP .:. TARAN Tab. Chemico Losartan potassium INN 2Smg & SOmgltablet. 2Smg x SO's pack: 17S.00 MRP SOmg x SO's pack: 300.00 MRP .:. XELOTAN Tab. Pharmasia Losartan potassium INN SOmgltablet. SOmg x 30's pack: 1 80.00 IP

OLMESARTAN52



SOmg x 40's pack: 240.00 MRP

.:. LOSATAN Tab. Popular

Olmesartan medoxomil is a selective angiotensin

1 00mg x 20's pack: 200.00 MRP


II receptor (subtype ATl ) antagonist. It is

OLMESARTAN MEDOXOMIL: Tablet

.:. COZARIL Tab. Hallmark

lOOmgltablet.

available as olmesartan medoxomil INN 20mg &



40mg tablet.

2Smg x 30's pack: 7S .00 MRP


Mode of action: Olmesartan medoximil blocks


1 00mg x 30's pack: 300.00 MRP

the vasoconstrictor effects of angiotenSin II by

.:. E-TAN Tab. Edruc

.:. LOSIUM Tab. Ibn Sina

selectively blocking the binding of angiotensin II



to the AT I receptor in vascular smooth muscle.

SOmg x 30's pack: I SO.OO IP


Its action is, therefore, independent of the

: LARB Tab. Opsonin


pathways for angiotensin II synthesis .


.:. LOSPIL Tab. White Horse

Ind: Olmesartan is indicated for the treatment of

100mgltablet.

Losartan potassium USP SOmgltablet.

hypertension. It may be used alone or in



combination with other antihypertensive agents.


.:. LOSPRE Tab. Kumudini

CII: Hypersensitivity to any of its ingredients.

•.

QIMP-15 (44)


SIE: In general, the side-effects are mild & in a

TELMISARTAN: Tablet

machinery.

small number undesired events have been reported, such as- dizziness, vertigo, hypotension (rare), tachycardia, abdominal pain, diarrhea, dyspepsia, gastroenteritis, nausea, bronchitis, cough (rare), pharyngitis, rhinitis, rash, angio oedema (rare), arthritis (arthralgia), back pain, myalgia, haematuria, urinary tract infection, hyperlipidemia, hyperuricaemia, hyperkalaemia (rare), chest pain, fatigue, influenza-like symptoms and peripheral oedema. Precautions: Angiotensin II receptor antagonist (olmeartan medoximil) should be used with caution in patients with impaired renal function and renal artery stenosis; patients with aortic or mitral valve stenosis and obstructive hypertrophic cardiomyopathy. The use of olmesartan is not recommended in patients with hepatic impairment, since there is limited experience in this patient group.

Telmisartan is a nonpeptide angiotensin II receptor (type AT I ) antagonist. It is available as telmisartan INN 40mg/tablet (film-coated). Mode of action: See above under the text of 'angiotensin-II receptor blocker'. Ind: Telmisartan is indicated for the treatment of hypertension and heart failure. CIl: Telmisartan is contraindicated in patients who are hypersensitive to any component of the durg. SIE: Dyspepsia, myalgia, abdominal pain. headache and fatigue. Precaution: Impaired hepatic function: As the majority of the drug is eliminated by biliary excretion, caution should be taken for these patients. Renal impairment: Caution should be taken for the patients with renal impairment. Pregnancy & lactation: Telmisartan should not be given in pregnancy and lactation.

Pregnancy & lactation: Valsartan should not be

Pregnancy & lactation: There is no experience with the use of olmesartan medoxomil in pregnant women. But, drugs that act directly on the renin-angiotensin system administered during the second and third trimesters of pregnancy have been reported to cause foetal and neonatal injury and even death to the fetus. So it is probably best to avoid using the drug when pregnancy is detected. Olmesartan is excreted in the milk of lactating rats but it is not known whether olmesartan is excreted in human milk. However, mothers must not breast-feed if they are taking olmesartan medoxomil.

Dosage

Dosage

& admin: Dosage must be

individualized_ The usual initial dose is 10mg

& admin: The usual starting dose of

telmisartan is 40mg once daily_ The dose may be increased up to 80mg if required_ Telmisartan tablet can be administered with or without food_ Children: Safety and effectiveness in pediatric patients has not been established.

may be increased to 20mg once daily as the optimal dose. For patients requiring further reduction in blood pressure after 2 weeks of therapy, the dose of olmesartan may be increased to 40mg_ Doses above 40mg do not appear to have greater effect.

Elderly & renal impairment: The maximum dose in elderly and patients with mild to moderate renal impairment is 20mg once daily_

Children & adolescents:

The safety and

efficacy have not been established in children and adolescents up to 18 years of age_ Drug inter: No significant drug interactions

were reported when olmesartan was co administered with digoxin or warfarin. The blood pressure lowering effect of olmesartan can be increased by concomitant use of other antihypertensive medications. Use of potassium sparing diuretics, potassium supplements, and salt substitutes containing potassium or other drugs that may increase serum potassium levels (e.g heparin) may lead to increases in serum potassium, such concomitant use is therefore not recommended. .:. ABETIS Tab_ ACI

Olmesartan medoxomil INN 20mg & 40mgltablet (film-coated). 20mg x 30's pack: 240.00 MRP 40mg x 30's pack: 450.00 MRP

TELMISARTAN87

Dosage

& Admin: The recommended dose is

80mg once daily, irrespective of race, age, or gender_ In patients whose blood pressure is not adequately controlled, the daily dose may be increased tol60mg, or a diuretic may be added. No dosage adjustment is required for patients with renal impairment or for patients with hepatic insufficiency of nonbiliary origin and without cholestasis. Valsartan may also be administered with other antihypertensive agents_ Child: The safety and efficacy of valsartan have not been established in children. Drug inter: N o clinically significant interactions were observed when valsartan was coadministered with amlodipine, atenolol, cimetidine. digoxin, frusemide, giyburide, hydrochlorothiazide or indomethacin. .:. AROVAN-80 Cap_ Aristopharma

Valsm1an 80mg/capsule. 80mg x 30's pack: 300.00 MRP

Drug inter: See under the text of candesartan.

.:. CARDIVAL Cap_ Drug Inter_

.:. MITOSAN Tab_ SandozINovartis

Valsartan INN 80mg/capsule. 80mg x 30's pack: 21 0.00 MRP

Telmisartan INN 40mg & 80mgltablet. 40mg x 30's pack: 375 .00 MRP 80mg x 30's pack: 600.00 MRP

VALSARTAN21.54

:. DIOVAN Tab_ Novartis

.

Valsartan 40mg, 80mg & 1 60mg/tablel. 40mg x 28's pack: 952.00 MRP 80mg x 28's pack: 1 1 88.00 MRP 1 60mg x 28's pack: 1 764.00 MRP .:. DISYS Tab_ Healthcare

once daily_ In patients whose blood pressure is not adequately controlled at this dose, the dose

given during pregnancy & lactation; if pregnancy is detected during therapy, should be discontinued as soon as possible.

VALSARTAN: CapsulelTablet Ind: Treatment of hypertension. CIl: Hypersensitivity to any of the components of valsartan. Pregnancy & lactation. SIE: The adverse effects that experienced in a few percentage of people are- headache. dizziness, viral infection, upper respiratory tract infection, coughing, diarrhoea, fatigue. rhinitis. sinusitis, back pain', abdominal pain, nausea, pharyngitis, arthralgia. Other adverse experiences with a frequency below 1% included- oedema, asthenia, insomnia, rash, decreased libido & vertigo. There are some changes found during laboratory study, such as, decrease in haemoglobin & haematocrit, neutropenia. Occasional elevations of liver function values. Precautions & warnings: Sodium andlor volume depleted patients, such as, those receiving high doses of diuretics, symptomatic hypotension may occur in rare cases after initiation of therapy. Sodium and/or volume depletion should be corrected before starting treatment with valsartan; (for example, by reducing the diuretic dose). If hypotension occurs, the patient should be placed in the supine position and, if necessary, given an i.v infusion of normal saline. Treatment can be continued once the blood pressure has stablised. Renal artery stenosis: no significant change has been found with short-term administration, yet monitoring is recommended as a safety measure. Effects on ability to drive and use machines: as with other antihypertensive agents, it is advisable to exercise caution when driving or operating

Valsartan 80mg/tablel. 80mg x 30's pack: 255.90 MRP .:. REOVAN Tab_ RAK Pharma

Valsartan 80mg/tablel. 80mg x 30's pack: 300.00 MRP .:. VALPRESS 80 Cap_ Silva

Valsartan INN 80mg/capsule. 80mg x 30's pack: 240.00 MRP .:. VALSAN 80 Cap_ Mystic

Valsartan INN 80mg/capsule. 80mg x 20's pack: 500.00 MRP .:. VALSARTIL Tab. Incepta

Valsartan 40mg. 80mg & 1 60mg/tablel. 40mg x 30's pack: 1 50.00 MRP 80mg x 30's pack: 270.00 MRP 1 60mg x 30's pack: 480.00 MRP

Vasodilator antihypertensive drugs Commonly used vasodilator antihypertensive

Diazoxide, Hydralazille, Milloxidil, Sodium nitroprusside. drugs include-

SODIUM NITROPRUSSIDE 121 .:. SODIUM NITROPRUSSIDE Inj_ DBL/Globex

Sodium nitroprusside dihydrate B.P 50mg/5 ml vial: Injection for i.v infusion. Ind: Immediate reduction of blood prc"urc i n

patients with hypertensive crisis. Concomitant

QIMP-15 (45)


oral antihypertensive medication should be

anaesthetics, inhaled anaesthetics, negative

daily: 2-12 yrs. 37_5-100mg daily. All in two

started while the hypertensive emergency is

inotropics and most other circulatory depressants

divided doses.

being brought under control with sodium

potentiate its hypotensive action.

Drug inter: Hydrochlorothiazide, when

nitroprusside.

The transition from sodium nitroprusside to oral

administered concurrently the following drugs

Producing controlled hypotension during

antihypertensive therapy may predispose to

may interact with thiazide diuretics, such as

anaesthesia in order to reduce bleeding in

severe, sudden hypotension.

alcohol, barbiturates, or narcotics; these may

surgical procedures.

Note: For further information, please consult

cause potentiation of orthostatic hypotension.

Short term therapy of cardiac failure. Patients

manufacturer's literature.

Antidiabetic drugs (oral agents and insulin)

should be commenced on oral therapy as soon as

50mg (5ml) vial: 235.95 MRP

dosage adjustment of the antidiabetic drug may be required.

possible. CII: It should not be used in the treatment of compensatory hypertension. It is also contraindicated in physically poor-risk patients, uncorrected anemia or hypovolemia,

Other antihypertensive drugs-additive effect or

Diuretics L

potentiation. Cholestyramine and colestipol resins- absorption

Thiazides and related diuretics

of hydrochlorothiazide is impaired in the

known inadequate erebral circulation, severe

2_ Loop diuretics

presence of anionic exchange resins.

renal disease or disease states associated with

3_ Potassium sparing diuretics

Corticosteroids, ACTH- intensified electrolyte

vitamin B 12 deficiency and in congenital

4_ Aldosterone antagonists

depletion, particularly hypokalemia.

(Leber's) optic atrophy or tobacco amblyopia.

5_ Osmotic diuretics

Skeletal muscle relaxants, tubocurarine- possible

SIE: Most important side-effects are- excessive

6. Mercurial diuretics

increased responsiveness to the muscle relaxant.

hypotension and cyanide toxicity. Others

7_ Carbonic anhydrase inhibitors_

Lithium- diuretic agents reduce the renal

methemoglobinemia, thiocyanate toxicity,

8_ Diuretics with potassium

clearance of lithium and add a high risk of lithium toxicity.

nausea, retching, diaphoresis, apprehension, headache, restlessness, muscle twitching, retrostemal discomfort, palpitation, dizziness,

Thiazides & related diuretics 21

sparing and thiazide duretics.

drowsiness, paraesthesia warmth, abdominal pain, tachycardia, postural hypotension, bradycardia, electrocardiographic changes, dermatological irritation, rash and flushing, reddening of skin at the injection site and venous streaking, symptoms of hypothyroidism, decreased platelets aggregation and raised intracranial pressure.

Warnings: Only to be used as an infusion with sterile 5% glucose in water. It should not be administered by direct injection. The principal hazards of sodium nitroprusside administration are excessive hypotension and accumulation of cyanide. Precautions: Use with extreme caution in patients whose intracranial pressure is already elevated, with hepatic insufficiency, hypothyroidism, severe renal dysfunction, and patients who are of specially poor surgical risk. Pre-existing anemia nad hypovolemia should be corrected prior to administration. Direct monitoring of blood pressure is mandatory. Patients should remain recumbent during the infusion. When the solution shows coloured reaction, it should be replaced. Pregnancy

& lactation: It is not known if

sodium nitroprusside is harmful to the foetus or infants. Therefore, it should only be given to pregnant or nursing women when the expected benefits outweigh any potential risk. Dosage & admin: Infusion should be started at a very low rate of 3mglkglmin_ with upward titration every few minntes until the desired effect achieved_ The maximum recommended infusion rate is 10mglkglmin_ The reconstituted solution should only be infused by infusion pump, micro-drip regulator_ Care should be taken to avoid extravasation_ Do not admix with other drugs. Overdosage: Overdosage can be manifested as excessive hypotension, cyanide or thiocyanate toxicity_ Drug inter: Ganglion blocking agents and other antihypertensive agents, volatile liquid

NSAID can reduce the diuretic, natriuretic, and antihypertensive effects of loop, potassium

& related diuretics include Bendroj7.umethiazide (Bendroj7.uazide), Benzthiazide, Chlortalidone (Chlorthalidone), Cyciopenthiazide, Hydrochlorothiazide, Clopamide, Hydroj7.umethiazide, Indapamide, Metruside and Polythiazide. Thiazide

But, benzthiazide, clopamide, cyclopenthiazide, and hydrochlorothiazide do

.:. ACUREN Tab. Incepta Hydrochlorothiazide 25mg & 50mgitablet. 25mg x 100's pack: 70.00 MRP 50mg x 100's pack: 100.00 MRP .:. HTZ Tab. UniHealth Hydrochlorothiazide 25mgltablet. 25mg x 100's pack: 70.00 MRP

not offer any significant advantage over bendroflumethiazide or chlortalidone_ Some newer thiazide related diuretics are available, found more potent and effective than the olders, which include-

Indapamide,

Thiazide related diuretics21 CHLORTHALIDONE 1 33

MetoUlzone, Xipamide. CHLORTHALIDONE: Tablet

Thiazides group of drugs2/33 HYDROCHLOROTHIAZIDE

Chlorthalidone is a thiazide related diuretic. Chemically it is a monosulfamyl diuretic which differs from thiazide group in that a double-ring system is incorporated in its structure. Chlorthalidone is a long acting diuretic with low

HYDROCHLOROTHIAZIDE: Tablet.

toxicity. Its diuretic effect occurs in

Hydrochlorothiazide is a thiazide diuretic. It is

approximately 2.6 hours and continues for up to

available as hydrochlorothiazide B P 25mg &

48-72 hours. It is available as chlorthalidone USP

50mgltablet.

25mg tablet.

Mode of action: Thiazides affect the renal

Ind: I . Essential hypertension- as a single drug

tubular mechanisms of electrolyte reabsorption,

or in combination with other antihypertensive

directly increasing excretion of sodium and

drugs. 2. Ascites due to cirrhosis in stable

chloride in approximately equivalent amounts.

patients. 3. Edema due to nephrotic syndrome. 4.

Indirectly, the diuretic action of

Mild to moderate chronic heart failure.

hydrochlorothiazide reduces plasma volume, with

CII: Patients with anuria, diabetes mellitus, gout

consequent increases in plasma renin activity,

and/or hyperuricemia, hyperlipidemia and known

increases in aldosterone secretion, increases in

hypersensitivity to chlorthalidone or other

urinary potassium loss, and decreases in serum

sulfonamide drugs.

potassium.

SIE: Dry mouth, thirst, nausea, vomiting,

Ind: Oedema, hypertension.

storrnach pain, loss of appetite, diarrhea,

CII: Anuria, lactation, severe renal failure.

constipation, feeling weak, drowsy, restless,

SIE: Rashes, thrombocytopenia.

dizziness, headache, or light-headed, fast or

Cautions: May cause hypokalemia; aggravates

uneven heartheat, orthostatic hypotension,

diabetes and gout; renal and hepatic impairment

muscle pain or weakness, low fever, urinating

Dosage

& admin: Adult: Diuresis, 50-100mg

less than usual or not at all, easy bruising or

once or twice daily or intermittently.

bleeding, red or purple spots on skin, purpura,

Hypertension, initially 50-100mg daily as a

dark urine, clay-colored stools, unusual

single or divided doses, max_ 200mg daily_

weakness, numbness or tingly feeling,

Child: Under 6 months upto 3.5mglkg body

photosensitivity, rash urticaria.

wt. daily: 6 months to 2 yrs. 12.5-37.5mg

Precautions:

Renal impairment: Chlorthalidone

QIMP-15 (46)

CARDIOVASCULAR SYSTEM dosage should be reduced in moderate renal

advice. In case of missing dose do not take a

Mode of action: Frusemide inhibits the

failure - every 24 or 48 hours - and should not be

double dose on the following day.

Na+ /K+12CI- co-transport in the ascending limb

Liver disease: There is a risk of precipitating

between several drugs. and in particular lithium

electrolytes (Na+. K+ and CI- ions) and water.

cirrhosis and ascites.

consult physician before taking any other

used in advanced renal failure.

hepatic encephalopathy in patients with liver

Pregnancy

& lactation: It is better to avoid

chlorthalidone in pregnancy as it crosses the

placenta. Significant amount of chlorthalidone

enter breast milk; like other long-acting thiazides. it can suppress lactation. Chlorthalidone should

not be prescribed for lactating mother. Dosage

& admin: Hypertension: Therapy, in

most patients, should be initiated with 25mg single daily dose. If the response is insufficient after a suitable trial, the dosage may be increased to a single daily dose of 50mg. If additional control is required, the dosage of chlorthalidone may be increased to l00mg once daily.

Edema: Adults, initially 50 to

l00mg daily, or

l00mg on alternate days. Some patients may require 150 to 200mg at these intervals or up to 200mg daily. Dosages above this level, however, do not usually produce a greater response. In the elderly, this is a suitable drug for treating hypertension, in particular systolic hypertension. Dose of 50mg daily, or less, should be used to avoid hypovolemia and hypokalemia.

Drug inter: Chlorthalidone may add to or

potentiate tlie action of other antihypertensive drugs. Potentiation occurs with ganglionic

peripheral adrenergic blocking drugs.

Drug inter: To avoid possible interactions

and certain drugs used for cardiac arrhythmia. medication.

.:. HYPEN SR Tab. Opsonin

Indapamide 1.5mg/tablet (sustained release). 20's pack: 150.00 MRP

:. IDATIX Tab. Incepta

•

fndapamide 2.5mgltablet. 50's pack: 25 0.00 MRP

:. IDATIX SR Tab. Incepta

•

lndapamide 1.5mgltablet (sustained release). 5 0's pack: 25 0.00 MRP

.:. INDAPA Tab. Drug Inter.

fndapamide 1.5mgltablet (sustained release). 50's pack: 250.00 MRP

.:. IPIDE-SR Tab. Renata

lndapamide 1.5mg/tablet (sustained release). 30's pack: 15 0.00 MRP

.:. MICTUREX Tab. Orion

lndapamide 1.5mg/tablet (sustained release). 30's pack: 15 0.00 MRP

.:. NATRILIX Tab. Servier lndapamide 2.5mgltablet. 30's pack: 264.00 MRP

.:. NATRILIX SR Tab. Servier

Indapamide 1.5mgltablet (sustained release). lO's pack: 88.00 MRP

.:. NATRI-SR Tab. Renata

Indapamide 1.5mgltablet (sustained release). 30's pack: 15 0.00 MRP

.:. REPRES SR Tab. Square

.:. THALIDON Tab. Popular

lndapamide 1.5 mgltablet (sustained release).


.:. TRILIX SR Tab. Silva

Chlorthalidone USP 25mgltablet.

INDAPAMIDE21.53

30's pack: 15 0.00 MRP

Indapamide 1.5mgltablet (sustained release). 20's pack: 100.00 MRP

Loop diuretics 21.26,105

chemically related to chlorthalidone.

There are four diuretic agents. which are playin g .

Ind: Treatment of essential hypertension.

CII: This drug must not be taken in the following

situations- known allergy to this drug or to sulphonamides; renal failure; serious liver . disease; hypokalaemia.

SIE: Feeling of tiredness (fatigue). Allergic

manifestations. rare cases of skin rash. Feelings

of vertigo when changing f rom lying to standing

position. Increased risk of dehydration in the elderly and heart failure patients.

Variations in certain blood parameters may occur. in particular excessive loss of potassium,

particularly in the elderly or malnourished individuals.

Warnings: Administration of this drug must be stopped in case of liver disease.

Precautions: Use indapamide cautiously in the

following situations- disturbed water/electrolyte balance. diabetes. gout. kidney disease.

Pregnancy

& lactation: In case of pregnancy.

their major role o n the ascending limb o f the

loop of Henle. known as loop diuretics. These

are- Bumetanide. Frusemide. Torasemide &

Ethacrynic acid

Loop diuretics are the most effective drugs & are more useful in emergency manegment of acute edematous conditions, such as acute

pulmonary edema.

Mode of action: Loop diuretics act on the lumen of thick ascending limb of loop of Henle. inhibit the Na+/K+/CI- cotransport & thus decreasing

reabsorption of Na+. K+. and CI-. This leads to

physician before taking indapamide.

daily in single dose, preferably in the morning. Duration of treatment as per physician's

hypertension.

CII: Precomatose state associated with liver cirrhosis.

SIE: Rashes; tinnitus and deafn ess in impaired renal function .

Cautions: Causes hypokalaemia &

hyponatraemia; aggravates diabetes and gout.

liver failure. prostatism . Dosage

& admin: Adult: By mouth, initially

20-80mg once or twice daily, then adjusted according to response. Maximum upto 2gm daily in oliguria. By i.m or slow i.v injection, 2O-40mg; by i.v infusion, in oliguria 0.25-1gm at a rate not exceeding 4mglmin. .:. FRUSIN Tab. Opsonin

Frusemide 40mg/tablet

1 00's pack: 50.00 MRP

.:. FRUSIN Syp. Opsonin

Frusemide 20mg/5ml: syrup 60ml bot: 85.00 MRP

.:. FRUSIN Inj. Opsonin

Frusemide 20mg12ml ampoule: inj ection 25's pack: 82.50 MRP .:. FRUSIX Tab. Gaco

Frusemide 40mgltablet. 100's pack: 50.46 MRP

.:. FRUSIX Inj. Gaco

Frusemide 20mglampoule: injection I ampOUle: 2.73 MRP .:. FURAMID Tab_ Elixir Frusemide 40mg/tablet. 100's pack:

.:. FUSID Tab. Square

Frusemide 40mgltablet.

remove excess water from the body. It does not

.:. FUSID Inj. Square

Frusemide 20mglampoule: injection 10 amps pack: 35.20 MRP

.:. G-FRUSEMIDE Tab. Gonoshas.

Frusemide 40mgltablet

l00's pack: 5 1.00 MRP

.:. G-FRUSEMIDE Inj. Gonoshas.

Frusemide 20mgl2rn1 ampoule: injection 25 amps pack: 68.25 MRP .:. TROFURIT Tab. Ambee Frusemide 40mg/tablet

100's pack: 5 3.00 MRP

.:. TROFURIT Inj. Ambee

Frusemide 20mg/2ml ampOUle: injection 10 amps pack: 35.30 MRP

significantly alter glomerular fi ltration rate. renal

TORASEMIDE26

also increase the Ca++ content of urine. while

TORASEMIDE: Tablet

plasma flow. or acid-base balance. Loop diuretics thiazide diuretics decrease.

FRUSEMIDE21.26,46

Torasemide is also a loop diuretic of sulfonamide group.

Mode of action: See above under the loop diuretics.

Ind: Management of edmea of cardiac. renal and

breast-feeding or desiring pregnancy consult

Dosage: 2.5mg tablet (or 1.5mg SR tablet)

Ind: Oedema of cardiac. hepatic or renal origin. Toxaemia of pregnancy. Mild or moderate

100's pack: 5 3.00 MRP

INDAPAMIDE: Tablet

Indapamide is a thiazide related diuretic.

of loop of henle and blocks the reabsorption of

FRUSEMIDE: Tablet/SyruplInjection. Frusemide is a short-acting loop diuretic of

sulfonamide group. It is available as oral tablet &

syrup and parenteral i.m or i.v injection.

hepatic origin. Management of hypertension. as a sole therapeutic agent or in combination with

other classes of antihyperten sive agents.

CII: Known hypersensitivity to torasemide and

QIMP-15 (47)

other sulfonyl ureas. It is also contraindicated in patients with anuria.

SIE: Usually torasemide is well tolerated. However, a few side effects like dry mouth, dizziness, tiredness, skin rash, diarrhea, constipation, nausea, vomiting, orthostatic hypotension and muscle cramp may occur. All side effects are usually mild and transient. Precautions: Precautions should be taken while torasemide is advised in patients with diabetes, gout, hypotension and liver failure. Pregnancy

& Lactation: As there are no

adequate and well-controlled studies of torasemide have been carried out in pregnant & nursing mother, & animal reproduction studies are not always predictive of human response, torasemide can only be used during pregnancy if it is clearly needed, & caution should be exercised when administering to a nursing mother. Dosage

& admin: Edema- usual oral dose is

Smg once daily, preferably in the morning. If necessary, the dose can be increased stepwise up to 20mg once daily. The usual maximum dose is 40mg daily. Dosage can be taken without regard to meal. Essential hypertension- an oral low dose of 2.Smg once daily is recommended.

If

necessary, the dose can be increased to Smg once daily. Children: Safety and efficacy of torasemide in children have not been established_ Drug inter: ACE inhibitors- potentiation of hypotension may occur. Aminoglycosides torasemide may increase the ototoxicity of aminoglycosides.

Mode of action: Eplerenone is a selective

For patients with an inadequate blood

mineralocorticoid receptor. Eplerenone binds to

pressure response to 50mg once daily, the

the mineralocorticoid receptor and blocks the

50mg twice daily_ Higher dosages of

angiotensin-aldosterone-system (RAAS).

Eplerenone are not recommended either

Aldosterone synthesis, which occurs primarily in

pressure than lOOmg or because they are

factors, including angiotensin I! and other

associated with an increased risk of

mediators such as adrenocorticotropic hormone

hyperkalemia. Pediatric use: The safety and

and potassium. Aldosterone binds to

effectiveness of eplerenone has not been

mineralocorticoid receptors in both epithelial

established in pediatric patients.

(e.g. kidney) and nonepithelial (e.g. heart, blood

vessels, and brain) tissues and increases blood pressure through induction of sodium reabsorption and possibly by other mechanisms.

20mg x 30's pack: 240.00 MRP .:. LURETIC Tab. Drug Inter.

.:. EPLERON 25 Tab. Incepta

Eplerenone INN 25mg/tablet

25mg x 20's pack: 900.00 MRP

Eplerenone has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not

overcome the effects of Eplerenone.

Ind: Congestive heart failure after an acute myocardial infarction. Hypertension. CII: Eplerenone is contraindicated in hyperkalaemia, severe renal impairment (creatinine clearance less than 30mllmin), severe

SPIRONOLACTONE2 J .26,46 SPIRONOLACTONE: Tablet/Capsule Spironolactone is a long-acting aldosterone antagonist, potassium-sparing diuretic. Mode of action: Spironolactone inhibits the reabsorption of sodium and excretion of potassium at the distal tubule by blocking the action of aldosterone. Ind: Congestive heart failure; hypertension;

hepatic impairment. Concomitant use with potent

hepatic cirrhosis; idiopathic oedema; nepbrotic

Itraconazole, Nefazodone, Troleandomycin,

thiazide & loop diuretics.

CYP3A4 inhibitors like Ketoconazole,

Claritbromycin, Ritonavir, and Nelfinavir or other potassium-sparing diuretics are also contraindicated.

SIE: Headache, dizziness, diarrhea, stomach pain, nausea, cough or flu-like symptoms may

Precautions: Eplerenone should be used with

Torasemide INN 20mg/tablet

because they have no greater effect on blood

the adrenal gland, is modulated by multiple

trouble breathing can occur.

.:. DILAST 20 Tab. Incepta

dosage of Eplerenone should be increased to

binding of aldosterone, a component of the renin

like rash, itching, swelling, severe dizziness,

hypokalemia.

Eplerenone is 50mg administered once daily.

blocker of aldosterone binding at the

occur. Symptoms of a serious allergic reaction

Corticosteroids- increment of risk of


syndrome; Conn's syndrome; potentiation of CII: Hyperkalaemia, renal failure, hepatic impairment. SIE: Hyperkalaemia, gastro-intestinal disturbances, gyneacomastia. Precautions: Potassium supplements must not be given with potassium-sparing diuretics. Administration of a potassium-sparing diuretic to a patient receiving an ACE inhibitor or an

angiotensin-I! receptor antagonist can also cause

caution in hyperkalemia, severe kidney disease,

severe hyperkalaemia.

diabetic patients with congestive heart failure

Dosage

after an acute myocardial infarction including

lOOmg daily, increasing if necessary to 400mg

& Admin: Congestive heart failure,

Torasemide INN 2.5mg & 5mgitablet

those with proteinuria.

daily; maintenance 7S-200mg daily .

2.5mg x 50's pack: 100.00 MRP

Potassium supplements must not be given with

Hypertension, SO-lOOmg daily increasing if

aldosterone antagonists.

necessary at two weekly intervals upto 200mg

5mg x 50's pack: 175.00 MRP

Pregnancy

Potassium-sparing diuretics & Aldosterone antagonists Potassium-sparing diuretics include-

Amiloride

& Triamterene. These two diuretics are weak in �ction, but, as they cause retention of potassium, they are used in combination with thiazide or

loop diuretics as a more effective alternative to potassium supplements. For details- see below with combined preparatios. Aldosterone antagonists include- Eplerenone

& Spironolactone.

EPLERENONE2J.26

& lactation: There are no adequate

and well-controlled studies in pregnant women. Eplerenone should be used during pregnancy

only if the potential benefit justifies the potential risk to the fetus. The concentration of Eplerenone in human breast milk after oral administration is unknown. Because many drugs are excreted in human milk and because of the unknown potential for adverse effects on the nursing infant, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother. Dosage

& admin: Congestive heart failure

after an acute myocardial infarction:

Children: Initially 3mg/kg body"wt. daily in divided doses. .:. VEROSPIRON Tab. Ambee Spironolactone 25mgitablet 100's pack: 202.00 MRP

Potassium-sparing diuretics with other diuretics FRUSEMIDE + SPIRONOLACTONE26,46

Eplerenone 5!1mg once daily. Treatment should be initiated at 25mg once daily and titrated to the target dose of SOmg once daily

EPLERENONE: Tablet

preferably within 4 weeks as tolerated by the

Eplerenone is a selective aldosterone antagonist

patient. Eplerenone may be administered with

and used as an adjunct in left ventricular

or without food.

dysfunction with evidence of heart failure

Hypertension: Eplerenone may be used alone

following a myocardial infarction. It is available

or in combination with other antihypertensive

as Eplerenone INN 25mg tablet.

daily.

agents_ The recommended starting dose of

FRUSEMIDE + SPIRONOLACTONE: Tablet This is a combination of two diuretics, viz: Frusemide, a short-acting loop-diuretic and spironolactone, a long-acting aldosterone antagonist, potassium-sparing diuretic. This combination produces synergistic or additive diuretic effects.

Mode of action: Frusemide inhibits the

QIMP·15 (48)


Na+/K+/2CI- co·transport in the ascending limb of loop of henle and blocks the reabsorption of

.:. EDEMIDE Tab. Acme

Frosemide 20mg & spironolactone SOmg/tablet.

electrolytes (Na+, K+ and CI· ions) and water.

30's pack: 1 80.00 MRP

Spironolactone inhibits the reabsorption of

.:. EDENIL 20 Tab. SK+F

sodium and excretion of potassium at the distal

Frosemide 20mg & spironolactone SOmgltablet.

tubule by blocking the action of aldosterone. So

30's pack: 1 80.00 MRP

the excretion of sodium is increased and the

.:. EDENIL 40 Tab. SK+F

excess loss of potassium, induced by the

Frusemide 40mg & spironolactone SOmgltablet.

frusemide is decreased.

30's pack: 240.00 MRP

Ind: i. Essential hypertension, ii. Chronic

.:. FRULAC Tab. Orion

congestive heart failure, iii. Ascites of liver


THIAZIDE + AMILORIDE21.57 THIAZIDE + AMILORIDE: Tablet Ind: Congestive heart faiLure, hepatic cirrhosis with ascites; hypertension.

CII: Hyperkalaemia, severe renal failure, pregnancy, lactation.

Adult: 1-2 tabs. daily in singLe or divided doses, increasing if necessary to max. 4 tabs. Child: Not recommended.

cirrhosis, iv. Edema (swelling due to excess fluid

SO's pack: 300.00 MRP

.:. AMIZIDE Tab. Sanofi-aventis

retention), v. Hyperaldosteronism, and vi.

.:. FRULAC 40 Tab. Orion

Hydrochlorothiazide SOmg + Amiloride

Resistant oedema associated with secondary


hydrochlor. Smgltablet.

hyperaldosteronism.

30's pack: 240.00 MRP

200's pack: 144.00 MRP

CII: This combination is contraindicated in

.:. FRUSEC Plus Tab. White Horse

.:. KALTIDE Tab. ACt

patients with acute renal failure, renal


Hydrochlorothiazide SOmg + Amiloride

insufficiency (creatinine clearance dOmVmin),

30's pack: 1 80.00 MRP

hydrochlor. Smg/tablet.

anuric states, hyperkalemia, hyponatremia,

.:. FRUSELAC Tab. Aristopharma

1 00's pack: 200.00 MRP

Addison's disease; patients with hypersensitivity


THIAZIDE + TRIAMTERINE21 ,33

to frosemide, spironolactone or sulphonamide.

30's pack: 1 80.00 MRP

SIE: Generally, this combined preparation is well

.:. FRUSELAC Plus Tab. Aristopharma

tolerated. However, a few side effects like

Frusemide 40mg & spironolactone 50mgltablet.

fatigue. nausea, vomiting. malaise or gastric

30's pack: 240.00 MRP

upset, abdominal pain, diarrhea, constipation,

.:. FRUSON-20 Tab. Ibn Sina

headache, hypotension, skin rash may be seen

Frusemide 20mg & spironolactone SOmg/tablet.

which disappears after withdrawal of the drug.

30's pack: 180.00 MRP

Besides these, irregular menstroal cycle,

.:. FUROPLUS Tab. Beacon

impotence, gynecomastia rarely may occur.


Precautions: Caution should be taken in patients

30's pack: 1 80.00 MRP

liable to electrolyte deficiency. This preparation

.:. FUROTONE Tab. Novo Healthcare

should also be used with caution in diabetes,

Frusemide USP 20mg & spironolactone USP

enlarged prostate, hypotension and in

SOmg/tablet.

hypovolemia.

30's pack: 1 80.00 MRP

Pregnancy & lactation: Frosemide is safe in

.:. FUSETON Tab. Alco Pharma

pregnancy but spironolactone may cross the


placental barrier. So, it should be used in

30's pack: ISO.OO MRP

THIAZIDE + TRIAMTERINE:Tablet Ind: Oedema; mild to moderate hypertension. Adult: Oedema, initially 1 tab. twice daily after meals, reducing to usually 1 daily or 2 on alternate days. Max. 4 daily. Hypertension, initially 1 daily. Child: Not recommended. .:. DEZIDE Tab. SK+F Hydrochlorothiazide 2Smg + Triamterine SOmg/tablet. 1 00's pack: 7S.00 MRP

.:. G-THIAZIDE T Tab. Gonoshasthaya Hydrochlorothiazide 2Smg + Triamterine SOmgltablet.

.:. FUSID Plus Tab. Square

100's pack: S I .OO MRP

mother is greater than the possible risk to the fetus.

30's pack: 1 80.00 MRP

This combined preparation is excreted into the

.:. FUSID 40 Plus Tab. Square

Carbonic anhydrase inhibitors

pregnancy only if strictly indicated & for short· term treatment and if expected benefits to the


breast milk, so it is contraindicated in lactating


mother.

30's pack: 240.00 MRP

Dosage & admin: 1 to 4 tablets daily according to the patients response or as directed by the physician. Children: Not recommended. Drug inter: Precautions should be taken while


co·administration with the following drugs: ACE


inhibitors, nephrotoxic & ototoxic antibiotics, corticosteroids, NSAIDs. carbenoxolone and sucralfate.

.:. DIRETIC Tab. Drug Inter.

.:. LACITONE Tab. General Frosemide 20mg & spironolactone SOmgltablet. 30's pack: 180.00 MRP

.:. LASILACTONE Tab. Sanofi-aventis

.:. LAXUR Tah. Healthcare Frosemide 20mg & spironolactone SOmgltablet. 30's pack: 1 80.00 MRP

.:. REDEMA 20 Tab. Rangs Pharma


Frusemide 20mg & spironolactone 50mg/tablet.

50's pack: 300.00 MRP

30's pack: 1 80.00 MRP

.:. DIRETIC-DS Tah. Drug Inter.

.:. REDEMA 40 Tab. Rangs Pharma




30's pack: 240.00 MRP

.:. DIRUCOM Tab. Popular Frosemide 20mg & spironolactone 50mg/tablet.

.:. RESITONE Tab. Beximco


30's pack: 1 80.00 IP

30's pack: L80.00 IP

.:. DIRUSID-Plus Tab. Delta

.:. TONEMIDE Tab. Pacific



30's pack: 1 79.99 MRP

30's pack: 1 80.00 MRP

.:. EDELOSS Tab. Incepta

.:. UROSPIN Tab. Bio·pharma



ACETAZOLAMIDE21.33 ACETAZOLAMIDE: Tablet Acetazolamide is a carbonic anhydrase inhibitor. It reduces bicarbonate in aqueous humour and water secreted with it. resulting in a fall in the intra-ocular pressure. hence it is used mostly by the ophthalmologist in the treatment of glaucoma. It also may be used in some other conditions.

Ind: Glaucoma, oedema, congestive cardiac failure, toxaemia of pregnancy, premenstrual tension.

CII: Renal hyperchloraemic acidosis, adrenal insufficiency; severe renal or hepatic failure; chronic closed angle glaucoma.

Caution: Gout, diabetes, pregnancy. Dosage & admin: Initially 250-375mg once daily in the morning or on alternate days. Premenstrual tension,125·375 mg as a single daily dose beginning 5-10 days before menstruation. Glaucoma, initially 500mg, subsequent doses 250mg every 6 hours. .:. ACEMOX Tab. Acme Acetazolamide 2S0mg/tablet.

30's pack: 1 80.00 MRP

SO's pack: 1 80.00 MRP

1 00's pack: I S0.00 MRP

.:. EDELOSS Plus Tab. Incepta

.:. VEROSPIRON Plus Tab. Ambee

.:. EDIMOX Tab. Gaco


Frusemide 20mg & spironolactone SOmg/tablet.

Acetazolamide 2S0mg/tablet.

30's pack: 240.00 MRP

30's pack: 1 50.00 MRP

100's pack: 1 4 1 .78 MRP

QIMP·lS (49)

CARDIOVASCULAR SYSTEM Atenolol 2Smg & amlodipine Smgltablet.

.:. REMOX Tab. Reman

heart failure, hypotension, severe peripheral

Acetazolamide 2S0mg/tablet.

vascular disease (including intennittent

30's pack: 127.S0 IP

l OO's pack: 1 1 4.00 MRP

claudication), sick sinus syndrome, cardiogenic

.:. AMLOTEN 50 Tab. Acme

shock, phaeocromocytoma (without a

Osmotic diuretics MANNIT0L21.56 MANNITOL: 10% & 20% I.V Infusion

Atenolol SOmg & amlodipine Smgltablet.

concomitant alpha blocker), metabolic acidosis.

30's pack: 13S.00 MRP

Precaution: Renal impairment: The combination

.:. AMLOVAS AT Tab. Popular

can be used in patients with renal impainnent.


However, caution may be necessary if the

30's pack: 120.00 W

creatinine clearance is less than 30mIlmin

.:. AMOCAL·AT Tab. Opsonin

because of possible reduction in the excretion of

Atenolol SOmg & arnlodipine Smgltablet.

Mannitol, a hyperosmolar solution, used as

unchanged atenolol.


dehydrating agent or to promote polyuria. It is

Hepatic impairment: Caution may be necessary

.:. AMPIL Plus Tab. White Horse Atenolol SOmg & amlodipine Smgltablet.

availalbe as 10% & 20% solution for i:v infusion.

in the use of the combination in patients with

Ind: Cerebral oedema; forced diuresis (as in to

severe liver damage because of prolongation of


prevent acute renal insufficiency of shock, in

the elimination halflife of amlodipine.

.:. AMPRE·Plus Tab. Kumudini Atenolol SOmg & arnlodipine Smgltablet.

decreased renal perfusion, in exogenic &

Bronchospasm: The combination should be used

endogenic toxicoses, in oedemas of nephrotic,

with caution in patients with airway obstruction.

30's pack: 120.00 MRP

cardiac & hepatic origin).

Drug withdrawal: Since coronary heart disease

.:. ATEPINE Tab. Pharmadesh

CII: Congestive cardiac failure, pulmonary

may exist without being recognised, patients

oedema, acute tubular necrosis, severe cardiac

should be warned against stopping the drug

decomposition.

suddenly. Any discontinuation should be gradual

S/E: Chills, fever. Cautions: extravasation may cause inflammation

Pregnancy & lactation:

& thrombophlebitis.

Dose: By i.v infusion 50·200gm over 24 hours, preceded by a test dose of 200mg/litre by slow i.v injection. Maximum l000ml (litre) per day.

and under observation. Atenolol crosses the placenta. On' the other hand,

the use of amIodipine in pregnancy and lactation has yet not been established. So, the combination is contraindicated in pregnancy and lactation.

Dosage & admin: The recommended dosage is one tablet of amlodipine 5mg and atenolol 25mg or 50mg daily. Depending upon the therapeutic response, titration of the dosage is recommended. If necessary, the dosage may be doubled to two tablets daily. In elderly patients, it is advisable to initiate the therapy with lower dosa.ge, such as, amlodipine 2.5mg and atenoloI 25mg daily. Drug inter: Given under the text of atenolol and

.:. MANISOL 20% Inj. Orion Mannitol 200gm (20%)/litre: i.v infusion. SOOml bot: 12S.00 MRP

.:. MENNITOL 20% Inj. Opso Salaine Mannitol 200gm (20%)!litre: i.v infusion. SOOml bot with set: 12S.00 MRP

.:. OSMOSOL 20% Inj. Beximco Mannitol 200gm (20%)/litre: i.v infusion. SOOml bot with set: 1 26.40 MRP

Combined antihypertensive preparations

amIodipine separately.

.:. ALOTEN Tab. Chemico

Atenolol 2Smg & amIodipine Smgltablet. SO's pack: 2 1 2.S0

ATENOLOL + AMLODIPINE48.52

MRP

.:. AMDIN PLUS Tab. Alco Pharma

Atenolol sOmg & amlodipine Smgltablet.

ATENOLOL + AMLODIPINE: Tablet


A fixed·dose combinations of atenolol and

.:. AMDOCAL Plus 25 Tab. Bexirnco

amIodipine are available for the treatment of

Atenolol 2Smg & amIodipine Smgltablet.

hypertension alone or in co·existance with

30's pack: 127.00 W

ischemic heart dease. The fixed·dose

.:. AMDOCAL Plus 50 Tab. Beximco

combinations are: i. atenolol 2Smg + amlodipine

Atenolol SOmg & amIodipine Smgltablet.

Smg and· ii. atenolol SOmg + amlodipine Smg.

60's pack: 270.30 IP

Amlodipine besilate is a dihydropyridine calcium

.:. AMICARD Plus Tab. Aexim

channel blocker and atenolol is a phenylacetamide, a selective beta, blocker.

'

Mode of action: Given under the text of atenolol and amlodipine separately.

Ind: i. Hypertension not controlled by monitherapy, ii. angina pectoris & hypertension

Atenolol sOmg & amIodipine Smgltablet. SO's pack: IS0.00 MRP

.:. AMLOBET Tab. Sun Pharma Atenolol SOmg & amIodipine Smgltablet. SO's pack: 22S.00 MRP

.:. AMLOCARD Plus·25 Tab. Drug Inter.

as co·existing diseases, iii. post·MI patients, iv.

Atenolol 2Smg & amIodipine Smgltablet.

refractory angina pectoris where nitrate has failed.

SO's pack: 22S .00 MRP

S/E: Given under the text of atenolol &

.:. AMLOCARD Plus·50 Tab. Drug Inter.

amlodipine separately.


CII: AmIodipine is contraindicated in patients

SO's pack: 2S0.00 MRP

with a known sensitivity to dihydropyridines. It

.:. AMLOCOM Tab. Beacon

should not be used in cardiogenic shock,

Atenolol sOmg & amIodipine Smgltablet.

clinically significant aortic stenosis, unstable


angina (excluding Prinzmetal's angina).

.:. AMLOSIN Plus Tab. Doctor's

Atenolol is contraindicated with a known

Atenolol SOmg & amIodipine Smgltablet.

hypersensitivity tE> atenolol, severe bradycardia,

30's pack: 1 20.00 MRP

second or third degree heart block, uncontrolled

.:. AMLOTEN 25 Tab. Acme

Atenolol SOmg & amlodipine Smgltablet. 30's pack: 1 20.00 MRP

.:. BETACAL Tab. Orion

Atenolol SOmg & amlodipine Smgltablet. SO's pack: 22S.00 MRP

.:. BPNOL·Plus Tab. Delta

Atenolol SOmg & amlodipine Smgltablet. 30's pack: 120.01 MRP

.:. CALBETA Tab. UniHealth Atenolol SOmg & amlodipine Smgltablet. 30's pack: 13S.00 MRP

.:. CALCHEK Plus Tab. General Atenolol SOmg & amlodipine Smgltablet. 30's pack: 13S.00 MRP

.:. CALOCK Plus 25 Tab. Medimet Atenolol 2Smg & amlodipine Smgltablet. SO's pack: 200.00 MRP

.:. CALOCK Plus 50 Tab. Medimet Atenolol SOmg & amlodipine Smg/tablet. SO's pack: 22S.00 MRP

.:. CALPIN Plus 25 Tab. Globe Atenolol 2Smg & amlodipine Smgltablet. 30's pack: 120.00 MRP

.:. CALPIN Plus 50 Tab. Globe Atenolol SOmg & amlodipine 5mgltablet. 30's pack: 13S.00 MRP

.:. CAMLODIN Plus Tab. Square Atenolol SOmg & amlodipine Smgltablet. 30's pack: 13S.00 MRP

.:. CAMLODIN Plus 25 Tab. Square Atenolol 2Smg & amlodipine Smgltablet. 30's pack: 1 20.00 MRP

.:. CARDIPIN Plus Tab. Renata

Atenolol SOmg & amlodipine Smgltablet. SO's pack: 22S.00 MRP

.:. COMBICARD Tab. Heaithcare Atenolol SOmg & amlodipine Smgltablet. 30's pack: 13S.00 MRP

.:. CV NOR·A Tab. Navana

Atenolol SOmg & amlodipine Smg/tablet. 30's pack: 1 3S.00 MRP

.:. DIPICARD·25 Tab. Peoples

Atenolol 2Smg & arnlodipine Smg/tablet. SO's pack: 200.00 MRP

.:. DIPLOR Plus·25 Tab. Ibn Sina Atenolol 2Smg & amlodipine Smg/tablet. 30's pack: IOS.00 MRP

.:. DIPLOR Plus·50 Tab. Ibn Sina Atenolol SOmg & amlodipine Smgltablet. 30's pack: 1 3 S .00 MRP

.:. EMLON Plus Tab. Bio·pharma Atenolol SOmg & amlodipine 5mgltablet. 30's pack: 1 20.00 MRP

QIMP.15 (50)


contraindicated in patients with sinus

.:. FIXOCARD 25 Tab. Incepta

bradycardia, heart block greater than first degree,

Atenolol 25mg & amIodipine 5mg/tablet.

and nifedipine separately.

Ind: Management of hypertension where therapy

cardiogenic shock, overt cardiacfailure & anuria.

with either a �.blocking drug or a calcium

:. FIXOCARD 50 Tab. Incepta

S/E: Atenolol and chlorthalidone combination is

channel blocker proves inadequate .

usually well tolerated. Most adverse effects have

Management of chronic stable angina pectoris

50's pack: 225.00 MRP

been mild and transient. However dizziness,

50's pack: 212.50 MRP •

Atenolol 50mg & amlodipine 5mgltablet.

.:. HIPRE Plus Tab. Pacific

fatigue, vertigo, nausea, diarrhea and bradycardia

30's pack: 150.00 MRP

Precautions & warnings: Atenolol and

have been reported rarely.


chlorthalidone combination should be given with

.:. LODICARD Tab. Aristopharma


50's pack: 225.00 MRP

where therapy with calcium channel blocker or a �·adrenoceptor blocking drug proves inadequate.

CII: This combination should not be used in

patients with any of the following conditions: Known hypersensitivity to either active

caution to patients with severe renal impairment,

component, or any other excipient or other

uncontrolled heart failure, impaired hepatic

dihydropyridines; bradycardia; cardiogenic

.:. PRISTIN-OL Tab. Novo HeaIthcare

function or liver disease. In patients receiving

shock; hypotension; metabolic acidosis; severe

thiazides, sensitivity reactions may occur with or

peripheral arterial circulatory disturbances;

30's pack: 1 20.00 MRP

without a history of allergy or bronchial asthma.

second or third degree heart block; sick sinus

systemic lupus erythematosus has been reported.

uncontrolled heart failure; women capable of


The possible exacerbation or activation of

.:. SIDOPLUS 25 Tab. SK+F


The antihypertensive effects of thiazides may be

40's pack: 170.00 MRP

enhanced in the postsympathectomy patient.

.:. SIDOPLUS 50 Tab. SK+F

Use-in elderly: Clinical studies of atenolol &


40's pack: 1 80.00 MRP

:. TENOCAB 25 Tab. ACI

•

impairment. This combination should not be used for secondary prevention of myocardial infarction .

.:. TENOCAB 50 Tab. ACI

Pregnancy & lactation: Atenolol &

50's pack: 225.00 MRP

the developing fetus and may appear in breast

from younger subjects. chlorthalidone combination can cause harm to


milk. So, it should not be given during pregnancy

.:. VASOPIN 50 Plus Tab. Silva

& lactation.


.:. VESOCAL Plus Tab. Rangs Pharma

Atenolol 50mg & amlodipine 5mgltablet. 30's pack: 135.00 MRP

ATENOLOL + CHLORTHALIDONE52 ATENOLOL + CHLORTHALIDONE: Tablet

This is a combination preparation of atenolol and chlorthalidone. Atenolol is a selective blocking agent. Chlorthalidone is a thiazide-type oral diuretic with prolonged action. The combination of atenolol & chlorthalidone offers

complementary mechanisms of action with

Prostaglandin synthetase inhibiting drugs e.g indomethacin may decrease the hypotensive

effects of beta-blockers. This combination should

BP 50mg and chlorthalidone USP 25mg, ii. tablet containing atenolol BP 100mg and chlorthalidone USP 25mg.

Mode of action: Atenolol is a cardioselective I · adrenergic receptor blocker. I n the heart .tenolol

binds with the I receptors and antagonizes epinephrine/norepinephrine, thus it blocks the adrenergic stimulation of heart muscles and decreases cardiac output. The diuretic action of chlorthalidone occurs within 2 hours of an oral

g excretion

In this way, the action of chlorthalidone also results in decrease in cardiac output. The

.

antihypertensive effects of these two agents are additive or synergistic.

Ind: This combination is indicated in the treatment of hypertension.

contraindicated in women capable of childbearing

or during pregnancy or during lactation.


dihydropyridines, e.g nifedipine, may increase

MRP

.:. CARDIPRO 50 Plus Tab. Square 30's pack: 82.50 MRP

Atenolol lOOmg & chlorthalidone 25mgltablet.

.:. TENOR-EN PLUS Tab. ACI

Atenolol 50mg & chlorthalidone 25mgltablet. 50's pack: 125.00 1P

ATENOLOL + NIFEDIPINE42 ATENOLOL-+ NIFEDIPINE: Capsule

A fixed-dose combination of atenolol and

nifedipine is available for the treatment of hypertension alone or in co·existance with ischemic heart dease. Thefixed·dose combination is- atenolol USP 5bmg + nifedipine USP 20mg presented as sustained release .capsule.

CII: This combination is contraindicated in

In .this combination, atenolol is a selective �l

sulfonamide-derived. drugs. It is also

Mode of action: See under the text of atenolol

hypersensitivity to this product or to

is given to patients with first degree heart block.

Pregnancy & lactation: This combination is

negative inotropic effects e.g verapamil,

50's pack: 150.00

of sodium and chloride, plus inhibiting

reabsorption of sodium and water in the tub.ules.

vasoconstriction. Due to its negative effect on conduction time, caution must be exercised if it

.:. CARDlPRO 100 Plus Tab. Square

.:. ATECHLOR 50 Tab. Silva

Atenolol 50mg & chlorthalidone 25mgltablet.


This combination is available in two fixed presentations, viz: i. tablet containing atenolol

Prinzmetal's angina due to unopposed alpha receptor mediated coronary artery


lithium toxicity.

.:. ATECHLOR 100 Tab. Silva

tolerability.

duration of angina attacks in patients with

Dosage & admin: Adult: Hypertension: One capsule daily swallowed with water. If necessary, the dosage may be increased to 1 capsule every 12 hours. Angina: One capsule every 12 hours swallowed with water. Where additional efficacy is necessary, prophylactic nitrate therapy or additional nifedipine may be of benefit. Elderly: Dosage should not exceed 1 capsule daily in hypertension or 1 capsule twice daily in angina. Drug inter: This combination must not be used

50's pack: 125.00 MRP

additive or synergistic effects and better

dose. It produces diuresis by increasin

combination may potentiate the action of other ahtihypertensives, such as clonidine, diltiazem.

not be given with lithium due to high risk of

(cardioselective) beta·adrenergic receptor

S/E: The following undesired events have been Cardiovascular: Flushing, edema; CNS: dizziness, headache; Gastrointestinal: gastrointestinal disturbance; Haematological: purpura; Reproductive: inpotence; Others: fatigue. Precautions: Due to its beta· blocker component reportd:

this combination may increase the number and

Dosage & admin: Dosage of this combination must be individualized. The initial dose should be one tablet (atenolol 50mg + chlorthalidone 25mg) given once a day. Drug inter: Atenolol and chlorthalidone

30's pack: 120.00 MRP

lactation; patients with clinically significant aortic stenosis; patients with marked renal

cholrthalidone combination did not include to determine Whether they respond differently

.

childbearing or during pregnancy or during

sufficient mumbers of sunjects aged 65 and over


50's pack: 200.00 MRP

syndrome; untreated phaeochromocytoma;

in conjunction with calcium channel blocker with diltiazem. Concomitant therapy with additional

the risk of hypotension, and cardiac failure may occur in patients with latent cardiac insufficiency. In this combination, atenolol and nifedipine has little effect on the pharmacokinetics of either. In

the elderly, the systemic bioavailability and

elimination half-life of both components are increased.

.:. NIDIPRO Cap. Square

Atenolol USp'50mg & nifedipine USP 20mg/capsule (sustained release). 50's pack: 1 34.50 MRP

BENAZEPRIL + AMLODIPINE26

blocker & nifedipine is a cacium·channel blocker.

BENAZEPRIL + AMLODIPINE: Capsule

QIMP-ts"(51)


This is a fixed combination preparation of

Patients with congestive heart failure: In general,

30's pack: 1 20.00 MRP

benazepril and amlodipine. The products are

all calciun channel blockers should be used with

.:. AMOCAL-BZ 1015 Cap. Opsonin

available as capsules in three presentations: i.

caution in patients with heart failure. In patients

Benazepril I Omg & amlodipine Smg/capsule.

capsule contaning benazepril hydrochloride USP

with severe congestive heart failure, whose renal

30's pack: 1 80.00 MRP

1 0mg and amlodipine besylate BP equivalent to

function may depend on the activity of the renin

.:. AMOCAL-BZ 20/5 Cap. Opsonin

amlodipine 2.Smg; ii. capsule contaning

angiotensin-aldosterone system, treatment with ACE inhibitors ,(including benazepril) may pe

Benazepril 20mg & amlodipine Smglcapsule.

benazepril hydrochloride USP IOmg and amlodipine besylate BP equivalent to amlodipine

associated with oliguria andlor progressive

20's pack: 1 60.00 MRP

.:. BENADIP 10/2.5 Cap. lncepta

Smg; iii. capsule contaning benazepril

azotemia and (rarely) with acute renal failure.

Benazepril IOmg & amlodipine 2.Smg/capsule.

hydrochloride USP 20mg and amlodipine

Patitnts with hepatic failure: Since amlodipine is


besylate BP equivalent to amlodipine Smg,

extensively metabolized by the liver, caution

.:. BENADIP 1015 Cap. Incepta

Mode of action: Benazepril inhibits angiotensin

should be exercised when administering amIodipine and benazepri( to patients with severe

20's pack: 120.00 MRP

converting enzyme (ACE). This ACE is a

Benazepril I Omg & amlodipine Smglcapsule.

peptidyl dipeptidase that catalyzes the conversion

hepatic impainnent.

of angiotensin I to the vasoconstrictor substance

Pregnancy & lactation: Caution should be

Benazepril 20mg & amlodipine Smglcapsule. 20's pack: 160.00 MRP

.:. BENADIP 20/5 Cap. Incepta

angitensin II. Angiotensin II also stimulates

exercised in first trimester of pregnancy

aldosterone secretion by the adrenal cortex.

categories C and in second and third trimesters of

Inhibition of ACE results in decreased plasma

pregnancy categories D.

.:. CACETOR 10/2.5 Cap. ACI

Benazepril 10mg & amlodipine 2.Smg/capsule.

angiotensin II, which leads to decreased

Although it is not known whether amlodipine is

24's pack: 96.00 IP

vasopressor activity and aldosterone secretion.

excreted in human, but, minimal amounts of

.:. CACETOR 1015 Cap. ACI

Mechanism through which benazepril lowers

unchanged benazepril is excreted into the breast

Benazepril I Omg" & amlodipine Smglcapsule.

blood pressure is belived to be primarily

milk of lactating mothers, so, it is recommended

24's pack: 144.00 IP

suppression of the renin-angiotensin-aldosterone

that nursing should be discontinued while

.:. CACETOR 20/5 Cap. ACI

system. Benazepril has an antihypertensive effect

amlodipine and benazepril combined

Benazepril 20mg & amlodipine Smglcapsule.

even in patients with low-renin hypertension.

preparations are administered.

24's pack: 192.00 IP

Amlodipine is a dihydropyridine calcium antagonist which inhibits the transmembrane

Dosage & admin: Amlodipine and benazepril combination therapy to be given once daily, Usual dose: In this comhination therapy amlodipine doses range from 2.Smg to 10mg and benazepril doses range from lOmg to 20mg; the physician can initiate the therapy with any fixed combination as preferred; the antihypertensive effect can be increased by increasing and adjusting the doses of amlodipine andlor benazepril in all patient groups. From this combination therapy all patients are benefited from the re

Drug inter: Bambuterol inhibits plasma

of reversible obstructive airway disease (ROAD),

should normally also be receiving regular and

such as bronchial asthma and also in bronchitis

adequate doses of inhaled anti-inflammatory

cholinesterases and can prolong the action of

and emphysema.

drugs such as suxamethonium that is inactivated

Ind: Indicated in reversible airways obstruction

drugs (e.g corticosteroids and/or in children,

by these enzymes. Bambuterol may partly or

& used in prophylaxis and control of

S/E: Cautions: See under salbutamol; important:

totally inhibit the effect of b-blockers.

bronchospasm in bronchial asthma, chronic

significant incidence of paradoxical

bronchitis, asthmatic bronchitis, pulmonary

bronchospasm, which may be clinically

emphysema, bronchiectasis, tracheo-bronchitis

important in severe or deteriorating asthma.

conversion to terbutaline.

with bronchoconstriction, other bronchospastic disorders and conditions

characterized by

bronchoconstriction. Routine maintenance therapy in chronic asthma

The once daily oral bronchodilator

sodium cromoglycate) or oral corticosteroids.

Dosage & admin: Metered dose inhalation

(2Smcgipuff or dose): By inhalation, SOmcg (2 puffs) twice daily; up to 100 mcg (4 puffs) twice daily in more severe airways

and bronchitis

obstruction. Children: Under 4 years, not

tulobuterol can cause less frequent adverse

twice daily.

S/E: Like other sympathomimetic agents reactions, such as hypertension, palpitation,

recommended, over 4 years, 50mcg (2 puffs)

Dry powder inhalation (SOmcgipuff or dose):

By inhalation, SOmcg (1 pull) twice daily; up

.:. AERODYL Tab. Silva

angina, vomiting, vertigo. central nervous system

Bambuterol hydrochloride IOmg & 20mg/tablet

stimulation, insomnia and headache.

Cautions: Tulobuterol should be used with

to l00mcg (2 puffs) twice daily in more severe

10mg x 100's pack: I SO.OO MRP 20mg x 100's pack: 300.00 MRP

caution in patients with diabetes mellitus,

not recommended, over 4 years, 50mcg (1

.:. AERODYL Syp. Silva

hypertension and hyperthyroi-dism. Caution

Bambuterol hydrochloride Smg/Sml: syrup.

should be taken in cardiac patients, especially

60ml bot: 20.00 MRP

.:. AMBUTEROL Tab. A.P.C Pharma

those with arrythmia and coronary insufficiency.

Pregnancy & Lactation: Safety of tulobuterol

Bambuterol hydrochloride IOmg/tablet

during pregnancy and lactation has not been

1 0mg x 100's pack: ISO.OO IP

established yet . It is not known whether

.:. AMBUTEROL Syp. A.P.C Pharma

tulobuterol is excreted in breast milk and or has a


harmful effect to the new born. Therefore,

60ml bot: 20.00 IP

prescription in such cases should be done

:.

•

BAMBELOR Tab. Inecpta

Bambuterol hydrochloride I Omg & 20mg/tablet IOmg x 1 00's pack: I SO.OO MRP

20mg x 1 00's pack: 300.00 MRP

.:. BAMBELOR Syp. Inecpta Bambuterol hydrochloride Smg/Sml: syrup. 60ml bot: 2S.00 MRP

:. BUTEROL Tab. ACI

•

Bambuterol hydrochloride 10mg/tablet

considering the risk benefit ratio .

Dosage & Admin: Adult, a convenient starting

IOmg x lOO's pack: 200.00 MRP 20mg x 100's pack: 3S0.00 MRP

.:. DILATOR Syp. SK+F

Bambuterol hydrochloride Smg/Sml: syrup. 60ml bot: 2S.00 MRP

:. MUTEROL Tab. Acme

•

Bambuterol hydrochloride IOmg/tablet 1 0mg x 100's pack: I SO.OO MRP

.:. MUTEROL Syp. Acme

Bambuterol hydrochloride Smg/Sml: syrup. 60ml bot: 20.00 MRP

.:. OPTIVEN Tab. Square Bambuterol hydrochloride I Omg & 20mg/tablet

200 doses unit: 190.00 MRP

.:. BEXITROL Inhaler (MDI) Beximco Salmeterol xinafoate 2Smcg/puff or dose: metered dose inhalation (MDI). 120 inhalations unit: 1 90.00

IP

.:. SALMATE Inhaler (MDI) Square

200 doses unit: 190.00 MRP

metered dose inhalation (MDI).

2mg twice daily to achieve greater effect.

Some patients however may require dosage adjustment and the adult dose may be

Other adrenoceptor stimulants

Children, 6·10 years 0.5·1mg twice daily; over

The drugs discussed under this group are

increased upto 6mg daily when needed.

twice daily; 6·12 years, l/z·1 tsf twice daily).

Bambuterol hydrochloride IOmg & 20mg/tablet

metered dose inhalation (MDI).

treatment, the dose should be increased to

Bambuterol hydrochloride Smg/Sml: syrup. 100ml bot: 3S.00 MRP

.:. AXINAT Inhaler (MDI) Acme Salmeterol xinafoate 2Smcgipuff or dose:

Salmeterol xinafoate 2Smcgipuff or dose:

10 years 1·2mg twice daily. (Who are

.:. DILATOR Tab. SK+F

pull) twice daily.

dose for adults and children of 12 years and

over, is 1 mg twice daily. After 7·10 days of

IOmg x 100's pack: ISO.OO MRP

.:. BUTEROL Syp. ACI

airways obstruction. Children: Under 4 years,

supposed to take syrup· 1·6years, 1/4, 1/2 tsf

The above recommended dosage may have to

be modified depending upon the patient response.

.:. BRETON Tab. Drug Inter. Tulobuterol hydrochloride 2mg/tablet 100's pack: 2S0.00 MRP

.:. BRETON Syp. Drug Inter. Tulobuterol hydrochloride 1 mg/Sml: syrup 60ml bot: 3S.00 MRP

Adrenaline, Ephedrine, Orciprenaline etc.

ADRENALINEZ 1.33 ADRENALINE: Injectionllnhaler

Ind: Bronchospasm, chronic bronchitis;

emergency treatment of acute anaphylaxis.

CII: Hyperthyroidism, hypertension, coronary disease

S/E: Anxiety, tremor, tachycardia, cardiac arrhythmias . Cardiac disease; diabetes; should not be used within 2 wks. of MAO inhiitors. Not to be given intravenously because of increased risk of

Long-acting selective beta2adrenoceptor stimulants

cardiac irregularities.

Dose: Bronchospasm, as a single dose by s.c. or i.m or by oral inhalation of nebu-lised solution, 200-S00 mcg. by aerosol inhalation, 280-S60 mcg. ( 1-2 puffs) upto

3-4 times daily. Acute

SALMETEROVI .33.48

anaphylaxis, by s.c. or i.m injection, O.S-Img.

SALMETEROL XINAFOATE: Metered dose

.:. ADRENALINE Inj. Waldamar

.60ml bot: 30.00 MRP

It is a long-acting adrenoceptor stimulant. It is

injection

TULOBUTEROLZ1.63

but added to existing corticosteroid and/or

IOmg x 100's pack: 200.00 MRP 20mg x 1 00's pack: 3S0.00 MRP

.:. OPTIVEN Syp. Square


inhalation (MDI)fDry powder inhalation (DPI) usually not used for the relief of an acute attack,

Adrenaline! mg in I ml ( I : 1000) ampoule: 100's pack: 236.IS MRP

N.B: Price could not be revised.

QIMP·15 (80)

RESPIRATORY SYSTEM .:. ADRENALINE Ioj. Pharmachim

and maintenance treatment of bronchospasm

worsening of narrow angle glaucoma or eye pain

associated with chronic obstructive pulmonary

may result if the aerosol is sprayed into the eyes.

injection

disease (COPD), including chronic bronchitis and emphysema.

If recommended dosage does not provide relief

loo's pack: 266.20 MRP

Adrenalinelmg in Iml ( J : 1 000) ampoule:

Preparation: May not be available

or symptoms become worse, patients should seek immediate medical attention. While taking

.:. ADRINE Inj. Gaco

IPRATROPIUM26,42

ipratropium bormide inhalation aerosol, other

injection

IPRATROPIUM BROMIDE: Oral inhalation

prescribed.

Adrenaline I mg in Iml ( 1 : 1 000) ampoule: I ampoule: S.OO MRP

EPHEDRINE2 1 .33 EPHEDRINE HCI: Tablet/Syrupl DroplIojection.

Ind: Bronchospasm, nasal congestion.

CII: Hyperthyroidism, hypertension, coronary disease, renal impairulent.

SIE: Tremor, tachycardia, insomnia, urinary retention, dry moulh cold extremities.

Mode of action: Ipratropium bromide is a synthetic quaternary anti-cholinergic parasympatholytic ammonium compound,

chemically related to atropine which appears to inhibit vagally mediated reflexes by antagonizing the action of acetylcholine- the neurotransmitter relea�ed by the vagus nerve. It is a competitive antagonist at the muscarinic acetylcholine receptors. Anti-cholinergics prevent the increases in intracellular concentration of cyclic GMP which are caused by interaction of

Caution: Cardiac diseases, diabetes. Should not

acetylcholine with the muscarinic receptors on

be given within 2 wks. of MAO inhibitors.

bronchial smooth muscle. The bronchodilation

Adult: By mouth, IS·60mg 3 times daily

Child: upto 1 yr. 7.S mg; I·Syrs, ISmg; 6· 12yrs. 30 mg; all 3 times daily.

.:. ASMAPHEN Syp. Seema Ephedrine hydrochloride I S mglSml: syrup 100ml bot: 28.00

MRP

.:. EPHEDRINE Tab. Seema Ephedrine hydrochloride 30mg/tablet SOO' pack: 149.00 MRP

.:. EPHIDIN Inj. Popular

Ephedrine hydrochloride 2SmglSml ampoule: injection 10 amps pack: 1 20.00 MRP

.:. FEDRIN Tab. Jayson

Ephedrine hydrochloride 30mgltablet 1000' pack: 2S0.00 IP

:. FEDRIN Inj. Jayson

•

Ephedrine hydrochloride 2SmglSmi ampoule: injection 10 amps pack: 1 20.00 IP

: G·EPHEDRINE Ioj. Gonoshasthaya

•.

Ephedrine hydrochloride 2SmglSml ampoule: injection S amps pack: 60.00 MRP

:. NORDRINE Inj. Incepta

•

Ephedrine hydrochloride 2SmglSml ampoule: injection 1 0 amps pack: 1 20.00 MRP

following oral inhalation or nasal spray of ipratropium bromide is primarily a local, site specific effect, not a systemic one.

Ind: As bronchodilator in treatment of chronic reversible airway obstruction as in asthma and chronic obstructive pulmonary disease (COPD) including chronic bronchitis and emphysema. Treatment of acute reversible airways obstruction. Ipratropium bromide inhalation aerosol or nasal spray is not indicated for the initial treatment of acute episodes of bronchospasm where rapid response is required.

CII: Konwn hypersensitivity to ipratropium

bromide, atropine or its derivative. Also contraindicated in patients with a history of hypersensitivity to soya lecithin or related food products such as soybean, lecithin and peanut.

SIE: Idiosyncratic reactions to ipratropium

bromide are rare. Severe adverse effects due to inhibition of muscarinic receptors and ganglion

inhaled drugs should not be used unless Immediate hypersensitivity reactions may occur after administration of ipratropium bromide, as demonstrated by rare cases of urticaria, angiooedema, rash, bronchospasm and oropharyngeal oedema.

Dosage & admin: For oral inhalation/nasal spray only. Adults- the usual dose is 1-2

puffs/spray 3 or 4 times daily. Single dose up

to 80mcg (4 puffs or spray of 20mcglpuff or 2

puffs of 4Omcglpuff) may be required to obtain' maximum benefit during early

treatment. Patients may take additional

inhalations as required; however, the total number of oral inhalations or nasal spray

should not exceed 12 puffs (20mcglpuff) or 6

puffs (40mcglpuff) in 24 hours.

Children· 6 to 12 years- usually 1·2 puffs or

spray (20mcglpuff) 2 to 3 times daily. Below 6

years· the usual dose is 1 puff or spray

(20mcg) 3 times daily. In order to ensure that

the inhaler is used correctly, administration should be supervised by an adult.

On clinical trials, no specific information &

adverse reactions on the use of the product in the elderly is available.

Drug inter: Ipratropium bromide has been used concomitantly with other drugs, including

sympathomimetic bronchodilators, methylxanthines, steroids and cromolyn sodium, commonoy used in treatment of COPD, without any adverse drug reactions .

.:. G·IPRA Respirator Soln. Gonoshasthaya

Ipratropium bromide 2S0mcglml: Respirator

blockade are theoretically possible but unlikely

solution for inhalation.

with the metered-dose aerosol.

20ml vial: 60.00 MRP

Regular use of ipratropium can lead to a dry

.:. IPRAMID Inhalar Beximco

mouth through inhibition of salivary flow. Other common adverse reactions reported are

Ipratropium bromide

20mcg/puff (spray): oral

inhalar.

dryness of the mouth & oropharynx, nausea,

Each canister of Ipramid inhaler contains 4mg of

dizziness, blurred vision/difficulty in

ipratropium bromide BP.

accommodation & drying of secretions.

200 puffs inhalar: 200.00 IP

Less frequently reported adverse reac-tions include tachycardia, nervousness, paresthesia, drowsiness, co-ordination difficulty, itching,

.:. IPREX Inhalar Square

Ipratropium bromide 20mcglpuff (spray): oral

inhalar.

Antimuscarinic bronchodilators21

hives, flUShing, alopecia, constipation, tremor &

Each canister of Iprex inhaler contains 4mg of

mucosal ulceration.

ipratropium bromide BP.

Case of precipitation or worsening of narrow

200 puffs inhalar: 200.00 MRP

Antimuscarinic bronchodilators are more

angle glaucoma, acute eye pain & hypotension

effective in chronic obstructive pulmonary disease rather than in relieving asthma. Ipratropium & oxitropium may be used by inhalation in the management of chronic asthma in patients who already require high·dose inhaled corticosterodis. Ipratropium by nebulisation may be added to other standard treatment in life

threatening asthma or where acute asthma fails

p

to improve with standard therapy. Tiotro ium is a long-acting, antimuscarinic agent, which is often referred to as an anticholinergic. It has similar affinity to the subtypes of muscarinic receptors. It is indicated

for the long-term, once-daily approach to manage

also have been reported.

.:. IPREX Respirator Solo. Square

Ipratropium bromide 250mcglml: Respirator

Allergic-type reactions such as skin rash, angio

solution for inhalation.

oedema of tongue, lips

20ml pack: 1 30.00 MRP

& face, urticaria

(including giant urticaria), laryngospasm and anaphylactic reaction have also been reported; with positive rechallenge in some cases. Ipratropium bromide does not produce adverse

TIOTROPIUM42 TIOTROPIUM BROMIDE: DPIIMDI

effects on mucocilliary clearance, in contrast to

Tiotropium is a long-acting antimuscarinic

atropine and other muscarinic antagonists.

bronchodilator. It is available as dry powder

There is no evidence that in the therapeutic dose

inhalation (DPI) & metered dose aerosol

range ipratropium bromide has any adverse effect

inhalation (MOl).

on bronchial secretion.

DP/: Tiotropium bromide monohydrate INN

temporary blurring of vision, precipitation or

oraI,inhaiation only.

Precaution: Patients should be advised that

1 8mcgIRotacap. Dry powder inhalation is for

QIMP-J5 (8I)

RESPIRATORY SYSTEM

inhibition of M3-receptors at the smooth muscle

adjustment of tiotropium dosage in geriatric patients is warranted. Children below 12 years: Not recommended. DPI or Dry powder inhalation is for oral inhalation only. Rotahaler device is used for dry powder inhalation. Rinsing the mouth after dry powder inhalation is advised. Drug inter: Tiotropium has been used

leading to bronchodilation. The bronchodilation

concomitantly with other drugs commonly used

Cardiovascular symptoms- palpitation,

following inhalation of tiotropium is

in COPD without increases in adverse drug

tachycardia, hypotension, circulatory failure,

predominantly a site-specific effect.

reactions. These include sympathomimetic

Ind: Tiotropium bromide is indicated for the

bronchodilators, methylxanthines, and oral and

long-term, maintenance treatment of

inhaled steroids. However, the co-administration

ventricular arrhythmias, and flushing; Renal symptoms- albuminuria, diuresis and hematuria; Others- hyperglycemia, tachypnea and

MDI: Tiotropium bromide monohydrate INN 9mcg/puff; Metered dose aerosol inhalation (MOl).

Mode of action: Tiotropium is a long-acting, antimuscarinic agent, which is often referred to as an anticholinergic. It has similar affinity to the subtypes of muscarinic receptors, M 1 to MS. In the airways, it exhibits it's effects through

toxicity; however, with high doses, ventricular anhythmias or seizures may be the tlrst signs to appear. Adverse reactions include:

Gastrointestinal symptoms- such as nausea, vomiting, epigastric pain, hematemesis, dianhoea, anorexia, intestinal bleeding and reactivation of peptic ulcer;

CNS symptoms

headache, irritability, restlessness, insomnia, twitching, convulsion &reflex hyperexcitability;

bronchospasm associated with chronic

of tiotropium with other anticholinergic

inappropriate ADH syndrome.

obstructive pulmonary disease (COPD),

containing drugs (e.g ipratropium) has not been

Precautions: Aminophylline should be given

including chronic bronchitis and emphysema.

studied and is therefore not recommended.

with caution to patients with peptic ulceration,

CIl: Tiotropium is contraindicated in patients with a history of hypersensitivity to atropine or its derivatives, including ipratropium, or to any component of the product.

SIE: The most commonly reported adverse reaction was dry mouth; it was usually mild and often resolved during continued treatment. Other reactions reported include constipation. increased heart rate, blurred vision, glaucoma, urinary difficulty, and urinary retention.

Precaution: As an anticholinergic drug, tiotropium may potentially worsen symptoms and signs associated with narrow-angle glaucoma, prostatic hyperplasia or bladder neck obstruction and should be used with caution in patients with any of these conditions. As a predominantly renally excreted drug, patients with moderate to severe renal impainnent treated with tiolropium should be monitored closely. Eye pain or discomfort, blurred vision. visual halos or colored images in congestion and corneal edema may be signs of acute narrow angle glaucoma. Should any of these signs and symptoms develop, consult a physician immediately. Miotic eye drops alone are not considered to be effective treatment.

Pregnancy & lactation: Tiotropium should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. The safety and effectiveness of tiotropium has not been studied during labor and delivery. Clinical data from nursing women exposed to tiotropium are not also available, so, caution should be exercised if tiotropium is administered to a nursing mother.

Dosage & admin: Metered dose illhalatioll (MDI): Adults and adolescents 12 years & older: The recommended dosage of tiotropium bromide is the inhalation of 2 puffs (9mcg/puff) once daily for the maintenance treatment of bronchospasm associated with COPD. No adjustment of tiotropium dosage in geriatric patients is warranted. Children below 12 years: Not recommended. MOl or Metered dose inhaler is to be used by aerosol inhalation only. Dry powder illhalation (DPI): Adults and adolescents 12 years & older: The recommended dosage of tiotropium bromide is the inhalation of I Rotacap (18mcgIRotacap) once daily for the maintenance treatment of bronchospasm associated with COPD. No

.:. NORVENT Inhaler (MOl) Square Tiotropium bromide monohydrate INN 9mcg/puff: Metered dose inhalation (MOl). 120 puffs unit: 350.00 MRP

.:. TOPIUM Inhaler (DPI) Acme Tiotropium bromide monohydrate INN 18mcglRotacap: Dry powder inhalation (DPI). 30 Rotacaps pack: 1 50.00 MRP

.:. TRIOMID Inhaler (MOl) Beximco Tiotropium bromide monohydrate INN 9mcg/puff: Metered dose inhalation (MDI). 120 puffs unit: 350.00 MRP

hyperthyroidism, hypertension, cardiac arrhythmias or other cardiovascular diseases, or epilepsy, as these conditions may be exacerbated. It should also be given with caution to patients with heart failure, hepatic dysfunction, chronic alcoholism, acute febrile illness, and to neonates and the elderly, since in all of these circumstan ces theophylline clearance may be decreased, resulting in increases in serumtheophylline concentrations and serum half-life,

Pregnancy & lactation: Theophylline crosses the placental barrier and also passes freely into breast milk, where concentrations are similar to plasma levels. Safe use in pregnancy has not

Theophylline & related drugs21

been established relative to possible adverse effects on fetal development. Therefore, use of aminophylline in pregnant women should be

Theophylline is a methylxanthine derivative,

weighed against the risk of uncontrolled disease.

used as bronchodilator to treat moderate to

Dosage: By mouth: Adult, initially 100-200mg 2-3 times daily for one week, then maintenance 200-600mg twice daily. Child, under I year not recommended; over I year 12mg/kg body-wt. twice daily. Special tablet preparatiolls (LAlRtd tablet): See below under individul product. Note: Tablets should be swallowed whole and not chewed because of the structure of the tablet. By illjections: Adult, 125-250mg by slow (over 10-15 mins) i.v injection, usually given in 5% dextrose in aqua or normal saline. (rapid injection may result in cardiac arrest). Children, 2-3mg/kg 2-3 times daily by very slow i.v injection. By rectum in suppositories: Adult, 360mg once or twice daily. Child, once or twice daily, upto. I yr. 12.5-25mg; 1-5 yrs. 50-100mg; 6-12 yrs. 100-200mg. Drug inter: Beta-blockers (e.g propranolol) may

severe reversible brancho-spasm that occurs in asthma or chronic obstructive pulmonary disease (COPD). Theophylline is given by injection in its salt form as aminophylline, a mixture of theophylline with ethylenediamine, which is about 20 times more soluble than theophylline alone, but have no major therapeutic advantage. Aminophylline thus contains about 85% theophylline.

AMINOPHYLLINE21 ,48 AMINOPHYLLINE: TabletlInjection! Suppos. Aminophylline BP is a stable mixture or combination of theophylline and ethylenediamine. Ethylenediamine confers greater solubility in water.

Ind: It is indicated for the treatment and prophylaxis of bronchospasm associated with asthma, emphysema and chronic bronchitis. Also indicated in adults for the treatment of cardiac asthma and left ventricular or congestive cardiac

oppose the effects of aminophylline, Barbiturates, phenytoin and smoking may decrease theophylline levels in blood or circulation.

failure.

.:. AMINOPHYLLINE Tab. Ambee

CIl: Aminophylline should not be administered

Aminophylline 1 00mgltabiet

to patients with hypersensitivity to xanthines or

500's pack: 190.00 MRP

ethylenediamine. It should not be administered to

.:. AMINOPHYLLINE Inj. Ambee

patients with active peptic ulcer, since it may increase the volume and acidity of gastric

Aminophylline I 25mg/5ml ampoule: injection 5 amps pack: 27.25 MRP

secretions.

.:. AMINOPHYLLINE Tab. Bristol

S/E: The most common adverse effects are

Aminophylline 100mg/tabiet

gastric irritation, nausea, vomiting, epigastric

200's pack: 190.00 MRP

pain and tremor. These are usually early signs of

.:. AMINOPHYLLINE Tab. Chemist

RESPIRATORY SYSTEM

QIMP-15 (82)

Aminophylline lOOmgltablet

SIE: The following side effects have been

.:. AMINOPHYLLINUM Rtd. Tab. Sandoz! Novartis

insomnia, muscles twitching; Palpitation,

Dosage & admin: The recommended initial

Tachypnoea; Potentiation of diuresis. Others:

SOO's pack: 1 90.00 MRP

Aminophylline 3SOmgltabiet (retard)

dose

is 1

tablet (350mg) every 12 hours. The

dosage may be gradually increased to a

maximum of 2 tablets (700mg) twice a day depending on the patients response. SO's pack: 1 I l .00 MRP

observed: Nausea, vomiting, epigastric pain and

diarrhoea; Headache, irritability, restlessness,

tachycardia, hypotension, circulatory failure;

Alopecia, hyperglycemia, rash etc.

Precautions: Theophylline should not be

administered concurrently with other xanthine.

Use with caution in patients with hypoxemia,

hypertension, or those with history of peptic

ulcer. Do not attempt to maintain any dose that is

.:. BROLIN Rtd. Tab. Delta Aminophylline 3S0mgltablet (retard)

not tolerated.

dose is 1 tablet (350mg) every 12 bours. The

whether theophylline can cause fetal harm when


dosage may be gradually increased to a

Pregnancy & lactation: It is also not known

administered to a pregnant woman or can affect

maximum of 2 tablets (700mg) twice a day

reproduction capacity. Xanthine should be given


Theophylline is excreted into breast milk and

lOO's pack: 38.00 MRP

mother only if clearly needed.

depending on tbe patient?s response. .:. FILIN Tab. Opsonin Aminophylline lOOmgltablet

.:. FILIN lnj. Opsonin Aminophylline 1 2SmglSmI ampoule:injection 10 amps pack: 44.00 MRP

·:·:LARNOX.LA Tab. Beximco Aminophylline BP 3S0mgltablet (sustained release-long acting).


dose

is 1 tablet (350mg) every 12 hours. The be gradually increased to a

dosage may

maximum of 2 tablets (7oomg) twice a day

to a pregnant woman only if clearly needed.

may cause irritability or other signs of toxicity in nursing infants. So, it should be given to nursing

Dosage & admin: Dosages are adjusted to

maintain serum theophylline concentrations

tbat provide optimal relief of symptoms with

minimal side effects. The recommended

dosages for achieving serum theophylline

concentrations witbin the accepted therapeutic range are as following:

Adult: 125·250mg 3·4 times daily. Children: 1·6 months, IOmg/kglday; 6

(sustained release).

30's pack: 80. 1 0 MRP

.:. CONTINE Syp. Aristopharma Theophylline sodium glycinate 1 20mg/Sml: syrup 100ml bot: 23.77 MRP

.:. EOFYLIN SR Cap. Salton Theophylline sodium glycinate USP 300mg/capsule. (sustained release). 100's pack: 293.00 MRP

.:. EOFYLlN Syp. Salton Theophylline sodium glycinate 1 20mg/Sml: syrup 100ml bot: 2S.00 MRP

.:. G·THEOPHYLLINE Tab. Gonoshastha Theophylline sodium glycinate 300mgltablet lOO's pack: 8 l .00 MRP

.:. G· THEOPHYLLINE Syp. Gonoshastha Theophylline sodium glycinate 1 20mg/Sml: syrup 1 00ml bot: 13.70 MRP

.:. JASOPHYLIN Tab. Jayson Theophylline sodium glycinate 300mgltablet lOO's pack: 1 30.00 MRP

.:. JASOPHYLIN Syp. Jayson Theophylline sodium glycinate 1 20mg/Sml: syrup 100ml bot: 2S.00 MRP

.:. NEONATE Syp. Skylab Theophylline sodium glycinate 1 20mg/Sml: syrup 50ml bot: 13.70 MRP

.:. TEOLEX CR 300 Cap. ACI Theophylline sodium glycinate 300mglcapsule. (controlled release).

SO's pack: 17S.00 IP

depending on tbe patient?s response.

24mg/kglday; 10·16 years, 18mg/kglday, in 3·4

.:. TEOLEX CR 400 Cap. ACI Theophylline sodium glycinate 400mglcapsule.

.;. MINOMAL R Tab. Pacific Aminophylline 175 & 350mgltablet (retard)

Drug inter: Allopurinol, cimetidine,

SO's pack: 2 1 l .S0 IP

350mg x 50's pack: 1 10.00 IP


idoSe is 1 tablet (350mg) every 12 horus. The

months· 1 year 15mg/kglday; 1·9 years,

divided doses.

(controlled release).

ciprofloxacin, erythromycin, lithium carbonate,

.:. THENGLATE SR Tab. Acme Theophylline sodium glycinate 2S0mg &

oral contraceptive, propranolol increases serum theophylline level when administered

400mgltablet. (sustained release).

. maximum of 2 tablets (7oomg) twice a day

theophylline level.

400mg x 50's pack: 1 33.S0 MRP

' 't75rhg x lOO's pack: 1 23.00 MRP

approximately equivalent to 1 . 1 gm theophylline

. dOsage may be gradually increased to a depending on the patients reSponse. 350mg x SO's pack: 1 10.00 MRP

:. MINOMAL.R SR Tab. Pacific

concomitantly and rifampicin decreases serum

N.B: 2 gm of theophylline sodium glycinate is

anhydrous .

•

Aminophylline dihydrate 600mgltablet

Administration on a full stomach is advised.

l OO's pack: 1 3 1 .00 MRP


.:. THEONATE Syp. Doctors Theophylline sodium glycinate 120mg/Sml: syrup SOml bot: 15.20 MRP

.:. ltEsTOPHYLLINE Tab. Gaco Aminophylline lOOmgltablet 1 00's pack: 38.43 MRP

. ,

TablWCapsulelSyrup

�tructUrally theophylline is a xanthine derivative. Ii is available in tablet,

capsule & syrup form.

MMe of action: Theophylline is a

lOOnI! bot: 23.77 MRP

.:. THEOGLATE Syrup CPL Theophylline sodium glycinate 120mglSml: syrup .:. THEONATE Tab. Doctors. Theophylline sodium glycinate 300mgltablet.

otberWise directed by the doctor.

THEOPHYLLINE Sodium Glycinate:

.:. THENGLATE Syp. Acme Theophylline sodium glycinate 120mglSml: syrup

50ml bot: 1 2.00 MRP

(sustained release ).

DOsage: 1/2 ·1 tablet every 12 hours, unless

THEOPHYLLINE Sodium Glycinate21,36

2S0mg x SO's pack: 87.S0 MRP

100ml bot: 2S.00 MRP

:. AROFIL 300 SR Tab. Incepta Theophylline sodium glycinate 300mg/tablet.

•

.:. THEOVENT Cap. Drug Inter. Theophylline sodiun glycinate 300mglcapsule



:. AROFIL 400 SR Tab. Incepta Theophylline sodium glycinate 400mgltablet.

.:. THEOVENT SR Tab. Drug Inter. Theophylline sodium glycinate 400mgltablet.

SO's pack: 133.50 IP

50's pack: 133.S0 MRP

SO's pack: 100.00 IP •


l00's pack: 292.00 MRP


.:. ASMAIN Syp. Edruc Theophylline sodium glycinate 120mg/SmI: syrup

.:. UNIKON Syp. Ibn Sina Theophylline sodium glycipate 1 20mglSml: syrup

aiiwltys and pulmonary blood vessels.

1 00ml bot: 25.00 MRP

1 00nI! bot: 2S.00 MRP

prevention of symptoms from asthma and

.:. ASMANYL 300 SR Tab. Square Theophylline sodium glycinate 300mgltablet.

THEOPHYLLINE Anhydrous21,36

100's pack: 196.00 MRP

THEOPHYLLINE ANHYDROUS:

brlmcl1odiiator. It directly relaxes the smooth

�'rnlisde o'r the bronchial airways, pulmonary

Ind: Theophylline'is indicated for relief and/or n:vetsihle bronchospasm associated with chronic btonchitis and emphysema.

Cn:

Kriown hypersensitivity to its components;

patients, �ith active Peptic iIlcer disease.


.:. ASMANYL 400 SR Tab. Square Theophylline sodium glycinate 400mgltablet.

Tablet/Capsule

Ind: Bronchospasm associated with asthma, ch.

QIMP-15 (83)

bronchitis, emphysema.

CII; SIE; Cautions: See above under the text of

RESPIRATORY SYSTEM

It is not known whether the components of

place. The drug does not inhibit the binding of

salbutamol & ipratropium bromide combination

IgE to mast cells, nor the interaction betweel)

'theophylline sodium glycinate'.

inhalation aerosol are excreted in human milk.

cell bound IgE and the specific antigen; instead,

Pregnancy & lactation: See above under the text

However, because many drugs are excreted in

sodium cromoglycate suppresses the release of

of 'theophylline sodium glycinate'.

human milk, caution should be exercised when

substances (e.g histamine, SRS-A) in response to

salbutamol & ipratropium bromide combination

this reaction. The drug also inhibits type-ill (late

Dosage: Adult, over SOkg 2S0-300mg ( ltab.)

twice daily in the morning & evening. Adults with low body weight & adolescents, half the

inhalation aerosol is administered to a nursing

allergic, arthus) reactions to a lesser extent: Th�

mother.

action of sodium cromoglycate on the mast cell

Children: 10-lSmglkg given in 2 divided doses

and adolescents over 12 years of age): The

since the drug has also

adult dose (112 tab.) 2-3 times daily.

at 12 hours intervals. It is better taken after

i

Dosage & admin: Adults (including the elderly

dose of this combined inhalation ae�sol is 2

been shown to inhibit secretion induced by other

additional inhalations as required; however,

48/80). Bronchial asthma induced by the

meals with a little water. It is su table for

puffs 4 times a day. Patients may take

Drug inter: See above under th,e text of

the total number of inhalations should not

longterm administration.

'theophylline sodium glycinate·.

is not restricted to antigen-evoked secretion,

exceed 12 in 24 hours.

mast cell secretagogues (e.g the pOlyamine

inhalation of antigens can be inhibited to varying degrees by sodium cromoglycate pre

Children (below 12 years): Not recommended.

treatment.Sodium cromoglycate acts locally on

Theophylline anhydrous 400mgltablet (sustained

.:. IPRASOL Inhaler (MDn Beximco

inhalation.

release).

Each single actuation or puff of this inhalation

:. ASMACON SR Tab. Pacific

•

50's pack: 1 33.50 MRP

aerosol delivers 1 00mcg of salbutamol BP &

:. CONTINE-400 Tab. Aristopharma Theophylline anhydrous 400mgltablet (in

20mcg of ipratropium bromide BP .

•

200 puffs unit: 230.00 IP

the lungs to which it is directly applied by

Ind: Prophylaxis of bronchial asthma; prevention of exercise-induced asthma. Children seem to response better than adults.

I! has no value in the treatment of acute· attack

continuous controlled release system).

.:. SALPIUM Inhaler (MDI) Acme Each single actuation or puff of this inhalation

of asthma.

two times, give once daily.

aerosol delivers l oomcg of salbutamol BP &

loo's pack: 267.00 MRP

20mcg of ipratropium bromide BP .

to sodium cromoglycate or to any of its

.:. QUmORN-T/SR Tab. Squibb/ Kapricorn Theophylline anhydrous 300mg/tablet

200 puffs unit: 230.00 MRP

Dose: See above under the text; but instead of

(timed/sustained release).

.:. SULPREX Inhaler (MDI) Square Each single actuation or puff of this inhalation

l oo's pack: 546.00 MRP

aerosol delivers 1 00mcg of saibutamoi BP & 20mcg of ipratropium bromide BP .

Compound bronchodilator prepns_ SALBUTAMOL + IPRATROPIUM42,48 SALBUTAMOL + IPRATROPIUM

BROMIDE: Metered dose inhalation (MOl) This is a combined metered dose inhalation formulation of two components- salbutamol, a 2 adrenergic bronchodilator and ipratropium bromide, an anti-cholinergic bronchodilator. Each single actuation of this inhalation aerosol delivers 20 g of ipratropium bromide BP and 100 g of salbutamol BP.

200 puffs unit: 225.00 MRP

.:. SULPREX Refill Square Each single actuation or puff of this refill aerosol delivers l oomcg of salbutamol BP & 20mcg of ipratropium bromide BP . 200 puffs refill: 200.00 MRP

2. PROPHYLACTICS OF

ASTHMA2 1

2.1 Cromoglycate & related drugs: such as,

Sodium cromoglycate, Nedocromil sodium

& related drug such as, ketotifen.

2.2 Leukotriene receptor antagonists: such as, Montelukast, Zafirlukast.

Ind: This combined inhalation aerosol is

indicated for use in patients with chronic obstructive pulmonary disease (COPD) on a regular aerosol bronchodilator who continue to have evidence of bronchospasm and who require a second bronchodilator.

CII: See above under the text of ,saIbutamol' & 'ipratropium bromide' separately.

SIE; Precautions: See above under the text of

Cromoglycate & Related drugs SODIUM CROMOGLYCATE21.33.42 SODIUM CROMOGLYCATE: Aerosol Spray

CII: Patients who

have shown hypersensitivity

components. I! is not indicated as the primary treatment of status asthmaticus or other acute episodes of asthma where intensive measures are required.

SIE: Coughing, transient bronchospasm & throat irritation due to inhalation of powder. Precautions: The �ecommended dosage should be decreased in patients with renal or hepatic dysfunction. Where a concomitant bronchodilator is prescribed, it is recommended that this

be

administered prior to the sodium cromoglycate inhalation. In patients currently treated with steroids, the

addition of sodium cromoglycate inhalation to the regimen may make it possible to redu�e the maintenance dose or to discontinue steroid completely. The patient must be carefully

supervised while the steroid dose is reduced; a

rate of reduction of 10% weekly is suggested. If reduction of steroid dosage is possible, sodiurn cromoglycate inhalation should not be withdrawn until steroid cover has heen re-instituted. Since the therapy is prophylactic, it is importal)t to continue therapy in those patients who get benefit. If it is necessary to withdraw this treatment, it should be done gradually over a period of one week.

Pregnancy & lactation: As with all medication, caution should be exercised specially during the first trimester of pregnancy. Cumulative

'salbutamol' & 'ipratropium bromide' separately.

Introduction & mode of action: Sodium

experience with sodium cromoglycate suggests

cromoglycate is an antiasthmatic, antiallergic and

that it has no adverse effects on foetal

and well-controlled studies of salbutamol &

mast cell stabilizer. I! has no intrinsic

development. However, it should only be used in

ipratropium bromide combination inhalation

bronchodilator, antihistaminic, vasoconstrictor or

pregnancy where there is a clear need.

aerosol in pregnant women. So, the use of this

anti-inflammatory activity. I! prevents release of

I! is not known whether sodium

combination aerosol product for the treatmnt of

the mediators of type-I allergic reactions,

cromoglycate is excreted in the breast milk,

COPO during pregnancy and labor should be

including histamine and slow reacting substance

there is also no evidence that the use of sod,iu.m

restricted to those patients in whom the benefits

of anaphylaxis (SRS-A) from sensitized mast

cromoglycate has any undesirable effects on the

clearly outweigh the risk to the fetus.

cells after the antigen-antibody reaction has taken

breast-fed baby.

Pregnancy & lactation: There are no adequate

Su lprex ® Salbutamol + Ipratropium

Inhale r

More than a bronchodilator for Asthma & COPD

QIMP-IS (84)

RESPIRATORY SYSTEM

Dose: By aerosol inhalation, adults & children- 10mg (or 2 puffs) 4 times daily initially at regular intervals in spinhaler, increasing in severe cases or duringperiods of risk to 6-8 times daily_ Before exercise, additional doses may be taken_ Maintenance, 5mg(1 puff) 4 times daily_ Therapy should be continuous. By inhalation of powder, adults & children20mg 4 times daily, increased in severe cases to 8 times daily_ By inhalation of nebulised solution, adults & children- 20mg 4 times daily, increased in severe cases to 6 times daily_ .:. INTAL 5 Inhaler Sanofi-aventis Sodium cromoglycate 5mg/inhalation; 1 1 2 inhalations unit: spin inhaler. 1 1 2 inhalations unit: 5 1 5.00 MRP

KETOTIFEN21.JJ

100's pack: 152.00 IP

.:. ZADIT Syp. Popular

:. KETOF Syp. Ibn Sina

Ketotifen fumerate I mg/Sml: syrup .

•

Ketotifen fumerate I mg/5ml: syrup.

.:. KETOMAR Tab. Incepta Ketotifen fumerate

I mg/tablet.

100's pack: 150.00 MRP

.:. KETOMAR Syp. Incepta Ketotifen fumerate I mg/5ml: syrup. 1 00ml bot: 40.00 MRP

.:. KETOTIF Tab. Delta Ketotifen fumerate I mg/tablet. 1 00's pack: 1 49.99 MRP

.:. KETOTIF Syp. Delta Ketotifen fumerate I mg/5ml: syrup. 100ml bot: 35.01 MRP

.:. KOFEN Tab. Opsonin Ketotifen fumerate I mg/tablet. 100's pack: 150.00 MRP

.:. KOFEN Syp. Opsonin Ketotifen fumerate I mg/5ml: syrup. 1 00ml bot: 35.00 MRP

KETOTIFEN: Tablet Ind: Prophylaxis of bronchial asthma;

Ketotifen fumerate I mg/5ml: syrup.

symptomatic relief of allergy such as hay fever,

1 00mi bot: 40.00 MRP

urticaria.

.:. PROSMA Tab. ACI

CII: Concurrent adin. of oral hypoglycaemics. SIE: Dry mouth, sedation. Cautions: Alertness may be impaired; avoid alcohol; previous anti-asthmatic treatment should

.:. MINIA Syp. Novo "ealthcare

Ketotifen fumerate I mg/tablet. l OO's pack: 1 50.00 MRP

.:. PROSMA Syp. ACI

Ketotifen fumerate Img/5ml: syrup.

be continued for a minimum of 2 weeks after

100ml bot: 40.00 MRP

initiation of ketotifen treatment.

.:. STAFEN Tab. Aristopharma

Adult: 1-2 mg twice daily with food. Child: Under 2 years, not recommended; over 2yrs. I mg twice daily with food. :. AEROFEN Tab. Silva Ketotifen fumerate I mg/tablet. •


: AEROFEN Syp. Silva

•.

Ketotifen fumerate I mg/5ml: syrup. 1 00ml bot: 35.00 MRP

:. ALARID Tab. Square

•

Ketotifen fumerate I mg/tablet. 1 00's pack: 150.00 MRP

.:. ALARID Syp. Square Ketotifen fumerate I mg/5ml: syrup. 100ml bot: 40.00 MRP

.:. BROKET Tab. Orion Ketotifen fumerate I mg/tablet. 100's pack: 1 50.00 MRP

.:. BROKET Syp. Orion Ketotifen fumerate I mg/5ml: syrup. 100ml bot: 40.00 MRP

.:. FENAT Tab. Drug Inter. Ketotifen fumerate I mg/tablet. 100's pack: 150.00 MRP

.:. FENAT Syp. Drug Inter. Ketotifen fumerate I mg/5ml: syrup. 100ml bot: 36.00 MRP

.:. KETIFEN Tab. Acme Ketotifen fumerate I mg/tablet. 100's pack: 1 50.00 MRP

: KETIFEN Syp. Acme

•.

Ketotifen fumerate I mg/5ml: syrup. 100ml bot: 40.00 MRP

.:. KETODIL Cap. Techno Drugs Ketotifen fumerate I mg/capsule. 50's pack: 75.00 MRP

:. KETOF Tab. Ibn Sina

•

Ketotifen fumerate I mg/tablet.

1 00ml bot: 40.00 IP

1 00ml bot: 40.00 IP

Ketotifen fumerate I mg/tablet. 100's pack: 150.00 MRP

.:. STAFEN Syp. Aristopharma Ketotifen fumerate I mg/5ml: syrup. 100ml bot: 40.00 MRP

.:. TIFEN Tab. Somatec

Ketotifen fumerate I mg/tablet. 1 00's pack: 1 50.00 IP

.:. TlFEN Syp. Somatec

Ketotifen fumerate I mg/5ml: syrup. 1 00m I bot: 37.00 IP

.:. TOFEN Tab. Beximco Ketotifen fumerate I mg/tablet. 200's pack: 300.00 IP

.:. TOFEN Syp. Beximco Ketotifen fumerate I mg/5ml: syrup. 1 00ml bot: 40.00 IP

.:. TOMA Tab. Navana Ketotifen fumerate I mg/tablet. 1 00's pack: 150.00 IP

.:. TOMA Syp. Navana Ketotifen fumerate I mg/5ml: syrup. 1 00ml bot: 35.00 IP

.:. TOTI Tab. SK+F Ketotifen fumerate I mg/tablet. 1 00's pack: 1 50.00 MRP

.:. TOTI Syp. SK+F Ketotifen fumerate I mg/5m!: syrup. l OOml bot: 38.00 MRP

.:. ZADIFEN Tab. UniMedlUniHealth Ketotifen fumerate I mg/tablet. 50's pack: 75.00 MRP

.:. ZADIFEN Syp. UniMedlUniHealth Ketotifen fumerate I mg/5ml: syrup. 100ml bot: 35.00 MRP

.:. ZADIT Tab. Popular Ketotifen fumerate I mg/tablet. 100's pack: 150.00 IP

Leukotriene receptor antagonists MONTELUKAST26.46 MONTELUKAST : Tablet/Chewable tablet/ Oral granules Montelukast is a selective and orally active leukotriene receptor antagonist, synthesized chemically. It is used as prophylactic and also in the management of chronic asthma. It is available as- Montelukast sodium INN 4mg, Smg & IOmg oral, orodispersible & chewable tablet.

Mode of action: Montelukast is a selective & competitive leukotriene receptor antagonist, that inhibits the cysteinyl leukotriene CysLTl to occupy the receptors. The occupation of leukotriene receptors by the cysteinyl leukotriene (CysLT l ) has been correlated with the pathophysiology of asthma. Montelukast demonstrates virtually no affinity for adrenergic, hisuunine, serotonin, muscarinic or prostanoid receptors.

Ind: Montelukast is indicated for the prophylaxis and treatment of chronic asthma in adults and paediatric patients 2 years of age and older.

CII: History of hypersensitivity to any component of the product.

SIE: Montelukast is usually well-tolerated. However, there may be some side- effects, which include dizziness, headache, diarrhoea. restlessness, abdominal pain, cough, fever, asthenia, rash and upper respiratory tract infection . Precautions: Montelukast is not indicated for use in the reversal of bronchospasm in acute asthma attacks (in case of status asthmaticus) . In rare cases, patients on therapy with Montelukast may present with systemic eosinophilia, sometimes presenting with clinical features of vasculitis consistent with churg strauss syndrome- a condition which is often treated with systemic corticosteroid therapy . Physician should be alen to eosinophilia, vasculitic rash, worsening pulmonary symptoms, cardiac complications, and/or neuropathy presenting in their patients. A causal association between Montelukast and these underlying conditions has not been established.

Pregnancy & lactation: There are no adequate and well-controlled studies of Montelukast in pregnant women, so it should be used during pregnancy only if clearly needed.

It is also not known whether Montelukast is excreted in human milk, so caution should be exercised when Montelukast is given to a nursing mother.

Dosage & admin: Adults (15 years & over)10mg daily to be taken in the evening. Children, 6-14 years- Smg daily to be taken in the evening; 2-5 years- 4mg daily to be taken in the evening. Paediatric patients younger than 2 years of age- not recommended. Drug Inter: Montelukast has been

QIMP.15 (85) administered with other therapies routinely used in the prophylaxis and treatment of

chronic asthma with no appropriate increase in adverse reactions.

Cytochrome P·450 inducers: Although

phenobarbital induces hepatic metabolism, no dosage adjustment for montelukast is

recommended. It is reasonable to employ

appropriate clinical monitoring when potent cytochrome P·450 enzyme inducers, such as

phenobarbital or rifampin, are co· administered

with montelukast.

.:. AERON Tab. Healthcare Montelukast sodium INN I Omg/tablet

RESPIRATORY SYSTEM

.:. MONTENE 10 Tab. Square Montelukast sodium INN 1 0mg/tablet

treatment. As with inhaled steroids and cromones

I Omg x 1 0's pack: 200.00 MRP

zafirlukast is not indicated for use in the reversal

.:. ODMON Tab. Renata Montelukast sodium INN Smg & 1 0mg/tablet

Elderly· clinical experience with zafirlukast in

Smg x 1 0's pack: I SO.OO MRP

the elderly (over 6S years) is limited and caution

I Omg x 1 0's pack: 300.00 MRP

.:. PROVAIR Chew. Tab. UniHealth Montelukast sodium INN 4mg & Smg/tablet

(disodium cromoglycate. nedocromil sodium), of bronchospasm in acute asthma attacks.

is recommended until furher information is available.

Renal impaiment� no dosage adjustment is

4mg x 20's pack: 1 60.00 MRP

necessary in patients with mild renal impairment.

Smg x 20's pack: 200.00 MRP

Zafirlukast has not been evaluated in the

.:. PROVAIR 10 Tab. UniHealth Montelukast sodium INN I Omg/tablet

treatment of labile (brittle) or unstable asthma.

10mg x 1 0's pack: 200.00 MRP

during treatment with zafirlukast. These are

Elevations in serum transaminases can occur

I Omg x 12's pack: 240.00 IP

.:. REVERSAIR Orodispersible Tab. ACI Montelukast sodium INN 4mg & Smg/tablet

Montelukast sodium INN Smg & 1 0mgitabiet

(orodispersible)

If clinical symptoms or signs suggestive of liver

4mg x 20's pack: 1 40.00 IP

dysfunction occur (e.g nausea, vomiting, right

Smg x 20's pack: 200.00 IP

upper quadrant pain, fatigue, lethargy, flu· like

.:. ASMONT Tab. Somatec

Smg x 10's pack: 8S.00 MRP I Omg x 10's pack: ISO.OO MRP

.:. LUMONA 4 Oral Gran. SK+F Montelukast sodium INN 4mg oral granules. 4mg x IO's pack: 100.00 MRP

.:. LUMONA 5 Chew. Tab. SK+F Montelukast sodium INN Smgitablet (chewable) Smg x lO's pack: 1 00.00 MRP

.:. LUMONA 10 Tab. SK+F Montelukast sodium INN I Omg/tablet I Omg x l O's pack: 200.00 MRP

.:. M-KAST·5 Tab. Drug Inter. Montelukast sodium INN Smgitablet Smg x 30's pack: 300.00 MRP

.:. M-KAST·I0 Tab. Drug Inter. Montelukast sodium INN IOmgitablet IOmg x lO's pack: 200.00 MRP

.:. MOKAST Tab. Alco Pharma Montelukast sodium INN 4mg & I Omgitablet 4mg x 20's pack: 200.00 MRP I Omg x l O's pack: 200.00 MRP

.:. MOLUKAT 10 Tab. Chemico Montelukast sodium INN l Omg/tablet I Omg x 10's pack: 200.00 MRP

.:. MOLUS Tab. Apex Montelukast sodium INN 4mg & 1 0mg/tablet 4mg x 10's pack: 70.00 MRP

.:. REVERSAIR Tab. ACI Montelukast sodium INN I Omgitablet I Omg x 20's pack: 400.00 IP

1 0mg/tablet

patient's conditon, weighing the risk of hepatic dysfunction against the clinical benefit of

Smg x 20's pack: 200.00 MRP

zafirlukast to the patient.

10mg x 20's pack: 400.00 MRP

4mg x 20's pack: 140.00 MRP Smg x 20's pack: 200.00 MRP 1 0mg x 10's pack: 200.00 MRP

.:. MONPROX Tab. Rangs Pharma Montelukast sodium INN 1 0mg/tabiet I Omg x lO's pack: 200.00 MRP

.:. MONTAIR Tab. Incepta Montelukast sodium INN 4mg, Smg & I Omgitablet 4mg x 30's pack: 2 1 0.00 MRP Smg x 30's pack: 300.00 MRP l Omg x 20's pack: 400.00 MRP

Pregnancy & Latation: The safety of zafirlukast in human pregnancy has not been established,

ZAFIRLUKAST46.95 ZAFIRLUKAST: Tablet Zafirlukast is a leukotriene receptor antagonist, synthesized chemically. It is used as prophylactic and in the management of chronic asthma.

Mode of action: Zafirlukast is a selective, competitive antagonist of cysteinyl leukotrienes (LTC4, LTD4 & LTE4) at the cysteinyl leukotriene receptor (currently designated as CysLT I ) . Zafirlukast demonstrates virtually no affinity for adrenergic, histamine, serotonin, muscarinic or prostanoid receptors.

Ind: Zafirlukast is indicated for the prophylaxis

CII: History of hypersensitivity to the product or

.:. MONOCAST Tab. Beximco Montelukast sodium INN 4mg, Smg & IOmg/tablet

zafirlukast should be individuailsed to the

4mg x 20's pack: 1 40.00 MRP

and the management of chronic asthma in adults

1 0mg x S's pack: 1 00.00 MRP

ALT, should be measured and the patient managed accordingly. A decision to discontinue

I Omg x 10's pack: I SO.OO MRP

4mg x 5's pack: 3S.00 MRP

symptoms, enlarged liver, pruritus and jaundice), the serum transaminases, in particular serum

.:. TRILOCK Tab. Opsonin Montelukast sodium INN 4mg, Smg &

.:. MONAS Tab. Acme Montelukast sodium INN 4mg, Smg & IOmgitablet Smg x S's pack: SO.OO MRP

usually asymp·tomatic and transient but could represent early evidence of hepatotoxicity.

and children aged 12 years and over.

any of its ingredients; history of moderate or

therefore, zafirlukast should be used during pregnancy only if clearly needed. Zafirlukast is excreted in human breast milk, so, zafirlukast should not be administered to mothers who are breast-feeding.

Dosage & Admin: Adults & children over 12 years of age· 20mg twice daily; it shoul� be

taken at least 1 hour before or 2 hours after meals, or as directed by the pbysician.

Drug inter: Please see the manufacturer's literature.

.:. ZAFNIL Tab. General Zafirlukast INN 20mgitablet 10's pack: 1 20.00 MRP

.:. ZAFT Tab. Renata Zafirlukast INN 20mgitablet 10's pack: 260.00 MRP

information is available.

3. RESPIRATORY GLUCOCORTICOIDS: CORTICOSTEROIDS21

with headache or gastrointes.tinal disturbance,

Glucocorticoid steroid preparations are found

these symptoms are usually mild and do not

effective in asthma; they reduce bronchial

severe renal impairment; hepatic impairment or cirhosis. Zafirlukast is also contraindicated in children under 1 2 years of age until safety

Adverse effects: Zafirlukast may be associated

necessitate withdrawal from therapy. Hypersensitivity reactions, including urticaria

mucosal inflammation by reducing oedema & secretion of mucus into the airway. Chronic

and angioedema have been reported; rashes,

obstructive pulmonary diseases usually show

including blistering, have also been reported.

little or no response to corticosteroids. Whether

Infrequently, elevated serum transaminase levels

inhaled corticosteroids improve the lung function

have been observed, but rarely this transaminase

in COPD yet not been established; but,

profile has been consistent with drug. induced

corticosteroid inhalations are recommended for

hepatitis which resolved following cessation of

prophylactic treatment of asthma when patients

zafirlukast therapy.

Warnings & Precautions: Zafirlukast should be

are using a beta2-stimulant (agonist) 3 times a week or more or if symptoms disturb sleep more

.:. MONTENE Chew. Tab. Square

taken regularly to achieve benefit, even during

Montelukast sodium INN 4mg & Smg/tablet

symptom free periods; zafirlukast therapy should

exacerbations in the last 2 years requiring a

(chewable)

normally be continued during acute

systemic corticosteroid or a nebulised

4mg x lO's pack: 70.00 MRP

exacerbations of asthma. Zafirlukast does not allow a reduction in existing steroid

bronchodilator.2 1 Commonly used respiratory

Smg x lO's pack: 100.00 MRP

than once a week or if the patient has suffered

corticosteroids are-

Beclomethasone

QIMP-15 (86)

RESPIRATORY SYSTEM

dipropionate, Budesonide, Ciclesonide, Fluticasone propionate, Mometasone furoate, Triamcinolone etc.

propellant is safe for human, but, as it emits CFC

Ascon 250: Beclomethasone dipropionate

to the environment, it harms the planet by

2S0mcglpuff or actuation: metered dose inhaler

depleting ozone layer.

(MDI).

Mode of action: The precise mechanism of

HFA (Hydrofluoroalkane): Recently an

glucocorticoid action in asthma is unknown.

advanced HFA (Hydrofluoroalkane) technology

Glucocorticoids have been shown to inhibit

has developed as MDI propellant replacing CFC

multiple cell types (e.g mast cells, eosinophils,

propellant. HFA is an ozone-benign, environment

Ascon 100 x 200 doses unit: 200.00 MRP

basophils, lymphocytes, macrophages, and

friendly, CFC-free MDI propellant.

Ascon 250 x 200 doses unit: 250.00 MRP

Indo Bronchial asthma

Dosage & admin: See above under the text (Dosage of inhaler MOl).

neutrophils) and mediator production and


secr.etion (e.g histamine, eicosanoids,

respiratory corticosteroids.

leukotrienes, and cytokines) involved in the

Indo Prophylaxis and maintenance treatment of

Beclod-100: Beclomethasone dipropionate

asthmatic response. These anti-inflammatory

asthma specially if not fully controlled by

inhalation (DPI).

bronchodilators or cromoglycate.

Beclod-200: Beclomethasone dipropionate

actions of glucocorticoids may contribute to their efficacy in asthma.

Ind; CII: See below under the individual preparation.

SIE: Inhaled corticosteroids have considerably fewer systemic side-effects than oral corticosteroids, but high-dose inhalations are sometimes associated with some adrenal suppression and effects on bone metabolism; also hoarseness of voice and candidiasis of mouth or

SIE; Cautions: See above under the text of respiratory corticosteroids.

.:. BECLOD Inhaler (DPI) Acme

l OOmcg/capsule (Rotacap): dry powder

200mcg/capsule (Rotacap): dry powder inhalation (DPI).

Dosage & admin:

Rotacap contains single dose dry powder for oral

Recommended starting dose is 200mcg twice

Indo Bronchial asthma Dosage & admin: See above under the text

By inhalation (DPI): Adults & adolescents:

daily or lOOmcg 3-4 times daily; in more severe cases initially 600-800mcg may be given daily.

Children (5-11 yrs): SO-lOOmcg 2-4 times daily.

inhalation, specially to be used with 'Rotahaler'.

(Dosage of inhaler DPI).

Beclod 100 x 30 doses (rotacap): 45.00 MRP Beclod 200 x 30 doses (rotacap): 63.60 MRP

rash.

Dry powder inhaler (DPI) is administered by a device (such as Cozyhaler, Cyclohaler,

Beclomin 100: Beclomethasone dipropionate

may need to reinstate systemic therapy during

Rinsing the mouth after inhalation is advised.

(MDI).

periods of stress or when airways obstruction or

By. inhalation (MDI): Adults & adolescents:

Beclomin 250: Beclome30mIlmin). Hyponatraemia (specially in patients on sodium-lowering comedication). Patients with pre-existing cardiac insufficiency and secondary heart failure. Hepatitis. Abrupt discontinuation of treatment. Road and machinery users. Alcohol.

Dosage & admin: Adults: 600-2400mglday.

Children: 2 years of age and above 8-46mglkgl

day. Administration in two divided doses. Drug inter: Felodipine, oral contraceptives.

Antiepileptics (e.g carbamazepine, phenobarbital, phenytoin).

Note: For further information consult full prescribing information.

.:. OXAZEP Tab. Incepta Oxcarbazepine INN 300mg

& 600mg!tablet (f.c).

300mg x 30's pack: 540.00 MRP

with valproate 100-200mg daily in 1-2 divided

600mg x 20's pack: 600.00 MRP

Adjunctive therapy without valproate. initially

Oxcarbazepine INN 300mg/5ml: suspension.

doses; Elderly not be recommended.

50mg daily for 14 days then 50mg twice daily

.:. OXAZEP Susp. Incepta 100mi bot: 350.00 MRP

QIMP-15 (122)

CENTRAL NERVOUS SYSTEM

.:. OXETOL Tab_ Sun Pharma

60mg x 100's pack: 1 14.00 MRP

PREGABALIN: Capsule

Oxcarbazepine 150mg & 300mgltablet (tc),

.:. PHENOBARBITONE Tab. Seema

Pregabalin is used as a second-line drug for the

150mg x SO's pack: 3S0.00 MRP

Phenobarbital BP 30mg/tablet

treatment of partial (or focal) seizures with or

300mg x SO's pack: 600.00 MRP

30mg x 100's pack: 60.00 MRP

without secondary generalisation, It is also useful

.:. TRILEPTAL Tab_ Novartis

.:. PHENOSON Tab. Jayson

in the treatment of neuropathic pain &

Oxcarbazepine 300mg and 600mg/tablet (f .c).

Phenobarbital BP 30mg & 60mg/tablet

generalised anxiety disorder. It is available as

300mg x SO's pack: 1 250.00 MRP 600mg x SO's pack: 22S0.00 MRP

30mg x 100's pack: 78.00 MRP 60mg x 1000's pot: 1 90.00 MRP

Ind: Treatment of partial (or focal) seizures with

PHENOBARBITONE2 1.26.33

PHENYTOIN2 1 ,33

central neuropathic pain, generalised anxiety

PHENOBARBITONE:Tablet/Injection

pregabalin INN 7Smg, 100mg & 150mg capsule, '

or without secondary generalisation, peripheral &

Phenobarbitone (Phenobarbital), a barbiturate,

PHENYTOIN: Tablet/Capsule/Syrup Ind: Grandmal & temporal lobe epilepsy,

nonselective, central nervous system depressant

trigeminal neuralgia, migraine.

which is primarily used as a sedative hypnotic &

CII: Avoid i. v injection in patients with

also as an anticonvulsant in subhypnotic doses.

bradycardia or heart block.

Ind: It is indicated for the following conditions:

SIE: Nausea, vomiting, mental confusion,

I. As sedatives. 2. Hypnotics for the short-term

dizziness, headache, tremor, transient

treatment of insomnia. 3. Long-term (oral)

nervousness, insomnia occur commonly; rarely

anticonvulsants for the treatment of generalized

dyskinesias, peripheral neuropathy; ataxia,

tonic-clonic and cortical local seizures. And,

slurred speech, nystagmus and blurred vision are

parenteral preparations are used in the emergency

signs of overdosage; rashes (discontinue, if mild

control of certain acute convulsive episodes (those

re-introduce cautiously but discontinue

associated with status epilepticus, eclampsia,

immediately if recurrence), coarse facies, acne

meningitis, tetanus, & toxic reactions to strychnine

and hirsutism, fever and hepatitis; lupus

or local anesthetics). 4. Pre-anesthetics.

erythematosus, erythema multiforme (Stevens

CII: Patients with a history of alcohol or drug

Johnson syndrome), . toxic epidermal necrolysis,

abuse, acute intermittent porphyria.

polyarteritis nodosa; lymphadenopathy; gingival ' hypertrophy and tenderness; rarely

SIE: Drowsiness, lethargy, ataxia and allergic skin reacitons; paradoxical excitement,

haematological effects, including megaloblastic

restlessness and confusion in the elderly &

anaemia may be treated with folic acid),

hyperkinesia in children, megaloblastic anaemia.

leucopenia, thrombocytopenia, agranulocytosis,

Cautions: Liver disorder, renal impairment,

and aplastic anaemia; plasma calcium may be

severe pulmonary insufficiency, the elderly &

lowered (rickets and osteomalacia).

debilited, pregnancy, lactation. Tolerence and

Cautions: Liver dysfunction, pregnancy (reduce

dependence may develop.

dose), lactation. Withdraw drug slowly.

Dosage & admin: By mouth: Adults: Daytime sedative, 30mg to 120mg daily in 2 to 3 divided doses; At night; 60mg to 320mg_ Children: As anticonvulsant 1-6mglkg daily (febrile convulsion, 3-4mglkg daily); Preoperative, 1mg to 3mglkg_ By i.m or i.v injection: Adults: SO-200mg as a single dose, repeat after 6 hours if necessary, maximum 600mg daily. Children: By i.m or i.v injection, upto 1 year 30- 60mg; l-S years 90mg; 6-12 years 120mg, or 3-Smg /kg intramuscularly. (For i.v. administration, dilute injection 1 in 10 with water before administration).

Concurrent admin. of coumarin anticoagulants,

.:. BARBIT Tab. Incepta Phenobarbital BP 30mg & 60mgltablet 30mg x 100's pack: 78.00 MRP 60mg x l oo's pack: 1 14.00 MRP

isoniazid, chloramphenicol, sulthiame arid oral contraceptives.

Dosage & admin: Adult: 200mg daily increased to 400mg daily (max. 600mglday) in divided doses (2-4 times) according to patients response or 3-4 mglkg daily in divided doses. Child: Upto 1 year 2S mg, l-S years 2S- SO mg increasing to 7Smg, 6-12 years SO-100mg increasing to lS0mg. All twice daily, or S Smglkg daily in divided doses. .:. DIPHEDAN Tab. Ambee Phenytoin 100mg/tablet. 100's pack: 10 1 .00 MRP

.:. DIPHEDAN Susp. Ambee Phenytoin 60mg/Sml: suspension. 100m! bot: 30.34 MRP

.:. BARBIT Inj. Incepta Phenobarbital sodium BP 200mg/ml; 1m!

PlRACETAM

ampoule: injection. lml amp: x 5's pack: 80.00 MRP

.:. BERDINAL Tab. Gaco Phenobarbitone BP SOmgltablet 50mg x 100's pack: 23.8S MRP

.:. BERDINAL Inj. Gaco Phenobarbital sodium BP 200mglml; 1m! ampoule: injection. Iml amp: x I 's pack: S . 2 1 MRP

.:. PHENO Tab. Delta Phenobarbital BP I Smg, 30mg & 60mg/tablet 15mg x 100's pack: 57.00 MRP 30mg x 1 00's pack: 77 .00 MRP

Piracetam is indicated & may be used in epileptic patients who are suffering from myoclonus of cortical origin. Piracetam is mainly a 'nootrope' psychotropic agent, which acts directly on the brain to improve the efficacy of the telencephalon in both normal subjects and those suffe,ring from some functional deficits. This drug has been discussed in this chapter under the 'antiparkinson's drugs'.

PREGABALIN21 , 26

disorder & post herpetic neuralgia.

CII: Known hypersensitivity to pregabalin, SIE: Pregabalin is well tolerated but a few side effects like dizziness, somnolence and blurred vision may occur.

Precautions: Abrupt or rapid discontinuation of pregabalin may produce some symptoms including insomnia, nausea, headache and diarrhoea, So, pregabalin should be tapered gradually over a minimum of I week rather than discontinuing abruptly.

Pregnancy & lactation: Pregabalin should be used during pregnancy

& lactation only if the

potential benefit justifies the potential risk to the fetus & infants,

Dosage & admin: Neuropathic pain: Initially lS0mg daily in 2 divided doses, increased if necessary after 3-7 days to 300mg daily in 2 divided doses, increased further if necessary after 7 days to maximum 600mg daily in 2 divided doses. Epilepsy: Initially lS0mg daily in 2 divided doses, increased if necessary after 7 days to 300mg in 2 divided doses, increased further if necessary after 7 days to maximum 600mg daily in 2 divided doses. Post herpetic neuralgia: The recommended dose of pregabalin is 75 to lS0mg twice daily. ' Dosing should begin at 7Smg two times a day and may be increased to 300mg daily within 1 week based on efficacy and tolerability. Children: The safety & efficacy of pregabalin in pediatric patients have not been established. .:. GABAROL Cap. ACI Pregabalin 7Smg, 100mg & 150mglcap�ule. 75mg x 30's pack: 480.00 IP 100mg x 20's pack: 440.00 l S0mg x 20's pack: 600.00

IP IP

.:. PREGABA Cap. Opsonin Pregabalin INN 7Smg & ISOmg/capsule, 7Smg x 30's pack: 480,00 MRP I SOmg x 30's pack: 900.00 MRP

.:. PREGABEN Cap. Incepta Pregabalin INN 7Smg & 1 50mg/capsule. 7Smg x 30's pack: 480.00 MRP l S 0mg x 20's pack: 600.00 MRP

SODIUM VALPROATENALPROIC ACID21,63 SODIUM VALPROATE NALPROIC ACID: Tablet/Injection Ind: All forms of epilepsy Cautions: Monitor liver function before therapy and during first 6 months especially in patients most at risk, ensure no undue potential for bleeding before starting and before major s.urgery; renal impairment; pregnancy; breast feeding; systemic lupus erythematosus; false-

QIMP-15 (123)

positive urine tests for ketones; avoid sudden withdrawal.

Liver toxicity: Liver dysfunction (including fatal hepatic failure) has occurred in association with

valproate (specially in children under 3 years of

age and those with metabolic or degenerative

disorders, organic brain disease or severe seizure

disorders associated with mental retardation)

usually in the first 6 months of therapy and

usually involving multiple antiepileptic therapy (monotherapy preferred). Raised liver enzymes are not uncommon during valproate treatment

and are usually transient but patients should be reassessed clinically and liver function (including

prothrombin time) monitored until return to normal-an abnormally prolonged prothrombin time (particularly in association with other

relevant abnor-malities) requires discontinuation of treatment: Any concomitant use of salicylates should be stopped.

CII: Active liver disease. family history of severe

hepatic dysfunction, porphyria

SIE: Gastric irritation, nausea, ataxia and tremor;

hyperammonaemia, increased appetite and weight

gain; transient hair loss (regrowth may be curly).

oedema, thrombocytopenia. and inhibition of

platelet aggregation; impaired hepatic function leading rarely to fatal hepatic failure withdraw

treatment immediately if vomiting, anorexia, jaundice, drowsiness, or loss of seizure control

occurs); rashes; sedation reported (rarely lethargy and confusion associated with too high an initial

dose) and also increased alertness (occasionally aggression, hyperactivity and behavioral disturbances); rarely pancreatitis (measure

plasma amylase in acute abdominal pain).

leucopenia, pancytopenia, red cell hypoplasia. fibrinogen reduction; irregular periods.

amenorrhoea, gynaecomastia, hearing loss,

Fanconi's syndrome, dementia, toxic ·epidermal necrolysis, Stevens-Johnson syndrome. and vasculitis also reported.

Dosage & admin: By mouth- adult, initially, 600mg daily given in 2 divided doses, preferably after food, increasing by 200mglday at 3-day intervals to a maximum of 2.5gm daily in divided doses, usual maintenance 12gm daily (20-30 mglkg daily): Child- up to 20 kg, initially 20mglkg daily in divided doses, may be increased provided plasma concentrations monitored, (also monitor clinical chemistry and haematological parameters): over 20kg initially 400mg daily in divided doses increased until control (usually in range of 20-30mglkg daily): max_ 35mglkg daily. .:. CONVULES CR Tab. Opsonin

Convules CR 200 tablet: contains sodium

For dosage- see under the text (above).

200mg (CR tablet) x SO's pack: 200.00 MRP


.:. VAPO Tab. White Horse

Sodium valproate SP 200mg/tablet.

300mg (CR tablet) x 30's pack: 1 80.00 MRP

30's pack: 7S.OO MRP

·:· ·ENCORATE Tab. Sun Pharma .

TOPlRAMATE I06

SOOmg (CR tablet) x 20's pack: 200.00 MRP Sodium valproate 200mg/tablet (enteric coated). SO's pack: 1 42.S0 MRP

TOPIRAMATE: Tablet

.:. ENCORATE Chrono 300 Tab. Sun Pharma

Sodium valproate + valproic acid 300mg/tablet.


Topiramate- 2Smg & SOmg/tablet.

Ind: Topiramate is indicated as monotherapy or adjunctive therapy for adults and children (2

.:. ENCORATE Chrono 500 Tab. Sun Pharma

Sodium valproate + valproic acid SOOmgltablet. 30's pack: 300.00 MRP

years and above) with partial onset seizures or

generalized tonic-clonic seizures in epilepsy. It is also indicated as adjunctive therapy for the

.:. EPILIM 200 Tab. Sanofi-aventis

Sodium valproate 1 33.2mg + valproic acid S8mg/tablet.

treatment of seizures associated with Lennox

Gastaut syndrome.

CII: History of hypersensitivity to any


component of this product.


Sodium valproate 1 99.8mg + valproic acid

Adverse effects: Monotherapy: In a double-blind clinical trial.


greater than or equal to 10% in either treatment

87mg/tablet.

adverse events that occurred at a frequency


group, are- paraesthesia, headache, dizziness.

Sodium valprQate 333mg + valproic acid

fatigue, somnolence, weight decrease, nausea,

30's pack: 300.00 MRP

monotherapy were consistent with, but generally

l 4Smg/tablet.

and diarrhea. These adverse e,vents with

.:. EPILIM Syp. Sanofi-aventis

Sodium valproate 200mglSml: syrup 1 00ml bot: 80.00 MRP

.:. PROVAL Tab. General

Sodium valproate 200mgltablet.

less frequent than the adverse events with

adjunctive therapy.

Adjunctive therapy: Adults: In double-blind trials, adverse events that occurred with a

frequency greater than or equal to S% and with a


higher incidence in the topiramate-treated adult

.:. PROVAL Syp. General

patients than in the placebo group. These include

syrup

fatigue. speech disorders/related speech

Valproic acid as sodium valproate 2oomg/Sml: 1 00mi bot: 7S.00 MRP

problems,· psychomotor slowing. abnormal

.:. VALAPI Tab. Medimet

Sodium valproate 200mg/tablet.

SO's pack: 3 1 0.00 MRP

.:. VALEX Tab. Incepta

somnolence, dizziness, nervousne'ss, ataxia,

vision, difficulty with memory (not otherwise

specified), confusion, paraesthesia, diplopia.

anorexia, nystagmus, nausea, weight decrease, .

Sodium valproate 200mg/tablet. SO's pack: 1 2S.00 MRP

.:. VALEX CR Tab. Incepta

Valex CR 200 tablet: contains sodium valproate BP 1 3 3.2mg & valproic acid BP SSmg equivalent

to sodium valproate 200mg.

Valex CR 300 tablet: contains sodium valproate BP 199.8mg & valproic acid SP 87mg equivalent

to sodium valproate 300mg.

Valex CR SOO tablet: contains sodium valproate BP 333mg & valproic acid SP l 4Smg equivalent

to sodium valproate SOOmg. (All are controlled release tablet)·

Dosage' & admin: Valex CR is a prolonged release formulation of sodium valproate, thus Valex CR may be given once or twice daily. For dosage- see under the text (above). 200mg (CR tablet) x SO's pack: 200.00 MRP

300mg (CR tablet) x SO's pack: 300.00 MRP '

language problems. difficulty with

concentration/attention, depression, abdominal

pain, asthenia, and mood problems. Adverse events that occurred more frequently with

adjunctive therapy than with monotherapy included somnolence. dizziness. difficulty with memory. psychomotor slowing. confusion.

nervousness, ataxia, vision abnormal, diplopia, speech disorders and related speech problems,

and nystagmus.

Pediatric patients: In double-blind clinical trials, adverse events that occurred at a frequency

greater than or equal to S% and with a higher incidence in the topiramate-treated pediatric

patients than in the placebo group. These include somnolence, anorexia, fatigue, nervousness,

personality disorder, difficulty with

concentration! attention, aggressive reaction,

weight decrease, abnormal gait. mood problems,

ataxia, salivation, nausea, difficulty with memory

valproate BP 1 3 3.2mg & valproic acid B P'S8mg

SOOmg (CR tablet) x 28's pack: 280.00 MRP

(not otherwise specified), hyperkinesia, dizziness,

Valproic acid as sodium valproate 200mglSml;

.:. VALEX Syp. Incepta

speech disorders/related speech problems. and

Convules CR 300 tablet: contains sodium

valproate B P 199.8mg & valproic acid BP 87mg

syrup

equivalent to sodium valproate 300mg.

1 00ml bot: 7S.00 MRP

Warnings & precautions: Antiepileptic drugs.

Convules CR SOO tablet: contains sodium

.:. VALPRO Tab. Somatec

equivalent to sodium valproate 200mg.

paraesthesia.

including topiramate. should be withdrawn

gradually to minimize the potential of increased

Sodium valproate 200mgltablet.

SO's pack: 12S .00 MRP

seizure frequency. In clinical trials, dosages were

equivalent to sodium valproate SOOmg. (All are controlled release tablet)

.:. VALPRO Syp. Somatec

some patients withdrawal was accelerated

valproate BP 333mg & valproic acid SP 14Smg

Dosage & admin: Convules CR is a prolonged release formulation of sodium valproate, thus Convules CR may be given once or twice daily.

Valproic acid as sodium valproate 200mglSml:

decreased by 1 00mg/day at weekly intervals. In

without complications.

syrup

The major route of elimination of unchanged

1 00ml bot: 7S.00 MRP

topiramate and its metabolites is the kidney.

QIMP.IS (124)


Renal elimination is dependent on renal function

When enzyme-inducing drugs are withdrawn,

generally well tolerated.

and is independent for age. Patients with

topiramate levels will increase. A decrease in

Drug inter: Effects oftopiramate on other

moderate or severe renal impairment may take 1 0

topiramate dosage may be required if

t o 1 5 days to reach steady· state plasma

clinically indicated.

concentrations as compared to 4 to 8 days in

Adults: Titration should begin at 2Smg nightly

patients with normal renal function.

for 1 week. The dosage should then be

In all patients, the titration schedule should be

increased at I· or 2-week intervals by

guided by clinical outcome (i.e seizure control,

increments of 2Smg or SOmglday, administered

avoidance of side·effects) with the knowledge

in two divided doses.

H the patient is unable to

that subjects with known renal impairment may

tolerate the titration regimeu, smaller

require a longer time to reach steady· state at

increments or longer intervals between

each dose.

increments can be considered. Dose & titration

Some patients, specially those with a history of

rate should be guided by clinical outcome.

prior stone formation, or family history of

The recommended iuitial target dose range for

nephrolithiasis or hypercalci·uria, are at increased

topiramate monotherapy in adults is l00mg to

risk for renal stone formation with topiramate

200mglday and the maximum recommended

therapy. Adequate hydration is recommended to

daily dose is SOOmg. Some patients with

reduce this risk. In addition, patients taking other medica-tions

refractory forms of epilepsy have .tolerated topiramate monotherapy at doses of

associated with nephrolithiasis or on a ketogenic

l000mglday. These dosing recommendations

diet may be at increased risk. Therefore, while

can be applied to all adults including the

using topiramate, patient should avoid ketogenic

elderly in the absence of underlying renal

diet.

disease.

In hepatic impaired patients, topiramate should

Children: Treatment of children

be administered with caution as the clearnce of topiramate may be decreased. A dietary supplement or increased food intake may be considered if the patient is losing weight while on this medication. Effects on ability to drive and use machines: As with all AEDs, patient taking topiramate is potentially in danger while driving a vehicle or operating machinery, particulary until such time as the individual patient's experience

with the

drug is established.

Pregnancy & lactation: There are no studies using topiramate in pregnant women. But, as with other AEDs, topiramate was found teratogenic in mice, rats and rabbits. Therefore, topiramate should only be used during pregnancy, if the potential benefit outweighs the potential risk to the fetus. In lactating women, it is not known whether topiramate is excreted in breast milk. But, as topiramate is excreted in the milk of lactating rats, and as many drugs are excreted in human milk, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. In marketing experience, cases of hypospadias have been reported in male infants exposed in utero to topiramate, with or without other anticonvulsants; however, a causal relationship with topiramate has not been established.

(2 years and above) should begin at Img to 3mglkg nightly for the first week. The dosage should then be increased at 1- or 2-week intervals by increments of Img to 3mglkglday, administered in two divided doses. If the child is unable to tolerate the titration regimen, smaller increments or longer intervals between dose increments can be considered. Dose and titration rate should be guided by dinical outcome.

Adjunctive therepy: Adults: Titration should begin at 2Smg nightly for 1 week. Subsequently, at weekly or biweekly intervals, the dose should be increased by 2Smglday and given in two divided doses. Dose titration should be guided by clinical outcome. Some patients may achieve efficacy with once-a-day dosing. The usual total daily dose of topiramate as adjunctive therapy is 200mg to 400mglday in two divided doses. Individual patients bave received dosages as high as 1600mglday. Because topiramate is removed from plasma by hemodialysis, a supplemental dose of topiramate equal to approximately one·half the daily dose should be administered in divided doses at the beginning and completion of the hemodialysis procedure. This supplemental dose may vary based on the characteristics of the dialysis equipment used.

in both adults and children, it is

These dosing recommendations can be applied to all adults, including the elderly, in the

recommended that therapy should be

absence of underlying renal disease.

Dosage & admin: For optimal seizure control

initiated at a low dose followed by titration to

Children: The recommended total daily dose

an effective dose. Because of the bitter taste,

of topiramate as adjunctive therapy for

tablets should not be broken.

antiepi/eptic drugs: The

addition of topiramate to

other AEDs (phenytoin, carbamazepine, valproic acid. primidone, phenobarbitone) has no effect on their steady·state plasma concentrations, except in the occasiounal patient, where the addition of topiramate to phenytoin may result in an increase in plsma concentrations of phenytoin. Consequently, any patient on phenytoin showing clinical signs or symptoms of toxicity should have phenytoin levels monitored.

Effects of other antiepi/eptic drugs on topiramate: Phenytoin and carbamazepine decrease the plasma concentration of topiramate. The addition or withdrawal of phenytoin or cabamazepine to topiramate therapy may require an adjustment in dosage of the latter. This should be done by titrating to clinical effect. The addition or withdrawal of valproic acid does not produce clinically significant changes in plasma concentrations of topiramate and, therefore, does not warrant dose adjustment of topiramate.

Other drug interactions:

When topiramate is

added or withdrawn in patients on digoxin therapy, careful attention should be given to the routine monitoring of serum digoxin levels. Topiramate is not recommended to use concomitantly with alcohol or other CNS depressant drugs. Patients taking topiramate concomitantly with oral contraceptives should be asked to report any change in their bleeding patterns.

.:. TOPAMAX Tab. Janssen CilaglUniHeaIth Topiramate 25mgltablet. 25mg x 60's pack: 1 7 80.80 MRP

.:. TOPIRVA Tab. Incepta Topiramate INN 25mg

& 50mgltablet.

25mg x 50's pack: 1 50.00 MRP 50mg x 50's pack: 250.00 MRP

8. DRUGS USED IN PARKINSONISM & RELATED DISORDERS2 1 The drugs used in parkinsonism

& related

disorders are classified as:

1

Dopaminergic drugs used in parkinsonism

2

Antimuscarinic drugs (anticholinergic drugs) used in parkinsonism

7. Drugs used in essential tremor, chorea, tics & related disorders

Dopaminergic drugs21

seizures in children is approximately Smg to

Monotherapy: When concomitant anti

9mglkglday in 2 divided doses. Titration

epileptic drugs (AEDs) are withdrawn to

should begin at lSmg to 2Smg (or less based

achieve monotherapy with topiramate,

on a range of Img to 3mglkglday) nightly for

consideration should be given to the effects of

the first week. To achieve optimal clinical

this drug, that may have on seizure control.

response, the dosage should then be increased

Unless safety concern, an abrupt withdrawal

at I· or 2-week intervals by increments of

of the concomitant AED is not advised, rather

Img to 3mglkglday (administered in 2 divided

a gradual discontinuation at the rate of

doses). Dose titration should be guided by

approximately one third of the concomitant

clinical outcome. Daily doses up to

AED dose every 2 weeks is recommended.

30mglkglday have been studied and were

Dopaminergic drugs include: I. Dopamine precursor: Levodopa and some combined preparations, viz: Co-beneMopa,

Co-careMopa. 2. Dopamine receptor agonists, viz:

Amantmiine, Apomorphine, Bromocriptine, Cabergoline, Enfacapone, Lysuride, Pergoiide, Pramipexoie, Rasagiline, Ropiniroie, Rotigotine, Seiegiline, Toicapone.

QIMP-15 (125)

small increments to maximum 8 tablets daily.

LEVODOPA21,33

Usual maintenance dose is 212 tablets 3 or 4 times daily after food_ As the patient ages, the

LEVODOPA: Tabletl Capsule,

maintenance dose may need to be reduced.

Levodopa, the amino acid precursor of

Child: Not recommended.

dopamine, acts mainly by replenishing depleted

Dosage of Co-careldopa 275 (Ievodopa 250mg

striatal dopamine, It improves bradykinesia and

+ carbidopa 25mg)/tablet:

rigidity more 1 .5mgldl (males), > 1 .4mgldl (females), or abnormal creatinine

clearance] which may also result from conditions such as cardiovascular collapse (shock), acute

phenytoin, nicotinic acid, sympathomimetics,

calcium channel blockers and isoniazid tend to

produce hyperglycemia and may lead to loss of glycemic control.

myocardial infarction, and septicemia; ii. Known

hypersensitivity to pioglitazone, metformin or any other component of the combination; iii.

Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.

.:. GLYMIN Phis Tab. Healthcare

Diabetic ketoacidosis should be treated with

500mgltablet (film-coated)

metformin should be temoprarily discontinued in

.:. MEFOGLIP 250 Tab. Incepta

intravascular administration of iodinated contrast

2S0mgltablet (film-coated)

result in acute alteration of renal function.

.:. MEFOGLIP 500 Tab. Incepta Glipizide 2.5mg + metformin hydrochloride

upper respiratory tract infection, diarrhea,

30's pack: 84.00 IP

similar between groups treated with pioglitazone

Glipizide 2.5mg + metformin hydrochloride 30's pack: 97.50 MRP

Glipizide 2.Smg + metformin hydrochloride 50's pack: 95.00 IP


insulin. Combination of pioglitazone and

patients undergoing radiologic studies involving

materials, becaues use of such products may

SIE: The most common adverse events were

combined edema/peripheral edema and headache, respectively. Most clinical adverse events were

.:. MEFOGLIP DS Thb. Incepta

in combination with metformin and those treated


Precautions: General: Pioglitazone

.:. METAZID Tab. Popular

only in the presence of insulin. Therefore,

Glipizide Smg + metformin hydrochloride

with pioglitazone monotherapy.

30's pack: 1 1 1 .00 MRP

hydrochloride exerts its antihyperglycemic effect

Glipizide 2.5mg + metformin hydrochloride

combination of pioglitazone and metformin

30's pack: 75.00 IP

diabetes or for the treatment of diabetic


should not be used in patients with type I

.:. METGLIP Thb. Pacific

ketoacidosis. Metformin is known to be


of metformin accumulation and lactic acidosis

.:. METGLIP Plus Tab. Pacific

function. Thus, patients with serum creatinine


age should not receive combination of

.:. METGLIP DS Tab. Pacific

Cardiovascular: Therapy with pioglitazone,

500mgitablet (film-coated)

reported in patients both with and without

Glipizide 2.5mg + metformin hydrochloride 50's pack: 95.00 MRP

'Glipizide 2.5mg + metformin hydrochloride 30's pack: 89.40 MRP

Glipizide 5mg + metformin hydrochloride 30's pack: 120.00 MRP

PIOGLITAZONE

+

substantially excreted by the kidney and the risk

increases with the degree of impairment of renal levels above the upper limit of normal for their pioglitazone and metformin.

cases of congestive heart failure has been

previously known heart disease. Combination of pioglitazone and metformin should be used with

METFORMIN42

caution in patients with edema. Since

thiazolidinediones, including pioglitazone can

cause fluid retention, which can exacerbate or

PIOGLITAZONE + METFORMIN: Tablet

lead to congestive heart failure. So, combination

This is a combination of two antihyperglycemic

of pioglitazone and metformin should be used

pioglitazone is a member of the thiazolidinedione

Hepatic effects: Serum ALT (alanine

The combination preparations of pioglitazone and

prior to the initiation of therapy with combination

agents, in which metformin is a biguanide and

group of other antidiabetics.

metformin are available as tablet in two fixed

with caution in patients at risk for heart failure. aminotransferase) levels should be evaluated

of pioglitazone and metformin in all patients and

presentations, viz: i. Pioglitazone ISmg +

periodically thereafter do the clinical judgment of

Pioglitazone l 5mg + Metformin hydrochloride

tests should also be done for patients if

Metformin hydrochloride BP 500mg; ii.

the health care professional. Other liver function

BP 8S0mg.

symptoms suggestive of hepatic dysfunction, e.g

Mode of action: See above under the text of pioglitazone and metformin given separately.

Ind: This combination is indicated as an adjunct

to diet and exercise to improve glycemic control in patients with type 2 diabetes- i. who are already treated with a combination of

pioglitazone and metformin as separate tablets, or ii. whose diabetes is not adequately controlled

with metformin alone, or iii. for those patients

who have initially responded to pioglitazone

alone and require additional glycemic control.

CII: Combination of pioglitazone and metformin

is contraindicated in patients with: i. Renal

nausea, vomiting, abdominal pain, fatigue,

anorexia, or dark urine. If jaundice is observed, drug therapy should be discontinued.

Pregnancy & lactation: This combination is not

recommended during pregnancy & lactation, so, a suitable treatment schedule should be prescribed with insulin.

Dosage & admin: Selecting the starting dose of this combination should be based on the patient's current regimen of pioglitazone andlor metformin. This combination should be given in divided daily doses with.meals to reduce the gastrointestinal side effects

associated with metformin. Starting dose for patients inadequately controlled on metformin monotherapy: Based on the usual starting dose of pioglitazone (1530mg daily), this combination may be initiated at either the 15mgl500mg or 15mgl850mg tablet once or twice daily, and gradually titrated after assessing adequacy of therapeutic response. Starting doseforpatients who initially responded to pioglitazone monotherapy and require additional glycemic control: Based on the usual starting doses of metformin (500mg twice daily or 850mg daily), this combination may be initiated at either the 15mgl500mg tablet twice daily or 15mgl850mg tablet once daily, and gradually titrated after assessing adequacy of therapeutic response. Starting dose for patients switchingfrom combination therapy ofpioglitazone plus metformin as separate tablets: Either combination 15mgl500mg or combination 15mgl850mg based on the dosage of pioglitazone and metformin already being taken. Maximum recommended dose: The maximum recommended dose for pioglitazone is 45mg daily. The maximum recommended daily dose for metformin is 2550mg in adults. .:. ACTOMEG 500 Tab. UniMed Pharma

Pioglitazone 15mg + metformin hydrochloride 500mgltablet (film-coated) 20's pack: 1 80.00 MRP

.:. ACTOMEG 850 Tab. UniMed Pharma

Pioglitazone ISmg + metformin hydrochloride 850mgltablet (film-coated) 20's pack: 200.00 MRP

.:. COMPIMET 500 Tab. Incepta

Pioglitazone 15mg + metformin hydrochloride

500mgltablet (film-coated) 30's pack: 270.00 MRP

.:. COMPIMET 850 Tab. Incepta

Pioglitazone 15mg + metformin hydrochloride 8S0mgitablet (film-coated) 30's pack: 300.00 MRP

.:. GLITAMIN 500 Tab. White Horse

Pioglitazone 15mg + metformin hydrochloride 500mgitablet (film-coated) 30's pack: 270.00 MRP

.:. GLITAMIN 850 Tab. White Horse

Pioglitazone ISmg + metformin hydrochloride 850mgitablet (film-coated) ; 30 s pack: 300.00 MRP

.:. METOPA Tab. SK+F

Pioglitazone 15mg + metformin hydrochloride 500mgltablet (film-coated) 30's pack: 270.00 MRP

.:. PIOL-M 500 Tab. Opsonin Pioglitazone ISmg + metformin hydrochloride 500mgltablet (film-coated) 20's pack: 1 80.00 MRP

.:. PIOL-M 850 Tab. Opsonin

Pioglitazone 15mg + metformin hydrochloride 8S0mgitablet (film-coated)

20's pack: 200.00 MRP

.:. PIOMET 500 Thb. Silva

Pioglitazone 15mg + metformin hydrochloride 500mgltablet (film-coated) 30's pack: 1 80.00 MRP

QIMP·15 (143)

.:. PIOMET 850 Tab. Silva

Pioglitazone l5mg + metformin hydrochloride 850mg/tablet (film·coated)

30's pack: 2 10.00 MRP

.:. PI9MIN 500 Tab. Pacific

Pieglitazone 15mg + metformin hydrochloride 500mgitablet (film'coated) 30's pack: 300.00 MRP

.:. PIOMIN 850 Tab. Pacific

Pioglitazone 15mg + metformin hydrochloride 850mgitablet (film·coated) 30's pack: 345.00 MRP

.:. POLITOR 500 Tab. ACI

Pioglitazone 15mg + metformin hydrochloride 500mgitablet (film·coated)

30's pack: 270.00 IP

:. POLITOR 850 Tab. ACI

•

Pioglitazone 15mg + metformin hydrochloride 850mgitablet (film·coated) 30's pack: 300.00 IP

.:. REZULIN 500 Tab. Square Pioglitazone 15mg + metformin hydrochloride

500mgitablet (film·coated) 30's pack: 270.00 MRP

.:. REZULIN 850 Tab. Square

Pioglitazone l5mg + metformin hydrochloride 850mgltablet (film·coated) 30's pack: 300.00 MRP

ROSIGLITAZONE

+

METFORMIN42

ROSIGLITAZONE + METFORMIN: Tablet This is a combination of two antihyperglycemic

agents, in which metformin is a biguanide and

rosiglitazone is a member of the

thiazolidinedione group of other antidiabetics.

The combination preparations of rosiglitazone

and metformin are available as tablet in two fixed

presen(»tions, viz: i. Rosiglitazone Img + Metformin hydrochloride BP 500mg; ii.

Rosiglitazone 2mg + Metformin hydrochloride BP 500mg.


rosiglitazone and metformin given separately.

Ind: This combination is indicated as an adjunct

This combined preparation is generally given in divided doses with meals, with gradual dose escalation. This reduces gastrointestinal side effects (largely due to metformin) and permits determination of the minimum effective dose for the individual patient. Combination therapy in drug·nalve patients: The recommended starting dose of this combination is 2mgi500mg administered once or twice daily. For patients with HbA lc>l1 % or FPG>270mgidl, a starting dose of 2mgl500mg twice daily may be considered. The dose of this combination may be increased in increments of 2mgl500mg per day to a maximum of 8mgl2,OOOmg per day given in divided doses if patients are not adequately controlled after 4 weeks. Combination therapy in patients inadequately controlled with rosiglitazone or metformin monotherapy: The selection of the dose of this combination in patients treated with rosiglitazone and/or metformin therapy should be based on the patient's current doses of rosiglitazone and/or metformin. After an increase in metformin dosage, dose titration is recommended if patients are not adequately controlled after 1 to 2 weeks. After an increase in rosiglitazone dosage, dose titration is recommended if patients are not adequately controlled after 8 to 12 weeks. For patients inadequately controlled on metformin monotherapy, the usual starting dose of this combination is 4mg rosiglitazone (total daily dose) plus the dose of metformin already being taken. For patients inadequately controlled on rosiglitazone monotherapy, the usual starting dose of this combination is l000mg metformin (total daily dose) plus the dose of rosiglitazone already being taken. When switching from combination therapy of rosiglitazone plus metformin as separate tablets, the usual starting dose of this combination is the dose of rosiglitazone & metformin already being taken.

Rosiglitazone 2mg + metformin hydrochloride

500mg/tablet (film·coated) 30's pack: 1 80.00 MRP

.:. ROSIMET-l Tab. Delta

Rosiglitazone I mg + metformin hydrochloride

500mgltablet (film·coated) 30's pack: 120.01 MRP

.:. ROSIMET-2 Tab. Delta


500mgltablet (film-coated) 30's pack: 1 80.00 MRP

.:. ROSIMIN 1 Tab. White Horse + metformin hydrochloride

Rosiglitazone Img

500mgitablet (film-coated) 30's pack: 120.00 MRP

.:. ROSIMIN 2 Tab. White Horse


500mgltablet (film-coated) 50's pack: 350.00 MRP

.:. ROTAMIN 2 Tab. ACI

Rosiglitazone 2mg + metformin hydrochloride 500mg/tablet (film-coated) 30's pack: 1 80.00 IP

.:. ROTAMIN 2 DS Tab. ACI

Rosiglitazone 2mg + metformin hydrochloride 1000mgitabiet (film-coated)

32's pack: 240.00 IP

.:. ROTAMIN 4 Tab. ACI

Rosiglitazone 4mg + metformin hydrochloride 500mg/tablet (film-coated) 30's pack: 255.00 IP

.:. ROTAMIN 4 DS Tab. ACI

Rosiglitazone. 4mg + metformin hydrochloride l OOOmgitablet (film-coated)

32's pack: 320.00 IP

.:. SENSIMET 1 Tab. Square

Rosiglitazone Img + metformin hydrochloride


.:. SENSIMET 1 DS Tab. Square

.:. AROMET·l Tab. Aristopharma

Rosiglitazone lmg + metformin hydrochloride

already treated with a combination of

500mgltablet (film·coated)

30's pack: 225.00 MRP

or ii. whose diabetes is not adequately controlled

.:. AROMET·2 Tab. Aristopharma

to diet and exercise to improve glycemic control

in patients with type 2 diabetes· i. who are

Rosiglitazone I mg + metformin hydrochloride

rosiglitazone and metformin as separate tablets,

30's pack: 1 20.00 MRP

with metformin alone, or iii. for those patients


lOOOmgitablet (film-coated)

.:. SENSIMET 2 Tab. Square


500mgitablet (film-coated)

who have initially responded to rosiglitazone

500mgltablet (film·coated)

CII; SIE; Precautions: See above under the text

.:. METARlN Plus Tab. Popular


preparations.

500mgitablet (film·coated)

30's pack: 300.00 MRP

recommended during pregnancy & lactation, so,

.:. METIGLIT 1 Tab. General Rosiglitazone Img + metformin hydrochloride

Rosiglitazone 4mg

alone and require additional glycemic control. of pioglitazone and metformin combined

Pregnancy & lactation: This combination is not . a suitable treatment schedule should be

prescribed with insulin.

Dosage & admin: General: The dosage of antidiabetic therapy with this combination should be individualized on the basis of the effectiveness and tolerability of the individual component of the product. All patients should start the rosiglitazone component of the combination at the lowest recommended dose. Further increases in the dose of rosiglitazone should be accompanied by careful monitoring for adverse events related to fluid retention.

30's pack: 180.00 MRP

Rosiglitazone

I mg + metformin hydrochloride

30's pack: 1 20.00 MRP

500mg/tablet (film·coated) 30's pack: 1 20.00 MRP

.:. METIGLIT 2 Tab. General

Rosiglitazone 2mg + metformin hydrochloride 500mgltablet (film·coated) 30's pack: 180.00 MRP

.:. ORAMET·PLUS Tab. Drug Inter.

Rosiglitazone 2mg + metformin hydrochloride 500mgltablet (film·coated) 50's pack: 350.00 MRP

.:. ROGMET 2 Tab. Pacific

30's pack: 1 80.00 MRP

.:. SENSIMET 2 DS Tab. Square 1000mg/tabiet (film-coated)

.:. SENSIMET 4 Tab. Square + metformin hydrochloride


Drugs for Diabetic Peripheral Neuropathy EPALRESTAT65 EPALRESTAT: Tablet Epalrestat is an aldose reductase inhibitor (ARI).

QIMP·15 (144)

DRUGS USED IN ENDOCRINE SYSTEM

It is available as epalrestat

tablet.

INN 50mg film coated

Mode of action: In diabetes mellitus, 'nerve fiber

2.1 Thyroid drugslhormones

the intensity Df their symptDms. ApprDpriate

2.2 Antithyroid drugs

adjustments Df the variDus therapeutic measures

2.3 Drugs for iodine deficiency goitre

directed at these cDncDmitant endDcrine diseases

degeneratiDn' and develDpment Df 'peripheral neurDpathy' starts by activating 'aidDse reductase

may therefDre be required.

pathway'. This pathway is activated by

Thyroid drugs & hormones

increased sDrbitDI fDrmatiDn in presence Df the

These include:

Pregnancy & lactation: WDmen Dn maintenance levDthyrDxine fDr hypDthyrDidism who. becDme pregnant shDuld nDt need to' alter the dDse

intracellular hyperglycemIa, resultmg m enzyme aldDse reductase that causes a

.. hyperosmDtic affects (accumulatiDn Df water and . swelling) Dn the nerves. This, in tum results m decreased mYD-inDsitDI fDrmatiDn, which breaks the enzyme Na+/K+. ATPase and ultimately causes decreased cellular activity (prDpagatlOn Df impulses and maintenance Df nerve cDnduction velocity) Df Na+/K+- ATPase. AldDse reductase inhibitDr (ARI) , epalrestat inhibits the enzyme aldDse reductase thus inhibits the process Df fDrmatiDn Df sDrbitDI and nerve damage. . symptDms and nerve dysfunctiDn in patients With

diabetic peripheral neurDpathy.

Ind: Epairestat is indicated fDr the improvement

Df subjective symptDms (numbness and pain), abnDrmality Df vibratiDn sense and abnDrmal change in heartbeat assDciated with diabetic

peripheral neurDpathy (when high

CII: KnDwn hypersensitivity to. epairestat. MajDr adverse reactiDns are hepatic

functiDn abnDrmalities and thrDmbocytDpenia. In cases Df hepatic abnDrmalities drug ShDUld be discDntinued immediately and appropriate

measures should be taken. Other reactiDns may

be malaise, headache, abdDminal pain, nausea, hypersensitivity reactiDn etc.

Precautions: The administratiDn Df epaIrestat

ShDUld be cDnsidered to. patients ShDwing high

glycDhemDglDbin values even after fundamental therapies fDr diabetes mellitus, such as· diet

therapy, exercise therapy and treatment With an

Dral hypoglycemic agent, insulin etc. The

. efficacy Df this product has nDt been establIshed in patients with diabetic peripheral neuropathy with irreversible Drganic changes. The patient

ShDUld be carefully mDnitDred during the

administratiDn Df this prDduct. When the efficacy Df this product is nDt Dbserved even after 12 weeks Df administratiDn, Dther appropriate , therapies ShDUld be taken.

Pregnancy & IacfLltWn: The safety Df epairestat in pregnant WDmen has nDt been establIshed. The

drug may be used in pregnant wDmen Dr m . wDmen who. may pDssibly be pregnant Dnly If expected therapeutic benefits Dutweigh the pDssible risks assDciated with the treatment. . Breast-feeding shDuld be aVOIded dunng administratiDn Df epalrestat.

is

SOmg 3 times daily before each meal. The dosage may

cDnfirmed to' be euthyrDid initially, by nDrmal

TSH levels. T4 dDse nDt cross the placental

Liothyronine.

barrier in the secDnd and third trimester, althDugh

be adjusted according to the

patient's age and symptoms.

.:. ALDORIN Tab. SK+F Epalrestat INN 50rrig/tablet (film-cDated). 24's pack: 192.00 MRP

2. THYROID & ANTITHYROID DRUGS2'

it may do. so. in early pregnancy. The amDunt Df

THYROXINEILEVOTHYROXINE21.26

T4 in breast milk is variable but nDt sufficient to.

THYROXINFJ LEVOTHYROXINE

Dosage & Admin: In adult patients witho�t cardac problems: initially adult oral dose IS

SODIUM: Tablet

�

Thyroxine sodium (levDthyrDxine sDdium) is . synthetic thyrDid hDrmDne, used m the thyroxme naturally occurring hDrmDne prDduced by the

thyroid gland & cDnverted to' the mDr active � hDrmDne tri·iDdDthyronine (T3) m penpheral

tissues. The thyroid hDrmDnes are required fDr nDrmal grDwth and develDpment particularly Df

the nervDus system. ThyrDxine sDdium

(levDthyrDxine sDdium) after ingestiDn is

incDmpletely and variably absDrbed from the

glycDhemDglDbin value is noted).

Dosage & admin: The usual adult dose

2.

because Df the pregnancy sO. IDng as they are

Thyroxine &

replacement therapy. ThyrDxine (T4) is a

Epalrestat, thereby improves subjective

AIR:

1.

gastrDintestinai tract. The half-life Df T4 in

. nDrmal plasma is 6-7 days, while that Df T3 IS

about I day. The plasma half-lives Df T4 and T3 are decreased in hyperthyrDidism and increased in hYPDthyrDidism. ThyrDxine sDdium (LevDthyrDxine sDdium) is largely bDund to'

plasma prDtein, mainly to. thyrDxine binding

glDbulin (TBG) but alSo. to. prealbumin and less

avidly to. albumin. The unbDund Dr free fractlDn, althDUgh Dnly abDut 0.03% Df tDtal thyrDxme

sodium (levDthyroxine sodium), is Df CDurse the

fractiDn available fDr peripheral actiDn and

cDnversiDn to' the mDre active metabDlite trio

iodDthyrDnine (T3).

Ind: I. CDngenital hYPDthyrDidism including

cretinism 2. Acquired hypothyroidism- primary

thyroid failure, autDimmune, PDSt surgery, PDSt

radiDiodine therapy, drug therapy, myxoedema 3. HypothyrDidism secDndary to.

. pituitarylhYPDthalarnic diseases 4. SuppressIOn

Df gDiter 5. In cDnjunctiDn with antlthyrDld drugs in treatment Df thyrotDxicDSis.

CII: ThyrDxine sodium (levDthyrDxine sodium) is cDntraindicated in patients with thyrDtDxicDSis, angina, cardiDvascular disDrders;

. hypersensitivity to. thyroid hDrmDne. It IS also. cDntraindicated in the patients with uncDrrected adrenal insufficiency.

SIE: Side-effects may include anginal pain, arrhythmias, paipitatiDn, skeletal muscle cramps, tachycardia, diarrhoea, vDmiting, tremDrs,

restlessness, excitability, insomnia, headache, flushing, sweating, fever, heat intDlerance,

excessive IDSS Df weight and muscular weakness. Precautions: Thyroxine sDdium (levDthyrDxine

sodium) ShDUld be used · with cautiDn in patients

with cardiDvascular disDrders, including angina, cDronary artery disease, and hypertension, and in the elderly who. have a greater

likelihDod Df

affect the nDrmal infant.

SO-I00mcg daily, preferably in the Casting

state, adjusted in steps oC 50mcg every 3·4

weeks until normal metabDlism maintained. The patient's well being and thyroid Cunction tests are reassessed after 6-8 weeks. The daily dosage may then require Curther minor adjustment so. as to ensure clinical and biochemial euthyroidism. It is impDrtant to correct any steroid deficiency first beCore initiating thyroxine replacement therapy. In the elderly and in patients with cardiac problems: Initially 25mcg daily or 50mcg on

alternate days adjusted in steps oC 2Smcg

Maintenance therapy: The usual maintenance dose

to relieve hypothyro·idism is l00·200mcg

daily, which can be administered a,s a single

dDse.

Neonates and children: Replacement therapy should be started as soon as the diagnosis is

made to prevent the mental and physical retardation that would otherwise occur. The initial diagnosis and cause can be reappraised when the inCant is 1 year Did. Dosage: At age 0-6 mon, 8-10mcg/kg/day;

. 6-12mon, 6-8mcg/kg/day; 1-5 yrs; 5-6mcg/kg/ day; 6-12 yrs; 4-Smcg; 12 years and over 2mcgtkg/day.

Over dosage: A massive acute DverdDse is

fDrtunately unCDmmDn, but pDtentially lethal. If the patient presents SDDn after ingestiDn Df an

acute DverdDse then gastric aspiratiDn and lavage are indicated. Other treatment indudes

prDpranDIDI and suppDrtive measures to. maintain the circulatiDn.

Drug inter: LevDthyrDxine; when given to. hypDthyroid patients who. are already Dn

anticDagulants, will pDtentiate the effect Df

warfarin and Dther dicDumarin anticDagulants necessitating a marked reductiDn (50%) in

warfarin dDsage to. prevent execessive

. prDIDngation Df the prDthrDmbin time and partial

thrombD-plastin time.

ChDlestyramine may reduce absDrptiDn Df

. levDthyroxine. PhenylbutazDne, carbamazepme

and phenytDin may cause a false IDW tDtal serum T4 levels. Serum T3 and TSH levels rather than T4 should be used to mDnitDr the patient's thyroid

status..

.

;: ELTROXIN Tab. GlaxoSmithKline

Dccult cardiac disease. Use Df thyrDxine sDdium

LevDthyroxine sodium 50mcg/tablet

(levDthyrDxine sDdium) in patients with


cDncDmitant diabetes mellitus, diabetes insipidus Dr adrenal cDrtical insufficiency may aggravate

..

every 4 weeks until euthyroid.

.:. EUTHYCIN Tab. lncepta

LevDthyroxine sDdium 50mcg/tablet

QIMP.15 (145)

100's pack: 120.00 MRP

-:- JAROXIN·50 Tab. Jayson Levothyroxine sodium SOmcgltablet l OO's pack: 1 20.00 MRP

-:- THYRONOR Tab. Nuvista Thyroxine sodium SOmcgltablet 30's pack: 60.00 MRP 100's pack: 200.00 MRP

salivary glands, laryngitis, bronchitis, rashes; on prolonged treatment depression, insomnia, impotence, myxoedema; goitre in infants of mothers taking iodides. Cautions: Pregnancy, children

Dose: 0.1·0.3 ml 3 times daily (well diluted with milk or water) for about 2 weeks. Prepa: May be available.

-:- THYROX Tab. Renata Thyroxine sodium SOmcgltablet 90's pack: 1 08.00 MRP

Antithyroid drugs These include: 1. 2. 3. 4.

Carbimazole Iodine & iodide Propyl thiouracil Propranolol

CARBIMAZOLE21.33 CARBIMAZOLE: Tablet Carbimazole is available as carbimazole BP Smgltablet. Ind: Thyrotoxicosis. CII: Tracheal obstruction, bre�t feeding. SIE: Nausea, headache , rashes, arthralgia, rarely alopecia, agranulocytosis. Advice patients to inform YOll of sore throats, mouth ulcer; if so, dicontinue drug. Cautions: Pregnancy. Pregnancy & lactation: Carbimazole is contraindicated in breast feeding mother. In pregnant woman it can only be given if it is clearly needed, but caution should be exercised. Dosage & admin: Adult: Moderate cases, 30

mg; severe cases, 4O·60mg. All daily in divided doses for 4-6 weeks; when the evidence of hyperthyroidism has disappeared, reduce to min. daily dose of 10·15mg to maintain control (treatment is usually maintained for 18 months). Child: 15 mg daily in divided doses. -:- CARBIZOL Tab. Square Carbimazole BP Smg/tablet. Smg x 60's pack: 1 80.00 MRP

Drugs for Iodine deficiency goitre LUGOLS IODINE SOLN.21 LUGOLS IODINE: Solution Aqueous iodine solution (iodine S%, potassium iodide 10%, made upto 1 00 parts in purified water), total iodine 1 30mglml. Ind: Pre-operative treatment of thyrotoxicosis SIE: Hypersensitivity like reactions, including headache, lachrymation, conjunctivitis, pain in

POTASSIUM IODIDE21 POTASSIUM IODIDE: Tablet Potassium iodide 60mgltablet Ind: Preoperative treatment of thyrotoxicosis. SIE; Cautions: Same as Lugol's iodine solution

Dose: 3O·60mg daily for about 2 weeks. Prepn: May be available.

3_ CORTICOSTEROID DRUGS/HORMONES21 Adrenal steroids are chiefly used i n medicine for the following purposes: I . Replacement therapy: In adrenocortical insufficiency, Addison's disease. 2. Glucocorticoid therapy: Mainly useful for its anti-inflammatory and immunosuppressive effects.

BETAMETHASONE21 .33 BETAMETHASONE: Tabet/lnjection Ind: Severe asthma, hayfever, allergic skin conditions, rheumatoid arthritis, collagen diseases, shock and adrenal crisis. CII: Tuberculosis, local or systemic infections unless controlled by chemotheraphy, herpes simplex keratitis, active peptic ulcer, psychoses, osteoporosis, renal dysfunctions, diabetes mellitus, glaucoma, hypertension, cushing's syndrome, myasthenia gravis, thromboembolic disorders, congestive heart failure, diverticulitis, fresh intestinal anastomoses and pregnancy. SIE: Hypertension, sodium retention, potassium loss, muscle weakness; diabetes; osteoporosis (particularly in elderly); mental disturbances; euphoria is frequently observed; peptic ulceration which may result in haemorrhage or perforation; suppression of growth (in children); spread of infections; adrenal suppression; menstrual irregularities. Overdoses may cause cushing's syndrome , with moon face striae, and acne. Cautions: Systemic corticosteroid therapy should be avoided in patients with psoriasis , as subsequent reduction commonly followed by a severe and persistent exacerbation; growth and development in infants & children on prolonged therapy should be observed; withdrawal of corticosteroid therapy should be gradually tapered to avoid symptoms of acute adrenal insufficiency. Dosage & admin: By mouth: Adults:


�

1. Rheumatoid arthritis eumatic Conditions: Initially 1·2.5mg daily; maintenance 0.5·1.5mg. 2. Acute rheumatic fever: 6·8mg daily; maintenance minimum effective dose. 3. Asthmatic attack: initially 3.5·4.5mg, maintenance, minimum effective dose; chronic refractory asthma 3.5mg daily, maintenance 0.5.2.5mg daily. 4. Allergic dermatosis: 2.5-4.5mg daily. 5. Inflammatory ocular conditions: 2.5·4.5mg daily; maintenance minimum effective dose. Children: Under 1 year, not recommended; 1· 7 years, 114 to 112 adult dose; 7·12 years 1/2 to 3/4 adult dose. By injection: (specially in shock, adrenal crisis & acute conditions). Adults: 4·20mg iv. repeated 3 or 4 times daily if required. Children: Upto 1 year Img; 1·5 years, 2mg; 6· 12 years 4mg. All by i.v. injection. -:- BETNELAN Tab. GlaxoSmithKline Betamethasone O.Smgltablet SOO's pack: 360.00 MRP

DEXAMETHASONE21 ,33 DEXAMETHASONE: Tablet/lnjection Ind: Severe asthma, hayfever, allergic skin conditions, rheumatoid arthritis, collagen diseases, shock and adrenal crisis. Cerebral oedema. CII; SIE; Cautions: See under betamethasone (above). Dosage & admin:

By mouth: Adult, 1.5·3 mg daily in divided doses, reducing by 0.25 or 0.5mg every 3 or 4 days to maintenance 0.5 ·1.5mg. daily. Cerebral oedema, initially 4·8 mg daily then 10·20mg daily. Children, under 1 year, not recommended; 1· 7 yrs 114 to 112 adult dose; 7·12 years. 1/2 to 3/4 adult dose, or O.OlO·O.04mgl kg. body·wt. By Injection: Adult · acute condition, such as shock, severe allergic reactions, fuliminating infections, hepatic coma and cerebral oedema, 8·40mg by slow i.v injection or infuction. Intra· articular, 2·4mg. Children· (above acute conditions) 0.25· 0.5mglkg body·wt. daily by slow i.v injection or infusion. -:- ALSONE Tab. AIco Pharma Dexamethasone O.Smgltablet 200's pack: 80.00 MRP

-:- AMASON Tab. Ambee Dexamethasone O.Smgltablet 1 00's pack: 46.00 MRP

-:- D·CORT Tab. Globe Dexamethasone O.Smgltablet 100's pack: 38.00 MRP

-:- D·CORT Inj. Globe Dexamethasone sodium phosphate Smg/Iml ampoule: injection


10 amps pack: 1 30.00 MRP .:. DECAFOS Inj_ Techno Drugs Dexamethasone sodium phosphate 5mg/lml

ampoule: injection 10 amps pack: 90.00 MRP .:. DECASON Tab. Opsonin Dexamethasone 0.5mg/tablet 200's pack: 100.00 MRP

QIMP-l (146)

.:. ORADEXON Tab. Nuvista Dexamethasone O.Smg/tablet. SOO's pack: 445.00 MRP .:. ORADEXON lnj. Nuvista Dexamethasone Smg/lml ampoule: injection 10 amps pack: 220.00 MRP .:. SONEXA Inj. Aristopharma Dexamethasone Smg/lml ampoule: injection 10 amps pack: 1 30.00 MRP

.:. DECASON Inj. Opsonin Dexamethasone sodium phosphate 5mgl1ml ampoule: injection 25 amps pack: 375.00 MRP

.:. STERON Tab. Acme Dexamethasone O.Smg/tablet. 1 00's pack: 4S .00 MRP

.:. DESON Tab. Zenith Dexamethasone 0.5mg/tablet lOO's pack: 1 25.00 MRP

HYDROCORTISONE21,33

.:. DEXA Inj. Renata Dexamethasone 5mg/lml ampoule: injection.

HYDROCORTISONE: Injection

10 amps pack: 1 50.00 MRP

Ind: Medical emergencies amenable to intensive

.:. DEXAM Tab. Medimet Dexamethasone 0.5mg/tablet. lOO's pack: 50.00 MRP

corticosteroid therapy e,g, status asthmaticus; acute adrenal crisis; cardiogenic haemorrhagic anaphylactic or septic shock; shock due to bum; overwhelming infections (with chemotherapy); Ulcerative colitis. CII; S/E; Cautions: See under Betamethasone (above). Dosage & admin: Adult: Shock, 100-500mg i. v repeated as necessary every 2-6 hours; Status asthmaticus, 500 mg. i.v. stat, may be repeated 4-6 hours later or followed by an infusion of 500 mg. every 4 hours; Acute adrenal crisis, 250 mg. i.v. then approximately 250mg. every 12 hours interval by i.v. infusion; Ulcerative colitis, 100mg. dissolved in 120 ml saline and administered as rectal drip. Child: Usual doses are 6-10mg/kg body wt. but 50 mg/kg body-wt. may be required if life threatening states. The dose should not fall below 25mg daily.

.:. DEXAM Inj. Medimet Dexamethasone 5mgl1 ml ampoule: injection.

10 amps pack: 128.80 MRP •:. DEXAMET Tab. Rephco Dexamethasone O.5mgltablet. 100's pack: 45.00 MRP

.:. DEXAME;T Inj. Rephco Dexamethasone sodium phosphate 5mg/lml

ampoule: injection. 10 amps pack: 100.00 MRP •:. DEXAMIN Tab. Jayson Dexameth�sone 0.5mg/tablet. 100's pack: 42.00 IP

.:. DEXAMIN Inj. Jayson Dexamethasone 5mgllml ampoule: injection 10 amps pack: 1 20.00 IP •:. DEXAN Tab. Chemist Dexamethasone 0.5 mg/tablet. 250's pack. 105.00 MRP

.:. DEXAN loj. Chemist Dexamethasone 5mg/l ml ampoule: injection 10 amps pack: 133.50 MRP .:. DEXATAB Tab. Renata Dexamethasone 0.5 mg/tablet.

250's pack. 150.00 MRP .:. DEXON Inj. Ibn Sina Dexamethasone 5mg/lml ampoule: injection.

10 amps pack: ISO.OO MRP .:. DEXTASON Tab. Ziska Dexamethasone 0.5 mg/tablet.

1 00's pack. 38.00 MRP .:. DEXTASON lnj. Ziska Dexamethasone Smg/lml ampoule: injection. 10 amps pack: 90.00 MRP .:. DEXASONE Tab. Pharmadesh Dexamethasone O.Smgltablet. 100's pack. 4S.00 MRP .:. G-DEXAMETHASONE Inj. Gonoshas. Dexamethasone Smg/lml ampoule: injection 10 amps pack: 98.60 MRP .:. GLUDEX Tab. Chemico Dexamethasone O.5mg/tablet. 100's pack. SO.OO MRP .:. MERADEXON Tab. Gaco Dexamethasone O.5mg/tablet. 100's·pack. SO.3S MRP .:. MERADEXON Inj. Gaco Dexamethasone Smg/lml ampoule: injection I ampoule pack: 9.81 MRP

.:. ANACORT Inj. Techno Drugs Hydrocortisone sodium succinate 100mg/2ml vial: injection 100mg (2ml) vial: 4S.00 MRP .:. CORTAID Inj. Novo Healthcare Hydrocortisone sodium succinate l OOmg/2ml

vial: injection 1 00mg (2inl) vial: 50.00 MRP .:. COTSON Ioj. Opsonin Hydrocortisone sodium succinate 100mg/2ml

vial: injection 100mg (2inl) vial: SO.OO MRP .:. G-HYDROCORTISONE Inj. Gonoshasthya Hydrocortisone sodium succinate l OOmg/2ml

ampoule: injection 100mg (2ml) amp x 5's pack: 200.00 MRP .:. HISON Inj. ACI Hydrocortisone sodium succinate 100mg/2ml vial: injection l OOmg (2ml) vial: 60.00 MRP .:. HYDROCORTISONE-Rotex Inj. Rotex Medica/City Overseas

Hydrocortisone sodium succinate 100mg/2ml vial: injection. 2ml vial: 56.00 TP .:. INTASONE Inj. Incepta Hydrocortisone sodium succinate 100mg/2ml

vial: injection 100mg (2ml) vial: 50,00 MRP

PREDNISOLONE21,33,40

PREDNISOLONE: Tablet/Injection.

Prednisolone is a synthetic glucocorticoid. It has 4 times the anti-inflammatory potency and 0.8 times the salt-retaining potency of the natural adrenocortical hormone, hydrocortisone. It is available as prednisolone USP 5mg normal & micronised tablet. Micronised tablet is easily absorbed from the gastro-intestinal tract. due to its special property. Ind: Bronchial asthma, allergic disorders, nephrotic syndrome, rheumatoid arthritis, rheumatic fever, allergic and inflammatory skin diseases; shock, pulm, oedema, cerebral oedema, status asthmaticus (as parenteral preparation). CII; S/E; Cautions: See under betamethasone (above) Dosage & admin: By mouth: Adult, 10-20mg daily in divided (2-3) doses reducing by 2.5 or 5mg every 3 or 4 days to maintenance 5-15mg daily. Child, under 1 year, not recommended; 1-7 yrs. 114 to half adult dose; 7-12years 112 to 3/4 adult dose.

By injection: By i.v or i.m injection, upto 100mg (as sodium phosphate); by i.m. injection, prednisolone acetate 25-100mg. Parenteral route usually used in acute conditions. After remission of acute symptoms, continue for a few days orally as mentioned above. .:. ADAM 33 Micro. Tab. Nuvista Prednisolone USP 5mg/tablet (micronised). 5mg x 300's pack: 261 .00 MRP .:. CORTAN Tab. Incepta Prednisolone Smg, I Omg & 20mg/tablet. 5mg x 200's pack: 150.00 MRP I Omg x l00's pack: 1 20,00 MRP 20mg x SO's pack: 107.S0 MRP .:. DELTACORT Tab. Desh Prednisolone 5mg/tablet. 5mg x 500's pack: 350.00 MRP .:. DELTAPRED Tab. Ziska Prednisolone Smg/tablet. 5mg x 500's pack: 350.00 MRP .:. DELTASONE Tab. Renata

Prednisolone 5mg/tablet. 5mg x 500's pack: 435.00 MRP IOmg x 100's pack: 144.00 MRP 20mg x 50's pack: 107.S0 MRP .:. G-PREDNISOLONE Tab. Gonoshasthaya Prednisolone 5mg/tablet 5mg x 30's pack: 1 2 ,00 MRP .:. PRECODIL Tab. Opsonin Prednisolone 5mg & 20mg/tablet 5mg x 200's pack: 140.00 MRP 20mg x 60's pack: 1 29.00 MRP .:. PREDNELAN Tab. GlaxoSmithKline Prednisolone 20mg/tablet 20mg x 100's pack: 250.00 MRP .:. PREDNICORTIL Tab. Gaco Prednisolone 5mgltablet 5mg x 100's pack: 64.93 MRP .:. PREDNISOLONE Tab. Ambee Prednisolone 5mg/tablet 5mg x 500's pack: 330.00 MRP .:. PREDNISOLONE Tab. GlaxoSmithKline Prednisolone 5mg/tablet Sing x 500's pack: 400.00 MRP .:. PREXAN Tab. Chemist Prednisolone.5mg/tablet

Q�.15 (147)


Smg x SOO's pack: 3S0.00 MRP

betamethasone.

Ind: Allergic disease, dermatoses or generalized

.:. REDNISONE Tab. Rephco

Pregnancy & lactation: Please see above under

rheumatoid arthritis and other connective tissue

Prednisolone Smg/tablet

the text of methyl prednisolone acetate.

disorders. May also be given by intra-articular or

Smg x SOO's pack: 260.00 MRP

Indications & Dosage: 1. As

intra-bursal administration in traumatic arthritis,

:. ZENILON Tab. Zenith

•

adjunctive therapy in life-threatening conditWns- the

synovitis, bursitis and tendinitis .

C/I:

Local for systemic viral infections,

Prednisolone Smg/tablet

recommended dose is 30mg!kg given i.v over a

Smg x 100's pack: 17S.OO MRP

period of at least 30 minutes; this dose may be

tuberculosis, active peptic ulcer, acute

METHYL PREDNISOLONE21 .60

Corticosteroid responsive diseases in exacerbation and/or unresponsive to standard therapy- suggestive schedule:

contraindication for corticosteroid therapy Local administration is contraindicated in

i. Rheumatic disorders: Igm/day for 1, 2, 3 or

presence of active infections.

METHYL PREDNISOLONE: Injection Methyl prednisolone acetate 40mglml; hnl & 2ml vial: injection Ind: Rheumatoid arthritis, inflammatory and allergic conditions, osteoarthritis, cerebral oedema. CII; SIE; Cautions: See under betamethasone (above). Pregnancy & lactation: There are no adequate & well-controlled studies in pregnant women. As animal reproduction studies are not always predictive of human response, this drug should be used during pregnancy only if clearly needed. Prednisolone is excreted in b;east milk, it is reasonable to assume that as all corticosteroids appear in small amounts in breast milk, methyl prednisolone acetate may also appear in breast milk, but no specific data in known for methyl prednisolone acetate. A maternal dose of prednisolone up to 40mg daily is unlikely to cause systemic effects in the infants. Therefore, infants should be monitored for adrenal suppression if the mothers are taking a higher doses. Dosage & admin: Rheumatoid & osteoarthritis: The dosage depends upon the s� of the joint and severity of the conditions; max. dose may be upto 120 mg. Injection may be repeated if needed at an interval of 1 to S or more weeks depending upon the degree of relief obtained from initial dose.

Dermatological conditions: 40·120mg (1-3ml). Allergic conditions: 80-120mg (2-3ml). Collagen diseases: 40·120mg (1-3ml) repeated 2-3 weekly if required.

Adrenogenital syndrome: 40mg (Iml) every 2 weeks.

Note: For further information, please consult manufacturer's literature. :. DEPO-MEDROL Inj. Pharmacia-Pfizer/

•

Janata Methyl prednisolone acetate 40mglml; Iml & 2ml vial: injection Iml (40mg) vial: 1 0 1 .73 MRP 2ml (80mg) vial: 12S.67 MRP .:. MEDROL Inj. Techno Drugs Methyl prednisolone acetate 40mglml; I ml & 2ml vial: injection Iml (40mg) vial x 5's pack: 32S.00 MRP 2ml (80mg) vial x I 's pack: 90.00 MRP

repeated evry 4·6 hours for up to 48 hours.

2.

SIE: Cushingoid syndrome, weakness, bruising

ii. Systemic Inpus erythematosus (SLE):

or purpura, masking of infections, activation or

Igm/day for 3 days i.v.

iii. Multiple sclerosis: Igm/day for 3 days or S

menstrual cycle, hirsutism, acnel form eruptions.

iv. Oedematous states: e.g glomerulonephritis,

There should be gradual termination in dosage.

lupus nephritis: 30mg!kg every other day for 4

Dosage & Admin:' For children from 6 to 12

days i.v or 19m!day for 3, S or 7 days i.v.

years, initial dose is 4Omg. Initial systemic

3. Mild to moderately emetogenic chemotherapy: Administer 2S0mg i.v over at

40 to 80mg. For adults maximum daily dose is

least S minutes 1 hour before chemotherapy,

80 to l00mg. For local areas, dose for adults is upto 10mg for smaller and 40mg for larger

time of discharge. A chlorinated phenothiazine

areas.

may also be used with the first dose of methyl prednisolone sodium succinate injection for increased effect. 4.

Severely emetogenic chemotherapy:

Administer methyl prednisolone sodium succinate 2S0mg i.v over at least S minutes with appropriate dosage of metoclopramide or a butyrophenone 1 hour before chemotherapy, then 2S0mg i.v at the initiation of chemotherapy & at the time of discharge.

S. ln other indications: Initial dosage will vary from 10 .10 SOOmg depending on the clinical problem being treated. Larger dosage may be required for short·term management of severe, acute conditions. The initial dose, up to 2S0mg, should be given i.v over a period of at least S minutes; subsequent dosage may be given i.v or i.m at intervals dictated by the patients response & clinical conditions. Corticosteroid therapy is an adjunct to & not replacement for, conventional therapy. Dosage may be reduced for infants & children but

.:. CYNOCORT Inj. Techno Drugs Triamcinolone acetonide 40mglml: i.m injection. Iml amp: 60.00 MRP .:. KENACOL Tab. Skylab Triamcinolone BP 4mg/tablet lOO's pack: 290.00 MRP .:. KENACORT-A Inj. Squihb/ Kapricorn Triamcinolone acetonide 40mglml : i.m injection. 1 ml amp: 68.27

MRP

.:. TRIALON Inj. Drug Inter. Triamcinolone acetonide 40mglml: i.m injection. I ml amp x 3's pack: 1 80.00 MRP .:. TRIMCORT Inj. Chemist Triamcinolone acetonide 40mg/ml: i.m injection. Iml amp x 2's pack: 1 20.00 MRP

4. SEX HORMONES2 1 Sex hormoues are discussed under the following hroad headings:

should be governed more by severity of the

1

condition & respOnse of the patient than by

2

Male sex hormones

age or size.

3

Anabolic steroids

4

Oral Contraceptive prepns.

It should not be less than O.Smg!kg

every 24 hours•

Female sex hormones

Methyl prednisolone sodium succinate may be administered by i.v or i.m injection or by i.v infusion, the preferred method for initial

Female Sex hormones

emergency use being intravenous injection. Note: For further information, please consult manufacturer's literature. .:. SOLU-MEDROL Inj. Pharmacia· Pfizer/Janata Methyl prednisolone sodium succinate 40mg, 1 2Smg, SOOmg & l gm vial: injection

I gm vial x I 's pack: 168S . 1 7 MRP

SUCCINATE: Injection

TRIAMCINOLONE21 .J J

, Ind: See below with the dosage. CII; SIE; Cantions: See above under the text of

dose for adults and children over 12 years is

at the initiations of chemotherapy, & at the

SOOmg vial x I 's pack: 10 1 LOS MRP

1 2Smg, SOOmg & 1 9m vial: injection

aggravation of peptic ulcer, activation of latent or aggravation of existing diabetes, altered

days i.v.

12Smg vial x l's pack: 498.40 MRP

Methyl prednisolone sodium succinate 40mg,

particularly in the first trimester of pregnancy.

4 days i.v or Img/month for 6 months i.v.

40mg vial x I ' s pack: 299.03 MRP

METHYL PREDNISOLONE SODIUM

glomerulonephritis. Pregnancy is relative

There are two groups of female sex hormones: 1. Oestrogens & 2. Progestogens.

OESTROGENS21 .33 Oestrogen is a female sex hormone produced by the ovary & also by the placenta during pregnancy. The most potent natural oestrogen is estradiol-1 7 � . In terms of oestrogenic activity natural oestrogens (oe�tradiol, oestrone & oestriol) have a more appropriate profile for hormone replacement therapy (HRT) than synthetic

TRIAMCINOLONE: TabletlInjection

oestrogens (ethinyloestradiol, mestranol &

QIMP-1S (148)

DRUGS USED IN ENDOCRINE SYSTEM stilboestrol); the profile of conjugated oestrogens resembles that of natural oestrogens. Oestrogen therapy is given cyclically or continuously for a number of gynaecological conditions. If long-term therapy is required a progestogen should

be added to reduce the risk

of cystic hyperplasia of the endometrium and

possible transformation to cancer. This addition of a progestogen is not necessary if the patient has had a hysterectomy or in the case of tibolone.

surgery.

Climacteric complaints such , as

hot flushes

of thromboembolic disease. Undiagnosed vaginal

For maintenance therapy the first week,

SIE: Nausea & vomiting, wt. gain, breast

first week, followed by a gradual reduction. followed by a gradual reduction. For

maintenance therapy the lowest effective

bleeding.

enlargement and tenderness, withdrawal bleeding, sodium retention with oedema, changes in liver

dosage should be used.

function, jaundice, rashes and chloasma,

cervical smear: 2-4mg per day for 7 days

post-menopausal women.

A diagnostic aid in case of a doubtful atrophic

depression, headache, endometrial carcinoma in

before taking the next smear.

Dosage & admin: Adult-Menopausal, usually

1-2mg per day on days 6-15 of the menstrual

on 5th day of menstruation then repeat after

cycle. However, for some patients dosages as

ESTRIOL: TableUCream

Severe cardiac, hepatic or renal disease. History

and night sweating: 4-Smg per day during the

Infertility due to cervical hostility: In general

ESTRIOL" ·47

Endometriosis. Uterine or mammary carcinoma.

low as 0.25mg per day are sufficient. Whereas

0.625mg or 1.25mg daily for 21 days starting 7 days. Postmenopausal osteoporosis,

cyclically 0.625mg or 1.25mg daily. Functional

Estriol is a natural oestrogenic hormone.

others may need up to Smg per day.

amenorrhoea, 0.625mg or 1.25ritg daily for 21

CII: Pregnancy; thrombosis; known or suspected

each month until an optimal effect on the

should be added.

Ind: See below under the individual preparation.

oestrogen-dependent tumours; undiagnosed vaginal bleeding; a history of manifestation or deterioration of otosclerosis during pregnancy or previous use of steroids.

S/E: Breast tensiOil or pain, nausea, spotting. fluid retention and cervical hypersecretion may occasionally occur and be indicative of too high a dosage. Headache, hypertension, leg cramps and vision disturbances are seldom observed. In general most of these adverse reactions disappear after the first treatment week.

Pregnancy & lactation: This medicine is contraindicated during pregnancy. There are

insufficient data on the use of this medicine during breast-feeding to assess potential harm to

Therefore, the dosage should be increased cervical mucus is obtained.

Administration: Ovestin tablets should be

taken orally, preferably with some fluid. It is

important that the total daily dose is taken at

one time.

days. For the last 7 days progesteron therapy Child: Not applicable.

.:. EQUIN 0.6 Tab. Aldo-Union, Spain! Medinam Conjugated oestrogens (equine) 0.625mgltablet. 0.625 mg x 28's: 360.00 MRP

30's pack: 240.00 MRP

.:. PREMARIN Tab. Ayerst

.:. OVESTIN Cream Nuvista

Conjugated oestrogens (equine) 0.625mg &

Estriol I mglgram: cream.

1 .25mgltablet.

Ind: see under the doses.

0.625 mg x l oo's: 202.60 MRP

under the text of estriol. As ovestin cream is

Note: Prices could not be revised; but

CII; SIE; Warnings & Precautions: See above applied to the mucosal surfaces, it may cause local irritation or itching.

Indications & Dosage: Atrophy of the lower

1 .25 mg x l oo's: 349.70 MRP

preparations may be available in the market.

.:. PREMARIN I.V. Inj. Ayerst

Conjugated oestrogen 25mg in 5ml ampOUle: i.v

urogenital tract related to oestrogen dficiency

injection

production.

recurrent infections of the va gina and lower

CII & SIE: Same as tablet prepn.

I . In order to prevent endometrial stimulation,

incontinence:

the inant. It is known, bowever, that estriol is excreted in breast milk and may decrease milk

urinary tract including mild urinary

Warnings & precautious: the daily dose should not exceed 8mg (or I application of intravaginal cream- 0.5mg estriol) nor should this maximum dose

. leading to dyspareunia, dryness and itching,

be used for

longer than several weeks. 2. During prolonged treatment with oestrogens, periodic medical examinations are advisable. 3. With vaginal infections, a concomitant specific

t application per day for

the

first week, followed by a gradual reduction, . based on relief of symptoms, until a

Ind: Severe uterine haemorrhage; Breast cancer.

Adult: By slow i.v injection 25mg. repeat after 6-12 hours

if required. Child:

Not applicable.

1 amp. 173.50 MRP Note: Prices could not be revised; but

maintenance dosage (e.g. 1 application twice a


incontinence a higher maintenance dosage will

Conjugated oestrogen 0.625mg in I gm: non

week) is reached. In certain cases of urinary be required.

Pre- & postoperative therapy in post

.:. PREMARIN Vaginal Cream Ayerst.

Iiquifying cream.

Ind: Atrophic vaginitis; pruritus vulvae; before

menopausal women undergoing vaginal

and after postmenopausal surgery.

adverse effects as with other oestrogens.

before surgery; 1 application twice a week in

using calibrated applicator for 3 weeks

individual preparation.

A diagnostic aid in case of a doubtful atrophic

Child: Not applicable.

.:. OVESTIN Tab. Nuvista

in the week before taking the smear.

treatment is recommended. 4. Patients also should be monitored for the other

Dosage & Admin:

see below under the

Estriol I mgltablet.

Ind: See under the doses.

CII; SIE; Warnings & Precautions: See above under the text of estriol.

Indications & Dosage: Atrophy of the lower

urogenital tract related to oestrogen dficiency leading to dyspareunia, dryness and itching,

recurrent infections of the va gina and lower urinary tract including mild urinary

surgery: 1 application per day in the 2 weeks the 2 weeks after surgery.

cervical smear: 1 application on alternate days

Adult: 1-2gm daily topically or intravaginally

followed by 1 week rest.

42.5 gm. tube: 170.80 MRP

Note: Prices could not. be revised; but

Administration: Ovestin cream should be


calibrated applicator before retiring at night. 1

Conjugated oestrogens USP 0.625mg/tablet

contains 0.5gm ovestin cream which

0.625mg x 28's: 1 40.00 MRP

administered intravaginally by means of a

application (applicator filled to the ring mark)

corresponds with 0.5mg estriol.

15gm tube with applicator: 1 1 14.00 MRP

.:. PREMlCON Tab. Techno Drugs

(film-coated).

PROGESTERONE21 .33.40.70

incontinence: 4-Smg per day for the first week,

CONJUGATED OESTROGENS

PROGESTERONE: TableUGeVPessary

relief of symptoms, until a maintenance dosage

CONJUGATED OESTROGENS: Tablet

a female sex hormone produced by the corpus

followed by a gradual reduction, based on (e.g. 1-2mg per day) is reached. In certain

cases of urinary incontinence a higher maintenance dosage will be reqnired.

Pre- & postoperative therapy in post

menopausal women undergoing vaginal

surgery: 4-Smg per day in the 2 weeks before

surgery; 1-2mg per day in the 2 weeks after

Description & mode of action: Progesterone is

Conjugated oestrogens (equine) 0.625mg &

luteum, which develops from the ruptured

1 .25mgltablet.

ovarian follicle immediately after ovulation i.e

replacement; post-menopausal osteoporosis;

emerges at mid-cycle. Progesterone then

senile vaginitis, functional amenorrhoea,

promotes transformation of the oestrogen-primed

Ind: Menopausal & post-menopausal oestrogen

prostatic carcinoma.

CII: Pregnancy. Uterine myomatosis.

the empty follicle that remains when the ovum

endometrium, as a result, the endometrium is transformed into an environment that is receptive

QIMP-1S (149)

to embryo implantation and able to support early pregnancy. Synchronization between embryo development and endometrial receptivity begins with ovulation and production of progesterone by the corpus luteum. The embryo arrives in the uterine cavity from the fallopian tube 4 to 5 days after ovulation-cycle day 1 8 or 19 at the morula stage, but does not implant until day 20 or 21 at the blastocyst stage. At that time, there is peak activity of the glands of the endometrium and it is best prepared to support the embryo. Thus, it is clear that the establishment of pregnancy depends not only on successful fertilisation and embryo quality but on endometrial receptivity to embryo implantation. Progenterone is clearly a critical hormone in aChieving and maintaining pregnancy. This hormone is essential for the preparation of the endometrium for implantation; it is also essential for the maintenance of a viable pregnancy. If progesterone is withdrawn, miscarriage will occur. Ind: See below under individual preparation. CII: Progesterone should not be used in individuals with any of the following conditions: I . Pregnancy or suspected pregnancy. 2. Known sensitivity to progesterone. 3. Undiagnosed vaginal bleeding. 4. Liver dysfunction or disease. 5. Known or suspected malignancy of the breast or genital organs. 6. Missed abortion. 7. Active thrombophlebitis or thromboembolic disorders, or a history of hormone-associated thrombophlebitis or thromboembolic disorders. Adverse effects: Nausea, weight-gain, headache, depression, changes in libido, breast enlargement, altered menstrual cycles, virilisation of foetus, acne, urticaria. Also see under the individual preparation. Warnings: The physician be alert to the earliest manifestations of thrombotic disorders (thrombophlebitis, cerebrovascular disorders, pulmonary embolism, and retinal thrombosis). If any of these occur or be suspected, the drug should be discontinued immediately. Progesterone and progestins have been used to prevent miscarriage in women with history of recurrent spontaneous pregnancy losses. But, no adequate evidence is available to show that they are effective for this purpose. Precautions: GeneralI . The pretreatment physical examination should include special reference to breast and pelvic organs, as well as papanicolaou smear. 2. In cases of breakthrough bleeding, as in all cases of irregular vaginal bleeding, nonfunctional causes should be considered; in cases of undiagnosed vaginal bleeding, adequate diagnostic measures should be undertaken. 3. Because progestogens may cause some degree of fluid retention, conditions which might be influenced by this factor (e.g epilepsy, migraine, asthma, cardiac·o r renal dysfunction) require careful observation. 4. The pathologist should be advised of progesterone therapy when relevant specimens ·are submitted. 5. Patients who have a history of psychic

depression should be carefully observed and the drug discontinued if the depression recurs to a serious degree. 6. A decrease in glucose tolerance has been observed in a small percentage of patients on estrogen-progestin combination drugs. The mechanism of this decreaes is not known. For this reason, diabetic patients should be carefully observed while receiving progestin therapy. 7. In case of intravaginal gel preparation or pessary, the patient should be advised not to use concurrently with other local intravaginal therapy. If it is needed to be used concurrently, there should be at least a 6-hour interval. Dosage & admin: Please see below under the individual preparation,

.:. CRINONE 8 %

Healthcare

Gel Serono/Janata

Crinone is a bioadhesive vaginal gel preparation, containing micronized progesterone 8% in an emulsion system, which is contained in single use, one piece polyethylene vaginal applicators. (There is also another preparation with low strength - Crinone 4%, not available in our market). Ind: i. Assisted reproductive technology Crinone 8% (90mg) is indicated for progesterone supplementation or replacement as part of an assisted reproductive technology ('ART) treatment for infertile women with progesterone deficiency. ii. Secondary amenorrhea - Cnnone 4% is indicated for the treatment of secondary amenorrhea. Crinone 8% (90mg) is indicated for use in women who have failed to respond to treatment with crinone 4%. CII: Please see above under the text of progesterone. Adverse reactions: Assisted reproductive

In a study of 61 women with ovarian faliure undergoing a donor oocyte t ransfer procedure receiving progesterone 8% (90mg) twice daily, treatment-emergent adverse events occurring in 5% or more of the women are as follows: Body as a whole- bloating, cramps, pain; Central and peripheral nervous system- dizziness, headache; Gastrointestinal system- nausea; Reproductive- breast pain, genital moniliasis, vaginal discharge; Skin and appendages- genital pruritus. In a second study of 1 39 women using progesterone 8% (90mg) once daily for luteal phase support while undergoing an 'in vitro fertilization' procedure, treatment-emergent adverse events reported in 5% or more of the women are as follows: Body as a whole- abdominal pain, perineal pain; technology (ART):

Central and peripheral nervous system

headache; Gastrointes-tinal system- constipation, diarrhea, nausea, vomiting; Musculoskeletal system- arthralgia; Psychiatric- depression, libido decreased, nervousness, somnolence; Reproductive- breast enlar-gement, dyspareunia; Urinary system- nocturia. Secondary amenorrhea:

In three studies, 127 women with secondary amenorrhea received estrogen replacement therapy and progesterone 4% or 8% every other day for six doses. Treatment emergent adverse


events during estrogen and progesterone treatment that occurred in 5% or more of women are as follows: Body as a whole- abdominal pain, appetite increased, abnormal crying, allergic reaction, allergy, asthenia,. edema, face edema, fever, hot flushes, influenza-like symptoms, water retention, xerophthalmia decreased, asthenia, edema, face edema, fever, hot flushes, influenza-like decreased, asthenia, edema, face edema, fever, hot fiushes, influenaz-Iike symptoms, water refention, xerophthalmia. bloating, cramps, fatigue; Central and peripheral nervous system- headache; Gastrointestinal system- nausea; Musculoskeletal system- back pain, myalgia; Psychiatric depression, emotional lability, sleep disorder; Reproductive- vaginal discharge; Resistance mechanism- upper respiratory tract infection; Skin and appendages- genital pruritus. Additional adverse events reported in women at a frequency < 5% in progesterone ART and secondary amenorrhea studies include: Body as a whole- abnormal crying, allergic

reaction, allergy, appetite decreased, asthenia, edema, face edema, fever, hot flushes, influenza like symptoms, water retention, xerophthalmia; CVS- syncope; Central and peripheral nervous system- migraine, tremor; Autonomic nervous system- dry mouth, increased sweating; Gastrointestinal- dyspepsia, eructation, flatulence, gastritis, toothache; Metabolic & nutritional- thirst; Musculoskeletal system- leg cramps, leg pain, skeletal pain; Neoplasm-benign cyst; Platelet, bleeding & clotting- purpura; Psychiatric- aggressive reactions, forgetfulness, insomnia; RBC- anemia; Reproductive- dysmenorrhea, premenstrual tension, vaginal dryness; Resistance mechanism infection, pharyngitis, sinusitis, urinary tract infection; Respiratory system- asthma, dyspnea, hyperventilation, rhinitis; Skin and appendages- acne, pruritis, rash, seborrhea, skin discoloration, skin disorder, urticaria; Urinary system- cystitis, dysuria, micturition frequency; Vision disorder conjunctivitis. Warnings & Cautions: Please see above under the text of progesterone. Pregnancy & lactation: Progesterone 8% (90mg) has been used to support embryo implantation and maintain pregnancies through its use as part of ART treatment regimens in two clinical studies. In the first study, 54 women were treated with progesterone 8%. Out of them clinical pregnancies occurred in 26 women (48%). Among these 26 pregnancies, one woman had an elective termination of pregnancy at 19 weeks due to congenital malformations (omphalocele) associated with a chromosomal abnormality; one woman pregnant with triplets had an elective termination of her pregnancy; seven women had spontaneous abortions; and 17 women delivered 25 apparently normal newborns. In the second study, progesterone 8% (90mg) was used in the luteal phase support of women undergoing 'in vitro fertilization (IVF)' procedures. In this multi-centre, open-label study, 139 women received progesterone 8% (90mg) once daily beginning within 24 hours of embryo

QIMP-15 (ISO)


newborns delivered, one had a teratoma

symptoms present at ovulation, start by day 12_ Post- natal depression: 200mg or 400mg once or twice a day, rectally, till menses occur_ Luteal pbase support: 400mg twice daily vaginally or rectally_ Overdosage: There is a wide safety margin, but

distress syndrome; 44 were apparently normal

dysmenon;hoea.

transfer and continuing through day 30 past

transfer. Clinical pregnancies assessed at day 90

post-transfer were seen in 36 women (26%). 32

women (23%) delivered newborns & 4 women (3%) had spontaneous abortions. Of the 47(?)

associated with a cleft plate; one had respiratory

& one has lost to followup.

Detectable amounts of progestins have been

identified in the milk of mothers receiving them. The effect of this on the nursing infant has not been determined. Pregnancy: progesteron 8% (90mg)

Dosage & admin: Assisted reproductive technology (ART): Progesterone 8 % (90mg) is adminis-tered vaginally at dose of 90mg once daily in women wbo require progesterone . supplementation_ Progesterone 8 % (90mg) is adminis-tered vaginally at a dose of 90mg twice daily in women with partial or complete ovarian failure wbo require progesterone replacement_ If pregnancy occurs, treatment may be continued until placental autonomy .is acbieved, uP to 10-12 weeks_ Secondary amenorrhea: Progesteroue 4 % is administered vaginally every otber day up to a total of six doses_ For womeu wbo fail to respoud, a trial of progesterone 8 % (90mg) every otber day up to a total of six doses may be iustituted_ It is important to note tbat a dosage increase from tbe 4 % gel can only be accomplisbed by usiug tbe 8 % gel. Increasing tbe volume of gel administered dose not increasee tbe amount of progesterone absorbed. How to use Crinone: Please consult the manufacturer's insert. Drug inter: No drug interactions have been assessed with crinone.

Price:

Crinone 8% single-use prefilled applicator x 15's pack: 4288.53 MRP

overdosage may produce euphoria or

400mg pessary x 15 pes box:

6 ALLYLESTRENOL 2 ALLYLESTRENOL: Tablet

Allylestrenol is an orally active gestagen. It is an effective and safe pregnancy maintaining

preparation. It is available as 5mg tablet for oral administration.

Mode of action: Allylestrenol has a pronounced pregnancy maintaining action in castrated

animals without producing hormonal side-effects. [n the human, premature termination of

pregnancy often follows a fall in the levels of placental hormones. Allylestrenol has been

shown to stimulate the placental progesterone

production in vitro and to promote the secretion of placental hormones (human chorionic

gonadotrophin, human placental lactogen,

oestrogens and progesterone) and oxytocinase in patients with pregnancy at risk. In agreement to

this the trophoblastic layers of the placenta show

histological signs of activation. Clinical studies have indicated that allylestrenol is an effective and safe pregnancy maintaining preparation.

Administration of allylestrenol in combination

with bed rest can remove or prevent the threat of

abortion in early pregnancy or stop threatened

premature labor.

Ind: Threatened abortion, habitual abortion;

threatened premature labor.

CII: There are no known contra-indications.

AIR: Allylestrenol is generally well tolerated. Serious adverse reactions have neither been

reported in the mother nor in the offspring.

.;. CYCLOGEST Pessary Actavisffajaratl40

Gastrointestinal complaints (nausea, vomiting)

vaginal or rectal insertion.

Precautions & warnings: No warnings or

menstrual syndronide, post- natal depression, &

Dosage & admin: Tbreatened abortion: 5mg tbree times daily for 5-7 days_ If necessary, tbe treatment period may be extended_ After disappearance of tbe symptoms the dosage sbould be gradually reduced unless symptoms return. Habitual abortion: 5-10mg daily as soon as pregnancy has been diagnosed_ Tbe administration sbould be continued until at least one montb after tbe end of tbe critical period_ Threatened premature labor: Tbe dosage must be determined individually. Higb dosages (up to 40mg daily) bave been used.

Each pessary contains 400mg progesterone: For

Ind: Habitual abortion, threatened abortion, pre

luteal phase support.

CII: See above under the text of progesterone. SIE: See above under the text of progesterone.

Menstruation may occur earlier than expected, or

be delayed. Soreness, diarrhoea and flatulence

with rectal application. Leakage of pessary base.

Precautions & warnings: See above under the text of progesterone.

Hepatic dysftunction, conditions that may be hromone sensitive. Warnings: Use rectally if

barrier methods of contiaception are used, if

patient has vaginal infection, recurrent cystitis, or has recently given birth. Use vaginally where

colitis or faecal incontinence present.

Dosage & application: Habitual abortion: 400mg twice a day rectally or vaginally for 3 montbs_ Threatened abortion: Starting dose 800mg rectally, followed by 400mg every 12 bours, till bleeding stops_ Pre-menstrual syndrome: Start on day 14 of cycle witb 200mg or 400mg once or twice a day, vaginally or rectally, continue until menstruation starts; if

have been reported occasionally. precautions are applicable.

.;. GESTRENOL Tab_ Renata Allylestrenol 5mgltablet

30's pack: 240.00 MRP

LYNESTRENOL4D LYNESTRENOL: Tablet

Lynestrenol is a progestogenic agent specially

effective in correcting different menstrual

disorders due to hormonal imbalance. It is

available as 5mg tablet.

Indications & Dosage: Polymenorrhoea- 1 tab_ daily on days 14-25 of the cycle_ Menorrhagia & Metrorrhagia- 2 tabs_ daily for 10 days_ Usually tbe bleeding will cease within a few days after the start of the treatment. Treatment is repeated during tbe next 3 menstrual cycles witb 1 tab_ daily on days 1425 of each cycle. Further diagnostic procedures are necessary if the complaints do not disappear during or after tbis treatment_ Selected cases ofprimary and secondary amenorrhoea and oligomenorrhoea- Treatment should start with the adminis-tration of an estrogen, e.g 0.02-0_05mg etbinylestradiol per day for 25 days. In conjunction witb tbis, 1 tab_ daily of Orgametril is administered on days 14-25_ After cessation of treatment, a witb- drawal bleeding usually occurs witbin 3 days_ Treatment is resumed (second cycle) starting on day 5 of this withdrawal bleeding witb the estrogen given on days 5-25 of the cycle and again with 1 tab_ daily of Orgametril on days 14-25_ Tbis treatment should be repeated for at least another cycle_ Premenstrual syndrome- 1 tablet daily on days 14-25 of tbe cycle_ Endometriosis- 1-2 tablets daily for at least 6 months_ Selected cases of endometrial carcinoma- 6-10 tabs_ daily for prolonged periods_ Benign breast disease- 1 tablet daily on days 14-25 of tbe cycle or at least 3-4 montbs_ Suppression of menstruation, ovulation and ovulation pain; dysmenorrhoea- Treatment with 1 tab_ daily sbould start preferably on day 1, but no later tban day 5 of the cycle_ Tbe treatment can be continued for many montbs (without tablet-free days)_ If in spite of treatment, a breaktbrough bleeding occurs, the dosage sbould be increased to 2 or 3 tabs_ daily for 3-5 days_ Postponement of menstruation- Treatment witb 1 tab_ daily sbould start preferably 2 weeks before the expected onset of menstruaton_ If treatment is started less than 1 week before the expected onset of menstruation the dosage should be 2-3 tabs_ per day_ However, in tbat case a delay of more tban 1 week is undesirable_ Tbe risk of breakthrough bleeding increases if treatment is started later_ Therefore, treatment should not be started later than 3 days before tbe expected onset of menstruation_ As an adjunct to estro gen therapy in peri-and postmenopause, in order to avoid endometrial hyperplasia- 1/2 - 1 tablet daily for

12-15 days per month, e_g_ for tbe first 2 weeks of every calendar montb; tbe estrogen may be administered daily without tablet free intervals at the lowest effective dose_ Administration: Orgametril tablet sbould be taken orally with some fluid_

QIMP-IS (151)

Note: Throughout the text, take the first day of the menstrual bleeding as day 1 of the cycle. CII: Please see above under the text of progesterone.

AIR: During continuous treatment regimens breakthrough bleeding or spotting will occur frequently (over 10%) during the first two months. During cyclic treatment regimens breakthrough bleeding and spotting will be seen occasionally ( 1 - 1 0%). Temporarily increasing the dose will control the bleeding in most cases. Other adverse effects- almost same as other progestogenic hormones.

Cautions & warnings: Please see above under the text of progesterone.

.:. ORGAMETRIL Tab. Nuvista Lynestrenol Smg/tablet. 30's pack: 268.80 MRP

under the text of progesterone. Dosage & admin: Adult: Postponement of

mens.- Smg 3 times daily starting 3 days before expected onset of menstruation. Dysmenorrhoea- 5mg 3 times daily for 20 days starting on 5th day of menstruation, then 8 tablet·free days_ Maintain treatment for 3 or 4 cycles. Menorrhagia and pre-menstrual syndrome. Smg. 2 or 3 times daily from day 19-26 of cycle. Child: Not applicable. .:. NORCOLUT Tab. Gedeon RichterlCity Overseas Norethisterone Smgitablet. 20's pack: 14S.00 TP

.:. NORMENS Tab. Renata Norethisterone Smgitablet. 30's pack: ISO.OO MRP

.:. ORGATRIL Tab. Nuvista

Male Sex hormones: Androgens21

Lynestrenol Smg/tablet. 30's pack: 268.80 MRP

Male sex hormones (androgens) include:

MEDROXYPROGESTERONE73 .:. PERLUTEX Tab. Leo Pharmal Kapricorn Medroxyprogesterone acetate Smg/tablet. Ind: Menstrual irregularities and other disorders caused by inadequate endocrine secretion of the corpus luteum hormone, such as- i. functional uterine bleeding, ii. amenorrhoea and oligomenorrhoea, iii. infertility due to inadequate luteal phase, iv. endometriosis. CII; SIE; Warnings & Cautions: Please see above under the text of progesterone.

Dosage: Functional uterine bleeding: 5-10mg daily for 5-10 days commencing on the assumed or calculated 16-21st day of the cycle so as to complete treatment on the 26th day of the cycle. Treatment should be given for two consecutive cycles. When bleeding occurs from a poorly developed prolife-rative endometrium, conventional oestrogen therapy may be employed in conjunction with medroxyprogesterone acetae, in doses of 510mg for 10 days. Amenorhoea and Oligonaenorrhoea: S-10mg for 10 days starting from the assumed 16th day of the cycle. When indicated, oestrogen therapy should be given prior to Perlutex. Infertility due to inadequate luteal phase: 2.510mg daily from day 16 to day 25. Endometriosis: S-20mg daily for 3-6 months. Child: Not applicable 20's pack: 2 12.40 MRP

NORETHISTERONE58 NORETIDSTERONE: Tablet Norethisterone is a synthetic progesterone hormone. It is available as Smg tablet. Ind: Postponement of menstruation; dysmenrrhoea, menorrhagia and premenstrual syndrome; metropathia haemorrhagica; Polymenorrhoea; endometriosis. CII; SIE; Warnings; Cautions: Please see above


1. Testosterone & esters 2. Mesterolone 3. Methyltestosterone (not in use)

ANDROGEN2 1 ,26,33 TESTOSTERONE & ESTERS: Capsule/Gel! Injection Testosterone is the male hormone, indicated for replacement therapy in males for conditions associated with a deficiency or absence of endogenous testosterone. It is available in capsule, gel and injection form for oral, transdermal and parenteral administration. Ind: Testosterone is indicated for replacement therapy in males for conditions associated with a deficiency or absence of endogenous testosterone: 1. Primary hypogonadism (congenital of acquired) : Testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, orchiectomy, Klinefelter's syndrome, chemotherapy, or toxic damage from alcohol or heavy metals. These men usually have low serum testosterone levels and gonadotropins (FSH, LH) above the normal range. 2. Hypogonadotropic hypogonadism (congenital or acquired): Idiopathic gonadotropin or luteinizing hormone-releasing hormone (LHRH) deficiency or pituitary-hypothalamic injury from tumors, trauma, or radiation. These men have low testosterone serum levels but have gonadotropins in the normal or low range. (Symptoms of hypogonadism include: Inpotence, decreased sexual desire, fatigue and loss of energy, mood depression, regression of secondary . sexual characteristics, osteoporosis). 3 . Inoperable mammary carcinoma. CII: Testosterone is contraindicated in prostatic or mammary carcinoma in the male; nephrosis; hypercalcaemia; pregnancy & breast-feeding. Testosterone is not indicated for use in women and must not be used in women (except in . inoperable mammary carcinoma) SIE: Sodium retention with oedema; increase in

Ensures c l i n ical s uccess in varied gynaecolog ical conditions and bleedi ng d i sorders

Manufacturer:

GEDEON RICHTER LTD BUDAPEST, HUNGARY

4

For Details :

City Overseas Ltd;

Yakub South Center {4th Floor) 67/0 Dhanmondi, 1 56 Lake Circus

Kalabag Square

Cefaclor monohydrate 1 00mgllml: drop. 15m! bot: 125.00 M'RP ,

.:. NAVACEF Cap. Navana

Cefaclor monohydn . te 250mg

& 500mg/capsule

250mg x 20's pack: 420.00 IP 500mg x 1 2's pack: 480.00 IP

:. NAVACEF Susp. Navana

•

Cefaclor monohydrate 1 2 5 mgl5m!:suspension 1 00mi bot: 1 90.00 MRP

.:. NAVACEF Drop Navana

Cefaclor monohydrate 15ml bot: 1 25.00 IP

l.t5mgl 1 .25ml: drop.

.:. OTICLOR Cap. Incepta

Cefaclor monohydrate 250mg

elevations of AST (SGOT), ALT (SGPT), alkaline

have been reported more frequently in children

aminoglycoside antibiotics and cephalosporin

than in adults; signs and symptoms usually occur

antibiotics. Concomitant administration of

a few days after initiation of therapy and subside

probenecid doubles the AUC for cefprozil. The

within a few days after cessation of therapy. CNS

bioavaila,bility of the capsule formulation

dizziness, hyperactivity, headache, nervousness,

of cefprozil is not affected when administered 5

insomnia, confusion and somnolence have been.

minutes following an antacid .

reported rarely; all were rev"rsible.

Hematopoietic- decreased leukocyte count, eosinophilia. Renal- elevated BUN, serum creatirtine. Other- diaper rash and superinfection, genital pruritus and vaginitis. The following adverse events, regardless of established causal

& 500mg/capsule

250mg x 20's pack: 420.00 MRP 500mg x 1 2 ' s pack: 480.00 MRP

.:. OTICLOR Susp. Incepta Cefaclor monohydrate 125mgl5m!:suspension 1 00ml bot: 1 80.00 MRP

.:. OTICLOR Drop Incepta

Cefaclor monohydrate 100mgllm!: drop.

relationship to Cefprozil, have been rarely reported: Anaphylaxis, angioedema, colitis (including pseudomembranous colitis), erythema multifonne, fever, serum-sickness like reactions, Stevens-Johnson syndrome and

Pregnancy & lactation: Cefprozil is not expected to be harmful to the fetus. Still during pregnancy

1 5m! bot: 125.00 MRP

the drug should be used if it is clearly needed.

Dosage & admin: Cefprozil is administered orally. Infants & children (6 months - I2 years): Upper respiratory tract infections*: Otitis media, 15mglkg 12 hourly for 10 days; Acute sinusitis, 7.5mglkg or 15mglkg 12 hourly for 10 days, (for moderate to severe infections the higher dose should be used). Children (2 years - 12 years): Upper respiratory tract infections*: Pharyngitisffonsillitis , 7.5mglkg 12 hourly for 10 days.

500mg x 1 2's pack: 360.00 MRP

.:. SEFALOR Susp. Techno Drugs

Cefaclor monohydrate 125mg/5m!:suspension 1 00m! bot: 1 80.00 MRP

CEFPROZIL42,1 33 CEFPROZIL: Tablet/Suspension Cefprozil is a semi-synthetic broad-spectrum

.:. CEFOZIL Tab. Popular Cefprozil 250mg

& 500mgltablet

250mg x IO's pack: 300.00 MRP 500mg x 8's pack: 440.00 MRP

.:. CEFOZIL Susp. Popular

Cefprozil 125mg/5ml: suspension

�Oml bot: 230.00 MRP

.:. ZlLAPRO Susp. Beximco

Cefprozil 250mg15ml: suspension 50m! bot: 275.00 MRP

thrombocytopenia.

.:. SEFALOR Cap. Techno Drugs Cefaclor monohydrate 500mg/capsule

ANTIMICROBIAL DRUGS

CEFUROXIME2 1 ,47 CEFUROXIME: Tablet/Suspension/Injection Cefuroxime is a 'second generation' cephalosporim. 'Cefuroxine axetir is an ester of 'cefuroxime' but has the same antibacterial spectrum.

Ind: See under cefaclor; surgical prophylaxis; more active against influenza gonorrhoeae.

& Neisseria

CII; SIE; Caution: See above under Cefaclor. Does: By mouth '- 250mg twice daily, doubled in bronchitis and pneumo�ia. UTI, 125mg twice daily, doubled in pyeloneph ritis. Gonorrhoea, I gm as " a single dose.

QIMP-15 (178)

Child- over 5 years, 125 mg twice daily, if

.:. AXIM Susp. Aristopharma

.:. CEROX-A IMlIV Inj. ACI

necessary doubled in otitis media_

Cefuroxime axetil 1 2Smg/SmI: suspension

Cefuroxime (as sodium salt) 2S0mglvial &

By i.m. or i.v. injection or infusion, 750 mg


7S0mg/vial (powder for reconstitution): i.mli.v

every 6-8 hours; 1.5gm every 6-8 hours in

.:. AXIM IMlIV Inj. Aristopharma

injection

severe infections; single doses over 750 mg i.v.

Cefuroxime (as sodium salt) 7S0mglvial

2S0mg x I vial combipack: SS.OO IP

route only.

(powder for reconstitution): i.mli.v injection

7S0mg x 1 vial combipack: 12S .00 IP

Child, 30-100mg/kg daily in 3-4 divided doses

I vial pack: 12S. 00 MRP

(2-3 divided doses in neonates)

.:. CEBAC-A Tab. Seema Cefuroxime axetil 12Smgltablet (Lc).

2S0mg x 8's pack: 200.00 MRP

injection (divided between 2 sites).

1 2Smg x 8's pack: 1 20.00 MRP

SOOmg x 8's pack: 360.00 MRP

Surgical prophylaxis, 1.5 g by i.v. injection at

.:. CEFOBAC Tab. Popular

Gonorrhoea, 1.5gm as a single dose by i.m.

.:. CEROXIME Tab. Asiatic

& SOOmgitablet (Lc).

induction; may be supplemented with 750mg

Cefuroxime axetil 2S0mg

i.m. 8 & 16 hours later (abdominal, pelvic, and

2S0mg x 10's pack: 1 80.00 MRP

orthopaedic operations) or followed by 750 mg


i.m. every 8 hours for further 24-48 hours


& SOOmgltablet (f.c).

.:. CEROXIME Susp. Asiatic

Cefuroxime axetil 1 2SmglSml: suspension 70ml bot: 198.00 MRP

.:. CEXITIL Tab. Medicon

:. CEFOBAC 750 IMlIV Inj. Popular

•

Cefuroxime axetil SOOmg/tablet (Lc) . SOOmg x 8's pack: 300.00 MRP

(cardiac, pulmonary, oesophageal, and


vascular operations).


Meningitis- 3gm i.v. every 8 hours; Child, 200-

1 vial pack: 12S.00 MRP

Cefuroxime axetil 12SmglSmI: suspension

.:. CEXITIL Susp. Medicon

.:. CEFOBAC 1.5 IV Inj. Popular


to 100mg/kg daily after 3 days or on clinical

Cefuroxime (as sodium salt) l .Sgmlvial (powder

improvement; Neonate, 100mg/kg daily

for reconstitution): i.v injection

Cefuroxime axetil 2S0mg/tablet (Lc).

I vial pack: 200.00 MRP

2S0mg x 12's pack:

240mg/kg daily (in 3-4 divided doses) reduced

reduced to 50mg/kg daily.

SK·F

Maximum power, maximum killing

1.-

Cefuroxime axetil 12SmglSml: suspension 70ml bot: 1 8 1 .00 MRP Cefuroxime axetil 1 2Smg, 2S0mg

&

SOOmgitablet (Lc). 12Smg x 20's pack: 300.00 MRP 2S0mg x 20's pack: SOO.OO MRP SOOmg x 12's pack: S40.00 MRP

:. AXET Susp. Orion

Cefuroxime axetil 1 2SmglSml: suspension 70ml bot: 2 1 S .00 MRP

:. AXET IMlIV Inj. Orion

•

&

7S0mg/vial (powder for reconstitution):i.mli.v injection 2S0mg vial x I's pack: 60.00 MRP 7S0mg vial x I's pack: 12S .00 MRP Cefuroxime axetil 1 2Smg, 2S0mg

&

SOOmgltablet (Lc). 1 2Smg x 12's pack: 1 44.00 MRP 2S0mg x 8's pack: 176.00 MRP SOOmg x 8's pack: 320.00 MRP Cefuroxime axetil 12SmglSml: suspension


SOOmg/tablet (Lc). 1 2Smg x IO's pack: ISO.OO MRP 2S0mg x 20's pack: SOO.OO MRP SOOmg x IO's pack: 4S0.00 MRP

.:. FAMICEF Susp. Acme

2S0mg x 20's pack: SOO.OO MRP

Cefuroxime axetil 1 2SmglSml: suspension


70ml bot: 1 9 8.00 MRP

.:. CEFOTIL Susp. Square

Cefuroxime axetil 2S0mglSml: suspension


(double strength)

Cefuroxime (as sodium salt) 7S0mg/vial (powder for reconstitution): i.mli.v injection

3Sml bot: 18S .00 MRP

.:. FAMICEF Inj. Acme

Cefuroxime (as sodium salt) 7S0mg/vial

7S0mg vial x l's pack: 1 2 5.00 MRP

(powder for rec;onstitution): i.mli.v injection

.:. CEFOTIL 1.5 IV Inj. Square Cefuroxime (as sodium salt) 1.5gmlvial (powder

7S0mg l\ 1 vial pack: 1 20.00 MRP



I .Sgm vial x I's pack: 200.00 MRP

2S0mg x 20's pack: SOO.OO MRP

.:. CEFROXIL 250 Tab. Hallmark



Cefuroxime axetil 12SmglSml: suspension

.:. CEFROXIL Susp. Hallmark


70ml bot: 1 9S.00 MRP

Cefuroxime (as sodium salt) 2S0mg

.:. CEFU-M Inj. Medimet Cefuroxime (as sodium salt) 7S0mg/vial

7S0mg/vial (powder for reconstitution):i.mli.v

.:. 'FUREX Tab. Drug Inter.

& SOOmgltablet (Lc).

.:. FUREX Susp. Drug Inter.

.:. FUREX Inj. Drug Inter.

2S0mg x 1 vial pack: SO.OO MRP

7S0mg vial x l 's pack: 12S.00 MRP

7S0mg x 1 vial pack: 1 2 S.00 MRP

.:. CEFURIM Tab. Somatec


& SOOmgltablet (Lc).

.:. FUROCEF Tab. Renata

Cefuroxime axetil 1 2Smg, 2S0mg


12Smg x 10's pack: ISO.OO MRP

.:. CEFURIM Susp. Somatec Cefuroxime axetil 1 2Smg/Sml: suspension



&

SOOmg/tablet (Lc).


.:. CEROX-A Tab. ACI

&

injection


SOOmg x 1 2's pack: S40.00 MRP

:. FUROCEF Susp. Renata

.


&

SOOmgltablet (Lc).

&

.:. FAMICEF DS Susp. Acme

Cefuroxime axetil 12SmglSmI: suspension

70ml bot: 1 90.00 MRP

.:. AXETIL Susp. Alco Pharma

.:. AXIM Tab. Aristopharma Cefuroxime axetil 1 2Smg, 2S0mg

100mi bot:

1 2Smg x 20's pack: 300.00 MRP

Cefuroxime axetil 125mglSml: suspension


.:. ELIROXIME Susp. Elixir

Cefuroxime axetil 1 2SmglSmI: suspension

SOOmg/tablet (Lc).

Cefuroxime axetil 2S0mgltabiet (Lc).

•

.:. AXETIL Tab. Alco Pharma

&

.:. CEFOTIL 750 IMlIV Inj. Square

.:. ADROX Susp. Ad-din

.:. AXET Tab. Orion

.:. CEFOTIL Tab. Square Cefuroxime axetil 1 2Smg, 2S0mg

.:. ELIROXIME Tab. Elixir


.:. FUROCEF IMlIV Inj. Renata

&

1 2Smg x IO's pack: I S0.00 MRP



7S0mg/vial (powder for reconstitution): i.mli.v

SOOmg x 8's pack: 360.00 IP

injection

.:. CEROXcA Susp. ACI Cefuroxime axetil 1 2SmglSml: suspension

7S0mg x 1 vial pack: 1 2 S.00 MRP

70ml bot: 198.00 IP

":' FUROCEF IV Inj. Renata

2S0mg x I vial pack: SS.OO MRP

QIMP-lS (179)

Cefuroxime (as sodium salt) I .Sgmlvial (powder

.:. MEXTIL Susp. Bio-pharma


Cefuroxime axetil 1 2Smg/Sml: suspension

I .Sgm x I vial pack: 230.00 MRP

70m! bot: 200.00 MRP

.:. FUROTEC-500 Tab_ A_P_C Pharma

.:. MEXTIL DS Susp_ Bio-pharma

Cefuroxime axetil SOOmgltablet (f.e).

Cefuroxime axeti1 2S0mg/Sml: suspension


(double strength)

.:. KILBAC Tab_ Incepta

Cefuroxime axelil 1 2Smg, 2S0mg

.:. SEFUR LV Inj_ Opsonin

SOm! bot: 250.00 MRP

&

.:. PRIMOCEF Tab_ Novo Healthcare

& SOOmgltablet (f.e).

SOOmgltablet (f.e).


12Smg x 20's pack: 300.00 MRP





.:. PRIMOCEF Susp_ Novo Healthcare Cefuroxime axetil 1 25mglSml: suspension

.:. KILBAC Susp_ Incepta Cefuroxime axetil 12SmglSm!: suspension 70ml bot: 198.00 MRP

.:. PROBAC Tab. Silva

& SOOmgitab1et (f.e).


(double strength)


&

7S0mglvial (powder for reconstitution): i.mli.Y injection

:. KILBAC IV Inj. Incepta Cefuroxime (as sodium salt) I .Sgmlvial (powder .



&

12Smg x 8's pack: 1 20.00 MRP 2S0mg x 12's pack: 300.00 MRP


12Smg x 14's pack: 1 80.00 MRP

(powder for reeonstitution):i.mli.Y injection

2S0mg x 1 4's pack: 350.00 MRP SOOmg x 7's pack: 3 1 5 .00 MRP

7S0mg vial x l 's pack: 1 25.00 MRP

.:. KILMAX Susp_ SK+F Cefuroxime axetil 1 2SmglSm!: suspension



.:. KILMAX Inj_ SK+F Cefuroxime (as sodium salt) 2S0mg/vial

&

7S0mg/vial (powder for reconstitution): i.mli.v injection 2S0mg x 1 vial pack: 55.00 MRP 7S0mg x I vial pack: 125.00 MRP

.:. LEPATH Tab_ Amico Cefuroxime axetil 2S0mg/tablet (f.e). 2S0mg x IO's pack: 220.00 MRP

.:. LIBOTIL Susp_ Libra

70ml bot: 198.00 IP

.:. MENAT Tab. Mystic

Cefuroxime axetif 12Smg

12Smg x 8's pack: 1 20.00 MRP

& SOOmg/tablet (f.e).

Cefuroxime axetil 1 2SmglSml: suspension 70ml bot: 1 70.00 MRP

.:. TIL Tab_ Apex Cefuroxime axetil 12Smg

& 2S0mg/tablet.

1 2Smg x 8's pack: 120.00 MRP 2S0mg x 8's pack: 200.00 MRP

.:. TIL Susp_ Apex


2S0mg x lO's pack: 300.00 MRP

Cefuroxime axetil 12Smg, 2S0mg


.:. XIMETIL Tab_ Globe


.:. ROFUROX Susp_ Radiant

250mg x 16's pack: 400.00 MRP

70m! bot: 250.00 MRP


.:. SEFATIL Tab_ Pacific

Cefuroxime axetil 12Smg, 2S0mg

.:. XIMETIL Inj_ Globe

& SOOmgl

tablet (f.c).

Cefuroxime (as sodium salt) 7S0mg/vial (powder for reconstitution): i.mli.Y injection I vial pack: 1 25.00 M�P


.:. XITIL Tab_ Ziska Cefuroxime axetil 250mgitablet.


\2S0mg x 14's pack: 350.00 MRP


.:. XITIL Susp_ Ziska


70ml bot: I S0.00 MRP Cefuroxime axetil 1 2Smg, 2S0mg

70ml bot: 1 90.00 MRP

&

.:. XTIL Tab. Syntho

.:. MENAT Susp. Mystic

SOOmgltab1et (f.c).

Cefuroxime axetil 2S0mgltablet.


1 2Smg x 12's pack: 1 80.00 MRP




.:. MEROCEF Tab. Ibn Sina


& SOOmg/tablet (f.e).


Cefuroxime axetil 1 25mglSml' suspension 70ml bot: 198.00 MRP

.:. MEXTIL Tab_ Bio-pharma

Cefuroxime axetil 12Smg, 2S0mg SOOmgltablet (f.e). 1 2Smg x 20's pack: 300.00, MRP

2S0mg x 20's pack: '500.00 MRP . SOOmg x 12's pack: 540.00 MRP


.:. SEFUR Susp_ Opsonin

(powder for reconstitution): i.mli.Y injection

70m! bot: 198.00 MRP

.:. MEROCEF Susp. Ibn Sina

&

.:. ZINACEF Inj_ GlaxoSmithKline

SOOmg x 6's pack: 270.00 MRP Cefuroxime axetil 1 2SmglSml: suspension


&

SOOmg/tablet (f.e).


.:. SEFUR Tab. Opsonin


I vial combipaek: 1 25.00 MRP

.:. STAXIM Tab_ Delta C.efuroxime axetil 2S0mg

70ml bot: 1 7 5.00 MRP

& SOOmgltablet (f.e).

.:. SEFATIL Susp_ Pacific

& 2S0mg/tablet (f.e).

.:. SEFUROX Inj. Sanofi-aventis


.:. ROFUROX Tab_ Radiant



.:. SEFUROX Susp. Sanofi-aventis

.:. STAXIM Susp. Delta

.:. RECOFAST IMlIV Illj. Rangs

SOOmg/tablet (f.e).

SOOmg x lO's pack: 450.00 MRP



70m! bot: 198.00 MRP

&

12Smg x lO's pack: 1 50.00 MRP


.:. RECOFAST Susp. Rangs Cefuroxime axetil 12SmglSml: suspension

I .Sgm x 1 vial eombipaek: 200.00 MRP

&

(powder for reconstitution): injection

.:. RECOFAST Tab. Rangs

SOOmgitablet (f.e).

7S0mg x I vial eombipaek: 1 25.00 MRP

.:. KILMAX Tab. SK+F

70m! bot: 198.00 MRP Cefuroxime axetil 1 2Smg, 2S0mg

2S0mg x I vial eombipaek: 55 .00 MRP

Cefuroxime axetil 12Smg, 2S0mg SOOmg/tablet (f.e).

70m! bot: 198.00 MRP

.:. PROBAC Susp. Silva

.:. KILBAC Inj_ Incepta

1 combipack: 200.00 MRP

Cefuroxime axetil 12Smg/Sml: suspension



I .Sgm vial x

2S0mg x lO's pack: 250.00 MRP

Cefuroxime axetil 2S0mglSml: suspension SOml bot: 250.00 MRP

for reconstitution): i. v injection

.:. SEFUROX Tab_ Sanofi-aventis

70ml bot: 1 98.00 MRP Cefuroxime axetil 2S0mg

.:. KILBAC DS Susp_ Incepta

Cefuroxime (as sodium salt) I .Sgmlvial (powder

.:. SEFUR DS Susp_ Opsonin

Cefuroxime axetil 2S0mg/Sml: suspension

I vial combipack: 250.00 MRP

.:. ZINNAT Tab. GlaxoSmithKline Cefuroxime axetil 1 2Smg, 2S0mg

(double strength)

125mg x 14's pack: 252.00 MRP

SOm! bot: 250.00 MRP


.:. SEFUR Inj. Opsonin

Cefuroxime (as sodium salt) 7S0mg/vial (powder

&

SOOmg/tablet.

500mg x 14's pack: 840.00 MRP

.:. ZINNAT Susp_ GlaxoSmithKline

for reconstitution): i.mli.v injection

Cefuroxime axetil 1 2Smg/Sml: suspension

I


vial eombipack: 125.00 MRP

' ANTJMJCROBIAL DRUGS

QIMP-15 (180)

..

hourly for 10 days; ii_ Acute exacerbation of

CEFDINIR: Capsule Cefdinir is a third generation semisynthetic cephalosporin antibiotic. It has a broad spectrum bactericidal activity against a wide range of

tablet for oral use.

days or 600mg once-daily for 10 days; iii_

Mode of action: Cefetamet as a cephalosporin

Acute maxillary sinusitis- 300mg 12 hourly for

antibiotic, it is bactericidal in action and kills

10 days or 600mg once-daily for 10 days; iv.

bacteria by interfering with bacterial cell wall

Pharyngitis/tonsillitis- 300mg 12 hourly for 5-

synthesis due to inhibition of transpeptidase

10 days or 600mg once-daily for 10 days; v_

enzyme. Cefetamet has excellent in vitro activity

Uncomplicated skin and skin structure

against the major respiratory pathogens

infections- 300mg 12 hourly for 10 days.

7mglkg 12 hourly for 10 days or 14mglkg

Streptococcus pneunoniae, Haemophilus influenzae, Moraxella catarrhalis and group A haemolytic streptococci. It is also active against lactamase- producing strains of H. influenzae and M. catarrhalis. Cefetamet has marked activity against Neisseria go.norrhoeae and possesses a

Pediatric patients (6 months through 12

common pathogens, including b-lactamase

years): i. Acute bacterial otitis media- 7mglkg

producing strains. Cefdinir has good stability to

12 hourly for 5-10 days or 14mglkg once-daily

bacterial b-lactamase and consequently is active

for 10 days; ii. Acute maxillary sinusitis-

against many ampicillin-resistant and arnoxycillin-resitant strains. Cefdinir is available as capsule of cefdinir INN 300mg and as dry powder suspension containing cefdinir INN I 25mg/5ml; 60ml bottle.

Mode of actiou: See above under the text of

once-daily for 10 days; iii. '

broad spectrum of activity against

Pharyngitis/tonsillitis- 7mglkg 12 hourly for 5-

Enterobacteriaceae.

10 days or 14mglkg once-daily for 10 days; iv.

Ind: Cefetamet pivoxil is indicated for the

Uncomplicated skin and skin structure

treatment of infections caused by sensitive ' microorganisms and in particular: 1 . Otolaryngeal

infections- 7mglkg 12 hourly for 10 days.

'cephalexin'.

Ind: Cefdinir is indicated for the treatment of- i. community acquired pneumonia, ii. acute

Cefdinir may be taken without regard to

infections : Otitis media, Sinusitis, Tonsillo

meals.

pharyngitis. 2. Infections of the lower respiratory

.:. ADINIR Cap. Acme

exacerbation of chronic bronchitis, iii. acute

Cefdinir INN 300mg/capsule

maxillary sinusitis, iv. pharyngitis, & tonsillitis, v. uncomplicated skin & skin structure infection.

300mg x 8's pack: 360.00 MRP

CII: Known hypersensitivity to the cephalosporin

•

group of antibiotics.

:. ADINIR Susp. Acme

Cefdinir INN 125mg/5ml: dry suspension 60ml bot: 1 75 .00 MRP

SIE: In clinical trials, most adverse events were

.:. CEDNlR Cap. SK+F

found mild and self-limiting; about 3% of

Cefdinir INN 300mglcapsule

patients discontinued medication due to adverse

300mg x 4's pack: 1 60.00 MRP

events thought to be due to cefdinir therapy, the

.:. CEDNIR DS Susp. SK+F

adverse effects were primarily gastrointestinal

Cefdinir INN 250mg/5ml: suspension (double

disturbances, usually diarrhea or nausea; about

strength)

0.4% patients discontinued the therapy due to

30ml bot: 1 60.00 MRP

administration.

.:. CEFIDA Cap. Beximco Cefdinir INN 300mglcapsule

antibiotics, prolonged treatment with cefdinir

300mg x 8's pack: 360.00 IP

may result in the possible emergence and

.:. CEFIDA Susp. Beximco Cefdinir INN 1 25mg/5ml: dry suspension

overgrowth of resistant organisms. Careful

tract: Tracheo-bronchitis, Bronchitis, Pneumonia. 3. Infections of the complicated & uncomplicated urinary tract: Acute pyelonephritis, Acute gonorrhea, Urethritis .

CII: Cefetamet is contraindicated in patients with hypersensitivity to cefetamet, any other cephalosporin or penicillins or any other ingredient of this formulation.

SIE: Most common gastrointestinal side effects may include- diarrhea, nausea & vomiting. Like other wider spectrum antibiotics, in the course of treatment with cefetamet internal colonization from difficult clostridium can be observed. In

rash, thought to be related to cefdinir

Precautions: As with other broad spectrum

cefetamet pivoxil hydrochloride 250mg & 500mg

chronic bronchitis- 300mg 12 hourly for 5-10

observation of the patient is essential. If

60ml bot: 1 50.00 IP

superinfection occurs during therapy, appropriate

.:. EFDINIR Cap. Iucepta

alternative antibiotic should be administered.

Cefdinir INN 300mglcapsule

As with other broad spectrum antibiotics, cefdinir

300mg x 8's pack: 360.00 MRP

should be prescribed with caution in individuals with a history of colitis.

.:. EFDINlR Susp. Incepta Cefdinir INN 1 25mg/5ml: dry suspension

In patients with transient or persistent renal


insufficiency (creatinine clearance Trl!�.!®

QIMP-lS (189)

.:. TRAXON I.V Inj_ Opsonin Ceftriaxone 250mg, 500mg Igm

& 2gmlvial with

.:. VERTEX I.V Inj. Orion Ceftriaxone 250mg, 500mg & Igm vial with

water: i.v injection


250mg vial with water: 90.00 MRP


500mg vial with water: 1 20.00 MRP


Igm vial with water: 1 60.00 MRP


MRP

2gm vial with water: 230.00 MRP

2gm vial with water: 300.00

.:. TRmAC I.M Inj. Globe Ceftriaxone 250mg, 500mg & Igm vial with 1 %

.:. WINNER I.M Inj_ Bio-pharma Ceftriaxone 250mg, 500mg, & Igm vial with 1 %

lidocaine: L m injection

lidocaine: i.m injection

250mg vial with lidocoine: 90.00 MRP


500mg vial with lidocaine: 1 20.00 MRP

500mg vial with lidocaine: 1 20.00 MRP

Igm vial with lidocaine: 160.00 MRP

Igm vial with lidocaine: 1 80.00 MRP

.:. TRIBAC I.V Inj. Globe Ceftriaxone 250mg, 500mg Igm

& 2gmlvial with

.:. WINNER I.V Inj. Bio-pharma Ceftriaxone 250mg, 500mg

&

I gm vial with


water: i. v injection








.:. XYLm I.M Inj. Libra

.:. TRIJECT I_M Inj. SK+F

Ceftriaxone 250mg, 500mg & Igm vial with 1 %

&

Ceftriaxone 250mg, 500mg

Igm vial with 1 %



250mg vial with lidocoine: 90.00 IP


500mg vial with lidocaine: 1 20.00 IP

500mg vial with lidocaine: 140.00 MRP

I gm vial with lidocaine: 1 60.00 IP

Igm vial with lidocaine: 190.00 MRP

.:. XYLm I.V Inj. Libra Ceftriaxone 250mg, 500mg

.:. TRIJECT I.V Inj. SK+F Ceftriaxone 250mg, 500mg & I gmlvial with

&

I gmlvial with


water: i. v injection

250mg vial with water: 90.00 IP

250mg vial with water: 1 00.00 MRP



Igm vial with water: 160.00 IP

Igm vial with water: 190.00 MRP

.:. TRIPHIN I.M Inj. Ziska

&

Ceftriaxone 250mg, 500mg

Igm vial with 1 %

Fourth generation

lidocaine: i . m injection 250mg vial with lidocoine: 80.00 MRP 500mg vial with lidocaine: \;0.00 MRP Igm vial with lidocaine: 160.00 MRP

.:. TRIPHIN I.V Inj. Ziska Ceftriaxone 250mg, 500mg & Igm vial with water: i.v injection 250mg vial with water: 80.00 MRP 500mg vial with water: 120.00 MRP Igm vial with water: 1 60.00 MRP 2gm vial with water: 250.00 MRP

.:. TRIZON I.M Inj. Acme Ceftriaxone 250mg, 500mg, & Igm vial with 1 %


250mg vial with lidocoine: 90.00 MRP 500mg vial with lidocaine: 120.00 MRP Igm vial with lidocaine: 1 60.00 MRP

.:. TRIZON I.V Inj. Acme Ceftriaxone 250mg, 500mg

&

Igm vial with

water: i.v injection 250mg vial with water: 90.00 MRP 500mg vial with water: 120.00 MRP Igm vial with water: 160.00

MRP

CEFEPIME26.62 CEFEPIME HCI: Injection Cefepime hydrochloride is a semi-synthetic fourth generation broad-spectrum cephalosporin antibiotic for parenteral administration. It is available as cefepime hydrochloride USP 500mg vial and Igm vial with I.-arginine sterile powder for i.m & i.v injection.

Mode of action: See above under the text of cephalosporins.

Ind: Cefepime is indicated in the treatment of the following infections: i. Pneumonia (moderate to severe); ii. Uncomplicated and complicated urinary tract infections (including pyelonephritis); iii. Uncomplicated skin and skin structure infections; iv. Complicated intra-abdominal infections; v, Empiric therapy for febrile neutropenic patients. Cefepime has been shown to be active against most strains of the gram-positive Staphylococcus

fix SWOUS"'1d D!fFJQlLT-TQ..'f.REAT h1f&1ions

other beta-Iactam antibiotics .

SIE: Generally cefepime is well tolerated. However, few side-effects including rash, pruritus, urticaria. fever, headache, nausea, vomiting, diarrhea, dizziness, oral moniliasis may occur.

Precautions: In patients with impaired renal function (creatinine clearance ?6Omllmin), the dose of cefepime should be adjusted. Cefepime should

be

advised with caution in individuals

with a history of gastrointestinal diseases, particularly colitis.

Pregnancy

.& lactation: There are no adequate

and well-controlled studies of cefepime use in pregnant women, so it should be used during pregnancy only if clearly needed. Cefepime is excreted in human breast milk in very low concentrations, so caution should be exercised if it is administered to a nursing woman.

Dosage & admin:

Recommended dosage schedule for adults with normal renal function: Moderate to severe pneumonia: Igm to 2gm i.v 12 hourly for 10 days;

Mild to moderate uncomplicated or complicated urinary tract infections (including pyelonephritis): O.Sgm to Igm tv or i.m 12 hourly for 7-10 days;

Severe uncomplicated or complicated urinary tract infections (including pyelonephritis): 2gm tv 12 hourly forlO days; .

Moderate to severe uncomplicated skin and skin structure infections: 2gm i.v 12 hourly for 10 days;

Complicated intra-abdominal infections: 2gm i.v 12 hourly for 7-10 days;

Empiric therapy for febrile neutropenic patients: 2gm i.v 8 hourly for 7 days; Septicaemia: 2gm i.v 12 hourly for 7-10 days. Pediatric patients (2 months up to 16 years; in weight up to 40kg): The maximum dose for pediatric patients should not exceed the recommended adult dose_

Pneumonia: SOmglkg i.v or i.m 12 hourly for 10 days;

Bacterial meningitis: SOmglkg i.v or i.m 8 hourly for 7-10 days;

Uncomplicated or complicated urinary tract infections (including pyelonephritis): SOmglkg i.v or i.m 12 hourly for 7-10 days;

and Streptococcus microorganisms and most of

.:. VERTEX I.M Inj. Orion Ceftriaxone 250mg, 500mg, .& I gm vial with 1 %

the gram-negative microorganisms, and also active against some of the anaerobes such as

lidocaine: L m injection

clostridium perfringens and mobiluncus spp.

8 hourly for 7 days;


CII: Cefepime is contraindicated in patients who

Impaired hepatic function:

500mg vial with lidocaine: 120.00 MRP

have shown hypersensitivity reactions to the

Igm vial with lidocaine: 1 60.00 MRP

cephalosporin class of antibiotics, penicillins or

�

-

�

-

Ceftriaxone

--

& any component of

the formulation.


TRIZON

SK+F

Uncomplicated skin & skin structure infectians: SOmglkg i_v or i_m 12 hourly for 10 days;

Febrile neutropenic patients: SOmglkg i.v or i.m No adjustment is necessary for patients with

impaired hepatic function.

ANTIMICROBIAL DRUGS

QIMP-15 (190)

Impaired renal function:

Cefepime hydrochloride 500mg

In patients with impaired renal function

water: i.mli. v injection.

moderate to severe infections in adult patients

(creatinine clearance ? 60mllmin), the dose of


with normal renal function:

cefepime should be adjusted_ The

Igm vial with water: 550.00. MRP

1. Complicated upper & lower urinary tract

recommended initial dose of cefepime should

.:. XIMEPIME IMIIV Inj. Globe

infections- Igm 12 hourly twice daily; 2. Skin

&

&

Igm vial with

be the same as in patients with normal renal


function except in patients undergoing

water: i.mli.v injection.

hemodialysis_


to 2gm 12 hourly twice daily;


4. Bacteremia/septicemia and severe

Drug inter: Renal fUnction should be monitored

Igm vial with

The following dosages are recommended for

& soft tissue infections- Igm 12 hourly twice

daily; 3. Lower respiratory tract infections- 1

carefully if high doses of aminoglycosides are to

infections- 2gm 12 hourly twice daily;

be administered with cefepime because of the

S. Infections in neutropenic patients- 2gm 12

increased pOlential of nephrotoxicity and ototoxicity of amino glycoside antibiotics. Nephrotoxicity has been reported following concomitant administration of other cephalosporins with potent diuretics such as

CEFPIROME42 CEFPIROME: I.V Injection Cefpirome is a fourth generation cephalosporin antibiotic that has an extended spectrum of

frusemide.

activity to include pseudomonas aeruginosa and

.:. CEFfIPIME lM/IV Inj_ Renata

sensitive staphylococcus aureus, coagulase


&

Igm vial with

gram-positive organisms including methicillin negative staphylococci and enterococcus faecal is.


Gefpirome is available as cefpirome sulphate


INN equivalent to 19m of cefpirome in vial for


intravenous injection.

.:. CEFfIPIME 2gm


IV Inj. Renata

Cefepime hydrochloride 2gm vial with water: i.v

cephalosporins.

injection.

Ind: I. Severe i!)fection, such as septicemia,

2gm vial with water: 1 1 00.00 MRP

bacteremia and infections in immunosuppressed

.:. EFEPIME lM/IV Inj. Ziska Cefepime hydrochloride 500mg & Igm vial with

neutropenic patients with hematological malignancies.

water: i.m/i.v injection.

2. Lower respiratory tract infections including


pneumonia.


3. Severe urinary tract infections including

•

pyelonephritis.

:. EFEPIME 2gm IV Inj. Ziska


4. Skin and soft tissue infections.

injection.

5. Bone and joint infections.

2gm vial with water: SOO.OO MRP

6. Infections in immunocompromised patients.

.:. GEN 4 IMIIV Inj. Ibn Sina

7. Other infections.


&

I grh vial with

water: i.mli.v injection.

Dose reduction is necessary in patients with markedly reduced renal function. After an initial dose of 0.S-2gm to establish a high serum concentration, the dose should be reduced by SO% for clearances of 49-21ml in min-l or 75% for clearances of 20mlin min-I. In end-stage renal disease, a supplementary dose equal to 50 % of the recommended daily dose .should be administered after each hemodialysis treatment. The duration of treatment depends on the patient's clinical and bacteriological response. Drug inter: There are no significant drug interactions have been observed with cefpirome. Storage: Cefpirome vial should be stored below 25°C protected from light. Freshly reconstituted solution is always recommended. Reconstituted

solution can be stored for up to 6 hours at room

temperature and 24 hours in refrigerator (at 2SoC) when prepared in water for injection BP.

.:. FORCE Inj. Square Cefpirome sulphate INN equivalent to 19m of cefpirome in vial with water: i.v injection Igm vial with water: 400.00 MRP

CII: Known hypersensitivity to the cephalosporin group of antibiotics.


SIE: Cefpirome is generally well tolerated. There


are no predictable life threatening effects of

•

hourly twice daily.

Other beta-lactam Antibiotics CARBAPENEMS

.:. GEN 4 IV Inj. Ibn Sina

cefpirome. Adverse gastrointestinal reactions

Cefepime hydrochloride 2gm vial with water: i. v

include- diarrhea, nausea, vomiting,

injection.

pseudomembraneous colitis, abdominal pain,

Carbapenems: Carbapenem antibiotics belong to

2gm vial with water: 1 000.00 MRP

have been reported in 3.S6% of the patients ..

other beta-lactam antibiotics. The important

.:. PIME-4 IMlIV Inj. ACI

Superficial phlebitis, thrombophlebitis and

carbapenem antibiotics currently available for


&

Igm vial with

& Meropenem. & meropenem are active

infection site reaction have been noted in 2.31 %

therapeutic use are- Imipenem

water: i.mlL v injection.

of patients receiving intravenous cefpirome.

Both' of the imipenem


Precaution: There are no special precautions for

against an unusually broad spectrum 'of

I gm vial with water: 550.00 IP

its use in the elderly provided dosage is adjusted

pathogens, which include the majority of

.:. PIME-4 2gm IV Inj. ACI

accordingly to renal function.

clinically significant gram-positive and gram


Pregnancy

injection.

has not been established in pregnancy and as

2gm vial with water: 1 1 00.00 IP

with all agents it should be administered with

activity makes these antibiotics particularly

.:. ULTRAPIME Inj. Incepta

caution, specially during the early months of

useful in the treatment of polymicrobic mixed


&

Igm vial with

& lactation: The safety of cefpirome

negative, aerobic and anaerobic strains of bacteria. This .broad spectrum antibacterial

pregnancy. As cefpirome is excreted in human

infections, as well as initial therapy prior to the


breast milk, either cefpirome treatment should be

identification of the causative organisms. The


discontinued or breast feeding ceased.

important difference in pharmacokinetics of these


Dosage & admin: Cefpirome is administered

two products is that, imipenem is inadivated in

.:. UNIPIM Inj. Drug Inter. Cefepime hydrochloride I gm vial with water:

only through the parenteral route. The dosage

the kidney by an enzymatic activity, -that is why,

is dependent upon the severity and site of

a specific'renal enzyme inhibitor- cilastatin is

i.mli. v iniection.

added with imipenem to make it stable to the


infection, the susceptibility of the infecting microorganisms and age, weight and renal

renal enzyme. But, unlike imipenem, meropenem


function of the patient. The drug is adminis

is not inactivated in the kidney by enzymatic

.:. XENIM Inj. Opsonin

tered through intravenous injection or infusion,

activity, so, meropenem is given without

QIMP.15 (191)

ANTIMICROBIAL DRUGS

& joint 7. Skin & soft tissue infections,

cilastatin.

Genitourinary tract infections, 6. Bone

Mode of action: Like other beat·lactam

infections,

antibiotics, carbapenems are also bactericidal and

8. Endocarditis.

should be reconstituted with the given solvent. It should be shaken until a clear solution is

act by interfering the synthesis of bacterial cell

CII: Patients with history of hypersensitivity to

wall.

carbapenems or other beta-Iactam antibiotics.

Ind: See below under the text of individual

SIE: Please consult the manufacturer's literature.

products.

Precautions: See under the text of carbapenems.

CII: Patients with history of hypersensitivity to

Pregnancy

& lactation: Safety in pregnancy and

obtained. Variations of colour from colourless

to yellow do not affect the potency of the

product. The reconstituted vial content should

then be diluted with the selected infusion

solutions. This combined product is chemically

incompatible with lacate & should not be

carbapenems or other beta·lactam antibiotics.

breast·feeding mothers not established.

SIE: See below under the text of individual

reconstituted in diluents containing lacate. But

Dosage & admin: The dosage

however, this product can be administered into

products

Precautions: If an allergic reaction to imipeneml meropenem occurs, the drug should be discontinued and appropriate measures to be taken. Monitor transaminase and bilirubin levels when used in hepatic disease. Monitor for over growth of non-susceptible organisms as with other antibiotics. Caution in individuals with a history of gastro-intestinal complaints, particularly colitis. In patients who develop diarrhoea, consider diagnosis of pseudomembranous colitis. Caution, if to be co administered with potentiany nephrotoxic drugs. Carbapenem therapy may reduce serum valploic acid levels, sub·therapeutic levels may occur. As with other antibiotics, caution may be required in using meropenem as monotherapy in critically ill patients with known or suspected Pseudomonas aeruginosa lower respiratory tract infection. Regular sensitiviry testing is recommended when treating Pseudomonas aeruginosa infection.

Pregnancy & lactation: Safety in pregnancy

and breast.feeding mothers not established. Dosage & admin: See below under the text of

individual products.

an i.v system through which a lacate solution

recommendations for imipenem + cilastatin

(for intravenous use only) represent the

is being infused. This combined product

enquivalent amount of cilastatin is also

to other antibiotics

quantity of imipenem to be administered. An

present. The total daily dosage of imipenem

Drug inter: Please ·consult manufacturer's

given in equally divided doses based on

Storage: Store the dry powder vial at room

bases on the type or severity of infection & is consideration of degree of susceptibility of the pathogens, renal function & body weight.

Adult dosage scheduleforpatients with normal renalfunction: Doses based lin a patient with normal renal

+ CILASTATIN 134

IMIPENEM + CILASTATIN: LV Injection lmipenem, chemically referred to as N forrnimidoyl thienamycin monohydrate, is a semi-synthetic derivative of thienamycin, the parent compound produced by the filamentous

literature. tempeture ( l5-250C).

Note: For further information, please consult manufacturer's literature.

.:. IMBAC SOO I.V Inj. Popular

lmipenem 500mg + cilastatin 500mglvial;

function (creatinine-clearance

>70mllminll.73m2) & a body weight >70kg. A reduction in doses must be made for a patient

with a creatinine clearance SOOmg should be

MEROPENEM: I.V Injection

<SOOmg should be given by i.v infusion over infused over 40·60 minutes. In patients who

develop nausea during the infusion, the rate

Meropenem, a carbapenem group, initially identified as olivanic acid, which is a beta

bacterium streptomyces catteleya. lmipenem is

of infusion may be slowed.

lactamase inhibitor. Meropenem as a beta·lactam

one of the widest spectrum of the beta-Iactam

PaediLltric dosing schedule (3 months or older):

antibiotic, its antibacterial spectrum (broad

antibiotics. It is active against nearly all common

For children & infants, the following schedule

spectrum) includes the majority of clinically

bacterial species, including those resistant to

is recommended: a) Children >40kg body

significant gram·positive

aminoglycosides and newer cephalosporins. As

weight should receive adult doses; b) Children

imipenem is inactivated in the kidney by an

and infants 2mgldl). Imipenem is not

equivalent

& 500mg of cilastatin equivalent as

white dry powder in vials.

recommended for the therapy of meningitis.

meningitis is suspected, an appropriate

If

Ind: The activity of imipenem against a widest

antibiotic should be used. Imipenem may be

spectrum of pethogens makes it p�icularly

used in children with sepsis as long as they are

& good tolerability at high doses, which makes it particularly useful for the treatment of meningitis

& other CNS infections.

Mode of action: Like other beat·lactam antibiotics, it is a bactericidal antibiotic and acts

not suspected of having meningitis.

by interfering the synthesis of bacterial cell wall.

aerobic/anaerobic infections as well as initial

Reconstitution of the injection viLli: Imipenem

Ind: Pneumonias including nosocomial

therapy prior to the identification of the causative

injection vial is supplied as a white sterile dry

pneumonias. Urinary tract infections. Intra·

useful in the treatment of polymicrobic mixed

organisms. Imipenem is used as empirical

powder containing SOOmg imipenem

abdominal infections. Gynaecological infections

monotherapy in intensive care unit (ICU) patients

equivalent & SOOmg cilastatin equivalent. This

combination is butTered with sodium

such as endometritis and pelvic inflammatory

with nosocomial infections. Imipenem is indicated for the treatment of the

bicarbonate to provide solutions in the pH

Meningitis. Septicaemia.

organisms: I . Intra-abdominal infections, 2.

change in pH when solutions are prepared &

infections in adult patients with febrile

Lower respiratory tract infections, 3.

used as directed. This combination contains 37.Smg of sodium (1.6mEq). The injection vial

. neutropenia used as monotherapy or in

Gynaecological infections, 4. Septicaemia, 5 .

following infections due to susceptible

range of 6.S to 8.S.There is no significant

disease. Skin and soft tissue infections. Besides, empiric treatment for presumed

combination with anti·viral or anti-fungal agents.

QIMP·15 (192)

ANTIMICROBIAL DRUGS There is no experience in paediatric patients with. neutropenia or primary or secondary immunodeficiency.

CII: Patients wit!) history of hypersensitivity to

carbapenems or other beta·lactam antibiotics.

intravenous bolus injection over approx. S minutes or by intravenous infusion (dilution in SO·200ml) over approx. IS to 30 minutes. Drug inter: Probenecid competes with

meropenem for active tubular secretion and thus

SIE: Meropenem i.v therapy is generally well

·inhibits the renal excretion, with the effect of

inflammation, thrombophlebitis, pain at the site

concentration of meropenem. As the potency and

tolerated. Local injection site reactions

increasing the elimination half·life and plasma

of injection. Skin reactions- rash, pruritus,

duration of action of meropenem dosed without probenecid are adequate, the co·administration

urticaria. Gastrointestinal- abdominal pain,

antibiotics, it is a bactericidal antibiotic and acts

by interfering the synthesis of bacterial cell wall.

Ind: Gram-negative infections including

Pseudomonas aeruginosa, Haemophilus

influenzae, N. meningitidis. It is also effective against N. gonorrhoeae.

Aztreonam should not be used alone for 'blind' treatment since it is not active against Gram· positive organisms.

CII: Aztreonam hypersensitivity. Pregnancy and

of probenecid with meropenem is not

breast·feeding.

eosinophilia, thrombocytopenia and neutropenia.

interaction data are available.

cramps; mouth ulcers, altered taste; jaundice and

Positive Coombs test. Reduction in partial

.:. ARONEM I.V Inj. ACI Meropenem trihydrate SOOmg & Igm vial;

hepatitis; blood disorders (including thrombo

thromboplastin time. Rarely systemic· allergic

angioedema and manifestations of anaphylaxis.

500mg vial x I's pack: 650.0 I IP

antibiotics; hepatic impairment; reduce dose in

nausea, vomiting, diarrhoea, pseudomembranous colitis. Blood· reversible thrombocythaemia,

rec'ommended. However, no specific drug

SIE: Nausea, vomiting, diarrhoea, abdominal

cytopenia and neutropenia); urticaria and rashes.

reactions (hypersensitivity), which may include·

powder for reconstitution: i. v injection.

Cautions: Hypersensitivity to beta·lactam

Liver function- reversible increases in serum

19m vial x I's pack: 1 200.00 IP

renal impairment. Dose: By Lm injection or i.v injection or

bilirubin, transaminases, alkaline phosphatase & lactic dehydrogenase. CNS· headache,

.:. I·PENAM I.V Inj. Incepta

Meropenem trihydrate SOOmg & Igm vial; powder for reconstitution: i. v injection.

paraesthesia and infrequently convulsions

infusion, Igm every 8 hours or 2gm every 12 hours; 2gm every 6·8 hours for severe

(although no casual relationship has been

SOOmg vial x I's pack: 700.00 MRP

infections (including systemic Pseudomonas

established). Other· oral and vaginal candidosis.

Igm vial x I's pack: 1 300.00 MRP

Precautions: See under the text of carbapenems.

fibrosis); single doses over 19m i.v route only.

Pregnancy & Lactation: Safety in pregnancy

.:. MEROBAC I.V Inj. Popular Meropenem trihydrate SOOmg & Igm vial;

Dosage & Admin: Adults: The dosage and

SOOmg vial x I's pack: 99S.00 MRP

depending on the type and severity of

.:. MEROM I.V Inj. Techno DrugS Meropenem trihydrate SOOmg & I gm vial;

and breast·feeding mothers not established. duration of therapy should

be established

powder for reconstitution: i. v· injection.· Igm vial x l's pack: 19S0.00 MRP

infection and the condition of the patient. The recommended daily dosage is as follows: Pneumonia, urinary tract infections, gynaecological infections such as endometritis, skin and skin structure infections· SOOmg i.v every 8 hours. Nosocomial pneumonias, peritonitis, presumed infections in neutropenic patients and septicaemia. 19m i.v every 8 hours. Meningitis· 2gm i.v every 8 hours. necessary in patients with hepatic insufficiency. Elderly patients: No dosage adjustment is required for the elderly with normal renal function or creatinine clearance values above SOmllmin. Renal impairment: Dosage should be reduced in patients with creatinine clearance less than Slmllmin, as scheduled below.

(mUrnin)

(based on unit doses

26·50 10 · 25 < 10

One unit dose

One-half unit dose

Meropenem trihydrate SOOmg & Igm vial; powder for reconstitution: i. v injection. Igm vial x I's pack: 19S0.00 MRP .:. RONEM I.V Inj. Opsonin Meropenem trihydrate SOOmg & Igm vial;

One-half unit dose

Every Every

12 hours 12 hours

24 hours

Children: 0·3 months· not recommended; 3 months·12 years· 10·20mglkg tv every 8 hours depending on type and severity of infection, susceptibility of the pathogens and the condition of the patient. Children over SOkg Meningitis. 40mglkg i. v every 8 hours. There renal impairment. Administration: Following reconstitution (Sml per 250mg) meropenem should be given as an

Specbac®

Meropenem

SOOmg vial: 261 .99 MRP Igm vial: 409.96 MRP

1.3 Tetracycline Group of Drugs TETRACYCLINE21.33

Igm vial x l's pack: 19S0.00 MRP

TETRACYCLINE: Capsule! Syrup/ Injection


.:. ROPENEM I.V Inj. Drug Inter.

Meropenem trihydrate SOOmg & Igm vial; powder for reconstitution: i. v injection.

Ind: Broad spectrum antibiotic i. e. infections

due to gram+ve and gram-ve bacteria, brucella,

chlamydia, mycoplasma, rickettsiae, spirochetes & large viruses; severe acne vulgaris, resistant malaria.

CII: Hypersensitivity to any tetracycline; renal

failure; pregnancy; infants & young children

powder for recol)stitution: i. v injection.

under 12 yrs. of age; SLE.

19m vial x I's pack: 19S0.00 MRP

overgrowth of commensal organisms,


Monobactams AZTREONAM21.51

SIE: G/lStro-intestinal tract discomforts;

superinfection with resistant organisms; staining of bone & teeth; rarely allergic reactions; nausea, vomiting, diarrhoea.

Cautions: Incompatible with penicillins & other

bactericidal antimicrobial agents; renal

impairment; pregnancy & childhood.

Dosage & admin: By mouth, 2S0·S00mg every

weight. adult dosage. is no experience in children with hepatic or

Gonorrhoea/cystitis, by i.m injection, 19m as

powder for reconstitution: i. v injection.

Meropenem trihydrate SOOmg & Igm vial; Every

SOmglkg every 6·8 hours; max. 8gm daily. Urinary.tract infections, O.S·lgm every 8·12 hrs.

.:. AZACTAM Inj. SquibblKapricorn Aztreonam SOOmg & I gmlvial: injection

.:. SPECBAC I.V Inj. Square

of SOOmg, Igm, 2gm)

infections; for child of 2 years or older to

19m vial x I's pack: 1 800.00 MRP

.:. MEROPEN I.V Inj. Renata

SOOmg vial x I's pack: 1 000.00 MRP

Frequency

30mglkg every 6·8 hours increased in severe

a single dose.

500mg vial x I's pack: 9S0.00 MRP

Igm vial x I's pack: 1 800.00 MRP Oose

Creatinine clearance

Child· over 1 week, by i.v injection or infusion,

powder for reconstitution: i.v injection.


Hepatic impairment: No dosage adjustment is

aeruginosa and lung infections in cystic

AZTREONAM: I.MII.V Injection

It is a mono.cyclic beta-Iactam (monobactam)

antibiotic with an antibacterial spectrum limited to gm·negative aerobic bacteria.

Mode of action: Like other beat·lactam

IV lnjection

6 hrs; By i.m. inj, 100·200mg every 6·8 hrs; By i. v. infusion, SOOmg every 12 hrs. Early Syphilis, SOOmg every 6 hrs. for IS days. Non gonococcal urethritis, SOOmg every 6 hours for 7·21 days.

QIMP·15 (193)

.:. A-TETRA Cap. Acme

Tetracycline SOOmg/capsule 100's pack: 228.00 MRP

.:. A-TETRA Tab. Acme

Tetracycline SOOmgltablet

mg ( I cap) daily (twice in severe infections


:. TETRAMYCIN Cap. Asiatic

•

Tetracycline 2S0mg/capsule 100's pack: 1 30.00 MRP

.:. TETRASINA Cap. Ibn Sina

& SOOmg/capsule

100's pack: 1 66.00 MRP

Tetracycline 2S0mg

.:. BACTOCYCUNE Cap. Medicon

2S0mg x 100's pack: 1 26.00 MRP

Tetracycline 2S0mglcapsule 100's pack: 1 30.00 MRP

.:. BPTETRA Cap. Bristol Tetracycline 2S0mglcapsule 1 00's pack: 100.00 MRP

SOOmg x SO's pack: 9 1 .00 MRP

.:. TETRAX Cap. Square

Tetracycline SOOmg/capsule SOOmg x 100's pack: 228.00 MRP

.:. TETRAZEN Cap. Zenith

.:. CAPTA Cap. Chemico

Tetracycline 2S0mglcapsule



100's pack: 100.00 MRP

.:. TITACIN Cap. Supreme

.:. G·TETRACYCLINE Cap. Gonoshas.

Tetracycline 250mg

& SOOmglcapsule

Tetracycline 2S0mg/capsule

2S0mg x 100's pack: 1 30.00 MRP

100's pack: 1 2 1 .00 MRP


.:. JMYCIN Cap. Jayson

Tetracycline 2S0mg/capsule 100's: pack: 1 30.00 MRP

.:. OMNIMYCIN Cap. Desh Pharma

Tetracycline SOOmg/capsule 100's pack: 2 1 S .00 MRP

.:. RANDAMYCIN Cap. Desh

Tetracycline 2S0mglcapsule. 60's pack: 72.00 MRP

.:. TETCLIN Cap. Pacific Tetracycline 2S0mglcapsule 100's pack: 1 00.00 MRP

.:. TETRACLINE Cap. Seema

Tetracycline 2S0mglcapsule 100's pack: 1 26.00 MRP

:. TETRACYCUNE Cap. A.P.C Pharma

•

Tetracycline 2S0mg/capsule 100's pack: 1 00.00 MRP

.:. TETRACYCUNE Cap. Elixir

Tetracycline 2S0mg

& SOOmglcapsule

2S0mg x 1 00's pack: SOOmg x l OO's pack:

.:. TETRACYCLINE Cap. Pharmadesh

Tetracycline 2SOmglcapsule 100's pack: 100.00 MRP

.:. TETRACYCLINE Cap. Skylab

Tetracycline 2SOmglcapsule 100's pack: 7S.00 MRP

.:. TETRACYCUNE-H Cap_ Hudson

Tetracycline 2S0mglcapsule 100's pack: 100.00 MRP

.:. TETRACYN Cap. Renata

Tetracycline 2S0mg

& SOOmglcapsule

2S0mg x 100's pack: 1 22.00 MRP SOOmg x 100's pack: 202.00 MRP

.:. TETRAGEN Cap. General Tetracycline 2S0mglcapsule 100's pack: 1 3S.00 MRP

lOO's pack: 100.00 MRP


.:. TETRAM Cap. Modern

Tetracycline 2S0mglcapsule l OO's pack: 132.00 MRP

:. TETRAMET Cap. Medimet Tetracycline 2S0mglcapsule •

1 00's pack: 1 32.00 MRP

.:. TETRAMIN Cap. Aexim Tetracycline 2S0mglcapsule

UTI) .

.:. APDOX Cap. Apex

Doxycycline 100mg/capsule 100's pack: 12S .00 MRP

.:. ASmOX Cap. Asiatic

Doxycycline 100mglcapsule 100's pack: 200.00 MRP

.:. BPDOX Cap. Bristol Doxycycline 100mg/capsule 100's pack: IS0.00 MRP

.:. COSDOX Cap. Cosmo Pharma

Doxycycline 100mg/capsule 100's pack: 200.00 MRP

.:. DELACIN Cap. Aexim Doxycycline 100mglcapsule 100's pack: 100.00 MRP

OXYTETRACYCLINE' I .33 OXYTETRACYCUNE: Capsule!

.:. DOXA·100 Cap. Apollo

Syrup/Injection Ind: Broad spectrum antibiotic i. e. infections due to gram+ve and gram-ve bacteria, brucella, chlamydia, mycoplasma, rickettsiae, spirochetes

& large viruses; severe acne vulgaris, resistant malaria.

CII; SIE; Caution: See above under tetracycline. Dosage & admin: By mouth, 250·500 mg every 6 hours. BY i. m injection, 100 mg every 8-12 hours. By slow i. v injection, 250-500 mg every 12 hours.

100's pack: 200.00 MRP Doxycycline 100mglcapsule SO's pack: 1 0 1 .00 IP 1 00's pack: 202.00 IP

.:. DOXACIL Cap. Square


.:. DOXACIN Cap. Desh Phar rna

Doxycycline 100mg/capsule 100's pack: 2 1 S .00 MRP

.:. DOXCUNE Cap. Alco Pharma


.:. CHEMOMYCIN Cap. Salton Oxytetracycline 250mg/capsule

Doxycycline SOmg

100's pack: 1 1 0.00 MRP

SOmg x SO's pack: 7 1 .00 MRP

.:. DOXICAP Cap. Renata

&

100mg/capsule

.:. ORAMYCIN Cap. Desh Pharma

1 00mg x 1 00's pack: 2 19.00 MRP

2SOmg x 60's pack: 72.00 MRP

.:. DOXICEN Cap. CPL Doxycycline 100mg/capsule

Oxytetracycline 2S0mg

& SOOmglcapsule

SOOmg x lOO's pack: 2 IS.00 MRP

100's pack: 200.00 MRP

.:. OXACIN Cap. Doctor's

.:. DOXYCIN Cap. Cosmic

Oxytetracycline 2S0mglcapsule

Doxycycline 100mg/capsule

100's pack: 85.00 MRP

100's pack: 2 10.00 MRP

.:. OXECYUN Cap. Acme

.:. DOXICLINE Cap. Ziska

Oxytetracycline 2S0mglcapsule

Doxycycline 100mglcapsuie

100's pack: 1 22.00 MRP

100's pack: 200.00 MRP

.:. OXYTETRACYCLINE Cap. Elixir

.:. DOXICO Cap. Supreme

Oxytetracycline 2S0mg/capsule


100's box:

100's pack: 2 1S .00 MRP

.:. RENAMYCIN Cap. Renata

Oxytetracycline 2S0mg/capsule

.:. DOXICON Cap. Medicon Doxycycline 100mg/capsule

100's pack: . 1 22.00 MRP .:. RENAMYCIN Inj. Renata

.:. DOXIGEN Cap. General

Oxytetracycline SOmglml: injection. I Oml vial: 1 6 . 1 2 MRP

DOXYCYCLINE21 .33

.:. TETRALIN Cap. Belsen


including chronic

Acne, SOmg daily for 6· 1 2 weeks or longer

.:. DOPAC Cap. Pacific Doxycycline 100mglcapsule

.:. TETRAICIN Cap. Ziska Tetracycline 2S0mglcapsule

ANTIMICROBIAL DRUGS

100's pack: 220.00 MRP Doxycycline 100mg/capsule 100's pack: 2 1 5 .00 MRP

.:. DOXIKEM Cap. Chemico Doxycycline 100mglcapsule 100's pack: 200.00 MRP

.:. DOXILIN Cap. Ambee

DOXYCYCLINE: CapsulelInjection Ind: Broad spectrum antibiotic i.e infections due

to gram+ve and gram-ve bacteria, brucella,

chlamydia, mycoplasma, rickettsiae, spirochetes

Doxycycline 100mglcapsule 100's pack: 2 12.00 MRP

.:. DOXIMET Cap. Medimet


& large viruses; severe acne vulgaris, resistant

1 00's pack: 220.00 MRP

malaria; and also chronic prostatitis and sinusitis .

.:. DOXIN Cap. Opsonin

CII; SIE & Caution: See above under


tetracycline, but ·may be used in renal

100's pack: 200.00 MRP

impairment; avoid in porphyria.

.:. DOXIPAN Cap. Salton

Dosage & admin: 200 mg on 1st day, then 100


QIMP-1S (194)

ANTIMICROBIAL DRUGS 100'5 pack: 200.00 MRP

-:- DOXISYN Cap. Syntho Doxycycline 1 00mglcapsuie 100'5 pack: 200.00 MRP

1_4 Aminoglycosides

Life-threatening infections and/or those caused by pseudomonas: The adult dose may be

Aminoglycosides that are used as bactericidal

shouldneither exceed l.Sgmlday nor be

iucreased to SOOmg every eight hours but

-:- DOXIZEN Cap. Zenith

antibiotics include2L

administered for a period longer than 10 day.

100'5 pack: 2 1 5 .00 MRP

Amikacin, Gentamicin, Kanamycin, Neomycin, Netilmicin, Tobramycin.

not be exceeded.


-:- DOX P Cap. Proteety


0

A maximum total adult dose of ISgm should

Urinary tract infections (other than pseudomonal infections): 7.Smg/kglday in two

100'5 pack: 128. 0 MRP

AMIKACIN52

-:- DOXSEEM Cap. Seema Doxycycline 100mg/capsuie

AMIKACIN: Injection

lnpaired renal function: In patient with

antibiotic.

be reduced andlor the intervals between doses

100'5 pack: 200.00 MRP

-:- DOXY-A Cap. Acme

Doxycycline l oomg/capsule 100'5 pack: 210.00 MRP

equally divided doses (equivalent to 2S0mg b.i.d in adulls).

Amikacin is a semi-synthetic aminoglycosidic

Ind: Amikacin is indicated in the short-tenn

treatment of serious infections. due to susceptible

impaired renal function the daily dose should ·increased to avoid accumulation of the drug.

Simple doses schedule for renal impairment is given below-

-:- DOXYLIN Cap. Skylab

strains of Gram-negative bacteria. It is effective

100's pack: 2 17.00,MRP

sepsis): in serious infections of the respiratory

Moderate impairment- SOOmg every 24 hours.

(including meningitis) and skin and soft tissue;

Administration: In most infections the

Doxycycline 100mg/capsuie

-:- DOXYSINA Cal" Ibn Sina

Doxycycline 100mglcapsuie . 100's pack: 202.00 IP

in bacterial septicemia (including neonatal tract, bones and joints, central nervous system

Mild impairment- SOOmg every 18 hours. Severe impairment- 2S0mg every

24 hours.

intra-abdominal infections (including peritonitis);

intramuscular route is preferred, but in life intramuscular injection route is not feasible

100's pack: 140.00 MRP

(including post-vascular surgery). Amikacin is

'also effective in serious complicated and

-:- E-DOXY Cap. Edruc Doxycycline 100mg/capsuie

recurrent urinary tract infections due to

Intraperitoneal use- Amikacin may be used as

100's pack: 200.00 MRP

may be considered as initial therapy in suspected

-:- DOXYSON Cap. Hudson

and in burns and post-operative infections

Doxycycline 100mg/capsuie

susceptible Gram-negative organisms. Amikacin

the intravenous route may be used. an irrigant after recovery from anaesthesia in concentration of 0.25 % .

Other route of administration: Amikacin in

-:- ELIDOX Cap. Elixir

Gram-negative infections

100's pack:

susceptibility. Amikacin is also e ffective in

satisfactorily as irrigation solution in abscess

Doxycyaline l oomglcapsule

Tobramycin resistant strains of Gram-negative

the cerebral ventricles.

-:- IMPEDOX Cap. ACI

effective in Staphylococcal infection and may be

100's pack: 2 1 5.00 MRP

condition in the treatment of known suspected


-:- FARDOX Cap. Pharmadesh 100's pack: 157.00 MRP

Doxycycline l oomg/capsuJe

-:- MARDOX Cap. Marksman

Doxycycline 100mg/capsuie 100's pack: 200.00 MRP

& therapy may be

threatening infections, or in patients in whom

started before obtaining the results of

infections caused by Gentamycin andlor

organisms. Amikacin has also been shown to be

considered as initial therapy under certain Staphylococcal disease such as, severe.infections

where the causative organism may either a Gram negative bacterium or Staphylococcus infection

-:- MEGADOX Cap. Beximco

due to susceptible strains of

100's pack: 2 1 5 .00 IP

certain severe infections such as neonatal sepsis.


-:- MONADOX Cap. Amico

Doxycycline 100mglcapsule

Staphylococcal/Gram-negative infections. In concomitant therapy with a penicillin type drug

may be indicated because ofthe possibility of

1 00'5 pack: 1 50.00 MRP

infections due to Gram-positive organism such as


CII: A history of hypersensitivity or serious toxic

-:- MYDOX Cap. Mystic 100's pack: 200.00 MRP

-:- ORIODOX Cap. Orion

Doxycycline 100mg/capsllie 1 00'5 pack: 2 10.00 MRP

-:- PEDOX Cap. A.P.C Pharma

Doxycycline 100mglcapsuie 100'5 pack: 150.00 MRP

-:- SUBRAMYCIN Cap. Gaco Doxycycline l oomg/capsule 50's pack: 103.44 MRP

-:- UNIDOX Cap. Globe

Streptococci or Pneumococci. reaction to aminoglycosides is contraindicated. Pregnancy

&

in pregnancy established.

lactation: The safety of Amikacin

& lactation has not yet been

SIE: When the recommended precautions

&

dosages are followed the incidence of toxic

reactions, such as tinnitus, vertigo, and partial

reversible or irreversible deafness, skin rash, .

drug fever, heada-che, paraesthesia, nausea and vomiting is low. Urinary signs of renal irritation,

azo-taemia and oliguria have been reported.

Dosage & admin: Adults & children:

-:- VIB Cap. Modern

(equivalent.to SOOmg bid, in adults). Use of the

100's pack: 200.00 MRP

children for the accurate measurement of the

-:- VIDOX Cap. Jayson

appropriate dose.

Doxycycline 1 00mg/capsuie

Doxycycline 100mg/capsuie 50's pack: 88.50 IP

-:- VITROCIN Cap. Nipa

Doxycycline 100mglcapsuie 100's pack: 200.00 MRP

cavities, the pleural space, the peritoneum and Overdose: In the event of overdose or toxic

reaction, peritoneal dialysis or haemodialysis will aid in the removal of Amikacin from the blood.

Phamaceufical precautions: Amikacin should be stored in a cool dry place, protected from light.

-:- AMIBAC Inj. Popular

Amikacin sulphate USP l oomgl2m1 ampoule 500mg/2m1 ampoule: Lm/i.v injection. 100mg (2m1) amp x IO's pack: 160.00 MRP

500mg (2m1) amp x 10's pack: 480.00 MRP

-:- CINAMAK Inj. Techno Drugs

Amikacin sulphate USP 2S0mgl2m1 ampoule

&

500mg/2ml ampoule: i.m/i.v injection. 250mg (2m1) amp x lO's pack: 120.00 MRP 500mg (2ml) amp x lO's pack: 2 10.00 MRP

-:- KACIN Inj. ACI

Amikacin sulphate USP 100mg/2ml ampoule

&

iOOmg (2ml) amp x lO's pack: 1 60.00 MRP

500mg (2m1) amp x IO's pack: 480.00 MRP

-:- PSUDONIL Inj. Drug Inter.

Amikacin sulphate USP 250mglampoule 250mg amp x 5's pack: 1 50.00 MRP

500mg amp x 5's pack: 225.00 MRP

GENTAMICIN21,33

100mgl2ml strength is recommended for

GENTAMICIN: InjectionIPowder

Neonates & premature children: An initial loading dose of 10mg/kg followed by ISmg/kglday in two equally divided doses.

Elderly: Doses should be adjusted under

&

500mg/ampoule: i.m/Lv injection.

ISmg/kglday in two equally divided doses

impaired renal function in elderly.

&

500mgl2m1 ampoule: i.m/i. v injection.

Doxycycline 100mg/capsuie 100's pack: 122.00 MRP

concentration of 0.25 % may be used

Ind: Septicaemia

& neonatal sepsis; meningitis

and other eNS infections; chest infections;

biliary tra,ct infections; acute pyelonephritis or prostatitis; endocarditis caused by Strep. viridens or faecalis (with a penicillin); wound infection

burns; gonorrhoea gram+ve

& persistant strains of both

& gram-ve organisms.

&

ANTIMICROBIAL DRUGS

QIMP.15 (195) CII: Hypersensitivity to gentamycin; pregnancy;

gentamicin

myasthenia gravis.

Dose: By i.m injection or by i.v injection over

pre-existing neurogenic disorder of the ear,

CII; SIE; Cautions: See under gentamicin

SIE: Nephrotoxicity, Ototoxicity.

3·5 minutes or by i.v infusion, 4.6mg/kg daily,

Cautions: Renal impairment, early pregnancy,

as a single daily does or in divided doses every

Dosage & admin: By i.m. or slow i.v. injection

mg/kg daily in divided doses every 8 hours

premature infants & neonates.

8 or 12 hours; in severe infections, up to 7.5

or infusion: severe infections, Smg/kg daily in

(reduced as Soon as clinically indicated,

divided doses at 6 or 8 hourly; other systemic

usually within 48 hours). Neonate up to 1

infections 2-Smg/kg daily at divided doses.

week, 3mg/kg every 12 hours. Infant over 1

In renal impairment the interval between

week 2.S·3mg/kg every 8 hours.

successive doses should be increased to 12

Child 2.2.Smg/kg every 8 hours.

hours when creatinine c1earence is 30·70

Urinary.tract infection, IS0mg as a single

mllmin. 24 hours for 10-30 mllmin.

48 hours

daily dose for 5 days. Gonorrhoea, 300n� as a

for 5-10 mlImin. 3-4 days after dialysis for less Gonorrhoea, 240 mg as a single dose. Child, up to 2 wks. 3 mg/kg 12 hourly; 2 wks to 12 yrs, 2 mg/kg every 8 hours.

200mg (2ml) amp x I 's pack: 846.48 MRP

.:. A·MYCIN DS Susp. Aristopharma

100ml bot: 60.00 MRP Erythromycin 250mg/5.mI: suspension

2·4 mg/kg daily by i. m injection in divided

STREPTOMYCIN: Streptomycin now a day

doses every 8 hours.

almost entirely reserved for the treatment of

tuberculosis so, this has been discussed under the

.:. EGEN Inj. Edruc

Gentamicin 80mg/2ml ampoule: injection

.:. GENACYN Inj. Square

.:. A·MYCIN Susp. Aristopharma

Erythromycin 1 25mg/5m1: suspension

STREPTOMYCIN

By intrathecal injection: 1 mg daily, with

group of anti·tubercular drugs.

�

5 amps pack: 47.50 MRP

250mg x 1 00's pack: 425.00 MRP

500mg x 50's pack: 400.00 MRP

single dose.

50mg (Iml) amp x I's pack: 309.59 MRP

than Smllmin.

.:. A·MYCIN Tab. Aristopharma

Erythromycin 250mg & 500mg/tablet

100ml bot: 103.00 MRP

.:. A·MYCIN Paediatric Susp. Aristopharma

Erythromycin 200mg/5ml: suspension 60ml bot: 60.00 MRP

.:. ARIGRAM Susp. CPL


.:. E-BAC Susp. Popular

j

1.5 Macrolides

Erythromycin 125mg/5m1: suspension

.:. GENACYN Paed. Inj. Square

Macrolides include-


Azithromycin, Clarithromycin, Erythromycin, Roxithromycin, Spiramycin.

.:. ECIN-DS Tab. Gaco Erythromycin 500mg/tablet.

Gentamicin 80mg/2ml ampoule: in ection 10 amps pack: 1 0 I . 10 MRP

Gentamicin 20mg/2m1 ampoule: injection

:. GENTABAC Inj. Popular

•

80mg (2ml) x 10 amps pack: 1 0 1 . 10 MRP

.:. GENTASOL Inj. Techno Drugs

ERYTHROMYCIN21,33 .

ERYTHROMYCIN: Tablet/Syrupl Injection

Ind: An alternative to penicillin in hypersensitive

Gentamicin 80mg/2ml ampoule: injection

patients (such as in streptococcal,


pneumococcal- as in resp. tract infections,

.:. GENTIN Inj. Opsonin Gentamicin suiph. 20mg & 80mg/2m1 ampoule:

staphylococcal, treponemal & gonorrhoeal

infections; sinusitis; an alternative to

injection

tetracycline, in mycoplasma pneumoniae

infection; also recommended for diphtheria,

20mg (2m1) x 25 amps: 150.00 MRP

pertusis and clostridial infections.

80mg (2ml) x 25 amps: 250.00 MRP

500mg x 28's pack: 224.08 MRP

.:. ECIN Susp. Gaco

.

Erythromycin 125mg/5ml: suspension

Gentamicin suiph. 20mg & 80mg/2ml ampOUle: injection

20mg (2ml) x 10 amps pack: 60.50 MRP

1 00ml bot: 56.00 IF


.:. EDRY Susp. Edruc

Erythromycin 1 25mg/5ml: suspension 100mi bot: 55.00 MRP

.:. E-LID Susp. Syntho

Erythromycin 1 25mg/5m1: suspension lOOml bot: 54.00 MRP

.:. EM-SOO Tab. Modern

Erythromycin 500mg/tablet 20's pack: 1 60.00 MRP

.:. EM Susp. Modern

.:. G-GENTAMICIN Inj. Gonoshas

CII: Pre·existing hepatic disorder; history of


injection

SIE: Nausea, vomiting, abdominal discomfort,

.:. EMYCIN Tab. Medimet

Gentamicin sulph. 40mg & 80mg/2m1 ampoule:

40mg (2m1) x 25 amps pack: 1 50.00 MRP

hypersensitivity.

diarrhoea (antibiotic·associated colitis reported);

1 00ml bot: 60.00 MRP Erythromycin 250mg/tablet.

urticaria, rashes and other allergic reactions;

50's pack: 243.00 MRP

Gentamicin suiph. 20mg & 80mg/2ml ampoule:

cholestatic jaundice and cardiac effects (including

Erythromycin 1 25mg/5ml: suspension


Cautions: Hepatic and renal impairment;

80mg (2m1) x 25 amps pack: 278.25 MRP

.:. INTAMYCIN Inj. Incepla

reversible hearing loss reported after large doses;

injection

chest pain and arrhythmias) repored.

80mg (2m1) x 10 amps pack: 1 00.00 MRP

prolongation of QT interval (ventricular

:. INVIGEN Inf. Beximco

•

tachycardia reported); porphyria; pregn-ancy (not

.:. EMYCIN Susp. Medimet 100mi bot: 60.94 MRP

.:. ERIXIN Susp. Amico


•

.:. ERIXIN Drop Amico

Gentamicin sulph. 80mg/I OOml (i.e 0.08% w/v):

known to be harmful) and breast feeding (only

100mi bot for i.v infusion: 47.03 MRP

Arrhythmias: avoid concomitant administration

60ml drop: 60.00 MRP

Dosage & admin: By mouth: Adult, 250-


i.v infusion.

small amounts in milk).

with astemizole, terfenadine or cisapride .

•:. OPTIMYCIN Inj. Aristopharma

Gentamicin sulph. 80mg/2m1 ampOUle: injection


SOOmg every 6 hours; serious infections, upto 4 gm daily, Child, upto 2 years 12Smg every 6 hours, 2-8 years 2S0mg every 6 hours.

NETILMICIN21,7 1

Acne, 250mg twice daily; maintenance, 2S0mg once daily•

•:. NETROMYCIN Inj. Schering Plough/Janala Health Care

Netilmicin sulphate 50mg/lml ampoule 200mg/2ml ampOUle: Injection

Early syphilis, SOOmg 4 times daily for 14

&

Ind: Serious gram-negative infections resistant to

days. By i.m or i.v. injection: Adult·l00 mg every 4 to 8 hours. 'Child-2S-S0 mg/kg body-wt. i.m or i.v daily in divided doses.

Erythromycin 200mg/5m1: drop

.:. ERMAC Susp. Opsonin 100ml bot: 56.64 MRP

.:. ERO Susp. Hudson

Erythromycin t 26mg/5ml: suspension 100ml bot:56.00 MRP

.:. EROCIN Tab. Acme

Erythromycin 250mg & 500mg/tablet 250mg x 50's pack: 242.00 MRP

500mg x 30's-pack: 258.00 MRP

.:. EROCIN SUsp. Acme

Erythromycin t25mg/5m1: suspension

\\

ANTIMICROBIAL DRUGS

QIMP-lS (196)

100ml bot: S6.64 MRP

.:. ERYCIN Susp. Somatec

100ml bot: S4.S0 MRP

.:. EROM Tab: Chemico

Erythromycin 12SmglSmI: suspension

.:. ETROCIN Tab. Beximco

Erythromycin 2SOmg

& SOOmgltablet

100m! bot: S6.00

MRP

Erythromycin 2S0mg

& SOOmgltablet

2S0mg x l OO's pack: 4SS.00 MRP

2S0mg x lOO's pack: 48S.Q() MRP

.:. ERYLIN Susp. Cosmic

sOOmg x SO's pack: 430.00 MRP


.:. EROM Susp_ Chemico


.:. ETROCIN Susp. Beximco

Erythromycin 12Smg/Sml: suspension

.:. ERYMEX Tab. Ibn Sina

Erythromycin 12Smg/SmI: suspension

lOOml bot: 60.00 MRP

Erythromycin SOOmgltablet

lOOml bot: 60. 1 8 MRP

.:. EROMAC Susp. General

30's pack: 240.00 MRP

.:. EURO Tab. Nipa Erythromycin 250mg

Erythromycin l 2SmglSmI: suspension

.:. ERYMEX Susp. Ibn Sinl\

100ml bot: 6 1 .00 MRP

Erythromycin 1 2SmglSmI: suspension

SOOmg x SO's pack: 430.00 MRP

& SOOmg/tablet


SOOmg x 30's pack: 22S.00MRP

.:. EROMED Susp. Aexim

100ml bot: SS.OO MRP


.:. ERYNET Susp. Bristol

.:. EURO Susp. Nipa

l OOml bot: SS.OO MRP



.:. EROMYCIN Tab. Square

100mi bot: 60.00 MRP

l OOml bot: 60.00 MRP

Erythromycin 2S0mg/tablet

.:. ERYPED Susp. UniHealth

.:. FIRMAC Tab. lncepta

SO's pack: 217.S0 MRP

Erythromycin 124mglSmI: suspension

Erythromycin 250mg


2S0mg x 50's pack: 22S.00 MRP

.:. EROMYCIN DS Tab. Square

& SOOmgltablet

SOOmg x 30's pack: 2S8.00 MRP


.:. ERYROX Tab. Navana

30's pack: 242.70 MRP


.:. FIRMAC Susp. lncepta

.:. EROMYCIN Susp. Square

30's pack: 240.00 MRP


Erythromycin l2SmglSmI: suspension

.:. ERYROX Susp. Navana


100m! bot: S6.64 MRP


.:. 1L0CIN Tab. Doctor's

.

.:. EROMYCIN Drop Square

1 00mi bot: 60.00 MRP

Erythromycin 500mgltablet

Erythromycin 200mglS ml: drop

.:. ERYSEEM-500 Tab. Seema

20's pack: 160.00 MRP

60ml drop: 60.00 MRP


.:. ILOCIN Susp. Doctor's

.:. ERONA 500 Tab. Delta

20's pack: 160.00 MRP



.:. ERYSEEM Snsp. Seema




.:. KUMUCIN Susp. Kumudini Erythromycin 12SmglSmI: suspension

.:. ERONA Susp. Delta

1 00ml bot: S6.00 MRP

Erythromycin l 2Smg/Sml: suspension

.:. ERYTH Susp. Marksman

100mi bot: SS.OO MRP



.:. MAC Susp. Orion

MRP

.:. ERONIX Susp. Ziska

100ml bot: SS.OO


.:. ERYTHIN Tab. ACI



.:. MAC DS Susp. Orion

.:. EROSA Tab. Bio-pharma

30's pack: 240.00 MRP

Erythromycin 250mgl5m1: suspension

.:. ERYTHIN Susp. ACI

70ml bot: 74.00 MRP

Erythromycin 2S0mg

& SOOmgltablet


Erythromycin 12Smgl5m1: suspension " l OOml bot: 60.00 MRP

Erythromycin 12SmglSml: suspension


100ml bot: 6 1 .06 MRP

.:. MACAS Tab. Asiatic

.:. EROSA Susp. Bio-pharma

.:. ERYTHRO 500 Tab. Medicon




24's pack: 192.00 MRP

SOOmg x SO's pack: 400.00 MRP



.:. MACAS Susp. Asiatic

.:. E-ROX 500 Tab. Desh Pharma

.:. ERYTHRO Susp. Medicon

Erythromycin 12S niglSmI: suspension

Erythromycin SOOmg/tablet


1 00ml bot: -56.00 MRP


100ml bot: S6.00 MRP

.:. MACERY Tab. Pacific

.:. E-ROX Susp. Desh Pharma

.:. ERYTHROMYCIN-A Susp. Ad-din

Erythromycin 250mg

Erythromycin l 2SmglSmI: suspension


250mg x 50's pack: 225.00 MRP



SOOmg x 30's pack: 246.00

.:. ERRIN Susp. Radiant

.:. ERYTHROX Tab. Renata Erythromycin 2S0mg & SOOmgitablet

.:. MACERY Susp. Pacific Erythromycin 12Smg/SmI: suspension.


2S0mg x SO's pack: 242.5.0 MRP


& 500mgltablet MRP


SOOmg x SO's pack: 429.S0 MRP

.:. MACIN Susp. HaDmark

Erythromycin 2S0mgltablet

.:. ERYTHROX Susp. Renata

Erythromycin 12S mglSmI: suspension




.:. ERY-500 Tab. Alco Pharma


.:- MACRO E Snsp. Proteety Erythromycin 125mgl5m1: suspension.

.:. ERY-250 Tab. Alco Pharma


.:. ERYZEN Tab. Zenith


Erythromycin 2S0mg

.:. ERY Susp. Alco Pharma

2S0ing x 60's pack: 261 .00

& SOOmgltablet MRP

SOOmg x 20's pack: 1 72.00 MRP

Erythromycin 12SmglSml: suspension 100ml bot: SO.OO MRP

.:. ERYZEN Susp. Zenith Erythromycin 12SmglSmI: suspension


.:.

MAKCIN Susp. Techno Drugs

Erythromycin 1 2SmglSmI: suspension. 100ml bot: 50.00 MRP

Erythromycin 2S0mgltablet

lOOml bot: .56.64 MRP

.:. MITROCIN Tab. MiDat Erythromycin 2S0mg & 500mgltablet


.:. ETHRO Susp. Pharmadesh Erythromycin 1 25mglSmI: suspension

SOOmg x 20's pack: 1 6 1 .20 MRP

.:. ERYBAC Tab. Drug Inter.

.:. ERYBAC Susp. Drug Inter.

250mg x 30's pack: 136.50 MRP


1 00ml bot: SS.OO MRP

1 00m! bot: SS.OO MRP .

.:. ETHROLEX 500 Tab. Mystic

.:. ERYCIN Tab. Somatec & SOOmgltablet



30's pack: 217.50 MRP

.:. MITROCIN DS Susp. Millat

.:. ETHROLEX Susp. Mystic

Erythromycin 250mgl5m1: suspension



Erythromycin 2S0mg

2S0mg x SO's pack: 2 1S.00 MRP


,

\

.:. MITROCIN Susp. Millat

Erythromycin I 25nigl5m1: suspension.

QIMP·15 (197) .:. MYCIN Tab. Ambee

ANTIMICROBIAL DRUGS

for 3 days. For sexually transmitted diseases

Erythromycin SOOmgltablet SOOmg x SO's pack: 400.00 MRP

like genital ulcer, non·gonococcal urethritis

.:. MYCIN Susp. Ambee

a single Igm (lOOOmg) dose. For the treatment

Erythromycin 12SmglSml: suspension. lOOml bot: 60.00 MRP :. PEDICIN Susp. Rangs

•

and cervicitis due to Chlamydia trachomatis: of urethritis and cervicitis due to Neisseria gonorrhoeae: a single 2gm (2000mg) dose. In typhoid, SOOmg on�e daily for 7 days. In

Erythromycin 12SmglSml: suspension. l OOml bot: 60.00 MRP

Shigellosis, SOOmg once on first day, followed

.:. PRIOCIN Tab. SK+F

by 2S0mg once daily for next 4 days.

Erythromycin SOOmgltablet SOOmg x 40's pack: 280.00 MRP .:. PRIOCIN Susp. SK+F

Cholera, a single Igm (1000mg) dose. In

Children: Over 6 months, 10mg/kg once daily for 3 days; or body·weight IS·2S kg, 200mg once daily for 3 days; body·weight 26·3S kg,

Erythromycin 12SmglSml: suspension. l00ml bot: 60.00 MRP

300mg once daily for 3 days; body·weight 36·

.:. RHYTHM Susp. Apex

Azithromycin tablet can be taken with or

4S kg, 400mg once daily for 3 days.

Erythromycin 12Smg/Sml: suspension. 100mi bot: S2.00 MRP

least I hour before or 2 hours after meal.

.:. THROCIN Tab. Globe

Injection:

Erythromycin 2SOmg & SOOmgltablet. 2S0mg x l00's: 430.00 MRP SOOmg x SO's: 400.00 MRP .:. THROCIN Susp. Globe

without food; suspension should be taken at

by oral therapy at a single, daily dose of SOOmg tablet to complete a 7 to IO·day course.

therapy should be followed by oral therapy at a single, daily dose of 2S0mg to complete a 7· day course. Children: Use of azithromycin by i.v route althugh not yet approved by the FDA, the i.v preparation has been studied in children using

AZITHROMYCIN21 .26.33 AZITHROMYCIN: Capsule! Suspension! Injection

Azithromycin is an azalide antibiotic, a subclass of macrolide antibiotic. Mode of action: Azithromycin acts by binding to the SOs ribosomal subunit of susceptible microorganisms and thus interfering with microbial protein synthesis. It is a broad· spectrum antibiotic and has been shown to be active against most strains of the following microorganisms. Gram·positive: Staphylococcus aureus, Streptococcus agalactiae, Streptococcus pneumoniae, Streptococcus pyogenes. Gram·negative: Haemophilus ducreyi, Haemophilus influenzae, Moraxella catarrhaJis, Neisseria gonorrhoeae, Escherichia coli. Others: Chlamydia pneumoniae, Chlamydia trachoma tis, Mycoplasma pneumoniae, Bacteroides fragilis, Legionella pneumophila, Toxoplasma gondii.

Respiratory tract infections; otitis media; skin and soft·tissue infections; non·gonococcal urethritis and cervicitis due to Chlamydia trachomatis; gonococcal urethritis and cervicitis due to Neisseria gonorrhoeae; Genital ulcer disease in men due to Haeinophilus ducreyi (chancroid); Cholera; Shigellosis; Typhoid. CII: Hepatic impairment. S/E; Cautions: See under erythromycin; mild neutropenia reported. ,I Pregnancy & lactation: Exercise caution in /' pregnancy & breast feeding. In.d:

a dose of 10mg/kg administered over 1 hour once daily. I.V therapy should be followed by oral therapy as desired, in accordance with clinical response.

Drug inter: Avoid concomitant administration with astemizole or terfenadine.

SK·F

11TH ROX®

Azithromycin tablet f powder for suspension

Short duration long action antibiotic

1-

.:. AZICIN Cap. Opsonin

Azithromycin 200mg/Sml: suspension. 20ml bot: 8S.00 MRP 3Sml bot: 130.00 MRP .:. AZILIT-SOO Tab. Desh Pharma

Azithromycin SOOmg/tablet 3's pack: 90.00 MRP

.:. AZILIT Susp. Desh Pharma

Azithromycin 200mglSml: suspension . ISml bot: 8S.00 MRP .:. AZIMETE Susp. Medimet

Azithromycin 200mglSml: suspension. ISml bot: 8S.00 MRP .:. AZIMEX Tab. Drug Inter.

Azithromycin 2S0mg & SOOmgltablet 2S0mg x 20's pack: 360.00 MRP SOOmg x 9's pack: 234.00 MRP .:. AZIMEX Susp. Drug Inter.

Azithromycin 200mglSml: suspension. I Sml bot: 8S.00 MRP 30ml bot: 120.00 MRP .:. AZIMON 500 Tab. MonicoPharma

Azithromycin USP SOOmgltablet 8's pack: 240.00 MRP .:. AZIN Cap. Acme

Azithromycin 2S0mg/capsule 6's pack: 1 20.00 MRP .:. AZIN Tab. Acme

.:. AR-SOO Tab. Ultra Pharma

Azithromycin SOOmgltablet 3's pack: 90.00 MRP

.:. ASIZITH Tab. Asiatic

Azithromycin 200mglSml: suspension. ISml bot: 8S.00 IP 30ml bot: 1 30.00 IP

.:. ASIZITH Susp. Asiatic

Azithromycin 2S0mg & SOOmgltablet 2S0mg x 6's pack: 96.00 MRP 500mg x 6's pack: 144.00 MRP

Azithromycin SOOmgltablet 3's pack: 90.00 MRP

Azithromycin 2S0mg & SOOmg/tablet 2S0mg x 6's pack: 120.00 MRP SOOmg x 6's pack: 1 80.00 MRP Azithromycin 200mglSml: suspension. ISm! bot: 8S.00 MRP .:. AVALON 500 Tab. Techno Drugs

Azithromycin USP SOOmg/tablet 6's pack: 1 80.00 MRP

.:. AVALON Susp. Techno Drugs

Azithromycin USP 200mglSml: suspension. ISm! bot: 8S.00 MR 30ml bot: 1 30.00 MRP .:. AVALON I.V Inj. Techno Drugs

respiratory tract infections, otitis media and

Azithromycin dihydrate USP SOOmg;Sm! vial (powder for reconstitution): i.v injection. SOOmg (Sml vial) x l 's pack: 240.00 MRP

skin & soft tissue infections: SOOmg once daily

.:. AZ-2S0 Cap. Aristopharma

Dosage & admin: By mouth: Adult: For

.:. AZALID Susp. Orion

Azithromycin 200mglSml: suspension. ISml bot: 8S.00 MRP 3Sm! bot: 1 30.00 MRP

.:. AZICIN Susp. Opsonin

least two days. I.V therapy should be followed

daily dose by i.v route for one or two days. I.V

Erythromycin 12Smg/Sml: suspension. 100ml bot: 61.07 MRP

.:. AZALID Cap. Orion

Azithromycin 2S0mg & SOOmglcapsule 2S0mg x 6's pack: 120.00 MRP SOOmg x 8's pack: 240.00 MRP

Adults: Community·acquired pneumonia:

.:. ZEROBAC Susp. Chemist

:. ZURACIN Susp. Rephco

.:. AZ Susp. Aristopharma

Azithromycin 200mglSml: suspension . 20m! bot: 9S.00 MRP

SOOmg as a single daily dose by i.v route for at

Pelvic inflammatory disease: SOOmg as a single

•

.:. AZ-SOO Cap. Aristopharma

Azithromycin SOOmglcapsule SOOmg x 6's pack: 1 80.00 MRP

Azithromycin 2S0mg & SOOmg/capsule 2S0mg x 6's pack: 1 20.00 MRP SOOmg x 6's pack: 1 80.00 MRP

Erythromycin 12Smg/Sml: suspension. 100ml bot: S6.00 MRP Erythromycin 12SmglSml: suspension. lOOml bot: SS.OO MRP

Azithromycin 2S0mglcapsule 2S0mg x lO's pack: 200.00 MRP

.:. AZIN Susp. Acme

.:. AZINIL Tab. Apex

.:. AZINIL Susp. Apex

Azithromycin 200mglSml: suspension. 20mI bot: 80.00 MRP .:. AZIROX Tab. Navana

Azithromycin SOOmgltablet 6's pack: 1 80.00 MRP .:. AZIROX Susp. Navana

Azithromycin 200mg/Sml: suspension. I Sml bot: 8S.00 MRP 30ml bot: 1 30.00 MRP .:. AZI-S SOO Tab. Seema

Azithromycin SOOmg/tablet

Once chily

®

znHROX SK+F

SOOmg x 6's pack: 1 80.00 MRP .:. AZI-S Susp. Seema

QIMP·15 (198) 6's pack: 303.42 MRP


.:. AZYTH Susp. SandozINovartis Azithromycin 200mglSmI: suspension.

.:. MACZITH Susp. Bio-pharma Azithromycin 200mg/Sml: suspension.

I Sml bot: 96.09 MRP

3Sml bot: 1 30.00 MRP

.:. BENZITH Cap. Benham Azithromycin USP SOOmglcapsule

.:. MAZITH 500 Tab. Hallmark Azithromycin SOOmg/tablet

Azithromycin 200mglSmI: suspension.


:. AZITEL-500 Cap. Cosmic

Azithromycin USP 200mg/SmI: suspension.

30ml bot: 1 80.00 MRP •

Azithromycin SOOmg/capsule

SOOmg x 4's pack: 1 00.00 MRP .:. AZITEL Susp. Cosmic Azithromycin 200mg/SmI: suspension.

I Sml bot: 8S.00 MRP

ISml bot: 8S.00 MRP

30ml bot: 1 30.00 MRP

.:. BENZITH Susp. Benham

ISml bot: 90.00 MRP

SOOmg x S's pack: 1 30.00 MRP

.:. MAZITH Susp. Hallmark Azithromycin 200mg/Sml: suspension .

I SmI bot: 8S.00 MRP

.:. BP-Z Cap. Bristol

2SmI bot: 1 1 0.00 MRP


.:. NEOZITH 500 Tab. Marksman Azithromycin SOOmgltablet

Azithromycin SOOmglcapsule

.:. BJ>-Z Susp. Bristol Azithromycin 200mglSml: suspension.

SOOmg x 3's pack: 7S.00 MRP

ISml bot: 8S.00 MRP

.:. NEOZITH Susp. Marksman Azithromycin 200mglSml: suspension.

.:. AZITIDN Susp. Chemist

.:. CINALID Tab. Jayson Azithromycin SOOmg/tablet

SOOmg x 3's pack: 7S.00 IP

.:. ODAZ-500 Tab. UniHealth

Azithromycin SOOmgltablet


.:. CINALID Susp. Jayson

SOOmg X 3's pack: 90.00 MRP

ISml bot: 7S.00 IP

.:. ODAZ Susp. UniHealth Azithromycin 200mglSml: suspension .

.:. AZITIDN Cap. Chemist

Azithromycin SOOmg/capsule


Azithromycin 200mg!Sml: suspension. .:. AZITHROCIN Cap. Beximco Azithromycin 2S0mglcapsule

lO's pack: 200.00 MRP

.:. AZITHROCIN Tab. Beximco

Azithromycin 200mg/SmI: suspension. • :. DEMACRO-500 Tab. Decent Azithromycin SOOmg/tablet


4's pack: 1 20.00 MRP

.:. AZITHROCIN Susp. Beximco

Azithromycin 200mg/SmI: suspension.


ISml bot: 8S.00 MRP

.:. ODAZYTH 250 Cap. ACI

Azithromycin 2S0mglcapsule .

.:. DEMACRO Susp. Decent



ISml bot: 8S.00 MRP

.:. ODAZYTH Tab. ACI Azithromycin SOOmgltablet

30ml bot: 1 30.00 MRP

.:. EZITH Tab. Edruc Azithromycin SOOmg/tablet



:. AZITHROMAX 500 Tab. Ziska

•

Azithromycin SOOmgltablet S's pack: I SO.OO MRP

.:. AZITHROMAX Susp. Ziska Azithromycin 20OmglSml: suspension.

ISml bot: 8S.00 MRP

6's pack: 1 80.00 MRP

3's pack: 90.00 IP

.:. ODAZYTH Susp. ACI Azithromycin 200mg/Sml: suspension .

.:. EZITH Susp. Edruc Azithromycin 200mglSml: suspension.

30ml bot: 1 30.00 IP

I Sml bot: 8S.00 IP .:. FIZYTH Tab. Peoples Azithromycin SOOmgltablet


.:. ODAZYTH IV Inj. ACI Azithromycin dihydrate USP SOOmg/Sml vial

(powder for reconstitution): i.v injection.


SOOmg (Sml vial) x I 's pack: 2S0.00 IP

.:. AZITOR 500 Tab. CPL Azithromycin SOOmg/tablet

.:. HYZITH-500 Tab. Milla! Azithromycin SOOmgltablet

3's pack: 90.00 MRP

.:. PENALOX Cap. Rephco Azithromycin SOOmg/capsule


.:. AZITRA 500 Tab. Syntho Azithromycin SOOmg/tablet

.:. HYZITH Susp. Milla!

Azithromycin 200mglSml: suspension.

.:. PENALOX Susp. Rephco Azithromycin 200mg/Sml: suspensi.on.

.:. AZIX Tab. Amico

.:. ILOZIN Tab. Doctor's

3Sml bot: 1 2S.00 MRP

S's pack: I S0.00 MRP

3's pack: 7S.00 MRP

ISml bot: 8S.00 MRP

ISml bot: 9S.00 MRP

.:. PHAGOCIN-500 Tab. SAPL


Azithromycin SOOmgltablet 6's pack: 1 80.00 MRP


3's pack: 90.00 MRP

.:. AZIX Susp. Amico

.:. ILOZIN Susp. Doctor's Azithromycin 200mglSml: suspension.

.:. PHAGOCIN Susp. SAPL


.:. MACAZI Tab. Pacific

.:. RANZITH Cap. Rangs Pharma

Azithromycin 200mglSmI: suspension. ISml bot: 80.00 MRP

ISml bot: 8S.00 MRP

.:. AZMIN Cap. Modern Azithromycin SOOmglcapsule


4's pack: 1 12.00 MRP

3's pack: 89.40 MRP


.:. MACAZI Susp. Pacific

:. AZO 500 Tab. Delta Azithromycin SOOmgltablet •

Azithromycin 200mglSml: suspension. ISml bot: 64.00 MRP

6's pack: 1 80.00 MRP

3Sml bot: 1 1 8.00 MRP

.:. AZO Susp. Delta Azithromycin 200mglSml: suspension.

.:. MACROZITH Cap. Silva Azithromycin 2S0mglcapsule


30ml bot: 1 30.00 MRP .:. AZOMAC 500 Tab. General Azithromycin SOOmgltablet

6's pack: 1 80.00 MRP

:. AZOMAC Susp. General Azithromycin 200mglSml: suspension. •

ISml bot: 8S.00 MRP

3Sml bot: 1 30.00 MRP .:. AZYTH Tab. SandozINovartis





.

Azithromycin 2S0mg/capsule


.:. RANZITH Susp. Rangs Pharma Azithromycin 200mg/Sml: suspension.


.:. RESPAZIT Cap. Somatec

Azithromycin 2S0mg/capsule


.:. MACROZITH Tab. Silva

.:. RESPAZIT Tab. Soma!ec Azithromycin SOOmg/tablet


SOOmg x .6's pack: 168.00 MRP


.:. MACROZITH Susp. Silva



.:. RESPAZIT Susp. Somatec Azithromycin 200mg/Sml: suspension.

2Sml bot: l 1S.00 MRP


.:. MACZITH Tab. Bio-pharma Azithromycin 2S0mg & SOOmgltablet

.:. ROMYCIN Cap. Ibn Sina Azithromycin 2S0mg/capsule

ISml bot: 8S.00 MRP


I SmI bot: 80.00 MRP

2S0mg x 8's pack: 160.00 IP

ANTIMICROBIAL DRUGS

QIMP.15 (199)

.:. ROMYCIN Tab. Ibn Sina


.:. ZITHRIN Susp. Renata


:. TYZITH Susp. Proteety

Azithromycin 200mg/5ml: suspension.


•


15m1 bot: 80.00 MRP

.:. ROMYCIN Susp. Ibn Sina

ISml bot: 7S.00 MRP

iOml bot: 85.00 MRP


.:. XOLIDE Cap. Radiant

3SmI bot: J30.00 MRP

ISml bot: 8S.00 IP

.:. ZITHRO Cap. Pharmadesh

3Sml bot: 1 30.00

IP

Azithromyein 2S0mg & SOOmglcapsule 2S0mg x 6's pack: ISO.OO MRP

Azithromycin 2S0mg & 500mglcapsule

.:. ROZITH Tab. HeaIthcare



Azithromycin 2S0mg & SOOmgltablet



.:. XOLIDE Susp. Radiant Azithromycin 200mglSml: suspension.


30ml bot: 1 30.00 MRP

Azithromycin 200mgl5ml: suspension.


.:. ZEMYCIN Tab. Gaco

.:. ROZITH Susp. Healthcare


.:. ZITHRO Susp. Pharmadesh ISmI bot: 85.80 MRP 30ml bot: 125.00 MRP


3's pack: 89.99 MRP

.:. ZITHROLEX Tab. Mystic

I SmI bot: 8S.00 MRP

Azithromycin 2S0mg & SOOmgltablet

22.Sml bot: 90.00 MRP .

.:. ZEMYCIN Susp. Gaco Azithromycin 200mglSmI: suspension.

3Sml bot: 1 30.00 MRP

lSml bot: 8S.00 MRP



.:. SIMPLI·3 Tab. Beacon

.:. ZEOCIN-500 Tab. A.P.C Pharma

.:. ZITHROLEX Susp. Mystic


Azithromycin 500mgltablet

Azithromycin 200mg/Sml: suspension.


3's pack: 90.00 IP


.:. SIMPLI-3 Susp. Beacon

.:. ZmAC Tab. Popular Azithromycin 2S0mg & SOOmgltablet . 2S0mg x 8's pack: 160.00 MRP

.:. ZITHROX Tab. SK+F Azithromycin 2S0mg & 500mgltablet


500mg x 6's pack: 1 82.00 MRP

Azithromycin 12SmglSmI: suspension. 3SmI bot: 1 30.00

MRP

.:. SIMPLI·3 Inj. Beacon

250mg x 6's pack: 1 20.00 MRP

Azithromycin dihydrate USP SOOmglSmI vial

.:. ZmAC Susp. Popular

.:. ZITHROX Susp. SK+F



Azithromycin 200mg/5ml: suspension.

SOOmg (SmI vial) x I 's pack: 2S0.00 MRP

ISmI bot: 8S.00 MRP

.:. SOTO Tab. Hudson

3Sml bot: 1 30.00

MRP

1 5m1 bot: 96.00 MRP 30ml bot: 1 30.00 MRP

Azithromycin USP SOOmgltablet

.:. zmAC I.V Inj. Popular

.:. ZITREX 500 Tab. Medicon

SOOmg x 8's pack: 240.00

Azithromycin dihydrate USP SOOmglSmI vial


.:. SOTO Susp. Hudson



Azithromycin USP 200mglSml: suspension.

SOOmg (Sml vial) x l 's pack: 2S0.00 MRP

MRP


.:. TmZA Tab. Kumudinl Azithromycin SOOmgltablet SOOmg x 8's pack: 240.00 MRP

.:. TmZA Susp. Kumudinl Azithromycin 200mglSmI: suspension. ISml bot: 8S.00 MRP

.:. THROMAX Tab. Novo Healthcare Azithromycin 2S0mg & SOOmgltablet 2S0mg x 6's pack: 1 20.00 MRP SOOmg x 3's pack: 90.00 MRP

.:. THROMAX Susp. Novo Heallhcare

Azithromycin 200mglSmI: suspension. ISml bot: 90.00 MRP 3Sml bot: 1 30.00 MRP

.:. TRIDOSIL Tab. Incepta Azithromycin 2S0mg & SOOmgltablet 2S0mg x 6's pack: 1 20.00 MRP SOOmg x 6's pack: 1 80.00 MRP

:. TRIDOSIL Susp. Incepta

•

Azithromycin 200mglSmI: suspension. 20ml bot: 8S.00 MRP 3SmI bot: 1 30.00 MRP

.:. TRIDOSIL I.V Inj. Incepta Azithromycin dihydrate USP SOOmglSmI vial

:. ZIMAX Cap. Square

•

Azithromycin 2S0mg/capsule 6's pack: 1 20.00 MRP

.:. ZIMAX Tab. Square Azithromycin SOOmgltablet 6's pack: 1 80.00 MRP

.:. ZIMAX Susp. Square Azithromycin 200mglSml: suspension. I Sml bot: 8S.00 MRP

.:. ZITRE){ Susp. Medicon Azithromycin 125mg/SmI: suspension . ISml bot: 80.00 MRP

.:. ZYCIN-500 Tab. Globe Azithromycin 500mgltablet 1 2's pack: 360.00 MRP

.:. ZYCIN Susp. Globe Azithromycin 200mglSmI: suspension. I Sml bot: 80.00 MRP 30ml bot: 1 20.00 MRP

.:. ZINEX Cap. Alco Pharma Azithromycin 2S0mg & 500mglcapsule 250mg x 6's pack: 90.00 MRP 500mg x 8's pack: 200.00 MRP

.:. ZINEX Susp. Alco Pharma Azithromycin 200mg/Sml: suspension. 15ml bot: 75. 00 MRP 30ml bot: 1 30.00 MRP

.:. ZITA-SOO Tab. Chemico Azithromycin SOOmgltablet 3's pack: 90.00 MRP 6's pack: 1 80.00 MRP

CLARITHROMYCIN21,49 CLARITHROMYCIN: Tablet! SuspensionlInfusion Ind: Respiratory tract infections (acute & chronic bronchitis, pneumonia); sinusitis, pharyngitis; otits media; skin & soft tissue infections. Eeradication of H. pylori for the treatment of duodenal ulcers .

CII: Hypersensitivity to clarithromycin or any other macrolide antibiotics.

.:. ZITA Susp. Chemico Azithromycin 200mgl5m1: suspension.

SIE: Cautions: See under Erythromycin; reduce


impairment, pregnancy and breast feeding; also

dose in renal impairment; caution in heapatic

30ml bot: 1 30.00 MRP

reported, headache, taste disturbances, stomatitis,

.:. ZITHRIN Tab. Renata Azithromycin 250mg & 500mgltablet

glOSSitis, cholestasis, jaundice, hepatitis and

250mg x 6's pack: 108.00 MRP

tenderness, phlebitis.

250mg x 8's pack: 160.00 MRP

500mg x 12's pack: 360.00 MRP

Arrhythmias- avoid concomitant administration

500mg x 4's pack: 1 20.00 MRP

:. ZITHRIN·Cap. Renata Azithromycin 2S0mglcapsule

Dosage & admin: By mouth, 2S0mg every 12

6's pack: 1 20.00 MRP

hours for 7 days, increased in severe

(powder for reconstitution): i.v injection. SOOmg (SmI vial) x l's pack: 2S0.00 MRP

.:. TRUZITH Tab. White Horse Azithromycin USP 250mg & SOOingltablet

.:. TRUZITH Susp. White Horse Azithromycin 200mglSmI: suspension.

•

Stevens-Johnson syndrome; on i. v infusion, local

with astemizole, terfenadine or cisapride .

QIMP·15 (200)

ANTIMICROBIAL DRUGS infections to 500lllg every 12 hours for up to 14 days. Child- body weight under 8kg, 7.5mgikg twice daily; 8·11 kg (1-2 years), 62.5mg twice daily; 12-19 kg (3-6 years), 125mg twice daily; 20-29 kg (7·9 years), 187.5mg twice daily; 30.40kg (10·12 years), 250mg twice daily. Eradication of H. pylori- 500mg twice daily for 7 days in combination with other preparations of the recomme-nded regimens. By i.v infusion into larger proximal vein, 500mg twice daily; Child not recommended. .:. BINOCLAR Tab. Sandoz/Novartis

Clarithromycin 500mgltablet 500mg x l4's pack: 920.36 MRP

.:. BINOCLAR SR Tab. SandozINovartis

Clarithromycin 500mgltablet (sustained release) 500mg x lO's pack: 780.00 MRP .:. BINOCLAR Susp. SandozINovartis

Clarithromycin 125mg/5ml: suspension 60ml bot: 340.00 MRP .:. CLACIN Tab. Medimet

Clarithromycin 500mgltablet 500mg x 4's pack: 1 60.00 MRP .:. CLARICIN Tab. Acme

Clarithromycin 250mg & 500mg/tablet 250mg x 8's pack: 200.00 MRP 500mg x 8's pack: 320.00 MRP .:. CLARIN Tab. Drug Inter

Clarithromycin 250mg & 500mgltablet 250mg x 10's pack: 320.00 MRP 500mg x lO's pack: 350.00 MRP .:. CLARISON Tab. Hudson

Clarithromycin 500mgitablet 500mg x lO's pack: 450.00 MRP :. KLARICID XL Tab. AbbottlUniHealth

•

Clarithromycin 500mgl.tablet (extended release) 500mg x 5's pack: 498.93 MRP .:. KLARICID Susp. AbbottlUniHealth

Clarithromycin l 25mg/5ml: suspension 60ml bot: 5 16.28 MRP

.:. KLARICID I.V Inj. AbbottlUniHealth

Clarithromycin lactobionate 500mglvial: i.v injectio!l I vial pack: 464. 1 5 MRP .:. MACLAR Tab. Techno Drugs

Clarithromycin 250mg & 500mgltablet 250mg x 6's pack: 1 80.00 MRP 500mg x 6's pack: 240.00 MRP .:. MACLAR Susp. Techno Drugs

Clarithromycin 1 25mgl5ml: suspension 60ml bot: 300.00 MRP :. MACLAR LV Inj. Techno Drugs

•

Clarithromycin lactobionate 500mg/vial: i. v injection I vial pack: 300.00 MRP .:. MACROBID Tab. General

Clarithromycin 500mg/tablet 500mg x 4's pack: 200.00 MRP .:. REMAC Tab. Square

Clarithromycin 500mgltablet 500mg x 6's pack: 240.00 MRP :. ROLACIN Tab. Beximco

•

Clarithromycin 250mg & 500mgltablet 250mg x 20's pack: 500.00 IP 500mg x lO's pack: 400.00 IP

ROXITHROMYCIN21,26

ROXITHROMYCIN: Tablet/Suspension

Roxithromycin is a macrolide with antibacterial properties sintilar to erythromycin. It is a broad spectrum antibiotic and effective against a good range of gram positive & gram negative bacteria including atypical pathogens like mycoplasma and chlamydia. It is well-tolerated by adults and children. Roxithromycin is well absorbed on oral administration. It has a mean plasma half·life of 9· 1 6 hours and once or twice daily dosing is sufficient to maintain adequate bactericidal activity in plasma and tissues. It is metabolized in the liver; excretion occurs mainly through faeces and also through respiratory tract & urine. Ind: Roxithromycin is indicated in the treatment of infections caused by susceptible microorganisms: Respiratory infections like pneumonia, acute and . chronic bronchitis, bronchopneumonia; ENT infections like tonsillitis, pharyngitis, sinusitis and otitis media; Skin infections like folliculitis, furuncles, cellulitis, carbuncles, pyoderma, impetigo and infected dermatitis; Genital infections like urethritis, prostatitis, cervicitis and salpingitis specially if produced by chlamydia . trachomatis. CII: History of hypersensitivity to the drug. SIE: Roxithromycin is well-tolerated by patients of all age groups. Less than 4% of treated patients complain of side·effects mainly nausea, abdominal pain, diarrhoea and hypersensitivity rash. Other side-effects reported include vomiting, dizziness, headache, pruritus, dyspepsia, flatulence, tinnitus, vertigo and constipation. These are in general minor and do not necessitate withdrawal of therapy. Precautions: In patients with hepatic diseases the dose of roxithromycin should not exceed 1 50mg twice a day. The safety of roxithromycin in pregnancy has not been established. It appears in breast milk in small amounts and does not prodlice adverse effects in the breast fed infant. Accumulation does not occur in patients with compromised renal function and dosage adjustment is not necessary. Roxithromycin should not be administered simultaneously with ergotamine or its derivatives as it may provoke arterial spasm and severe ischaemia. Dosage & admin: Adult dose- 300mg once daily or 150mg twice daily for at least two days after resolution of symptoms; a normal course of therapy is between 5 and 10 days. In severe hepatic impairment the dose is 150mg once daily. Roxithromycin is best administered on empty stomach. Children: 2.5-5mgikg body weight twice a day. The following general guidelines can be followed- 6-11kg, 25mg 12 hourly; 12·23kg, SOmg 12 hourly; 24-40kg, 100mg 12 hourly. A normal course of therapy is .between 5 and 10 days. Drug Inter: Roxithromycin shows mild

interaction with theophylline though this has not been found to produce clinically relevant effects . Antacids, H2·receptor antagonists and food has no effect on the absQl1ltion of roxithromycin. .:. A-ROX Tab. Ambee

Roxithromycin BP 1 50mg & 300mgltablet 150mg x 30's pack: 1 95.00 MRP

300mg x 20's pack: 220.00 MRP .:. A·ROX Susp. Ambee

Roxithromycin BP 50mgl5ml: suspension 50ml bot: 45.00 MRP .:. PEDILID Tab. Incepta

Roxithromycin BP 150mg & 300mgltablet 1 50mg x 50's pack: 350.00 MRP 300mg x 30's pack: 420.00 MRP .:. PEDILID Susp. Incepta

Roxithromycin BP 50mg/5ml: suspension 50ml bot: 50.00 MRP .:. ROCKY Susp. Amico

Roxithromycin BP 50mg/5ml: suspension 50ml bot: 40.00 MRP .:. ROLID Tab. Globe

Roxithromycin BP 150mg & 300mgltablet 150mg x 50's pack: 350.00 MRP 300mg x 30's pack: 420.00 MRP .:. ROLID Susp. Globe

Roxithromycin BP 50mgl5ml: suspension 50ml bot: 45.00 MRP .:. ROXCIN Tab. Alco Pharma

Roxithromycin BP 150mg & 300mg/tablet 1 50mg x 20's pack: 1 20.00 MRP 300mg x 20's pack: 240.00 MRP .:. ROXCIN Susp. Alco Pharma

Roxithromycin BP 50mgl5ml: suspension 50ml bot: 45.00 MRP .:. RYTH Tab. Navana

Roxithromycin BP 1 50mg & 300mgltablet 150mg x 18's pack: 1 26.00 1P 300mg x 18's pack: 252.00 IP .:. RYTH Susp. Navana

Roxithromycin BP 50mg/5ml: suspension 50ml bot: 50.00 IP

SPlRAMYCIN21 ,35 .:. ROVAMYCINE Tab. Sanofi-averitis

Spiramycin 1 .5 MIU & 3 MIU/tablet Ind: Species usually sensitive· streptococcus, pneumococcus (as in resp. tract infections), meningococcus, gonococcus, bordetella pertussis, c.diphtheriae, listeria monocytogenes, clostridium, mycoplasma pneumoniae, chlamydia trachomatis, legionella pneumophilia, treponema, lep.tospira, campylobacter, toxoplasma gondii. Species inconsistently sensitiveh. influenzae, vibrio cholerae, staph. aureus. Infections due to organisms mentioned above to be sensitive, particularly in the following clinical situations: E.N.T, bronchopulmonary, dermatolo·gical, genital (following prostatic) and bone infections . Prophylaxis of meningo-coccal meningitis in contact subjects. Chemoprophylaxis of recurrence of rheumatic fever. Toxoplasmosis in pregnant women and in irnmunodepressed subjects. CII: Known hypersensitivity to macrolides. SIE: Gastro·intestinal effects· nausea, vomiting, diarrhoea, sometimes leading to withdrawal of treatment. Allergic skin reactions. Precautions & warnings: The dosage does not need to be modified in patients with renal inpairment, because of the absence of renal excretion of the actiye molecule. As spiramycin passes into the maternal milk, usiog a milk substitute, or should not be given during breast-feeding if there is alternative

QIMP-15 {201l antimicrobial is available.

ANTIMICROBIAL DRUGS

Dosage & admin: By mouth: The usual adult

In pregnancy spiramycin can safely be

dosage for patients with serious infections is

prescribed.

150-300mg every 6 hours. For more severe

Dosage & Admin: Adults- 6 to 9 MIU/day to

infections 300·450mg every 6 hours is advised.

be divided in 2 or 3 doses. · Children- weight more than 20kg, 1.5 MIU per

For acute pharyngitis/tonsillitis, the

lOkg of hody weight per day, to be divided in 2

for 10 days. To avoid the possibility of

or 3 doses.

esophageal irritation, capsules should be taken

Prophylaxis of meningococcal meningitis

with a full glass of water.

recommended dosage is 300mg every 12 hours

adults, 3 MIU/12 hours for 5 days; children,

By injection: The usual adult daily dosage for

75,000 1U/12 hours for 5 days.

infections of the intra-abdominal area, female

3 MIU x 20's pack: 400.00 MRP

infections due to more susceptible

potentially toxic, which should be reserved for

For children over 1 month of age, the dosage

produced by chlorosubstitution of the

hydroxylgroup of the parent compound lincomycin.

Mode of action: Clindamycin may be either

bactericidal or bacteriostatic depending on the sensitivity of the micro-organism

& the

wncentration of the antibiotic at the site of

action.

Ind: Clindamycin has been found active against

Gram-positive cocci including penicillin-resistant Staphylo cocci, Streptococci (except S. faecalis), Pneumoccoci; also many anaerobes specially Bacteroides fragilis.

Clindamycin is indicated in the following infections caused by the susceptible strains of above bacteria.

I . Upper respiratory infections

& lower

respiratory infections including bronchitis, pneumonia, empyema. and lung abscess.

2. Skin and soft tissue infections including acne. 3. Bone ado joint infections including osteomyelitis and septic arthritis.

4. Gynaecological infections including pelvic inflammatory diseases when given in conjunction with an antibiotic of appropriate garm-negative

spectrum.

5. Intra-abdominal infections including peritonitis

and abdominal abscess given with an appropriate gram-negative aerobic antibiotic.

is 20-40mglkglday divided in 3 or 4 equal dose. In neonates (under 1 month of age), the dose is 15-20mglkglday divided in 2, 3 or 4 equal doses. Single intramuscular doses of greater than 600mg are not recommended. The concentration of c1indamycin in diluent for infusion should not exceed 18mg per ml and infusion rates should not exceed 30mg per

7. Dental infections such as periodontal abscess and periodontitis, etc.

CIl: Previously found to be sensitive to clindamycin or lincomycin. Diarrhoeal diseases.

SIE: Abdominal pain, nausea, vomiting,

neutropenia and eosinophilia, agranulocytosis and thrombocytopenia have been reported.

Cautions: Discontinue immediately if diarrhoea

or colitis develops; impaired hepatic or renal functions.

aplastic anaemia, peripheral neuritis, optic

neuritis, erythema multiforme; nausea, vomiting, diarrhoea.

Cautions: Avoid repeated courses

treatment; reduce doses in hepatic

& prolonged & renal

impairment; periodic blood counts required;

interferes with development of immunity; caution

6 hours, or 50 mglkglday in divided doses. By i.v. or i.m. injection 1

certain indications, parenteral therapy may be

Child, pyogenic meningitis, 50·100mglkg daily

changed to oral when the condition warrants

in divided doses every 6 hours.

gm every 6-8 hours.

and at the discretion of the physician.

Neoborn & premature infants, 25mglkg body

Drug inter: Antagonism has been demonstrated

wt.

between clindamycin and erythromycin.

.:. CLINDACIN Cap. Incepta Clindamycin hydrochloride 150mg 300mglcapsule.

&


.:. CLINDACIN 300 Inj. Incepta

Clindamycin phosphate BP equivalent to clindamycin 300mgl2ml ampOUle: i.m1i. v injection.

300mg (2ml) amp x 5's pack: 200.00 MRP

.:. CLINDACIN 600 Inj. Incepta

Clindamycin phosphate BP equivalent to injection.

600mg (4mI) amp x 5's pack: 350.00 MRP Clindamycin hydrochloride 1 50mg

100's pack: 220.00 MRP

.:. CHLOROOL Cap. Seema

Chloramphenicol 250mglcapsule.

1 50mg x 30's pack: 240.00 MRP

300mg x 30's pack: 450.00 MRP

.:. CLINDAX Cap. Opsonin

.:. CHLORAMPHENICOL Cap. Hudson

Chloramphenicol 250mglcapsule.

&

300mg/capsule. 150mg x 30's pack: 240.00 MRP

Clindamycin phosphate BP equivalent to

clindamycin 300mgl2ml ampOUle: i.m1i.v injection.

300� (2mI) a!DP x 5's pack: 200.00 MRP

.:. CLINDAX 600 Inj. Opsonin Clindamycin phosphate BP equivalent to clindamycin 600mgl4mI ampOUle: i.m1i. v injection. 600mg (4mI) amp x 5's pack: 350.00 MRP

also appears in the breast milk from 0.7 to

Clindamycin hydrochloride 300mglcapsule.

3 .8mcglmI.

SIE: Leucopenia, thrombocytopenia, irreversible

this antibiotic should be discontinued. For

Pregnancy & lactation: Safety of clindamycin

for use in pregnancy has not been established. It

& also for

significant diarrhea occurs during therapy,

.:. CLINDAX 300 Inj. Opsonin

morbilliform-like skin rashes; transient

influenzae or klebsiella penumoniae

typhoid fever (salmonella group).

in neonates (may cause grey daby syndrome).

300mg x 30's pack: 450.00 MRP

rash and urticaria, generalized mild to moderate

the treatment of life threatening infections, particularly those caused by haemophylus

Dosage & admin: By mouth, 250-500mg every

& abnormalities in liver function

hypersensitivity reactions such as, maculopapular

&

minute. Administration of more than 1200mg

diarrhoea, pseudo-membranous colitis; jaundice tests;

Ind: Broad spectrum antibiotic, is a potent

in a single infusion is not recommended. If

clindamycin 600mgl4ml ampoule: i.m1i. v

6. Septicemia and endocarditis.

CHLORAMPHENICOLZI .33

Injection.

equal doses.

Clindamycin is a semi-synthetic antibiotic

& Teicoplanin.

CHLORAMPHENICOL: Capsule! Syrup/

such as 1200mglday given divided in 3 or 4

CLINDAMYCIN HCI: TabletlInjection

group (Linezolid), Polymyxins, Spectinomycin,

Vancomycin

pelvis and other complicated or serious

microorganisms may respond to lower doses

CLINDAMYCIN

Drugs discussed under miscellaneous groups are Chloramphenicol, Fusidic acid, Oxazolidinone

infections is 2400-2700mglday · given divided

in 2, 3 or 4 equal doses. Less complicated

1.6 Clindamycin

1.7 Misc. Antibiotics

.:. CHLOROOL Susp. Seema Chloramphenicol 1 25mgl5mI: suspension 60mI bot: 20.00 MRP

.:. CHLORPHEN Cap. Nipa

Chloramphenicol 250mglcapsule 100's pack: 200.00 MRP

.:. EDRUMYCETIN Cap. Edruc

Chloramphenicol 250mglcapsule. 100's pack: 250.00 MRP

.:. OPSOMYCETIN Susp. Opsonin

Chloramphenicol 1 25mg/5mI: suspension 60ml bot: 1 6.00 MRP

.:. RAMICOL Cap. Skylab

'

Chloramphenicol 250mglcapsule. 100's pack: 295.00 MRP

.:. RAMICOL Susp. Skylab Chloramphenicol 125mgl5mI: suspension 60mI bot: 23.00 MRP

FUSIDIC AC1D2 1 .73 .:. FUCIDIN Tab. Leo Pharmal Kapricorn

Sodium fusidate 250mgltablet

Ind: Infections caused by penicillin resistant

staphylococci (specially osteomyelitis. as they are

.:. DALACIN C Cap. Pharmacia-Pfizer/Janata

well concentrated in bone; a second anti

300mg x 16's pack: 768.16 MRP

SIE: Nausea, vomiting, rashes, jaundice,

staphylococcal antibiotic is usually required.)

ANTIMICROBIAL DRUGS

QIMP-15 (202)

reversible change in liver function.

Pregnancy & lactation: Linezolid is not

Spectinomycin is an antibiotic belonging to the

Cautions: Hepatic insufficiency.

teratogenic and still like all other drugs it should be used during pregnancy only if the potential

miscellaneous antimicrobials. It is available as

Dosage & admin: 2S0-S00mg evevy 8 hourly. 20's pack: 1878.40 MRP

benefit justifies the potential risk to the foetus. Although it is known not to be excreted in breast

Oxazo lidinoneS2.62.120 Oxazolidinone is a new class of antibiotics belonging to the miscellaneous antimicrobials. The drugs of this group are organically synthesised and absorbed excellently by oral administration. The mechanism of action of this class of antibiotics differs from that of existing antimicrobial agents. Therefore, cross resistance to other antimicrobials is less likely and has been shown to date. There is only one preparation of this group, currently available for clinical use

Linezolid.

milk, caution should be exercised when linezolid

LINEZOLID: Tablet Linezolid is the first and only product of oxazolidinone group currently available for clinical use. It is active against a wide range of gram-positive bacteria including methicillin resistant staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE) and penicillin-resistant pneumococci, but not against any gram negative pathogens.

Mode of action: Linezolid is a bacteriostatic antibiotic. It selectively inhibits bacterial protein synthesis by binding to a site on the bacterial ribosome and preventing the formation of the functional complex which is an essential component of the translation process.

Ind: Linezolid is indicated for the treatment of severe infections of different organs and systems of the body caused by most gram-positive bacteria, viz. vancomycin-resistant enterococcus faecium infections, nosocomial or community acquired pneumonia and uncomplicated or complicated skin and skin structure infections.

CII: Known case of hypersensitivity to linezolid or any of the other product components.

SIE: Linezolid is well tolerated. The most common adverse events in patients treated with linezolid are- diarrhoea, headache and nausea. Other adverse events reported are- insomnia, constipation, dizziness, oral moniliasis, vaginal moniliasis, hypertension, dyspepsia, localised abdominal pain, rash, pruritus, tongue discolouration, pseudomembranous colitis and myelosuppression.

Precautions: If superinfection occurs during therapy, appropriate measures should be taken. Linezolid has not been studied in patients with uncontrolled hypertension, pheochromocytoma, carcinoid syndrome or untreated hyperthyroidism. The safety and efficacy of linezolid formulations given for longer than 28 days have not been evaluated in controlled clinical trials. Platelet counts should be monitored in patients who are at increased risk of bleeding, who have pre-existing thrombocytopenia, who receive concomitant medications that may decrease platelet count or

CII: Pregnancy

& brest-feeding; children below

two years.

Dosage & admin: Adult: The usual adult dose

SIE: Nausea, dizziness, urticaria, fever.

of Iinezolid is 400-600mg 12 hourly regardless

Dose: Male- single 2gm dose (Sml); Female

of meals for 7-28 days depending on the type

single 4gm dose (10ml) Lm deep in the

and severity of the infection and the patients

buttock.

clinical response. The recommended dosage

Children: Not recommended; but, if no

for specific indications are as below:

alternative, 40mg/kg over 2 years of age.

Vancomycin.resistant enterococcus faecium infection including concurrent bacteremia: 600mg 12 hourly for 14 to 28 days. Nosocomial pneumonia, community-acquired pneumonia

.:. TlNOBAC Inj. Incepta

Spectinomycin 2gm vial: injection. 2gm vial: 250.00 MRP

including concurrent bacteremia and complicated skin and skin structure infection: Uncomplicated skin and skin structure infection: 400mg 12 hourly for 10 to 14 days. .Elderly patients: No dose adjustment is required for elderly patie,nts. Children: Studies using doses higher than lOmg/kgldose every 12 hours have not been conducted in paediatric patients. Not studied In infants below 3 months of age.

Overdose: In the event of overdosage, supportive care is advised with maintenance of glomerular filtration. Haemodialysis may facilitate more rapid elimination of linezolid.

Drug inter: Linezolid is a reversible, nonselective inhibitor of monoamine oxidase. Therefore, linezolid has the potenti�l for interaction with adrenergic and serotonergic agents. Patients receiving linezolid need to avoid consuming large amounts of foods or beverages with high tyramine content. A reversible enhancement of the pressor response of either pseudoephedrine hydrochloride or phenylpropanolamine hydrochloride is observed when linezolid is administered to healthy nonnotensive.

.:. ARLIN-600 Tab. Beximco

Linezolid

INN 600mgltablet (film coated).

600mg x 20's pack: 1700.00 IP

.:. ARLIN Susp. Beximco

Linezolid INN l OOmgl5ml: suspension. l OOml bot: 280.00 IP

.:. LlNEZ Tab. Renata

Linezolid INN 400mg

VANCOMYCIN I 21 VANCOMYCIN: Injection. Vancomycin is an amphoteric glycopeptide antimicrobial substance produced by the growth of certain strains of Nocardia

orientalis. It is

bactericidal aganist many gram positive organisms including staphylococci, streptococci, corynebacterium and clostridium, including clostridium difficile. Gram negative bacteria, mycobacteria and fungi are resistant. Vancomycin is available as vancomycin hydro chloride 500mg vial injection for i.v infusion.

Mode of action: Vancomycin is bactericidal against many gram positive organisms. It appears to act by inhibiting the production of bacterial cell wall mucopeptide. Gram-negative bacteria, mycobacteria and fungi are found resistant to vancomycin.

Ind: Potentially life-threatening infections which cannot be treated with another effective, less toxic antimicrobial drug, including the penicillins and cephalosporins. Vancomycin injection is useful in therapy of severe staphylococcal (including methicillin resistant staphylococcal) infections.

& 600mgltablet (f.c).


Vancomycin injection is effective alone or in combination with an aminoglycoside for endocarditis caused by Strep. viridans or Strep. bovis. For endocarditis caused by enterococci (e.g Strep. faecalis), Vancomycin is effective only in combination with an aminoglycoside. Vancomycin is effective for the treatment of diptheroid endocarditis. Vancomycin injection is used in combination with rifampicin, an


aminoglycoside, or both in early onset prosthetic

.:. LINEZ Susp. Renata Linezoiid INN 1 00mg/5ml: suspension.

or diphtheroids.

60ml bot: 175.00 MRP l OOml bot: 280.00 MRP 150ml bot: 420.00 MRP

.:. LIZEN Tab. Zenith

Linezolid INN 600mgltablet (film coated). 600mg x 30's pack: 2550.00 MRP

.:. LlZEN Susp. Zenith

Linezolid INN l OOmgl5ml: suspension.

valve endocarditis caused by staph. epiderrnidis Vancomycin injection should be administered orally for the treatment of staphylococcal enterocolitis and antibiotic associated pseudomembranous colitis (produced by Cl. difficile). For oral administration the parenteral formulation may be used.

CII: Known hypersensitivity to this drug. Adverse reactions:

lOOmi bot: 280.00 MRP

Infusion relnted events: During or soon after

SPECTINOMYCIN21 .60

hypotension, palpitations, substernal pressure,

SPECTINOMYCIN: Injection

pruritus. Rapid infusion may cause flushing of

infusion of vancomycin injection, patients may develop anaphylactoid reactions including tachycardia, Wheezing, dyspnoea, urticaria, or

function or who may require longer than 2 weeks of linezolid therapy.

proctitis.

is administered to a nursing woman.

600mg 12 hourly for 10 to 14 days.

LINEZOLID62.120

2gm vial for intramuscular injection.

Ind: Acute gonorrhoeal urethritis, cervicitis and

QIMP·lS (203) the upper body ("red neck") or pain and muscle spasm of the chest and back. These reactions usually resolve within 20 minutes, but may persist for sveral hours.

Auditory & Vestibular: Sensorineural deafness

Vancomycin injection: Dosage in patients with impaired renalfunction: Creatinine 100 90

which may be accompanied by tinnitus may

70 60

Cardiovascular: Hypotension, palpitations,

50 40

substernal pressure, tachycardia (see infusion

30

related events).

20 10

Gastrointestinal: Oral doses are extremely

unpalatable. In leukaemic patients, oral dosing

Haematological: Eosinophilia, thrombocytopenia and neutropenia.

Immunological: Hypersensitivity reacitons with chills, nausea, urticaria, macular rash, fever and

rigors. Anaphylactoid reactions have been reported infrequently.

Renal: Cases of interstitial nephritis and renal

failure have been reported.

Precautions: Vancomycin i.v should be

administered in a dilute solution at a rate not

exceeding SOOmg/hour to avoid rapid·inusion· related reactions. Because of its ototoxicity and nephroto·xicity, vancomycin should be used with care in patients with renal insufficiency. The use of vancomycin may result in overgrowth of nonsusceptible organisms. In rare instances there have been reports of pseudomembranous colitis due to C. difficile. Since vancomycin is irritating to tissue and causes drug fever, pain and possibly necrosis it should never be injected LM; it must be administered LV. Pain and thrombophlebitis occur in many patients receiving vancomycin and are occasionally severe. The frequency and severity of thrombophlebitis can be minimised if the drug is administered in a volume of at least 200ml of glucose or saline solution anti if the injection sites are rotated. Patients taking oral vancomycin should be warned of its offensive taste.

Pregnancy & lactation: As there is little

information on the use of vancomycin in

pregnancy, the drug should not be used in pregnant women or those likely to become pregnant unless the expected benefits outweigh any potential risk. Vancomycin is excreted in breast milk, but not known whether harmful to the newborn. Therefore, it is not recommended for nursing mothers unless the expected benefits outweigh any potential risk.

Dosage & admin: Adults: The usual i.v dose is 500mg for every 6 hours or Igm every 12 hours. A sOOmg dose of vancomycin should be infused over a period of at least 50 minutes, whereas a Igm dose should be administered

mgl24 hours

80

dizziness have also been reported.

regimens are associated with frequent nausea,

Vancomycin dose

clearance rnl/min.

occur but the incidence is low. Vertigo and

diarrhoea and occasional vomiting.

ANTIMICROBIAL DRUGS

1 545 1 390

infusion 0.9% or Glucose i.v infusion S%

770 620 465

310 155

Loaing dose: The initial dose should be not less than lsmgikg, even in patients with mild to moderate renal insufficiency.

Anephric patients: The table is not valid for functionally anephric patients. The majority of patients with infections caused by organisms susceptible to the antibiotic show a therapeutic response by 4872 hours. The total duration of therapy is determined by the type and severity of the infection and the clinical response of the patient. In staphylococcal endocarditis, therapy for 3 weeks or longer is recommended.

Children: The paediatric dosage of vancomycin is calculated on the basis of 10mgikg body weight every 6 hours after an initial loading dose of lsmgikg. Each dose should be administered over a period of at least 60 minutes.

Infants & Neonates: In neonates and young infants, the total daily i.v dosage may be

lower. An initial dose of Ismgikg is suggested,

followed by lOmgikg every 12 hours in the

first week of life and every eight hours there after until one month of age. Close monitoring of serum vancomycin concentrations is mandatory in these patients.

1 0mg!mI or Img!ml with Sodium chloride i.v vancomycin was chemically stable for 24 hours at 2S'C and 28 days at 2-8'C. However to avoid microbial contamination all

solutions should be used as soon as practicable

after reconstituted and within 24 hours of preparation.

Drug inter: Careful monitoring is required for the following: Streptomycin, neomycin,

gentamicin, kanamycin, amikacin, polymyxin b, colistin, ethacrynic acid, frusemide cholestyramine.

&

.:. VANCARD Inj. Techno Drugs

Vancomycin hydrochloride USP Soomg/vial

&

I gm/vial: injection for i.v infusion. 500mg vial x I 's pack: 24S.00 MRP Igm vial x I 's pack: 460.00 MRP

.:. VANCOMIN Inj. Opsonin

Vancomycin hydrOChloride USP SOOmg!vial

&

I gm/vial: injection for i.v infusion. SOOmg vial x I 's pack: 2S0.00 MRP Igm vial x I 's pack: 480.00 MRP .:. VANCOMYCIN HCI Inj. DBL/Globex

Vancomycin hydrochloride Soomg/vial: injection for i. v infusion.

SOOmg vial x I 's pack: 52S.00 MRP

:. VANMYCIN Inj. Incepta

.

Vancomycin hydrochloride USP SOOmg!vial I gm/vial: injection for i. v infusion.

&

SOOmg vial x I 's pack: 2S0.00 MRP Igm vial x I 's pack: 480.00 MRP

6 TEICOPLANIN2

Oral administration: The usual adult total daily dosage for antibiotic associated pseudomembranous colitis produced by C. difficile is sOOmg to 2gm given in 3 or 4 divided doses for 7 to 10 days. The total daily dosage in children is 40mgikg body-weight in 3 or 4 divided doses. The total daily dosage should not exceed 2gm. The contents of 1 vial (sOOmg or 500,000 i.u) may be diluted in 30ml of distilled or deionised water and given to the patient to drink, or the diluted material may be administered via

TEICOPLANIN: Injection

Teicoplanin is a glycopeptide bactericidal antibiotic, which is active against both anaerobic and aerobic gram-positive organisms. It is available as teicoplanin INN 200mg lyophilized

powder in vial for i.m or i.v injection.

Mode of action: Teicoplanin inhibits the growth

of susceptible organisms by interfering with cell·

wall bisynthesis at a site different from that

affected by beta-Iactams. It is active against staphylococci (including those resistant to

nasogastric tube. Common flavouring syrups

methicillin and other beta·lactam antibiotics),

may be added to the solution to improve the . taste for a oral administration.

micrococci, group J/K corynebacteria and gram·

time of use, the SOOmg (or 500,000 i.u) vials

and peptococci.

Preparation of solution for injection: At the

should be reconstituted with I Oml of water for

injection. The resulting solution contains vancomycin 50mg!mL The Igm (1 ,000,000 i.u) vial should be reconsituted with 20ml of water

must be further diluted with Sodium chloride i.v

elderly, the dosage calculations may be made

when stored at rC·8'C for 96 hours.

925

1080

Adults with impaired renal function and the elderly: Dose adjustment must be made in

by using the following table.

vancomycin SOmg!ml (SO,OOO i.u/mI) in water for injection do not show significant loss of potency When diluted to a concentration of either

for injection. The resulting solution contains

most patients with renal impairment or the

Stability of reconstituted solution: Solutions of

1235

over a period of at least 2 hours.

patients with impaired renal function. For

vancomycin is to be administered, or at least 2

hours when I gm of vancomycin is to be given.

vancomycin 50mg!ml. The reconstituted solution infusion 0.9% or Glucose i.v infusion S% to a concentration of not more than I Omg!ml. The resulting solution should be infused over a period of at least 60 minutes when SOOmg of

streptococci, enterococci, listeria monocytogenes, positive anaerobes including clostridium difficile

CII: Known hypersensitivity to teicoplanin or its any ingredients.

SIE: Teicoplanin is generally well tolerated.

Serious side-effects are rare. General side·effects

are gastfointestinal like nausea, vomiting, diarrhea; CNS associated with urticaria, rash, anaphylactic shock as well as hearing problems like vertigo, tinnitus and vestibular disorder may occur.

Precautions: Teicoplanin should be administered with caution in patients with renal insufficiency,

patients who require concurrent use of drugs

ANTIMICROBIAL DRUGS

QIMP-15 (204)

which have ototoxic &/or nephrotoxic properties.

Dose: By deep i_m inj_ or i_v infusion 2gm


initially then 19m every 6 hours for 2 days,

120mg (2.5 ml); 6 months to 5 yrs. 240mg (5ml);

and well-controlled studies of teicoplanin in pregnant women, therefore, this drug should be used during pregnancy only if clearly needed. Information about the excretion of teicoplanin in milk is not known.

followed by oral treatment for a further 5 days_

6 yrs. to 12 yrs. 480mg (10ml), all twice daily.

If injection is not

available, by mouth, 2gm (4

tab) on the first time there after 19m (2 tab) 4-

should be added slowly down the side wall of the vial of teicoplanin 200mg_ The vial should be rolled gently between the palms until the powder is completely dissolved_ During the rolling, we have to be cautious about the solution that it does not become foamy_ The' solution must not be shaken_ If foam formed then it should be allowed to stand for 15 minutes for the foam to be subsided_ The entire contents from the vial should be withdrawn slowly into a syringe_ The reconstituted solution can be administered

Preparation: May not be available

SULPHADIMIDINE2 1 SULPHADIMIDINE: TabletlInjection Ind: Specially for urinary tract infections. CII; SIE; Cautions: Same as sulphadiazine. Dose: By mouth, initially 2gm (4 tabs.) then 4gm daily in divided doses_ By i_m or Lv injection, 2gm initially, then 0_5-1gm every 6-8 hours_ Preparation: May not be available

SULPHASALAZINE21,60

either by i.m or i.v route. I.V injection may be administered by rapid injection over 3-5 minutes, or slowly over a 30 minutes infusion by diluting with 0_9% sodium chloride or Hartmann's solution or 5% dextrose etc. An Lm injection of teicoplanin should not exceed 3ml at a single site_

Patients with renal impairment: For patients with impaired renal function, reduction of dosage is not required until the fourth day of teicoplanin treatment. From the fourth day of treatment- in mild renal insufficiency teicoplanin dose should be halved either by administering the initial uriit dose every two days, or by administering half of this dose once a day when creatinine clearance is 406Omllmin; in severe renal insufficiency teicoplanin dose should be 1/3 the normal either by administering the initial unit dose

By i.m injection or i.v infusion, 960mg every 12 hours.

6 hourly for 7 days_

Dosage & admin: 3ml water for injection from the accompanying diluent water ampoule

wks. not recommended; 6 wks. to 5 months,

SULPHASALAZINE: Tablet Ind: Ulcerative colitis, Crohn's disease, rheumatoid arthritis. SIE: Nausia, headache, rash, fever, loss of appetite. Cautions: Impaired renal or hepatic function. Regular blood check and livar function test should be done. Dosage & admin: Adults: 2-4 tablets 4 times daily; maintenance, 4 tablets daily in divided doses_ Rheumatoid arthritis- initially 1 tablet daily for one week increasing by one each week to maximum 6 daily in divided doses_ Children: Under 2 years not recommended_ Over 2 years 40-60mglkg daily; maintenance, 20-30 mglkg daily.

.:. ACTRIM Tab. Globe

Cotrimoxazole 480mgltablet lOO's pack: 90.00 MRP .:. ACTRIM-DS Tab. Globe

Co-trimoxazole 960mg I tablet 1 00's pack: 1 40.00 MRP .:. ACTRlM Susp. Globe

Cotrimoxazole 240mg/5ml: suspension 60ml bot: 22.00 MRP .:. ALCOT Tab. Pacific

Cotrimoxazole 480mgltablet 100's pack: 100.00 MRP .:. ALCOT-DS Tab. Pacific

Co-trimoxazole 960mg (double strength)/tablet 100's pack: 200.00 MRP .:. ALCOT Susp. Pacific

Cotrimoxazole 240mgl5ml: suspension 60ml bot: 20.00 MRP .:. APCETRlM-DS Tab. A.P.C Pharma

Co-trimoxazole 960mg (double strength)/tablet 1 00's pack: 200.00 MRP .:. APCETRIM Susp. A.P.C Pharma

Co-trimoxazole 240mgl5ml: suspension 60ml bot: 20.00 MRP .:. APTRlM Susp. Apollo

Co-trimoxazole 240mg/5ml: suspension 60ml bot: 20.54 MRP .:. AVLOTRlN DS Tab_ ACI

Co-trimoxazole 960mg (double strength)1 tablet 100's pack: 200.00 MRP .:. AVLOTRIN Susp. ACI

Co-trimoxazole 240mg/5ml: suspension 60ml bot: 2 1 .49 MRP .:. BACTAZOL Tab. Sonear

Preparations: See under the 'drugs for chronic inflammatory bowel disease' in the Chapter- I of Gastro-intestinal drugs.

Co-trimoxazole 480mg/tablet 100's pack: 148.00 MRP

Drug inter: Teicoplanin should be administered

CO-TRIMOXAZOLE21 ,33

Co-trimoxazole 960mg/caplet 40's pack: 80.00 MRP

with caution in patients receiving concurrent nephrotoxic or ototoxic drugs such as aminoglycosides, amphotericin B, cyclosporine and frusemide.

CO-TRIMOXAZOLE: Tablet/Suspol Injection

Co-trimoxazole 240mgl5ml: suspension 60ml bot: 22.00 MRP

every third day or by administering 113 of the dose once a day when creatinine clearance is causes

Salt: Gel Preparation

gastrointestinal symptoms, such as- abdominal

tissue inflammations such as sprains, strains,

heartburn, nausea, 01 ulcers, vomiting. Other

Ind: Relief of pain in musculoskeletal & soft

bruises, traumatic inflammation of tendons, ligaments, muscles & joints; soft tissue

rheumatism, osteoarthrosis; periarthropathy etc.

CII: Hypersensitivity to diclofenac sodium or aspirin & other drugs opposing prostaglandin synthesis.

SIE: Small rashes, itching, redness or smarting at the site,

pain, constipation, diarrhea, dyspepsia, flatulence,

events include- abnormal renal function, anemia, dizziness, edema, elevated liver enzymes,

headache, increased bleeding time, pruritis,

rashes, tinnitus etc.

Precautions: Etodolac should be given with

caution in patients with severe hepatic reactions,

pre-existing asthma, fluid retention, hypertension or heart failure. If clinical sings and symptoms

Cautions: For NSAIDs asthma warning. Avoid

consistent with liver disease develop, or if

or broken skin.

rash etc.), it should be discontinued,

contact with eyes mucous membranes & injured

Use: Apply 3-4 times daily with gentle massage. Therapy should be reviewed after 14 days. .:. A-FENAC Gel Acme

Diclofenac diethylammonium salt 1 , 16% (equivalent to diclofenac sodium 1 % i.e 10mg/gm): gel preparation, IOgm tube: 1 3 .00 MRP

:. CLOFENAC Gel Square

•

Diclofenac diethylanamonium salt 1 . 1 6%

(equivalent to diclofenac sodium I % i.e 10mg/gm): gel preparation, IOgm tube: 12,90 MRP

:. EMOV Gel Edruc

•

Diclofenac diethylammonium salt 1 . 16%

(equivalent to diclofenac sodium 1 % i.e IOmg/gm): gel preparation.

2Sgm tube: 2S,00 IP

.:. MOOV Gel Proteety

Diclofenac diethylanamonium salt 1 . 16%

(equivalent to diclofenac sodium 1 % i.e IOmg/gm): gel preparation.

2Sgm tube: 4S.00 MRP

300mg x 30's pack: 240.00 MRP

.:. EDOPAIN 600 ER Tab. Incepta

I Ogm tube: 1 3 .00 IP

CII: Etodolac is contraindicated in patients with

DICLOFENAC DIETHYL AMMONIUM SALT21,54

.:. EDOPAIN Cap. Incepta

Etodolac BP 3OOmg/capsule

systemic manifestations occur (e,g. eosinophilia,


and well-controlled studies in pregnant women, It should be used in pregnancy only if the potential

benefit justifies the potential risk to the fetus. It is

not known whether etodolac is excreted in human milk. A decision should be made whether to

discontinue nursing or to discontinue the drug

taking into account the importance of the drug to

the mother.

Dosage & admin: Adults & over 18 years:

300mg capsule, 2 capsule (600mg) daily in 1-2

divided doses; Or, Etodolac 600mg ER tablet once daily.

Children: Below 18 years, nol recommended_ Drug inter: Reports suggest that NSAIDs may

ETORICOXIB 34 ETORICOXffi: Tablet

Etoricoxib is a non-steroidal anti-inflammatory

drug available as etoricoxib INN 60mg, 90mg & 1 20mg film-coated tablet.

Mode of action: It is a selective COX-2 inhibitor, Ind: Acute pain and inflammation, chronic

musculo-skeletal pain, osteoarthritis, rheumatoid

arthritis, acute gouty arthritis, primary

dysmenorrhoea, ankylosing spondylitis.

C1I: Patients with known hypersensitivity to

etoricoxib or any ingredient of the product.

Active peptic ulceration or gastro-intestinal

bleeding, severe hepatic dysfunction. Children

and adolescents under 16 years of age. Patients

with inflammatory bowel disease and severe congestive heart failure,

SIE: Common side effects are dizziness,

headache, gostro-intestinal disorders (e.g

abdominal pain, flatulence, heartburn), diarrhoea,

dyspepsia, nausea, asthenia, fatigue, flu-like

symptoms. Rare side effects are oedema, weight gain, anxiety, blurred vision, hypertension,

epistaxis, dyspnoea, constipation, vomiting, muscle cramps, chest pain,

Precautions: Decreased kidney function and

liver function, dehydration, hypertension, history

of heart failure, perforation, and people over 6S

years of age,

Pregnancy & lactation: Not recommended.

Dosage & admin: Adult and adolescent over

16 years: Arthritislosteoarthritis- 60mg once

daily; Rheumatoid arthritis- 90mg once daily; Acute gouty arthritis- 120mg once daily;

Analgesia, acute pain associated with dental surgery- 120mg once daily; Primary

dysmenorrhoea, chronic musculo-skeletal

pain, including chronic low back pain- 60mg once daily.

Drug inter: Warfarin, ACE inhibitors,

rifampicin, lithium, birth control pills, methotrexate, digoxin,

.:. COXIA Tab. ACI

Etoricoxib INN 6Omg, 90mg & 120mg/tablet 60mg x 30's pack: 2 10,00 IP

diminish the antihypertensive effect of ACE

90mg x 30's pack: 360,00 IP

consideration in patients taking NSAIDs

.:. COXITOR Tab. Beacon Etoricoxib INN 60mg & 90mg/tablet

inhibitors. This interaction should be given

concomitantly with ACE-inhibitors. As with other

120mg x 20's pack: 280.00 IP

NSAIDs, concomitant administration of etodolac

60mg x 30's pack: 2 10.00 MRP

potential of increased adverse effects.

.:. ECOX Tab. Alco Pharma

and aspirin is not recommended because of the

90mg x 20's pack: 240,00 MRP

H P R@ (" H P R@ ,rL1 115kg "

,, - 40mg ,, - 50mg ,, - 60mg ,, - 70mg

Drug inter: Please see the manufacturer's literature.

Note: For further information, please consult manufacturer1s literature. 1 00's pack: 2124.00 MRP

12. PROTECTION OF SKIN FROM SOLAR RADIATION .:. SPECTRABAN 19 Cream /SPECTRABAN ULTRA 28 Lotion StiefellUniMed81 SpectraBAN 19 Cream: This preparation contains- microfine zinc oxide coated 15%: 50gm cream in tube

SpectraBAN ULTRA 28 Lotion: This preparation contains- titanium dioxide 2%, butyl methoxydibenzoyl methane 2%, padimate 0.8%, oxybenzone 3%: 60ml lotion in bottle. Ind: Both offer skin protection against UVA, UYB & IR rays. These preparations are indicated as protective sun block in all patients who require a maximum protection sunscreen, including those with photodermatoses & reduced skin pigmentation. Precautions: Don't use in patients with known hypersensitivity to any of the ingredients. Avoid application to broken 'skin, eyes and mucous membrane.

Use & application: Apply SpectraBAN 19 cream or SpectraBAN Ultra 28 lotion carefully and evenly to areas to be exposed or protected only by light clothing. Allow 30 minutes before going out or swimming. A single application may give daylong protection but the product should be re-applied during prolonged period of sunning, swimming or excessive sweating. SpectraBAN 19 Cream 50gm tube: 629.39 MRP SpectraBAN Ultra 28 Lotion 60ml bot: 499.21 MRP

13. SHAMPOOS & OTHER SCALP PREPNS. I ANTI DANDRUFF PREPNS. KETOCONAZOLE26.I06 KETOCONAZOLE: Shampoo preparation

DRUGS ACTING ON THE SKIN Ketoconazole 2% (20mg/gm): shampoo preparation. Ind: Treatment and prophylaxis of infections in which the yeast Malassezia (previously called Pityrosporum) is involved, such as- Dandruff (Pityriasis capitis). Pityriasis versicolor (localized), Inflammatory skin condition with greasy, red & scaly areas (Seborrhoeic dermatitis) CII: Known hypersensitivity to ketoconazole or any of the excipients. SIE: As with other shampoos, a local burning sensation, itching, or contact dermatitis (due to irritation or allergy), may occur on exposed areas. Precautions: In patients who have been on prolonged treatment with topical corticosteroids, it is recommended that the steroid therapy be gradually withdrawn over a period of 2 to 3 weeks, while using Ketoconazole 2% shampoo to prevent any potential rebound effect. Pregnancy & lactation: Since ketoconazole is not absorbed through the skin after topical application, it is not contraindicated in pregnancy and lactation. Use & Admin: Treatment: Pityriasis versicolor once daily for 5 days. Seborrhoeic dermatitis and pityriasis capitis- twice weekly for 2 to 4 weeks. Prophylaxis: Pityriasis versicolor- once daily for 3 days during a single treatment course before the summer. Seborrhoeic dermatitis and pityriasis capitis- once every 1 or 2 weeks. Application: To use the Ketoconazole 2% shampoo, follow these steps: Use a small amount of water to wet the area where Ketoconazole 2 % shampoo is to be applied. Apply the shampoo to the affected scalp/skin and a large area around it. Use fingers to rub the shampoo until it forms lather. Leave the shampoo on scalp/skin for 5 minutes. Rinse the shampoo off scalp/skin with water Prophylactic or maintenance use: When the dandruff is under control, it can be stabilised by using once weekly with ketoconazole shampoo. Use normal shampoos on other occasions. .:. DANCEL Shampoo Incepta Ketoconazole 2% (20mg/gm): shampoo preparation. 60ml pack: 150.00 MRP 100ml pack: 230.00 MRP .:. NIZODER Shampoo UniMedlUniHealth Ketoconazole 2% (20mg/gm): shampoo preparation. 60ml pack: 150.00 MRP

14. ANTISEPTICS & SKIN DISINFECTANTS21 Antiseptics, skin disinfectants & cleansers in use are as following: 1. 2. 3. 4. 5. 6. 7.

Alcohols Normal saline Chlorhexidine & Chloroxylenol salts Cationic surfactants and soaps Chlorine, iodine & povidone-iodine Phenolics Astringents, oxidisers, and dyes

QIMP-lS (302)

DRUGS ACTING ON THE SKIN

Chlorhexidine & Chloroxylenol prepns.

30gm tube: 1 8.00 MRP

Chlorhexidine is available for antiseptic mouth

alcohol 20% w/v: solution for hand rub.

gluconate in different concentrations, such as 1 %

Chlorhexidine gluconate 0.5% w/v in isopropyl

SOml bot: 3 1 .00 MRP

CHLORHEXIDlNE2 1.33 CHLORHEXIDINE Antiseptic Prepns: CreamILotionlSolution

Chlorhexidine is a widely used antiseptic and

disifectant agent, available as cream, lotion, solution and hand rub in combination with.

cetrimide or isopropyl alcohol or alone.

Ind: General antisepsis and disinfectant and

cleansing purposes.

Precautions: Only for external use; in case of

solution dilute before use according to direction;

solution should not come in contact with eyes,

brain, meninges, or middle ear.

Accidental ingestion: Carry out a stomach

lavage with milk, egg white, gelatin or mild soap

Solution

.:. KEVIRUB Hand Rub Opsonin

2S0ml bot: 10S.00 MRP

.:. SAFETISOL Soln. Silva

Chlorhexidine gluconate 0.5% w/w in 70% isopropyl alcohol: solution for hand rub SOml bot: 30.00 MRP


.:. SAFETISOL Regular Silva

wasp or rinsing purpose as chlorhexidine (w/v) and 0.2% (w/v) solution.

Ind: Mouth wash as in gingivitis, cross infection

during oral surgery, oral thrush, inhibition of plaque formation.

Use: 2 tsf 2 times daily; keep one minute

in the mouth and gurgle each time; use one

month for gingivitis,

.:. ORALON Soln. ACI

Chlorhexidine gluconate 0.5% w/w in 70%

Chlorhexidine gluconate 0.2% w/v: solution for

dispenser).

1 00ml bot: 3S.00 fP

isopropyl alcohol: solution for hand rub (with 300ml (with dispenser): 1 2S.00 MRP

mouth wash or rinse.

300ml (refill): IOS.00 MRP '

.:. SAFWASH Soln. Medimet

Chlorhexidine gluconate BP solution.


.:. SAVLON Liquid ACI

CHLORHEXIDINE Dental Prepn: Dental gel

Chlorhexidine is available for antiseptic dental

use as chlorhexidine gluconate 1 % (w/w) gel

Chlorhexidine gluconate 0.3% w/v + cetrimide

preparation.

Use & application: Antiseptic solution:

S6ml bot: I S.00 IP

Use: see manufacturer's literature attached

disinfection prior to surgery & for routine use in the ward to reduce risk of cross-infection.

I litre: 1 10.00 1P

water.

Rapid skin cleansing solution for hand

For detail & other uses: See literature attached with the preparation. Cream preparations:

Adult & children: apply two or three times daily.

.:. CLENOL Cream Mystic

Chlorhexidine hydrochloride 0 . 1 % + cetrimide O.S%: antiseptic cream preparation.

30gm tube: 1 9 .00 MRP

:. G-ANTISEPTIC Soln. Gonoshas.

•

Chlorhexidine gluconate BP solution 1 00mi bot: I S . 1 7 MRP

.:. GERMISOL Hand Rub Square

Chlorhexidine gluconate O.S% w/w in 70%

isopropanol : solution for hand rub

SOml bot: 23.40 MRP

2S0ml bot: 79.2S MRP

:. HANDIRUB Hand Rub SK+F

•

Chlorhexidine gluconate O.S% w/v in isopropyl

alcohol 20% w/v: solution for hand rub.

SOml bot: 30.00 MRP


:. HEXISCRUB Soln. ACI

•

Chlorhexidine gluconate 4% solution 2S0ml bot: 100.00 IP

.:. HEXISOL Hand Rub ACI

Chlorhexidine gluconate O.S% w/w in 70%

isopropanol: solution for hand rub SOml bot: 3 1 .00 IP

2S0ml bot: lOS .00 IP

•:. HYGINOL Solution Millat

Chlorhexidine gluconate 0.3% w/v + cetrimide

3% w/v: solution.

SOml bot: 1 7.00 MRP

1 00ml bot: 26.00 MRP

.:. HYGINOL Cream Millat

Chlorhexidine hydrochloride 0. 1 % + cetrimide

O.S%: antiseptic cream preparation.

30gm tube: 22.00 MRP

3% w/v: solution.

1 1 2ml bot: 23.00 IP

Prices: Could not be revised.

.:. SAVLON (Hosp. conc.) ACI

Chlorhexidine glueonate soln. BP I .S% w/w &

certrimide BP I S % w/w, high concentration for

hospital use.

S lit. pack: 1 4 1 S .00 MRP

Prices: Could not be revised.

.:. ORALON Dental Gel ACI

Chlorhexidine gluconate 1 % w/v: gel preparation

30gm tube: 40.00 IP

CHLOROXYLENOU 1.33 .:. DETTOL Lotion Reckitt Benckiser

Chloroxylenol 1 .3% solution.

O.S%: antiseptic cream preparation.

obstetrics, antiseptic lubricant for vaginal

30gm tube: 22.00 IP

Use: wash with one table spoonful of dettol to

ISgm tube: 1 2 .00 IP

Prices: Could not be revised. .:. SEFTOL Soln. Skylab

Chlorhexidine gluconate BP & Cetrimide BP: solution

SOml bot: I S.00 MRP

1 00ml bot: 22.00 MRP

.:. SEPNIL Liquid Square

Chlorhexidine gluconate soln. BP I.S% w/v &

cetrimide BP 3% w/v.


1 00ml bot: 16.63 MRP

Prices: Could not be revised .

.:. SEPNIL (Hosp. conc.) Square

Chlorhexidine gluconate soln. BP I .S% w/w &

certrimide BP I S % w/w, high concentration for hospital use.

S lit. pack: 1 4 1 8.00 MRP

Prices: Could not be revised. .:. SEVDOL Lotion Seema

Chlorhexidine gluconate soln. BP & Cetrimide BP: lotion

SOml bot: I S .OO MRP


.:. XISOL Hand Rub Aristopharma

Chlorhexidin'e gluconate O.S% w/w in 70%

isopropyl alcohol: solution for hand rub

SOml bot: 30.00 MRP

2S0ml bot: 1 0S.00 MRP

Ind: disinfectant for skin and gloved hands;

examinations and on forceps; for hand antisepsis .

a tumbler of water (1 in 13) for urgent

application, undiluted dettol may be used but not in a sensitive skin. S6rnl bot: 1 8 .00 MRP 1 00ml bot:

7S0ml bot:

Prices: Could not be revised .

Iodine compounds: Povidone Iodine POVIDONE-IODINE2 1.85.1 4 1 POVIDONE-IODINE PREPNS: Cream/Oint! LotionlSolutionIPowderlPessaries

Povidone-iodine (polyvinylpyrrolidone- iodine), is a complex of iodine and an organic polymer,

povidone .

Action & Ind: The povidone-iodine polymerisation makes the 'complex' superior to ordinary

elemental iodine. It prolongs the germicidal

activity of iodine by liberating elemental iodine slowly, consequently it possesses a lower

toxicity than elemental iodine. Different studies

proved that povidone-iodine complex is effective

against a wide spectrum of pathogenic organisms

including both gram-postitive and gram-negative bacteria, fungi, protozoa, virus and yeasts. It is

.:. KEVILON Cream Opsonin

0.5%: antiseptic cream preparation.

with the preparation.

.:. SAVLON Cream ACI

Chlorhexidine hydrochloride 0 . 1 % + cetrimide

60gm tube: 30.00 MRP Chlorhexidine hydrochloride 0. 1 % + cetrimide

Ind: Use in dental & gum infection.

CHLORHEXIDINE Mouth WashlRinse:

also found active against bacterial spores; even it

is active in the presen4 points in any 2-week period. When a dose adjustment is necessary, it should be done at 4 week intervals & each adjustment in dose should be equal to 25 IU/kg. Maintenance dose: Maintenance dose must be individualized for each patients. In CRF patients not on dialysis, maintenance dose is 75 to ISO IU/kglweek. In patients undergoing dialysis, the median maintenance dose is 75 IU/kg 3 times per week. The maximum dosage should not exceed 200 IU/kg 3 times per week. If the hemoglobin exceeds 13gm/dl, the dose should be discontinued until the hemoglobin drops to 12gm/dl. The dose should be reduced by 25 % when treatment is resumed and then titrated to maintain hemoglobin level. When the treatment is stopped, the hemoglobin concentration falls by around 0.5gm/dl per week. Treatment of anemia in cancer patients on chemotherapy: St.;lrting dose: Adult: 150 IU/kg 3 times per week by s.c route. Pediatric: 25 to 300 IU/kg 3 to 7 times per week by s.c or i.v route. Dose Adjustment: If the response is not satisfactory, the dose should be increased to 300 IU/kg 3 times per week. If the hematocrit exceeds 40%, the dose should be stopped until the hematocrit falls to 36%. The dose should be reduced to 25 % when treatment is resumed & titrated to maintain the desired hematocrit. Prevention of anemia ofprematurity: The injection is administered s.c at a dose of 250 IU/kg body-weight 3 times per week_ Epoetin beta treatment should start as early as possible preferably by day 3 of life. Treatment should last for 6 weeks. Instructions for injection: S.C injection: A maximum volume of 1ml at one injection site,

QIMP.1S (319) and should generally not be exceeded.

Note: Consult manufacturer's

I.V injection: Over at least 1·2 minutes; in

.:. EPOETIN Inj. Incepta Epoetin 2000 IV, 3000 IV, 5000

bemodialysed patients, the injection should be

given after the dialysis session, into the fistula needle; do not administer by intravenous

infusion, or mix with other drugs. Store at 2° SoC; do not freeze or shake.

literature, if needed.

Epoetin alfa 2000 IV, 4000 IV & 10000 IV pre· filled syringes: for i. v or s.c injection. 2000 IV pre-filled syringe x l's: 1784. 1 1 MRP 4000 IV pre-filled syringe x l's: 3568.23 MRP 10000 IV pre·filled syringe x l 's: 5090.50 MRP

Overdose can cause rough skin, dry hair, enlarged liver, and a raised ESR and raised serum calcium and serum alkaline phosphatase concentrations.

osteoporosis; prophylaxis in recognisable risk of a vitamin·O deficiency disease; deficiency caused by intestinal malabsorption or chronic liver disease; abnormal calcium or phosphate metabolism; renal osteodystrophy; hypocal caemia of hypoparathyroidism; as adjunct in treatment of lupus vulgaris and T.B adenopathies. CII: Renal dysfunction; hypercalcaemia, metastatic calcification. SIE: Symptoms of overdosage include anorexia, lassitude,. nausea and vomiting, diarrhoea, weight loss, polyuria, sweating, headache, thirst, vertigo. and raised concentrations of calcium and phosphate in plasma and urine.

Dosage & admin: Adult: Oral- Prophylaxis,

4000 i.u. daily; in deficiency state, 50,000 to 300,000 i.u daily.

Injection: By deep i.m. injection, 150,000-

300,000 i.u monthly, increased to weekly in

acute deficiency states.

Children: Oral· tipto 50,000 i.u. daily. Injection' same as adult.

THIS CHAPTER INCLUDE: 1. Vitamin prepns. 1.1

Specific vitamin prepns.

1.2 Specific combined vitamin prepns. 1.3 Anti·oxidant multivitamin prepns. 1.4 Nonspecific multivitamin prepns.

2. Mineral & Mineral + Vitamin specific prepans.

2.1

Specific mineral prepns.

2.2 Specific minerai & vitamin combined prepns.

3. Multivitamin & multimineral combined prepns.

3.1 Nonspecific multivitamin &

multimineral combined prepns.

3.2 Super anti-oxidant vitamins & multimineral prepns.

3.3 Specialised multivitamin &

multimineral combined prepns.

4. Nutritional & Energy supple,?ent prepns. 4.1 Oral nutritional prepns. 4.2 Parenteral nutritional prepns.

1.1 Specific Vitamin Prepns.

Vitamin-A Prepns. VITAMIN_A21.26.3 3 VITAMIN-A: Tablet/Capsule/ Drop/ Injection

Vitamin A deficiency states, such as night blindness, impaired dark adaptation; lichen planus, acne, dry skin and other hyperkeratoses. Gastro·iritestinal disorders associated with disturbances in lipid absorption. Precautions: Hypervitaminosis-A can occur in infants and young childern given' excessive doses for long periods. Avoid use in early pregnancy. Ind:

10000 IV pre·filled syringe x l's: 3800.00 MRP .:. EPREX Inj. Janssen-CiiaglUniHealth

IV & 10000 IV pre-filled syringes: for i.v or s.c injection. 2000 IV pre-filled syring� x I's: 900.00 MRP 3000 IV pre-filled syringe x l 's: 1250.00 MRP 5000 IV pre·filled syringe x l 's: 1900.00 MRP

SIE:

DRUGS DISCUSSED IN

DRUGS USED IN ANAEMIAS & BLOOD DISORDERS

.:. A-FORTE Soft Cap. Globe

Vitamin A palmitate 50,000 i.u/capsule (soft gelatin). 100's pack: 190.00 MRP

Dosage & admin: By mouth: Adult & Child:

.:. A·VIT-l Soft Cap. Globe

Deficiency caused by intestinal malabsorption or chronic liver disease, upto 40,000 i.u. (Img)

Vitamin A palmitate 1,00,000 i.u/capsule (soft gelatin). 100's pack: 283.00 MRP .:. A-VIT-2 Soft Cap. Globe

Vitamin A palmitate 2,00,000 i.u/capsule (soft gelatin). 100's pack: 404.00 MRP .:. OVIT-A Cap. Opsonin

Simple Vitamin- D deficiency, 400 i.u (10mcg)

daily;

daily.

Renal osteodystrophy, upto 200,000 f.u. (5mg) daily.

Rickets & Osteomalacia, 1000-5000 i.u. daily. By Injection: In Rickets- for prevention: 200,000 i.u or 1

Vitamin A 50,000 i.u/capsule (soft gelatin). 100's pack: 1 90.00 MRP

ampoule every 4 months which may be

Vitamin A 50,000 i.u/capsule (soft gelatin). 120's pack: 230.40 MRP

Prevention should be started early and continue to the 5th year of life.

.:. RATINOL Forte Cap. Drug Inter.

.:. VIS-A SG Cap. Pacific

Vitamin A 50,000 i.u/capsule (soft gelatin). 100's pack: 190.00 MRP

·:· ·VITAMIN A FORTE Cap. Drug Inter.

increased to 400,000 i.u (2 ampoules). In

pregnancy· 1 ampoule at the 6th month.

In Rickets- curative: 1 ampoule every 2 weeks for one month and then

1 ampoule every 4 ":'onths or .600,000 i.u (3

ampoules) renewed some months later, as per the severity of the case.

Vitamin A palmitate 2,00,000 i.u/capsule (soft gelatin). 50's pack: 136.50 MRP

Hypocalcaemia caused tetany: Same as for

VITAMIN-D PREPNS .21

Renal Osteodystrophy: 200,000 i.u (1 ampoule)

Vitamin-D preparations include: 1. Ergocalciferol (calciferol or vitamin-D2)

2. Cholecalciferol (vitamin-D3) 3. Alfacalcidol (1 Cl - hydroxycholecalciferol)

4. Calcitriol (1, 25 dihydroxy cholecalciferol)

5. Dihydrotachysterol

ERGOCALCIFEROL(D2)! CHOLECALCIFEROL(D3 )2 1 .33.88 ERGOCALCIFEROL (D2)/

CHOLECALCIFEROL (D3) : Tablet/Capsule/

Solution/Dropllnjectin

Ind: Prophylaxis of rickets in mature infants; therapy of rickets & osteomalacia induced by vitamin 0 deficjency; supportive treatment in

preventing Rickets.

Osteoporosis & Osteomalacia: 200,000 i.u (1 ampoule) every 15 days for 3 months.

or more daily or,as advised by the physicians. .:. CALCIFEROL Inj. Renata

Calciferol injection Iml ampoule contains cholecalciferol (vitamin 03) BP 200,000 i.u. Iml amp (200.000 i.u/ml) x l 's pack: 90.00 MRP .:. CALClROL Inj. Drug Inter.

Calcirol injection I ml ampoule contains· cholecalciferol (vitamin 03) BP 200,000 i.u. I ml amp (200,000 i.u/ml) x I's pack: 120.00 MRP :. DEBOLIN Inj. Chemist

.

Oebolin injection Iml ampoule contains· cholecalciferol (vitamin 03) BP 200,000 i.u. Iml amp (200.000 i.u/ml) x 2's pack: 180.00 MRP .:. OSTE6-D Injectable & Oral Soln. Incepta

Injectable solution- Iml ampoule contains cholecalciferol (vitamin 03) BP 200,000 i.u. Oral solution- Iml contains cholecalciferol (vitamin 03) BP 200 i.u (or Smog); 15ml bottle. .

VITAMIN, MINERAL & NUTRITIONALS

Iml amp (200,000 i.u/ml) x l's pack: 90.00 MRP 15ml bot (200 i.u/ml) x I's pack: 75.00 MRP

.:. VIGANTOL Oil S()in, Popular Vigantol oil, 1m! solution' (30 drops) contains 0.5mg cholecalciferol, equivalent to 20,000 IV vitamin D3. l Oml dropping vial:·360.46 MRP •:. VITAMINE D3 B.O.N Lab. Doms Adrian! Maisha Health Oily solution of cholecalciferol 200,000 i.ull ml ampoule: injectable i.m or drinkable. Iml amp x l ' s pack: 135:00 TP

ALFACALCIDOV 1.73 .89 (I ex-hydroxycholecalciferol) ALFACALCIDOL: Capsule/Solution! Injection. Alfacalcidol or I u- hydroxycholecalciferol is the active form of vitamin-D3, which is formed in the kidney tissues by hydroxylation of D3. rnd: (i) Severe renal impairment requiring vitamin-D therapy (i.e renal osteodystrophy because, in this condition kidney fails to convert D3 into its active form i,e 1 u- hydroxycholecal ciferot: so it is prescribed)'. (ii) Hypoparathyroidism & other diseases associated with abnorm�1 vitamin-D metabolism. (iii) Postmenopausal & other osteoporosis. CII; SIE: See under ergocalciferol. Cautions: All patients receiving pharmaCOlogical doses of vitamin-D should have the plasma calcium concentration checked at intervals (initially weekly) & whenever nausea or vomiting are present� take care to ensure correct dose in infants; renal irrtpairment. Dosage & admin : By mouth or by i.v injection (over 30 seconds): adult. & child over 20kg initially Imcg daily (elderly 500 nanogram), adjusted to avoid hypercalcaemia; · maintenance, usually 0.2S-1mcg daily; Child under 20kg- initially 50 nanograms/kg daily; Neonate & premature Infant- initially 50100nanograms/kg daily, ' .:. ONE ALPHA C\,p. Leo Pharma/ Kapricorn Alfacalcidol (l u-hydroxycholecalciferol) 0.25mcg/capsule. Dosage & admin: Adult and Child over 20kg initially 1mcg daily (elderly 500 ngm), adjusted to avoid hypercalcaemia; maintenance, usually 0.'25-1mcg daily. Child under 20kg-. initially 50 ngm/kg daily. Neonate & premattire infants- initially . 50-100 ngm/kg daily: 100's pack: 1 1 95 .00 MRP

CALCITRIOLZ I .50 (1,25-dihydroxycholecalciferol) CALCITRIOL (1,2S-Dihydroxycholecalci ferol): CapsuleJlnjection Calcitriol (or 1,25-dihydroxycholecalciferol) is available as 0.25mcg/cap;;ule for oral ingestion and l mcgllm! ampoule for injection. Ind: Oral capsule�' Requiring vitamin-D therapy in patients with severe renal impainnent i.e renal osteodystrophy (vitamin-D requires

QIMP-15 (320)

hydroxylation by the kidney to its active form i.e 1 -hydroxycholecalciferol, or 1,25dihydroxycholecalciferol so, in severe renal impairment it is prescribed); postmenopausal osteoporosis. Parenteral injection: Hypocalcaemia in dialysis patients with chronic renal failure. CII; SIE; Cautions: See above under ergocalciferol. Dosage & admin: By mouth: Renal osteodystrophy: Adult, initially 0.25mcg daily or on alternate days, increased if necessary in steps of 0.2Smcg at ' intervals of 2-4 weeks;usuaI dose O.S-lmcg daily; child, not established. Established postmenopausal osteoporosis: 0.2Smcg twice daily (monitor plasma calcium and creatinine level if possible). By injection: Hypocalcaemia in dialysis patients with chronic renal failure- by i.v injection or through dialysis catheter after haemodialysis, initially 500 nanograms (approx_ 10 nanograms/kg) 3 times a week, increased if necessary in steps of 250-500 nanograms at intervals of 2-4 weeks; usual dose 0.5-3mcgs 3 times a week. Child: Not established.

.:. CALOREN I.V Inj. ACI Calcitriol ( l ,25-dihydroxycholecalciferol) l mcgll ml ampoule: i.v injection Iml amp x I's pack: 155.00 IP .:. CALTROL Cap. Pacific Calcitriol ( l ,25-dihydroxycholecalciferol) 0.25mcg/capsule. 0.25mcg x 30's pack: 240.00 MRP .:. COLITROL Cap. Incepta Calcitriol (I ,25-dihydroxycholecalciferol) 0.25mcglcapsule. 0.25mcg x 30's pack: 300.00 MRP

.:. COLITROL Inj. Incepta Calcitriol ( I ,25-dihydroxycholecalciferol) I mcgllm! ampoule: i.v injection Iml amp x I's pack: 155.00 IP .:. DEBOLIN Inj. Chemist Calcitriol (I ,25-dihydroxycholecalciferol) I mcg/l m! ampoule: injection 1m! amp x I's pack: 1 20.00 MRP .:. DICALTROL Cap. Drug Inter. Calcitriol ( l ,25-dihydroxycholecalciferol) 0.25mcglcapsule. 0.25mcg x 50's pack: 350.00 MRP .:. LIQUICAL Cap. Beacon Calcitriol (I ,25-dihydroxycholecalciferol) 0.25mcglcapsule. 0.25mcg x 30's pack: 300.00 MRP •:. ROCALTROL Cap_ Roche Calcitriol (I ,25-dihydroxycholecalciferol) 0.25mcg & 0.50mcg/capsule. 0.25mcg x 30's pack: 390.30 MRP

VITAMIN A+D / VITAMIN A+D+E21. 33 .:. COD LIVER OIL Cap. Drug Inter. Vitamin A, D & E soft gelatin capsule. l 20's pack: 1 2 1 .00 MRP .:. CODVIT Cap. Opsonin Cod liver oil capsule, contains vitamin A 600 i.u & vitamin D3 85 i.u: soft gelatin capsule 100's pack: 100.00 MRP

.:. SEVENSEAS COD LIVER OIL British Cod Liver Oil Ltd. Vitamin A & 0 containing fish cod liver oil. 1 70m! & 450ml bottle. Dose: 1 tsf 3 times daily. 1 70ml x 12's pack: 474.50 MRP 450ml pack: 86.94 MRP Prices: Could not be revised. .:. SEVENSEAS (High Potency) Cap_ B.C.L.O Ltd. High potency vitamin A & D containing fish liver oil: capsule. 100's x l 2 bot: 647.20 MRP 500's x l 2 bot: 2 1 74.50 MRP Prices: Could not be revised.

MULTIVITAMIN + COD LIVER OIL PREPNS.26. 34.139 MULTIVITAMIN + COD LIVER OIL PREPN: Syrup This is a special preparation of multivitamin, comprising vitamin A, D, B I , B2, B6, C, E, nicotinamide & cod liver oil. These eight essential vitamins & cod liver oil, which adequately replenish the deficiency of vitamins & maintains the proper growth & resistance of body against diseases. These are also essential for normal metabolic functions including hematopoiesis. Compo Each 5ml contains- vitamin A (as vitamin A propionate) BP 2000 i.u, vitamin D (as cholecalciferol) BP 200 i.u, vitamin B I (as thiamine hydrochloride) BP 0.70mg, vitamin B2 (as riboflavine sodium phosphate) BP 0.85mg, vitamin B6 (as pyridoxine hydrochloride) BP 0.35mg, vitamin C (as ascorbic acid) BP 1 7.50mg, vitamin E (as alpha tocopherol acetate) BP 1 .50 i.u, nicotinamide BP 9 .00mg, & cod liver oil BP l OOmg. Ind: To supply the increased need of growing child; prevention of deficiency syndromes; improvement of child appetite, supplement of multivitamin for the malnourished patients during rehabilitating period. CII: This product is contraindicated in patients with a known hypersensitivity to any of the ingredients. SIE: Generally well tolerated. However, a few allergic reactions may be seen. Precautions: The multivitamin ingredients may accumulate in the body, which may cause danger. SO� it should not use over dosage or not use continuously. Pregnancy & lactation: Recommended. Dosage & admin: Infant (1-12 months): 112 tsf daily; Child (1-4 yrs): 1 tsf daily; Child (4 yrs up): 1112 tsf daily. Drug inter: No such drug interactions have been reported.

M ixavif

Cod liver oil with Multivitamin syrup

...to nourish healthy living

SK·F

QIMP-15 (321)

.:. AQUAVIT Syp_ Somalec

This is a special preparation of multivitamin comprising vitamin A, D, B1, B2, B6, C, E, nicotinamide & cod liver oil: syrup Comp: See above under the text.

100ml'bottle: 80.00 MRP .:. KIDDI Syp. Renata

.:. BEXTRAM KIDZ Syp. Beximco

This is a special preparation of multivitamin comprising vitamin A, D, B 1 , B2, B6, C, E, nicotinamide & cod liver oil: syrup 50ml bottle: 50.00 MRP 100ml bottle: 80.00 MRP 200ml bottle: 140.00 MRP

Dose & admin: See above under the text.

This is a special preparation of multivitamin comprising vitamin A, D, B1, B2, B6, C, E, nicotinamide & cod liver oil: syrup 100ml bottle: 80.00 MRP

Dose & admin: See above under the text_

l OOml bottle: 80.00 MRP

This is a special preparation of multivitamin comprising vitamin A. D, B l , B2, B6, C, E, nicotinamide & cod liver oil: syrup Comp: See above under the text. 100ml bottle: 80.00 MRP

.:. CNV Syp. Delta

This is a special preparation of multivitamin comprising vitamin A, D, B I, B2, B6, C, E, nicotinamide & cod liver oil: syrup Comp: See above under the text. Dose & admin: See above under the text.

60ml bottle: 45.00 MRP 10QmI bottle: 80.00 MRP

.:. CODLIVIT Syp. Silva

This is a special preparation of multivitamin comprising vitamin A, D, B I , B2, B6, C, E, nicotinamide & cod liver oil: syrup Comp: See above under the text. Dose & admin: See above under the text.

lOOml bottle: 80.00 MRP 200ml bottle: 150.00 MRP .:. COD PLUS Syp. Apex

This is a special preparation of multivitamin comprising vitamin A, D, B I, B2, B6, C, E, nicotinamide & cod liver oil: syrup Comp: See above under the text. Dose & admin: See above under the text.

100ml bottle: 80.00 MRP 200ml bottle: 145.00 MRP

.:. CODVITA Syp. Amico

This is a special preparation of multivitamin comprising vitamin A, D, B I , B2, B6, C, E, nicotinamide & cod liver oil: syrup Comp: See above under the text. Dose & admin: See above under the text.

100ml bottle: 80.00 MRP

.:. E-COD Syp. Novo Healthcare

This is a special preparation of multivitamin comprising vitamin A, D, B 1 , B2, B6. C, E, nicotinamide & cod liver oil: syrup 100ml bottle: 80.00 MRP \ .:. FILWEL KIDS Syp. Square

This is a special preparation of multivitamin comprising vitamin A, D, B I, B2, B6, C, E, nicotinamide & cod liver oil: syrup 100ml bottle: 80.00 MRP 200ml bottle: 145.00 MRP

.:. MIXAVIT Syp. SK+F

.:. MULTI SEAS Syp. General

This is a special preparation of multivitamin comprising vitamin A, D, B I , B2, B6, C, E, nicotinamide & cod liver oil: syrup 100ml bottle: 80.00 MRP 200ml bottle: 145.00 MRP .:. NINE SEAS Syp. Aristopharma

This is a special preparation of m'ultivitamin comprising vitamin A, D, B 1 , B2, B6, C, E, nicotinamide & cod liver oil: syrup 100ml bottle: 80.00 MRP 200ml bottle: 145.00 MRP .:. PEDIAVIT Syp. UniMedlUniHealth

This is a special preparation of multivitamin comprising vitamin A, D, B 1 , B2, B6, C, E, nicotinamide & cod liver oil: syrup 100ml bottle: 80.00 MRP .:. REVAM KIDS Syp. Navana

This is a special preparation of multivitamin comprising vitamin A, D, B I , B2, B6, C, E, nicotinamide & cod liver oil: syrup 50ml bottle: 45.00 MRP 100ml bottle: 80.00 MRP .:. SEAS Plus Syp. Globe

This is a special preparation of multivitamin comprising vitamin A, D, B I , B2, B6, C, E, nicotinamide & cod liver oil: syrup 100ml bottle: 80.00 MRP 200ml bottle: 145.00 MRP .:. SUPRA COD Syp. Drug Inter.

This is a special preparation of multivitamin comprising vitamin A, D, B I , B2, B6, C, E, nicotinamide & cod liver oil: syrup 100ml bottle: 80.00 MRP .:. VITAGROW Syp. Incepta

This is a special preparation of multivitamin comprising vitamin A, D, B I, B2, B6, C, E, nicotinamide & cod liver oil: syrup 1 00ml bottle: 80.00 MRP .:. VITA SEAS Syp. Medicon

.:. GOLD KID Syp. Orion

This is a special preparation of multivitamin comprising vitamin A, D, B I , B2, B6, C, E, nicotinamide & cod liver oil: syrup 100ml bottle: 80.00 MRP

.:. HEPTASEAS Syp. ACI

This is a special preparation of multivitamin comprising vitamin A, D, B I , B2, B6, C, E, nicotinamide & cod liver oil: syrup 100mi bottle: 75.00 MRP

This is a special preparation of multivitamin comprising vitamin A, D, B I, B2, B6, C, E, nicotinamide & cod liver oil: syrup 100ml bottle: 80.00 MRP This is a special preparation of multivitamin comprising vitamin A, D, ai, B2, B6, C, E, nicotinamide & cod liver oil: syrup lOOml bottle: 80.00 MRP .:. JUNIVIT Syp. Ibn Sina

This is a special preparation of multivitamin comprising vitamin A, D, B 1 , B2, B6. C, E, nicotinamide & cod liver oil: syrup

.:. VITCOD Syp. Aleo Pharma

.:. ZOVIA KIDS Syp. Opsonin

This is a special preparation of multivitamin comprising vitamin A, D, B I, B2, B6, C, E, nicotinamide & cod liver oil: syrup 100ml bottle: 80.()0 MRP Vitamin B Group


THIAMINE (8 1)21.3 3 THIAMINE (BI): Tablet/lnjection. Ind: Beri-beri; Neuritis (such as in diabetes,

poisoning etc), Polyneuritis after infectious diseases; mental disorders associated with alco hol.ism, wernickes syndrome; anorexia nervosa.

Dosage & admin: Adult: Daily dietary requirement, 3 to 6mg; Neuritis, 25 to 100mg daily by inj. followed by 10-50 mg daily orally. In acute deficiency, 100-200 mg daily by i.m or i.v inj. followed by oral therapy. Neuralgias, 50.l50mg by inj. every alternate day. Anorexia, Same as neuritis Child: 5·20 mg daily orally and parenterally. .:. A-BI Tab. Acme

Thiamine hydrochloride 100mg/tabiet 100's pack: 74.00 MRP .:. AVITRON·V Tab. Beximco

Thiamine hydrochloride 100mg/tabiet 250's pack: 185'.00 MRP .:. BEOVIT Tab. Square.

Thiamine hydrochloride 100mg/tablet 250's pack: 1 85.00 MRP .:. BERIN Tab. GlaxoSmithKline

Thiamine hydrochloride 100mg/tabiet 250's pack: 1 87.50 MRP .:. B·ONE Tab. Alco Pharma

Thiamine hydrochloride 100mgltabiet 100's pack: 74.00 MRP .:. G·VITAMIN·Bl Tab. Gonoshasthaya

Thiamine hydrochloride' 100mg/tablet 100's pack: 61 .00 MRP .:. KVIT·TH Tab. Chemico

Thiamine hydrochloride 100mg/tabiet 100's pack: 74.00 MRP .:. NEOVIT Tab. Skylab

Thiamine hydrochloride 100mg/tablet 100's pack: 72.00 MRP .:. NEUROVIT Tab. Medimet

Thiamine hydrochloride 100mg/tabiet 100's pack: 74.00 MRP .:. NEUROVIT Inj. Medimet

Thiamine hydrochloride 25mg/lml ampoule: injection 10 amps pack: 39.60 MRP .:. RENERV Tab. Gaco

Thiamine hydrochloride 100mg/tabiet . 100's pack: 74.20 MRP .:. RENERV Inj. Gaco

Thiamine hydrochloride 25mgilml ampoule: injection I ampoule: 3.03 MRP .:. THAI· 1 Inj. Edruc

Thiamine hydrochloride 25mg/lml ampoule: injection 10 amps pack: 35.00 MRP .:. THIABIN Tab. Medicon

Thiamine hydrochloride. 100mgitablet. 300's pack: 225.00 MRP .:. THIAMINE Tab. Seema

Thiamine hydrochloride 100mgltablet. 250's pack: 185,00 MRP .:. THIANOMIN Inj. Rephco

.

Thiamine hydrochlorid"J25mgilml ampoule: injection 25 amps pack: 65.00 MRP .:. THIASON Tab. Jayson

Thiamine hydrochloride 100mgitablet.


QIMP-lS (322)

1 00's pack: 74.00 MRP .:. THIASON Inj. Jayson Thiamine hydrochloride 1 00mg/l ml; Iml ampoule & IOml vial: injection 10 amps pack: 35.40 MRP I Oml vial: 1 6. 17 MRP

.:. RIBOTAB Tab. Ziska Riboflavine 5mg/tablet. 500's pack: 105.00 MRP

.:. THIATAB Tab. Mystic Thiamine hydrochloride 1 00mg/tablet. 1 00's pack: 73,00 MRP

.:. RIBOVIT Tab. Gaco Riboflavine 5mg/tablet. 1 00's pack: 22.53 MRP

.:. THIOBION Tab. Aristopharma Thiamine hydrochloride 100mg/tabiet 100's pack: 72.00 MRP

.:. RIVIN Tab. Supreme Riboflavine 5mg/tablet. 500's pack: 50.00 MRP

.:. THIOLEX Tab. Globe Thiamine hydrochloride 100mg/tablet. 100's pack: 73.00 MRP

NICOTINIC ACID (B3)21 ,39

•:. THIOSINA Tab. Ibn Sina Thiamine hydrochloride 1 00mg/tabiet 200's pack: 148.00 MRP

.:. THIOVIT Tab. Pharmadesh Thiamine hydrochloride 100mg/tabiet 100's pack: 80.00 MRP •:. TONE Tab. Orion Thiamine hydrochloride 100mg/tabiet 100's pack: 73,00 MRP

.:. VITA-l Tab. Pacific Thiamine hydrochloride 100mg/tabiet 100's pack: 73.00 MRP •:. VITAMIN-Bl Inj. Chemist Thiamine hydrochloride 25mg/lml ampoule: injection 25mg x 50 amps pack: 1 2 1 .00 MRP

RIBOFLAVINE (B2)21 , ll RIBOFLAVINE (B2): Tablet. Ind: Angular stomatitis, cheilosis, glossitis; sore throat; seborrhoeic dermatitis; photophobia, anaemia, neuropathy etc. Dosage: Adult & Child: 5 to 10 mg 2-3 times daily .:. G- VITAMIN-B2 Tab. Gonoshasthaya Riboflavine 5mg/tablet. 100's pack: 13.00 MRP .:. RIBOFLAVIN Tab. Medicon Riboflavine 5mg/tablet. 500's pack: 60.00 MRP .:. RIBOFLAVIN Tab. Rasa Pharma Riboflavine 5mg/tablet. 500's pack: 85.00 MRP •:. RIBOFLAVIN Tab. Skylab. Riboflavine 5mg/tablet. 500's pack: 45.00 MRP 1 000's pot: 90.00 MRP .:. RIBOFLAVINE Tab. Amico Riboflavine 5mribotab gltablet. 500's pack: 65.00 MRP •:. RIBOFLAVINE Tab. Pharmadesh Riboflavine 5mg/tablet. 500's pack: 105.00 MRP 1000's pack: 21 0,00 MRP •:. RIBOSEEM Tab. Ibn Sina Riboflavin 5mg/tablet 500's pack: 60.00 MRP

.:. RIBOSINA Tab. Ibn Sina Riboflavin 5mg/tablet 500's pack: 1 15.00 MRP .:. RIBOSON Tab. Jayson Riboflavine 5mg/tablet. 500's pack: 1 1 5,00 MRP

.:. RIBOVIT Tab. Aexim Riboflavine 5mg/tablet. 500's pack: 60.00 MRP

NICOTINIC ACID (B3): Tablet Ind: Prevention and treatment of pellagra, as vasodilator in peripheral vascular disease, vincenfs infection, hypercholesterolaemia, hypertriglyceridaemia. CII: Pregnancy, breast feeding . SIE: Flushing, dizziness, palpitations, pruritus, nausea, vomiting; rarely impaired liver function and rashes, Caution: Diabetes mellitus, gout, liver diseases, peptic ulcer. Dose: 2-3 tabs. daily or 100-200mg. daily. .:. NICOSON Tab. Jayson Nicotinic acid 50mgltablet 50mg x 1 00's pack: 35,00 IP

PYRIDOXINE (B6} 2 1,33 PYRIDOXINE (B 6): Tablet Ind: Peripheral neuritis, isoniazid-induced peripheral neuritis; premenstrual syndrome; pregnancy; radiation sickness; idiopathic sideroblastic anaemia, B6 deficiency anaemia; other deficiency states and convulsion in infants. CII: In patients receiving levodopa Cautions: Drug interaction with levodopa, but does not occur if dopa decarboxylase inhibitor also given. Dosage & admin: Adult: Neuritis & dificiency states, 20-2Smg upto 3 times daily Isoniazid neuropathy, prophylaxis 10mg daily. Idiopathic sideroblastic anaemia, 100-400 mg daily in divided doses. Premenstrual syndrome, SO-lOOmg daily. Child: Convulsions, 20-100mg daily. •:. G- VITAMIN-B6 Tab. Gonoshasthaya Pyridoxine hydrochlor 25mgltablet. 100's pack: 17,00 MRP

.:. PYROL Tab. Jayson Pyridoxine hydrochlor 25mg/tablet. 100's pack: 19.22 IP .:. PYROVIT Tab. Pharmadesh Pyridoxine hydrochlor 20mg/tablet 250's pack: ]0.00 MRP .:. PYROXIN Tab. Gaco Pyridoxine hydrochlor 20mg/tablet 100's pack: 19.21 MRP

CYANOCOBALAMINE (BI2) See above under 'megaloblastic anaemia',

VITAMIN B 1 + B2 + B02 1,33,90 VITAMIN B 1 + B2 + B 6 : Injection

This is a special combination product of vitamin B 1 , B 2 and B 6 . 1t is available as 2ml ampoule for injection. Each 2ml ampoule contains- thiamine (B 1 ) BP 100mg, riboflavine (B2) 50mg & pyridoxine (B6) 1 00mg, Ind: Neuritis accompanying alcoholism and pregnancy, optic neuritis, trigeminal neuralgia, lumbago sciatica, peripheral neuritis due to isoniazid therapy, facial paralysis, disorders of the peripheral circulation . CII: Anaphylactic reaction; patients receiving levodopa. Caution: See under individual drug (B 1 , B2 & B6).

Dose: In severe cases, one ampoule daily until all the symptoms disappear. For milder cases, one ampoule 2-3 times a week. .:. NERVIN Inj. Jayson Thiamine (BI) 1 00mg + Riboflavine (B2) 50mg + Pyridoxine (B6) 100mg/2ml ampoule: injection I O's pack: 45.20 MRP .:. NUROBIX Inj. Chemist Thiamine (B 1 ) 1 00mg + Riboflavine (B2) 50mg + Pyridoxine (B6) 100mg/2ml ampoule: injection 3 amps pack: 2 1 .75 MRP .:. RENERV Plus Inj. Gaco Thiamine (BI) 1 00mg + Riboflavine (B2) 50mg + Pyridoxine (B6) 1 00mg/2ml ampoule: injection 4's pack: 54.00 MRP .:. REOPLEX Forte Inj. Rephco Thiamine (BI) 100mg + Riboflavine (B2) 50mg + Pyridoxine (B6) 100mg/2ml ampoule: injection 10 amps pack: 55.00 MRP .:. TI-EDIPLEX Inj. Edruc Thiamine (BI) 1 00mg + Riboflavine (B2) 50mg + Pyridoxine (B6) 1 00mg/2ml ampoule: injection 6 amps pack: 43.20 MRP

VITAMIN B 1 + B6 + B 1226, 1 29 VITAMIN B 1 + Bo + B 12 : Tablet/Injection This is a special combination product of vitamin B I , B 6 and B". These vitamins are indispensable

for a normal course of the nervous metabolism in the,human body. The deficiency of these three vitamins leads to a syndrome of various chronic painful conditions . The product is available in tablet & injection form. Comp: Each tablet contains- thiamine mononitrate (B 1 ) BP 1 00mg, pyridoxine hydrochloride (B6) BP 200mg & cyanocobalamin (B 1 2) BP 200mcg . Each injection ampoule contains- thiamine mononitrate (B 1) BP 1 00mg, pyridoxine hydrochloride (B6) BP 1 00mg and cyanocobalamin (B 12) BP 1 mg . Mode of action: These three vitamins- thiamine, pyridoxine and cyanocobalamin play an essential role as co-enzyme in cellular biochemical metabolism in the nervous system. Thus, the combination normalizes metabolic condition of nerve cells & improves their condition. This combination also supports the regeneration of nerve fibers & myelin sheath, & the natural

QIMP-15 (323)

repair mechanism. Ind: This combined product is indicated where a deficiency of the relevant vitamins exists, such as: diabetic neuropathy, back pain, lumbago, sciatica, spinal pain, peripheral neuralgia, trigeminal neuralgia, intercostal neuralgia, myalgia, cervical syndrome, & shoulder-arm syndrome. CII: Should not be-used in the patients on levodopa therapy and hypersensitivity to any of the active ingredients. SIE: Generally well tolerated. However, a few allergic reactions may be seen. Precautions: Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord. Cyanocobalamin is not a suitable form of vitamin B 12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin. Pregnancy & lactation: Oral tablet form is recommended but injectable preparation is not recommended due to presence of benzyl alcohol. Dosage & admin: Oral preparation may be administered in a dose of 1-3 tablets daily or as directed by the physician_ Injections are preferably to be given by deep intramuscularly (as in intraglu!eal muscles)_ In severe cases 1 ampoule daily until the acute symptoms subside_ For milder cases and follow up therapy 2 to 3 ampoules per week_ Drug inter: No such drug interactions have been reported.

SK·F Vitamin B., B.andB.. Tablet & 1M injedion

t· �

Vitamin

B combination i : pain solution ..

.:. BOST Tab, General Thiamine mononitrate (B 1 ) BP I OOmg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 30's pack: 1 20.00 MRP .:. DEBION Tab_ Delta Thiamine mononitrate ( B 1 ) BP 1 00mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 30's pack: 1 20.QJ MRP .:. D-VITAL Tab_ Doctor's Thiamine mononitrate (B 1 ) B P 1 00mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (BI2) BP 200mcg/tablet. · 40's pack: 1 60.00 MRP .:. EDRUPLEX Tab_ Edruc Thiamine. n)On"nitrate (B·,) B P 1 00mg,


pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (BI2) BP 200mcg/tablet. 30's pack: 1 20.00 MRP .:. EDRUPLEX Inj_ Edruc Thiamine mononitrate ( B 1 ) BP 1 00mg, . , pyridoxine hydrochloride (B6) BP 100mg and cyano.cobalamin (B 12) BP I mg/3ml ampOUle: i.m injection. 3ml amp x 3's pack: 75.00 MRP •:. KVIT-N Tab_ Chemico Thiamine mononitrate (B 1 ) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B I 2) BP 200mcg/tablet. 30's pack: 1 20.00 MRP .:. KVIT-N Inj_ Chemico Thiamine mononitrate (B 1) BP 100mg, pyridoxine hydrochloride (B6) BP 100mg and cyanocobalamin (BI2) BP I mg/3ml ampoule: i.m injection. 3ml amp x I 's pack: 25.00 MRP .:. MEDIBION Tab, Medicon Thiamine mononitrate (B 1 ) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 30's pack: 1 20.00 MRP .:. MIOVIT Tab, Somatec Thiamine mononitrate (B 1 ) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (BI2) BP 200mcg/tablet. 30's pack: 120.00 MRP .:. MYELIN Tab, Opsonin Thiamine mononitrate (B 1 ) BP 1 00mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (BI2) BP 200mcg/tablet. 50's pack: 200.00 MRP .:. MYELIN Inj, Opsonin Thiamine mononitrate (B 1) BP 1 00mg, pyridoxine hydrochloride (B6) BP 1 00mg and cyanocobalamin (BI2) BP I mg/3ml ampOUle: i.m injection. 3ml amp x 5's pack: 1 25.00 MRP .:. MYOLIN Tab. Beximco Thiamine mononitrate (B 1 ) BP 1 00mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (BI2) BP 200mcg/tablet. 30's pack: 120.00 IP .:. NEOBION Tab. Aristopharma Thiamine mononitrate (B 1 ) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 30's pack: 200.00 MRP .:. NEOBION Inj. Aristopharma Thiamine mononitrate (B 1 ) BP 1 00mg, pyridoxine hydrochloride (B6) BP 100mg and cyanocobalamin (BI2) BP I mg/3ml ampoule: i.m injection. 3ml amp x IO's pack: 250.00 MRP

cyanocobalamin (BI2) BP 2oomcg/tablet. 30's pack: 120.00 MRP .:. NEUBIN Inj. Ziska Thiamine mononitrate ( B 1 ) BP 100mg, pyridoxine hydrochloride (B6) BP 100mg and cyanocobalamin (B 12) BP I mg/3ml ampoule: i.m injection. 3ml amp x IO's pack: 200.00 MRP .:. NEUREX-B Tab. Silva Thiamine mononitrate ( B 1 ) BP 100mg • pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcgitablet. 50's pack: 200.00 MRP .:. NEURALGIN Tab. Ibn Sina Thiamine mononitrate (B 1 ) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B12) BP 200mcg/tablet. 30's pack: 1 20.00 MRP .:. NEURALGIN Inj. Ibn Sina Thiamine mononitrate ( B 1 ) BP 100mg, pyridoxine hydrochloride (B6) BP l oomg and cyanocobalamin (BI2) BP I mg/3ml ampoule: i.m injection. 3ml amp x 10's pack: 250.00 MRP .:. NEUREX-B Tab. Silva Thiamine mononitrate (B 1 ) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 30's pack: 1 20.00 MRP .:. NEURO-B Tab. Square Thiamine mononitrate (B 1 ) BP 1 00mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 30's pack: 1 20.00 MRP .:. NEURO-B Inj. Square Thiamine mononitrate (B 1 ) BP 100mg, pyridoxine hydrochloride (B6) BP 1 00mg and cyanocobalamin (BI2) BP I mg/3ml ampoule: i.m injection. 3ml amp x 10's pack: 250.00 MRP .:. NEUROBEST Tab. Renata Thiamine mononitrate (B 1 ) BP 1 00mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 30's pack: 120.00 MRP .:. NEUROBEST Inj. Renata Thiamine mononitrate (B 1 ) BP IOOmg, pyridoxine hydrochloride (B6) BP l oomg and cyanocobalamin (B 12) BP Img/3ml ampOUle: i.m injection. 3ml amp x IO's pack: 250.00 MRP .:. NEU VITAL Tab. UniMedlUniHealth Thiamine mononitrate (B I ) BP 1 00mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 30's pack: 1 20.00 MRP

.:. NERVO-B Tab. Apex TThiamine mononitrate (B 1 ) BP 1 00mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 50's pack: 200.00 MRP

.:. NUGESIC Tab. Orion Thiamine mononitrate (B I ) BP 1 00mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 30's pack: 1 20.00 MRP .:. NUGESIC Inj. Orion Thiamine mononitrate ( B 1 ) BP l oomg, pyridoxine hydrochloride (B6) BP 100mg and cyanocobalamin (B12) BP Img/3ml ampOUle: i.m injection. 3ml amp x 1 0's pack: 250.00 MRP

.:. NEUBIN Tab. Ziska Thiamine mononitrate (B 1 ) BP 100mg; pyridoxine hydrochloride (B6) BP 2Q mg and

.:. NUROBIX Plus Inj. Chemist Thiamine mononitrate ( B 1 ) BP 1 00mg, pyridoxine hydrochloride (B6) BP 100mg and

.:. NERVA Tab. Pharmadesh Thiamine mononitrate ( B 1 ) BP 1 00mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 30's pack: I O�.OO MRP

�


cyanocobalamin (B 12) BP I mgl3m! ampoule: i.m injection. 3ml amp x 5's pack: 125.00 MRP .:. N-VIT Tab. Syntho

Thiamine mononitrate (BI ) BP l oomg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (BI2) BP 200mcg/tablet. 30's pack: 1 20.00 MRP

QIMP-15 (324)

50's pack: 200.00 MRP .:. SUPRA-B Inj. Drug Inter.

Thiamine mononitrate (BI ) BP 100mg, pyridoxine hydrochloride (B6) BP lOOmg and cyanocobalamin (BI2) BP I mg/3m! ampoule: i.m injection. 3ml amp x 5's pack: 125.00 MRP .:. TPC Tab. Acme

.:. PACIBION Tab. Pacific

Thiamine mononitrate (BI ) BP l OOmg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (BI2) BP 200mcg/tablet. 32's pack: 128.00 MRP

.:. POVITAL Tab. ACI

Thiamine mononitrate (B I) BP 100mg, pyridoxine hydrochloride (B6) BP l OOmg and cyanocobalamin (BI2) BP I mgl3ml ampoule: i.m injection. 3ml amp x 6's pack: 150.00 IP

Thiamine mononitrate (B1) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcgltablet. 30's pack: 150.00 MRP Thiamine mononitrate (BI) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 1 2) BP 200mcgltablet. 50's pack: 200.00 MRP .:. POVITAL Inj. ACI

Thiamine mononitrate (BI) BP 100mg, pyridoxine 'hydrochloride (B6) BP 1 00mg and cyanocobalamin (BI2) BP I mg/3m! ampoule: i.m injection. 3ml amp x 10's pack: 250.00 MRP .:. REBION Tah. Repheo

Thiamine mononitrate (BI) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (BI2) BP 200mcgltablet. 30's pack: 135.00 MRP .:. REB ION Inj. Repheo

Thiamine mononitrate (BI) BP l OOmg, pyridoxine hydrochloride (B6) BP l oomg and cyanocobalamin (B 1 2) BP I mgl3ml ampoule: i.m injection. 3ml amp x 10's pack: 250.00 MRP

.:. TPC Inj. Acme

.:. TRI-B Tab. White Horse

Thiamine mononitrate (BI ) BP l oomg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (BI2) BP 200mcgltablet. 75's pack: 300.00 MRP .:. TRIBION Tah. Globe

Thiamine mononitrate (BI) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 30's pack: 1 20.00 MRP .:. TRIBION Inj. Globe

Thiamine mononitrate (B I) BP l OOmg, pyridoxine hydrochloride (B6) BP l OOmg and cyanocobalamin (BI2) BP I mg/3ml ampoule: i.m injection. 3m! amp x lO's pack: 250.00 MRP .:. UNIBION Tab. Desh Pharma

.:. REJUBION Tab. Beacon

Thiamine mononitrate (B I) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B I2) BP 200mcg/tablet. 30's pack: 120.00 MRP

.:. RENEP Tab. Alco Pharma

Thiamine mononitrate (B I ) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 30's pack: 1 20.00 MRP

.:. RENOVIT Tab. Healtheare

Thiamine mononitrate (B I) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcgltablet. 30's pack: 200.00 IP

Thiamine mononitrate (BI) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 30's pack: 120.00 MRP Thiamine mononitrate (BI) BP 1 00mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcgltablet. 30's pack: 90.00 MRP Thiamine mononitrate (B I) BP l oomg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (BI2) BP 200mcgltablet (f.c). 30's pack: 120.00 MRP .:. SOLBION Tab. SK+F

Thiamine mononitrate (B I) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet. 50's pack: 200.00 MRP .:. SOLBION Inj. SK+F

Thiamine mononitrate (B I) BP 100mg, pyridoxine hydrochloride (B6) BP 100mg and cyanocobalamin (BI2) BP I mg/3ml ampoule: i.m injection. 3ml amp x lO's pack: 250.00 MRP .:. SUPRA-B Tab. Drug Inter.

Thiamine mononitrate (B I) BP 100mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcg/tablet.

.:. VIGOR-3 Tab. Hallmark

.:. VITABION Tab. Incepta

.:. VITABION Inj. Incepta

Thiamine mononitrate (BI ) BP 100mg, pyridoxine hydrochloride (B6) BP 100mg and cyanocobalamin (BI2) BP I mg/3ml ampoule: i.m injection. 3ml amp x 5's pack: 1 25.00 IP .:. VT-3 Tab. Decent

Thiamine mononitrate (BI) BP 1 00mg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B 12) BP 200mcgltablet. 32's pack: 128.00 MRP .:. 3BION Tab. RAK Pharma

Thiamine mononitrate (BI) BP loomg, pyridoxine hydrochloride (B6) BP 200mg and cyanocobalamin (B I2) BP 200mcgltablet. 50's pack: 200.00 MRP

Qnnym, (ViI. B,) � (Vit. B6)

VITAMIN 86 + 89 + 8 1 2 1 33 PYRIDOXINE (B6) + FOLIC ACID (B9) + CYANOCOBALAMIN (BI2): Tablet

This is a special combination product of folic acid, pyridoxine & cyanocobalamin, available as tablet. Each tablet contains folic acid BP 2.5mg, pyridoxine hydrochloride BP 25mg & cyanocobalamin BP I mg. Mode of action: Folic acid, pyridoxine & cyanocobalamin work closely together to control blood levels of the amino acid homocysieine. Elevated levels of this substance appear to be linked to heart disease & increased risk of stroke. The breakdown of dietary protein (meat, dairy products) generates methionine, which is then converted into homocysteine . . Homocysteine is then converted into cysteine where pyridoxine acts as a key co-factor. Homocysteine is converted back into methionine where folic acid & cyanocobalamin are the key co-factors. Ind: This combined preparation is indicated for the distinct nutritional requirements of individuals under a physician's treatment for hyperhomocysteinemia, homocystinuria, or nutrient malabsorption; with particular emphasis for individuals with or at risk for: cardiovascular disease, cerebrovascular disease, peripheral vascular disease, atherosclerotic vascular disease, neurological disorders, renal disease & vitamin B 12 deficiency. CII: Known hypersensitivity to any of the components in the product. SIE: Allergic sensitization has been reported following both oral & parenteral administration of folic acid. Paresthesia & somnolence have been reported with pyridoxine. Mild transient diarrhea, polycythemia vera, itching, transitory exanthema, and the feeling of swelling of the entire body has been associated with cyanocobalamin. Precaution: Folic acid when administered as a single agent in doses above 0.1 mg daily may obscure pernicious anemia in that hematologic remission can occur while neurological manifestation remain progressive. Dosage & admin: Usual adult dose is 1 or 2 tablets daily or as required. Drug inter: Pyridoxine supplement should not

be given to patients receiving levodopa, because the aClion of the latter drug is antagonized by pyridoxine. However, pyridoxi�e may be used concurrently in patients receiving a preparation containing both carbidopa & levodopa. Concurrent use of phenytoin & folic acid may result in decreased phenytoin effectiveness. .:. FOLBION Tab. Pacific

Pyridoxine hydrochloride (B 6) BP 25mg, folic acid (B 9) BP 2.5mg & cyanocobalamin (B 1 2) BP I mgltablet. 30's pack: 237.00 MRP .:. PFC Tab. Aristopharma

Pyridoxine hydrochloride (B 6) BP 25mg, folic

QIMP-15 (325)

acid (B9) BP 2.5mg & cyanocobalamin (B 1 2) BP

I mg/tablet. 30's pack: 1 80.00 MRP .:. VICARD Tab_ Popular Pyridoxine hydrochloride (B6) BP 25mg, folic

acid (B9) BP 2.5mg & cyanocobalamin (BI2) BP Img/tablet. 30's pack: 1 20.00 IP .:. VITA-HEART Tab_ Novo Healthcare Pyridoxine hydrochloride (B6) BP 25mg, folic acid (B9) BP 2.5mg & cyanocobalamin (BI2) BP Img/tablet. 30's pack: 90.00 MRP

VITAMIN B COMPLEX PREPNS ,2 1.33 VITAMIN B COMPLEX: Tablet/Capsule/ Syrup/Injection Ind: Vitamin-B complex deficiency states, such as during pregnancy, lactation, prolonged antibiotic therapy. convalescence, prophylaxis. Dose: Capsule & tablet prepns_ 1-2 caps/tabs daily_ Other prepns: See under individual drugs.

SK·F

Solvif-B Vitamin B-complex Sugar coaled tablet

.:. ADUVIT Cap_ Pacific Vitamin-B complex: capsule 200's pack: 104.00 MRP .:. ADUVIT Syp_ Pacific Vitamin-B complex: syrup 1 00ml bot: 20.00 MRP 200ml bot: 37.00 MRP .:. ALBAPLEX Syp. Aexim Vitamin-B complex: syrup 1 00ml bot: 20.60 MRP 200ml bot: 37.60 MRP .:. ALBATAB Tab. Aexim Vitamin-B complex: tablet 1 00's pack: 44.00 MRP .:. ALLBEEVIT Caplet Medimet Vitamin-B complex: caplet 45's pack: 1 9.80 MRP .:. ALLBEEVIT Cap_ Medimet Vitamin-B complex: capsule 1 00's pack: 57.00 MRP .:. ALLBEEVIT Tab_ Medimet Vitamin-B complex: tablet 100's pack: 44.00 MRP 200's pack: 88.00 MRP .:. ALLBEEVIT Syp. Medimet Vitamin-B complex: syrup 1 00ml bot: 20.60 MRP 200ml bot: 37.00 MRP .:. ALLBEEVIT Inj_ Medimet


Vitamin-B complex: injection� 2ml amp x IO's pack: 39.20 MRP .:. APEVIT-B Tab. A.P.C Pharma Vitamin-B complex: tablet l OO's pack: 40.00 MRP .:. APEVIT Syp. A.P.C Pharma Vitamin-B complex: syrup 1 00ml bot: 20.00 MRP 200ml bot: 37.60 MRP .:. APLEX Syp. Apollo Vitamin-B complex: syrup 1 00ml bot: 20.60 MRP 200ml bot: 37.60 MRP

Vitamin-B complex: capsule 200's pack: 1 1 4.00 MRP .:. BEFORTE Tab. Doctor's Vitamin-B complex: tablet 45's pack: 19.35 MRP .:. BEFORTE Syp. Doctor's Vitamin-B complex: syrup 1 00mi bot: 20.00 MRP 200ml bot: 37.00 MRP .:. BENVIT-B Tab. Benham Vitamin-B complex: tablet 45's pack: 1 8.90 MRP .:. BENVIT-B Susp. Benham Vitamin-B complex: syrup 100mi bot: 20.23 MRP 200ml bot: 37.42 MRP .:. BEVIT Tab_ Hudson Vitamin-B complex: tablet 100's pack: 43.00 MRP .:. BIOVIT Cap. Bio-Pharma Vitamin-B complex: capsule 200's pack: 1 14.00 MRP .:• .BIOVIT Syp. Bio-Pharma Vitamin-B complex: syrup 1 00ml bot: 20.80 MRP 200ml bot: 38.00 MRP

.:. ARISTOVIT-B Tab. Beximco Vitamin-B complex: tablet 45's pack: 20.25 MRP .:. ARISTOPLEX Syp. Beximco Vitamin-B complex: syrup 100mi bot: 20.83 MRP 200ml bot: 38.03 MRP .:. ASIVIT Tab. Asiatic Vitamin-B complex: tablet 60's pack: 36.00 MRP .:. BECONEX Cap. Renata Vitamin-B complex: capsule 30's pack: 1 7 . 1 0 MRP .:. BECONEX Syp. Renata Vitamin-B 177 mol/l), severe coagulation disturbances (except in Iife threatening emergncies), excess fluid overload (hyperhydration) and severe lack of fluid (dehydration), intra-cranial bleeding (cerebral haemorrhage), starch allergy, SIE:. The product may lead to anaphylactoid reactions in .isolated cases, In the event of intolerance reactions infusion is to be discontinued immediately and the standard emergency measures to be initiated, as below I , If skin reactions- give antihistamines, 2, If tachycardia, drop in blood pressure, vertigo, nausea, vomiting-, positioning of the patient & medical measure (Antihistamines + Corticosteroids e,g Prednisolone 120mg i,v), 3, If shock & bronchospasm- positioning of the patient & resuscitation + medical measure (i, Adrenaline 0,05-0,lmg i,v + ii, Corticosteroids e,g prednisolone 1 -2gm i,v + iii, infusion e,g Albumin 5%, 4, If respiratory and cardiac arrest- measure same as for shock & bronchospasm, Long-term daily administration of HAES-steril 6% or 10% in medium and high doses frequently causes an almost untreatable itching, This can still occur weeks after ending the therapy, persist over months and could be strained for the patient: Only in a rare number of cases were pains in the kidney area reported, In such cases, infusion is to be discontinued immediately, sufficient fluid to be infused and the serum creatinine values to be monitored closely, In higher doses, a rolongation of bleeding time can occur due to the dilution effect but clinically-relevant haemorrhage is not triggered, The fall in haematocrit and the dilution

I. Durgs used in bone & cartilage formation: These are further divided in to three grops: 1. Stimulation of bone formation: a. Hormone: Such as- Anabolic steroids. . b. Vitamin preparations: Such as

Vitamin-D (cholecalciferol) prepns, Fluoride. c. Other preparations: Such as

lpriflavone (also inhibits boneresorption)

DRUGS USED IN BONE

FORMATION & BONE DISORDERS2I.114

Drugs used i n bone formation & bone disorders can be classified under the following groups:

2. Inhibition of bone resorption: a. Hormone: Such as-

Calcitonin (Salcatonin a synthetic or recombinant salmon calcitonin) & Teriparatide (a recombinant fragment of parathyroid hormone); Oestrogens & HRT prepns.

b. Minerals: such as

Calcium salts; Phosphorus.

WATER & ELECTROLYTES REPLACEMENT

of the plasma proteins should be monitored, Precautions: Serum creatinine levels should be monitored at the beginning of therapy, Daily monitoring of the fluid balance and renal retention values is essential with limit-value creatinine values ( 1 .2-2,Omgldl and 106-177 molll, compensatory renal insufficiency), Despite normal serum creatinine values, pathological urine findings can indicate existing compensatory renal damage, In such cases daily serum creatinine values should be monitored daily, Where serum creatinine values and urine test results are nonnal, monitoring of renal retention values 1-2 times daily is essential in a therapy of several days duration, Sufficient supply of fluid (2-3 litres of fluid per day) must be ensured, Particular care must be taken with pulmonary oedema or chronic liver diseases. Pregnancy & lactation: There are no data available as yet with regard to use during pregnancy and breast-feeding, nor in children, To be administered only where indication is vital during early pregnancy, Dosage & admin: Please read package insert leaflet. Drug inter: No interactions with other drugs are

known to date,

N.B: For further information please contact the

manufacturer!s litepature.

.:. HAES-STERIL 6 % & Ul% Infusion Soln. Fresenius Kabi/Hyeimpex HAES-Steril 6% i,e 6% hydroxyethyl starch &

HAES-steril 10% i,e 10% hydroxyethyl starch in isotonic sodium chloride solution: solution for i. v infusion Composition: See above under the text. 6% x 500ml'bot: 607,77 MRP 10% x 500ml bot: 744,00 MRP .:. INFUKOLL HES 6% & 10% Infusion Soln. Serumwerk BernbergAGITajarat Infukoll HES 6% i,e 6% hydroxyethyl starch &

Infukoll HES· 10% i,e 10% hydroxyethyl starch in isotonic sodium chloride solution: solution for Lv infusion Composition: See above under the text. 6% x 500ml bot: 10% x 500ml bot:

c. Bisphosphonates: such as

Alendronate sodium, Disodium etidronate, Disodium pamidronate, lbandronic acid, Risedronate sodium, Sodium clodro;lUte, Tiludronic acid, Zoledronic acid. d. Other preparations: such as

Ipriflavone, Reloxifene, Strontium ranelate. 3. Stimulation of cartilage formation: such as- Glucosamine & Chondroitin. II. Drugs used in inflammatory diseases of bones & joints: 1. Antirheumatic & anti-inflammatory drugs- discussed in the respective chapter, 2. Drugs for Osteoarthritis (degenerative joint disease or osteoarthrosis): i. For pain relief: Paracetamol &

DRUGS USED IN BONE DISORDERS

NSAIDs- discussed in the respective

111_

chapter. ii_ Supplement of natural hyaluronic acid in the synovial fluid of the knee joint, such as- Sodium hyaluronate. Drugs used in bone infections (Osteomyelitis)- discussed under antimicrobial drugs.

DRUGS USED IN BONE & CARTILAGE FORMATION 1. Stimulation of bone formation Hormone in bone formation by stimulation

ANABOLIC STEROIDS Hormone in bone formation by stimulation, such as anabolic steroids- discussed in the chapter of endocrine hormones, under anabolic steroids.

Vitamin in bone formation

VITAMIN-D Vitamin in bone formation, such as vitamin D discussed in the chapter of 'vitamin, minerals & nutritionI under vitamins.

2. Inhibition of bone resorption Hormone in bone formation by Inhibition of bone resorption

CALCITONIN2 l.' ' 4 Calcitonin is a polypeptide hormone secreted by

the parafollicular cells of the thyroid gland in mammals. It is involved with parathyroid hormone in the regulation of bone turnover and hence in the maintenance of calcium balance and homoeostasis. It is normaly present in blood, and its concentration increases when the calcium concentration is excessive as after eating or when calcium salts are administered. It inhibits bone resorption leading to hypocalcemia- an effect more apparent in children and patients with Paget's disease than in normal adults. Synthetic calcitonin is used clinically to treat Paget's disease and hypercalcemia, and it has also been tried in postmenopausal osteoporosis treatment.

SALMON CALCITONIN" 4 SALMON CALCITONIN: InjectionlNasal spray Salmon calcitonin, a synthetic calcitonin hormone; available in injection & nasal spray form.

QIMP-15 (356) Mode of action: Calcitonin has a hypocalcemic action by direct inhibition of bone resorption by osteoclastic cells. Among the available types of calcitonin, including synthetic human, synthetic salmon calcitonin is the most potent. Salmon calcitonin is used in the treatment of selected patients with diseases characterized by increased bone resorption, such as osteoporosis, Paget's disease of bone (osteitis deformans) and Sudeck's disease of bone. Ind: I . Osteoporosis of different types- i. Post menopausal osteoporosis, ii. Senile osteoporosis, iii. Secondary osteoporosis. 2. Paget's disease of bone. 3. Sudecks's disease of bone. 4. Hypercalcemia, due to osteolysis in course of breast, lung and renal cancers and other malignancies. 5. Hyperparathyroidism & vitamin D intoxication and 6. also in the treatment of bone pain due to metastatic cancers. CII: Salmon calcitonin must not be administered in cases of suspected pregnancy or during lactation. Clinical hypersensitivity to salmon calcitonin. AIR: By injection: In some cases nausea, vomiting, diarrhea, face redness and heat sensation have been reported. These reactions usually disappear spontaneously as treatment progresses. There can be occasionally inflammatory reactions at the injection site. Troublesome side effects may be reduced by bed time administration. Anti-emetics may be used if necessary during treatment. By nasal spray: The incidence of systemic side effects is much lower than by injection. Local side effects, such as rhinorrhea, mucosal dryness, nasal obstructions, sneezing & hyposmia may appear, but these effects usually do not require withdrawal of the treatment as they generally regress spontaneously. Precautions & warnings: In very rare cases, salmon calcitonin, being a polypeptide, can give rise to hypersensitive reactions either local or general; in the cases of such reactions, the treatment must be stopped and, if necessary, substitute by a suitable treatment. Salmon calcitonin must not be administered in cases of suspected pregnancy or during lactation. Dosage & Admin:

Osteoporosis: Injection- 50-100 IV/day, soc or tm together with calcium and vitamin D supplementation_ In some cases, the injection can be administered on alternate days_ If necessary, the dosage can be increased to 200 IV/day_ Intranasal spray: 100-200 IV/day depending on severity of the disease, together with calcium & vitamin D supplementation_ In case of giving 100 IV/day, one spray a day, alter nating nostrils daily_ In case of giving 200 IV/day, two sprays a day, one in the morning and one in the evening, alternating nostrils_ Paget's disease: Injection: 50-100 IV/day, soc or tm_ In some cases, the injection can be administered on alternate days_ If necessary, the dosage can be increased to 200· IV/day_ Intranasal spray: 200 IV/day; two sprays a day, one in the morning and one in the evening, alternating nostrils_ Treatment should be at least 3 months irrespective of the route of administration_

Dosage may be adjusted to the individual requirements.

Hypercalcemia (following cancers and hyperparathyroidism): Hypercalcemic crisis: Injection- 5-10 IV/kglday over a period of at least 6 hours in tv drip (most preferred & effective method) or by slow i_v injection in 2-4 divided doses,

Chronic hypercalcemia: Injection: 5-10 IV/kglday, soc' or tm in one or two divided doses_ The treatment should be adapted to clinical and biochemical reaction of the patient_ Intranasal spray: 200-400 IV/day depending on severity of the condition, alternating nostrils_

Sudecks's disease: Injection: 50-100 IV/day, soc or tm_ In some cases, the injection can be administered on alternate days_ If necessary, the dosage can be increased to 200 IV/day_ Intranasal spray: 100-200 IV/day depending on severity of the disease_ In case of giving 100 IV/day, one spray a day, alternating nostrils daily_ In case of giving 200 IV/day, two sprays a day, one in the morning and one in the evening, alterna.ting nostrils_

Bone pain due to metastatic cancers: Injection50-100 IV/day, soc or tm_ Intranasal spray: 100-200 IV/day depending on severity of the disease_ In case of giving 100 IV/day, one spray a day, alternating nostrils daily_ In case of giving 200 IV/day, two sprays a day, one in the morning and one in the evening, alternating nostrils_ Irrespective of the route of administration, dosage should be adjusted to individual requirements_ Overdose: High doses of salmon calcitonin can provoke a notable hypocalcemia, which should be corrected by administrating calcium. However, no serious consequences due to overdose have yet been reported. An overdose of 1000 IV by s.c injection, may produce nausea and vomiting as the only adverse effect. .:. MIACALCIC Inj_ Novartis Salmon calcitonin 100 IV/ I ml ampoule: injection. 1ml amp x 5's pack: 2015 .00 MRP .:. MIACALCIC Nasal Spray Novartis Salmon calcitonin 200 IV per actuation or delivery; 2200 IV/ml; 2ml solution for a minimum of 22 deliveries of 200 IV. 22 inhalations (2ml) unit: 1 990.00 MRP .:. TONOCALCIN Inj_ Alfa Wassermann ltalylHyeimpex Salmon calcitonin 100 IVIl ml ampoule: injection. h nl amp x 5's pack: 1080.00 MRP

Minerals in bone formation CALCIUM SALTS Minerals in bone formation by inhibition of bone resorption, such as calcium salts-discussed in the chapter of 'vitamin, minerals & nutrition' under minerals.

QIMP-15 (357)

Bisphosphonate preparations ALENDRONATE42 ALENDRONATE: Tablet Alendronate sodium is a non-honnonal compound belonging to the bisphosphonate group, used in bone fonnation specially in osteoporosis in old ages.

Mode of action: At the cellular level alendronate shows preferential localization to sites of bone resorption, specially under osteoclasts. It does not interfere with osteoclast recruitment or attachment, but it inhibits osteoclast activity. It reduces bone turnover i.e the number of sites at which bone is remolded. In addition, bone fonnation exceeds bone resorption at these molding sites, leading to progressive gains in bone mass.

Ind: I. Treatment and prevention of osteoporosis

in post-menopausal women. 2. For the prevention of osteoporosis. 3. Treatment of Paget's disease of bone.

CII: Abnonnalities of the oesophagus which can delay oesophageal emptying, such as stricture or achalasia. Inability to stand or sit upright for at least 30 minutes. Hypersensitivity to any component of this product. Hypocalcaemia.

S/E: Usually mild and not require discontinua tion of therapy. Side-effects include- oesophageal

reactions, abdominal pain & distension, diarrhoea or constipation, flatulence, musculoskeletal pain,

headache, rash, erythema and transient decrease

the alendronate tablet & do not lie down until after eating breakfast. Patients should not

chew or suck on the tablet & don't take the

tablet at bed time_

Children- not recommended_

Drug inter: Calcium supplement, antacids and some oral medications will interferewith absorption of alendronate if taken at the same time. Intravenous ranitidine makes the bioavailability of oral alendronate double. Incidence of upper gastrointestinal adverse effects associated with NSAID and aspirin appears to be greater with concomitant administration of alendronate.

:. ALENDON-70 Tab_ Beximco

•

Alendronate sodium, equivaknt to alendronic acid 70mg/tablet. 30's pack: 7S0.00 MRP

.:. OSTEL 10 Tab_ Square Alendronate sodium 13.0Smg, equivalent to alendronic acid 10mg/tablet. 30's pack: ISO.OO MRP

.:. OSTEL 70 Tab_ Square Alendronate sodium, equivalent to alendronic acid 70mgltablet. 12's pack: 300.00 MRP

.:. OSTOMAX 10 Tab_ SK+F Alendronate sodium 13.05mg, equivalent to alendronic acid l Omgltablet. 40's pack: 200.00 MRP

.:. OSTOMAX 70 Tab_ SK+F Alendronate sodium, equivalent to alendronic acid 70mgltablet. 8's pack: 200.00 MRP

in serum calcium & phosphate.

Precautions: Hypocalcaemia and other disturbances of mineral metabolism should be

corrected before initiation of therapy. Alendronate can cause local irritation of the

.:. BONVIVA Tab_ Roche One ISOmg film-coated tablet contains 168.75mg

potential for worsening of the underlying disease.

of ibandronic acid monosodium salt, monohydrate equivalent to lS0ing ibandronic acid.

given to the patients with active upper

Mode of action: Ibandronic acid is a highly

gastrointestinal problems, such as dysphagia,

potent bisphosphonate belonging to the nitrogen

oesophageal disease, gastritis, duodenitis or

containing group of bisphosphonates, which acts

ulcers. Patients should stop taking medicine and

on the bone tissue & specifically inhibits

consult their physician if they develop

osteoclast activity without directly affecting bone

oesophageal diseases, such as difficulty or pain

fonnation. It does not interfere with osteoclast

upon swallowing, retrosternal pain, new or

recruitment. The selective action of ibandronic

worsening heart burn.

acid on bone tissue is based on the high affinity

No dosage adjustment is necessary for the elderly

of this compound for hydroxyapatite, which

or for patients with mild-to-moderate renal

represents the mineral matrix of the bone.

insufficiency (creatinine clearance 35 to 60

Ibandronic acid reduces bone resorption, with no

mllmin). Alendronate is not recommended for

direct effect on bone formation.

patients with more severe renal insufficiency

In postmenopausal women, it reduces the elevated

(creatinine clearance < 35ml).

rate of bone turnover towards premenopausal

Pregnancy & Lactation: Alendronate has not

lavels leading to a progressive net gain in bone

been studied in pregnant and breast feeding

mass.

women, and hence should not be given to them.

Dosage and Admin:

Post-menopausal osteoporosis: 10mg once daily_ Paget's disease of bone: 40mg once daily for 6

Ind: Ibandronic acid is indicated for the treatment of postmenopausal osteoporosis, to reduce the risk of fractures.

CII: Bonviva is contraindicated in patients with

months_

known hypersensitivity to ibandronic acid or to

tablet must be taken in an empty stomach

AIR: In a one-year study in postmenopausal

before the breakfast or flrst food or drink or

(ibandronic acid) ISOmg once monthly, the

sit upright for at least 30 minutes after taking

were mild to moderate in intensity, and most

To permit adequate absorption, alendronate with a full glass of water, at least 30 minutes medication of the day_ Patients should stand or

cases did not lead to cessation of therapy. The

common adverse reactions (> 1110) were

dyspepsia, nausea, abdominal pain & diarrhoea; .

. headache; myalgia; skin rash & influenza like illness.

Precautions & warnings: Hypocalcemia & other disturbances of bone & mineral metabolism· should be effectively treated before starting

bonviva therapy. Adequate intake of calcium &

vitamin D is important in all- paitents. Bisphosphonates have been associated with

dysphagia, esophagitis, & esophageal or gastric

ulcer. Therefore, patients should pay particular attention & be able to comply with the dosing instructions. Physicians should be alert to sings or symptoms signalling a possible esophageal reaction during therapy, and patients should be instructed to

discontinue therapy & seek medical attention if they develop symptoms of esophageal irritation, such as new or worsening dysphagia, pain on swallowing, retrosternal pain, or heart bum.

Since NSAIDs & bisphosphonates are both

associated with gastrointestinal irritation, caution should be taken during concomitant medication with bonviva.

Pregnancy & lactation: Bonviva should not be used during pregnancy & lactation.

Dosage & admin: The recommended dose of

ibandronic acid for treatment

is IS0mg (one

film-coated tablet) once a month_ The tablet

should preferably be IlIken on the same date each month_

Method of administration: Ibandronic acid

should be taken 60 minutes before the first food or drink (other than water) of the day or any

IBANDRONIC ACIDsO

upper gastrointestinal mucosa, and there is a Caution should be adoptet when alendronate is

DRUGS USED IN.BONE DISORDERS

any of the excipients. women with osteoporosis treated with bonviva

majority of adverse drug reactions observed,

other oral medicine or supplementation

(including calcium). Tablet should be swallowed

whole with a full glass of plain water (180-

240ml) while the patient is sitting or standing in an upright position. Patients must not.lie down for 60 munites after taking bonviva (ibandronic acid)_ Plain water is the pnly drink that shonld

be taken with bonviva_ (Some mineral waters

may have a higher concentration of calcium &

therefore should not be used)_ Patients should not chew or suck the tablet because of a potential for oropharyngeal ulceration_

Pateints should receive supplemental calcium or vitamin D if dietary intake is inadequate_

Missed dose:

In case a once- monthly dose is

missed, patients should be instructed to take

bonviva (ibandronic acid) IS0mg tablet in the

next morning of remembering the dose, unless the time to the next scheduled dose is within 7

days_ Patients should then return to taking their dose once a month on their originally scheduled

date_

If the next scheduled dose is within 7 days,

pateints should wait until their next dose & then continue taking one tablet once a month as

originally scheduled. Patients should not take two tablets within the same week.

Special dosage instructions: Patients with

hepatic impairment- no dose adjustment is

necessary_ Patients with renal impairment- no dose adjustment is necessary with mild or

moderate renal impairment where creatinine

clearance is equal to or greater than 30mllmin; below 30mllmin creatinine clearance, the

QIMP-IS (358)

D!l.UGS USED IN BONE DISORDERS '.

decision to administer bonviva should be based on an individual risk-benefit assessment. Elderly- no dose adjustment is necessary. Children: Safety & efficacy have not been established in patients less than 18 years old. Drug inter : It is likely that calcium supplements, antacids

& $.Orne oral medications containing

multivalent cations (such as aluminium, magnesium ion) are likely to interfere with

and mineral metabolism (e.g parathyroid

of the excipients or to any bisphosphonate;

treated at the time of risedronate therapy. In

hypocalcemia;

patients who have a lack of vitamin D or problem

AIR: Adverse reactions are usually mild and

with the parathyroid glands, risedronate should

transient and similar to those reported for other

be used with special caution.

intravenously administered bisphosphonates.

Pregnancy & lactation: Risedronate must not be . used during pregnancy or breastfeeding.

antiresorptive agent. At the cellular level,

Dosage & admin: Tlie recommended daily dose is Smg (1 tablet) orally. The absorption of risedronate is affected by foods and drinks, so, this should not be taken with food or drinks other than water. Take the dose (1 tablet) once daily, either at least 30 minutes before the first food or drink (other than water of the day). Or at least 2 hours from any food or drink at any other time of the day, and at least 30 minutes before going to bed. Supplemental calcium and vitamin D should be considered if the dietary intake is inadequate. 10 all cases including duration of treatment physician's prescription and advice must be strictly followed. Children: Safety and efficacy of risedronate have not been established in children and adolescents. Overdosage: In case of overdosage or accidental

risedronate inhibits osteoclasts. The osteoclasts

intoxication one should drink a full glass of milk

adhere normally to the bone surface, but show

and immediately contact physician or hospital.

absorption of ibandronic acid. Therefore, patients must wait 60 minutes after taking bonviva (ibandronic acid before taking other oral . medications.

Note: For further information,

please consult

manufacturer's literature. 150mg tab. x l 's pack: 37 1 2.50 MRP

RISEDRONATE35 RISEDRONATE: Tablet Risedronate sodium is a non-hormonal compound belonging to the bisphosphonate group, used in bone formation specially in osteoporosis in postmenopausal women and in old ages.

Mode of action: Risedronate has an affinity for hydroxyapetite crystats in bone and acts as an

CII: Hypersensitivity to zoledronic acid, to any

dysfunction, hypo-vitaminosis D) should be

evidence of reduced active resorption (e.g lack

Decreases in serum calcium following substantial

of ruffled border). Histomorphometry in rats, .

overdose may be expected. Signs and symptoms

dogs and mini pigs showed that risedronate

of hypocalcaemia may also occur in some of

treatment reduces bone turnover (activation

those patients. Milk or antacids containing

frequency, i.e the rate at which bone remodeling

magnesium, calcium or aluminium should be

sites are activated) and bone resorption at

given to bind risedronate sodium and reduce

remodeling sites.

absorption of the drug. Incase of substantial

Common are- influenza, hypocalcemia, headache, · lethargy, dyspnoea, diarrhoea, nausea, dyspepsia, bone pain, arthralgia, myalgia, flu-like symptoms, pyrexia, rigors, fatigue, pain, asthenia. The following side effects have been reported with bisphosphonates: renal dysfunction, iritis, uveitis, episcleritis, conjunctivitis and osteonecrosis of the jaw.

Precautions: Zoledronic acid is not recommended in patients with severe renal impairment (creatinine clearance < 30mllmin) or in children and adolescents. Patients must be appropriately hydrated prior to administration of zoledronic acid. Pre-existing hypocalcemia and 'other disturbances of mineral metabolism must be treated by adequate intake of calcium and vitamin D before initiating therapy with zoledronic acid. It is strongly advised that patients with Paget's disease receive supplemental calcium and vitamin D. This should be ensured during the initial 10 days following zoledronic acid administration.

Pregnancy & lactation: Zoledronic acid is contraindicated in pregnancy & lactation. Dosage & admin: One i.v infusion of Smg zoledronic acid (anhydrous) in 100ml aqueous solution. The infusion time should be at least 15 minutes. No dose adjustment in patients with creatinine clearance 40mVminute or hepatic impairment. Drug inter: Caution is recommended when zoledronic acid is used concomitantly with drugs

Ind: Risedronate is intended for the use in the

overdose, gastric lavage may be considered to

following conditions. I. Treatment of established

remove unabsorbed drug.

postmenopausal osteoporosis; prevention of

Drug inter: If considered appropriate,

osteoporosis in postmenopausal women with

risedronate may be used concomitantly with

increased risk of osteoporosis. 2. Prevention and

oestrogen supplementation. Concomitant

treatment of osteoporosis associated with

ingestion of products containing calcium,

glucocorticoid therapy (daily dosage equivalent

magnesium, iron and aluminium may interfere

to 7.5mg or greater of prednisone) for chronic

with the absorption of risedronate. These

.:. ZOMETA Inj. Novartis

inflammatory disease.

products should be taken at different times of the

Zoledronic acid 4mg/vial with ampoule of Sml

that can significantly impact renal function, such as aminoglycosides and diuretics that can cause dehydration.

Note: For further information consult full prescribing information. 5mg in 100ml bot x I's pack: 27592.50 MRP

CII: Known hypersensitivity to risedronate

day apart from risedronate dose. Risedronate is

water for reconstitution: injection.

sodium or to any of its ingredients.

not systemically metabolized, does not induce

Ind: Prevention of skeletal-related events

Hypocalcaemia (a low blood calcium level).

P450 enzymes and has low protein binding.

(pathological fractures, spinal compression,

Pregnancy and lactation. Severe renal impairment (creatinine clearance

AIR: Neutropenia, thrombocytopenia, anaentia, peripheral neuropathy, infectious episodes, asthenia, mucositis, injection site reactions, gastrointestinal upsets, hypotension, arthralgia

90mVntin) prior to start of therapy with platosin.

and myalgia.

Before adntinistration, adequate hydration and

Precautions & warnings: Administer in units

diuresis should be ascertained, and appropriate a nti-emetic medication should be given.

Audiometric monitoring is recommended prior to

and during therapy with platosin.

The toxic effects commonly necessitate dose reduction and/or drug withdrawal. It is pre ferable that treatment with this drug be super vised by specialists familiar with its use.

Dosage & admin: Platosin, powder for injection 10mg and 50mg should be reconstituted with lOml or 50ml respectively, of sterile normal saline. To decrease the nephrotoxicity pretreatment hydration with aUeast 1 litre of 5 % dextrose! 0.9% saline (1:1) is recommended. When urine flow is less than looml per hour, loo-2oomI I5% mannitol may be administered. It is recommen ded to administer Platosin in 2 litres 5% dextrose! 0.9% saline (1:1)

specializing in cytotoxic chemotherapy under the supervision of an oncologist. Reduce dosage in

patients with febrile neutropenia, neutrophil count <SOO x 1 091L for more than one week, severe or cumulative cutaneous reactions or

severe peripheral neuropathy. Severe

hypersensitivity reactions require intmediate discontinuation of the drug and appropriate

therapy should then start. Severe cutaneous skin reactions, such as eruptior)s require interruption

or discontinuation of treatment. Patients with

severe fluid retention such as pleural effusion, pericardial effusion or ascites should be

monitored closely. In patients who have both elevations of transantinase values (ALT and/or AST) greater than I .S times the upper lintit of normal (ULN)

& increases in alkaline

phosphatase greater than 2.S times the ULN, the reco-mmended dose of docetaxel is 7Smglm2.

QIMP·15 (369)

Premedication: Premedication with a

marrow examination, if indicated, as well as

corticosteroid (dexamethasone) by mouth for five

kidney function and liver function should be

days, starting on the day before each course of

determined prior to, and repeatedly during

docetaxel, is recommended for reducing fluid

treatment. The determination of the hemoglobin

retention and hypersensitivity reactions.

level, total leukocyte counts, and platelet counts

Dosage & admin: Adult· 100mglm2 adminis· tered as a one·hour i.v. infusion every three weeks. Elderly, no special instruction. Child· safety and efficacy not established. Hepatic impairment: reduce dosage, discontinue in severe cases. Adminisration: Reconstitute the concentrate preparation with accompanying solvent vial and dilute with infusion solution (0.9% sodium chloride or 5% dextrose for i.v injection) before use. The concentration of Docetaxel in infusion solution should be between 0.3· 0.9mglml. Apply usual cytotoxic caution when preparing or handling the drug. Drug Inter: modification of cytochrome P450· 3A by concomitant medication may alter the metabolism of docetaxel. Caution should be exercised when treating patients with such drugs. 20mg vial with solvent: 20902.50 MRP

should be peiformed at least once a week throughout the course of hydroxyurea therapy. If the white blood cell count decreases to less than 2500/mm3, or the platelet count to less than 100,000/mm3, therapy should be interrupted until the values rise significantly toward normal levels. Severe anemia, if it occurs, should be managed without interrupting hydroxyurea therapy. Hydroxyurea should be used with caution in patients with marked renal dysfuncition. Patients , who develop signs and symptoms of pancreatitis or hepatotoxicity should permanently discontinue

use of hydroxyurea with other drugs in humans. Concurrent use of hydroxyurea and other

Pregnancy & lactation: Drugs which affect

myelosuppressive agents or radiation therapy

DNA synthesis, such as hydroxyurea, may be potential mutagenic agents. Hydroxyurea can cause fetal harm when administered to a pregnant woman. But, there are no adequate and well· controlled studies in pregnant women. If this

HYDROXYCARBAMIDE (HYDROXYUREA)"

becomes pregnant while taking this drug, the

.:. HYDREA Cap. Bristol·Myers Squibbl Kapricorn

Hydroxyurea is excreted in human milk. Because

patient should be apprised of the potential harm

antineoplastic agent. It's mode of action is still hypothetical, that hydroxyurea causes an immediate inhibition of DNA synthesis by acting as a ribonucleotide reductase inhibitor, without interfering with synthesis of ribonucleic acid or of protein. For more information, consult manufacturer's literature.

Ind: Significant tumor response to hydroxyurea has been demonstrated in melanoma, resistant chronic myelocytic leukemia,

& metastatic, or

inoperable carcinoma of the ovary. Hydroxyurea used concomitantly with irradiation therapy is intended for use in the local control of primary squamous cell (epidermoid) carcinomas of the head

& neck, excluding the lip.

CII: Hydroxyurea is contraindicated in patients with marked bone marrow depression i.e leukopenia « 2500/mm3 WEC) or thrombocytopenia ( 1 .5 times the upper limit of the normal

cramps (33%), and rash (25%). Superficial

range, severe bone marrow failure, who

Oxaliplatin 50mg! I Oml concentrate solution in vial: for i. v infusion.

Oxaliplatin is a cytotoxic antineoplastic drug belonging to platinum compounds.

Ind: Oxaliplatin in combination with 5-

fluorouracil (5-FU) and folinic acid (FA) is

indicated for: I . Adjuvant treatment of stage III (Duke's C) colon cancer after complete resection

of primary tumour; 2. Treatment of metastatic colorectal cancer.

CII: Oxaliplatin is contraindicated in patients-

L with known history of hypersensitivity to oxaliplatin, iL breast feeding, iii. who have

myelosuppression prior to starting first course, as

evidenced by baseline neutrophils 2.

have a pedpheral sensitive neuropathy with

lower limb oedema ( 1 7%). Neutropenia,

Alkeran

SIE; Cautions & Warnings: See above under & also consult manufacturer's literature.

who have a severely impaired renal function

were described primarily as periorbital (30%), or

functional impairment prior to first course, v.

QIMP·15 (371)

(creatinine clearance less than 30mllmin).

free and overall survival in the total popUlation of

SIE; Precautions & warnings: Please see the

patients with receptor-positive and receptor


Dosage & admin: For adults only. The recommended dose for oxaliplatin in adjuvant setting is 85mglm2 intravenoulsy, repeated every two weeks tor 12 eycles (6 months). The recommended dose for oxaliplatin in treatinent of metastatic colorectal cancer is 85mglm2 intravenously, repeated every 2 weeks. Dosage given should be adjusted according to tolerability. Oxaliplatin should always be administered before 5-fluorouracil. Oxaliplatin is administered as a 2· to 6·hour i.v infusion in 250 to 500ml of 5 % glucose solution to give a concentration between 0.2mglml and 0.7mglml; 0.7mglml is the highest concentration in clinical practice for an oxaliplatin dose of 85mglm2. Oxaliplatin was mainly used in combination with continuous infusion 5-fluorouracil based regimens. For the two· weekly treatment schedule 5-fluorouracil regimens combining bolus and continuous infusion were used. After dilution oxaliplatin solution must be infused via a central venous line or peripheral , vein over 2 to 6 hours. In the event of extravasation, administration must be discontinued immediately. Renal & hepatic impairment: Oxaliplatin has not been studied in patients with severe renal and hepatic impairment. In patients with moderate renal impairment, treatment may he initiated at the nonnally recommended dose. There is no need for dose adjustment in patients with mild renal dysfunction. No specific dose adjustment for patients with abnormal liver function tests was performed during clinical development. Elderly patients: No specific dose adaptation is required for elderly patients. Oxaliplatin should only be used in specialised departments of oncology and should be administered under the supervision of an experienced oncologist. Drug inter: Please see the manufacturer's literature.

Note: For full information,

please consult


50mg ( IOml) vial x I 's pack: 20500.00 TP

PACLITAXEL5 1 PACLITAXEL: Injection

Paclitaxel is a natural product with anti-tumor activity. It is obtained by semi-synthetic process

from Taxus baccata.

Ind: Paclitaxel is indicated as first-line and

subsequent therapy for the treatment of advanced carcinoma of the ovary. As the first-line therapy, paclitaxel

is indicated in combination with

cisplatin.

Paclitaxel is .indicated for the adjuvant treatment

of node-positive breast cancer administered sequentially to standard doxorubicin-containing combination chemotherapy. In the clinical trial, there was an overall favorable effect on disease-

negative tumors, but the benefit has been specifically demonstrated by available data (median follow-up 30 months) only in the patients with estrogen and progesterone receptor negative tumors. Paclitaxel is indicated for the treatment of breast cancer after failure of combination chemotherapy for metastatic disease or relapse within 6. months of adjuvant chemotherapy. Prior therapy should have included an anthracycline unless clinically contraindicated. Paclitaxe,l in combination with cisplatin, is indicated for the first-line treatment of non-small cell lung cancer in patients who are not candidates for potentially curative surgery and/or radiation therapy. Paclitaxel is indicated for the second-line treatment of AIDS-related Kaposi's sarcoma.

CII: Paclitaxel is contraindicated in patients who have a history of hypersensitivity reactions to

paclitaxel or other drugs formulated in Cremophor EL (polyoxyethylated castor oil). Paclitaxel should not be used in patients with solid tumors who have baseline neutrophil counts of < 1500 cells/mm3 or in patients with AIDS related Kaposi's sarcoma with baseline neutrophil counts of < 1 000 cells/mm3.

SIE; Warnings; Preacution: Please consult manufacturer's literature.

Contact of the undiluted concentrate with plasticized PVC equipments or devices used to prepare solutions for infusion is not recommended. In order to minimize patient expOsure to the plasticized DEHP [di-(2ethylhexyl) phthalatel, which may be leached from PVC infusion bags or sets; diluted paclitaxel solutions should be stored in' bottles (glass, polypropylene) or plastic bags (polypropylene, polyolefin) and administered through polyethylene-lined administration sets.

Dosage & admin: All patients should be premedicated prior to paclitaxel administration in order to prevent severe hypersensitivity reactions. Such premedication may consist of dexamethasone 20mg administered orally approximately 12 and 6 hours before paclitaxel, diphenhydramine (or its equivalent) 50mg I.V 30 to 60 minutes prior to paclitaxel, and cimetidine (300mg) or ranitidine (50mg) I.V 30 to 60 minutes before paclitaxel. Treatment regimen: For patients with carcinoma of the ovary, the following regimens are recommended. 1. For previously untreated patients with carcinoma of the ovary, one of the following recommended regimens may be given every 3 weeks. In selecting the appropriate regimen, differences in toxicities should be considered. a. Paclilaxel administered i.v over 3 hours at a dose of 175mglm2 followed by cisplatin at a dose of 75mglm2. Or, b. Paclitaxel administered i. v over 24 hours at a dose of 135mglm2 followed by cisplatin at a dose of 7Smglm2.

CARCINO·CHEMOTHERAPEUTIC DRUGS

2.

10 patients previously treated with

chemotherapy for carcinoma of the overy, paclitaxel has been used at several doses and schedules; however, the optimal regimen is not yet clear. The recommended regimen is paclitaxel 135mglm2 or 175mglm2 asministered i.v over 3 hours every 3 weeks. For patients with carcinoma of the breast, the following regimens are recommended. 1. For the adjuvant treatment of node-positive breast cancer, the recommended regimen is paclitaxel, at a dose of 175mglm2 i.v over 3 hours every 3 weeks for 4 courses administered sequentially to doxorubicin containing comiJination chemotherapy. 2. After failure of initial chemotherapy for metastatic disease or relapse within 6 months of adjuvant chemotherapy, paclitaxel at a dose of 17Smglm2 administered intravenously over 3 hours every 3 weeks has been shown to be effective. Patients with non·small cell lung carcinoma: The recommended regimen is 13Smglm2 administered intravenously over 24 hours followed by cisplatin 7Smglm2 every 3 weeks. Patients with AIDS-related Kaposi's sarcoma: Paclitaxel adminstered at a dose of 13Smglm2 given intravenously over 3 hours every 3 weeks or at a dose of 100mglm2 given intravenously over 3 hours every 2 weeks is recommended (dose intensity 45· SOmglm2/week). In the two clinical trials evaluating these schedules, the former schedule (135mglm2 every 3 weeks) was more toxic than the latter. In addition, all patients with low performance status were treated with the latter schedule (100mglm2 every 2 weeks). Drug inter: Please consult manufacturer's literature.

Note: For further information, consult manufacturer's literature.

.:. PACLITAXEL Inj. Gosun Pharmal Medinam Paclitaxel 30mg/5ml vial: injection. 5ml (30mg) vial: 3000.00 MRP

.:. TAXOL loj, Bristol-Myers Squibb/ Kapricorn Paclitaxel 30mg/5ml vial: injection.

5ml (30mg) vial: 4320.32 MRP

RETINOIC ACID50 .:. VESANOID Cap. Roche

All trans retinoic acid 1 0mg/capsule (soft gelatin).

Mode of action: Tretinoin is not a cytolytic

agent but instead induces cyto-differentiation and decreased proliferation of APL cells in culture and in vivo.

Ind: Retinoic acid is indicated for the induction

of remission in patients with acute promyelocytic leukemia (APL), French-American-British (PAB) classification M3 (including the M3 variant), or who are refractory to, or who ha"e relapsed from, anthracycline chemotherapy, or for whom a?thra�ycline-based chemotherapy is

CARCINO-CHEMOTHERAPEUTIC DRUGS

QIMP-lS (372)

contraindicated. All patients should receive

Precautio,," & warnings: Serious adverse

especially blood counts; infection, concurrent

completion of induction therapy with retinoic acid.

dyspnea, hypotension, wheezing, bronchospasm,

relaxants; Pregnancy; under sun exposure.

respiratory distress have been reported

daily.

consolidation andlor maintenance therapy after

reactions to trastuzumab infusion induding

CII: Retinoic acid is contraindicated in patients

tachycardia, reduced oxygen saturation and

SIE: Virtually all patients experience some drug

infrequently. The trastuzumab infusion should be

with a known hyperse�sitiVity to retinoids. related toxicity, specially headache, fever,

weakness, and fatigue. These adverse effects are

discontinued and the patient monitored until

resolution of any' observed symptoms. Serious

seldom permanent or irreversible nor do they

reactios have been treated successfully with

the adverse events are common in patients with

and corticosteroids.

usually require interruption of therapy. Some of

APL, induding hemorrhage, infections,

gastrointestinal hemorrhage, disseminated

supportive therapy such as oxygen, beta-agonists

Pregnancy & lactation: Trastuzumab should be avoided during pregnancy and lactation unless

intravascular coagulation, pneumonia, septicemia,

tbe potential benefit for the mother outweighs the

Precautions & warnings: Retinoic acid

Dosage & admin: HER2 testing is mandatory prior to initiation of trastuzumab tberapy_ Loading dose: Tbe recommended initial loading dose is 4mg/kg body weigbt as a 90minute intravenous infusion_ Subsequent doses: Tbe recommended weekly dose of trastuzumab is 2mg/kg body weigbt. If the initial dose does not cause any intolerance, tbe following dose can be administered as a 30minute infusion; sbould not administer as an intravenous pusb or bolus_ In clinical studies, patients were treated witb trastuzumab until progression of disease_ Elderly: Data suggest tbat tbe disposition of trastuzumab is not altered based on age_ Storage: Store vials at 2_8°C. Reconstituted solution is stable for 28 days wben stored refrigerated at 2·8°C. Tbe reconstituted solution contains preservative and is tberefore suitable for multiple use.

and cerebral hemorrhage.

syndrome (RAS): In up to 25% of patients with

APL treated with retinoic acid, a syndrome occurs

which can be fatal. High dose dexamethasone for 2-3 days should be initiated immediately.

Anthracycline based chemotherapy can be added

when WBC counts are higher (5x 109/1).

Pregnancy & lactation: Retinoic acid should not be used during pregnancy and lactation. Effective contraception must be used by all females during

retinoic acid therapy and for I month following discontinuation of therapy.

Dosage & admin: Tbe recommended dose is 45mglm2lday administered as two equally divided doses until complete remission is documented_ Tberapy sbould be discontinued 30 days after acbievement of complete remission or after 90 days of treatment, wbicbever occurs first. Note: Full details are available from the manufacturing authority on request. l OO's pack: 25875.00 MRP

(Price c@uld not be revised).

TRASTUZUMAB50 :.

•

HERCEPTIN Inj_ Rocbe

Trastuzumab 440mglvial; powder for concentrate solution for infusion; reconstituted concentrate solution contains 21 mglml of trastuzumab.

Ind: Trastuzumab is indicated for the treatment

of patients with metastatic breast cancer who

have tumors that overexpress HER2: a) in

combination with chemotherapy as first-line

treatment of those patients who have not received

chemotherapy for their metastatic disease, b) as monotherapy who have pre-treated with

chemotherapy.

CII: Trastuzumab is contraindicated in patients

with known hypersensitivity to trastuzumab or to any other component of the product.

SIE: The most common adverse reactions are

potential risk to the fetus.

440mg vial x I's pack: 1 5 500.00 MRP (Price could not be revised).

2. DRUGS AFFECTING THE IMMUNE RESPONSE2 1 2.1 CytotoxiC immunosuppressants· viz. Azathioprine, Myeophenowte mofetil 2.2 Corticosteroids & other immunosuppressants· viz. Prednisolone, eyelosporin, Basiliximab, Taerolimus 2.3 Rituximab· viz. Rituximab 2.4 Interferons· viz. Interferon alja, Interferon beta 2.5 Aldesleukin· viz. Aldesleukin

2.1 Cytotoxic Immuno

suppressants AZATIDOPRINE47

infusion-related symptoms, such as fever and chills, usually follOWing the first infusion of

.:. IMURAN Tab. GlaxoSmithKline

trastuzumab.

Azathioprine 50mg/tablet.

dysfunction, such as dyspnea, orthopnea,

transplant recipients and are also used to treat a

admin. of allopurinol, cytostatics and muscle Adult

& Child: by mouth, 1-5 mglkg body-wt

1 00's pack: 1 394.00 MRP

MYCOPHENOLATE MOFETIL / MYCOPHENOLIC ACID21.5o,54 MYCOPHENOLATE MOFETIL I MYCOPHENOLIC ACID: Tabietiinjection Mycophenolate mofetiVmycophenolic acid (as sodium salt) is an immunosuppressive agent.

Mycophenolate mofetil is available as 500mg

tablet for oral administration. Injection

preparation is not yet available in our market.

Mycophenolic acid is available (as sodium salt)

1 80mg or 360mg tablet (gastroresistant) for oral

administration.

Equivalence: Mycophenolic acid nOmg is

approximately equivalent to mycophenolate

mofetil 1 9m, but avoid unnecessary switching

because of pharmacokinetic differences.

Ind: Renal & cardiac transplant: Mycophenolate mofetiVmycophenolic acid (as sodium salt) is

indicated for the prophylaxis of organ rejection and for refractory organ rejection in patients

receiving allogeneic renal transplants and in

patients receiving allogeneic cardiac transplants.

CII: Mycophenolate mofetiVmycophenolic acid

(as sodium salt) is contraindicated in patients

hypersensitive to this drug or any of it's components.

SIE: The principal adverse reactions associated with the administration of mycophenolate

mofetiVmycophenolic acid include diarrhoea,

constipation, leukopenia, sepsis and vomiting.

Most common undesirable side effects are CMV infections, upper respiratory tract and skin

infections, cold sores, unexpected heartburn and

unexpected bruising and bleeding.

Precautions & warnings: Patients receiving immunosuppressive regimens involving

combinations of drugs, including mycophenolate

mofetil or mycophenolic acid (as sodium salt), as part of an immunosuppressive regimen are at

increased risk of developing lymphomas and

other malignancies, particularly of the skin. As

usual for patients with increased risk for skin

cancer, exposure to sunlight and ultra-violet light should be limited by wearing protective clothing

and using a sunscreen with a high protection

factor. Patients should be given complete dosage instructions and informed of the incrased risk of

Iymphoproliferative disease and certain other

malignancies.

Safety and effectiveness in pediatric patients have not been established.

Pregnancy & lactation: Women of childbearing

Ind: Cytotoxic immunosuppressants for

potential should be instructed of the potential

increased cough, pulmonary edmea, S3 gallop,. or

variety of auto-immune and collagen diseases,

effective contraception before beginning

patients treated with trastuzumab.

provided inadequate control.

thrombocytopenia and anemia occurring in occasionally hypercalcae-mia. Visual disturbance

these experiences to drug treatment has been

made and some Qf the experiences reported are

those that commonly occur in elderly patients.

These include: Heart failure; anorexia, dry

mouth, dyspepsia, constipation, flatulence;

headache, dizziness, insomnia, somnolence,

decreased libido; dyspnoea; impotence, nocturia; anaemia; alopecia. rash, sweating, hirsutism;

Pregnancy & lactation: As this drug is indicated

on long term therapy.

diabetes mellitus, hyperglycemia, oedema, weight

postmenopausal women, this is not applicable for

term therapy. See also under Alkerim.

chest pain, pelvic pain, chills.

for the treatment of breast cancer in using in pregnancy

& lactation.

Dosage & admin: lmg (one tablet) to be taken orally once a day Drug inter: Co-administration of anastrozole with other drugs (e.g antipyrine and cimetidine)

is unlikely to result in clinically significant drug

Caution: Monitor for visual disturbances on long

Pregnancy & lactation: Contra-indicatied. Dosage & admin: Adult: 20mg daily increasing to 40mg daily if necessary (in divided doses). For anovulatory infertility 20mg daily on four successive days commencing on 2nd day of menstruation. Increase if necessary to 40mg

gain, weight loss; body pain, abdominal pain,

Precautions & warnings: Bicalutamide is extensively metabolised in the liver, so

bicalutarnide should be used with caution in patients with moderate to severe hepatic

impairment. Periodic liver function tests should

be considered due to the possibility of hepatic

]he first line treatment 'or '; � ER'positive_ breast cancer

�

.

. .

QIMP-15 (376)

CARCINO-CHEMOTHERAPEUTIC DRUGS changes. The majority of changes are ,expected to

analogues. Pregnancy and lactation.

therapy.

generally mild. arthralgia. Changes in blood

occur within the first 6 months of bicalutamide

SIE: Rarely hypersensitivity, skin rashes;

hormone somatostatin (i.e somatostatin analogue).

Mode of action: Octreotide acetate (sandostatin) is an even more potent inhibitor of growth

pressure. Occasional mild bruising at injection

hormone, glucagon, and insulin than

therapy should be discontinued.

Males: Hot flushes, decrease in potency,

suppresses LH response to GnRH, decreases

indicated in females and must not be given to

temporary increase in bone pain, isolated case of

-Severe hepatic changes have been observed

site.

rarely with bicalutamide, and in that case,

Pregnancy & lactation: Bicalutamide is contra

infrequently breast swelling and tenderness;

somatostatin. Like somatostatin, it also

splanchnic blood flow, and inhibits release of

serotonin, gastrin, vasoactive intestinal peptide,

ureteric obstruction and spinal cord compression

secretin, motilin, and pancreatic polypeptide.

tablet) once a day_ Treatment with

Females: Hot flushes and

octreotide acetate (sandostatin) has been used to

time as treatment with an LHRH analogue

depression, change in breast size. Temporary

No dosage adjustment is necessary for patients

fibroids.

pregnant women or nursing mothers.

Dosage & admin: Adults & elderly: 50mg (one

bicalutamide should be started at the same (such as goserelin) or surgical castration_

have been recorded.

sweating, change in

libido, headaches, mood changes including

increase in signs and symptoms. Degeneration of

with renal impairment, and for patients with

Precautions: Males: Use in patients at particular

accumulation may occur in patients with

core compression should be considered c3Jefully

Children: Bicalutamide is,cantra-indicated in

therapy.

mild hepatic impairment. Increased

moderate to severe hepatic impairment.

chidren_

Females: Exclude pregnancy before

treatment. Non-hormonal contraception should be

density, which may recover on cessation of therapy. Caution in women with known

50mg x 28's pack: 16814.84 MRP

metabolic bone disease. Increase in cervical

GOSERELIN95

sustained release depot. It is supplied as a single

dose pre-filled syringe applicator (with a

comtains a desiccant) to be administered every 4 weeks.

Mode of action: Goserelin is a synthetic (luteinizing hormone releasing hormone). On chronic administration, goserelin results in

inhibition of pituitary LH secretion leading to a

, fall in serum estrogen and testosterone

concentrations in women and men, respectively.

Initially, there may be a transient increase in

serum sex steroid hormone concentration. By around 2 1 days after the first depot injection,

estrogen or testosterone concentrations fan to

within castrate range and remain suppressed with

continuous treatment every 28 days. This

inhibition leads to breast or prostate tumour

regression and symptomatic improvement in the majority of patients.

Iud: 1. Prostate cancer - Goserelin is indicated in

for

Goserelin is indicated in the management of

breast cancer in pre/Ilenopausal and

perimenopausal. women suitable for hormonal manipulation. 3. Endometriosis - in the

mangement of endometriosis, goserelin alleviates symptoms, including pain and reduces the size

reduces growth hormone and/or IGF-I

(somatomedin C) levels in patients with

. acromegaly.

Single doses of octreotide acetate (sandostatin)

have been shown to inhibit gallblader

contractility and to decrease bile secretion in

normal volunteers. In controlled clinical trials the ' incidence of gallstone or biliary sludge formation

was markedly increased.

Ind: Emergency management to stop bleeding

increase in benign pituitary tumours has been

esophageal varices in patients with cirrhosis,

repeated dosing (relevance to man not

endocrine tumors.

benign proliferative condition in the pyloric

any component of the formulations.

observed in male rats following long-term

region of the stomach observed in mice following

secretion of thyroid stimulating hormone (TSH). and to protect from re-bleeding owing to gastro

acromegaly, control of symptoms of neuro

CII: Known hypersensitivity to octreotide or to

Precautions: Please see manufacturer's literature.

long-term repeated dosing with human dose

Pregnancy & lactation: Experience with

evidence that goserelin results in impairment of

limited, and they should therefore be given the

(relevance to man is unknown). There is no

analogue of naturally occurring LHRH

adenomas (watery diarrhea).

Octreotide acetate (sandostatin) substantially

of treating benign endometriosis conditions with

established). Pancreatic islet cell hyperplasia and

protective sleeve in a sealed pouch which

vasoactive intestinal peptide (VIP) secreting

Octreotide acetate (sandostatin) suppresses

goserelin for periods in excess of six months. An

Each pre-filled injection contains goserelin

acetate equivalent to 3.6mg peptide base in a

treat the symptoms associated with metastatic

carcinoid tumors (flushing and diarrhea), and

resistance, requiring care if dilating the Cervix.

Currently, there are no clinical data on the effects

.:. ZOLADEX Inj. AstraZenecalACI

hormonal manipulation. 2. Breast cancer -

and patients monitored during first month of

employed during therapy. Loss of bone mineral

Drug inter: Please consult manufacturer's

literature.

the management of prostate cancer suitable

risk of developing ureteric obstruction or spinal

By virtue of these pharmacological actions,

ability to drive or operate machinery.

sandostatin in pregnant or nursing women is drug only under compelling circumstances.

Pregnancy & lactation: Goserelin is

SIE: Anorexia, nausea, vomiting, crampy

Dosage & admin: Adults: One 3.6mg depot

loose stools, diarrhoea, steatorrhoea,

contraindicated during pregnancy

& lactation.

goserelin injection to be given subcutaneously into the anterior abdominal wall, every 28

days. No dosage adjustment is necessary for

patients with renal & hepatic impairment. No dosage adjustment is necessary

in the elderly.

abdominal pain, abdominal bloating flatulence, hypersensitivity, isolated cases of bradycardia.

Dosage & admin: 50mcg (1 ampoule)

or subcutaneously followed by 25mcg

IV bolus ('/2

ampoule)/hour in continuous infusion (total of 12 ampoules in 1000ml of NS, DA or DNS to

Children: Goserelin is not indicated for use in

be infused over 24 hours) for 3-5 days.

Drug inter: Please consult manufacturer's

to room temperature before administration.

children.

literature.

Storage: Store below 25°C.


3.6mg pre-filled syringe x I 's pack: 15082.39

MRP

Hormone Antagonists

The injection should be inspected and brought

Overdose: Doses of up to 2000mcg octreotide given as s.c. injection t.i.d. for several months

have been well tolerated. The maximum i. v.

single dose so far given to an adult has been Img

by bolus injection. The signs and symptoms

observed were a brief drop in heart rate, facial

flushing, abdominal cramps, diarrhoea, an empty

feeling in the stomach, and nausea, all of which

r�solved within 24 hours of drug administration.

Drug inter: Sandostatin has been associated with

Somatostatin analogues

alterations in nutrient absorption, so it may have

with fibroids prior to surgery. 5. Endometrial

OCTREOTIDE54,1 45

with cycIosporine may decrease blood levels of

prethinning of the uterine endometrium prior to

.:. SANDOSTATIN SC Inj. Novartis

Patients receiving insulin, oral hypoglycemic

and number of endometrial lesions. 4. Uterine

fibroids - in conjunction with iron therapy in the

haematological improvement of anaemic patients thinning - Goserelin is indicated for the

endometrial ablation or resection. 6. Assisted

. reproduction. (Pituitary downregulation in 'preparation for superovulation).

CII: Hypersensitivity to goserelin or other LHRH

an effect on absorption of orally administred

drugs. Concomitant admnistration of sandostatin

cyclosporine and result in transplant rejection.

Octreotide acetate 50mcgll ml ampoule:

, subcutaneous. injection.

Octreotide acetate is a long-acting octapepiide

with pharmacologic actions similar to the natural

agents, beta blockers, calcium chamel blockers,

or agents to control fluid and electrolyte balance,

may require dose adjustments of these

therapeutic agents.

QIMP-15 (377)

Note: For full information_ please consult

manufacturer's literature. 50mcg ( I ampoule) x 5's pack: 6200.00 MRP

4. DRUGS FOR CHEMOTHERAPY INDUCED NEUTROPENIA

FILGRASTIM50 .:. NEUPOGEN Inj_ Roche Filgrastim- recombinant human granulocyte colony stimulating factor (rHuG -CSF), 30 million unitsllml ampoule: injection Ind: For the reduction of duration of neutropenia and incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for nonmyeloid malignancy; reduction in duration of neutropenia in myeloablative therapy followed by bone-marrow transplantation; mobilisation of peripheral blood progenitor cells for harvesting and subsequent autologous infusion; severe congenital neutropenia; cyclic neutropenia or idiopathic neutropenia. CII: Known sensitivity to the product or its constituents. Severe congenital neutropenia with abnormal cytogenetics (Kostman's syndrome). Filgrastim should not be used to increase doses of cytotoxic chemotherapy beyond established regimens. S/E: Musculoskeletal pain (alleviated by standard analgesics); urinary abnormalities (predominantly dysuria); reversible dose dependent elevations of lactate dehydrogenase, alkaline phosphatase, serum uric acid, and gammaglutamyl transpeptidase. There have been occasional reports of decrease of blood pressure, but not requiring clinical treatment. Precautions: Safety and efficacy have not been established in myelodysplasia, acute myelogenous leukaemia, or chronic myelogenous leukaemia. Exercise caution in any malignant or premalignant myeloid condition. Leucocytosis (WBC> 1 00 x 1091L) has been seen at doses seen above 0.3 million units (3mcg)Jkglday in less than 5% of patients. In addition, as higher doses of chemotherapy may be administered, resulting in an increased risk of thrombocytopenia and anaemia, regular haematological monitoring is recommended. For sustained response, filgrastim should be continued until after the expected nadir and until the neutrophil count has recovered. Bone density monitoring is advised for patients with osteoporotic disease receiving filgrastim for longer than 6 months. Use of filgrastim in severe renal or hepatic impairments is not recommended. Pregnancy & lactation: No evidence of teratogenicity but increased embryo-loss has been seen in rabbits. Administer to expectant mothers only if benefits is likely to exceed potential risk to foetus. Not recommended in nursing mothers. Dosage & admin: Cytotoxic-induced neutropenia- adult & child, 0_5 million units (5mcg)/kglday (first dose started not less than 24 hours after chemotherapy) as a daily soc

injection or Lv infusion (over 30 minutes)_ Treatment should be continued until neutrophil count in normal range, usually for up to 14 days (up to 38 days in acute myeloid leukaemia)_ Elderly- no specific dosage recommendations are made_ In patients treated with cytotoxic chemotherapy & outologous bone-marrow transplantation- the recommended starting dose of filgrastim is 1 million units (lOmcg)/kglday given by continuous s.c infusion over 24 hours or by continuous Lv infusion over 30 minutes or over 24 hours (first dose started not less than 24 hours after chemotherapy & within 24 hours of bone marrow infusion), Mobilisation of peripheral blood progenitor cells- used alone, by soc injection or infusion over 24 hours, 1 million unitsJkglday for 6 days; used following adjunctive myelosuppressive chemotherapy (to improve yield), by soc injection, 0,5 million units/kglday started the day after completion of chemotherapy & continued until neutrophilo count in normal range. Severe chronic neutropenia- adult & child, by s.c injection, in severe congenital neutropenia, initially 1.2 million units/kglday in single or divided doses, (in idiopathic or cyclic neutropenia, initially 0_5 million unitsJkglday) adjusted according to response. Filgrastim may be diluted in 5 % glucose i.v solution BP, Dilution below 0.2 million units (2mcg)/ml is not recommended. When diluted below this range, add human serum albumin to a fmal concentration of 2mcglml. Diluted nIgrastim solution should not be prepared more than 24 hours before use_ Filgrastim and diluted fIigrastim solutions should be stored at 2- 8°C. Filgrastim should not be diluted with saline_ Filgrastim is for soc or i.v administration. Sites of s_ c injection should be varied. Drug inter: Administration of filgrastim is not recommended in the period 24 hours before to 24 hours after chemotherapy. 30 MIU ( l ml) amp x I's pack: 6 1 87.50 MRP (Price could not be revised).

LENOGRASTIM35.50 .:. GRANOCYTE 34 MIU Inj. Sanofi-aventis Lenograstim- recombinant human granulocyte colony stimulating factor (rHuG-CSF). Each vial contains 33.6 million units (263mcg) as powder for reconstitution in Iml water for injection. Ind: Reduction in duration of neutropenia and associated complications in patients undergoing bone-marrow transplantation or cytotoxic chemotherapy with febrile neutropenia, and mobilisation . of peripheral blood progenitor cell (PBPCs). CII: Known hypersensitivity to product or constituents. Not to be used for intensification of cytotoxic chemotherapy beyond established regimens. Not to be administered concurrently with cytotoxic chemotherapy or to patients suffering from myeloid malignancy. Not recomm-ended in pregnancy & nursing women.

CARCINO-CHEMOTHERAPEUTIC DRUGS

S/E: Musculoskeletal pain (alleviated by standard . analgesics); asthenia; abdominal pain & generalised pain reported in healthy donors. Urinary abnormalities (predominantly dysuria). Reversible dose-dependent elevations of lactate dehydrogenase, alkaline phosphatase, serum uric acid, and gammaglutamyl transpeptidase. There have been occasional reports of decrease of blood pressure, but not requiring clinical treatment. Precautions: Safety and efficacy have not been established in myelodysplasia, acute myelogenous leukaemia. or chronic myelogenous leukaemia. Exercise caution in any malignant or premalignant myeloid condition. Leucocytosis (WBC> 1 00 xI 09/L) has been seen at doses seen above 0.3 million units (3mcg)Jkg/day in less than 5% of patients. In addition, as higher doses of chemotherapy may be administered, resulting in an increased risk of thrombocytopenia and anaemia, regular haematological monitoring is recommended. For sustained response, lenograstim should be continued until after the expected nadir and until the neutrophil count has recovered. Bone density monitoring is advised for patients with osteoporotic disease receiving lenograstim for longer than 6 months. Use of lenograstim in severe renal or hepatic impairments is not recommended. Pregnancy & lactation: Risk to human foetus unknown. Some abortifacient effect in rabbits has been seen. Not reconunended in nursing women. Dosage: Granocyte 34 (33_6 million units/vial) is used in patients with body surface area up to 1.8 m2_

Bone-marrow transplantation: adult & child over 2 years- the recommended dose is 19_2 million units (150mcg)/m2/day, start treatment 24 hours after transplantation by i_v infusion in 30minutes, diluted in isotonic saline solution; the treatment should be continued until neutrophil count stable in acceptable range (max_ 28 days)_

Cytotoxic chemotherapy induced neutropenia: adult & child over 2 years- by soc injection, 19_2 million units (150mcg)/m2/day, start treatment 24 hours after completion of chemotherapy; treatment should continue until neutrophil count stable in acceptable range (max_ 28 days).

PBPCs mobilisation: when lenograstim is used alone, by soc injection, 1.28 million units (10mcg)/kglday for 4-6 days (5-6 days in healthy donors); used following adjunctive myelosuppressive chemotherapy (to improve yield), by soc injection, 19_2 million units (150mcg)/m2/ day, start treatment 24 hours after completion of chemotherapy & continue treatment until neutrophil count stable in acceptable range_ Leukapheresis should be performed between day 5 and 7, In both cases, one leukapheresis is often sufficient to obtain the acceptable minimum yield (? 2_0 x 106 CD34+ cells per kg)_

Elderly: As per adult dose_ Children: As per adult dose, safety demonas-trated in children

CARCINO·CHEMOTHERAPEUTIC DRUGS

older than 2 years in bone marrow transplantation. Administration: Granocyte is for s.c or i.v administration following reconstitution with water for injection. After reconstitution, Granocyte should be

IMMUNOLOGICAL

PRODUCTS & VACCINES Drugs discussed in this chapter include:

L Bacterial & Viral vaccines a) Chicken pox vaccine

b) Diphtheria vaccine c) Diphtheria, Pertussis & Tetanus (DPT) mixed vaccine d) DPT + HB combined vaccine e) Hemophilus Influenzae vaccine

f) Hapatitis-A virus vaccine

g) Hapatitis-B virus vaccine h) Measles vaccine i) Meningococcal vaccine j) Mumps vaccine k) MMR vaccine I) Pertussis vaccine m) Poliomyelitis vaccine n) Rabies vaccine 0) Tetanus vaccine p) Thberculosis vaccine q) Typhoid fever vaccine 2. Immunogolbulin Prepns. a) Human normal immunoglobulins b) Human specific immunoglobulins i) Hapatitis B immune globulins ii) Human anti-tetanus immunoglobulin iii) Human anti-D immunoglobulins

Bacterial & Viral Vaccines CHICKEN POX83 .:. VARILRIX Inj. GlaxoSmithKline Varilrix is a Iyophilised preparation of the live attenuated Oka strain of varicella-zoster virus, obtained by propagation of the virus in MRC human diploid cell cultre. Each dose of the reconsituted vaccine contains not less than 10 plaque-fonning units (PFU) of the attenuated varicella-zoster virus. Ind: Active immunisation against varicella of healthy subjects from the age of 1 2 months onwards; active immunisation against varicella of susceptible high-risk patients and their susceptible healthy close-contacts.

QIMP·15 (378)

stored at 2 to goC and used within 24 hours. For Lv infusion, Granocyte should be diluted in 0.9% NaCI solution. Granocyte 34 (33.6 million units/vial) should not be diluted below 1 vial into 100ml. Granocyte vials are for single dose use only.

S/E: In healthy subjects- side-effects are very low and rare in all age groups. In age group 9 mono to 12 years: papulov-esicular eruptions (4%); mild fever (5%). In age group 13 years & above with a 2-dose schedule-no papulo-vesicular eruptions have been reported. General symptoms, such as headache, fever, paresthesia & fatigue are reported in 2.S% cases after each dose. In high-risk patients, papulo-vesicular eruptions, rarely accompanied by mild to moderate fever as in leukaemic patients (less than a quarter of patients). The appearanec of these eruptions do not influence the clinical mamagement of the patients. Precautions & warnings: After reconstitution, Varilrix TM should be administered immediately. Alcohol and other disinfecting agents must be allowed to evaporate from the skin before injection of the vaccine since they may inactivate the viruses. As with all injectable vaccines, appropriate medical treatment should always be readily available in case of rare anaphylactic reactions following the administration of the vaccine. For this reason, the vaccinee should remain under medical supervision for 30 minutes after immunisation. Varilrix should not be administered intradermally & under no circumstances be administered intravenously. Dose & Admin: 0.5ml of reconstituted vaccine contains one imrnunising dose. From the age of 12 months up to and including 12 years of age: 1 dose. 13 years & above: 2 doses with an interval of 6 to 10 weeks. The same schedule should be applied for the high-risk patients also. In these patients, periodic measurement of varicella antibodies after vaccination may be indicated in order to identify those who may benefit from revaccination. Administration: Varilrix is for subcutaneous use only. Drug inter: Subjects who have received immunoglobulins or a blood transfusion, immunisation should be delayed for at least three months because of the likelihood of vaccine failure due to passively acquired varicella antibodies. Varilrix can .be administered at the same time as any other vaccines. Different injectable vaccines should always be adiminstered at different injection sites. But, measles vaccine should not be given at the same time as Varilrix, at least at an interval of one month, since it is recognised that measles vaccination may lead to short Iived supperssion of the cell mediated immune response.

Drug interaction: Treatment not recommended from one day before until one day after chemotherapy. Interactions with other haemopoietic growth factors and cytokines not established. 34 million units vial: 7355.25 MRP

In high-risk patients, Varilrix should not be administered at the same time as other live attenuated vaccines. Inactivated vaccines may be administered in any temporal relationship to Varilrx, given that no specific contra-indications had been established. 0.5ml dose vial: 1324.00 MRP

CHOLERA VACCINE2l CHOLERA VACCINE: Injection Vaccines contain heat killed inaba and ogawa SUbtype of cholera bacteria; I ml & I .Sml ampoule and 10ml & SOml vial. Ind: Active immunisation against cholera. Period of immunity-6 months Dosage & admin: Adult: First dose-0.5ml s. c. or L m. 2nd dose- 1ml s.c. or Lm (or 0.2ml intradermally) after 4 weeks (or 7days if rapid immunisation is necessary ) Child: First dose- under 1 year not recommended; 1-5 years 0.1 ml s. c. or i. m; 5-10 yrs, 0.3ml s. c. or i. m. 2nd dose- 1-5 yrs, 0.3ml s. c. or L m . (or O.lml intradermally) ; 5-10 yrs, 0.5ml s. c. or L m. (or O.lml intradermally). Interval, same as adult. Booster dQse- necessary after 6 months; give the same as 2nd dose. Preparation: May not be available.

DIPHTHERIA VACCINE>l ,33 .:. ADS Inj. Behring Diphtheria antitoxin (Anti-diphtheric serum) 20,000 i. ulampoule Ind: Passive immunisation (after exposure) and treatment of diphtheria. Dose: Prophylaxis- 500-2000 L u, s. c or i. m injection. Therapeutic-10000 to 30000 L u. by L m injection, or 40000 to 100000 i. u. by i. v. injection in 2 divided doses with an interval of 112-2 hours. Sml vial: 182.55 MRP Preparation: May bot be available; price could not be revised.

DIPHTHERIA, PERTUSSIS & TETANUS (DPT) MIXED VACCINE>! ,33 DIPHTHERIA, PERTUSSIS & TETANUS (DPT): Injection Diphtheria, Tetanus and Pertussis vaccine prepared from diphtheria formol toxoid, tetanus formol toxoid and pertussis vaccine (killed B pertusis not less than 4 i. u. from not more than

QIMP-15 (379) 20000 million organismsiO.5ml); 0.5 ml ampoule:

sickness like disease, have been reported.

Injection.

Convulsions and thrombocyto-penia have been

Ind: Active immunisation against diphtheria,

reported very rarely with hepatitis B containing

IMMUNOLOGICAL PRODUCTS & VACCINES

HAEMOPHILUS INFLUENZAE VACCINE35.83

tetanus and pertussis.

vaccines.

CII: Acute febrile illness; history of convulsions,

Fatigue, malaise, headache, arthralgia, myalgia

.:. ACT-HIB Inj. Sanofi-aventis

cerebral irriation or damage in the neonatal

and urticaria have also been reported.

Freeze-dried Haemophilus intluenzae type b

period. Severe local or general reaction to a

Precautions & warnings: Persistent crying

polysaccharide conjugated to tetanus protein

preceeding dose. History of neurological disease, family epilepsy and history of severe allergy.

Child: Under 5 yrs, primary immunisation-3 doses of 0.5ml vaccine by i. m or deep s.c injection, each dose at an interval of minimum 4 weeks; Over 5 yrs, not recommended.

: D,P,T Vaccine Behring werke

•.

Diphtheria, Tetanus and Pertussis vaccine; 0.5 ml ampoule: injection 10 amps pack: 1 79.50 MRP (Price: could not be revised).

.:. DPT Vaccine Chairon SPA

Diphtheria, Tetanus and Pertussis vaccine; 0.5 ml ampoule: injection 1 amp pack: 1 5 .35 MRP (Price: could not be revised).

: D,T Vaccine Behring werke

•.

A mixture of Diphtheria formol toxoid and tetanus formol toxoid; 0.5ml ampoule: injection.

Ind: Active immunisation against diphtheria and tetanus.

CII: See under D.P.T vaccine. Dose: Re-inforeing (or booster) doses for children , O,Sml by i. m or deep s, c injection_ 1 amp of 0.5 ml: 1 7.50 MRP (Price: could not be revised).

DPT + HB COMBINED VACCINE .:. TRITANRIX HB Inj, GlaxoSmithKline Tritanrix HepB, a combination vaccine of DPT and Hepatitis B; 0.5mllvial: injection. Tritanrix HB vaccine contains diphtheria, tetanus toxoids, inactivated pertussis bacteria and the purified major surface antigen of the hepatitis B virus (HBV), adsorbed on aluminium salts.

Ind: Tritanrix HB is indicated for active immunisation against diphtheria, pel1ussis, tetanus, and hepatitis B in infants from 6 weeks onwards.

CII: Known hyersensitivity to any component of the vaccine, or history of hypersensitivity after administration of diphtheria, tetanus, pertussis or HB vaccines previously. ii. Acute severe febrile illness. iii. child suffering from encephalopathy of unknown aetiology, occurring within 7 days following previous vaccination with pertussis containing vaccine. In these circumstances the vaccination course should be continued with DT and Hb vaccines. iv. Collapse or shock-like state (hypotonic-hyporesponsive episode) within 48 hours. v. convulsions with or without fever, occurring within 3 days.

SIE: Unusual crying, drowsiness, irritability, gastrointestinal symptoms and feeding problems were observed during clinical trials. These events were reported within 48 hours and in less than 5.0% of the cases were considered as severe. Fever was recorded in 40% but in most

lasting >3 hours, occurring within 48 hours. There may be circumstances, such as a high incidence of pertussis, when the potential benefits outweigh possible risks. Trianrix hepb should under no circums-tances be administered intravenously.

Dosage & admin: the recommended dose (O'sml) of the vaccine must be administered by deep intramuscular (Lm) injection, preferably in the anterolateral part of thigh, In patients with thrombocytopenia or bleeding disorders, the vaccine should be admini-stered subcutaneously. The primary vaccination schedule consists of 3 doses within the first six months of Iife_

Vaccination schedule & booster dose:

Where hepatitis B vaccine is not given at birth, the comhined vaccine can be administered beginning as early as 8 weeks of age. Where there is a high endemicity of hepatitis B, the practice to administer hepatitis B vaccine at birth should be continued, In these circums-tances, vaccina-tion with the combined vaccine should start at 6 weeks of age. 3 vaccine doses must be administered at intervals of at least 4 weeks, At this moment, insufficient data are available to snpport the recommendation of a booster dose of the combined vaccine, The administration of a booster dose with DPT vaccine is recommended before the end of the second year of life, For longterm protection, a booster dose of HB vaccine could also be administered after the first year of life. However, the need for this dose is currently not established,

Vaccination for infants bam to HRs Ag+positive mothers:

In the case of children born of known hepatitis B carrier mothers the immunoprophylactic measures for hepatitis B should not be modified, This may require separate vaccination with hepatitis B and DPT vaccines and also include the administration of HBIg at birth, Drng inter: Previous experiences with simultaneous administration of DPT, OPV and HE vaccines have not shown any intelference. no interference in the immune response to any of

the antigens was observed as compared to the responses observed following adminis-tration of the vaccines at separate sites. In patients receiving immunosuppressive therapy or patients with immunodeficiency, an adequate response may not be achieved. Shelf-life: The tritanrix HB vaccine should be stored at a temperature between +2°C to +9° C. when the vaccine is stored under prescribed

1 0mcg/vial. Other ingredients- trometamol 0.6mg

& saccharose 42.5mg/vial. Single dose presentation with diluent for injection 0.5ml: s.c or i.m injection

Ind: Act-HIB is indicated for the prevention, in infants from 2 months, of invasive di.seases caused by H. intluenzae type b (viz. meningitis, septicaemia, cellulitis, arthritis, epiglottitis etc) . Act-HIB does not protect against infections due to other types of H. intluenzae, nor against other

g

menin itis of other origins.

CII: Subjects with known hypersensitivity to any component of the vaccine, particu-Iarly the tetanus protein, or to subjects having shown signs of hypersensitivity with administration of Hib vaccines. Fever or acute infection (a minor infection is not contraindicated) .

SIE: No serious local or general reaction observed following administration of the vaccine. The reported local signs/symptoms that occur within the first 48 hours are mild redness, swelling and pain at the site of injection, which resolves spontaneously. The general symptoms that reported within the first 48 hours are fever, loss of appetite, restlessness, vomiting, diarrhoea and unusual crying, wich are also mild and resolves spontaneously.

Precautions & Warnings: As with all injectable vaccines, appropriate medical treatment and supervision should always be readily available in case of a rare anaphylactic event following the administration of the vaccine. For this reason, medical supervision should continue for 30minutes after immunistion. Although limited immune response to the tetanus toxoid component may occur, vaccination with ACT HIB alone does not subsitute for rutine tetanus vaccination.

Dosage & admin: Primary vaccination: from 2 months- 3 injections at 1 or 2 months intervals followed by a booster 12 months after the third dose, Second chance vaccination: when it has not been possible to give the child a primary vaccination- (i) between 6 and 12 months: 2 injections at 1 or 2 months intervals followed by a booster 12 months after the second dose; (ii) from l2 months and up to 5 years: a single injection. Drug inter: ACT HIB can be administered either simultaneously or at any time before or after a different inactivated or live vaccine. Other injectable vaccines should always be administered at different injection sites. In patients receiving immunosuppressive therapy or patients with immunodefici-ency, an adequate response may not be achieved. 10 vials pack with diluent: 5400.00 MRP

cases it was mild to moderate. These events

conditions the shelf-life is 36 months.

.:. HIBERIX Inj. GlaxoSmithKline

lasted only for a few days.

Note: For further information, see below under

Hiberix is a vaccine for Haemophilus influenzae

Very rare anaphylaxis, allergic reactions

the text of Hepatitis B vaccine.

type b (Hib). It is a Iyophilised vaccine of

including anaphylactoid reactions and serum

0.5ml vial: 393.00 MRP

purified polyribosyl-ribitol-phosphate capsular

QIMP-15 (380)

IMMUNOLOGICAL PRODUCTS & VACCINES polysaccharide (PRP) of Hib. Each single dose of

limited immune response to the diphtheria toxin

vaccine is formulated to contain 10mcg of

component may occur, vaccination with Vaxem

purified capsular polysaccharide, covalently

Hib does not substitute for routine diphtheria

bound to approximately 30mcg tetanus toxoid.

vaccination. Vaxem Hib does not elicit protection

Ind: Active immunisation of all infants from the

against diseases caused by other H. influenzae

age of 6 weeks against Hib infection disease (viz.

serotypes and does not protect against meningitis

meningitis, septicaemia, cellulitis, arthritis,

caused by other pathogenic agents. Vaxem Hib

epiglottitis etc). Hiberix does not protect against

should under no circumstances be administered

infection due to other types of H. influenzae nor

intravascularly.

against meningitis caused by other organisms.

AIR: Primary courses in infants 2-6 months of

CII; SfE; Cautions: See above under ACT HIB vaccine.

Dosage & Admin: The primary vaccination schedule consists of three doses in the first 6 months of life and can start from the age of 6 weeks. Infants between the ages of 6 and 12 months previously unvaccinated should receive 2 injections� given with an interval of one month, followed by a booster in the second year of life. Previously unvaccinated children aged 1-5 years should be given one dose of vaccine. To ensure a long-term protection, a booster dose is recomme-nded in the second year of life, As vaccination schemes vary from country to country, the schedule for eah country may be used in accordance with the different national recomme-ndations.

Method of administration: The reconstituted vaccine is for intramuscular injection, and under no circumstances be administered intravenously.

influenzae type b conjugate vaccine. It is

Tenderness, erythema, induration, unusual crying,

suspension for injection in prefilled syringe.

ilTitability, vomiting, diarrhoea, change in eating

Compo Each single dose of 0.5ml ampoule

habits, sleepiness, fever; Common ( I % and

contains: Diphtheria toxoid ;0,30 iu; Tetanus

< 1 0%): Rash, agitation; Uncommon: Screaming

toxoid ;0,40 iu; Bordetella pertussis antigens toxid

syndrome. Primary courses in children 1 2 - I S

25mcg; Filamentous haemagglutinin 2Smcg;

months o f age: Adverse reactions (onset within 6

inactivated type 1 poliomyelitis virus D antigen

days of primary vaccination): Very common

40 units, inactivated type 2 poliomyelitis virus D

( 1 0%): Unusual crying, irritability, vomiting,

antigen 8 units, inactivated type 3 poliomyelitis

diarrhoea change in eating habits, sleepiness,

virus D antigen 3 2 units; Haemophilus influenzae

fever; Common ( 1 % and < 1 0% ) : Tenderness;

type b polysaccharide (conjugated to tetanus

Uncommon: Rash, erythema, induration. B ooster

protein) 1 0mcg.

dose in children 16-20 months of age: Adverse

Ind: This vaccine is indicated in the combined

reactions (within 6 days of booster dose): Very

prevention of invasive infections caused by

common ( 1 0%): Irritability; Common ( I % and

haemophilus influenzae type b (meningitis,

< 1 0%): Vomiting, diarrhoea, change in eating

septicaemia, cellulitis, arthritis, epiglottitis etc.),

habits and sleepiness; Uncommon: Agitation,

diphtheria, tetanus, pertussis and poliomyelitis

unusual crying and rash.

for primary vaccination in infants over 4 months

administration of vaxem Hib with various

Single dose (O.Sml) vial with diluent: 575.00 IP ; VAXEM Rib Inj. Novartis VaccineslRenata

•.

Haemophilus influenzae type b (Hib) glycoconjugate vaccine is composed of bacterial capsular oligosaccharides conjugated to a carrier protein 'Cross Reacting Material 1 97 (CRM 197)" a nontoxic mutant of diphtheria toxin. Each single dose of 0.5ml contains: Active ingredient- l Omcg of capuslar oligosaccharide of H. influenzae type b conjugated to approximately 25mcg of CRM 1 97 protein.

Ind: Active immunisation against invasive disease caused by Haemophilus influenzae type b (Hib) in children from 2 months of age.

CII: Hypersensitivity to any component of the vaccine. Hypersensitivity reaction after previolls

tetanus, acellular pertussis and inactivated poliomyelitis vaccine, adsorbed and haemophilus available as powder and suspension for

infection, however, is not a contraindication to

subcutaneously.

Drug inter: See above, under ACT HIB vaccine.

and antiviral vaccine comprising diphtheria,

age: Adverse reactions (onset within 6 days of

illness. The presence of a minor non-febrile

or bleeding disorders, it is good clinical practice that the vaccine should be administered

.;. PENTAXIM Inj. Sanofi aventis Pentaxim: A pentavalent combined antibacterial

primary vaccination): Very common ( 1 0%):

Dosage & admin: Primary courses: Under 13 months of age: Three O.5ml doses, with an interval of at least 4 weeks between doses, the first dose to be given not earlier than two months of age, 13 months of age & over: A single O,5ml dose. Vaxem Hib is not recommended for healthy children aged more thaI) four years. Booster: Following completion of primary courses in which all three doses were administered before the age of 6 months, an additional (fourth) dose of Hib conjugate vaccine should be administered. The timing of the Hib conjugate booster dose should be in accordance with official recommendations. Children who were primed with Vaxem Hib may be boosted with Vaxem Hib or with another Hib conjugate vaccine. Similarly, Vaxem Hib may be used to boost children who were primed with other Hib conjugate vaccines. Administration: Vaxem Hib should be administered intramuscularly. Do not administer intravascularly. Patients with thrombocytopenia or bleeding disorders may be vaccinated by the subcutaneous route, Drug inter: In clinical studies, concomitant

But however, in patients with thrombocytopenia

DPT + POLIOMYELITIS + HAEMOPHILUS INFLUENZAE TYPE B (HIB) CONJUGATE VACCINE35

of age, for booster vaccination, one year after the primary vaccination during the second year of life. This vaccine does not protect against infectious disease due to other types of haemophilus influenzae or against meningitis caused by other micro-organisms.

CII: 1 . Progressive encephalopathies, with or without convulsions. 2. Major reaction(s) within 48 hours of a previous vaccine injection (such as fever greater than or equal to 40°C, persistent crying syndrome, febrile or afebrile convulsions, hypotonic hyporesponsive episodes), in such cases, vaccination should be completed with a vaccine which does not contain the pertussis vaccine. 3. Immediate hypersensitivity reactions following a previous injection (generalized unicaria, Quincke's oedema, anaphylactic shock). 4. Hypersensitivity reactions to active substances, excipients, neomycin, streptomycin or polymyxin B.

SfE; Precautions & warnings: Please see manufacturer's literature.

experiencing an immediate adverse reaction.

polioviruses (live attenuated), hepatitis S, or live

Dosage & admin: Primary vaccination: The course of vaccination is 3 injections at one or two month intervals from 2 months of age. Booster vaccination: 1 injection one year after the primary vaccination, generally between 16 and 18 months. Method of administration: This vaccine should be administered intramuscularly. The prefered injection site is the anterolateral surface of the thigh (middle third).

Vaxem Hib should be administered with caution

attenuated measles, mumps and rubella viruses.

Instructions for use & handling: Reconstitute

to subjects with thrombocytopenia or a bleeding

As with other vaccines it may be expected that in

the solution by injection of combined diphtheria,

disorder since bleeding may occur following an

patients receiving immunosuppressive therapy or

tetanus, acellular pertussis and poliomyelitis

intramuscular administration to these subjects. In

patients with immunodeficiency, an adequate

vaccine in the powder vial of haemophilus

these subjects the vaccine may be administered

immune response may not be achieved. Different

influenzae type b vaccine. Shake until complete

by deep subcutaneous injection. Tn the presence

injectable vaccines must not be mixed in the

dissolution of the powder. The whitish-turbid

of congenital or acquired immune deficiency,

same syringe and should be administered at

aspect of the suspension after reconstitution is

Vaxem Hib may be administered but a protective

different injection sites.

normal. The vaccine must be injected

immune response may not be elicited. Although a

O.Sml amp x I 's pack: 461 .9S MRP

immediactely after reconstitution.

administration of Rib vaccines. As with other vaccines, vaccination should be postponed in subjects suffering from acute severe febrile

vaccination.

vaccines containing the following antigens did

Precautions: Recipients of the vaccine should

not affect immune responses to these other

remain under observation, until they have been

antigens- diphtheria and tetanus toxoids, whole

seen to be in good health and not to be

cell or acellular pertussis components,

QIMP-15 (381) Storage: Store at 2°C to SoC (in a refrigerator). Do not freeze.

Nole: For further information, please consult

be used during pregnancy and lactation only when clearly needed.

manufacturer's literature. Single dose vial (0.5ml) with prefilled syringe: 2044.S3 MRP

HEPATITIS-A VIRUS VACCINE4? HEPATITIS-A VIRUS VACCINE: Injection

Hepatitis A virus vaccine is a purified sterile

suspension containing fonnaldehyde-inactivated hepatitis A virus adsorbed onto aluminium hydroxide; the viral antigen content is determined by an ELISA test.

Mode of action: 'Hepatitis A virus vaccine'

causes active immunisation against hepatitis A virus (HAY) infection.

Ind: Active immunisation against hepatitis A virus (HAY) infection in subjects at risk of exposure to HAY.

ell:

during pregnancy and lactation and lack of adequate animal reproduction studies, it should

'Hepatitis A virus vaccine' should not be

administered to subjects with known hypersensitivity to any component of the vaccine, or to subjects having shown signs of hypersensitivity after previous administration of 'Hepatitis A virus vaccine',

SfE: 'Hepatitis A virus vaccine' is well-tolerated.

Most events reported were mild and did not last for more than 24 hours. The most frequently reported was injection site soreness (less than

0.5% reported as severe) which resolved, besides, mild local redness and swelling with a frequency of about 4% of all vaccinations. The systemic adverse events reported are headache, malaise, vomiting, fever, nausea, and loss of appetite,

Dosage & admin: See below under individual presentation_

Instructions for use, handling & disposal of ' vaccine: The vaccine should be inspected

visually for any foreign particulate matter and/or variation of physical appearance prior to administration_ Before use of 'Hepatitis A virus vaccine', the viaVsyringe should be well shaken to obtain a slightly opaque white suspension. Discard the vaccine if the content appears otherwise. Drug inter: Since ' Hepatitis A virus vaccine' is an inactivated vaccine, its concomitant use with

other inactivated vaccines is unlikely to result in interference ·with the immune responses. Concomitant administration of typhoid, yellow fever, cholera (injectable) or tetanus does not interfere with 'Hepatitis A virus vaccine I immune response. Concomitant administration of immunoglo-bulins dose not impact the protective effect of the vaccine.

necessary, the products must be given with

HEPATITIS-B VACCINE65.9?

different syringes and needles and at different injection sites.

Storage: Vaccine should be stored at +2°C to

+S°c. Do not freeze, discard if vaccine has heen frozen.

.:. AVAXIM Inj. Sanofi-aventis

Avaxim, an inactivated hepatitis A virus vaccine:

antigens in 0.5ml ampoule; child dose contains

subjects with thrombocytopenia or a bleeding disorder since bleeding may occur following an i.m injection to these subjects. Finn pressure should be applied to the injection site (without rubbing) for at least 2 minutes. As with other vaccines, IHepatitis A virus vaccine' should not be given in a subject suffering from acute severe febrile illness. A minor infection, however, is not a contra indication for vaccination. In haemodialysis patients and in subjects with an impaired immune system, adequate anti-Hav antibody titre may not be obtained after a single dose of 'Hepatitis A virus vaccine' and such patients may therefore require administration of additional doses of vaccine. As with injectable vaccines, appropriate medical treatment and supervision should always be readily available in case of a rare anaphylactic event following the administration of the vaccine. 'Hepatitis A virus vaccine' can be given to HIV infected persons. It is not known whether 'Hepatitis A virus vaccine' will prevent hepatis A in such a case, who was infected by hepatitis A

virus and was

Avaxim, adult dose contains 160 units of viral SO units of viral antigens in 0.5ml ampoule.

Dosage & admin: Adults and adolescents from 16 years onwards- a single dose of 'Avaxim' 160 units (0.5ml dose) is used for primary immunisation. Children & adolescents from age between 1 to 15 years- a single dose of 'Avaxim' 80 units (0_5ml dose) is used for primary immunisation_ a booster dose is recommeded at any time between 6 and 12 months after the primary immunisation, in order to ensure long term protection_ 'Avaxim' is administered by i.m injection. The site of injection is the deltoid region in adults and older children, and antero-Iateral part of the thigh in young children_ The vaccine should not be administered in the gluteal region. The vaccine should not be administered subcutaneously or intradermally since administration by these routes may result in a less than optimal anti-HAY antibody response_ 'Avaxim' should under no circumstances be administered intravenously_ Avaxim SO amp x I 's pack: 753.35 MRP

Avaxim 1 60 amp x I ' s pack: 1 275.55 MRP

.:. HAVRIX Inj_ GlaxoSmithKline

in incubation period at the time of vaccination.

Havrix, an inactivated hepatitis A virus vaccine:

Pregnancy & lactation: Due to lack of adequate

purified sterile suspension for i.1n injection.

human data on use of 'Hepatitis A virus vaccine'

O.5ml vial Uunior): 800.00 IP

l .Oml vial (adult): 1 325.00 IP

resolved within 24 hours. vaccine' should be administered with caution to

720 ELISA units of viral antigens in 0.5ml vial.

Dosage & admin: Adults and adolescents from 16 years onwards- a single dose of 'Havrix 1440 adult' (Iml dose) is used for primary immunisation. Children & adolescents from age between 1 to 15 years- a single dose of 'Havrix 720 Junior' (O_Sml dose) is used for primary immunisation_ A booster dose is recommeded at any time between 6 and 12 months after the primary immunisation, in order to ensure long term protection_ Havrix is administered by i.m injection. The site of injection is the deltoid region in adults and older children, and antero-Iateral part of the thigh in young children_ The vaccine should not be administered in the gluteal region. The vaccine should not be administered subcutaneously or intradermally since administration by these routes may result in a less than optimal anti-HAV antibody response. Havrix should under no circumstances be administered intravenously_

vaccines or of immunoglobulins is considered

purified sterile suspension for i.m injection.

Precaution & warnings: 'Hepatitis A virus

viral antigens in 1m! vial; child dose contains

When concomitant administration of other

with a frequency varying between 0.8% and 1 2.8% of vaccinations, these are all mild &


Havrix, adult dose contains 1440 ELISA units of

HEPATITIS- B Vaccine: Injection_

Hepatitis-B vaccine (yeast derived), prepared by recombinant DNA technique.

Ind: I . Prevention of hepatitis B virus infection

(all known subtypes) by active immunization. 2.

Prevention of vertical transmission of Hepatitis B virus infection (should be administered in combination with Hepatitis B immunoglobulin). 3. Protection of transmi-ssion of Hepatitis-B virus infection after acute exposure to blood containing HBs Ag.

CII: Hypersensitivity to any component of the vaccine.

Precautions: i. Avoid injecting at the site of nerve. ii. Immediately drawout the needle

when serious pain or back flow of blood into the syringe occurs. Reinject at a different site.

SfE: i. Hypersensitivity. ii. Digestive system

nausea, diarrhoea, loss of appetite. iii.

psychoneurologic- headache. iv. others- fatigue, joint pain.

Dosage & Admin: See under individual praparation_

Vaccination for intants bom to HBs Ag+positive mothers: Infants born to HBs Ag positive mothers are at high risk of becoming chronic carriers of Hepatitis-B virus & of developing the chronic sequelae of Hepatitis-B virus infection_ Results of clinical studies have shown that administration of one O.Sml dose of Hepatitis B immune globulin at birth & three O_Sml (Smcg) doses of Hepatitis-B vaccine, the first dose given within one week after birth, 2nd dose at 1 month & 3rd dose at 6 months of age was 96% effective in preventing establishment of the chronic carrier state in infants born to HBs Ag & HBeAg positive mothers_ The first dose of Hepatitis-B vaccine may be

IMMUNOLOGICAL PRODUCTS & VACCINES given at birth at the same time as Hepatitis-B immune globulin, but should be administered in the opposite anterolateral thigh_ This procedure may be preferable to ensure absorption of the vaccine_ Testing for HBsAg & anti-HB, is recommended at 12-15 months to monitor the final success or failure of therapy_ If HBsAg is not detectable & anti-HBs is present, the child has been protected_

AClite exposlire to blood containing HBsAg: Hepatitis-B immune globulin 0_06ml/kg should be given as soon as possible after exposure & within 24 hours if possible_ Hepatitis-B vaccine LOml (10mcg) shonld be given Lm within 7 days of exposure & 2nd & 3rd doses given one & six months respectively after the first dose_ Site of injection: Preferably into the deltoid muscle in adults & the anterolateral aspect of thigh in infants & young children_ Time interval: a minimum of one month should seperate successive injections of vaccine_ Accelerated regimens (e_g 0, 1 and 2 months or 0, 2 and 4 months) may induce protective antibody earlier in a slightly larger proportion of vaccines. Storage: Store vials at 2-8'C. Storage above or below the recommended temperature may reduce potency. Do not freeze, since freezing destroys potency. Note: For additional information, please consult manufacturer's literature. .:. ENGERIX-B Inj_ GlaxoSmithKline Hepatitis-B vaccine (yeast derived), prepared by recombinant DNA technique. Each adult dose contains I ml (20mcg) and child dose contains O.Sml ( I0mcg) of Hepatitis-B surface antigen protien in vial & prefilied syringe: i.m injection. Ind; CII; SIE; Cautions: See above under hepatitis-B vaccine. Dosage & Admin: Adult- 2 doses of 1ml each of the vaccine should be administered soc or i.m on the outer site of upper arm at an interval of 1 month. A third dose of 1ml should be given 5 to 6 months after the first inoculation. For more rapid immunization the 3rd dose can be given 2 months after initial dose with a booster at 12 months. Children- under 10 years old, 3 doses of 0.5ml each should be injected in the same mannar (as adult). O.Sml in prefilied syringe: 400.00 MRP I ml in prefilied syringe: 600.00 MRP 1 0ml vial (multi-dose): 4500 . 00 MRP .:. EUVAX-B Inj. L.G ChemicallCity Overseas Hepatitis-B vaccine (yeast derived), prepared by recombinant DNA technique. Each adult dose contains Iml (20mcg) and child dose contains 0.5ml (10mcg) of Hepatitis B surface antigen protien per vial: i.m injection. Ind; CII; SIE; Cautions: See above under hepatitis-B vaccine. Dosage & Admin: Adult- 2 doses of Iml each of the vaccine should be administered s.c or i.m on the outer site of upper arm at an interval of 1 month. A third dose of 1ml should be given 5 to 6 months after the first

QIMP-lS (382) inoculation. For more rapid immunization the 3rd dose can be given 2 months after initial dose with a booster at 12 months. Children- under 10 years old, 3 doses of 0.5ml each should be injected in the same mannar (as adult). O.Sml vial (child): 230.00 TP I ml vial (adult): 340.00 TP .:. HEPAVAX-GENE Inj. Berna Biotechl Tajarat Hepatitis-B vaccine (yeast derived). prepared by recombinant DNA technique. Each adult dose contains 1 ml (20mcg) and child dose contains 0.5ml (10mcg) of Hepatitis B surface antigen protien per vial: Lm injection. Ind; CII; SIE; Cautions: See above under hepatitis-B vaccine. Dosage & Admin: Adult- 2 doses of Iml each of the vaccine should be administered s.c or Lm on the outer site of upper arm at an interval of 1 month. A third dose of 1 ml should be given 5 to 6 months after the first inoculation. For more rapid immunization the 3rd dose can be given 2 months after initial dose with a booster at 12 months. Children- under 10 years old, 3 doses of 0.5ml each should be injected in the same mannar (as adult). O.Sml vial x I D's pack: 1.0mi vial x I D's pack: 10ml vial (multi-dose) x I D's pack:

MEASLES VACCINE2 J .33 .:. MORVILVAX Inj. Chairon SpA Live attenuated measles vaccine (schwarz strain); freeze-dried powder in single dose vial with water for injection . Indo Prophylaxis (immunisation) against measles. ell: Pregnancy; infection (overt or incubating), malignant disease, active tuberculosis; allergy to hens eggs; hypog-ammaglobulinaemia; treatment with corti-costeroids; cytotoxic drugs, irradjation. SIE: Fever, parotits. Caution: Children with history of convulsions , parental history of epilepsy. Avoid administration within 3 weeks of other live vaccines or 12 weeks of transfusions or immunoglobulin injection. Dosage & admin: Adult: 0.5 ml by L m or s_ c injection Child: Under 1 year, not recommended; others same as adult. I dose vial with diluent: 53.94 MRP Preparation: May not be available; price could not be revised.

MENINGOCOCAL VACCINE35 MENINGOCOCAL VACCINE: Injection Meningococcal polysaccharide vaccince, prepared from Neisseria meningitidis (meningococus): injection. Ind: Active immunisation in adults and children over 1 8 months of age against meningococcal infection. This is indicated for areas of the world where the

risk of acquiring meningococcal infection is much higher. These areas include Bangladesh & other subcontinental countries & many of the intercontinental countries. Saudi Arabia specially requires vaccination of pilgrims to Mecca during the Haj annual pilgrimage; this may apply to others visting Saudi Arabia in the months leading up to August. Dosage & admin: See below under individual product. .:. MENCEVAX ACWY Inj. GlaxoSmithKline Meningococcal polysaccharide vaccince, prepared from Neisseria meningitidis (meningococcus) serogroup A, C, W I 3S and Y: injection. Dosage & admin: Adult and child aged over 18 months 0.5ml by deep sIc injection. 1 vial + diluent: 1140.00 MRP Note: For further information consult manufacturer's literature. .:. MENINGOCOCCAL (A+C) lnj. Sanofi aventis Meningococcal polysaccharide vaccince, prepared from Neisseria meningitidis (meningococcus) groups A and C: injection. Dosage & admin: Adult and child aged over 18 months 0.5ml by deep s.c or i.m injection_ 1 vial + diluent: 354.38 MRP Note: For further information consult manufacturer's literature.

MUMPS VACCINE" .33 .:. MUMPSVAX Inj. Morson Live mumps virus vaccine (Jeryl Lynn strain) single dose vial with syringe containing solvent. Ind: Mumps immunisation in adults and children over I year of age. CII; Cautions: See (same as ) Morbilvax. Dosage & admin: Adult: Inject total volume (0.5 ml) of reconstituted vaccine by s. c. route. Child: Under 1 year, not recomme-nded; over 1 year, same as adult. Preparation: may not be available.

MMR VACCINE2J.35.97 MMR Vaccine: Injection MMR is a combination vaccine of live measles, mumps, and rubella virus vaccine; available as O.Sml vial (single dose) injection for subcutaneous or intramuscular use. Ind: I . It is indicated for combined immunization against measles, mumps & rubella. As a general guide, the first dose of MMR vaccine is administered to children aged from 12 months. A second (booster) dose of MMR or monovalent measles vaccine is recommended before starting school at 3-6 years of age. Children presenting for their pre-school booster who have not received their first dose of MMR vaccine should be gi'len a dose of MMR vaccine then followed by a second dose 3 months later. 2. MMR vaccine can be used in place of measles vaccine for children & should be given ilTespective of previous measles, mumps or rubella infection. 3. To control outbreaks of measles and should be

QIMP-15 (383) offered to susceptible children within 3 days of exposure to infection.

CII: I. Children with untreated malignant disease or altered immunity, & those receiving immunosuppressive drugs or radiotherapy, or high-dose corticosteroids 2. Children who have received another live vaccine by injection within 3 weeks. 3. Children with allergies to neomycin or kanamycin. 4. Children with acute febrile illness. 5 . If given to women of childbearing age, pregnancy should be avoided for 3 months (as for rubella vaccine).

6. Should not be given within 3 months of an immunoglobulin injection. 7. Children with partial or totally impaired immune responsiveness, should not receive any live vaccine. 8. MMR vaccine is not suitable for prophylaxis following exposure to mumps or rubella since the antibody response to the mumps and rubella components is too slow for effective prophylaxis. AIR: Malaise, fever or a rash may occur following the fist dose of MMR vaccine, most commonly about a week after immunisation and lasting about 2 to 3 days, (paracetamol may be given for fever). Nausea, vonaiting, & diarrhoea may occasionally occur. Parotid swelling also reported, usually in the third week. rarely local allergic reactions, urticaria anaphylaxis & anaphylactoid reactions may occur. After a second dose of MMR vaccine, adverse reactions are considerably less common than after the first dose. Post- vaccination meningoencephalitis was also reported (rarely & with complete recovery). Precautions: I. Adequate treatment provisions including adrenaline injection should be available for immediate use as in anaphylactic reaction (if any). 2. Children with a personal or close fanaily history of convulsions should be given MMR vaccine, provided the parents understand that there may be a febrile response; doctors should seek specialist paediatric advice rather than withold vaccination; there is increasing evidence that MMR vaccine can be given safely even when the child has had an anaphylactic reaction to food containing egg. Dosage & admin: The dosage of vaccine is the same (O_Sml) for all age groups_ Inject the total volume of the single dose vial (O'sml) reconstituted vaccine deef subcutaneously or intramuscularly (do not inject intravenously),

preferably into the outer aspect of upper arm_ Reconstitute the powder of the vial with the diluent supplied_ Storage: Before reconstitution store MMR vaccine at 2_8°C & protect from light. .:. PRIORIX Inj_ GlaxoSmithKline Live measles, mumps, and rubella virus vaccine, 0.5ml vial (single dose): for deep s.c or i.m injection. 0.5ml vial (single dose) with diluents: 603.59 MRP .:. TRIMOVAX Inj_ Sanofi-aventis Live measles, mumps, and rubella virus vaccine, 0.5ml vial (single dose): for deep s.c or Lm injection.

0.5ml vial (single dose) with diluent x l O's pack: 3448. 10 MRP

PERTUSSIS VACCINE Vaccine preparations- see as mixed vaccine products under diphtheria vaccines (above).

POLIOMYELITIS VACCINE21 .33 •:. ORAL VIRELON Drop_ Behring A suspension of suitable live attenuated strains of poliomyelitis virus, type 1 , 2 & 3; available as single dose and 5 doses ampoules. Ind: Active immunisation against Poliomyelitis. CII: Diarrhoea; Hypogammaglobulina-emia; Febrile illness or any active infection is present. SIE: Paralysis (very rarely reported) . Dose: 3 doses course, each dose (2-3 drops) given orally at an interval of 6-8 weeks (see immun. schedule). 10 amps of 5 doses: 965.25 MRP Price: Could not be revised.

.:. POLl ORAL Drop Chairon SpA A suspension of suitable live attenuated strains of poliomyelitis virus, types I, 2 & 3 Ind: Active immunisation against poliomyelitis. CII; SIE: See above (oral virelon) Dose: 3 doses course. each dose (2-3 drops) given orally at an interval of 6-8 weeks (see immunisation schedule)_ 10 doses vial: 68.28 MRP Preparation: May not be available.

IMMUNOLOGICAL PRODUCTS & VACCINES Subjects vaccinated more than one year ago depending on the seriousness of the case give: First booster on day 0-0 Second booster on day 0-3 Third booster on day 0-7 c) Finally, in cases of very severe biting, on day 0-0, give additional treatment of 20 i.u per kg of human antirabies immunoglobulin; or 40 L u per kg of a purified antirabies serum of equine origin. Note: Dosage for children is the same as for adults . .:. VERORAB RABlES Vaccine Sanofi-aventis The Verorab is a purified Vera-rabies vaccine (PVRV) presented in freeze- dried form, as a single vaccinating dose of the inactivated vilUs. The vims is produced on VERO cell cultures. These are heteroploid cells, derived from a mon-key kidney cell culture (cercopithecus aethiops) and adapted for mass cultivation on microcarriers. The vaccine is reconsti-tuted with 0.5ml of solvent (sodium chloride solution) at the time of use. Dosage & Admin: Adults & children:

1. Preventive action or pre-exposure prophylaxis: 3 injections of O.Sml vial on 0-0, 0-7, 0-28. Booster- 1 year later 1 injection & then every . five years 1 injection if the risk persists (a variation of a few days is not important). 2. Post-exposure treatment or immunization: a) If the subject has not been vaccinated after being bitten by an animal with rabies or suspected rabies, S soc or Lm injections (each dose O.Sml) should be given on days 0-0, 0-3,

0-7, 0-14, 0-28.

RABIES VACCINE35.41 ANTI-RABIES Vaccine: Injection Anti-rabies vaccines are inactivated rabies vaccine. Ind: The vaccine is used for- I . pre exposure prophylaxis and 2.post exposure treatment of rabies. CII: I . Patients with fever or severe malnutrition. 2. acute, aggravating cardiac, renal or hepatic disorders. 3. hypersensitivity to eggs, chicks or chicken products. 4. pregnant mother. 5. history of convulsion within one year before inoculation. SIE: See above- common to vaccinations in general. Dosage & Admin: Adults & children: 1. Preventive action or pre-exposure prophylaxis: 2 doses of Iml injection each should be given s.c or i.m one month apart. Booster- 1 year later 1 injection (Iml). Subsequent boosters- every three years 1 injection (lml) if the risk persists. This preventative vaccination is recommended for those living in an endemic area. 2. Curative action or treatment of rabies after

b) If the subject has had preventive vaccination those vaccinated less than one year ago- give a booster on day: 0-0. Subjects vaccinated more than one year ago depending on the seriousness of the case give: First booster on day 0-0 Second booster on day 0-3 Third booster on day 0-7 c) Finally, in cases of very severe biting, on day 0-0, give additional treatment of 20 i.ulkg of human antirabies immun-oglobulin; or 40 i.u/kg of a purified antirabies serum of equine origin. Note: Dosage for children is the same as for adults. I vial + diluent: 540.00 MRP .:. RABIPUR Vaccine Chiron BehringlRenata Purified chick embryo cell rabies vaccine, I ml vial: injection Dosage & Admin: See above under Anti Rabies vaccine. Iml vial: 550.00 MRP

ROTAVIRUS VACCINE47

exposure:

a) If the subject has not been vaccinated after being bitten by an animal with rabies or suspected rabies, 6 subcutaneous injections should be given on days: 0-0, 0-3, 0-7, 0-14, D-30, 0-90. b) If the subject has had preventive vaccination those vaccinated less than one year ago- give a booster on day: 0-0.

.:. ROTARIX Oral Vaccine GlaxoSmithKline Rotavirus vaccine containing live attenuated human rotavirus RIX441 4 strain. Rotarix vaccine is presented as !tnl vial for oral administration. lnd: Rotarix is indicated for the prevention of gastro-enteritis caused by rotavims, G l and non G I serotypes (such as G2, G3, G4, G9).

QIMP-IS (384)

IMMUNOLOGICAL PRODUCTS & VACCINES CII: Rotarix should not be administered to subjects with know hypersensitivity after

previous administration of Rotm1x vaccine or to

any component of the vaccine. Rotarix should not

(DTPw), Diphtheria-tetanus-acellular pertussis vaccine (DTPa), Haemophilus influenzae type b

TUBERCULOSIS VACCINE2 198

vaccine (Hib). inactivated Polio vaccine (IPV),

Hepatitis B vaccine and Pneumococcal vaccine.

.:. BCG Inj_ ConnaughtJ Sanofi-aventis

be adminstered to subjects with any history of

Concomitant administration of Rotarix and oral

uncorrected congenital malformation of the

response to the polio antigens. Although

from the bacillus of Calmette

reduce the immune response to rotavirus vaccine

olders): injection.

chronic gastrointestinal disease including any

polio vaccine (OPV) does not affect the immune

gastrointestinal tract.

concomitant administration of OPV may slightly

reaction profile observed in the subjects receiving

there is currently no evidence that clinical

AIR: In controlled clinical studies, the adverse Rotarix was similar to the adverse reaction

protection against severe rotavirus gastroenteritis

No increase in the incidence or severity of these

Rotarix is unaffected when OPV is administered

However, some adverse reactions considered as

to drive and use machines- not applicable.

profile observed in subjects receiving placebo.

reactions was seen with the second dose. being at least possibly related to Rotarix

would be affected. The immune response to

two weeks apart from Rotarix. Effects on ability I ml vial (oral single dose): 1 3SS.00 MRP

vaccination were reported. Very common are irritability, loss of appetite; common are

diarrhoea, vomiting, flatulence, abdominal pain,

TETANUS VACCINE

regurgitation of food, fever, fatigue; uncommon

are- crying, sleep disorder, somnolence,

constipation rare; upper respiratory tract infection hoarseness, rhinorrhoea, dermatitis, rash, muscle

cramp; very rare- gastro-enteritis. In a large

safety trial, subjects vaccinated with Rotarix gave

evidence of no increased risk of intussusception

when compared with subjects receiving a

placebo.

Precautions: Vaccination should be preceded by a review of the medical history (specially with regard to previous vaccination and possible

occurence of undesirable events) and clinical examination. The administration of 'Rotarix'

should be postponed in subjects suffering from

acute severe febrile illness and suffering from

diarrhoea or vomiting. The presence of a minor

infection, however, is not a contra-indication for immunisation. Rotarix has not specifically been

studied in subjects with known primary and

secondary immunodeficiencies including HIV

positive infants. A protective immune response

may not be elicited in all vaccines. Rotarix does

not protect against gastro-enteritis due to other

pathogens than rotavirus. Rotarix is for oral use

only. Rotarix should under no circumstances be

injected.

Pregnancy & lactation: Rotarix is not intended for use in adults.

Dosage & admin: The vaccination course consists of two doses_ The first dose may be administered from the age of 6 weeks. There should be an interval of at least 4 weeks between the dosages_ The vaccination course should be completed by the age of 24 weeks. Lyophilised vaccine to be recostituted with a liquid diluent before oral administration_ After reconstitution, 1 dose (lml) contains- live attenuated human rotavirus RIX4414 strain not less than H)6 CCID50_ Repeat dosing is not indicated if an infant should spit out, regurgitate or vomit during or after the administration of the vaccine_ The vaccination course should be completed as recommended above_ There are no restrictions on the infant's consumption of food or liquid, including breast-milk, either before or after vaccination_ Drug inter: Rotarix can be given concomitantly with any of the following administered either as

monovalent or as combination vaccines:

Diphtheria-tetanus-whole cell pertussis vaccine

Vaccine preparations- See as mixed vaccine

products (DPT) under diphtheria vaccines (above).

preparation of live bacteria of a strain derived

& Guerin; I ml vial

(20 doses for neonates or 10 doses for the

Ind: Active immunisation against tuberculosis. SIE: Fever and local pain with formation of a papular rash at the site of injection .

Dose: O_lml (infants under 3 months 0.05ml) by intradermal injection_ I ml vial: 176.00 MRP

Preparation: May not be available; price could

not be revised.

TYPHOID FEVER VACCINE47.98 .:. TYPHERIX Inj. GlaxoSmithKIine

Typherix is a Vi polysaccharide typhoid vaccine,

extracted from Salmonella typhi Ty2 strain. Each

TETANUS TOXOID21.33 TETANUS VACCINE: Injection

Tetanus vaccine prepared from purified tetanus

formol toxoid, adsorbed on to a mineral carrier (usually aluminium hydroxide gel); O.Sml

ampOUle: injection.

Ind: Active immunisation against tetanus.

ell: Concurrent acute

Bacillus Calmette-Guelin vaccine- a freeze dried

infections disease except

in a tetanus prone wound.

Dosage & admin: 0_5ml by Lm or deep soc injection followed after 4 weeks by a second dose and after a further 4 weeks by a third dose (see immunisation schedule)_ Reinforcing doses: 0_5ml at 18 months to 2 years of age; 2nd booster, at 5-6 years (school going age); 3rd booster at 10 years of age_ In the event of injuries which may give rise to tetanus, administer a single dose of 0.5ml unless a booster has been given in the preceding year. All by deep soc or Lm injection_ .:. TETAVAX Inj_ Sanofi-aventis

Purified tetanus toxoid 40 i.uIO.Sml ampOUle:

injection

20 amps pack: 2 12 6 . 2 1 MRP

TETANUS ANTITOXIN (ATS)21.72 .:. TETANUS ANTITOXIN (ATS) Inj_ Medimpex

O.Sml dose of vaccine contains 2Smcg of the cell

surface Vi polysaccharide of Salmonella typhi : solution for i.m injection.

Ind: Active immunisation against typhoid fever

for adults and children older than two years of age.

CII: Known hypersensitivity to any component

of the vaccine or subjects having shown signs of

hypersensitivity after previous administration.

AIR: In clinical studies, in the majority of instances, redness, pain and swelling were

usually reported only during the first 48 hours

following immunisation; most common reaction is pain, not exceeding 7%. Systemic reactions

were also transient, and the reported symptoms

are fever, headache, general aches, malaise, nausea and itching, not exceeding 9%.

Anaphylaxis, allergic reactions, including

anaphylactoid reactions and urticaria have been

reported very rarely with Typherix.

Precautions & warnings: As with other

vaccines, administration of Typherix should be

postponed in subjects suffering from acute severe febrile illness. Typherix should under no

circumstances be administered intravenously.

The vaccine protects against typhoid fever

caused by Salmonella typhi. Protection is not conferred against paratyphoid fever or illness

caused by non-invasive Salmonellae.

Pregnancy

& lactation: Adequate data on use in

human during pregnancy or lactation and

adequate animal reproduction studies are not

available.

SIE: Hypersensitivity.

Dosage & Admin: O.5ml single dose vaccine for both children and adult by intramuscular injection_ Shelf-life: 24 months when stored at + 2'C to + 8'C. Storage: Before reconstitution store the vaccine at + 2'C to +8'C; do not freeze,

Dose: See treatment of tetanus in the medicine section_

Salmonella typhi Vi purified capsular

Preparation: May not be available; price could

ingedients) per single dose pre-filled syringe

Tetanus antitoxin (anti-tetanus serum) 10,000 i.u/vial: injection.

Ind: Passive immunisation against (& treatment

of) tetanus.

CII: History of hypersensitivity to tetanus

antitoxin.

Caution: Skin test for hypersensitivity.

Smi vial: 1 3S.00 MRP

not be revised.

O.Sml vial: 407.0S MRP

.:. TYPIDM VI Inj_ ConnaughtJSanofi-aventis

polysaccharide 0.02Smg (with other preservative with water as diluent qs O.Sml: i.m (or s.c)

QIMP-15 (385) injection

'Ind: Prevention of typhoid fever in adults and children over 5 years of age, specially travellers. to endemic areas, immigrants, health care professionals, and military personnel. Between 2 and 5 years of age, the decision to vaccinate should be based on careful evaluation of the risk of typhoid fever in the light of the epidemiological situation. CII: Hypersensitivity to a constituent of the vaccine. Children under 5 years- the antibody response as yet undocum�nted, vaccination is usually not advised; and as because typhoid fever is rare in infants, vaccination of children under 2 years of age is also not recommended. SIE: Mild pain at the site of injection; infrequent erythema or induration may also occur at the injection site. Mild fever is observed in 1 -5% of cases. Precantion & warnings: This vaccine protects against infection by Salmonella typhi but does not protect against Salmonella paratyphi A or B. Immunization should be postponed in subjects with faver or acute infection. Pregnancy and lactation- the risk during pregnancy is not yet known; expected benefits must be carefully evaluated in the light of the epidemiological situation. Preservation- to be kept refrigerated (between +2?C and + 8?C). Dosage & admin: A single injection ensures protection, a second injection is not justified, (but to a limited number of subjects, a second injection has been given). Protection lasts for at least 3 years. The preferred route of administration is intramuscular although it may also be given subcutaneously. I syringe of 1 dose (0.5ml) vaccine: 406.65 MRP

IMMUNOGLOBULIN PREPNS. 1 .21,123 Immunoglobulins are protein molecules that exhibit antibody activity. They are glycoproteins composed of polypeptides (82-96%) and carbohydrates (4- 18%). The polypeptide components possess almost all the biological properties associated with the antibody activity. Antibodies are multifunctional molecules. Above all, they bind antigens and initiate a range of secondary phenomena such as complement activation which is independent of their antigen specificity. There are 5 classes of immunoglobulins- IgG, IgA, IgM, IgO, IgE. Among these, IgG comprises about 85% of total serum immunoglobulins. IgG immunoglobulins are formed during the course of the humoral immune response from B lymphocytes and plasma cells, and are distributed in the extracellular fluid. They are the only antibody class able to cross the placenta. Immunoglobulins are prepared from two origins: I. Animal origin (known as antisera), were frequently associated with hypersensitivity which led to their virtual abundonment. 2. Human immunoglobulins- (which have replaced animal immunoglobulins). Again human immunoglobulins are of 2 types- i.

Normal immunoglobulin & ii. Specific immunoglobulin.

Human Normal Immunoglobulins (HNIG) -

These are the gamma globulins, prepared from pools of at least LOOO donations of human plasma; and contains antibody to measles, mumps, hepatitis A, rubella, varicella and other viruses currently prevalent in the general population. Human Specific Immunoglobulins (HSIG) These are the gamma globulins, that are prepared as antibodies against different specific infections, viz. Hepatitis-B immunoglobulin (HBIG), Rabies immunoglObulin, Tetanus immunoglobulin (HTIG), Varicella zoster immunoglobulin (VZIG)

Mecbanisms of action of immunoglobulins: Immunoglobulins are the main players of humoral immune activity. They neutralise toxins or viruses, activate complement and stimulate phagocytosis by opsonisation. In functional terms, immunoglobulins play the role of mediators between the specific recognition and binding of antigens and the activation of unspecific effector mechanisms in the organism. Antigen-specific binding occurs via the variable part of the Fab region of immunoglobulin structure. Immunoglobulin as a bivalent antibody- it has two antibody binding sites allows a three-dimensional cross-linking of antigens. They play an important role in the counter regulation of autoantibody formation by lymphocytes.

Human Normal Immunoglobulin 21,33 HUMAN NORMAL IMMUNOGLOBULIN: Injection

IMMUNOLOGICAL PRODUCTS & VACCINES prophylaxis (3-5 months or more) & to control outbreaks, adult 500mg & child under 10 years 250mg by deep Lm injection. Measles prophylaxis- child under 1 year 250mg, 1-2 years 500mg, 3 years and over 750mg by deep i.m injection. Rubella in pregnancy, & prevention of clinical attack- 750mg by deep Lm injection. Normal immunoglobulin for i.v use: Normal human immunoglobulin preparations for Lv administration are available for replacement therapy as in hypogammaglobulinaemia and other immune deficiency states, following burns etc. The usual dose is 0_2-0.8mllkg body weight, to be repeated every 4-8 weeks. The administration must be performed at a high dilution (at least 1:20) & very slowly (15 drops/min.) while the patient is kept under close clinical supervision. Note: For further information- consult product literature. .:. HUMAGLOBIN Inj. Human Co./City Overseas Freeze-dried normal human immune globulin preparation, 2.5gm vial with 50ml solvent & 5gm vial with 100ml solvent: for i.v injection or infusion Ind; CII; SIE; Cautions: See above under the text of normal human immunoglobulin Dose & admin: 0.2-0.8mllkg body weight, by i.v administration, to be repeated every 4-8 weeks. It is advisable to administer in Lv infusion. The administration must be performed at a high dilution (at least 1:20) & very slowly (15 drops/min.) while the patient is kept under close clinical supervision. Note: For further information-consult product literature. 2.5gm vial with 5ciml solvent: 18500.00 TP 5gm vial with 1 00mi solvent: 36500.00 TP

Ind: I . Protection of susceptible contacts against hepatitis-A virus, measles, mumps, varicella & to a lesser extent rubella in pregnant woman. 2. Treatment of hypogammaglobulinaemia and other immune deficiency states, following bums.

.:. PENTAGLOBIN Inj. Biotest Pharma! UniHealth I ml solution contains- human plasma protein 50mg, of which immunoglobulin at least 95%, IgM 6mg, IgA 6mg, IgG 38mg.

CII: Known case of hypersensitivity to any component of normal human immunoglobulins. SIE: Hypersensitivity reactions.

Ind: Adjuvant therapy of severe bacterial infections additional to antibiotic therapy. Immunoglobulin substitution in immunoco mpromised patients.

Precautions: Live virus vaccine should not be given untill 3 months after a dose of normal immunoglobulin injection. If a live virus vaccine has been given, normal immunoglobulin inj. should not be gi ven for at least 2 weeks, except in special circumstances. For example, the concomi-tant admin. of measles vaccine with a suitable immunoglobulin is recommended for children with certain neurological disorders. Rubella vaccine may be administered in the post-partum period with anti-O(Rh) immunoglobulin injection. Monitor for signs of anaphylactoid reactions during injection. Dosage & admin: Normal immunoglo-bulin for Lm use: Hepatitis-A prophylaxis- travel prophylaxis for short period (2 months or less abroad) adult 250mg & child under 10 years 125mg by deep Lm injection; for longer travel

CIE; SIE; Cautions: See above under normal human immunoglobulin. Dose & Admin: Neonates, infants, children and adults- 5mllkg body weight daily on 3 consecutive days. Further infusions may be required depending on the clinical course. Immunoglobulin SUbstitution in immunocompro-mised patients- 3-5mllkg body weight, repetition at weekly intervals if necessary. Pentaglobin should be infused Lv at the following rates- in neonates and infants, 1.7mllkglhour by infusion pump; in children and adults, 0.4mllkglhour or alternatively, first 100ml at 0.4mllkgl hour then 0_2mllkgl hour continuously until 15mllkg is reached within 72 hours. IOml ampoule: 40 1 9 . 1 8 MRP


Human Specific Immunoglobulin HEPATITIS-B IMMUNE GLOBULIN 1 16 .:. HEPABIG Inj. Green Cross Corp.ffajarat Hepabig injection is a sterile solution containing hepatitis·B immune globulin (HBIG) which is prepared by Cohn fractionation from plasma of human individuals with high titres of antibody to hepatitis-B surface antigen (anti·HEs) and whose plasma does not show serologic evidence of hepatitis·B surface antigen (HBsAg). Also, donors are always checked up to exclude HIV and HCV infection before preparation of Hepabig. Hepabig injection contains· the specific antibody titre against the HBsAg- Hepatitis·B immune globulin 200 i.u/ml. Pharmacological action: Hepatitis·B immune globulin is used to provide passive immunity to hepatitis-B infection in the prophylactic treatment of individuals exposed to hepatitis·B virus of HBsAg positive materials. Antibodies specific to HBsAg (anti·HBs), which are present in Hepabig combine with HBsAg and neutralize the hepatitis·B virus, so that its infective or pathogenic properties are inhibited. Ind: I . Prophylaxis in neonates born to HBsAg positive mothers. 2. Post·exposure prophylaxis following percutaneous exposure to (e.g needlestick), direct mucous membrane contact with (e.g oral, ophthalmic), or ingestion (e.g pipetting accident) of material containing hepatitis·B virus or an HBsAg positive sourece of known identity. 3. Post·exposure prophylaxis following sexual or intimate contacts to an HBsAg positive individual. CII: Hepabig should not be administered to HBsAg positive individuals. But. no adverse reactions have been seen in individuals with pre existing hepatitis-B surface antigen although data regarding this occurrence are limited. AIR: Adverse reactions are infrequent, mild, and transient following administration of hepatitis-B immune globulin (HBIG). Local pain and tenderness at the injection site, urticaria and angioedema may occur. Precautions: Should not be administered intravenously. Should be given with caution to patients with a history of prior systemic allergic reaction following the administration of human immune globulin preparation. Should be given with caution to patients with Ig A deficiency syndrome, since these individuals may have serum antibodies to Ig A and anaphylaxis could result from fOllowing administration of blood products containing IgA. Following the administration of Hepabig, the application of live virus vaccine should be avoided for a period of 3 months because the antibody content of Hepabig may interfere with the immune response to the vaccination. Dosage & admin: Hepabig should only be administered by intramuscular injection. Following exposure to hepatitis-B virus (HEV), should be administered within 7 days (preferably within 48 hours) and, if necessary, repeat the same or increased quantity of dose.

QIMP·15 (386) The recommended dose for adult is 1,000 to 2,000 LU. In prophylaxis in neonates born to HBsAg positive mothers, should be injected within 5 days after birth (preferably within 48 hours) and repeated after fifteen days or 2/3 months after the first administration. The recommended initial dose is 100 to 200 LU (0.5 to 1ml) and booster dose is 32 to 48 LU per kg of body weight. Although post·exposure prophylaxis with hepatitis-B immune globulin (HBIG) alone was previously recommended for neonates born to HBsAg positive women, combined passive imumunization with HEIG and active immunization with hepatitis·B virus vaccine is currently recommended in these neonates. 0.5ml vial x I D's pack: I ml vial x 1 0's pack:

HUMAN ANTI-TETANUS IMMUNOGLOBULIN21.99.116.1 19 HUMAN ANTI·TETANUS IMMUNOGLOBULIN: LM Injection Human anti·tetanus immunoglobulin (TIG) 250 i.u/vial or syrine: Lm injection. Human anti-tetanus immunoglobulin is a liquid or lyophilized concentrate for intramuscular administration prepared from pooled human plasma of donors who have been immunized against tetanus and who have received a booster injection of tetanus vaccine prior to donation. Human tetanus immunoglobulin (TIG) is available in vials, ampoules or preloaded syringe for instant administration. Ind: Passive immunisation againsnetanus in non-vaccinated individual or treatment for declared tetanus. Sustained wounds possibly contaminated with tetanus bacilli. In all cases of passive immunization, tetanus vaccine (adsorbed) should be administered as soon as practicable. S/E: Slight local reactions like inflammation and tenderness may occur. Dosage & admin: Prophylaxis: in case of injury, thorough debridement and cleansing of the wound should be performed. Prompt Lm administration of 250 Lu.(lrnl) of TIG is usually adequate. (Child· 4 unitslkg body wt). In severe multiple injuries or of a highly potential tetanus infectivity the dose should be doubled. Passive immunization with immunoglobulin should be accompanied by simultaneous active immunization with adsorbed tetanus vaccine with seperate syringe & into saperate site. TIG usually provides a protective level of tetanus antitoxin over 0.01 i.u per ml serum for a period of 4 wks. Treatment: TIG could be used for the treatment of declared tetanus in conjunction with other therapeutic measures. The doses would range between 3,000 Lu. and 6,000 i.u. .:. TETABULIN SID 250 IV Inj. BaxterlUltra Pharma Human anti·tetanus immunoglobulin (TIG) 250 I. U in preloaded syringe for instant administration: i.m injection.

Dosage & admin: See above under the text. 250 l.U preloaded syringe: 467.00 MRP Preparation: May not be available now.

HUMAN ANTI-D IMMUNOGLOBULIN21,119 HUMAN ANTI·D IMMUNOGLOBULIN: Injection. Anti·O immunoglobulin is produced from the plasma of selected healthy donors with a high content of Rho(O) antibodies. Glycine and merthiolate are added as stabilizer and preservative. Indications: I. Rh·negative mother (not previously sensitized to the RhoO factor) after delivery of a Rh· positive child. 2.All nonsensibilized Rh·negative women after spontaneous or induced abortions, amniocentesis and transplacental haemorrhage. 3. Prophylaxis of erythroblastosis foetalis of every type. Anti·O (Rho) immunoglobulin is recommended for every first deliveries and all subsequent deliveries (also miscarriage) where Rho(O) sensitization may be expected. Contraindications: ANTI·O(Rho) Inununoglobulin must not be administered to· i . Rho(O) positive patients, ii. Rho(O) positive neonates, iii. mother previously sensitized to Rho(O) positive factor, & iv. known sensitivity to human protein. Precautions & warnings: For intramuscular use only; do not give intravenously. S/E: Generally well tolerated, on rare occasions anaphylactoid reactions may occur in a patient, or hypogammaglobulinaemic patients with antibodies to IgA, also ill patients who have shown an atypical reaction to blood or blood products. Dosage & admin: See below under individual product. Note: For further information- see manufacturer's literature. .:. PARTOBULIN SDF Inj. BaxterlUltra Pharma Anti·O immunoglobulin 1250 i.u (250mcg) in Iml single dose prefilled syring: i.m injection. Dosage & admin: One dose 1250 i.u (250mcg) should be given Lm immediately or as soon as possible after delivary, or abortion of a Rh positive child, preferably within 48 hours, but not later than 72 hours post partum. Following any potentially sensitising episode (e.g stillbirth, amniocentesis) up to 20 weeks of gestation 650 i.u (125mcg) per episode (after 20 weeks of gestation, 1250 i.u) immediately or within 72 hours. For antenatal prophylaxis 1250 i.u (250mcg) should be given in week 28 and also week 34 of pregnancy. The injection must only be given deep intramuscularly. Warning: Do not inject intravenously ! ! Storage: Partobulin SOF should be stored between +2'C and +8'C. The product should be brought to room or body temperature before use. I m! single dose prefilled syringe: 2497.00 MRP Preparation: May not be available now.

QlMP.15 (387) I.n�

ANAESTHETICS & MUSCLE RELAXANTS 1. 2.

General anaesthetics Local anaesthetics

GENERAL ANAESTHETICS2 1 1.1 1.2 1.3 1.4 1.5

Intravenous anaesthetics Inhalational anaesthetics Antimuscarinic drugs Sedative & analgesic peri·operative drugs Muscle relaxants used in general anaesthesia 1.6 Anticholinesterases used in anaesthesia a) Anticholinesterases used in general anaesthesia b) Reversal of the centrally sedative effects of benzodiazepines used in general anesthesia 1.7 Misc. preparations: preparation for cardiopulmonary bypass & open-heart surgery

Intravenous Anaesthetics ETOMIDATE 13] ETOMIDATE: I.V Injection. Etomidate, a hypnotic drug without analgesic ' activity, used for the induction of general anesthesia. [t is available as etomidate BP 20mg in l Oml ampoule with propylene glycol 35% vlv, for intravenous (i.v) injection. Mode of action: Etomidate i.v injection produces hypnosis characterized by a rapid onset of action, usually within one minute. Duration of hypnosis is dose dependent but relatively brief, usually 3 to 5 minutes when an average dose of O.3mglkg is employed. Ind: Etomidate is indicated for the induction of general anesthesia. When considering use of etomidate, the usefulness of its hemodynamic properties should be weighed against the high frequency of transient skeletal muscle movements. Etomidate is also indicated for the supplementation of subpotent anesthetic agents, such as nitrous oxide in oxygen, during maintenance of anesthesia for short operative procedures such as dilation and curettage or cervical conization. ell: Etomidate is contraindicated in patients who have shown hypersensitivity to it. AlE: The most frequent adverse reactions associated with use of i. v etomidate are transient venous pain on injection and transient skeletal muscle movements, including myoclonus.

ANAESTHETICS & MUSCLE RELAXANTS FKif

Skeletal muscle movements appear to be more frequent in patients who also manifest venous pain on injection. Respiratory system: Hyperventilation, hypoventilation, apnea of short duration (5 to 90 seconds with spontaneous recovery); laryngospasm, hiccup and snoring suggestive of partial upper airway obstruction have been observed in some patients. These conditions were managed by conventional counter measures. Circulatory system: Hypertension, hypotension, tachycardia, bradycardia and other arrhythmias have occasionally been observed during induction and maintenance of anesthesia, One case of severe hypotension and tachycardia, judged to be anaphylactoid in character, has been reported. Elderly patients, particularly those with hypertension, may be at increased risk for the development of cardiac depression following etomidate administration. Therefore, these patients may require lower doses of etomidate than younger patients. Gastrointestinal systenl: Postoperative nausea andlor vomiting following induction of anesthesia with etomidate is probably no more frequent than the general incidence. When etomidate was used for both induction and maintenance of anesthesia in short procedures such as dilation and curettage, or when insufficient analgesia was provided, the incidence of postoperati ve nausea andlor vomiting was higher than that noted in control patients who received thiopental. Precautions & warnings: Etomidate is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. As elderly patients are more likely to have decreased renal function, in these cases care should be taken and it may be useful to monitor renal function. Plasma cortisol levels: Induction doses of etomidate have been associated with reduction in plasma cortisol and aldosterone concentrations. These have not been associated with chang'es in vital signs or evidence of increased mortality; however, where concern exists for patients undergoing severe stress, exogenous replacement should be considered. Intravenous etomidate should be administered only by persons trained in the administration of general anesthetics and in the management of complication encountered during the conduct of general anesthesia. Because of the hazards of prolonged suppression of endogenous cortisol and aldosterone production, this formulation is not intended for administration by prolonged infusion. Pregnancy & lactation: Etomidate should be used during pregn�ncy only if the potential benefit justifies the potential risks to the fetus. Labor & delivery: There are insufficient data to support use of i.v etomidate in obstetrics, including caesarean section deliveries. Therefore, such use· is not recommended. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when etomidate is administered to a nursing mother.

Dosage & admin: Etomidate injection is

intended for administration only by the i.v route. The dose for induction of anesthesia in adult patients and in pediatric patients above the age of 10 years will vary between 0.2 and 0.6mgikg of body weight, and it must be individualized in each case. The usual dose for induction in these patients is 0.3mgikg, injected over a period of 30 to 60 seconds. There are inadequate data to make dosage recommendations for induction of anesthesia in patients below the age of 10 years; therefore, such use is not recommended. Geriatric patients may require reduced doses of etomidate. Smaller increments of i. v etomidate may be administered to adult patients during short operative procedures to supplement subpotent anesthetic agents, such as nitrous oxide. The dosage employed under these circumstances, although usually smaller than the original induction dose, must be individualized. There are insufficient data to support this use of etomidate for longer adult procedures or for any procedures in pediatric patients; therefore, such use is not recommended. The use of i.v fentanyl and other neuroactive drugs employed during the conduct of anesthesia may alter the etomidate dosage requirements. Etomidate hypnosis does not significantly alter the usual dosage requirements of neuromuscular blocking agents employed for endotracheal intubation or other purposes shortly after induction of anesthesia. Pediatric lise: There are iriadequate data to make dosage recommendations for induction of anesthesia in patients below the age of 10 years; therefore, such use is not recommended. Overdosage: Overdosage may occur from too rapid or repeated injections. Too rapid injection may be followed by a fall in blood pressure. No adverse cardiovascular or respiratory effects attributable to etomidate overdose have been reported. In the event of suspected or apparent overdosage, the drug should be discontinued, a patent airway established (intubate, if necessary) or maintained and oxygen administered with assisted ventilation, if necessary. .:. ETOMID Inj. Popular Etomidate BP 20mg in 1 0mi ampoule with propylene glycol 35% vlv, for intravenous (i.v) injection. 10mi (20mg) amp x 1 0's pack: 750.00 MRP

KETAMINE21.58 KETAMINE Hel: Injection Ind: It is a general anaesthetic with short onset of action, and applied for operations of short duration & in case of instrumental or painful diagnostic interventions. Also used for induction of anaesthesia prior to the admin. of .Lv anaesthetics. It potentiates the effect of inhalation anaesthetics of low potency (e,g N2 0). ell: Eclampsia, hypertension S/E: Elevated blood pressure, tachycardia. Hallucination, psychomotor agitation, mental confusion. It is incompatible with soluble barbiturates. Post-anaesthetic restlessness can

ANAESTHETICS & MUSCLE RELAXANTS usually be prevented with droperidol (0.1 mg/ kg i.m). Cautions: Resp. deppression may occur with overdose or very rapid rate of admn., in Which case supportive ventilation should be employed. It should be injected slowly (over a period of l onger than 60 seconds. Dosage & admin: Initial i.v dose varies between 1-4.5mglkg. The average dose, 2mglkg resulting in anaesthesia of 5-10 min. duration. The initial i.m dose varies between 6.5-13 mglkg. The average dose,10 mglkg brings anaesthesia of about 12-25 min. duration. Anaesthesia can be maintained by the initial or by the half of the initial doses.

:. CALYPSOL Inj. Gedeon Richter/City Overseas Ketamine hydrochloride SOmg/ml; 1 0mi vial: injection IOml (SOOmg) vial x l 's pack: 1 00.00 TP .:. G-KETAMINE Inj. Gonoshastha Ketamine hydrochloride SOmg/ml; I Oml vial: injection 1 0ml vial x l 's pack: 1 0 1 . 14 MRP .:. KETALAR Inj. Popular Ketamine hydrochloride SOmg/ml; I Oml vial: injection I Oml vial x I 's pack: I I S.OO MRP •

• :. KETAMINE-ROTEX Inj. Rotex Medical City Overseas Ketamine hydrochloride SOmg/ml; 1 0mi vial: injection .. 1 0ml (SOOmg) vial x I pack: 7S.00 TP .:. PENTYL Inj. ACI Ketamine hydrochloride SOmg/ml; 1 0mi vial: injection 1 0ml vial x I 's pack: l i S .00 IP

PROPOFOL95 PROPOFOL: Injection Ind: Induction & maintenance of general anaesthesia; sedation of ventilated patients receiving intensive care, for upto 3 days. Propofol is associated with rapid recovery without hangover effect. CII: If history of propofol allergy. S/E: Occasional reports of convulsions, anaphylaxis, & delayed recovery from anaesthesia; bradycardia, occasionally profound. There is sometimes pain on Lv injection. Cautions: Monitor blood lipid conc. in patients at risk of fat overload. If profound bradycardia develops, i.v administration of an antimuscarini� .. may be necessary to prevent this bradycardia. , Dosage & admin: Induction, by i.v injection, 2"2.5mglkg (less in elderly) at a rate of 2040mg every 10 seconds; Child over 3 yrs. 25mglkg adjusted as necessary. Maintenane, by i. v infusion, 4-12mglkglhour; Child, over 3 yrs. 9-15 mglkglhour. Sedation during intensive care (with assisted ventilation), by i.v infusion, 1-4 mglkglhour for upto 3 days. Child, not recommended. .:. FRESOFOL Inj. Fresenius Kabi/Hyeimpex Propofol 10mg/ml ; 20m I ampoule & SOml bottle:

QIMP-15 (388)

injection. 20mI amp x S's pack: 17S8.00 MRP SOml bot x I 's pack: 779.00 MRP Price: Could not be revised.

instillation. SOOmg vial x I 's pack: 60.00 MRP I gm vial x I 's pack: 100.00 MRP .:. TPS 1 Inj. Popular Thiopental sodium USP I gm/vial (powder for reconstitution): i.v injection or rectal instillation. I gm vial x I 's pack: 1 00.00 MRP

.:. POFOL LV Inj. Popular Propofol 1 0mg/ml; 20ml ampoule: i.v injection. 20ml amp x I 's pack: 200.00 MRP .:. RECOFOL Inj. Bayer Schering OylTajarat Propofol 10mg/ml; 20ml ampOUle: injection. 20ml amp x I 's pack: SOml vial x I 's pack:

.:. TPS 500 Inj. Popular Thiopental sodium USP SOOmglvial (powder for reconstitution): i.v injection or rectal instillation. SOOmg vial x I 's pack: 69.S9 MRP

THIOPENTONE SODIUM2 1 ,33

Inhalational Anaesthetics

THIOPENTONE SODIUM: I.V Injection or rectal instillation . Thiopentone sodium is a barbiturate drug without analgesic property. It is widely used as an intravenous anaesthetic. Ind: Induction of general anaesthesia; anaesthesia of short duration; it has no analgesic properties but induction is generally smooth & rapid & potent in action. CII: Porphyria S/E; Cautions: Owing to its narrow therapeutic margin, overdosage with cardiorespiratory depression may occur. Repeated doses have a cumulative effect. Sedative effects may persist for 24 hours. The reconstituted solution is highly alkaline and therefore irritant on misplaced injection outside the vein; arterial injection is particularly dangerous. Reduce induction dose in severe liver desease. interactions: Appendix (anaesthetics) Dosage & admin: By i.v injection, in fit premedicated adults, initially lOO-150mg (46ml of 2.5% solution) over 10-15 seconds, followed by further quantity if necessary according to response after 30-60 seconds; or up to 4mglkg:

DIETHYL ETHER21.33

Children: Induction, 2-7mglkg. .:. ANESTHO Inj. Incepta Thiopental sodium USP SOOmg & I gm/vial (powder for reconstitution): i.v injection or rectal instillation. SOOmg vial x I 's pack: 69.S9 MRP I gm vial x I 's pack: 1 00.00 MRP .:. G-THIOPENTAL Inj. Gonoshasthaya Thiopental sodium USP SOOmg & I gm/vial (powder for reconstitution): i.v injection or rectal instillation. 500mg vial x I 's pack: 60.00 MRP I gm vial x I 's pack: 1 00.00 MRP .:. THIOPEN Inj. ACI Thiopental sodium USP SOOmg & I gm/vial (powder for reconstitution): i.v injection or rectal instillation. SOOmg vial x I 's pack: 69.S9 IP I gm vial x I 's pack: 1 00.00 IP .:. THIOPENTONE-ROTEX fnj. Rotex MedicaiCity Overseas Thiopental sodium USP SOOmg & I gm/vial (powder for reconstitution): i.v injection or rectal instillation. SOOmg vial x I 's pack: 80.00 TP I gm vial x I 's pack: 1 1 0.00 TP .:. THIOTON Inj. Techno Drugs Thiopental sodium USP SOOmg & I gm/vial (powder for reconstitution): i.v injection or rectal

.:. ETHER ANAESTHETIC J.T Beker Diethyl ether, an inhalation anaesthetic. Ind: Used in general anaesthesia (but now is less popular due to increased risk of use) S/E: High incidence of nausea and vomiting Caution: Ether vapour forms inflammable and explosive mixtures with oxygen; both induction and recovery from anaesthesia are slow. Dosage & admin: From an open mark or a suitable vaporiser. Induction upto 20%, maintenance 3-10%. 946ml bot: Preparation: May not be available .

HALOTHANE2 1 ,9S, 1 10 HALOTHANE: Inhalation anaesthetic Halothane is a most widely used inhalation anaesthetic. Ind: For induction and maintenance of general anaesthesia in major surgery with oxygen or nitrous oxide-oxygen mixtures. CII: History of unexplained jaundice or pyrexia after a previous exposure to halothane is an absolute contraindication to its future use in that patient. Halothane is contraindicated in patients with known, or suspected, genetic predisposition to malignant byperpyrexia. S/E & Cautions: Cardio-respiratory depression, bradycardia, fal l of arterial pressure. Halothane can induce liver damage. therefore, any changes or disturbances of liver function including jaundice and enzyme activity (se,rum aminotransferase), usually following repeated administrations (within 4-6 wks), should be monitored & in the case of hepatic impairment. an alternative agent should be used if necessary in this period. _ Pregnancy & hi"ttation: Halothane should be used with care in obstetrics as uterine relaxation and post-partum haemorrhage may result. In early pregnancy, it is better to avoid unless its use is essential. In case of nursing mother, breast feeding should be with-held for about 24 hours after halothane anaesthsia. Dosage & admin: Using a suitable vaporiser, for induction of anaesthesia in the adult patient, a concentration of 2-4 % halothane in oxygen or oxygen/nitrous oxide may be used. In children, a concentation of 1.5-2% halothane in oxygen or oxygen/nitrous oxide is used. A concentration of 0.5-2G is usually

ANAESTHETICS & MUSCLE RELAXANTS

QIMP-lS (389)

adequate for manintenance of anaesthesia in both adults and children_ The lower concentration is usually most suitable for elderly patients_ Drug inter: Cardiac arrhythmias may occur

spinal fluid pressure. Where appropriate, this can

All anaesthetics should be avoided during

be prevented or reversed by hyper-ventilating the

pregnancy if possible. Unavoidable anaesthesia

patient before or during anaesthesia. As with

with isoflurane should be undertaken with due

other halogenated anaesthetics, isoflurane must

caution. A suitable level of anaesthesia for

be used with caution in patients with increased

caesarean section can be maintained with 0.5-

when adrenaline is used concurrently. All

intracranial pressure. Again, in such cases,

0.75% isoflurane in oxygen/nitrous oxide.

commonly used muscle relaxants may be used in

hyperventilation may be necessary.

Increased blood loss has been observed,

conjunction with halothane, but, as halothane

As with all halogenated anaesthetics, repeat

comparable with other volatile anaesthetics (e.g

potentiates the actions of gallamine and d tubocurarine, the doses of these muscle relaxants must be reduced. The association of d tubocurarine with halothane may lead to a marked fall in blood pressure. Potentiation occurs between halothane and hypotensive agents, such as pentolinium and trimetaphan. These drugs must not be used in reduced dosagewhen administered in conjunction with halothane. The use of beta-adrenoceptor antagonists during halothane anaesthesia is at the discretion of the anaesthetist.


.:. HALOSIN Inh_ ACI

Halothane BP 100% v/v: inhalation anaesthetic. 250ml pack: 1 650.00 MRP

ISOFLURANE63 ISOFLURANE: Inhalation Anaesthetic Isoflurane is a colorless non-flammable general inhalation anaesthetic which contains no additive

or stabiliser. It is I -chI oro 2,2,2-trifluoroethyl difluoromethyl ether.

Ind: General inhalation anaesthetic for use in induction and maintenance.

CII: Known sensitivity to isoflurane or to other halogenated agents. Isoflurane should never be given to patients with known or suspected susceptibility to malignant hyperthermia. Isoflurane must not be used in patients who have developed an icterus and/or fever of unknown origin, hepatic impairment or eosinophilia after

anaesthesia within a short period of time should be approached with caution since the risk of hepatotoxicity is not fully understood. There is insufficient experience of use in repeated anaesthesia to make a definite recommendation in this regard. Isoflurane has been reported to interact with dry

halothane), in patients undergoing uterine curettage or other gynaecological surgical procedures. In nursing mother, if isoflurane is necessary to be administered, lactation is to be interruped after the anaesthesia. Lactation can be restarted after the drug has been discharged from the

carbon dioxide adsorbents during closed circuit

circulation.

anaesthesia, to form carbon monoxide. Inhalation

Dosage & admin: Isoflurane has a slight pungent ethereal odour, which may limit the rate of gas induction but, despite this , induction and particularly recovery are rapid_ The use of isoflurane-specific vaporisers will facilitate accurate control of the administered concentration of anaesthetic. The MAC (Minimum Alveolar Concentration), the standard measure of potency for anaesthetics, is 1.15 % in pure oxygen, decreasing to 0_5 % when given with 75% nitrous oxide, for middle-aged humans_ There is an age relationship: the MAC is significantly higher in children and lower in the elderly_

of carbon monoxide may lead to formation of significant levels of carboxyhaemoglobin in exposed patients. e:arboxyhaemoglobin is toxic even in low concentrations and is not easily detected by standard anaesthesia monitors such as pulse oximeters. Direct measurement of carboxyhaemoglobin should be carried out in the event that a patient on closed circuit anaesthesia with an implicated agent develops oxygen desaturation which does not respond to the usual therapeutic measures. All necessary precautions should be taken to ensure that carbon dioxide adsorbents are not allowed to dry out. Caution should be exercised when administering isoflurane to patients with pre-existing liver disease.

Age

Isoflurane is a powerful systemic and coronary arterial dilator. The effect on systemic arterial

Upto 12 mon

pressure is easily controlled in the normal healthy

1 to 5 years

patient and has been used specifically as a means

Ave. COliC. in Qxygell 1 .60- 1 .85% 1 .50-1 .60%

of inducing hypotension. However, the phenomenon of 'coronary steal' means that

Mid-twenties

t .25-t .30%

isoflurane should be used with caution in

Mid-forties

patients with coronary artery disease. In

Mid-sixties

1 . 1 0- 1 .20% 1 .00- 1 . 10%

particular, patients with subendocardial ischaemia might be anticipated to be more susceptible. Salivation and tracheo-bronchial secretions may

MAC

Ave. Cone. with 75% N20 0.49 to 0.69 0.49 to 0.67 Ave. COile. willI 70% N2 0 0.40 to 0.63 0.43 to 0.57 0.33 to 0.41

Premedicatioll: Premedication drugs should

concurrent use of other respiratory depressants.

who receive isoflurane anaesthesia during

be selected according to the needs of the patient. The ventilatory depressant effect of isoflurane should be taken into account_ Anticholinergic drugs (e_g atropine, glycopyrrolate USP) may be used for their effects in drying oral secretions (antisialogogue) at the discretion of the anaesthetist, but they may enhance the weak effects of isoflurane in increasing heart rate. Inductioll: As isoflurane has a mild pungency, inhalation should usually be preceded by the use of a short acting barbiturate, or other intravenous induction agent, to prevent coughing_ Salivation and coughing may be troublesome in small children induced with isoflurane_ Alternatively, isoflurane with oxygen or with an oxygen/nitrous oxide mixture may be administered_ It is recommended that induction with isoflurane be initiated at a concentration of 0.5%_ Concentrations of 1_5-3_0% usually produce surgical anaesthesia in 7-10 minutes_ Blood pressure decreases during induction but this may be compensated by surgical stimulation_

Isoflurane causes an increase in cerebral blood

pregnancy. However, isoflurane is not

Maintenallce: Adequate anaesthesia for

flow at deeper levels of anaesthesia, ( 1 .5%), and

recommended during the first trimester of

this may give rise to an increase in cerebral

pregnancy.

surgery may be sustained with an inspired isoflurane concentration of 1.0-2_5 % in an

administration of isoflurane or another halogenated anaesthetic.

S/E: Adverse reactions encountered with isoflurane are similar to those observed with other halogenated anaesthetics; these are hypotension, respiratory depression and arrhythmias. Other minor side effects encountered while using isof]urane are an increase in the white blood cell count (even in the absence of surgical stress) and also shivering, nausea and vomiting during the postoperative period. These side effects are only observed in a similar number of patietns to .' other anaesthetics. Increase in heart rate has been reported. Rare cases of bronchospasm have been reported. During marketing there have been rare reports of ' mild, moderate and severe (some fatal) post operative hepatic dysfunction. The causal

be stimulated in children but pharyngeal and laryngeal reflexes are quickly diminished. As because, levels of anaesthesia can be altered easily and quickly with isoflurane, only vaporisers which produce a predictable concentration with a good degree of accuracy should be used. The degree of hypotension and ventilatory depression may provide some indication as to the level of anaesthesia. The level of anaesthesia may be changed quickly with isoflurane. Heart rhythm remains stable but spontaneous breathing thould be monitored closely and supported where necessary. It is recommended that vapour from this and other inhalational agents are efficiently extracted from the area of use. Isoflurane should only be administered by, or in the presence of, anaesthetists with the appropriate

relationship is unknown.

anaesthesia 'and resuscitation equipment.

Precautions: Isoflurane has got a profound

Pregnancy & lactation: There are insufficient

respiratory depressant action, this effect is being

data are available on human studies to estimate

accentuated by narcotic premedication or

the risk of teratogenicity in children of women

ANAESTHETICS & MUSCLE RELAXANTS

oxygenl70% nitrous oxide mixture. Additional inspired isoflurane (0.5·1.0% ) will be required with lower nitrous oxide levels, or when isoflurane is given witb oxygen alone or with air/oxygen mixtures. Blood pressure decreases during maintenance anaesthesia in relation to the depth of anaesthesia. That is, blood pressure is inversely related to the isoflurane concentration. Provided there are no other complicating factors, this is probably due to peripheral vasodilation. Cardiac rythm remains stable. Excessive falls in blood pressure may be due to the depth of anaesthesia and in such circumstances this can be corrected by reducing the inspired isoflurane concentration. Induced hypotesion can be achieved by artificially ventilatiug patients with isoflurane 2.5·4.0 % . Pre-treatment with Clonidine significantly decreases the isoflurane requirement for maintaining induced hypotension. Recovery: The concentration of isoflurane can be reduced to 0.5 % at the start of closing the operation wound, and then to 0% at the start of closing the operation wound, and then to 0% at the end of surgery, provided that the anaesthetist is satisfied that the effect of any neuromuscular blocking durgs has been reversed and the patients is no longer paralysed. After discontinuation of all anaesthetics, the airways of the patient should be ventilated several times with oxygen 100% until complete recovery. Drug inter: Please see manufacturer's literature.

Note:

For further information, please contact

manufacturing authority,

: FORANE Inh. Abbott PharmalUniMed

•.

Isoflurane USP, a colourless non-flammable

general inhalation anaesthetic, containing no additive or stabiliser.

QIMP-15 (390)

after a previous halogenated anesthetic.

Sevoflurane is contraindicated in patients with known or suspected genetic susceptibility to malignant hyperthermia, or in patients with a known or suspected history of malignant hyperthermia. Sevoflurane should not be used when general anesthesia is contraindicated.

Precoutions & warnings: Please see the manufacturer's literature.

Dosage & admin:

Dosillg cOllsideratiolls: Fresh gas flow rates of less than 2 IiUmin in a circle absorber system are not recommended, as safety at lower rates has not yet been established. The concentration of sevoflurane being delivered from a vaporizer during anesthesia should be known. This may be accomplished by using a vaporizer calibrated specifically for sevoflurane. The administration of general anesthesia must be individualized based on the patient's response. Pre-allesthetic medicatioll: No specific premedication is either indicated or contraindicated with sevoflurane. The decision as to whether or not to premedicate and the choice of premedication is left to the discretion of the anesthesiologist. Induction: Sevoflurane has a non-pnngent odour and does not cause respiratory irritability; therefore, it is suitable for mask induction in pediatrics and adults. Mailltenance: Surgical levels of anesthesia can usually be achieved with concentrations of 0.5 to 3 % sevoflurane with or withont the concomitant use of nitrous oxide. Sevoflurane can be administered with any type of anesthesia circuit.

Recommended dose & dosage adjustmellt:

MAC (Minimum alveolar concelltratioll) values accordillg to age:

1 00ml bot: 296 1 . 1 6 MRP

SEVOFLURANE63

I -ate 0,5% w/w: eye ointment. 5gm tube: 10,77 MRP

.:. BETACIN·N Eye Drop Ibn Sina

Betamethasone sodium phosphate 0 . 1 %

&

neomycin sulphate 0,5%: eye drop, 5ml drop: 30.34 MRP

.:. BETASON-N Eye Drop Reman

Betamethasone sodiUln phosphate 0. 1 %

&

neomycin sulphate 0,5%: eye drop. 5ml drop: 32.20 MRP

.:. BETASON·N Eye Oint. Reman & neomycin sulphate 0.5%:

Betamethasone 0.1 % eye ointment.

3gm tube: 10.82 MRP

.:. BETRICIN·N E/E Drop Nipa

Betamethasone sodium phosphate 0 . 1 %

&

neomycin sulphate 0.5%: eye/ear drop. 5ml drop: 30.36 MRP

.:. BETRICIN-N Eye Oint. Nipa & neomycin sulphate 0.5%:

Betamethasone 0 . 1 % eye ointment.

3gm tube: 10,77 MRP

.:. BN Eye Drop Asiatic & neomycin sulphate OS70: eye drop Betamethasone 0 . 1 %

5ml drop: 28.45 MRP

.:. METHASOL·N Eye/Ear Drop Gaco Betamethasone 0 . 1 % & neomycin sulphate 0.5%: eye/ear drop 5ml bot: 32,20 MRP

.:. METHASOL·N Eye Oint. Gaco Betamethasone 0, I % & neomycin sulphate 0.5%: eye ointment.

drop.

Betamethasone I mg + neomycin sulph. 5mg/gm:

.;. EYEBET Eye Drop Incepta

Betamethasone sodium phosphate 0, I %: eye

drop. 5ml drop: 30.00 MRP

:. CELUDEX E/E Drop Drug Inter.

•

Betamethasone sodium phosphate 0.1 %: eyelear drop.

5gm tube: 1 2 ,67 MRP

.:. NEOBET·E Eye Oint. Acme

eye ointment.

2.5gm tube: 12.39 MRP 5gm tube: 1 8 . 1 7 MRP

.:. OPTISON·N E/E Drop Opso Saline

Betamethasone sodium 0.1 % + neomycin sulph . 0.5%: eye/ear drop. 5ml vial: 30.30 MRP

.:. OPTISON·N Eye Oint. Opso Saline I mg + neomycin sulph. 5mg/gm:

IOml drop: 55.lXI MRP

Betamethasone

.:. METHASOL Eye/Ear Drop Gaco

eye ointment.

Betamethasone sodium phosphate 0, I %: eye/ear drop. 5ml drop: 3 1 .80 MRP

BETAMETHASONE + NEOMYCIN

stinging, redness, itching, periocular/facial edema, foreign body sensation, photophobia,

&

.:. BETRICIN E/E Drop Nipa

Betamethasone sodium phosphate 0. 1 %: eye/ear 5ml drop: 29.33 MRP

Steroid & Steroid- antibiotic combined prepnS 2 l. 33. I02

ophthalmic preparation is available as

of intraocular pressure (lOP) with possible

Cautions: Pregnancy; concurrent admin. of steroids.

OPHTHALMIC PREPARATIONS

blurred vision, tearing, dryness, and eye pain.

BETAMETHASONE + NEOMYCIN PREPNS: Eye Drop/Ointment

Rare reports of dizziness have been received. The

Betamethasone and neomycin combined

3gm tube: 10.50 MRP

DEXAMETHASONE DEXAMETHASONE PREPNS: Eye drop Dexamethasone only steroid ophthalmic preparation is available as dexamethasone sodium phosphate 0, I % w/v: eye drop. Ind: Non-infected intlammatory ocular


conditions. CII; SIE; Cautions: See at the beginning. Paediatric use only by physicians experienced in ophthalmology. Adult & Child: 1-2 drops every 1 to 4 hours.

•:. ACICOT EIE Drop ACI Dexamethasone sodium phosphate 0. 1 %: eye drop 5ml bot: 60.00 IP

•:. DEXADRON EIE Drop Reman Dexamethasone sodium phosphate 0. 1 %: eye drop 4ml pack: 60.00 MRP •:. DEXACORT EIE Drop Opso Saline Dexamethasone sodium phosphate 0. 1 %: eye drop 5ml bot: 40.00 MRP

.:. DEXAMIN EIE Drop Jayson Dexamethasone sodium phosphate 0. 1 %: eye drop 5ml pack: 50.00 IP .:. DEXAN Eye Drop Chemist Dexamethasone sodium phosphate 0.1 %: eye drop 4ml drop: 28.60 MRP .:. DEXON Eye Drop Ibn Sina Dexamethasone sodium phosphate 0. 1 %: eye drop 5ml drop: 60.00 1P •:. D·ONE Eye Drop Nipa Dexamethasone sodium phosphate 0. 1 %: eye drop Sml drop: 60.00 MRP

.:. MERADEXON Eye/Ear Drop Gaco Dexamethasone sodium phosphate 0. 1 %: eye drop Sml drop: SO.OO MRP .:. METADAXAN Eye Drop Incepta Dexamethasone sodium phosphate 0. 1 %: eye drop Sml drop: 60.00 MRP .:. ORB IDE X Eye Drop Popular Dexamethasone sodium phosphate 0 . 1 %: eye drop 5ml drop: 60.00 MRP •:. SONEXA Eye Drop Aristopharma Dexamethasone sodium phosphate 0 . 1 %: eye drop Sml bot: 60.00 MRP

.:. SONEXA Eye Oint. Aristopharma Dexamethasone 0.05% eye ointment. 3gm tube: SO.OO MRP

DEXAMETHASONE + ANTIBIOTICS DEXAMETHASONE + ANTIBIOTIC PREPNS: Eye Drop/Ointment Dexamethasone and antibiotic combined ophthalmic preparations are. available in, various comhinations. such as: i. Dexamethasone sodium phosphate 0. 1 % w/v + chloramphenicol 0.5% w/v: Eye drop/ointment. ii. Dexamethasone sodium phosphate 0. 1 % w/v + ciprotloxacin 0.3% w/v: Eye drop/ointment. iii. Dexamethasone sodium phosphate 0.1 % w/v + gatitloxacin 0.3% w/v: Eye drop/ointment. iv. Dexi.lInethasone sodium phosphate 0. 1 % w/v + neomycin 0.3S% or O.S% w/v: Eye drop/ointment. v. Dexamethasone sodium phosphate 0. 1 % w/v + tObramycin 0.3% or 0.5% w/v: Eye drop/ointment. vi. Dexamethasone sodium phosphate 0 . 1 % w/v + neomycin 0.5% w/v + polymyxin B sulphate 6000 i.u/gm or m!: Eye drop/ointment.

DEXAMETHASONE + CHLORAMPHENICOL: Eye drop.

QIMP-IS (4[4)

Dexamethasone sodium phosphate 0. 1 % & chloramphenicol 0.5%: eye drop. Ind: Steroid responsive intlammatory ocular conditions where bacterial infections or risk of bacterial infections co-exist. CII; SIE; Cautions: See at the beginning. Paediatric use only by physicians experienced in ophthalmology. Adult & child: 1-2 drops 3 or 4 times daily. .:. CHLORODEX Eye Drop Nipa Dexamethasone sodium phosphate 0.1 % & chloramphenicol O.S%: eye drop. Sml pack: 60.00 MRP .:. CLORAM-D Eye Drop Ibn Sina Dexamethasone sodium phosphate 0 . 1 % & chloramphenicol 0.5%: eye drop. Sml pack: 60.00 MRP .:. DECALOR Eye Drop Jayson . Dexamethasone sodium phosphate 0.1 % & chloramphenicol O.S%: eye drop. Sml pack: 50.00 IP •:. DENICOL Eye Drop ACI Dexamethasone sodium phosphate 0.1 % & chloramphenicol 0.5%: eye drop . 5ml pack: 65.00 IP

.:. DEXACOL Eye Drop Opso Saline Dexamethasone sodium phosphate 0.1 % & chloramphenicol O.S%: eye drop. Sml pack: 4S.00 MRP •:. DEXAGURD Eye Drop Incepta Dexamethasone sodium phosphate 0.1 % & chloramphenicol O.S%: eye drop. Sml pack: 60.00 MRP

.:. DEXCHLOR Eye Drop Gaco Dexamethasone sodium phosphate 0. 1 % & chloramphenicol O.S%: eye drop . Sml pack: 60.00 MRP .:. OPTADEX Eye Drop Reman Dexamethasone sodium phosphate 0. 1 % & chloramphenicol 0.5%: eye drop. 5ml drop: 70.00 MRP .

•:. OPTICOL-D Eye Drop Asiatic Dexamethasone sodium phosphate 0. 1 % & chloramphenicol O.S%: eye drop. Sml drop: 50.00 MRP

.:. ORBIDEX C Eye Drop Popular Dexamethasone sodium phosphate 0. 1 % & chloramphenicol O.S%: eye drop. Sml drop: 60.00 MRP .:. SONEXA-C Eye Drop Aristopharma Dexamethasone sodium phosphate 0. 1 % & chloramphenicol O.S%: eye drop. 5ml drop: 60.00 MRP :. STENICOL Eye Drop Drug Inter. Dexamethasone sodium phosphate 0. 1 % & chloramphenicol O.S%: eye drop. SI11I drop: SO.OO MRP •

DEXAMETHASONE + CIPROFLOXACIN: Eye drop/ointment."" Dexamethasone sodium phosphate 0. 1 % & ciprolloxacin 0.3%: eye/ear drop. Ind: Steroid responsive intlammatory ocular conditions where bacterial infectiol1f; or risk of bacterial infections co-exist. C/I: This combined eye product is contraindicated in fungal diseases of ocular structures, viral conjunctivitis und

hypersensitivity to any of the components of the fornmlation. SIE: Frequently reported reactions related to this combination product are transient ocular burning or discomfort. Other repo.1ed reactions include chemosis, redness, dry eye. pain, itching, swelling of the eyelid & reduced visual acuity. The reactions due to steroid component are elevation of intraocular pressure (lOP) with possible development of glaucoma, infrequent optic nerve damage, delayed wound healing and posterior subcapsular cataract formation. Secondary infection may develop after use of combination containing steroid & antibacterial. Fungal or viral infections of the cornea are pa.1icularlY prone to develop coincidently with long term lise of steroids. Pregnancy & lactation: This combined eye product should be used during pregnancy only if the potential benefit j ustifies the potential risk to the foetus. Caution should be exercised when the combination is administered to n nursing woman . Precautions & warning: If the product is used for 10 days or more, intraocular pressure should be monitored routinely. Prolonged llSe: of steroid may result in glaucoma. elevated intraocular pressure or other ocular damages. It may exacerbate severity of viral infections. Use cautiously in patients with history of herpes simplex . Paediatric use only when adviced by the physicians experienced ill ophthalmology. Use & appli: Adult & Child: 1-2 drops every 4 to 6 hours. During initial 1 to 2 days the dosage may be increased to 1 to 2 drops every 2 hours. Frequency should be decreased gradnally or warranted in clinical signs. Care should be taking not to discontinue therapy prematurely. .:. APRODEX E/E Drop Aristopharma Dexamethasone sodium phosphate 0. 1 % & ciprotloxacin 0.3%: eye/ear drop . Sml drop: 7S.00 MRP .:. BACTIN·D Eye Drop Ibn Sina Dexamethasone sodium phosphate 0. 1 % & ciprotloxacin 0.3%: eye/ear drop. Sml drop: 7S.00 MRP .:. BEUFLOX-D Eye Drop Incepta Dexamethasone sodium phosphate 0. 1 % & ciprotloxacin 0.3%: eye/ear drop. 6ml drop: 7S.00 MRP .:. CERODEX Eye Drop Gaco Dexamethasone sodium phosphate 0. 1 % & ciprofloxacin 0.3%: eye/ear drop . Sml drop: 6S.00 MRP .:. CIP-D Eye Drop Asiatic Dexamethasone sodium phosphate 0. 1 % & ciprofloxacin 0.3%: eye/ear drop. Sml drop: 75.00 MRP .:. ClPROZID-DX Eye Drop Drug Inter. Dexamethasone sodium phosph.lte 0. 1 % & ciprotloxacin 0.3%: eye drop. 1 0mi drop: 60.00 MRP .:. CIVODEX EIE Drop Popular Dexamethasone sodium phosphate 0. 1 % & ciprotloxacin 0.3%: eye/ear drop. Sml drop: 75.00 MRP .:. OPDEX EIE Drop Nipa Dexamethasone sodium phosphate 0. 1 % & ciprotloxacin 0.3%: eye/ear drop.

QIMP,15 (415)

5ml drop: 75.00 MRP

DEXAMETHASONE + GATIFLOXACIN: Eye drop, lOI Dexamethasone sodium phosphate BP 0. 1 % & gatifloxacin 0.3% as gatifloxacin sesquihydrate INN: eye drop. Ind: Steroid responsive inflammatory ocular conditions where bacterial infections or risk of bacterial infections co-exist. CII; SIE;' Cautions: See above under the dexamethasone & ciprot1oxacin eye preparation. Use & appli: 1,2 dropsinto the conjunctival sac 3 to 4 times a day, Pediatric use: The safety in pediatric patients has not been established, .:. GATIDEX Eye Drop Opsosaline Dexamethasone sodium phosphate BP 0. 1 % & gatit10xacin 0.3% as gatit10xacin sesquihydrate INN: eye drop. 5ml drop: 60.00 MRP

DEXAMETHASONE + NEOMYCIN + POLYMYXIN B: Eye drop/ointment, Dexamethasone 0. 1 % , neomycin sulph. 0.35%, polymyxin B sulph. 6000 i.u./ml; eye drop. Ind: Infected ocular infalmmation. Cautions: Paediatric use only by physicians experienced in ophthalmology. Adult & Child: 1-2 drops 3 to 4 times daily or more frequently if reqd, .:. FLAMITROL Eye Drop Gaco Dexamethasone 0 . 1 % , neomycin sulph. 0.35%, polymyxin B sulph.6000 i.u./ml; eye drop. 5ml drop: 60.00 MRP .:. MAXITROL Eye Drop AlconlGlobex Dexamethasone 0 . 1 %, neomycin sulph. 0.35% & polymyxin B sulph 6000 i .u/inl: eye drop. 5ml drop: 1 55 .00 TP .:. NEO-DP Eye Drop Drug Inter, Dexamethasone 0 . 1 %, neomycin sulph. 0.35% & polymyxin B sulph.6000 i.u/ml: eye drop. 5ml drop: 90.00 MRP .:. POLYDEX-N Eye Drop Aristopharma Dexamethasone 0. 1 %, neomycin sulph. 0.5% & polymyxin B sulph.6000 i.u/ml: eye drop. 5ml drop: 60.00 MRP .:. POLYDEX-N Eye Oint Aristopharma Dexamethasone 0 . 1 %, neomycin sulph. 0.5% & polymyxin B sulph.6000 i.u/gm: eye ointment. 3gm tube: 25.00 MRP

DEXAMETHASONE + TOBRAMYCIN: Eye drop/ointment, Dexamethasone 0 . 1 % and tobramycin 0.3%: Eye drop & ointment. Ind: Steroid responsive int1ammatory ocular conditions where bacterial infections or risk of bacterial infections co-exist. CII; SIE; Cautions: See above under the text of tobramycin & dexamethasone eye products. Dosage & admin: Eye drop: 1 or 2 drops instilled into the conjunctival sac(s) every 4 to


6 hours, During the initial 24 to 48 hurs, the dosage may be increased to 1-2 drops every two hours. Frequency should be decreased gradually as warranted by improvement in clinical signs, Care should be taken not to discontinue therapy prematurely, Ointment: apply a small amount into the conjunctival sac(s) up to 3 or 4 times daily, After applying ointment, look downward before closing the eye, Ointment may be used at bedtime in conjunction with suspension used during the day, .:. D.EXTROBAC Eye Drop Incepta Dexamethasone 0. 1 % and tobramycin 0.3%: drop. Sml drop: 125.00 MRP .:. EYTEX Eye Drop/Oint Nipa Dexamethasone 0. 1 % and tobramycin 0.3%: drop & ointment. 5ml drop: 1 25.00 MRP 3gm oint: 90.00 MRP .:. ORBIDEX T Eye Drop popular Dexamethasone 0.1 % and tobramycin 0.3%: drop. 5ml drop: 1 30.00 MRP .:. T-DEX Eye Drop/Oint. Reman Dexamethasone 0 . 1 % and tobramycin 0.3%: drop & ointment. 5ml drop: 125 .00 MRP 4gm oint: 65.00 MRP .:. T-MYCIN Plus Eye Drop/Oint, Aristopharma Dexamethasone 0. 1 % and tobramycin 0.3%: drop & ointment. 5ml drop: 1 30.00 MRP 3.5gm oint: 90.00 MRP

eye

severe blood circulation diseases (e.g coronary heart condition, hypertonia, phaeochromocytoma); metabolic disturbances (e.g hyperthyroidism, diabetes); patients under treatment with MAOls & other potentially hypertensive drugs; history of cataract, herpes simplex infection or rhinitis sicca. Uses & appli: Adults: 1 drop 2-3 times daily into the conjunctival sac; in the first 24-48 hours, the dose may be increased to 1 drop hourly for adults; caution should be exercised in the case of reactive hyperaemia, Children: (above 2 years)- as, no specific studies have been performed & due to possible systemic adverse effects, efemoline should be used with caution in children,

eye

eye

eye

eye

.:. TOBIDEX Eye Drop/Oint Gaco Dexamethasone 0 . 1 % and tobramycin 0.3%: eye drop & ointment. 5ml drop: 12 5 .00 MRP 3.Sgm oint: 89.99 MRP .:. TOMYCIN-D Eye Drop Ibn Sina Dexamethasone 0 . 1 % and tobramycin 0.3%: eye drop & J'intment. Sml drop: 125.00 MRP

FLUOROMETHOLONE PREPNS54 FLUOROMETHOLONE: Eye Drop F1uorometholone 0 . 1 % ( l mg/ml): eye drop Ind: Chronic int1ammation of the eye, angular. allergic conjunctivitis, blepharitis, acute allergic non-infectious conjunctivitis and keratitis with severe swelling and hyperaemia; non-infectious inflammation of the anterior segment of the eye (including anterior uveitis, episcleritis and scleritis); post-operative conditions following squint, cataract and glaucoma operations along with supplementary antimicrobial therapy. CII: See above under steroid preparations; hyper, sensitivity to fluorometholone, & other ingredients; dry eyes, specially keratoconjunctivitis sicca (Sjogren's .syndrome); children under 2 years. SIE: See above under steroid preparations; prolonged use may give rise to reactive hyperaemia (rebound effect). Precautions: The preparation should only be administered after a careful risklbenefit evaluation in each individual patient in case of-

.:. AFM Eye Drop Aristopharma Fluorometholone 0.1 % ( lmg/ml): eye drop Sml drop: 85.00 MRP .:. EYLON Eye Drop Ibn Sina Fluorometholone 0. 1 % (I mg/m!): eye drop Sml drop: 96.00 MRP .:. FLAREX Eye Drop AlconlGlobex Fluorometholone 0. 1 % ( lmg/ml): eye drop Sml drop: 163.50 TP .:. FLUCORT Eye Drop Gaco Fluorometholone 0 . 1 % ( lmg/ml): eye drop Sml drop: 82.00 MRP .:. FLUMETH Eye Drop Nipa Fluorometholone 0. 1 % ( lmg/ml): eye drop Sml drop: 82.00 MRP .:. FLUROMET Eye Drop Popular Fluorometholone 0 . 1 % ( lmglml): eye drop Sml drop: 85.00 MRP .:. NGS Eye Drop Opso Saline Fluorometholone 0. 1 % ( Imglml): eye drop Sml drop: 85.00 MRP .:. REFEMOLINE Eye Drop Reman Fluorometholone I mg & tetrahydrozoline hydrochloride 0.2Smg/ml: eye drop. Sml drop: 95.00 MRP

FLUOROMETHOLONE + GENTAMICIN54 FLUOROMETHOLONE + GENTAMICIN: Eye Drop/Ointment Fluorometholone I mg & gentamicin sulphate 3mg/lml: eye drop Ind: Infected ocular inflammation of the anterior segment of the eye due to bacteria susceptible to gentamicin (e.g bacterial conjunctivitis). Adult & Child: Eye drop: 1-2 drops 5 times daily in the affected eye(s); in severe cases may be given 1 drop per hour for 1 to 2 days, In ocular post-operative treatment- 1 drop 4 times daily for 1 week, then reduced application frequency for the remaining part of the treatment.

QIMP.15 (416)


Eye ointment: Apply 3·4 tiines daily into the ' affected eyers). Ocular post·operative treatment· to support the therapy with eye drop during the night apply the ointment before going to bed. :. AFM·Plus Eye Drop Aristopharma & gentamicin sulphate

•

F1uorometholone 1 mg 3mgl l ml : eye drop

5ml drop: 1 10.00 MRP

.:. AFM·Plus Eye Oint. Aristopharma F1uorometholone 1 mg & gentamicin sulphate 3mgl 1 gm: eye ointment. 3gm tube: 100.00 MRP

.:. FLUMELONE·N Eye Drop Reman F1uorometholone 1 mg & gentamicin sulphate

3mgl l ml: eye drop

5ml drop: 90.00 MRP

HYDROCORTISONE PREPNS I03 .:. NPH Eye Drop Reman

Hydrocortisone acetate IOmg/ml ( l %),

neomycin sulph. 3400 units/ml (0.34%),

the potential risk to the fetus. Due to serious

adverse reactions in nursing infants from

prednisolone acetate, a decision should be made

cataract surgery include· abnormal sensation in

the eyers), conjunctival hyperemia, eye irritation

(including burning/stinging), eye pain, eye

whether to discontinue nursing or to discontinue

pruritus, eye redness, headache and iritis. These

the drug to the mother.

Precautions: All topical nonsteroidal anti·

the drug, taking into account the importance of

Dosage & admin: Two drops in the eye (s) four ' . times daily. In cases of bacterial infections, concomitant use of anti·infective agents is mandatory. Children: Safety and effectiveness in pediatric patients have not been established. .:. CORTISOL Eye Drop Aristopharma

Prednisolone acetate USP 1 % w/v: eye drop 5ml drop: 90.00 MRP

.:. OCUSOL Eye Drop Popular


.:. PEDNISOL Eye Drop Drug Inter.


:. PREDNOL Eye Drop Reman

•


events were reported in 2-7% of patients.

inflammatory drugs (NSAIDs) may slow or delay

healing. Use of topical NSAIDs may result in

keratitis. In some susceptible patients, continued use of topical NSAIDs may result in epithelial

breakdown, corneal thinning, corneal erosion,

corneal ulceration or perforation. ' Postmarketing experience with topical NSAIDs suggests that patients with complicated ocular

surgeries, corneal denervation, corneal epithelial

defects, diabetes mellitus, ocular surface diseases (e.g. dry eye syndrome), rheumatoid arthritis, or

repeated ocular surgeries within a short period of

time may be at increased risk for corneal adverse events which may become sight threatening.

Topical NSAIDs should be used with caution in

these patients .


and well·controlled studies in pregnant women. So, this drug should be used during pregnancy

only if the potential benefit justifies the potential

polymyxin·B sulph. 10,000 units/ml; eye drop

Ind: Inflammatory ocular conditions for which a

PREDNISOLONE + ANTIBIOTICS62.l o2

risk to the fetus. Caution also should be exercised

bacterial ocular infection or a risk of infection

.:. DELTASONE·N E/E Drop Renata Prednisolone acetate 5mg & neomycin sulphate

administered to a nursing woman.

corticosteroid is indicated and where superficial exists.

CIl: Viral infections. S/E: See above under the text of steroid. Cautions: Paediatric use only by physicians experienced in ophthalmology.

Adult & Child: 1·2 drops 3 to 4 times daily or more frequently if required.

5mg/ l ml : eye/ear drop.

Ind: Infected ocular & ear inflammation. Adult & Child: 1·2 drops 3 to 4 times daily or more frequently if requred. 5ml drop: 39.98 MRP

5ml vial: 45.00 MRP

Non-Steroid drugs PREDNISOLONE PREPNS36 PREDNISOLONE ACETATE: Eye Drop

Prednisolone acetate USP 1 % w/v: eye drop

Mode of action: Prednisolone, a corticosteroid, is thought to act by the induction of

phospholipase A2 proteins, which control the

biosynthesis of potent mediators of inflammation

such as prostaglandins and leukotrienes by

inhibiting the release of their common precursor

arachidonic acid.

when bromfenac ophthalmic solution is

Dosage & admin: For the treatment of postoperative inflammation, 1 drop of bromfenac 0.09% ophthalmic solution should be applied to the affected eyers) 2 times daily beginning 24 hours after ocular surgery and continuing through the first 2 weeks of the postoperative period. Children: Safety and efficacy in pediatric patients below the age of 18 have not been established. Drug inter: Topical corticosteroids are known to slow or delay healing. Therefore, concontitant

BROMFENACl 33

use of topical NSAIDs and topical steroids may increase the potential for healing problems.

BROMFENAC: Eye Drop

Bromfenac is a nonsteroidal anti·inflammatory

.:. BFENAC Eye Drop Popular

drug, available as ophthalmic solution for topical

Each ml of eye drop' contains- bromfenac sodium

Comp: Each ml of eye drop contains- bromfenac sodium INN equivalent to bromfenac 0.9mg &

benzalkonium chloride 0.05mg as preservative:

adntinistration in the eyes.

benzalkonium chloride 0.05mg as preservative.

Mode of action: The mechanism of anti

INN equivalent to bromfenac 0.9mg

&

eye drop.

5ml drop: 95.00 MRP

.:. BROMOFEN Eye Drop Ibn Sina

Ind: Allergic conjunctivitis, acne rosacea,

inflammatory activity is thought to be due to its

Each ml of eye drop contains- bromfenac sodium

cyclitis,

inhibiting cyclooxygenase 1

& benzalkonium chloride O.05mg as preservative:

superficial keratitis, herpes zoster keratitis, iritis,

& selected infective conjunctivitis in

addition to antibiotic therapy.

CIl: Prednisolone is contraindicated in most viral

diseases of the cornea and conjunctiva.

S/E: Elevation of intraocular pressure (lOP) with

possible development of glaucoma and infrequent optic nerve damage, cataract formation.

& posterior subcapsular

Precautions & warnings: If thi� 'l'edication is

ability to block prostaglandin synthesis by

& 2. Prostaglandins

have been shown in many animal models to be

mediators of certain kinds of intraocular

inflammation. In studies performed in animal

INN equivalent to bromfenac 0.9mg (i.e 0.09%)

eye drop.

5ml drop: 95.00 MRP

.:. XIROM Eye Drop Aristopharma

eyes, prostaglandins have been shown to produce

Each ml of eye drop contains- bromfenac sodium

vasodilation, increased vascular permeability,

& benzalkonium chloride 0.05mg as preservative:

disruption of the blood-aqueous humor barrier,

leukocytosis and increased intraocular pressure.

Ind: Bromfenac ophthalntic solution is indicated

INN equivalent to bromfenac 0.9mg (i.e 0.09%)

eye drop.

5ml drop: 95.00 MRP

used for 10 days or longer, mtraocular pressure

for the treatment of postoperative inflammation

corticosteroids may result in glaucoma with

undergone ocular surgery (cataract extraction,

DICLOFENAC SODIUM21.33

acuity and fields of vision, and in posterior

CIl: Known hypersensitivity to bromfenac,

DICLOFENAC SODIUM: Eye Drop.

Pregnancy & lactation: Prednisolone acetate

in this product.

anti·inflammatory

reactions following use of bromfenac after

penetrating wound; inhibition of miosis during

should be monitored. Prolonged use of

damage to the optic nerve, defects in visual subcapsular cataract formation.

ophthalntic suspension should be used during

pregnancy only if the potential benefit justifies

and reduction of ocular pain in patients who have

IOL implantation etc).

benzalkonium chloride or any other ingredients

S/E: The most commonly reported adverse

Diclofenac sodium, a nonsteroidal substance with

& analgesic effects: eye drop. Ind: Ch. non-infectious conjunctivitis,

QIMP-15 (417) cataract surgery; post operative & pre-operative

Precautions: It should be. used with caution in

prevention of cystoid macular oedema associated

patients with known bleeding tendencies or who

implantation.

prolong bleeding time. There is the potential for

with lens extraction

& intraocular lens

Use: 1 drop 3-5 times daily. .:. ANFENAC Eye Drop Nipa

Diclofenac sodium 0. 1 %: eye drop.

Sml drop: 80.00 MRP

.:. ANODYNE Eye Drop Ibn Sina

Diclofenac sodium 0. 1 %: eye drop. Sml drop: 75.00 IP

.:. C-FENAC Eye Drop Chemist

Diclofenac sodium 0 . 1 %: eye drop. Sml drop: 6S.00 MRP

.:. CLOFENAC Eye Drop Square

Diclofenac sodium 0. 1 %: eye drop. Sml drop: 7S.00 MRP

: DICLOFEN Eye Drop Opso Saline

•.

Diclofenac sodium 0 . 1 %: eye drop. Sml drop: 60.00 MRP

:. DICLON Eye Drop Reman

•

Diclofenac sodium 0 . 1 %: eye drop.

Sml drop: 78.00 MRP

:. ERDON Eye Drop Aristovision

•

Diclofenac sodium 0. 1 %: eye drop. 5ml drop: 80.00 MRP

:. INTAFENAC Eye Drop Incepta

•


.:. LOCOPAIN Eye Drop Asiatic


are receiving other medications which may


Ind: Ketotifen is indicated for the treatment of allergic conjunctivitis.

CII: Ketotifen is contraindicated in patients with

hypersensitivity to any of its ingredients.

cross-sensitivity to acetyls-alicylic acid,

SIE: Drowsiness and in isolated cases dry mouth

anti-inflammatory agents. Therefore one should

the treatment, but usually disappear

phenylacetic acid derivatives, & other nonsteroidal be careful when treating individuals who have

previously exhibited sensitivities to these drugs.

With some nonsteroidal anti-inflammatory drugs,

there are potential for increased bleeding time due to interference with thrombocyte

aggregation. There have been reports that

ocularly applied nonsteroidal anti-inflammatory drugs may cause increased bleeding of ocular

and slight dizziess may occur at the beginning of

spontaneously after a few days.

Precautions: As with all ophthalmic preparations containing benzalkonium chloride, patients are advised not to instill ketotifen fumarate

ophthalmic solution while wearing soft

(hydrophilic) contact lenses. Wearers of soft

contact lenses should be instructed to remove

lenses prior to installation of drops and to wait at

tissues (including hyphemas) in conjunction with

least ten minutes after instilling ketotifen before


Do not use longer than one month after opening .

ocular surgery.

and well-controlled studies in pregnant women.

Ketorolac tromethamine should be used during pregnancy only if the potential benefit justifies

the potential risk to the fetus. Caution should be

they insert their contact lenses.

Pregnancy & lactation: Ketotifen should not be used during pregnancy, except if the benefit

justifies the potential risk to the fetus .

Dosage & admin: Adult- 1 drop 4 times a day or as advised by the physician. Children- not recommended as safety and efficacy in pediatric patients have not been established. Drug inter: Methotrexate, diuretics. lithium,

Dosage & admin: Adults and children over 3 years of age: The recommended dose is one drop in the affected eye(s) 8 to 12 hourly or as directed by the physician. If dose misses, apply as soon as possible; not apply if almost time for the next dose. Children below 3 years of age: Not recommended,

.:. EMODOL Eye Drop Jayson

Ketotifen fumarate BP 0.02S%: eye drop

exercised when it is administered to a nursing

woman .

warfarin, digoxin and other NSAIDs.

.:. ALARID Eye Drop Square

Ketorolac tromethamine O.S% sterile isotonic

5ml drop: 9S.00 MRP


Sml drop: 60.68 IP


.:. NOPAIN Eye Drop Drug Inter.


Sml drop: 70.00 MRP

5ml drop: 80.00 MRP

Sml drop: 80.00 MRP

:. MOBIFEN Eye Drop ACI

•

Sml drop: 7S.00 MRP


.:. PROFENAC Eye Drop Popular


.:. REUTREN Eye Drop Gaco

Diclofenac sodium 0 . 1 %: eye drop.

Sml drop: 70.00 MRP

aqueous solution for ophthalmic use: eye drop.

.:. ETOLAC Eye Drop Ibn Sina

Sml drop: 7S.00 MRP



.:. ETORAC Eye Drop Incepta


KETOROLAC TROMETHAMINE: Eye Drop Ketorolac tromethamine is a nonsteroidal anti

inflammatory drug, available for ophthalmic use

as O.S% (Smglml) sterile isotonic aqueous solution or eye drop.

Mode of action: Its action is thought to be due,

in part, to its ability to inhibit prostaglandin

biosynthesis. Ocular administration of ketorolac

tromethamine reduces prostaglandin E2 levels in

aqueous humor. It has no significant effect upon intraocular pressure.

Ind: Indicated for- i. the relief of ocular itching

.:. KETOF Eye Drop Ibn Sina

5ml drop: 9S.00 MRP

.:. KETOMAR Eye Drop Incepta

Ketotifen fumarate BP 0.03%: eye drop

aqueous solution for ophthalmic use: eye drop

5ml drop: 9S.00 MRP

.:. KEROLAC Eye Drop Gaco


Sml drop: 60.68 IP

.:. PROSMA Eye Drop ACI

Ketorolac tromethamine 0.5% sterile isotonic

Sml drop: 80.00 MRP

Sml drop: 60.00 MRP

Ketotifen fumarate BP 0.03%: eye drop

aqueous solution for ophthalmic use: eye drop

KETOROLACJ9

.:. FENAT Eye Drop Drug Inter.

.:. STAFEN Eye Drop Aristopharma

.:. LOPADOL Eye Drop Popular

Sml drop: 95.00 MRP



Ketorolac tromethamine O.S% sterile isotonic 5ml drop: 80.00 MRP

.:. ZADIT Eye Drop Popular

Sml drop: 95.00 MRP

.:. ORADOL Eye Drop Aristopharma


aqueous solution for ophthalmic use: eye drop. 5ml drop: 80.00 MRP

.:. RECULAR Eye Drop Reman


aqueous solution for ophthalmic use: eye drop. 5ml drop: 80.00 MRP

LODOXAMIDE I02 .:. ALOMIDE Eye Drop AlconlGlobex

Lodoxamide tromethamine 0.17% equivalent to

0. 1 % lodoxamide + benzalkonium chloride

0.007% as preservative: Eye drop.

Mode of action: Lodoxamide tromethamine has

antiallergic properties. It stabilizes mast cells and

due to seasonal allergic conjunctivitis, ii.

KETOTIFEN52

prevent the antigen specific induced release of

associated symptoms following ocular surgery.

KETOTIFEN: Eye drop

other mast cell inflammatory mediators such as

patients having hypersensitivity reaction to

Mode of action: Ketotifen fumarate is a non

and disodium edetate.

anti-anaphylactic property. In addition, ketotifen

histamine. Lodoxamide prevents the release of

prophylaxis and reduction of inflammation and

CII: Patients wearing soft contact lenses and

ketorolac tromethamine. Benzalkonium chloride

SIE: Transient stinging and burning on

instillation, ocular irritation, allergic reactions, superficial ocular infections

& superficial keratitis.

Ketotifen fumarate BP 0.02S% eye drops.

the slow reacting substances of anaphylaxis (or

bronchodilator antiasthmatic drug with marked

preventing the movement of calcium into the

exerts a powerful and sustained H I receptor

Ind: Allergic/atopic conjunctivitis, vernal

from its anti-anaphylactic property.

CII: Hypersensitivity to lodoxamide or any

blocking activity which can be clearly dissociated

SRS-A). It inhibits histamine release by

mast cell after stimulation.

conjuctivitis and giant papillary conjuctivitis.

QIMP-15 (418)


.:. ALACOT Eye Drop Square

pemirolast eye drop is administered to a nursing

expressed as burning, stinging, itching or tearing.

Eye drop

Warnings & precautions: As with all

Sml drop: 100.00 MRP

chloride, users of soft (hydrophilic) contact lenses

Olopatadine hydrochloride INN I mg/ml (0.1%):

Dosage & admin: 1 to 2 drops in each affected eye 4 times daily. Pediatric use: Safety & effectiveness in pediatric patients below the age of 3 years have not been established. Drug inter: No specific information is available.

component of the preparation.

SIE: Mild & transient discomfort upon instillation


ophthalmic preparations containing benzalkonium

.:. LOPADlNE Eye Drop Incepta

should refrain from wearing lenses while under

Eye drop

treatment with lodoxamide. The recommended

Smi drop: lOO.OO MRP

frequency of administrations should not be

.:. OLODIN Eye Drop Reman

exceeded.

Olopatadine hydrochloride INN I mg/mi (0.1 %):

Pregnancy & lactation: There is no study of

Eye drop

lodoxamide use during pregnancy or concerning

Sml drop: lOO.OO IP

excretion in human milk.

.:. OLPADIN Eye Drop Aristopharma

Dosage & admin: Adult & older children- 1 or 2 drops in each eye 4 times a day at regular intervals. Once symptomatic improvement has been established, therapy should be continued for as long as needed to sustain improvement. If required, corticosteroids may be used concomitantly with lodoxamide_ Clinical studies on use in children below the age of four years have not been performed. Overdose: In the event of topical overdose, flush from the eye with running water.

Storage: Store at room temperature and use within one month after opening the drop.

Sml drop: 257.20 TP

OLOPATADINE42

Olopatadine hydrochloride INN I mg/ml (0.1%): Eye drop

woman.

.:. MIROLAST Eye drop Incepta

Pemirolast potassium INN 0. 1 % (i.e lmg/ml): eye drop. 1 0mi drop: 7S.00 MRP

.:. PEMAST Eye drop Opso Saline

Pemirolast potassium INN 0 . 1 % (i.e I mg/ml):


eye drop.

.:. PATADIN Eye Drop Popular

1 0mi drop: 7S.00 MRP

Olopatadine hydrochloride INN I mg/ml (0.1 %): Eye drop Sml drop: 100.00 MRP

SODIUM CROMOGLYCATE21,33

.:. PATALON Eye Drop Ibn Sina

Olopatadine hydrochloride INN I mg/mi (0. 1 %): Eye drop Sml drop: 100.00 MRP

:. PATANOL Eye Drop AlconlGlobex

•

Olopatadine hydrochloride INN I mg/mL (O.I%): Eye drop Smi drop: 460.00 TP

PEMIROLAST26

SODIUM CROMOGLYCATE: Eye Drop Sodium cromoglycate 2% & 4%: eye (& nasal) drop .

Ind: Allergic conjuctivitis; a mast cell stabiliser. CII: Soft contact lenses. SIE: Transient stinging. Dosage & admin: Adult & child: 1 or 2 drops in each eye, 4 times daily. .:. ARISTOCROM Eye Drop Aristovision (& nasal) drop.

Sodium cromoglycate 2%: eye

OLOPATADINE: Eye Drop

PEMIROLAST: Eye drop

1 0mi drop: 6S.00 MRP

Pemirolast potassium is a mast cell stabilizer. It is

Eye drop

available as pemirolast potassium INN 0.1 % (i.e

.:. CROMOLIN Eye Drop Ibn Sina Sodium cromoglycate 4%: eye (& nasal) drop.

I mg/mI) topical ophthalmic solution.

IOml drop: 7S.00 MRP

histamine from the mast cell and a relatively

Mode of action: As pemirolast potassium is a

.:. ICROM Eye Drop ACI


Mode of action: Olopatadine inhibits release of selective histamine H I-antagonist. It inhibits the

in vivo and in vitro type I immediate hypersensitivity reaction including inhibition of histamine induced effects on human conjunctival epithelial cells.

Ind: Olopatadine 0 . 1 % eye drop is indicated for

the treatment of the signs and symptoms of

mast cell stabilizer, it inhibits the invivo type- I immediate hypersensitivity reaction. The drug has been observed to block antigen-stimulated calcium ion influx into mast cells. Invitro and invivo studies have demonstrated that pemirolast inhibits the antigen-induced release of inflammatory mediators (e.g histamine,


(& nasal) drop.

I Oml drop: 6S.00 MRP

.:. ITCHIN Eye Drop Gaco


(& nasal) drop.

IOml drop: 60.00 MRP

.:. ITCHIN'DS Eye Drop Gaco (& nasal) drop.


leukotriene C4, 04, E4) from human mast cells.

IOml drop: 7S.00 MRP

CII: Olopatadine preparation is contraindicated

Pemirolast also inhibits the chemotaxis of

.:. MASTGUARD Eye Drop Incepta Sodium cromoglycate 2%: eye (& nasal) drop.

olopatadine hydrochloride.

inflammatory mediator release from human

I Oml drop: 60.00 MRP

SIE: Headaches have been reported in 7% cases.

eosinophils.

.:. NACROMIN Eye Drop Square Sodium cromoglycate 2%: eye (& nasal) drop.

S% of patients, such as- asthenia, blurred vision,

prevention of itching of the eye du� to allergic

I Oml drop: 61 .00 MRP

conjunctivitis.

.:. NASOCHROM Eye Drop Drug Inter. Sodium cromoglycate 2%: eye (& nasal) drop.

allergic conjunctivitis.

in persons with known hypersensitivity to

Other side effects are experienced in less than burning or stinging, cold syndrome, dry eye,

foreign body sensation, hyperemia, hypersensi tivity, keratitis, lid edema, nausea, pharyngitis, pruritus, rhinitis, sinusitis and taste change.

eosinophils into ocular tissue and prevents

Ind: Pemirolast eye drop is indicated for the

CII: Known hypersensitivity to any of the

ingredients of the product.

IOml drop: 60.00 MRP

SIE: Burning of eye, dry eye, ocular discomfort,

.:. OPSOCROM Eye Drop Opso Saline Sodium cromoglycate 2%: eye (& nasal) drop.

Precautions: Olopatadine ophthalmic solution

non ocular allergy, sinusitis, headache and

irritation. Patients who wear soft contact lenses

Precautions: Patients should be advised not to

should not be used to treat contact lens related

should be instructed to wait at least ten minutes after instilling olopatadine eye drop before they insert their contact lenses.

sneezing or nasal congestion. wear contact lens if their eye(s) are red.

Pemirolast should not be used to treat contact lens related irritation. Patients should wait 1 0


minutes after applying pemirolast before they

and well controlled studies in pregnant women.

insert contact lenses.

So, this drug should be used in pregnant women


only if the potential benefit to the mother justifies the potential risk to the fetus. Caution should be exercised when olopatadine ophthalmic solution is administered to a nursing mother.

Dosage & admin: One drop in each affected eye 2 times/day at an interval of 6 to 8 hours.

and well-controlled studies in pregnant women.

Pemirolast eye drop should be used during pregnancy only if the benefit outweighs the risk. It is not known whether pemirolast is excreted in

IOmi pack: SS.OO MRP

.:. OPTACROM Eye Drop Reman Sodium cromoglycate 2%: eye (& nasal) drop. I Oml drop: 60.00 MRP

.:. OPTIPAN Eye Drop Jayson Sodium cromoglycate 2%: 'eye (& nasal) drop. I Oml drop: SO.57 MRP

.:. SODICROM Eye Drop Popular Sodium cromoglycate 2%: eye (& nasal) drop. I Oml drop: SO.OO MRP

human milk. Because many drugs are excreted in

.:. SODICROM DS Eye Drop Popular Sodium cromoglycate 4%: eye (& nasal) drop.

human milk, caution should be exercised when

I Oml drop: 7S.00 MRP

QIMP-1S (419)


with the dropper tip of the bottle.

Non-Steroid Combined Prepns.

1 0mi drop: 37.64 MRP

I Sml drop: 1 02.S2 TP

NAPHAZOLINE + ZINC SULPHATE54

ANTAZOLINE + TETRYZOLINE54 .:. SPERSALLERG Eye drop Novartis & tetryzoline

Antazoline hydrochloride O.Smg

NAPHAZOLINE + ZINC SULPHATE: Eye drop Naphazoline nitrate BP O.OOS% (O.OSmg/ml) & zinc sulphate BP 0.02% (0.02mg/l ml): Eye drop.

hydrochloride O.4mg/ml: eye drop.

Ind: Acute & chronic non-infectious

Ind: Non- infectious allergic conjunctivitis, hay

conjunctivitis; non-specific conjunctival initation

fever, conjunctivitis vernalis.

(also after successful treatment of bacterial and

CII: Hypersensitivity to any part of spersallerg;

viral conjunctivitis); irrigation of the tear ducts.

narrow angle glaucoma; 'dry eye' syndrome;

CII: Hypersensitivity to zinc sulphate,

small children under age 2 years.

naphazoline and other ingredients; dry eyes,

SIE: Transient burning sensation, occasional mydriasis, haedache, drowsiness & tachycardia. Cautions: Pregnency & lactation; use carefully

specially in keratoconjunctivits sicca (Sjogren's syndrome). occur for a short time after tise of the drops, but

long-term medication, if treatment longer than 2-

this does not affect the success of the treatment.

3 days is foreseen it should be prescribed

Precautions: Narrow angle glaucoma; the use of

monitored by a physician .

Dosage & appli: Apply I drop every 3 hours during the acute phase; maintenance, 1 drop 2-3 times daily. Children: 1-2 drops per day are sufficient for children. 10mi drop: 1 1 3.78 MRP

NAPHAZOLINE + PHENIRAMINE 102 :. NAPHCON-A Eye Drop AlconiGlobex

•

Each I ml contains active naphazoline hydrochloride 0.02S%

& pheniramine maleate

0.3% + benzalkonium chloride 0.0 1 % as

oculosan in pregnancy and during lactation has not been studied; patients wearing soft contact lenses may use oculosan eye drop if medication is given while the lenses are not worn.

Dosage: 1 drop in the conjunctival sac 3-4 times a day. Naphazoline nitrate BP O.OOS% (O.OSmg/ml)

&

zinc sulphate BP 0.02% (0.02mg/ l ml): Eye drop. 10ml drop: SO.OO IP

Mode of action: The combined preparation plays hydrochloride as a decongestant & pheniramine maleate as an antihistamine.

Ind: Ocular irritation and/or congestion; allergic or inflammatory ocular conditions.

CII: Hypersensitivity to one or more of the components of the preparation.

AIR: The following adverse reactions may occur pupillary dilation. increase in intraocular pressure, systemic effects due to absorption (i.e hypertension, cardiac irregularities, hyperglycemia).

Precautions: .Use with caution in elderly patients with severe cardiovascular disease including cardiac arrhythmias, patients with poorly controlled hypertension, patients with diabetes, specially those with a tendency toward diabetic ketoacidosis.

Warnings: Do not use in the presence of narrow angle glaucoma or in patients predisposed to narrow angle glaucoma. Patients under MAO inhibitors may experience a severe hypertensive crisis if given a sympathomimetic drug such as naphazoline hydrochloride. Use in infants and children may result in CNS depression leading to coma and marked reduction in body temprature.

Dosage & admin: 1 or 2 drops instilled in each eye every 3 to 4 hours or less frequently, as required to relieve symptoms, or as advised by the physician. To prevent contamination of the dropper tip and solution, care should be taken not to touch the eyelids or surrounding area


OXYPHENONIUM21.'O' .:. ANTRENEX Eye Drop Opso Saline I % eye drop. Ind: In cycloplegic refraction; treatment of Oxyphenonium bromide

synachiae; preoperative and postoperative mydriasis; treatment of malignant glaucoma.

CII; SIE; Cautions: Same as atropine eye drop. Dosage: Adult & Child- 1 drop as required. 1 0mi drop: 4 1 .S0 MRP

TROPICAMIDE21,33 TROPICAMIDE: Eye Drop & I % eye drop . Ind: Mydriatic & cycloplegic (with a rapid recovery of accommodation) for refraction.

&

pressure not known, In infants maintain pressure

zinc sulphate BP 0.02% (0.02mg/1 ml): Eye drop.

over lachrymal sac for I minute.

I Oml drop: SO.OO MRP

Adult & Child: 1-2 drpps at 1-5 min. intervals. If patient not examined within 30 min. an additional drop should be used.

preservative: Eye drop. a combined role, such as- naphazoline

Homatropine hydrobromide 2%: single dose eye drop.

CII: Narrow agnle glaucoma. Cautions: Use with care when intraocular

.:. NAZIN Eye drop Aristopharma.

Naphazoline nitrate BP O.OOS% (O.OSmg/ml)

10mi drop: 29.00 MRP

.:. HOMATROPINE Eye Drop Reman

Tropicamide 0.5%

:. NAPHALON Eye drop Reman

•

Homatropine hydrobromide 2%: single dose eye drop.

uveitis; treatment and prophylaxis of posterior

SIE: Mydriasis; slight burning sensation may

with children; the preparation is not intended for

&

.:. HOMATROPINE-OSL Eye Drop Opso Saline

ZINC SULPHATE + BORIC ACID :. Z-B EYE Drop Reman

•

Zinc sulphate O.SOgm, acid boric 4gm and

.:. DILATE Eye Drop Incepta & 1 .0%: eye drop .

Tropicamide O.S%

O.S% x Sml drop: 60.00 MRP

benzalkonium chloride/ lOoo c.c: eye drop

1 .0% x Sml drop: 76.00 MRP

Ind: Chronic inflammation of the eye, angular allergic conjunctivitis, blepharitis.

.:. MYDRIMIDE Eye Drop Reman Tropicamide O.S% & 1 .0%: eye drop.

Dosage: 1-2 drops 2 to 3 times daily.


1 0mi vial: 1 7. 1 1 MRP

1 .0% x Sml drop: 8S.00 MRP

.:. TROPICAM Eye Drop Aristopharma Tropicamide O.S% & 1 .0% eye drop.

MYDRIATICS & CYCLOPLEGICS


ATROPINE2 1 ,33

.:. TROPICAMIDE-OSL Eye Drop Opso Saline Tropicamide O.S% & 1 .0% eye. drop.

ATROPINE: Eye Drop

Atropine Sui ph. I % eye drop.

Ind: Mydriatic & cycloplegic for pre & post. operative use. Treatment of keratitis, iritis, cyclitis & refractive works in children CII: Narrow angle glaucoma. SIE & Cautions: It is less suitable because of its long duration of action; may precipitate glaucoma; contact dermatitis is not uncommon; a toxic systemic reaction to atropine may occur in the very young and the very old; in infants maintain pressure over lachrimal sac for. 1 min.

Dosage: Adult & Child: 1 drop as required. .:. HEMOMIN Eye Drop Nipa

Homatropine hydrobromide 2%: eye drop.

1 .0% x Sml drop: 8S.00 MRP

O.S% x Sml drop: SS.OO MRP O.S% x 10ml drop: 7S.00 MRP 1 .0% x Sml drop: 7S.OO MRP

.:. TROPICAMIN Eye Drop Nipa Tropicamide O.S% & 1 .0% eye drop. O.S% x Sml drop: SS.55 MRP 1 .0% x Sml drop: 7S.00 MRP

.:. TROPIDIL Eye Drop Popular

Tropicamide 1 .0% eye drop.

1 .0% x Sml drop: 8S.OO MRP

.:. TRUSIL Eye Drop Gaco Tropicamide O.S% & 1 .0% eye drop. O.S% x 5ml drop: 55.62 MRP O.S% x 10mi drop: 7S.86 MRP 1 .0% x Sml drop: 7S.86 MRP

QIMP-I5 (420)


TROPICAMIDE + PHENYLEPHRINE36.I 03

(Smg/ml) and phenylephrine hydrochloride S %

agent; therefore, caution should be exercised in

SOli drop: SO.OO MRP

patients using concomitant adrenergic

.:. TRUSIL-Plus Eye Drop Gaco

TROPICAMIDE + PHENYLEPHRINE: Eye drop Combination product of tropicamide O.S% (Smg/ml) and phenylephrine hydrochloride S%

Mode of action: This is a mydriatic combination. (antimuscarinic) agent, which is a competitive inhibitor of the action of acetylcholine having a rapid but shorter duration of effects, this causes paralysis of the sphincter muscle of the iris resulting in pupillary dilatation. The ciliary muscle is also paralyzed leading to loss of accommodation. Phenylephrine is a selective alpha I -agonist, which causes mydriasis without cycloplegia. It tends to reduce intraocular lesion by vasoconstrictor action.

Ind: As a mydriatic combination this product is indicated in some pre- and post-operative states

and for several ophthalmologic examinations like ophthalmoscopy, slit-lump examination, retinal photography, laser treatment, adjunct in the treatment of anterior uveitis. ]t also may be used in temporary lowering of intraocular pressure in glaucoma.

CII: Known hypersensitivity to any ingredient of the preparation; narrow angie glau� oma.

SfE: Ocular side effects include transient stinging

and raised intra-ocular pressure� on prolonged

administration local irritation, IlYperentia, edema and conjunctivitis may occur. Systemic effects include arrhythmias, hypeltension, and coronary artery spasm.

Precaution: Children and elderly; cardiovascular diseases, tachycardia, hypertension, diabetes.

Dosage & admin: Instil 1-2 drops in the eye(s) 15-20 minutes before examination, If examination is not conducted within 20-30 minutes, an additional drop may be placed in the eye(s) to prolong the effect. Drug inter: Phenylephrine may interact with systemically administered monoamino oxidase inhibitors (MAOls) .

glaucoma, betaxolol ophthalmic solution should

(Smg/m]) and phenylephrine hydrochloride S%

be used with a miotic and not alone.

(SOmg/ml): eye drop Sml drop: SO.OO MRP

.:. BETAXOL Eye Drop Aristopharma

Betaxolol hydrochloride BP equivalent to betaxolol 2.Smg/ml (i.e 0.2S% w/v) sterile

MYOTICS & GLAUCOMA DRUGS

ophthalmic solution: eye drop.

BETAXOLOL' 33

Betaxolol hydrochloride BP equivalent to

Sml drop: I SO.OO MRP

.:. BETOPTIC-S Eye Drop AlconlGlobex

betaxolol 2.Smg/ml (i.e 0.2S% w/v) sterile

BETAXOLOL: Eye Drop,


BetaxoJoi, a selective beta-adrenergic receptor

Sml drop: 279. 1 2 TP

blocking agent for topical administration into the

.:. OPTALOC Eye Drop Popular

eyes. It is available as betaxolol hydrochloride

Betaxolol hydrochloride BP equivalent to

BP equivalent to betaxolol 2.Smg/ml (i.e 0.2S%

betaxolol Smg/ml (i.e O.S% w/v) sterile

w/v)


& betaxolol Smg/ml (i.e O.S% w/v) sterile

ophthalmic solution or drop. Benzalkonium


chloride is present 0. 1 mg/ml as preservative.

Mode of action: Betaxolol is a selective beta adrenergic receptor blocking agent for topical administration into the eyes.

Ind: Betaxolol 0.5% eye drop is indicated in the· treatment of ocular hypertension and chronic open-angle glaucoma. May be used alone or in combination with other intraocular pressure lowering medication.

CII: Hypersensitivity to any component of this product. Betaxolol should not be used in patients with sinus bradycardia, atrioventricular block greater than first degree, cardiogenic shock, �r patients with a history of overt cardiac failure.

SfE: Ocular: Discomfort of sholt duration, occasional tearing has been reported. Rare instances of decreased corneal sensitivity, erythema, itching sensation, corneal punctuate staining, keratitis, edema and photophobia have been reported. Systemic: Systemic reactions following administration of betaxolol hydrochloride ophthalmic solution O.S% have been rarely reported. These include: Cardiovascular- bradycardia, heart block, congestive heart failure. Respiratory bronchospasm, respiratory failure.

.:. MYDRIMIDE Plus Eye Drop Reman

Precauitons: In patients with angle-closure

Combination product of tropic amide O.S%

glaucoma. the immediate treatment objective is to

(Smg/ml) and phenylephrine hydrochloride S%

re-open the angle by constriction of the pupil

(SOmg/ml): eye drop

with miotic agent. Betaxolol has no effect on the

Sml drop: SO.OO MRP

pupil; therefore, betaxolol O.S% should be used

.:. TROCANE Eye Drop Drug Inter,

with a miotic to reduce elevated intraocular

Combination product of tropicamide O.S%

psychotropic drug. In patients with angle-closure


(SOmg/ml ) : Eye drop In this. tropicamide is an anticholinergic

Drug inter: Betaxolol is an adrenergic blocking

(SOmg/ml): e y e drop

pressure in angle-closure glaucoma. Beta


adrenergic blocking agents shoud be administered

(SOmg/ml): eye drop

with caution in patients subjected to spontaneous

Sml drop: 6S.00 MRP

hypoglycemia or to diabetic patients as these

.:. TROPHEN Eye Drop Aristopharma

agents may mask the signs and symptoms of


acute hypoglycemia.

( Smg/ml) and phenylephrine hydrochloride S% (SOmgiml): eye drop

Pregnancy & lactation: There are no adequate & well controlled studies in pregnant women.

Sml drop: SO.OO MRP

Betaxolol dphthalmic solution should be used

.:. TROPICAMIDE Plus Eye Drop Opso Saline

justifies the potential risk. It is not known


whether betaxolol is excreted in human milk. The


risk of hypoglycemia

during pregnancy only if the potential benefit

& bradycardia in nursing

BRIMONIDINE42 BRIMONIDINE: Eye drop

Brimonidine tartrate is an alpha adrenergic

receptor agonist. It is available as brimonidine tartrate 0.2% eye drop, each ml of which contains brimonidine tartrate 2mg equivalent to brimonidine INN 1 .32mg.

Mode of action: Brimonidine tartrate has a peak ocular hypotensive effect occurring at two hours

post-dosing. Fluorophotometric studies in animals and humans suggest that brimonidine tartrate has a dual mechanism of action by reducing aqueous humor production and increasing uveoscleral outflow.

Ind: Brimonidine eye drop is indicated for lowering intraocular pressure in patients with open-angle glaucoma or ocular hypeltension.

CII: Brimonidine eye drop is contraindicated in

patients with hypersensitivity to brimonidine tartrate. It is also contraindicated in patients

receiving monoamine oxidase (MAO) inhibitor therapy.

SfE: Adverse events occurring in approximately 10-30% of the subjects, in descending order of incidence, included oral dryness, ocular hyperemia, burning and stinging, headache, blurring, foreign body sensation, fatigue/drowsiness, conjunctival follicles, ocular allergic reactions, and ocular pruritus. Events occurring in approximately 3-9% of the subjects, in descending order included corneal staining/erosion, photophobia, eyelid erythema, ocular pain, ocular dryness, tearing, upper respiratory symptoms, eyelid edema, conjunctival edema, dizziness, blepharitis, ocular irritation, gastrointestinal symptoms, asthenia, conjunctival blanching, abnormal vision and muscular pain. The following adverse reactions were reported in less than 3% of the patients: lid crusting, conjunctival hemorrhage, abnormal taste, insomnia, conjunctival discharge, depression, hypertension, anxiety, palpitations/arrhythmias,

(SOmg/ml): eye drop

infant has not been evaluated.

nasal' dryness and syncope.

Sml drop: 75.00 MRP

Dosage & admin: The usual dose is I drop of betaxolo I 0.25 % or 0.5 % eye drops in the affected eye(s) twice daily,

ophthalmic solution (0.2%) had minimal effect

.:. TROPlDIL Plus Eye Drop Popular

Combination product of tropicamide 0.8%

Precautions: Although brimonidine tartrate on blood pressure of patients in clinical studies,

QIMP-15 (421) caution should be exercised in treating patients

with severe cardiovascular disease. Brimonidine

should be used with caution in patients with

depression, cerebral or coronary insufficiency,

Raynaud's phenomenon, orthostatic hypotension or thromboangitis obliterans.

Pregnancy & lactation: There are no adequate and well-controlled studies in pregnant women.

In animal studies, brimonidine crossed the

placenta and entered into the fetal circulation to a limited extent. Brimonidine tartrate ophthalmic

solution should be used during pregnancy only if

the potential benefit to the mother justifies the potential risk to the fetus. It is not known

whether this drug is excreted in human milk; in

animal studies brimonidine tartrate was excreted

in breast milk. A decision should be made

whether to discontinue nursing or to discontinue

the drug, taking into account the importance of

the drug to the mother.

Dosage & admin: The recommended dose is one drop of brimonidine tartrate ophthalmic solution (0_2%) in the affected eye(s) three times daily, approximately 8 hours apart. Brimonidine tartrate ophthalmic solution may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure_ If more than one topical ophthalmic product is being used, the products should be administered at least 5 minutes apart_ Drug inter: Although specific drug interaction studies have not been conducted with

brimonidine ophthalmic solution, the possibility of an additive or potentiating effect with CNS

depressants (alcohol, barbiturates, opiates,

sedatives, or anesthetics) should be considered.

Alpha-agonists, as a class, may reduce pulse and

blood pressure. Caution in using concomitant

drugs such as beta-blockers (ophthalmic and

reverse mydriasis.

CII: Where pupilary constriction is undesirable; acute iritis

Adult & Child: 1 drop 4 to 6 times daily_ For Miosis: 1 drop of 1 % soln_ .:. ASIPlNE Eye Drop Asiatic

Pilocarpine hydrochloride 2% eye drop. 2% x 1 0mi drop: 80.00 MRP

.:. OPTACARPINE Eye Drop Popular

Pilocarpine hydrochloride 2% eye drop. 2% x . iOml drop: 1 30.00 MRP

.:. PILOCARPINE-OSL Eye Drop Opso Saline Pilocarpine hydrochloride 1 %, 2% & 4% drop.

glycosides is advised. Tricyclic antidepressants

have been reported to blunt the hypotensive

effect of systemic clonidine . It is not known whether the concurrent use of these agents with

brimonidine tartrate ophthalmic solution in

humans can lead to resulting interference with

the lOP lowering effect.

Brimonidine tartrate 0.2% solution, each ml of

which contains brimonidine tartrate 2mg

Dosage & appli: Adult: Initially one drop of 0.25% solution twice daily changing to 0.5% solution twice daily if requird. Child: Not recommended_ Drug inter: Calcium channel blockers,

cateCholamine-depleting drugs and beta-blocking agents may lead to hypotension andlor severe

bradycardia.

.:. ARISTOMOL Eye Drop Aristopharma

Timolol maleate O.SO% eye drop. 0.50% x 5101: 70.00 MRP

.:. ASINOL Eye Drop Asiatic

Timolol maleate 0.5% eye drop.

.:. PILO DROP Eye Drop Reman Pilocarpine hydrochloride 1 %, 2% & 4% eye

Timolol maleate O.S% eye drop.

I % x IOml drop: 50.92 MRP

Timolol maleate as ophthalmic gel preparation:

4% x l Oml drop: 1 28.00 MRP

drop.

2% x 1 0mi drop: 80.56 MRP

4% x I Oml drop: 1 39.76 MRP

.:. PILOMIN Eye Drop Nipa Pilocarpine hydrochloride 2% & 4% eye drop.

0.50% x 5ml: 67.00 MRP

.:. LOTENSIN Eye Drop ACI

Sml drop: 67.00 IP

.:. NYOLOL Eye Gel Novartis

eye gel drop.

Dosage & admin: Apply one drop once daily_

Sgm gel drop: 1 99.40 MRP

.:. OCUPRES Eye Drop Popular

2% x IOml drop: 1 30.00 MRP

Timolol maleate O.SO% eye drop.

TIMOLOL21.33.54

Timolol maleate O.SO% eye drop.

TlMOLOL: Eye Drop

Timolol maleat 0.2S%

4% x 1 0mi drop: 1 75.00 MRP

O.SO% x Sml: 60.00 MRP

.:. TEMLO Eye Drop Square

Timolol maleate 0.25% & 0.50% eye drop. Ind: Ocular hypel1ension; chronic open angle

glaucoma; including aphakia; secondary

glaucoma.

CII: Bronchial asthma, bronchospasm. history of brochial asthma or severe chronic obstructive

cardiac insufticiency, cardiogenic shock, severe atrio-ventricular block, Raynaud's phenomena, severe bradycardia (pulse rate < 4S-S0/min),

hypersensitivity to any component of the

fonnulation.

SIE: Timolol ophthalmic solution is generally well-tolerated. In clinical studies of timolol

O.SO% x 5ml: 70.00 MRP

.:. TIMODROP Eye Drop Reman & 0.50% Eye drop.

0.25% x 5ml: 46.86 MRP O.S% x Sml: 67.48 MRP

.:. TIMOLAT Eye Drop Ibn Sina & 0.50% eye drop.

Timolol maleate 0.2S%

0.25% x 5101: 45.00 MRP 0.50% x 5101: 70.00 MRP

.:. TIMOLOL OSL Eye Drop Opso Saline & 0.50% Eye drop.

Timolol male at 0.2S%

0.25% x Sml: 43.00 MRP O.S% x Sml: 62.75 MRP

.:. TIMOMIN Eye Drop Nipa

Timolol maleate O.S% eye drop. 5101 drop: 63.72 MRP

.:. TIMOPRESS Eye Drop Incepta & 0.50% Eye drop.

maleate, the adverse reactions reported were

Timolol maleat 0.25%

OClIlar- symptoms of ocular irritation, including

O.SO% x 5101: 70.00 MRP

mainly:

.:. BRIMO Eye Drop Popular

lactation in not recommended except for

compelling reasons.

1 % x IOml drop: 47.50 MRP ' 2% x IOml drop: 74.00 MRP

pulmonary disease, uncontrolled congestive

systemic), antihypertensives and/or cardiac


conjuctivitis, blepharitis, keratitis and corneal

equivalent to brimonidine INN 1 .32mg: eye drop

hypoesthesia;

.:. BRIMONIDINE Eye Drop Alcon/Globex

hypotension, syncope, hem1 block,

which contains brimonidine tartrate 2mg

congestive heart failure, palpitation, cardiac arrest;

0.25% x 5ml: 55.00 MRP

Cardiovascular- bradycardia, arrhythmia,

BRIMONIDINE + TIMOLOL 133

Brimonidine tartrate 0.2% solution, each ml of

cerebrovascular accident, cerebral ischemia,

BRIMONIDINE + TlMOLOL: Eye drop


Respiratory- bronchospasm (predominantly in

brimonidine is an alpha-adrenergic receptor

disease), respiratory failure, dyspnea;

inhibitor. This combined preparation is available

5ml drop: 50.00 MRP

5ml drop: 335.00 TP

.:. LOCULAR Eye Drop Square

Brimonidine tartrate 0.2% solution, each ml of which contains brimonidine tartrate 2mg


5ml drop: 80.00 MRP

patients with pre-existing bronchospastic

Syslemic- headache, asthenia, nausea, dizziness, depression, fatigue;

Pilocarpine, available as 0.5%, 1 %, 2%, 3%

4% solutions.

&

Ind: Chronic non-congestive glaucoma and to

&

timolol is a beta-adrenergic receptor

as sterile eye drop, each ml of which contains

brimonidine tartrate INN 2mg and timolol

maleate BP equivalent to timolol 5mg as active

urticaria.

preservative.

cardiac failure. Withdraw dlllg gradually if

indicated for the reduction of elevated intraocular

dry eyes occur.

ocular hypertension who are insufficiently

studied in human pregnancy or lactation.

CII: Hypersensitivity to any component of this

including localized and generalized rash and

systemic beta-blocker side effects e.g skin rash,

PILOCARPINE: Eye Drop

agonist

Bodv as a whole- hypersensitivity reactions,

Precautions: Bronchospastic disease; congestive

PILOCARPINE2 1 ,,1)

In this combined ophthalmic preparation

Pregnancy & lactation: Timolol has not been Therefore, administration during pregnancy or

ingredients and benzalkonium chloride 0. 1 mg as

Ind: This combined ophthalmic preparation is

pressure (lOP) in patients with glaucoma or responsive to topiCal beta-blockers.

medication. Patients receiving monoamine


oxidase (MAO) inhibitor therapy. Bronchospasm, bronchial asthma or severe chronic obstructive pulmonary disease. Sinus bradycardia, second or third degree atrioventricular block, cardiac failure or cardiogenic shock. SIE: Most commonly reported adverse reactions are conjunctival hyperaemia and burning sensation, pruritus, allergic conjunctivitis, conjunctival folliculosis, visual disturbance, blepharitis, epiphora, corneal erosion, superficial punctate keratitis, eye dryness, eye discharge, eye pain, eye irritation, foreign body sensation. Precautions: Like other topically applied ophthalmic agents, these may be absorbed systemically. No enhancement of the systemic absorption of the individual active substances has been observed. Due to the beta-adrenergic component timolol, the same types of cardiovascular and pulmonary ad'verse reactions as seen with systemic beta-blockers may occur. Caution should be exercised in treating patients with severe or unstable and uncontrolled cardiovascular disease. Pregnancy & hictation: There is no adequate ' data on the use of this preparation in pregnant women. Timolol is excreted in human milk and there is potential for serious adverse reactions from timolol in breast-fed infants. Therefore, a decision should be made whether to discontinue breast-feeding or to discontinue this eye drops, taking into account the importance of this eye drops to the mother. Dosage & admin: The recommended dose is one drop to the affected eye(s) twice daily. Drug inter: Specific drug interaction studies on this ophthalmic preparation have not been established. .:. BRIMOPRES Eye Drop Popular Each 011 eye drop contains brimonidine t3l1rate INN 2mg and timolol maleate BP equivalent to timolol 5mg as active ingredients and benzalkonium chloride 0. 1 mg as preservative. SOli drop: 1 1 0.00 MRP

LATANOPROST21 .60. I 02 LATANOPROST: Eye drop Latanoprost is a new and developed molecule for reduction of elevated intraocular pressure (lOP) and associated pain. It is a prostaglandin analogue, which increases uveoscleral outtlow. It is available as an ophthalmic solution in a concentration of 0.005% w/v (i.e 50mcg or 0.05mg/ml): eye drop. Ind: Reduction of elevated intraocular pressure (lOP) in patients with open-angle glaucoma (OAG) and ocular hypertension. CII: Known hypersensitivity to any component. Use of all contact lenses. SIE: Iris pigmentation and a slight foreign body sensation. Also mild conjunctival and moderate hyperaemia; transient punctate epithelial erosions, mostly without symptoms. Rarely, a skin rash of unknown aetiology and macular oedema. Precautions: Latanoprost may increase brown pigment within the iris leading to a gradual change in eye colour. This has predominantly been seen in patients with red coloured iris and

QIMP-15 (422)

may be permanent. Patients should be examined regularly and treatment to be discontinued if appropriate. Unilateral treatment can result in permanent heterochromia. Exercise caution in patients with severe or brittle asthma, inflammatory ocular conditions and other types of glaucoma, including OAG of pseudophakic patients. Pregnancy & lactation: Don't use in pregnancy. In lactation don't use or stop breast feeding. Dosage & admin: Adults including the elderly1 drop into the affected eye(s) once daily in the evening. Children- Not recommended. Drug inter: Definitive data are not available. .:. REMAPROST Eye Drop Reman Each I ml contains latanoprost INN 50mcg (i.e 0.005% w/v) and benzalkonium chloride 0.20mg: eye drop. 2.5ml drop: 495.00 MRP .:. XALATAN Eye Drop Pharmacia-Ptizerl Janata Each I ml contains lataooprost 50mcg (i.e 0.005% w/v) and benzalkonium chloride 0.20mg: eye drop. 2.5ml drop: 1 078.24 MRP

TRAVOPROST2 1.60. 102 TRAVOPROST: Eye drop Travoprost is a prostaglandin analogue, which increases uveoscleral outflow. h is available as an ophthalmic solution in a concentration of 0.004% w/v (i.e 40mcg or 0.04mg/ml): eye drop. Ind: Reduction of elevated intraocular pressure (lOP) in patients with open-angle glaucoma (OAG) and ocular hypertension. CII: Known hypersensitivity to any component. Use of all contact lenses. SIE: See under latanoprost; also headache, ocular pruritus, photophobia, & keratitis reported; rarely, hypotension, bradycardia, conjunctivitis, browache. Cautions: See under latanopros!. Dose: Apply I drop into the affected eyers) once daily, preferably in the evening. Child & adolescent under 18 years, not recommended. .:. AVATAN Eye Drop Aristopharma Travoprost 40mcglml (i.e 0.004% w/v) and benzalkonium chloride as excipient: eye·drop. 3ml drop: 470.00 MRP .:. TRAVAST Eye Drop Incepta Travoprost 40mcg/ml (i.e 0.004% w/v) and benzalkonium chloride as excipient: eye drop. 3ml drop: 470,00 MRP .:. TRAVATAN Eye Drop AlconiGlobex Travoprost 40mcg/ml (i.e 0.004% w/v) and benzalkonium chloride as excipient: eye drop. 2.5ml drop: 946.00 TP

DRUGS IN DRY EYES

HVPROMELLOSE2t .33 HYPROMELLOSE: Eye Drop Hypromellose 0.3% eye drop.

Ind: Tear deficiency (dry eyes). Use & appli: Adult & child, 2 drops 3 times daily. .:. ATIER Eye drop ACI Hypromellose 0.3% eye drop. I Oml drop: 65.00 fP .:. EYEFRESH Eye drop Opso Saline Hypromellose 0.3% eye drop. 1 0101 drop: 40.00 MRP .:. GLAMOR Eye drop Ibn Sina Hypromellose 0.3% in dextran 70: eye drop. 10mi drop: 80.00 IP .:. HYPRO Eye drop Nipa Hypromellose 0.3% in dextran 70: eye drop. 5ml drop: 60.00 MRP .:. LUBRic Eye drop Incepta Hypromellose 0.3% eye drop. 10mi drop: 65.00 MRP .:. OCUTEAR Eye drop Asiatic Hypromellose 0.3% eye drop. I Oml drop: 60.00 MRP .:. TEARSOL Eye drop Reman Hypromellose 0.3% eye drop: I Oml drop: 70.00 MRP .:. TEAR Eye drop Gaco Hypromellose 0.5% eye drop. 10011 drop: 60.00 MRP

POLYETHYLENE GLYCOL + PROPYLENE GLYCOU6 POLYETHYLENE GLYCOL + PROPYLENE GLYCOL: Eye Drop This combined preparation of polyethylene glycol & propylene glycol protects eyes from discomfort associated with dry eye so that the eyes feel moist and refreshed for a long period of time. This is available as eye drop, each 101 of which contains polyethylene glycol 400 USP 4mg & propylene glycol USP 3mg. Mode of action: The mechanism of action of pOlyethylene glycol & propylene glycol preparation is thought to be due to its unique gelling and lubricating system formulated to adjust to each user's individual tear pH. When the ingredients of this preparation combine with natural tears, a soft gel forms a network of protection over the eye surface. Since it promotes a healthy environment in eye surface. damaged surface cells of eye can repair more easily. Ind: This combined eye drop is indicated for the temporary relief of burning and irritation due to dryness of the eye. CII: It is contraindicated in patients with known sensitivity to any ingredient of this preparation. SIE: Generally well tolerated. This drop should not be used if allergic condition occurs to any ingredients of the product Precautions: Never touch tip of container with any surface to avoid contamination & replace cap after each use. Dosage & admin: Instill 1 drop 4 times daily in the affected eye(s) or as needed. .:. SYSTANE Eye drop AIconiGlobex Each ml of preparation contains- polyethylene glycol 400 USP 4mg & propylene glycol USP 3mg: eye drop. 5ml drop: 374.00 TP

QIMP-15 (423)


.:. SYSTEAR Eye drop Aristopharma Each ml of preparation contains- polyethylene glycol 400 USP 4mg & propylene glycol USP 3mg: eye drop. l Oml drop: ISO.OO MRP

.:. HYPOTEARS Plus Eye drop Novartis Each Iml of preparation contains- povidone SP SOmg (S% w/v), including benzalkonium chloride O.OSmg & other preservatives 10mi drop: 1 36.24 MRP

vitamin A palmitate 10mg/gm ( 1 000 IU) & carbomer 980 (carbopollpolyacrylic acid) 3.Smglgm: ophthalmic gel · preparation. Sgm gel pack: 1 00.00 MRP

ELECTROLYTES + POVIDONE PREPNS.36,54

.:. PROTEAR Eye drop Aristopharma Each I ml of preparation contains- povidone BP SOmg (S% w/v), including benzalkonium chloride O.OSmg & other preservatives 10mi drop: 80.00 MRP

OTHER PREPNS.36.102

POVIDONE S % : Eye Drop Povidone, a synthetic polymer consisting essentially of linear l -vinyl-2-pyrolidinone groups, is included in the anificial tears preparation & used effectively in the management of dry eyes. Comp: Each I ml of preparation contains povidone (polyvidone) BP SOmg (S% w/v), boric acid 2.0mg, sodium chloride S.4mg, sodium lactate 0.2mg, potassium chloride l .Smg, calcium chloride O. I Smg, magnesium chloride 0.2mg, water for solution qs tolm!. Preservative benzalkonium chloride O.OSmg. Ind: Povidone eye drop preparation is used for the symptomatic treatment of dry eye conditions including keratoconjunctivitis sicca. It is also given as a substitute of tear fluid in case of unstable tear film or insufficient moistening of the eye surface. CII: In patients with known hypersensitivity to any ingredient of the product. S/E: Occasionally mild, transient burning or sticky sensation and very rarely irritation or hypersensitivity reactions reponed. Blurred vision after application may occur. Precautions & warnings: Patients who experience blurred vision after application of the product should not drive or use machinery until their vision has cleared. Contact lenses should not be worn during instillation of the drops. After instillation there should be an interval of at least 30 minutes before reinsenion of contact lenses. Pregnancy & lactation: There is no experience regarding the safety of the povidone eye drops in human pregnancy or lactation. Administration during pregnancy and lactation is therefore not recommended, except for compelling reasons. Dosage & admin: 1 drop 4 times daily or as required, depending upon the severity of the disease to be instilled into the conjunctival sac, Close the bottle immediately after use, Do not use for longer than one month after first opening. Drug inter: In case of any additional local ocular treatment e.g glaucoma therapy there should be an application interval of at least S minutes between the two medications. Povidone always should be the last medication instilled. Incompatibiiities: High concentration of sodium sulphate in cold and of sodium chloride in warm conditions can result in precipitation of povidone. Depending on the ionic strength of the solution, methylparaben & propylparaben easily form complexes with povidone. .:. ARTEAR Eye drop Popular Each 1m! of preparation contains- povidone BP SOmg (S% w/v), including benzalkonium chloride O.OSmg & other preservatives 10mi drop: 80.00 MRP

VITAMIN A PALMITATE + CARBOMER54,103 VITAMIN A PALMITATE + CARBOMER: Eye gel This is a combined ophthalmic preparation of vitamin A palmitate l Omglgm ( 1000 IU) & carbomer 980 (carbopollpolyacrylic acid) 3.Smglgm: ophthalmic gel preparation. Mode of actions: This combined ophthalmic gel preparation is a new generation anificial tears. In this preparation, gel is a viscous aqueous solution based on carbomer 980. After topical application, gel spreads rapidly over the conjunctiva and cornea fonning a lubricating and protective film with a prolonged corneal ontact time. Tear film stability is maintained for up to 6 hours. Ind: Substitute of tear fluid for management of dry eye conditions including keratoconjunctivitis sicca and for unstable tear film or insufficient moistening of the cornea. CII: Known hypersensitivity to any component of the gel. S/E: Occasionally a transient burning sensation or sticky lids and/or blurred vision shonly after instillation. Very rarely hypersensitivity reactions. Precautions & warnings: Contact lenses should be removed before instillation and reinsened no sooner than 30 minutes after application. Patients . experiencing blurred vision after application of hypotears gel should not drive or use machinery until their vision has cleared. Pregnancy & lactation: There are no controlled studies regarding the safety of this gel preparation in human pregnancy and lactation. Therefore, this is only indicated if the therapeutic benefit outweighs the potential risk to the fetus. Dosage & admin: Adults and children: 3-4 times per day 1 drop or as required, depending on the severity of the case, Hold the tube vertically & apply 1 drop into the conjuctival sac, Close the tube immediately after use. Do not use for longer than one month after opening, Drug inter: None known to date. If additional ophthalmic medication is used there should be an application interval of at least S minutes between two medications. This combined gel preparation should always be the last medication instilled. .:. HYPOTEARS Eye gel Novartis This is a combined ophthalmic preparation of vitamin A palmitate l Omglgm ( 1 000 IU) & carbomer 980 (carbopollpolyacrylic acid) 3.5mglgm: ophthalmic gel preparation. 10gm gel pack: IS8.74 MRP

.:. TEARGEL Ophthalmic Gel Reman This is a combined ophthalmic preparation of

.:. CYPORIN Eye drop Aristopharma36 Cyclosporine USP O.OS% w/v: Eye drop Cyclosporine is a topical immunomodulator with anti-inflammatory effects. Mode of action: Cyclosporine is an immunosuppressive agent when administered systemically. In patients whose tear production is presumed to be suppressed due to ocular inflammation associated with keratoconjunctivitis sica, topical cyclosporine is thought to act as a panial immunomodu"tator. Ind: Cyclosporine eye drop is indicated to increase tear production in patients whose tear production is presumed to be suppressed due to ocular inflammation associated with dry eye syndrome (keratoconjunctivitis sicca): . CII: Cyclosporine eye drop is contraindicated in patients with active ocular infections and in patitnts with known or suspected hypersensitivity to any of the ingredients in the formulation. S/E: The �ost common adverse effect was ocular burning. Other effects reponed included conjunctival hyperemia, discharge, epiphora, eye pain, foreign body sensation, pruritus, stinging, and visual disturbances (most often blurring). Precautions: Cyclosporine drop should not be administered while wearing contact lenses. Patients with decreased tear production typically should not wear contact lenses. If contact lenses are worn, they should be removed prior to the administration of this formulation. Lenses may be reinsened IS minutes following administration of cyclosporine eye drop. Pregnancy & lactation: There are no adequate and well-controlled studies of cyclosporine ophthalmic emulsion in pregnant women. It should be administered to pregnant women if clearly needed. Cyclosporine is known to be excreted in human milk following systemic administration, but excretion in human milk after topical treatment has riot been investigated. Although blood concentrations are undetectable after topical administration of cyclosporine, caution should be exercised when cyclosporine is administered to a nursing woman. Dosage & admin: One drop to be instilled twice a day in each eye approximately 12 hours apart. Cyclosporine drop can be used concomitantly with artificial tears, allowing a IS-minute interval between products. Paediatric use: The safety and efficacy of cyclosporine eye drop have not been established in paediatric patients below the age of 16. But clinical study shows that cyclosporine eye drop is safe for children above 1 year of age. Sml drop: 200.00 MRP .:. TEARS NATURALE Eye Drop AlconlGlobex I 02 Description & mode of action: Tears naturale is

QIMP-15 (424)


a sterile, soothing solution for use as an artificial

Ind: This ocular antioxidant fonnulation is

tear and lubricant in relief of symptoms due to

indicated for age-related eye diseases and also

E 30mg, lutein 6mg, copper 2mg and zinc ISmg.

dry eye syndromes. This ophthalmic solution

provides nutritional support for the eyes. Besides,

20's pack: 160.00 IP

contains 'Duasorb', a water soluble polymeric

this fonnulation also supplements essential

system which combines with the existing tears of

antioxidant vitamins, minerals, and lutein in the

the eye to promote corneal wetting. This also

human body mechanisms.

provides extended retention time in the eye even

CII: Known hypersensitivity to any of the

though it is not a highly viscous solution. It

ingredients.

mimics the action of conjunctival mueus.

SIE: Generally well tolerated. However, a few

Ind: Indicated for use as an artificial tear and

allergic reactions may be seen. Diarrhoea and

lubricant in relief of symptoms due to dry eye syndromes.

Caution: To avoid contamination, do not touch dropper tip to any surface. If irritation persists, discontinue use and consult physician.

Dosage & admin: Instill 1 or 2 drops as frequently as required to relieve eye irritation symptoms or as directed by the physician. I Sml drop: I I S.OO TP

ANTIOXIDANT VITAMINS & MINERALS FOR EYE HEALTH26,42, 133

ANTIOXIDANT VITAMINS + MINERALS

other gastrointestinal disturbances may occur.

Precautions: Vitamin C should be given with care to patients with hyperoxaluria. In patients taldng oral anticoagulants or oestrogens, vitamin E should be given carefully because it has been found to antagonize the effects of vitamin K leading to an increase in blood clotting time in these patients.

Pregnancy & lactation: Recommended. Dosage & admin: One capsule daily; in more severe cases, 2 capsules a day may be given or as advised by the physician_ Drug inter: No such drug interactions have been reported.

.:. AZECOL Cap. Incepta This is a special preparation of ocular antioxidant vitamins with lutein and minerals, available as capsule (soft gelatin). Each capsule contains- vitamin C 60mg, vitamin E 30mg, lutein 6mg, copper 2mg and zinc I Smg.

ANTIOXIDANT VITAMINS + MINERALS: Capsule

28's pack: 224.00 MRP

This is a special preparation of ocular antioxidant

This is a special preparation of ocular

vitamins with lutein and minerals, available as

antioxidant vitamins with lutein and minerals,

DRUGS FOR LENS OPACIFICATION

ANTIOXIDANTS + CO ENZYMES ,03.133 ANTIOXIDANTS + CO-ENZYMES PREPNS: Eye Drop This is a specialised combined ophthalmic preparation containing antioxidants

& co

enzymes, viz: adenosine, cytochrome C, sodium succinate, and nicotinamide for topical administration to the eyes.

Comp: Each ml eye drop contains- adenosine BP 2mg, cytochrome C O.Smg, sodium succinate 0.6mg and nicotinamide BP I Omg/20mg. Thiomersal O.OSmglml is added as preservative.

Mode of action: Biological energy is necessary to maintain the transparency & viability of the lens. Primarily it is regulated by energy dependent mechanisms. ATP & pyridine nucleotides have a central role in energy dependent metabolic reactions of the lens. But, during the aging process of any individual, synthesis of ATP, nucleic acids,

&

NADPHlNAD+ are decreased, resulting in

.:. EYEVI Cap. Square

capsule.

available as capsule (soft gelatin).

Comp: Each capsule contains: Vitamin C ·USP

Each capsule contains- vitamin C 60mg, vitamin

60mg, Vitamin E USP 30mg, Lutein 6mg,


Copper (as cupric oxide) 2mg

30's pack: 240.00 MRP

& Zinc (as zinc


reduced energy-generating metabolism of the lens. Medical treatment with the above product seems well able to provide back up to the aging lens

& improve lens functional energy producing

state. Adenosine, itself a precursor of ATP. Cytochrome C, an ideal antioxidant

oxide) ISmg.

.:. I-GOLD Cap. Aristopharma

Mode of action: Vitamin C is highly


concentrated in the lens compared to blood. A


long-term vitamin C supplementation ( 1 0 years


+) has been associated with reduced risk of


cataract It has important role in harmful free

E 30mg, lutein 6mg, copper 2mg

radicals scavenging activity.

30's pack: 240.00 MRP

& zinc I Smg.

& involved in oxidative

phosphorylation for producing ATP from ADP. Sodium succinate promotes production of ATP. Nicotinamide involved in the process of creating ATP. Thus, all these play role in backing up the aging lens

& improving lens functional energy

producing state.

Ind: This eye drop is used for the treatment of

High concentrations of serum vitamin E have

.:. OCUVIT Cap. Asiatic

been associated with reduced risk of cataract

This is a spedal preparation of ocular

(exact mechanism of action is not still


established). As an antioxidant vitamin, it also


plays an important role in harmful free radicals

Each capsule contai"s- vitamin C 60mg, vitamin

scavenging activity.


Lutein is a carotenoid specially concentrated in

24's pack: 192.00 MRP

& zinc I Smg.

lens opacification.

CII: Patients with known hypersensitivity to any ingredient of the product.

SIE: Like any active ingredient, this drug may cause inore or less discomfort in some patients. If you feel any discomfort, infonn your consultant.

Precautions: In case of concomitant treatment

macula. This carotenoid could protect the macula

.:. OPTAVIT Cap. Popular

from oxidative or light damage. Although exact


mechanism of action is not clear but it has found


that high levels of dietary lutein is associated


with relatively lower risk of AMD (age-related


macular degeneration: a condition where fine


visual acuity is lost).

28's pack: 224.00 MRP

& zinc ISmg.

with another ophthalmic solution, wait I S minutes between each instillation.

Pregnancy & lactation: As a general rule, it is recommended to ask the consultant for advice before using this medicine for a pregnant or nursing mother.

Dosage & admin: 1 drop twice daily. Drug inter: In order to avoid any interaction

Zinc is an eassential trace element involved in

.:. TIOXIL Cap. ACI

many enzyme systems. Symptoins of less severe


deficiency include distorted or absent perception


of taste, smell and poor wound healing. Severe

capsule (soft gelatin).

deficiency causes sldn lesion, alopecia, diarrhoea,


increased susceptibility to infection and failure to


.:. CATRIX Eye Drop Incepta

thrive in children.

30's pack: 240.00 MRP

Mediphakol is a sterile combined ophthalmic

between different medical products, should infonn the consultant of any other ongoing treatment in particular with other eye drops.

Copper plays important role in growth, skeletal

.:. VrvIS Cap. Beximeo

integrity, and development of nervous system. As


solution containing antioxidants & co-enzymes. Comp: Each ml drop contains- adenosine BP

a part of various enzymes, it takes part in


2mg, cytochrome C O.Smg, sodium succinate

numerous metabolic conversions.

capsule (soft gelatin).

0.6mg and nicotinamide BP 20mg.

QIMP-15 (425)

Sml drop: 1 20.00 MRP

.:. MEDIPHAKOL Eye Drop Reman Mediphakol is a sterile combined ophthalmic solution containing antioxidants & co-enzymes. Comp: Each ml drop contains- adenosine BP 2mg, cytochrome C O.Smg,. sodium succinate 0.6mg and nicotinamide BP 20mg. Sml drop: 1 20.00 MRP •:. PHACOVIT Eye Drop Aristopharma Mediphakol is a sterile combined ophthalmic solution containing antioxidants & co-enzymes. Comp: Each ml drop contains- adenosine BP 2mg, cytochrome C O.5mg, sodium succinate 0.6mg and nicotinamide BP 20mg. Sm! drop: 1 20.00 MRP

.:. VITAFOL Eye Drop Popular Vitafol is a sterile combined ophthalmic solution containing antioxidants & co-enzymes. Comp: Each ml drop contains- adenosine BP 2mg, cytochrome C O.Smg, sodium succinate 0.6mg and nicotinamide BP 10mg. Thiomersal O.OSmg/m! is added as preservative. Sml drop: 1 20.00 MRP

TREATMENT FOR AGE· RELETED MACULAR DEGENERATION (AMD)

RANIBIZUMAB54 .:. LUCENTIS Inj. Novartis Each vial contains 3.0mg of ranibizumab in 0.3ml solution: injection. Ind: Treatment of neovascular (wet) age-related macular degeneration (AMD). Dosage & admin: The recommended dose is O.Smg (O.OSml). Treatment initiated with a loading phase of one injection per month for 3 consecutive months followed by a maintenance phase in which patients should be monitored for visual acuity on a monthly basis. The interval between two doses should not be shoner than 1 month. Lucentis must be administered by a qualified ophthalmologist using aseptic techniques. Broad-spectrum topical microbicide and anaesthetic should be administered prior to the injection. The patient should be instructed to self-administer antimicrobial drops four times daily for 3 days before and after each injection. Not recommended in children and adolescents. CII: Hypersensitivity to ranibizumab or to any of the excipients, patients with active or suspected ocular or periocular infections, patients with active intraocular inflammation. Precautions & warnings: Intravitreous injections have been associated with endophthalmitis, intraocular inflammation, rhegmatogenous retinal detachment, retinal tear and iatrogenic traumatic cataract. Therefore, proper aseptic injection techniques must be used. Patients should be monitored during the week following the injection to pennit early treatment if an infection occurs. Intraocular pressure and the perfusion of the optic nerve head must be monitored and managed appropriately. As with all therapeutic proteins, there is a potential for immunogenicity with Lucentis. Following treatment patients may develop transient visual

disturbances that may interfere with their ability to drive or use machines. Patients should not drive or use machines as long as these symptoms persist. Pregnancy & lactation: Should not be used during pregnancy unless clearly necessary; use of effective contraception recommended for women of childbearing potential; breast-feeding not recommended . Drug inter: No fonnal interaction studies have been performed. AIR: Very common adverse reactions are conjunctival haemorrhage, eye pain, vitreous floaters, retinal haemorrhage, intraocular pressure increased, vitreous detachment, intraocular inflammation, eye initation, cataract, foreign body sensation in eyes, visual disturbance, blepharitis, subretinal fibrosis, ocular hyperaemia, visual acuity blurred/decreased, dry eye, vitritis. Common adverse reactions are ocular discomfort, conjunctival hyperaemia, posterior capsule opacification, retinal exudates, injection site reactions, lacrimation increased, eye pruritis, conjunctivitis, maculopathy, detachment of the retinal pigment epithelium; headache. Uncommon adverse reactions are- retinal degeneration, iritis, iridocyclitis, punctate keratitis, keratopathy, dellen, corneal striae, retinal disorder, vitreous disorder, photophobia, cataract nuclear, anterior chamber flare, corneal abrasion, angle closure glaucoma, vitreous haemorrhage, uveitis, endophthalmitis, retinal detachment, retinal tear, eye haemorrhage, eyelid oedema, eyelid irritation, blindness, corneal oedema, hypopyon. Rare but serious adverse reactions related to intravitreal injections included endophthalmitis, rhegmatogenous retinal detachment, retinal tear and iatrogenic traumatic cataract. Note: Before prescribing, please read full prescribing information. 0.3m! (3.0mg) vial x I 's pack: 90033.6S MRP

VERTEPORFIN54 .:. VISUDYNE Inj. Novartis Veneporfin ISmgivial: i.v injection. Veneporfin (visudyne) injection is supplied in a single-use glass vial with a gray bromobutyl stopper and aluminium flip-off cap. It contains a lyophilized dark green cake with ISmg veneporfin. The product is intended for i.v injection only. Verteporfin is a I: I mixture of two regioisomers, the molecular . formula is C41 H42

N40s.

Mode of action: Veneporfin is a light-activated drug used in photodynamic therapy. This verteporfin photOdynamic therapy is a two-stage process requiring- administration of verteporfin for injection & administration of nonthermal red light. Veneporfin is transponed in the ·plasma primarily by lipoproteins. Once veneporfm is activated by light in the presence of oxygen, highly reactive, shon-lived singlet oxygen & reactive oxygen radicals are generated. Light activation of veneporfin results in local damage to neovascular endothelium, resulting in vessel occlusion. Damaged endothelium is known to release procoagulant & vasoactive factors through the lipo-oxygenase (leukotriene) & cyclo-oxygenase


(eicosanoids such as thromboxane) pathways, resulting in platelet aggregation, fibrin clot formation and vasoconstriction. Verteporfin appears to somewhat preferentially accumulate in neovasculature, including choroidal neovasculature. However, animal models indicate that the drug is also present in the retina. Therefore, there may be collateral damage to retinal structures following photoactivation including tlie retinal pigmented epithelium and outer nuclear layer of the retina. The temporary occlusion of choroidal neovascularization (CNV) following verteporfin therapy has been confirmed in humans by fluorescein angiography.

Ind: Veneporfin therapy is indicated for the treatment of patients with predominantly classic subfoveal choroidal neovascularization due to age related macular degeneration (AMD), pathologic myopia, or presumed ocular histoplasmosis. There is insufficient evidence to indicate verteporfin for the treatment of predominantly occult subfoveal choroidal neovascularization. CII: Veneporfin injection is contraindicated for patients with porphyria or a known hypersensitivity to any component of this preparation. AIR: Severe chest pain, vasovagal & hypersensitivity reactions have been reported. Vasovagal & hypersensitivity reactions on rare occasions can be severe. These may include syncope, sweating, dizziness, rash, dyspnea, flushing & changes in blood pressure & hean rate. General symptoms can include headache, malaise, urticaria & pruritus. The most frequently reponed adverse events to veneporfin are injection site reactions (including pain, edema, inflammation, extravasation, rashes, hemorrhage & discoloralion) & visual disturbances (including blurred vision, flashes of light, decreased visual acuity & visual field defects, including scotoma). These events occurred in approximately J 0%-30% of patients. For more infonnation, see manufacturer's package insert.

Precautions & warnings: General: Following injection with verteporfin (visudyne), care should be taken to avoid exposure of skin or eyes to direct sunlight or bright indoor light for S days. [I' emergency surgery is necessary within 48 hours after treatment, as much of the internal tissue as possible should be protected from intense light.. Standard precautions should be taken durng infusion of verteporfin injection to avoid extravasation. Examples of standard precautions include, (but are not limited to): I. A free-flowing I. V line should be established before staning veneporfin infusion & the line should be carefully monitored. 2. Due to the possible fragility of vein walls of some elderly patients, it is strongly recommended that the largest arm vein possible, preferably antecubital, be used for injection. 3. Small veins in the back of the hand should be avoided. Extravasation of verteporfin, specially if the affected area is exposed to light, can cause severe pain, inflammation, swelling or discoloration at the injection site. If extravasation occurs, the infusion should be stopped immediately. The extravasation area


must be thoroughly protected from direct light until swelling and discoloration have faded in order to prevent the occurrence of a local burn, which could be severe. Cold compresses should be applied to the injection site. Oral medications for pain relief may be administered. Verteporfin therapy should be considered carefully in patients with moderate to severe hepatic impairment or biliary obstruction since there is no clinical experience with verteportin in such patients. Patients who experience severe decrease of vision of =4 lines within 1 week after treatment shoulld not be retreated, at least until their vision completely recovers to pretreatment levels & the potential benefits and risks of subsequent treatment are carefully considered by the treating physician. Use of incompatible lasers that do not provide the required characteristics of light for the photoactiva tion of vertepornn could result in incomplete treatment due to partial photoacti vation of verteporfin. overtreatment due to overactivation of verteportin, or damage to surrounding normal tissue.

Pregnancy & lactation: There are no adequate & well-controlled studies in pregnant woman. So, verteporfin should be used during pregnancy only if the benefit justifies the potential risk to the fetus. Because of the potential for serious adverse reactions in nursing infants from verteporfin, a decision should be made whether to discontinue nursing or postpone treatment, taking into account the importance of the .drug to the mother. Dosage & admin: A course of 'verteportin for injection' therapy consists of two-step process requiring administration of both drug & light. The lirst step is the i.v infusion of verteporlin. The second step is the activation of verteporlin with light from a nonthermal diode laser. The physician should reevaluate the patients every 3 months & if choroidal neovascular leakage is detected on fluorescein angiography, therapy should be repeated. Lesion size determination: The greatest linear dimension (GLD) of the lesion is estimated by fluorescein angiography and color fundus photography. All classic & occult CNV, blood andlor blocked fluorescence, & any serous detachments of the retinal pigment epithelium should be included for this measurement. Fundus cameras with magnification within the ange of 2.4-2.6 x are recommended. The GLD of the lesion on the fluorescein angiogram must be corrected for the magnilication of the fundus camera to obtain the GLD of the lesion on the retina. Spot size determination: The size of the spot to be treated should be 1000 microns larger than the GLD of the lesion on the retina to allow a 500 micron border, ensuring full coverage of the lesion. The maximum spot size used in the clinical trials was 6400 microns. The nasal edge of the treatment spot must be positioned at least 200 microns from the temporal edge of the optic disc, even if this will result in lack of photoactivation of CNV within 200 microns of the optic nerve. VerteporJin administration: Reconstitute each

QIMP-15 (426)

vial of verteporlin with 7ml of sterile water for injection to provide 7.5ml, containing 2mglm!. Reconstituted verteportin must be protected from light & used within 4 hours. It is recommended that reconstituted verteporlin be inspected visually for particulate matter & discoloration prior to administration. Reconstituted verteportin is an opaque dark green solution. Verteporron may precipitate in saline solutions. Do not use normal saline or other parenteral solutions. Do not mix verteporron in the same solution with other drugs. The volume of reconstituted verteporron required to achieve the desired dose of 6mglm2 body surface area is withdrawn from the vial and diluted with 5 % dextrose for injection to a total infusion volume of 30m!. After dilution, protect from light & use within a maximum of 4 hours. The full infusion volume is administered i. v over 10 minutes at a rate of 3ml (45 drops)/minute, using an appropriate syringe pump & in-line filter. The clinical studies were conducted using a standard infusion line filter of 1.2 microns. Precautions should be taken to prevent extravasation at the injection site. If extravasation occurs, protect the site from light. Light administration: Initiate 689nm wavelength laser light delivery to the patient 15 minutes after the start of the 10-minute infusion with verteportin. Photoactivation of verteporlin is controlled by the total light dose delivered. In the treatment of choroidal neovascularization, the recommended light dose is 50 J/cm2 of neovascular lesion administered at an intensity of 600mW/cm2• This dose is administered over 83 seconds. Light dose, light intensity, ophthalmic lens magnilication factor & zoom lens setting are important parameters for the appropriate delivery of light to the predeter mined treatment spot. Follow the laser system manuals for procedure setup & operation. Drug inter: See manufacturer's package insert. Note: For further information, please consult manufacturer's literature. 1 5mg (in single-use glass) vial: 1 , 2 1 ,780.49 MRP

OCULAR PERI-OPERATIVE DRUGS

HYDROXYPROPYL METHYLCELLULOSE 1 33 HYDROXYPROPYL METHYLCELLULOSE: Gel Preparation Hydroxypropyl methylcellulose is an isotonic, non-inflammatory viscoelastic solution. It is available as·a highly purified, clear and sterile ophthalmic gel, each ml of which contains hydroxypropyl methylcellulose USP 20mg. Mode of action: Hydroxypropyl methylcellulose maintains a deep anterior chamber during anterior segment surgery and thereby allows for more efficient manipulation with less trauma to the corneal endothelium and other ocular tissues. The viscoelasticity of hydroxypropyl

methylcellulose helps the vitreous face to be pushed back, thus preventing formation of a postoperative flat chamber. Ind: Hydroxypropyl methylcellulose is indicated for use as an ophthalmic surgical aid during surgical procedures involving the anterior chamber of the eye, including extraction of cataract and insertion of intraocular lenses. CII: Patients hypersensitive to any component of this product. S/E: Hydroxypropyl methylcellulose is extremely well tolerated after injection into the human eye. A transient rise in intraocular pressure post operatively may occur. Rarely, post-operative inflammatory reactions (iritis, hypopyon) as well as incidece of corneal edema and corneal decompensation may occur. Precautions: Precautions are limited to those normally associated with the ophthalmic surgical procedure being performed. There may be transient increased intraocular pressure following surgery because of pre-existing glaucoma or due to the surgery itself. For these reasons, the following precautions should be considered: Hydroxypropyl methylcellulose should be removed from the anterior chamber at the end of surgery. If the post-operative intraocular pressure increases above expected values, appropriate therapy should be administered. Dosage & admin: Cataract surgery and IOL implantation. For cataract surgery and intraocular lens implantation, hydroxypropyl methylcellulose ophthalmic solution should be carefully injected into the anterior chamber prior to capsulotomy using standard aseptic techniques. Hydroxypropyl methylcellulose may be injected into the chamber prior to or following removal of the crystalline lens. Instillation of hydroxypropyl methylcellulose prior to lens removal will provide protection to the corneal endothelium from possible damage due to surgical instrumentation during cataract surgery. Hydroxypropyl methylcellulose may also be used to coat an intraocular lens prior to implantation as well as the tips of surgical instruments. Additional hydroxypropyl methylcellulose may be injected during anterior segment surgery to fully maintain the chamber or replace any volume lost during the surgical procedure. At the end of the surgical procedure it is recommended that hydroxypropyl methylcellulose be removed from the eye as completely as possible by irrigation andlor aspiration. Storage: Store in a cool and dry place. Protect from light and freezing.

.:. OCUGEL Eye Soln. Aristopharma Each mI of ocugel ophthalmic solution contains hydroxypropyl methylcellulose USP 20mg (i.e 2%): eye drop. 3ml eye drop: 1 20.00 MRP .:. OPTAGEL Oph. Soln. Popular Each ml of optagel ophthalmic solution contains hydroxypropyl methylceUulose USP 20mg (i.e 2%): eye drop. 3ml in syringe: 120.00 MRP 5ml in glass vial: 1 20.00 MRP

QIMP-lS (427)


SALINE IRRIGATION SOLUTION))

are added to the product.

Precautions & warning: Even invisible damage

4ml drop: 33 .50 MRP

.:. NORSOL Eye Lotion Opso Saline21.IOI

result contamination. Do not use if leak found on

Sodium chloride 0.9% solution (normal saline)

squeezing, or contents not clear.

.:. NOVOCAINE Eye Drop Opsosaline

Ind: Irrigation, including first-aid removal of

Not for intravenous use.

harmful substances; intra-ocular or topical

Dosage: As directed by the surgeon or physician.

to the bottle caused during storage or transit may

For further information, please consult

irrigation during surgical proce-dures.

Note:

Use: As required.


25ml ampoule: 1 2.50 MRP


:. OPSO-RINSE Irrigating Soln. Opso Saline 'Ol

•

Opso-rinse is a sterile, balanced salt solution for peri-operative ophthalmic irrigation.

Comp: Each 1 00ml of solution contains sodium

chloride BP 0.490gm, potassium chloride BP 0.075gm, calcium chloride BP 0.04Sgm, magnesium chloride BP 0.030gm, sodium acetate

DIAGNOSTICS & PREPNS. FOR OPHTHALMIC EXAM2 1 .33

Adult & child: 1 or more drops as required. 10mi drop: 7S.S9 MRP

Oxybuprocaline hydrochloride 0.4% eye drop.

Ind: Surface anaesthesia of cornea & conjunctiva for ophthalmic procedures.

cn:

Proven sensitivity to the active ingredieill

oxybuprocaine.

SIE: Occasionally transient hyperaemia observed. Adult & child: 1 or more drops as required. I Oml drop: 42.00 MRP

.:. OXYCAINE Eye Drop Reman

Oxybuprocaine hydrochloride 0.4% eye drop.

Ind: Surface anaesthesia of cornea & conjunctiva for ophthalmic procedures.

.:. FLUROCINE Eye Drop Reman

ell:

Proven sensitivity to the active ingredient

BP 0.390gm, and sodium citrate BP 0 . 170gm.

Fluorescein sodium 2% eye drop

oxybuprocaine.

aid removal of harmful substances from the eye.

detection of corneal lesions

SIE: Occasionally transient hyperaemia observed. Adult & child: 1 or more drops as required

foreign bodies.

I Oml drop: 42.54 MRP

Ind: Peri-operative ophthalmic ilTigation; first

cn:

Damage of tissue could result if other drugs

Ind: Diagnostic stain for ophthalmic procedure; &

SIE: High incidence of sensitivity reactions;

ototoxicity.

Precaution: Perforated ear drum: avoid prolonged use.

Adult& child: 2 to 4 drops 2 or 3 times daily. .:. CHLORAMEX EIE Drop Renata

Chloramphenicol 0.5% eye/ear drop. 10ml bot: 25.29 MRP

:. CHLORPHEN Ear Drop Nipa

•

DRUGS ACTING ON EAR, NOSE & OROPHARYNX Drugs discussed in this chapter include:

\. Aural Preparations

a) Anti-infective preparations b) Steroid & steroid/antibotic combined preparations. 2. Nasal Preparations a) Antihistamine preparations b) Anti-Cholinergic preparations c) Mast cell stabilizer d) Conbind nasal preparations e) Nasal steroid preparations

Chloramphenicol 5% wit� lidocaine I %: ear drop. 10ml drop: 20.23 MRP

.:. ICOL EIE Drop ACI

Chloramphenicol 0.5% eye/ear drop. 1 0ml bot: 25 . 5 1 MRP

.:. OPSOPHENICOL Ear Drop Opsosaline

Chloramphenicol 5% ear drop. 1 0ml bot: 25.00 MRP

.:. OTOPHENICOL Ear Drop Reman & 10% ear drop.

Chloramphenicol 5%

5% x 5101 drop: 1 2.00 MRP 5% x IOml drop: 20.23 MRP 1 0% x 1 0101 drop: 1 9. 2 1 MRP

.:. OTO-Plus Ear Drop Edruc

Chloramphenicol 5% with lidocaine I %: ear drop.

Ind: Ear infection with earache. 1 0mi drop: 20.00 MRP

AURAL PREPARATIONS

.:. SQ-MYCETIN Ear Drop Square

Chloramphenicol 0.5% eye/ear drop. 1 0mi bot: 25 . S I MRP

Anti-bacterial preparations Owing to the potential risk of ototoxicity,

antibiotic containing preparations should be used with caution in the presence of perforation of the

tympanic membrane.

.:. SUPRAPHEN Ear Drop Gaco Chloramphenicol 5% & 1 0% ear drop. 5% x 10ml bot: 1 6.05 MRP 10% x 1 0101 bot: 1 7 . 1 9 MRP

.:. SUPRAPHEN Plus Ear Drop Gaco

Chloramphenicol 5% with lidocaine I %: ear drop.

Ind: Ear infection with earache. 10ml drop: I S.7 1 MRP

CHLORAMPHENICOL2 ,33

Ind: Otitis externa, acute otitis media, chronic suppurative otitis media, and prophylaxis during otic surgeries such as mastoid surgery.

cn:

Known hypersensitivity to ciprofloxacin.

Precaution: Prolonged use may result i n overgrowth of non susceptible organisms including fungi. The drug should be discontinued if the sign of hypersensitivity reaction .

Dose & Admin: Initially 2 to 3 drops every 2 to 3 hours; reducing the frequency of instillation gradually as infection is controlled. .:. CIFLOX Ear Drop Reman

Ciprofloxacin 0.3% ear drop. 5101 drop: 24.50 MRP 10mi drop: 40.00 MRP

.:. CIPROX Ear Drop Opsosaline

Ciprofloxacin 0.3% ear drop. 10mi drop: 30.00 MRP

.:. SPECTRA Ear Drop Jayson

Ciprofloxacin 0.3% ear drop. 5ml drop: 1 5 .00 IP

GENTAMICIN2 1 .)) GENTAMICIN: Ear Drop Ind: Bacterial infection in otitis externa SIE: Local sensitivity, ototoxicity. Caution: Perforated ear drum; avoid prolonged

use.

Adult & Child: 2-4 drops 3 or 4 times daily and at night. .:. GENACYN EIE Drop Square

Gentamicin sulphate 0.3% (or 3000 i.u/ml) : ear/eye drop. 1 0ml bot: 3 1 .9 1 MRP

.:. GENTA EarlEye Drop Renata

t

Gentamicin sulphate 0.3% (or 3000 i.u/ml):

CIPROFLOXACIN21.I O I

earleye drop

CHLORAMPHENICOL: Ear drop. Ind: Otitis externa; chronic otorrhoea,

CIPROFLOXACIN: Ear Drop

.:. GENTABAC Ear Drop Popular

suppurative otitis media; infection of fenestration

Ciprofloxacin hydrochloride monohydrate USP

and mastoid operation cavities.

1 0ml bot: 3 1 .93 MRP

equivalent to ciprofloxacin base 0.3% w/v.

Gentamicin sulphate 0.3% (or 3000 i.u/ml): ear drop

QIMP-15 (428)

DRUGS ACTING ON EAR, NOSE & OROPHARYNX 1 0ml bot: 3 1 .9 1 MRP

:. GENTIN EIE Drop Opsosaline

•


and well-controlled studies in pregnant women .

Gentamicin sulphate 0.3% (or 3000 i.u/ml):

This drug should be used during pregnancy only

ear/eye drop

if the potential benefit justifies the potential risk

10ml bot: 3 1 .25 MRP

to the fetus.

.:. GENTO EIE Drop Gaco

It is

ear/eye drop

ofloxacin eye & ear drop is administered during

Gentamicin sulphate 0.3% (or 3000 i.u/ml): 1 0ml bot: 3 1 ,50 MRP •:. G-GENTAMICIN EIE Drop Gonoshasthaya

Gentamicin sulph. 0,3% eye/ear drop, 1 0ml bot: 25,00 MRP •:.

GISIN EIE Drop Nipa

Gentamicin sulphate 0,3% (or 3000 i.u/ml):

not known whether ofloxacin is excreted in

hUlllan milk. Cautions should be taken when lactation,

Dosage & admin: Otitis externa: Instill 5 drops in the affected ear(s) twice daily for 10 days. Chronic suppurative otitis media: Instill 10 drops in the affected ear(s) twice daily for 14 days. 5ml drop: 85.00 MRP

eye/ear drop 1 0ml bot: 30,36 MRP

.:. RECIN EIE Drop Reman

OXYTETRACYCLINE62

Gentamicin sulphate 0.3% (or 3000 i,u/ml) : ear/eye drop 10mi bot: 3 1 .9 1 MRP

LOMEFLOXACIN LOMEFLOXACIN: EarlEye Drop

Lomefloxacin is a synthetic quinalone broad spectrum antimicrobial agent; available as ear and eye drop.

Ind: Otitis externa, acute otitis media, chronic

suppurative otitis media, and prophylaxis during

otic surgeries such as mastoid surgery.

CII; SIE; Cautions: See under the text of

lomefloxacin in the eye chapter.

Dose & Admin: Initially 2 to 3 drops every 2 to 3 hours; reducing the frequency of instillation gradually as infection is controlled. .:. LOMECIN EarlEye Drop Reman

Lomelloxacin hydrochloride 0,3% w/v: eye drop 5ml drop: 60,00 MRP

.:. LUMEX Ear/Eye Drop Gaco

Lomelloxacin hydrochloride INN 0.3% or 3mg/ml: eye drop 5ml drop: 50,00 IP

.:. LYFLOX EarlEye Drop Ibn Sina

Lomelloxacin hydrochloride INN 0.3% or 3mg/ml: eye drop

OXYTETRACYCLINE: Drop/ Ointment. Ind: Bacterial infection in otitis externa . S/E: Local sensitivity, Caution: Pelforated ear drums, avoid prolonged use.

Use & Admin: Ointment- pour a small amonnt of ointment in the external auditory meatus 2 to 4 times daily. Drop- lirst reconstituted solution, then 3-5 drops are instilled to the infected ear at an interval of 2 to 3 houl's; after each instillation maintain the ear turned upward for few minutes to provide max. contact of the drug with the affected area. .:. RENAMYCIN EIE Oint. Renata

Oxytetracycline hydrochlor. 5mg and Polymyxin- B sulph, I mg ( 1 0.000 units)igm of ear/eye ointment. 3,5gm tube: 1 7.42 MRP

.:. RENAMYCIN Otic Soln. Renata

Oxytetracycline 2Smg, Polymyxin-B sulph,

SO.OOO units and Benzocaine 250mg/Sml drop.

Ind: Bacterial infection in otitis externa (with

severe pain),

5ml vial: 24. 1 8 MRP

5ml drop: 60.00 MRP

OFLOXACIN36

Antifungal preparations CLOTRIMAZOLE21 ,33

Mode of action: Otloxacin is a bacterial DNA

.:. KANIS Ear Drop Gaco

Ofloxacin USP 0,3%: earleye drop

duplication, transcription and repair of bacterial DNA,

Ind: It is indicated for the treatment of external

ear infections (otitis external and certain middle ear infections ( otitis media)

ell:

Known hypersensitivity to ofloxacin or any

other component of this preparation,

SIE: Mild irritation or mild discomfort in the ear may occur. Symptoms of an allergiC reaction

include rash. itching. swelling or trouble

result in overgrowth of non-susceptible

organisms and secondary infection respectively.

Betamethasone sodium phosphate 0. 1 % w/v & benzalkonium chloride 0,02 %w/v: ear drop.

Ind: Non-infected inflammtory ear conditions

(e.g eczematous inflammation in otitis externa).

CII: Untreated infection, Caution: Avoid prolonged use . Dosage & admin: Adult & Child: 2 to 3 drops 2 or 3 hourly; reduce freqnency of application when relief is obtained. .:. BETRICIN Ear Drop Nipa

Betamethasone sodium phosphate 0. 1 %: ear drop, 5ml drop: 29.33 MRP

.:. CELUDEX E!E Drop Drug Inter.

Betamethasone sodium phosphate 0. 1 %: ear drop. 1 0ml drop: 55.00 MRP

.:. EYEBET Ear Drop Incepta

Betamethasone sodium phosphate 0. 1 %: ear drop, 5ml drop: 30,00 MRP

.:. METHASOL EarlEye Drop Gaco

Betamethasone sodium phosphate 0. 1 %: ear drop. 5ml drop: 3 1 ,80 MRP

BETAMETHASONE + NEOMYCIN BETAMETHASONE + NEOMYCIN: Ear drop Betamethasone sodium phosphate O. I % & neomycin sulphate 0,5%: ear/eye drop.

Ind: Otitis externa and other infective and inflammatory ear conditions.

CII: Perforated ear drum, Caution: Pregnancy. Dosage & admin: Adult & Child: 2 to 3 drops 2 or 3 bonrly. .:. ARISTOBET-N Ear Drop Aristopharma

Betamethasone sodium phosphate 0, I % & neomycin sulphate

O.S%:

Ear drop.

5ml vial: 32.20 MRP

.:. BETACIN-N Ear Drop Ibn Silla

Betamethasone sodium phosphate 0. 1 % & neomycin sulphate 0.5%: Ear drop.

.:. BETASON-N Ear Drop Reman

Betamethasone sodium phosphate 0. 1 % & neomycin sulphate 0.5%: Ear drop, 5ml vial: 32,20 MRP

.:. BETRICIN-N Ear Drop Nipa

Clolrimazole 1 0mgllml: ear drop,

Betamethasone sodium phosphate 0, I % & neomycin sulphate 0.5%: Ear drop

Ind: Fungal infections afthe ear due to candida

Sml drop: 30,36 MRP

CII: History of hypersensitivity to clotrimazole. SIE: Local reactions immediately after applying

Betamethasone sodium phosphate 0, I % &

species and aspergillus fumigatlls.

the ear drops,

Dose & Admin: 1 to 2 drops to be instilled every 5-6 hours in the ear canal or as advised by the physician. 1 0mi drop: 60,00 MRP

.:. BN Ear Drop Asiatic

neomycin sulphate 0.5%: Ear drop 5ml drop: 28.45 MRP

.:. METHASOL-N Ear Drop Gaco

Betamethasone sodium phosphate 0, I % & neomycin sulphate 0,5%: Ear drop 5ml drop: 32,20 MRP

.:. OPTISON-N Ear Drop OpsoSaline

breathing,

Precautions: Prolonged lise of ear drops may

BETAMETHASONE: Ear drop

Sml vial: 30.34 MRP

.:. VISTA EarlEye Drop Aristopharma

gyrase inhibitor, the enzyme responsible for

BETAMETHASONE

Steroid & Steroid/Antibiotic combined prepns.2 1.33

Betamethasone sodium phosphate 0. I % & neomycin sulphate

OS)'o:

Sml drop: 30,30 MRP

Ear drop

QIMP-15 (429)

.:. APRODEX EIE Drop Aristopharma

DEXAMETHASONE

DRUGS ACTING ON EAR, NOSE & OROPHARYNX

.:. GENTIN HC Ear Drop Opso saline

Dexamethasone sodium phosphate 0. 1 % &

Hydrocortisone acetate 1 % & gentamicin

ciprofloxacin 0.3%: eye/ear drop.

sulphate 0.3%: ear drop

DEXAMETHASONE: EarlEye drop

5ml drop: 65.00 MRP

5ml drop: 40.00 MRP

Dexamethasone sodium phosphate 0. 1 % ear/eye

.:. BACTIN-D EIE Drop Ibn Sina

.:. GENTO-HC Ear Drop Gaco



Ind: Non-infected inflammatory ear conditions

ciprofloxacin 0.3%: ear/eye drop.


(including eczema).

.:. BEUFLOX-D E/E Drop Incepta

drop.

5ml drop: 75.00 MRP

I·Oml drop: 50.85 MRP

.:. GISIN-H Ear Drop Nipa

CII: Untreated infection. Caution: Avoid prolonged use. Adult & Child: 1 to 2 drops every 1-4 hours_



ciprofloxacin 0.3%: ear/eye drop.


6ml drop: 75.00 MRP

.:. CERODEX E/E Drop Gaco

5ml drop: 40.90 MRP

.:. ACICOT EIE Drop ACI

Dexamethasone 0. 1 % ear/eye drop.

Dexamethasone sodium phosphate 0 . 1 % &

5ml drop: 36.00 MRP

ciprotloxacin 0.3%: eye/ear drop.

.:. DEXACORT EIE Drop Opsosaline

5ml drop: 75.00 MRP

5ml drop: 40.00 MRP



:. DEXADRON E/E Drop Reman

•

.:. CIP-D EIE Drop Asiatic

ciprotloxacin 0.3%: eye/ear drop .


5ml drop: 75.00 MRP

4ml drop: 60.00 MRP

.:. CIVODEX EIE Drop Popular

.:. DEXAMIN EIE Drop Jayson

HYDROCORTISONE + NEOMYCIN + POLYMYXIN·B47.l o3


HYDROCORTISONE + NEOMYCIN + POLYMYXIN-B: Ear drop This combination product of hydrocortisone acetate, neomycin sulphate and polymyxin-B sulphate is available as ear drop.

Dexamethasone 0. 1 % eye/ear drop.


Comp: See below under individual preparation.

5ml drop: 50.00 lP

5ml drop: 75.00 MRP

Ind: Bacterial infections and intlammation of

.:. D-ONE EIE Drop Nipa

.:. OPDEX EIE Drop Nipa

Dexamethasone 0. 1 %: eye/ear drop.


5ml drop: 50.00 MRP


.:. MERADEXON Eye/Ear Drop Gaco

5ml drop: 65.00 MRP

Dexamethasone O. I % eye/ear drop. 5ml drop: 50.00 MRP

.:. METADAXAN EIE Drop Incepta

Dexamethasone

o. I % ear/eye

drop.

HYDROCORTISONE + CIPROFLOXACIN36

5ml drop: 60.00 MRP

.:. OCUDEX Eye Drop Asiatic

Dexamethasone 0. 1 % eye drop. 5ml drop: 50.00 MRP

HYDROCORTISONE + CIPROFLOXACIN: Ear drop Hydrocortisone acetate 1 % & ciprofloxacin 0.3%: ear drop

DEXAMETHASONE + CIPROFLOXACIN DEXAMETHASONE + CIPROFLOXACIN: EarlEye drop Dexamethasone sodium phosphate 0. 1 % & ciprofloxacin 0.3%: eye/ear drop.


CII: Perforated ear drum. Known hypersensitivity to any ingredient of the product. Herpes simplex and other viral conditions of the ear, mycosis. newborn babies, fungal diseases of auricular structures.

SIE: The most common adverse effects are discomfort and ear pain. Other reported reactions are irritability, dizziness. erythema etc.

Precautions: This product should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether topical steroids would result in sufficient systemic absorption to produce detectable quantities in human milk. It is also not known whether ciprotloxacin is excreted in human milk following auricular use, so, caution should be exercised when the product is advised to a nursing mother, i.e whether to discontinue

nursing or to discontinue the drug.

Dosage & appli: Adult & Child: Instil 2-4 drops 2-4 times daily. Care should be taken not to discontinue therapy prematurely.


CII; SIE; Precautions: See above under the text of 'dexamethasone + ciprotloxacin! preparations.

Dosage & appli: Adult & Child: Instil 2-4 drops 2-4 times daily_ Care should be taken not to discontinue therapy prematurely. .:. CERO-HC Otic Drop Gaco

Hydrocortisone acetate 1 % & ciprofloxacin 0.3%: ear drop 1 0mi drop: 55.00 MRP

.:. CIPROCORT Otic Drop Drug Inter.

Hydrocortisone acetate 1 % & ciprofloxacin 0.3%: ear drop 1 0mi drop: 54.00 MRP

HYDROCORTISONE + GENTAMICIN HYDROCORTISONE+GENTAMICIN: Ear drop Hydrocortisone acetate 1 % & gentamicin sulphate 0.3%:

ear drop

Ind: Otitis externa; chronic suppurative otitis. Caution: Avoid prolonged use; perforated ear dntm.

Dosage & appli: Adult & Child: 2 to 4 drops 3 or 4 times daily and at bedtime. .:. GENTABAC HC Ear Drop Popular

external ear & auditory canal.

CII: Viral & tuberculous infections. Cautions: Pregnancy; limit use to 10 days if ear drum is perforated; Avoid long term use in infants.

Dosage & appli: Adult & Child: Install 3 drops 3 or 4 times daily or isert soaked wick, keeping it saturated_ .:. NPH Ear Drop Reman

Hydrocortisone acetate 1 0mg/ml ( I %), neomycin sulphate 3400 units/ml (0.34%). polymyxin-B sulphate 1 0,000 units/ml: ear drop 5ml vial: 45.00 MRP

.:. OTOSPORIN Ear Drop GlaxoSmithKline

Hydrocortisone acetate 1 % . neomycin sulph.

0.5%, polymyxin-B sulph. 1 0,000 units/ ml; ear drop 5ml vial: 45.5 1 MRP

.:. POLYCORT Ear Drop Gaco

Hydrocortisone acetate I %, neomycin sulph. 0.5%, polymyxin-B sulph. 1 0,000 units/ml: ear drop 5ml vial: 45.00 IP

.:. POLYMIX-H Ear Drop Opsosaline

Polymyxin B sulph. 1 0,000 units, neomycin sulph. 3000 units & hydrocortisone BP 1 0mg/ l ml: ear drop. 5ml drop: 40.00 MRP

PREDNISOLONE + NEOMYCIN PREDNISOLONE + NEOMYCIN: EarlEye drop Prednisolone acetate 5mg & neomycin sulphate 5mg/1 ml: ear/eye drop.

Ind: Infected ear & ocular inflammation. Adult & Child: 1-2 drops 3 to 4 times daily or more frequently if reqd_ .:. DELTASONE-N E/E Drop Renata


Prednisolone acetate 5mg & neomycin sulphate


5mg/lml: ear/eye drop.


5ml drop: 39.98 MRP

QIMP-15 (430)


should be exercised when azelastine

NASAL PREPNS.

hydrochloride is administered to a nursing mother.

Dosage & admin: Adults & children 12 years & older: 2 sprays in each nostril twice daily. Children 5-11 years of age: 1 spray in each nostril twice daily. Initial pump priming requires severe sprays of the pump. If used regularly as recommended, not further priming is required. If not used more than 24 hours, the pump will require 2 sprays, or if not used for more than seven days, the pump will require 7 sprays. The safety & effectiveness of azelastine hydrochloride nasal spray in patients below 5 years of age have not been established. Drug inter: If azelastine hydrochloride is taken

Nasal preparations discussed herein below include: 1. Anti-histamine preparations 2. Anti-cholinergic preparations 3. Mast cell stabiliser 4_ Combined nasal preparations 5. Nasal steroid preparations

Anti-histamine preparations AZELASTINE42

with certain other drugs, the effects of either

AZELASTINE: Nasal spray (MOl)

could be altered. It is specially important to

Azelastine hydrochloride nasal spray is an

antihistamine formulated as a metered dose spray solution for intranasal administration. It is a metered dose manual pump spray which delivers azelastine hydrochloride BP 137mcglactuation.

Mode of action: Azelastine is an antihistamine, a phthalazinone derivative, exhibits histamine H receptor antagonist activity in isolated tissues,

I

animal models, & humans. It is administered as a recemic mixture with no difference in

pharmacologic activity noted between the enantiomers in in-vitro studies. The major metabolite, desmethylazelastine also possesses H I-receptor antagonist activity.

check before combining azelastine with the

components.

SIE: Common side effects may include bitter taste. drowsiness, headache, loss of sensation. nasal burning, & sore throat. Less common side

.:. AZELAST Nasal Spray (MOl) Incepta

Azelastine hydrochloride BP I 37mcglactuation

(spry): metered dose nasal spray solution for intranasal administration. 120 doses unit. 1 20 doses (spray) unit: 1 80.00 MRP

.:. SNIZEX Nasal Spray (MOl) Square

Azelastine hydrochloride BP 137mcg/actuation

1 20 doses (spray) unit: 1 80.00 MRP

EPHEDRINE HCJ2 I . JOJ .:. REMADRIN Nasal Drop Reman

Ephedrine hydrochloride 0.5% nasal drop.

Ind: Nasal congestion. SIE: local in-italian; after excessive use tolerence

with diminished effect, rebound congestion.

Caution: Avoid excessive use; caution in infants under 3 months (no good evidence of value- if

effects may include abdominal pain, abnormal

irritation occurs might narrow nasal passage).

thinking, allergic reaction, anxiety, back pain, constipation, coughing, depression, dizziness, dry

Use: Instil 1-2 drops into each nostril upto 3 or 4 tims daily when required.

mouth. eye problems. fatigue, frequent urination,

10mi drop: 45.52 MRP

increased appetite, loss of menstruation, mouth & tongue sores, nasal inflaminations & nausea.

Precautios & warnings: In clinical trials, the

PSEUDOEPHEDRINE26.47

caution should therefore be exercised when driving a car or operating potentially dangerous machinery. Concurrent use of it with alcohol or

machinery. Concurrent use of it with alcohol or other CNS depressants should be avoided

it should be used with caution in patients with

hypertension, heart disease, diabetes, hyperthyroidism, elevated intraocular pressure

and prostatic enlargement. Caution should also be

exercised when using in the patients with severe hepatic impairment or moderate to severe renal impairment.

Pregnancy & lactation: As there are no specific

data on the use of pseudoephedrine during

pregnancy, it should only be used if the potential

Pseudoephedrine is excreted in breast milk in infant is unknown.

Dosage & Admin: As a decongestant and symptomatic treatment for upper respiratory tract infections: Adults- 60mg every 4-6 hours, up to maximum of 240mg in 24 hours. Children- 6-12 years of ege, 30mg every 4-6 hours daily; 2-5 years of age, t5mg every 4-6 hours daily; for children less than 2 years of age, the drug is not advised unless specifically recommended by a physician. Overdosage: As with other sympathomimetic agents, symptoms of overdosage include

irritability, restlessness, tremor, convulsions, palpitations, hypertension and difficulty in

micturition. Necessary measures should be taken to maintain and support respiration and control

convulsions. Gastric lavage should be performed if indicated. If desired, the elimination of

pseudoephedrine can be accelerated by acid diuresis or by dialysis.

Drug inter: ConcUiTent administration of other sympathomimetics may lead to additive CNS or CYS effects. Increased absorption has been reported with the concurrent administration of aluminium hydroxide antacid.

.:. SUDAFED Tab, GlaxoSmithKline

Pseudoephedrine hydrochloride 60mg/tablet. 1 00'5 pack: 201 .00 MRP

.:. SUDORIN Tab. Incepta

Pseudoephedrine hydrochloride 60mg/tablet.

occun-ence of somnolence has been reported in some patients taking azelastine nasal spray; due

patients, as with other sympathomimetic agents.

small amounts but the effect of this on breast-fed

from light. Do not freeze.

congestion & postnasal drip in adults & children

azelastine hydrochloride or any of its

Precautions: Although pseudoephedrine has

virtually no pressor effect in normotensive

Storage: Store in a cool & dry place, protected

restoril, cimetidine & ketoconazole.

pruritus in adults & children of 5 years & older,

CII: Patients with known hypersensitivity to

occasionally,

benefit of treatment to the mother is more than

intranasal administration. 120 doses unit.

of 1 2 years & older.

sleep disturbance & rarely hallucinations. Skin

rash & urinary retention has been reported

any possible hazards to the growing foetus.

treatment of the symptoms of seasonal allergic

vasomotor rhinitis, such as rhinorrhea, nasal

SIE: Serious adverse effects are extremely rare.

Occasionally CNS symptoms such as, excitation,

system, including codeine, phenobarbital &

(spry): metered dose nasal spray solution for

& for the treatment of the symptoms of

inhibitor drugs.

followng; alcohol, drugs that slow the nervous

Ind: Azelastine nasal spray is indicated for the rhinitis, such as rhinorrhea, sneezing. and nasal

concurrent use of monoamine oxidase (MAO)

PSEUDOEPHEDRINE: Tablet

Pseudoephedrine is a stereoisomer of ephedrine

with similar but less potent pharmacological

activity. It has nasal and bronchial decongestant

100's pack: 200.00 MRP

.:. SUDOTAB Tab. Opsonin

Pseudoephedrine hydrochloride 60mg/tablet. 1 00's pack: 200.00 MRP

activity.

Ind: Pseudoephedrine is a decongestant of the

XYLOMETAZOLINE HCp3.42

because additional reduction in alertness &

mucous membrane of the upper respiratory tract,

occur. Do not spray in the eyes.

eustachian tube. It is indicated for the

hydrochloride during pregnancy have not been

vasomotor rhinitis, common cold, influenza (flu)

nasal decongestant. It is a sympathomimetic

infection. Pseudoephedrine can also be used as a

drop & spray.

additional impairment of CNS performance may

Pregnancy & lactation: The effects of azelastine adequately studied. Azelastine should be

administered during pregnancy, if the potential

benefit justifies the potential risks to fetus.

It is not known whether azelastine hydrochloride is excreted in human milk. However, caution

specially the nasal mucosa, sinuses and

symptomatic relief of allergic rhinitis (hay fever), and ear congestion caused by ear intlammation or

XYLOMETAZOLINE: Nasal Drop/Spray Xylometazoline hydrochloride is an effective amine of the imidazole class. Available as nasal

bronchodilator.

Mode of action: Xylometazoline hydrochloride

severe hypertension and coronary artery disease,

adrenergic activity. It is a direct agonist of 2

CII: Hypersensitivity of individuals to this drug,

is a sympathomimetic agent with alpha

QIMP·15 (431)

adreno·receptors. It constricts the nasal blood vessels, thereby, decongesting the mucosa of the nose and neighbouring regions of the pharynx. This enables patients suffering from common colds to breathe more easily through the nose. The action begins within a few minutes of administration

years, instill 2-3 drops of 0.05 % solution & · under 6 years, 2-3 drops of 0.025 % solution into each nostril, 2 to 3 times daily. Duration of treatment 3-5 days; maximum duration 2 weeks. Nasal spray- Instill 2-3 sprays into each nostril 2 times daily.


effects) that are seen with teniary anticholinergic amines.

Ind: Treatment and management of perennial rhinitis, allergic rhinitis & vasomotor rhinitis when characterized by watery rhinorrhoea; symptomatic relief of rhinorrhoea associated with the common cold. It does not relieve nasal

and persists for several hours.

congestion, sneezing, or postnasal drip associated

Ind: Nasal congestion associated with perennial

with allergic or non-allergic perennial rhinitis.

and seasonal rhinitis, sinusitis.

CII: Known hypersensitivity to atropine or its

CII: Patients having hypersensitivity to

derivatives, or to any of the ingredients of the

xylometazoline.

product. Rarely, immediate hypersensitivity

SIE: Side effects with xylometazoline nasal spray

reactions may occur after administration of

are infrequent and mild. There may be in rare

ipratropium bromide, Cas demonstrated by

instances, local stinging, sneezing, dryness of

urticaria, angioedema, rash, bronchospasm, and

nose, drowsiness, headache and palpitation. It

oropharyngeal edema).

SIE: The most frequent local undesirable effects

may occasionally cause systemic sympathomimetic effects such as hypenension, nervousness, nausea, dizziness, insomnia, tachycardia and arrhythmia.

Precaution: Should not be used for prolonged period, as it is a sympathomimetic amine; use of which may lead to rebound symptoms on withdrawal of treatment; use with extreme caution in persons receiving MAOI,s

.:. AFRIN Drop Aristopharma

Oxymetazoline hydrochloride 0.05% nasal drop.

0.05% drop x I Oml: 35.00 MRP

Pregnancy & lactation: The safety of use in pregnancy has not been fully established and administration of xylometazoline during this period should be avoided unless absolutely essential. No adverse effects have been reponed in the baby as a result of breast feeding mother taking the drug.

Dosage & admin: Nasal drop: Adult: 2 to 3 drops of 0.1 % soln. in each nostril 2 or 3 times daily. Child: 1 to 2 drops of 0.05 % soln. in each nostril once or twice daily. Nasal spray· dosage & administration see below under the AntazoI nasal spray. Drug inter: No information regarding drug interaction is available.

occur as non-specific reactions in association

for paediatric use.

Potential systemic anticholinergic effects are dry

Oxymetazoline hydrochloride 0.025% nasal drop

1 0mi vial: 30.00 MRP Oxymetazoline hydrochloride 0.05% nasal spray; 25mcgfactuation or spray: 200 metered sprays. I spray unit of 200 doses: 80.00 IP

.:. NOCON Drop Square


0.05% drop x IOml: 35.00 MRP

.:. NOCON Paediatric Drop Square

Oxymetazoline hydrochloride 0.025% nasal drop for paediatric use.

10mi vial: 30.00 MRP

Xylometazoline hydrochloride 0.05%

& 0. 1 %:

0.05% x 15ml drop: 6.97 MRP 0. 1 % x 15ml drop: 7.61 MRP

:. NOVIN Drop Gaco

.

mouth and dry throat. Ocular side effects, increase of heat1 rate and palpitations, urinary retention and gastrointestinal motility disturbances have been reproted in isolated patietns in association with use of ipratropium bromide either intranasally or after oral inhalation. Allergic-type reactions such as skin rash, angio-oedema of tongue, lips and face, unicaria, laryngospasm and anaphylactic reactions may occur.

Precautions: Ipratropium bromide nasal spray should be used with caution in patients with narrow-angle glaucoma, or with prostatic


with cystic fibrosis may be more prone to gastro

.:. RYNEX Nasal Spray Incepta

hyperplasia or bladder neck obstruction. Patients intestinal motility disturbances. Do not spray in

Oxymetazoline hydrochloride 0.05% nasal spray;

the eyes.

25mcgfactuation or spray: 200 metered sprays.

Pregnancy & lactation: The safety of ipratropium bromide nasal spray during pregnancy has not been established, although

nasal drop


with use of ipratropium bromide nasal spray.

.:. RYNEX Nasal Drop Incepta


I spray unit of 200 doses: 80.00 MRP

.:. ANTAZOL Nasal Drop Square

and local irritation (e.g burning sensation) may

.:. AFRIN Paediatric Drop Aristopharma

.:. NAZOLIN Nasal Spray Beximco

concurrently

are nasal reactions including epistaxis, dryness of the nose and nasal irritation. Headache, nausea

& 0. 1 %:

Anticholinergic (Anti muscarinic) Preparations IPRATROPIUM42

nasal drop

0.05% x lOml drop: 5.95 MRP

.:. RYNASPRAY Nasal spray CMOI) Spuare

0. 1 % x lOml drop: 6.72 MRP

Ipratropium bromide BP 2 1mcgfspray (metered dose nasal spray) .

:. RIDNOZOL Drop Acme

•

preclinical studies showed no embryotoxic or teratogenic effects following inhalation at doses considerably higher than those recommended in man. However, the benefits of using this spray during a confirmed or suspected pregnancy must be weighed against possible hazards to the unborn child. It is not known whether ipratropium bromide is excreted in human milk. Because, many drugs are excreted into human milk, caution should be exercised when ipratropium bromide nasal spray

Xylometazoline hydrochloride 0.05% & 0. 1 %:

Mode of action: Ipratropium bromide is a

nasal drop

synthetic quaternary anti-cholinergic

is administered to a nursing mother.

0.05% x 15ml drop: 6.97 MRP

parasympatholytic ammonium compound,

0. 1 % x 15ml drop: 7.6 1 MRP

chemically related to atropine, that inhibits

Dosage & admin: Perennial rhinitis, allergic rhinitis & vasomotor rhinitis when characterized by watery rhinorrhea: Adults & children age 5 years & older- 2 sprays into each nostril 2-4 times daily. Symptomatic relief of rhinorrhea associated with the common cold: Adults & children age 5 years & older- 2 sprays into each nostril 2-4 times daily. The safety and effectiveness of ipratropium bromide nasal spray beyond 3 weeks in patients with allergic rhinitis and 4 days in patients with the common cold have not been established. Initial pump priming requires seven sprays of

.:. XYLOVIN Drop Opsosaline


vagally-mediated reflexes by antagonizing the

& 0. 1 %:

action of acetylcholine at the cholinergic receptors. It is a competitive antagonist at the

nasal drop

0.05% x 1 0mi drop: 7.25 MRP

muscarinic acetylcholine receptors. In humans,

0. 1 % x lOml drop: 7.25 MRP

ipratropium bromide has antisecretory propenies and when applied locally, inhibits secretions from

OXYMETAZOLINE

HeFt .33

the serous and seromucous glands lining the nasal mucosa. Ipratropium bromide is a quaternary amine that minimally crosses the

OXYMETAZOLINE: Nasal Dropf Spray Ind: Nasal congestion Cautiou: Same as xylometazoline (above). Dosage & admin: Adult & Childreu: Over 6

nasal and gastrointestinal membrane and the blood-brain barrier, resulting in a reduction of the systemic anticholinergic effects Ce.g neuroleptic, ophthalmic, cardiovascular, and gastrointestinal


QIMP-J5 (432)

the pump. If used regularly as recommended, no further priming is required. If not used more than 24 hours, the pump will require 2 sprays, or if not used for more than seven days the pump will require 7 sprays. Drug inter: No controlled clinical trials were conducted to investigate drug interactions. Ipratropium bromide nasal spray in minimally absorbed into the systemic circulation; nonetheless, there is some potential for additive interaction with other concomitantly administered anti-cholinergic medications, including ipratropium bromide containing aerosols for oral inhalation. 120 sprays unit: 1 48.00 MRP

XYLOMETAZOLINE HCI+ SODIUM CROMOGLICATE: Nasal Spray This is a combined preparation of xylometazoline hydrochloride and sodium cromoglicate, available as metered dose nasal spray. Each metered dose spray delivers xylometazoline hydrochloride BP 0.032Smg and sodium cromoglicate BP 2.6mg. Mode of action: See above under the text of 'xylometazoline' and 'sodium cromoglicate' separately. Ind: It is indicated for the prophylaxis and treatment of allergic rhinitis (such as hay fever and perennial rhinitis) where this is accompanied by nasal congestion.

Mast Cell Stabiliser

CII: Known sensitivity to any ingredients of the preparation.

SODIUM CROMOGLYCATE21 ,33

SIE; Precautions: See above under the text of 'xylometazoline' and lsodium cromoglicate' separately.

SODIUM CROMOGLYCATE: Nasal (& eye) Drop Sodium cromoglicate is a mast cell stabiliser. It is available as 2% & 4% nasal (& eye) drop. Mode of action: Sodium cromoglicate usually acts through a local effect on the nasal mucosa. It prevents release of the mediators of type-I allergic reactions, including histamine and slow reacting subatance of anaphylaxis (SRS-A) from sensitized mast cells after the antigen-antibody union has taken place. The drug dose not inhibit the binding of IgE and the specific antigen; instead it suppresses the release of substances (e.g histamine, SRS-A) in response to this reaction. The drug also inhibits type-Ill (late allergic, Arthers) reactions lesser extent. Ind: Prophylaxis of allergiC rhinitis. SIE: Transient nasal irritation; rarely wheezing (bronchospasm) and tightness of the chest has been reported. Dosage & appli: Adult & Child: 1 drop to each nostril 4 to 6 times daily. Therapy should be continous. .:. ARISTOCROM Nasal Drop Aristopharma Sodium cromoglycate 2%; nasal (& eye) drop. 10m! drop: 6S.OO MRP .:. CROMOLIN Nasal Drop Ibn Sina Sodium cromoglycate 4%; nasal (& eye) drop. 1 0m! drop: 7S.OO MRP .:. NACROMIN Nasal Drop Square Sodium cromoglycate 2%; nasal (& eye) drop. I S ml drop: 66.00 MRP .:. NASOCHROM Nasal Drop Drug Inter. Sodium cromoglycate 2%; nasal (& eye) drop. I Oml drop: 60.00 MRP .:. OPSOCROM Nasal Drop Opsosaline Sodium cromoglycate 2%; nasal (& eye) drop. 10m! drop: SS.OO MRP .:. OPTACROM Nasal Drop Reman Sodium cromoglycate 2%; nasal (& eye) drop. 10m! drop: 60.00 MRP

Combined Nasal Preparations XYLOMETAZOLINE HCI + SODIUM CROMOGLICATE42

Pregnancy & lactation: As with all medicines, caution should be exercised during pregnancy specially during the first trimester. Dosage & admin: Adults (including the elderly) and children: one spray to each nostril 4 times daily. .:. ANTAZOL Plus Nasal Spray Square Each metered dose spray delivers 2.6mg of sodium cromoglicate and 0.032Smg of xylometazoline hydrochloride: Metered dose nasal spray 1 20 sprays unit: 1 10.00 MRP

Nasal Steroid Prepns.42,47 NASAL CORTICOSTEROID PREPNS: Metered dose nasal spray or inhalation Ind: Prophylaxis and treatment of seasonal & perennial allergic rhinitis, including hayfever & non-allergic (vasomotor) rhinitis, Prevention of recurrence of nasal polyps following surgical removal. CII: Patients with a hypersensitivity to any of the steroid preparation. SIE: As with other nasal sprays, dryness and irritation of the nose and throat, unpleasant taste and smell and epistaxis have been reported. Hypersensitivity reactions including skin rash, oedema of the face or tongue and anaphylactic reactions have been reported.There have also been rare reports of bronchospasm. Extremely rare cases of nasal septal perforation have been reported following the use of intranasal corticosteroids. Precautio'!s: Nasal steroid preparations should not be used in the presence of untreated localized infections of the nasal passage and paranasal sinuses & should be used with caution, if at all, in patients with active or quiescent tuberculous infections of the respiratory tract, or in untreated fungal, bacterial, systemic viral infections or ocular herpes simplex. In case of recent nasal surgery or trauma, any nasal corticosteroid should not use until healing is complete. In the cases of long-term treatment with steroid

nasal spray over several months or longer, patients should be examined periodically for possible changes in the nasal mucosa. If localized fungal infection of the nose or pharynx develops, discontinue the nasal spray therapy or appropriate treatment may be required. Persistence of nasopharyngeal irritation may be an indication for discontinuing therapy. There is no evidence of hypothalamic pituitary adrenal (HPA) axis suppression following prolonged treatment with steroid nasal spray. However, patients who are transferred from long tenn administration of systemically active corticosteroids to any steroid nasal spray require careful attention. Systemic corticosteroid withdrawal in such patients may result in adrenal insufficiency for a number of months until recovery of HPA axis function. If these patients exhibit signs and symptoms of adrenal insufficiency, systemic corticosteroid administration should be resumed and other modes of therapy and appropriate measures instituted. Patients receiving corticosteroids who are potentially immunosuppressed should be warned of the risk of exposure to certain infections (e.g chicken pox, measles) and of the importance of obtaining medical advice if such exposure occurs.

Pregnancy & lactation: There are no adequate or well controlled studies in the cases of pregnancy & nursing women. Therefore, steroid nasal spray should be used in pregnancy, nursing mothers or women of childbearing age only if the potential benefit justifies the potential risk to the mother, fetus or infant. Infants born of mothers who received corticosteroids during pregnancy should be observed carefully for hypoadrenalism. Dosage & admin: See below under individual steroid preparation.

BECLOMETHASONE42.47 BECLOMETHASONE DIPROPIONATE: Nasal Spray Beclomethasone dipropionate aqueous suspension for nasal spray. Each spray or actuation of available preparations delivers beclomethasone dipropionate SOmcg. Ind: Prophylaxis and treatment of seasonal & perennial allergic rhinitis, including hayfever & non-allergic (vasomotor) rhinitis. Prevention of recurrence of nasal polyps following surgical removal. CII; SIE; Precaution: See above under the text of nasal corticosteroid preparations. Pregnancy & lactation: See above under the text of nasal corticosteroid preparations. Dosage & admin: Adult- 2 applications in each nostril twice daily. Therapy should be continuous. Child- under 6 years, not recommended; 6-12 yrs, same as adult. .:. BECONASE Aq. Nasal Spray GlaxoSmithKline Beclomethasone dipropionate SOmcgimetered dose (spary): aqueous suspension for nasal spray. 200 dose (spray) unit: 234.66 MRP

QIMP-15 (433)

.:. BECOSPRAY Nasal Spray Square

FLUTICASONE PROPIONATE: Nasal Spray

Beclomethasone dipropionate 50mcglmetered dose (spary): aqueous suspension for nasal spray. 200 dose (spray) unit: 125.00 MRP

.:. DECOMIT Nasal Spray Beximco

F1uticasone propionate is an aqueous solution for nasal spray. Each spray or actuation of available preparations delivers f1uticasone propionate 50mcg.

Beclomethasone dipropionate 50mcglmetered dose (spary): aqueous suspension for nasal spray. 200 dose (spray) unit: 146.00 IP

allergic rhinitis including hay fever, and perennial rhinitis.

BETAMETHASONE & BETAMETHASONE + NEOMYCIN PREPNS21,33.47 BETAMETHASONE + NEOMYCIN: Nasal drop Betamethasone sodium phosphate 0 . 1 % & neomycin sulphate 0.5%: nasal drop. Ind: Allergic rhinitis and other inflammatory conditions with bacterial infection. CII; SIE; Precaution: See above under the text of nasal corticosteroid preparations. Pregnancy & lactation: See above under the text of nasal corticosteroid preparations. Dosage & appli: Adult & child: 2 to 3 drops in each nostril 3 or 4 times daily.

.:. ARISTOBET-N Drop Aristopharma Betamethasone sodium phosphate 0 . 1 % & neomycin sulphate 0.5%: nasal drop. 5rn1 vial: 32.20 MRP

.:. BETASON-N Drop Reman

Betamethasone sodium phos. 0 . 1 % & neomycin sulphate 0.5%: nasal drop. 5rn1 vial: 32.20 MRP

BUDESONIDE26

Ind: Prophylaxis and treatment of seasonal

CII; SIE; Precaution: See above under the text of nasal corticosteroid preparations. Pregnancy & lactation: See above under the text of nasal corticosteroid preparations.

Dosage & Admin: Adults & children over 12 years of age: 2 sprays into each nostril once a day, preferably in the morning; in some cases two sprays into each nostril twice daily may be required; the maximum daily dose should not exceed four sprays into each nostril. Elderly- the normal adult dosage is applicable.

Children under 12 years of age (4 to llyears): 1 spray into each nostril once a day, preferably in the morning; in some cases one spray into each nostril twice daily may be required; the maximum daily dose should not exceed two sprays into each nostril. For full therapeutic benefit regular usage is essential. The absence of an immediate effect should be explained to the patient as maximum relief may not be obtained until after 3 to 4 days of treatment. .:. FLIXONASE Aq. Nasal Spray GlaxoSmitbKline Fluticasone propionate BP 50mcglactuation or puff: an aqueous suspension for metered dose nasal spray or inhalation. 120 doses (sprays) unit (20rnl): 350.00 MRP

.:. FLONASPRAY Nasal Spray Square BUDESONIDE: Nasal Spray Budesonide is a synthetic corticosteroid available as aqueous suspension for metered dose nasal spray or inhalation. Each spray or actuation of available preparations delivers budesonide BP l oomcg. Ind: Prophylaxis and treatment of seasonal and perennial allergic rhinitis; prophylaxis and treatment of vasomotor rhinitis; symptomatic relief of nasal polyposis; prevention against nasal polyps after polypectomy. CII; SIE; Precaution: See above under the text of nasal corticosteroid preparations. Pregnancy & lactation: See above under the text of nasal corticosteroid preparations.

Dosage & admin: Adults & children 6 yrs of age & older: l00mcglday administered as one spray in each nostril once daily. The maximum recommended dose for adults (12 yrs of age & older) is 400mcg/day administered as 4 sprays in each nostril once daily. .:. BUDICORT Nasal Spray Incepta Budesonide BP l oomcg/actuation or inhalation: aqueous suspension for metered dose nasal spray or inhalation. 120 metered dose (spray) unit: 230.00 MRP

FLUTICASONE42,47

Fluticasone propionate BP 50mcglactuation or puff: an aqueous suspension for metered dose nasal spray or inhalation. 120 doses (sprays) unit: 250.00 MRP

.:. LUTISONE Nasal Spray Incepta Fluticasone propionate BP 50mcglactuation or puff: an aqueous suspension for metered dose nasal spray or inhalation. 120 doses (sprays) unit: 250.00 MRP

.:. PERINASE Nasal Spray Beximco F1uticasone propionate BP 50mcglactuation or puff: an aqueous suspension for metered dose nasal spray or inhalation. 120 doses (sprays) unit: 250.00 IP

MOMETASONE71 MOMETASONE: Nasal Spray Mometasone furoate 50mcgl actuation or inhalation: aqueous suspension for metered dose nasal spray or. inhalation. Ind: Prophylaxis & treatment of seasonal or perennial allergic rhinitis. CII; SIE; Precaution: See above under the text of nasal corticosteroid preparations. Pregnancy & lactation: See above under the text of nasal corticosteroid preparations.

Dosage & Admin: Adults & Children 12 years ofage & older: The usual recommended dose


for prophylaxis and treatment is two sprays (50mcg/spray) in each nostril once daily (total dose 200mcg). Once symptoms are controlled, dose reduction to one spray in each nostril (total dose 100mcg) may be effective for matintenance. If symptoms are inadequately controlled, the dose may be increased to a maximum daily dose of four sprays in each nostril once daily (total dose 400mcg). Dose reduction is recommended following control of symptoms. Clinically significant onset of action occurs as early as 12 hours after the first dose.

Children between the ages of3 & 11 years: The usual recommended dose is one spray (50mcg/spray) in each nostril once daily (total dose l00mcg). In patients who have a story of moderate to severe symptoms of seasonal allergic rhinitis, prophylactic treatment with mometasone is recommended two to four weeks prior to the anticipated start of the pollen season. Shake container well before each use.

Note: For further information please consult manufacturer's literature.

.:. MOMESON Nasal Spray Incepta Mometasone furoate 50mcg/ actuation or inhalation: aqueous suspension for metered dose nasal spray or inhalation. 120 metered dose (spray) unit: 250.00 MRP

TRIAMCINOLONE21 ,35 TRIAMCINOLONE ACETONIDE: Nasal Inhaler Triamcinolone acetonide USP 0.7% w/w; each actuation or spray releases approximately 55mcg triamcinolone acetonide: nasal inhaler.

Ind: Allergic rhinitis, including hayfever, vasomotor rhinitis. CII; SIE; Precaution: See above under lhe text of nasal corticosteroid preparations.

Pregnancy & lactation: See above under the text of nasal corticosteroid preparations.

Dosage & admin: 4 actuations (220mcg) once a day & the effect be assessed in 4 to 7 days. If greater effect is desired an increase of dose to 440mcg (8 actuations) once a day can be tried. Although the preparations may be used at 220mcg/day or 440mcg/day divided into 2 or 4 times a day, the degree of relief does not seen to be significantly different compared to once a-day dosing. .:. CENOLON Nasal spray Incepta Triamcinolone acetonide USP 0.7% w/w; each actuation or spray releases approximately 55mcg triamcinolone acelonide: metered dose nasal inhaler. 120 sprays unit: 200.00 MRP

.:. TRISPRAY Nasal spray Square Triamcinolone acetonide USP 0.7% w/w; each actuation or spray releases approximately 55mcg triamcinolone acetonide: metered dose nasal inhaler. 120 sprays unit: 200.00 MRP

(Continuation from page-46)

in adults and children 4 years of age and older

Mode of action: Butamirate citrate is a centrally

pancytopenia, and alopecia.

chemically nor pharmacologically related to

levetiracetam may cause dizziness and

effect, butamirate also decreases the airway

advised not to drive or operate machinery or

dose is recommended in elderly patients with compromised renal function. Children aged 4 to 11 years & adolescents (12 to 17 years) weighing less than 50kg: The initial therapeutic dose is 10mglkg twice daily, Depending upon the clinical response and tolerability, the dose can be increased up to 30mglkg twice daily. Dose changes should not exceed increases or decreases of lOmglkg twice daily every two weeks. Dosage in children 50kg or greater is the same as in adults. Infants & children less than 4 years: Levetiracetam is not recommeded for use in children below 4 years of age due to insufficient data on safety and efficacy. Patients with renal & hepatic impairment: The daily dose must be individualised according to renal function. No dose adjustment is needed in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, the creatinine clearance may underestimate the renal insufficiency. Therefore a 50% reduction of the daily maintenance dose is recommended when the creatinine clearance is < 70mVmin. Over dosage: The highest known dose of

asthma patient.

have gained sufficient experience on

development program was 6000mglday. Other

cough, pre- and post-operative cough sedation for

affects their performance of these activities.

the few known cases of overdose in clinical

Anti-hypertensive: Diuretics .:. DIHERT SR Tab. Novartis

Indapamide 1 .5mgltablet (sustained release). 28's pack: 224.00 MRP

with epilepsy; 2. as adjunctive therapy in the

treatment of myoclonic seizures in adults and adolescents 12 years of age and older with

juvenile myoclonic epilepsy; 3. as adjunctive

therapy in the treatment of primary generalized tonic-clonic seizures in adults and children 6

years of age


& older with idiopathic generalized

epilepsy.

CII: Hypersensitivity to levetiracetam or any of

the inactive ingredients in levetiracetam tablets.

Cough suppressants BUTAMIRATE CITRATE .:. SINECOD Tab. SandozINovartis

Butamirate citrate BP 50mgltablet (sustained

SIE: Nausea, vomiting, dyspepsia, diarrhoea,

abdominal pain, anorexia, weight changes; couh;

drowsiness. asthenia, amnesia. ataxia, seizures, dizziness, headache, tremor, hyperkinesia,

depression, emotional lability, insomnia, anxiety, impaired attention, aggerssion, irritability;

thrombocytopenia; myalgia; visual disturbances;

release).

pruritus, rash; also reported pancreatitis, hepatic

suppressant preparation.

suicidal ideation, paraesthesia, leucopenia,

Butamirate citrate is a non sedative cough

acting cough suppressant which is neither

opium alkaloids. In addition to its antitussive

resistance and thereby facilitates respiration of

Ind: Butamirate citrate is indicated in acute dry

surgical procedures

& bronchoscopy. Butamirate

is also widely prescribed in productive cough

along with antibiotic or chemotherapeutic agent

dysfunction, confusion, psychosis, hallucinations,

Precautions: Patients should be advised that somnolence. Accordingly, patients should be

engage in other hazardous activities until they levetiracetam to gauge whether it adversely

Patients should be advised that levetiracetam may cause changes in behavior (e.g aggression,

agitation, anger, anxiety, apathy, depression,

for faster cough suppression.

hostility, and irritability) and in rare cases

can be given in pregnancy if the benefits

and/or suicidal ideation.

levetiracetam received in the clinical

than drowsiness, there were no adverse events in

trials. Cases of somnolence, agitation, aggression, depressed level of consciousness, respiratory depression and coma were observed with

levetiracetam overdoses in postmarketing use. If

Pregnancy & lactation: Butarnirate citrate only

patients may experience psychotic symptoms

indicated, elimination of unabsorbed drug should

overweigh the potential risks.


precautions should be observed to maintain

Dosage & admin: Children of 5-10 years, 1-2 tablets daily; Children over 10 years & adults, 2-3 tablets daily irrespective of food intake. Usual duration 5-7 days. However, butamirate citrate can be prescribed up to 2 months in chronic diseases. Butamirate citrate is safe in extremes of ages. Note: For further information, please consult manufacturer's literature. 50's pack: 300.00 MRP


Anti-epileptic drugs LEVETIRACETAM .:. ERATA Tab. Novartis

Levetiracetam INN 250mg coated).

& 500mgltablet (film

Levetiracetam is an antiepileptic drug chemically unrelated to existing antiepileptic drugs (AEDs).

Ind: Levetiracetam is indicated- 1. as adjunctive

therapy in the treatment of partial onset seizures

data from the use of levetiracetam in pregnant

women. Levetiracetam should not be used during

pregnancy unless clearly necessary.

be attempted by emesis or gastric lavage; usual airway.

Drug inter: Phenytoin: Levetiracetam (3000mg

daily) had no effect on the pharmacokinetic

Discontinuation of antiepileptic treatments may

disposition of phenytoin in patients with refractory

be harmful to the mother and the foetus.

also not affected by phenytoin.

result in exacerbation of the disease which could Levetiraetam is excreted in human breast mille Therefore, breast-feeding is not recommended.

Dosage & admin: Monotherapy: Adults & adolescents from 16 years ofage: The recommended starting dose is 250mg twice daily which should be increased to an initial therapeutic dose of 500mg twice daily after two weeks. The dose can be further increased by 250mg twice daily every two weeks depending upon the clinical response. The maximum dose is 1500mg twice daily. Adults & adolescentrs (12-17 years) weighing 50kg or more: The initial therapeutic doses is 500mg twice daily. This dose can be started on the first day of treatment. Depending upon the clinical response & tolerability, the daily dQse can be increased up to 1,500mg twice daily. Dose changes can be made in 500mg twice daly increases or decreases every 2 to 4 weeks. Elderly (65 years and older): Adjustment of the

epilepsy. Pharmacokinetics of levetiracetam were

Va/proate: Levetiracetam ( l5OOmg twice daily)

did not alter the pharmacokinetics of valproate in

healthy volunteers. Valproate 500mg twice daily

did not modify the rate or extent of levetiracetam absorption or its plasma clearance or urinary

excretion.

Potential drug interactions between levetiracetam and other AEDs (carbamazepine, gabapentin,

lamotrigine, phenobarbital, phenytoin, primidone

and valproate) were also assessed by evaluating the serum concentrations of levetiracetam and

these AEDs during placebo-controlled clinical studies. These data indicate that levetiracetam

does not influence the plasma concentration of

other AEDs and that these AEDs do not influence the pharmacokinetics of levetiracetam.


250mg x 30's pack: 480.00 MRP

500mg x 30's pack: 900.00 MRP

MISSING DRUGS (Continuation/rom page-In)

QIMP-15 (435)

dysmenorrhoea; migraine; post-operative

gastrointestinal hemorrhage, ulcerative colitis.

the next dose, skip the missed dose and continue regular dosing schedule_ Do not take a double dose to make up for a missed one. Drug inter: Care should be taken in patients

Bronchospasm and other hypersensitivity-type

treated with any of the following drugs as

reactions with aspirin and other non-steroidal

interactions have been reported in some patients

analgesia, dental pain; relief of sore throat.

CEFUROXIME .:. CEFORE Tab_ Chemico & 500mgltablet (f.c).

Cefuroxime axetil 250mg

250mg x 16's pack: 400.00 MRP 500mg x 8's pack: 360.00 MRP

(Continuation from page-24S)

ACECLOFENAC .:. ACN Tab. Modern Pharma Aceclofenac BP l 00mgltablet (f.c). l 00's pack: 300.00 MRP

FLURBIPROFEN34

CII: Active peptic ulceration or recent

agents. Relative contraindications are anticoagu

antihypertensives, diuretics, cardiac glycosides,

lant therapy, diuretic therapy and patients with

lithium, methotrexate etc.

history of heart failurelhypertension and non

30's pack: 150.00 MRP

allergic asthma. Patients with a prior hypersen sitivity to flurbiprofen or any other ingredient in the formulation.

SIE: The most important side effects are peptic ulceration, hemorrhage and perforation. Gastrointestinal adverse effects include dyspepsia, nausea, vomiting, constipation and diarrhea. There may be peripheral edema due to salt and water retention. Some neurological reactions such as dizziness, tinnitus, deafness and blurred vision have been reported which have

: URBIFEN Tab. General

•.

F1urbiprofen BP 50mg/tablet (film-coated). F1urbiprofen is a potent non-steroidal anti inflammatory drug with antipyretic and analgesic activity.

Mode of action: Flurbiprofen is a cyclooxygenase inhibitor. It inhibits prostaglandin and thromboxane biosynthesis. It inhibits vasodilatation and also prevents the sensitization of pain fibers by prostaglandins.

Ind: Pain and inflammation in rheumatic disease and other musculoskeletal disorders such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, frozen shoulder, low back pain, sprains & strains; mild to moderate pain including

disappeared on withdrawal of the drug.

Precautions: Flurbiprofen has not been extensively studied in children. If is not recommended for children under 1 2 years of age.

Pregnancy & lactation: The safety of flurbiprofen during pregnancy has not been established. Breast feeding is not contraindication

(Continuation from page-303) .:. LISTER COOL MINT Mouthwash General Lister cool mint is a preparation for antiseptic mouthwash. It is available as solution in 120ml & 250ml bottle.

Comp: Lister cool mint antiseptic mouthwash is composed of- methyl salicylate 0.060%, eucalyptol 0.092%, menthol 0.42%

& thymol

0.64% .

Ind. & use: Lister cool antiseptic mouthwash & reduces plaques & gingivitis; fights

prevents

against bad breath; kills germs between teeth, controls tartar that can discolour teeth, keep teeth cleaner

& brighter. Precautions: It should not be allowed to use

below 12 years of age. Keep outside the reach of

but safety is not declared.

children.

Dosage: 150-200mg daily in divided doses, increased in acute conditions to 300mg daily. In dysmenorrhoea, initially lOOmg, then 50100mg every 4-6 hours; maximum 300mg daily. Missed dose: Take the missed dose as soon as remembered. However, if it is almost time for

Use & admin: Gargle 20ml (4 isO of full strength solution for 30 seconds, then remove it, and must not be swallowed. Use two times everyday in the morning & night. 1 20ml bot: 75.00 MRP 250ml bot: 140.00 MRP

QIMP·15 (III)

CONTENTS QIMP

(!)

Preface

(!)

References

(!)

Index

(!)

Sectional Therapeutics (Chapter:

(!)

Qu,ck Iridexof Medical Products & Problems

1-21)

IX

1 434 437

Section-3 Research & Development

(!)

IV

Section-2 Indigenous Medicines

(!)

I

Chapter- 22 Missing Drugs

(!)

Page

447

Section-4 Appendices:

1.

Physiological Norms & Values (Blood, C.S.F Urine)

457 457

460

2.

Nomlal Vaues in Liver Function Tests

3.

C.S.F Picture in Different Diseases

4.

Urine Tests for Diabetes

5.

461

Important Radiological Procedures

462

6.

EDD & Obstetric Table

7.

Comparison of Breast Milk and Whole Cow's Milk

8.

Infectious Diseases Table

9.

Immunization Schedule

10.

11.

12.

Pharmaceutical Company Directory Doctors addresses & Telephone guide Leading private Hospitals & Clinics in Mega Cities of Bangladesh

461

462

463 463

464

465

470 503

Indices:

1.

Alphabetic T herapeutic Index

505

QIMP-15 (437)

Section

-

2

INDIGENOUS ANTACID, ANTI-DYSPEPTIC & CARMINATIVE PREPARATIONS

function, dyspepsia, flatulence, diarrhoea,

.:. ELZYNE Syp. Jayson Natural55

constipation etc.

It is a herbal antidyspeptic, antidysenteric

CII: Should not use in dysentery & ulcer Dosage: Adult - 2 tabs. 2-3 time daily after meals. Child. 1 tab. twice daily after meals.

antidiarrhoeal preparation.

60 tabs. pack: 40.00 MRP

:. CARMINA Syp. Hamdard38

•

Each 5ml syrup contains- piper nigrum l S Omg,

.:. ACMINA Syp_ Acme46 Acmina is a combination of some effective herbs that has canninative, stomachic and antioxidant properties. It strengthens immune-system and promotes secretion of saliva, gastric juices and bile. It is available as 200ml syrup in glass bottle.

Camp: Each Sml contains extracts of- Cyperus rotundus 2.63gm, Woodfordia fruticosa 0.22gm, Zingiber officinale 27.3Smg, Piper nigrum 27.3Smg, Syzygium aromaticum 27.3Smg, Trigonella foenum-graecum 27.3Smg, Plumbago zeylanica 27.3Smg and Cuminum cyminum 27.3Smg.

Ind: It is used for anorexia, dyspepsia, flatulence, dysentery and other gastrointestinal problems. It is safe and effective medicine for all ages of both male

INDIGENOUS MEDICINES

& female patients.

CII: Not yet known. SIE: There is no known significant side effect. Pregnancy & lactation: No restriction known. Dosage & admin: Adult: 2-4 tsf 1-2 times daily after meal, or as advised by the physician. Children under 12 years: 1-2 tsf. 1-2 times daily after meal. 200m I bot: 40.00 MRP

.:. ALPRO Syp. Deep-Laid l 42 & digestant syrup. Compo Each Sml contains: Ptychotis ajowan,

Alpro is a natural enzyme

Alpinia glanga, Flacortia calaphracta, Curcuma zedoaria.

Ind: Anorexia, indigestion, flatulence, stomach & intestinal weakness.

CII: No contraindication has been reported. Dosage: 3 tsf 2-3 times daily. 100ml bot: 2S.00 MRP 450ml bot: 65.00 MRP

:. CARMINA Tab. Hamdard38

•

Each tablet contains- piper nigrum 60mg,

trachyspennum ammi 1 00mg, citrus aurantifolia 1 00mg, cinnamomum zeylanicum 50mg, emblica officinalis 50mg, terminalia bellerica 38mg, tenninalia chebula 3Smg, zingiber officinale l Omg; sea salt Smg.

Ind & C1I: See under Carmina tablet preparation.

Compo Each 5ml contains- cyperus rotundus 3 .S4gm, zingiber - O.04gm, piper nigrum O.04gm, syzygium aromaticum - O.04gm, trigonella foenum gracum - O.04gm, plumbago zeylanica - O.04gm, cuminum cynimum - O.04gm.

Ind: Dyspepsia, anorexia, gastro-intestinal troubles.

Caution: Peptic ulcer, avoid intake in an empty stomach.

Dosage: Adult, 2·3 tsf thrice daily. Children, 6· 12 yrs 1·2 tsf thrice daily. Duration of use· 1 to 3 weeks. 100ml bot: 20.00 MRP

Dosage: Adult - 2 tsf 2-3 time daily after meals. Child· 1 tsf twice daily after meals.



A very effective preparation of gum mastic

225ml bot: 45.00 MRP 450ml bot: SO.OO MRP

.:. CARMOLIN Syp. A.H Janakalyan38•64 Each 5ml syrup contains- piper nigrum 1 50mg, trachyspennum arumi l 00mg, citrus aurantifolia 1 00mg, cinnamomum zeylanicum 50mg, emblica officinalis 50mg, tenninalia bellerica 3Smg, tenninalia chebula 38mg, zingiber officinale lOmg; sea salt Smg.

Ind: Digestive disorder due to impainnent of live

450m1 bot: 60.00 MRP

.:. ENDEMALI Sachet Hamdard38 (Roomi mastagi), Psyllium (Isphaghul) and other herbal ingredients for peptic ulcer & hyperacidity.

Compo Each sachet contains: Plantago ovata (Husk) 0.S7gm, Ocimum sanctum 0.5Sgm, Pistacia lentiscus O.5Sgm, Vateria indica 0.15gm, other ingredients q.s.

Ind: Hyperacidity, gastritis and peptic ulcer, flatulence, dysentery, constipation.

C1I: There is no known contraindication. SIE: No significant side effect has been observed

function, dyspepsia, flatulence, diarrhoea,

in proper dosage.

constipation etc.

Dosage: Each sachet twice daily before meal with water, atIeast 1 month or as prescribed by the physician. For peptic ulcer and hyperacidity, 1 sachet twice a day before meal with half glass of water. In dysentery, 1 sachet 4 times a day and for constipation 1 sachet at bedtime with plenty of water.

CII: Should not use in dysentery & ulcer Dosage: Adult - 2 tsf 2·3 time daily after meals. Child· 1 tsf twice daily after meals. lOOml bot: 2S.00 MRP 250ml bot: 50.00 MRP 4S0ml bot: 90.00 MRP

.:. DIGAC Syp. Acme46 Digac syrup is a herbal digestant preparation. It's generic name is jamani arka.

Compo Each 5ml contains- Trachyspennum arumi 0.93gm.

Ind: Indigestion, dyspepsia, flatulence, colic and constipation. CII: There i s no absolute contraindication.

AIR:

Not yet known.

20 sachets pack: 200.00 MRP

.:. GASTO-4 Syp. Jayson NaturalSS A herbal antacid preparation with anti-dyspeptic action.

Com: Each 5ml contains- emblica efficinalis l 25mg, tenninalia belarica 125mg, tenninalia chebula 125mg, adhatoda vasica 1 2Smg, tinospora cordifolia 125mg, margosa indica 125mg, swertia chirata 1 25mg, oldenlandia corymbasa 1 25mg.

4mg; sea salt 1 6mg.

Dosage & admin: Adult: 2·4 tsf with equal quantity of water to be taken 2·3 times daily after meal. Children: 1-2 tsf with equal quantity of water to be taken 2-3 times daily after meal.

Ind: Digestive disorder due to impainnent of live

1 00ml bot: 20.00 MRP

to cause any side-effect.

trachyspennum ammi 40mg, citrus aurantifolia 40mg, cinnamomum zeylanicum 20mg, emblica officinalis 20mg, tenninalia bellerica 1 5mg, tenninalia chebula 15mg, zingiber officinale

&

Ind: Hyperacidity, heartburn, dyspepsia and flatulence.

CII: There is no known contraindication. SIE: This preparation has yet not been reported

QIMP-15 (438)

INDIGENOUS MEDICINES Caution: This syrup should be used with caution

such as indigestion, diarrhoea, griping, flatulence;

Ind: Diarrhoea, dysentery, chronic dysentery

in the first trimester of pregnancy.

teething troubles; convulsions.

haemorrhagia.

Dosage: Up to 6 months, 1/2 tsf; 6 month-1 year, 1 tsf; 1-2 years, 2 tsf; all are thrice or four times a day.

CII: No contraindications. SIE: No side-effect. Dosage: Adult: 2-4 tablets 2-3 times daily. Children: 1-2 tablets 2-3 times daily. Pharmaceutical precaution: Store in a cool dry place.

Dosage: Adult- 3 to 4 tsf thrice daily, half an hour after food. Children: 1-2 teaspoonful thrice daily half an hour after food. This syrup to be used for 2-4 weeks. It can be taken as it is, or slightly diluted with a little water. Drug inter: No drug interactions have been known. 200ml bot: 36.00 MRP

.:. HD-ZAINARQ Syp. Jayson Natural55 It is a herbal digestant preparation.

Com: Each SmI containsPtychotis ajowan 1 .2Smg.

Ref: Jamai ark B.N.A.F. lnd: Indigestion, fermentative dyspepsia, loss of appetite and constipation

C/I: Zainarq should not be given to patients with

diarrhoeal conditions.

SIE: No side-effects has been experienced yet. Dosage: Adult- 2 to 3 tsf thrice daily, after meals. Children: 1 tsf thrice daily after meals. Dosage may be adjusted in case of acute dyspepsia up to a maximum 3 to 4 tsf thrice daily before meals and after meals. The duration is 7 to 14 days. Pharmaceutical precaution: Sediment is the part of the medicine. Store in a cool dry place. Shake well before use.


.:. DEFLIN Syp. Deep-Laidl 42 Detlin is a baby carminative syrup. This natural formulation is completely safe for children.

Comp: (Not availed). Ind: Flatulence, indigestion, abdominal pain,

diarrhoea & symptoms during teething.

C/I:

Dosage: Child up to 4 months: 10-20 drops 3-4 times daily. Above 4 months: 1/2 tsp to 3 tsp thrice daily. lOOml bot: 30.00 MRP

.:. NAUNEHAL Syp. Hamdard38 A herbal baby carminative; an effective homely remedy for infants and children with digestive disorders, teething problems and as a prophylactic against these common maladies.

Ind: Digestive disorders in infants and children, such as indigestion, diarrhoea, griping, flatulence; teething troubles; convulsions.

Dosage: Up to 6 months, 1/2 tsf; 6 month-1 year, 1 tsf; 1-2 years, 2 tsf; all are thrice or four times a day. l OOml bot: 28.00 MRP

ANTI-DIARRHOEAL &

l OOml bot: 22.00 MRP 200ml bot: 40.00 MRP

ANTI-DYSENTERIC

4S0ml bot: 7S.00 MRP

INDIGENOUS BABY CARMINATIVE PREPARATIONS

No contraindication has been reported.

PREPARATIONS .:. ADAD Syp. Deep-Laid l42 Anti-diarrhoeal and anti-dysenteric syrup. It is produced from raw aegle marmelos and other anti-dysenteric natural ingredients. Adad controls diarrhoea fast by its anti-spasmodic activity.

.:. ANISOL Syp. Jayson NaturalS5 A herbal baby carminative preparation.

Com: This carminative preparation is composed of- pimpinella anisum, anethum sowa seeds, elettaria cardamomum. mentha piperita, anise oil, hordcum vulgare.

Ind: Indigestion, flatulence, gastrointestinal troubles of the infants and babies during teething.

CII: No contraindications are reported. SIE: No side effect yet reported or experienced in recommended doses.

Dosage: 0-6 month: 1/2 tsf 3 to 4 times daily. 6-12 month: 1 tsf 3 to 4 times daily. 1-2 years: 1 to 2 tsf 3 to 4 times d;'i1y. Or as directed by the physician. Pharmaceutical precaution: Medicinal herbs and plants extract used in Anisol. So may be sediment on prolonged store. Shake well before use and store in a cool dry place.

Comp: Each Sml contains: Aegle marmelos, Holarrhena antidysenterica and other ingredients.

lnd: Diarrhoea, amoebic dysentery, intestinal spasm.

Ind: Digestive disorders in infants and children,

CII: No contraindications. SIE: No side-effect. Dosage: Adult: 4 tsf 3 times daily with water. Children: 1-2 tsf 3 times daily 7-14 days. Pharmaceutical precaution: Store in a cool dry place. l OOml bot: 35.00 MRP

.:. MARBELUS Syp. Hamdard38 Marbelus is a unique combination of aegle marmelos (bel) & holarrhena antidysenterica (kurchi) which is highly effective in diarrhoea, amoebiasis, bacillary dysentery (shigellosis), giardiasis & helminthiasis.

Comp: Each Sml syrup contains (as aq. extracts): Aegle marmelos (dry unripe bel fruit) 1 .0mg.

Ref: B .N.U.F. Ind: Diarrhoea, amoebiasis, bacillary dysentery, giardiasis, helminthiasis, irritable bowel syndrome (IBS), gastroenteritis. dyspepsia, indigstion & flatulence, peptic ulcer & hyperacidic complication.

CII: There is no known contraindication. SIE: Marbelus is well tolerated & safe for both

children & adults. No significant side effects has

been observed in proper dosage.

Dosage & admin: Adults: 2 tsf (10ml) 3-4 times daily. Children: 1 tsf (Sml) 3-4 times daily or as prescribed by the physician. l OOml bot: 33.00 MRP 225ml bot: SO.OO MRP

.:. PAICHISH Tab. Hamdard38

gastrointestinal colic .

It is a herbal anti-dysenteric & anti-diarrhoeal preparation.

Ind: Amoebic & bacillary dysentery, chronic

It is a herbal antidysenteric, antidiarrhoeal &

lnd: Dysentery, blood dysentery, diarrhoea & Dosage: Adults, 2 tablets twice or thrice a day. Children (6-12 years), 1 tablet twice or thrice a day.

dysentery and diarrhoea.

l OO's pack: 1 80.00 MRP

CII: No contraindications. SIE: No side-effect. Dosage: Adult: 4 tsf 3 times daily with water. Children: 1-2 tsf 3 times daily 7-14 days. Pharmaceutical precaution: Store in a cool dry place.

.:. SAFFODIN Tab. A.H Janakalyan38•64

100ml bot: 2S.00 MRP 450ml bot: 90.00 MRP

.:. DYROTAB Tab. Jayson NaturalS5

prophylactic against these common maladies.

lnd: Amoebic & bacillary dysentery, chronic dysentery and diarrhoea.

:. DYROMA Syp. Jayson Natural55

•

Each tablet contains- punica granatum 7S.00mg,

disorders, teething problems and as a

preparation.

antispasmodic preparation.

60ml bot: 25.00 MRP

.:. BABICA Syp. A.H Janakalyan38,64 A herbal baby carminative; an effective homely

.:. LOMOSIS Syp. A.H Janakalyan55 It is a herbal anti-dysenteric & anti-diarrhoeal

CII: No contraindication has been reported. Dosage: lOmI 2-3 times daily.

1 00m1 bot: 23.00 MRP

remedy for infants and children with digestive

100's pack: 1 40.00 MRP

It is a herbal antidysenteric, antidiarrhoeal & antispasmodic preparation.

Ind: Dysentery, blood dysentery, diarrhoea &

gastrointestinal colic.

Dosage: Adults, 2 tablets twice or thrice a day. Children (6-12 years), 1 tablet twice or thrice a day. 12's pack: 48.00 MRP 50's pack: 200.00 MRP

bolus armenia rubra 7S.00mg, gum acacia arabica 7S.00mg, rosa damascena 56.2Smg, acacia arabica S6.25mg, cochlospermum religiosum 37.S0mg.

Ref: Qurs Gulnar, B.N.U.F.

HERBAL LAXATIVE PREPARATIONS


QIMP-15 (439)

.:. ISPAGHOL (HUSK) Sachet Hamdard38 Pure and clean, well preserved in laboratories psyllium (Ispaghol) is a mild laxative, diuretic and demulcent and soothing for the gastric and intestinal mucosa and hence effective in gastric irritation and ulceration. Very useful in chronic amoebic dysentery, chronic constipation and piles. Due to its inherent anaesthetic properties, it relieves gastric or peptic ulcer pain and chronic diarrhoea.

Comp: Each sachet contains: Plantago ovata (Husk) 3.50gm.

Ind: A natural herbal treatment for gastric irritation and ulceration, chronic dysentery, chronic costipation and piles.

Dosage: One sachet before breakfast or before bed time with one glass plain water.

CII: There is no known contra indication. S/E: No significant side effect has been observed.

Precaution: Drink plenty of water during taking ispaghol.

elettaria cardamomum, ambergris etc.

3 doses, or as directed by the physician_

Ind: Hepatic dysfunctions, sluggish liver &

Drug inter: The concomitant use of silymarin

anaemia; also useful in general debility. It is a

and butyrophenones or phenothiazines results in

good cardiac tonic too,

a reduction of Iipild peroxidation.

if used with

jawabar

mohra (powdered pearls and precious stones).

Dosage: For cardiac weakness, 1 tsf once daily. For gastric and liver weakness, 1 tsf given with 4 tsf arq. mouUaham_ Children: 4-6 years, 114- 112 tsf once daily for

1-2 months or as advised by the physician_ If needed for longer use, give 1 week interval after every 2-3 weeks medication. 50gm pack: 300.00 MRP

.:. DINAR Syp. Hamdard38 It is a herbal preparation for liver disorders and protection of liver functions.

Comp: Cichorium endivia, cuscuta reflexa, rheum emodi etc.

Ind: Hepatitis, obstructive jaundice, ascites, constipation; pleurisy

& alveolitis.

Dosage: Adults, 2-3 tsf & children, 1/2 -1 tsf twice daily after meal.

25 sachets pack: 135.00 MRP

PREPARATIONS .:. DEMORHOID Cap_ Deep-Laid l42

& curative for

piles. It is an oral therapy for piles & fistula.

Comp: Each capsule contains: Terrninalia chebula, Berberis aristata, and other ingredients.

Ind: Piles, Fistula, Constipation. CII: No contraindication has been reported. Dosage: 1-2 capsules twice daily. 50's pack: 200.00 MRP

:.

•

HEPA-10 Syp. Jayson Natural55 It is a herbal preparation for liver disorders and associated clinical manifestations.

Comp: Each 5m! syrup contains- andrographis paniculate 100mg, apium graveolens 300mg,

Rec is a herbal ointment for piles decreases the lump of piles

longifolia lOOmg, cassia fistula 150mg, cichorium endivia 15Omg, foeniculum vulgare 150mg, leonurus cardiaca lOOmg, teminalia chebula l OOmg, trianthema portulacastrum 100mg.

Ind: Hepatitis, jaundice, congestion of the liver & biliary tract; severe oedema & acne vulgaris due to liver disturbances; habitual constipation, chronic

& drug induced g.i troubles. It promotes bile production & secretion of milk in lactating mothers .

REC Oint. Deep-Laidl 42

& fistula. It

& removes swelling

Caution: Fat containing diets should be avoided during treatment. Liver

& kidney damage;

and pain of anus.

pregnancy, neonates.

Comp: Each 5gm contains: Azadirachta indica

Dosage: Adult, 2-4 tsf twice daily; children 6-

"Oil", Boric acid BP, Galic acid BP and other

12 yrs 1-2 tsf twice daily, 2-5 yrs 1/2-1 tsf twice daily, 0-2 yrs 114-112 tsf twice daily. To be given for 3-5 weeks_

ingredients.

Ind: Local use for piles & fistula, swelling & pain of anus.

100m! bot: 2 1 .00 MRP

CII: No contraindication has been reported.

200m! bot: 39.00 MRP

Dosage: Apply slight ointment to external or inner site of anus with applicator. 20gm tube: 65.00 MRP

FOR LIVER DISORDERS .:. DAWA-UL-MISK Syp. Hamdard38

Aphanamixis polystachya 1 .52gm, woodfordia fructicosa 0.24gm, emblica officinalis 15.24mg, terrninalia chebula 1 5.24mg, terrninalia belerica 15.24mg, zingiber officinale 15.24mg, piper longum (root) 15.24mg, piper longum (fruit) 1 5.24mg, elettaria cardamomum 1 5.24mg, cinnamomum tamala 15.24mg, cinnamomum zeylanicum 15.24.

Ref: Rohitakarista, BNAF.

S/E: Not yet known .

Dosage & admin: Adult: 2-4 tsf 2-3 times daily after meal_ Children: 1-2 tsf 2-3 times daily after meal. Or, as directed by the physician. 200m! bot: 35.00 MRP

.:. HEPAZIN Syp_ A_H Janakalyan38•64 It is a herbal preparation for liver disorders and protection of liver function.

Comp: It is a herbal preparation. It's main ingredients are- Cichorium endivia, Rosa damascena, Borago officinalis, Cuscuta reflexa etc.

Ind: Hepatitis, obstructive jaundice, ascites, pleurisy, constipation.

Dosage: Adults, 2-3 tsf thrice daily. Children, 112-1 tsf thrice daily. 250m! bot: 60.00 MRP 450ml bot: 100.00 MRP

.:. HETRO Syp_ Deep-Laidl" Hetro is a unique herbal formulation for promoting hepato-biliary system. It develops bile promoting hepato-biliary system. It enhences bile production, improves metabolism.

Comp: Each 5m! contains: Cichorium intibus (Root), Cichorium intibus (seed), Rosa

.:. HEPAMILK Cap. Acme46 Silymarin, a flavonoid complex of mille Thistle

Cuscuta reflexa, Rheum emodi.

is the biologically active component. It provides

anorexia, constipation.

at the membrane level, enhanced protein synthesis, antioxidant activity, antifibriotic activiry, and possible anti-inflammatory or immunomodulating effects.

It is a herbal preparation for hepatic

Comp: Each 5m! syrup contains extracts of the following herbal ingredients:

450m! hot: 72.00 MRP

hepatocellular protection through toxin blockade

HERBAL PREPARATIONS

syrup in 200ml bottle.

C/I: There is no absolute contraindication.

:.

•

artemisia absinthium l OOmg, asteracantha

Demorhoid is a herbal preventive

It has also digestive and anti-oxidant activity. It is also known as rohitakarista. It is available as

chronic indigestion, anorexia.

450m! bot: 80.00 MRP

HERBAI.J ANTI

.:. HEPATOLIN Syp. Acme46 Hepatolin is a hepatoprotective herbal medicine.

Ind: Jaundice, hepatitis, toxic liver injury;

1 00m! hot: 25.00 MRP

HAEMORRHOIDAL

20's pack: 100.00 MRP

Comp: Each capsule contains milk thistle

damasecena, Nymphaya lotus, Borago officinalis,

Ind: Jaundice, hepatitis, liver function dsorder, CII: No contraindication has been reported. Dosage: Adults, 2-3 tsf & Children, l/Z - 1 tsr twice daily_ lOOml bot: 25.00 MRP 450m! bot: 70.00 MRP

87.5mg equivalent to 70mg silymarin.

.:. ICTEREN Tab. Hamdard38

Ind: Adjunctive treatment in chronic

Icterene is effective in the treatment of hepatic

dysfunctions and cardiac strength.

inflammatory liver disease (i.e viral or alcoholic

and biliary disorders, specially jaundice.

Comp: A well-known herbal preparation in

hepatitis), hepatic cirrhosis, toxic liver damage etc.

The inorganic chemical compound which has

sucrose and honey. Main ingredients are berberis aristata, bambusa arundinacea, coriandrum

C/I: No

significant contraindication is observed.

been obtained from

tamarix dioica is found to be

S/E: A mild laxative effect has been observed in

very much effective in the hepatic disorder

sativum, onosma bracteatum, emblica officinalis,

occasional instances.

specially iaundice, haemolysis as well as

coral roots, silver leaves, rosa damascena,

Pregnancy & lactation: No restriction known.

infection. Extensive clinical trials have

cinnarnomum zeylanicum, salvia haematodes,

Dosage & admin: 2-4 capsules divided in 2 to

established icterene as the only known effective

QIMP·IS (440)


drug for the hepatic and biliary disorders.

SIE: No significant side effect has been observed

Icterene improves the hepatic functions, acts as a

in proper dosage.

diaphoretic and diuretic too.

Precautions: Jigarine should be preserved from

Comp: Each tablet contains: Salt of tamarix

dampness and direct sunlight. In liver diseases

dioica 530mg, and other ingredients q.s.

light food should be taken. Plenty of liquid,

Ind: Icterene is indicated in jaundice, haemolysis and infection. It is also indicated in jaundice

lemon juice and the use of juicy fruits are suggested.

neonatorum. It has also been successfully

Dosage & admin: Hepatic congestion &

employed in oliguria and wherever diuresis is

hepatitis: 2 strips of jigarine, 1 in the morning

required. In mild infective febrile states, icterene

and 1 in the evening should be taken. If the

acts as a diaphoretic and lowers the body

liver is harden due to gross inflammation, 1

temperature.

tablet of icterene should he taken along with

CII: There is no known contraindication.

jigarine.


Sluggish liver: In sluggish liver which creates

in proper dosage.

many digestive troubles when appetite

Precaution: Plenty of drinks, glucose water, fruit

disappears, fresh blood is not formed and the

juices should be taken during the course of

face becomes pale, only one dose in the

treatment. Meat and fats to be avoided totally

morning or evening is enough. Two doses with

during the treatment.

lunch and dinner quickly restores the normal

Dosage & admin: Adults: Usually 2 tablets 3

blood formation. In some such cases dawaul

times daily for 3 days are enough to bring

misk, motadil jawahirdar should be taken

about a therapeutic cure, but in severe cases 8

alongwith jigarine.

tablets in 24 hours can be given in divided

Enlarged liver and heptalgia: Only one strip is

doses without any harm. In children, the

enough in the morning or at bedtime.

dosage may be reduced according to the age.

Liver cirrhosis: In some hepatic cases when

In case where satisfactory response has not

due to excessive use of alcohol, there appear

been obtained, further course for 3 days may

cirrhotic symptoms, the continuous use of

be given to the patient with the usual dosage

jigarine is very helpful. It retards the process

schedule.

of cirrbosis (hardening of liver).

If the effective results are not yet

obtained, investigations should be immediately

25 strips pack: 460.00 MRP

initiated for obstructive jaundice.

Ictum is an effective herbal preparation for liver disorders containing Borago officinalis

HERBAL APPETITE STIMULANTS

(Gaozaban), Cichorium endivia, Cuscuta reflexa, Rheum emodi etc. Gaozaban contains gama linolic acid which is highly effective in all types of inflammation including hepatitis. Kashni is very effective in jaundice. It is available as syrup in 1 00ml & 450ml glass bottle.

Comp: Each 5ml contains: Cichorium intybus (root) 400mg, Cichorium intybus (seed) 200mg, Rosa damascena 200mg, Borago officinalis lOOmg, Cuscuta reflexa l50mg, Nymphaea nouchali lOOmg, Rheum emodi 1 25mg. (Ref: Sharbat Deenar)

Ind: Hepatitis, jaundice, ascites, pleurisy, alveolitis, uterine inflammation & constipation.

CII: There is no known contraindication. SIE: No significant side effect has been observed in proper dosage.

Dosage: Adults: 2·3 tsf twice daily. Children: 112·1 tsf twice daily or as directed by the physician.

& BLOOD PRESSURE LOWERING PREPNS.

GARLIC PREPN38.55 GARLIC PREPN: Tablet/Capsule/Syrup Garlic, a herbal preparation for lowering blood lipid level & high blood pressure, thus helping in maintaining good health. It is available as capsule, tablet & syrup form.

Comp: Tablet: Each garlic tablet contains· allium sativum 350mg, allium cepa 25mg, & zingiber officinale 41 .66mg. The ingredients which are essential for sound health, like vitamin B and C, mineral salts, sulphur and volatile oil, all found in garlic tablets and well preserved.

Capsule: Please see the manufacturer's literature. Syrup: Each 5ml contains· allium sativum 300mg, allium cepa 100mg, anacyclus pyrenthrun 100mg, syzygium cumini IOOmg, piper nigram 0.75mg, ruta graveolens 0.75mg.

Ind: High blood pressure, hypercholesterolemia, hyperlipidemia, rheumatism, nervous & general debility for stamina, cold and cough, bronchitis and abdominal disorders. CII: Children and high temperament patient.

SIE: No toxicity was observed.

30 tabs pack: 400.00 MRP

.:. ICTURN Syp. Hamdard38

BLOOD LIPID LEVEL

Dosage: Tablet/capsule· 1 tablet or capsule after meals 2 to 3 times daily. 2 tablets or capsules twice a day after meals are effective in cold and chest congestion. For gastro· intestinal ailments one garlic tablet or capsule,

HAJMO.A Tab. Acme46 Hajmo·A tablet is a herbal appetizer preparation. It's generic name is vaskor laban.

Comp: Each tablet contains· Piper longum (seed), Coriandrum sativum, Nigella sativa, Cinnamomum tamala, Flacaurtia jangomas, Mesua ferrea, Piper nigrum, Cuminum cyminum, Zingiber officinale, Cinnamomum zeylanicum, Amomum sublulatum, Punica granatum, Remex vesicarius, Sodi chloridum, Bit salt, Sachal salt and Sodium chloride.

one hour before meals. Syrup· 3 to 4 tsf 3 times daily with a cup of water before or after meals.

.:. GARLIC Tab. Hamdard A herbal garlic preparation: tablet

Comp: See above under the text. 60's pack: 46.00 MRP

.:. GARLICON Syp. Jayson Natural A herbal garlic preparation: syrup.

Comp: See above under the text.

Ind: Loss of appetite, flatulance.


C1I: There is no absolute contraindication. AIR: Not yet known. Dosage & admin: Adults: 2 tablets daily.

.:. JANAKALYAN GARLIC Tab. A.H Janakalyan

Children: 1 tablet daily.


25 tabs pack: 10.00 MRP

.:. HAZMOTAB Tab. Jayson Natural55

A herbal garlic preparation: tablet 12's pack: 36.00 MRP 50's pack: 150.00 MRP


Each tablet contains· piper nigrum 24.02mg,

.:. LOPID Cap. Acme


zingiber officinale 24.02mg, syzygium

A herbal garlic preparation: capsule

.:. nGARINE Strip. Hamdard38 Jigarine is a combination of aqueous extracts of yarrow (Achillea millefolium) & wormwood (Artemisia absinthium), effective in the treatment for hepatic disorders like hepatitis, hepatalgia, enlarged and sluggish liver. This may be taken as a whole with hot water or dissolved in hot water.

Comp: Each strip contains: Dry extract of Achillea millefolium 1 .56gm & dry extract of Artemisia absinthium 1 .56gm.

Ind: Hepatic congestion and hepatitis, sluggish

aromaticum 8.00mg, lake salt 59.95mg, other


ingredients Q.S.

30's pack: 150.00 MRP

Ind: Indigestion, dyspepsia, anorexia, hiccup, acidity, constipation & vomiting tendency.

CII: Hazmotab tablet should not be given to patient with peptic & duodenal ulceration and empty stomach.

SIE: No significant side·effects. Dosage: Adult: 1·2 tablets 2·3 times daily chewable or with water before/after meal. Children: 1/2·1 tablet daily chewable or with

RAUWOLFIA PREPN38 .:. NORMATENSIN Tab. Hamdard38 Normatensin is an effective herbal medicine to normalize hypertension and anxiety. The main ingredient of normatensin is Rauwolfia serpentina contains reserpine & rescinnamine are ideal tranquilizer and anti·psychotic. It is very

liver, enlarged liver, heptalgia, liver cirrhosis.

water before/after meal.

effective in insomnia, hysteria, epilepsy, violent


1 00's pack: 50.00 MRP

mania, schizophrenia, severe persistent headache,

QIMP-1S (441)

catecholamine (epinephrine and nor-epinephrine),

& antitussive preparation.

which release from the sympathetic nerve

Alvasin is a unique combination of valuable

of hot water and to be taken 2-3 times daily or as directed by the physician. If sweetened with 2 or 3 crushed sualin tablets, it enhances its effects.

endings due to its sympatholytic effects.

herbs for all types of cough & cold. It is an

25 sachets pack: 1 65.00

Comp: Each tablet contains:

excellent bronchodilator with anti-allergic

tension and irritative conditions of the CNS.

.:. ALVASIN Syp. Hamdard38

Normatensin prevents the action of

Alvasin syrup is an effective herbal expectorant

Rauwolfia

serpentina root (Sarpagandha) 1 5 1.52mg,

properties for both adults and children. It is well

Potassium bromide B.P 75.76mg, Magnesium

tolerated, safe and non-sedative in action. Dry cough, bronchitis, whooping cough,

carbonate B.P l S.94mg, Silicate of alumina with

Ind:

magnesia 3.7 Smg.

hoarseness of voice, common cold, congestion of

Ind: Hypertension, insomnia, anxiety, tension,

lungs, hacking cough, bronchial asthma, allergic

persistent headache, epilepsy, hysteria, insanity.

cough, influenza, smokers cough, tonsillitis,

CII: Normatensin is contraindicated in

tubercular cough and sore throat.

depression, ulcerations, pregnancy & lactation.

CII: There is no known contraindcation. SIE: No significant side-effect has been observed. Dosage: Aduils: 2-5 tsf (lO-2Sml) twice daily or as directed by the physician. Children under 12 years: 1-2 tsf (S-lOml) twice daily or as directed by the physician.

SIE: There are no known side effects in proper dosages. Side effects may occur occasionally nasal congestion, drowsiness, vomiting.

Dosage: 1-2 tablets twice daily or as directed by the physician.


20 tabs pack: 2S.00 MRP

225m1 bot: 7S.00 MRP

INDIGENOUS COUGH

,_

PREPARATIONS .:. ACME'S BASOK Syp. Acme38 Acme's basok syrup is a combination of herbs that is used to treat cough and some other

t r

respiratory tract disorders. All of the herbs in this combination are clinically effective in case of

I .,. .

,

•

",

cough and cold. It is well tolerated, safe and nonsedating with expectorant and antihistaminic properties. It is available as syrup in lOOml bottle.

Comp:

Each 5m1 contains: Adhatoda vasica,

cordia latifolia, Glycyrrhiza glabra, Althaea

Ind:

:. COFLEX Syp. A.H Janakalyan38,64

•

It is prepared from the extracts of known

longum, Piper nigrum, Zingiber officinale)

Ind:

20.34mg, Syzygium aromaticum 6.7Smg,

asthma, tubercular cough, whooping cough, flu

Trizatak (Cinnamomum zeylanicum, Cinnamo

and post-influenzal cough.

mum tamala, Elettaria cardamomum) 20.34mg,

Ind: Basok syrup relieves allergic and dry

Dosage: Adult- 2 tsf thrice daily; in severe cases 2 tsf 6 hourly. Chidren- 114 to 1/2 tsf as per direction of the physicians.

irritable cough. It liquefies phlegm. It is very

lOOml bot: 40.00

The safety of basok syrup in

pregnancy has not been established. Therefore, it should be used with caution during pregnancy considering benefits to the mother greater than the risks to the fetus.

Dosage & admin: Children under 12 years: 12 tsf (S-10ml) 3 times a day. Adults: 3 tsf (lSml) 2-3 times a day. In acute cough, warm water can be added for better result. Or, as directed by the physician.

CII: No contraindication are reported in recommended dosages.

Dosage: Adults- 2 to 3 tsf 2 to 3 times daily; Children- 1 to 2 tsf 2 to 3 times daily. To be used 7 days. lOOml bot: 30.00 MRP 200ml bot: 52.00 MRP

.:. SADURI Syp. Hamdard38

It is made from the extracts of known

herbal decongestive ingredients, like adhatoda

asthma, tubercular cough, whooping cough, flu

vasica, Cordia dichotama, Malva sylvestris,

Use in pregnancy:

due to cold.

Ind:

Centella asiatica etc.

recommended doses, side effects are rare.

Tenaceous cough, chronic cough, day


6.7Smg, Acorus calamus 6.7Smg, Trikatu ( Piper

In the

Ind:

cough, irritative cough, cold, cold-fever, headace

Dosage: 3 tsf 2-3 times daily.

Glycyrhiza glabra 6.7Smg, Ficas infectoria

SIE: It is safe & well tolerated.

globra, Rosa damascena, Zizyphus sativa.

vasica, ocimum sanctum, zizyphus vulgaris and

C/I: No contraindication has been reported.

Comp:

may happen is patients who are hypersensitive to

Cordia dichotama, Plantago ovata, Onosma bracteatum, Althaea officinalis, Glycerrhiza

smoking, allergic cough, hoarseness of voice.

herbal decongestive ingredients like Adbatoda

any of its ingredients.

herbal plants- Centella asiatica, Adhatoda vasica,

Comp:

Dry cough, chronic cough, cough due to

73.24mg, Woodfordia fruticosa 1 . 14gm,

CII: There is no specific contraindication, but it

The important ingredients of this

with bronchodilatation.

ingredients.

with bronchodilatation.

hoarseness. It also gives relief from common cold

Comp:

preparation are the extracts of the following

Centella asiatica, Cydonia oblonga and other

Vitis vinifera 0. 1 4gm, Terminalia chebula

and bronchitis.

It is an expectorant cough preparation of herbal origin.

A non sedative expectorant and decongestant

Adbatoda vasica 0.6Sgm, Piper longuln 0.14gm,

effective in asthma, smoker's cough and throat

MRP

.:. PECTORAL Syp. Jayson Natural55

officinale, Malva sylvestris, Nymphaea lotus,

A non-sedative expectorant and decongestant

Tulsi extract has been added to this syrup.

I

:. ANTICO Syp. Deep-Laidl42

•

Antico is a herbal cough expectorant syrup.

Comp: Each 5m1 syrup contains- extracts of

Rhus succedanea 6.7Smg, Myrica nagi 6.7Smg.

I,


Chronic and acute bronchitis, cold, catarrh,

MRP

.:. JOSHINA Sachet Hamdard38 10shina contains glycyrrhiza glabra (Jashtimodhu), Cordia dichotama (Sapistan), Malva sylvestris (Khobbazi), Althaea officinalis (Khatmi), Viola odorata (Gulebanafsha), Borago officinalis (Gaozaban) and Zizyphus vulgaris (Unnab) which have been recognized as the most efficacious herbal cure for cold, bronchitis and

sisymbrium irio. Chronic and acute bronchitis, cold, catarrh,

and post-influenzal cough .

Dosage: Adult, 2 tsf at morning and evening; in severe cases take one dose more at bedtime. If severity persists, 1 tsf can be repeated every four hours, but total intake must not exceed 6 tsf in a day. Children, 1/4 to 1/2 tsf as per directions. 100ml bot: 30.00 MRP

.:. SUALIN Tab. Hamdard38 A preparation for cough, cold and bronchitis.

Comp:

It is made from chosen ingredients and

herbs for cough, cold and bronchitis, like glycyrrhiza glabra, adhatoda vasica, ocimum sanctum, zizyphus, cinnamon and anisi.

Ind:

It is a proven remedy for influenza,

bronchitis tonsillitis, sore throat, cold and cough, congestion of sinuses and lungs; hoarseness of voice.

Dosage: 2 tablets be chewed three times a day or more as directed by the physician. It is very effective when taken dissolved in boiled water. It may be taken along with Joshanda. lOO's pack: 120.00 MRP

inflarmnatory diseases of the respiratory tract.

Comp:

Each sachet contains: Glycyrrhiza glabra

1 .34gm, Cordia dichotoma 1 . 34gm, Malva sylvestris 0.71gm, Althaea officinalis 0.54gm, Viola odorata 0.45gm, Borago officinalis 0.36gm, Zizyphus vulgaris 0.27 gm.

NEUROTONIC

PREPARATIONS & ANTIDEPRESSANTS

Ind: Cold & cough, bronchitis, tonsillitis, catarrh, catarrhal fever, catarrhal pain, headache & sorethroat.

.:. ARECONA Syp. Jayson Natural55 Arecona is a nootropic & neurotonic herbal

Drug inter: No clinically significant drug

CII: There is no known contraindication. SIE: No Significant side effect has been observed

interactions have been reported.

in proper dosage.


Dosage: I sachet joshina be dissolved in a cup

Comp: Each 5m1 contains Areca catechu 2gm. Ind: Post stroke complications, cerebral

preparation.

QIMP-15 (442)


insufficiency, unconsciousness, paralysis, urinary retention due to cerebrovascular diseases and nervousness. CII: Arecona is contra-indicated in patients suffering from obstructive airway diseases, asthma, chronic diarrhoea, pregnancy epilepsy, gangrene, myocardial infarction, glaucoma, S/E: Large doses may cause diarrhoea, bronchospasm, precipitation of asthma and palpitation. Dosage: Adult· 1 tsf 4 times daily. Children- as

300mg.

following mode of administration: daily 2+0+2

Ind: Depressive moods, anxiety & nervous unrest.

capsules for 5 days, then daily 2+0+1 capsules

hypersensitivity to hypericum perforatum standardized extract. S/E: Photosensitization is possible, specially in fair-skinned individuals. Pregnancy & lactation: It is contraindicated during pregnancy but not contraindicated during lactation.

maintenance dose.

C/I: History of photosensitivity or a

Dosage & admin: 1 capsule 3 times daily, or as

directed by the physician.

directed by the physician.


Drug inter: It interacts with selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants, amphetamine, monoamine oxidase inhibitors (MAOIs), dopamine agonist such as bromocriptine, warfarin etc. 20's pack: 60.00 MRP

.:. GINGO Tab. Acme46

Ginkgo leaf is commonly used in the treatment of early-stage Alzheimer's disease, vascular dementia, peripheral claudication, and tinnitus of vascular origin. Multiple trials investigating the efficacy of ginkgo biloba for treating cerebrovascular disease and dementia have been performed. Comp: Each tablet contains ginkgo leaf 40mg (standardized extract). Ind: Symptomatic relief of organic brain dysfunction (memory deficits, disturbances in concentration), Intermittent claudication, vertigo, tinnitus. CII: Ginkgo leaf may lower seizure threshold. It should not be used in any patient known to be allergic to it or any of its constituents. S/E: Very seldom cases of stomach or intestinal upset, headache, or allergic skin reaction. Precautions: Consider discontinuing ginkgo leaf prior to elective surgery as it may increase the risk of postoperative bleeding. Pregnancy & lactation: No restrictions known. Dosage & admin: Symptomatic relief of organic brain dysfunctions: 3-6 tablets daily in 2-3 divided doses. Length of treatment should be judged according to the severity of symptoms and should extend at least 8 weeks in the case of chronic illness. Continuation of

.:. SEJIN Syp_ Deep.Laid 1 42

Sejin is a nerve stimulant and energy enhancer herbal syrup. Comp: Each 5ml contains: Cinnamomum cassia, Embelica officinale, Smilax china, Psidium guyava, Hyosyamus niger, Syzygium aromaticurn, Myristica fragrans, Centauria behen, Salvia haematodes, Curcoligo orchioides, Withania somnifera and other ingredients. Ind: Nervous weakness, General weakness, Exhaustion. CII: No contraindication has been reported. Dosage: 3 tsf (15ml) twice or thrice daily. l OOml bot: 40.00 MRP 450ml bot: 160.00 MRP

PREPARATIONS WITH HORMONE-LIKE

ACTIVITY & SEX STIMULANT

treatment for more than 3 months should be reviewed for its justification. Intermittent claudications, vertigo & tinnitus: 2·4 tablets

.:. APHRODIN Cap. Jayson Natural55

daily in 2·3 divided doses. Improvement of

Aphrodin is a potent aphrodisiac prepatation, safe remedy for sexual and psychogenic impotence in male. Active herbal constituents of aphrodin demonstrate hormone-like activity and maintain hormonal equilibrium. Aphrodin is equally effective, safe & reliable in female frigidity & lack of orgasm, physical exhaustion and nervous debility. Comp: Each capsule contains ingredients of A1pinia galanga, Myristica fragrans, Sizygium aromaticum, Crocus sativus, Strychnos nux· vomica, Treated cantharides, Testicular extract, Musk xylol, Ambra grasea, Argentum oxidacum, Treated asphaltum, Hen's egg yolk. Ind: Sexual weakness, premature ejaculation, nervous debility, general weakness. CII: Aphrodin is contraindicated in advanced arteriosclerosis and chronic renal diseases. Precaution: Use with caution in hypertension.

ambulatory range requires administration for not less than 6 weeks. In case of vertigo & tinnitus, administration for more than 6·8 weeks has no therapeutic benefit. Drug inter: Anticoagulants, antiplatelet agents, low molecular weight heparin and thrombolytic agents may increase the risk of bleeding complications. Anticonvulsants may precipitate seizures in epileptic patients. 50's pack: 250.00 MRP .:. PERKUP Cap. Acme46

Hypericum perforatum (St. John's Wort) standardized extract has been used mediCinally for over 200 years. The main active principles of the herb are the flavone & flavonol derivatives, xanthones and naphthodianthrone (hypericins). It has antidepressant and anxiolytic action. Nurnerous studies reported that hypericum perforatum standardized extract is more effective than placebo and equally effective as tricyclic antidepressant drugs in the short-term treatment of mild to moderate major depression. Comp: Each capsule contains hypericurn perforatum (St. John's Wort) standardized extract

Dosage & admin: Usually one capsule in the morning and one capsule at bed time or two capsules before bed time, preferably be taken with milk, or honey daily. Aphrodin should be continued at least 3·4 weeks for optimum result. For better result, patients are advised

for 10 days, followed by 1+0+1 capsule as Continuous use of aphrodin may serve as a good general restorative tonic. For complete

functional impotence it is necessary to increase the above dosage of aphrodin to 2 capsules !.i.d. This should be given nnder constant supervision.

lO's pack: 300.00 MRP .:. CASTORIN Cap. A.H Janakalyan38•64

A tonic for youthful vigour. Comp: A preparation of Saffron, Lacerta agilis, Calcined tin and other herbs etc. Ind: It is a tonic which increases libido, helps retentive power and maintains youthful vigour. Dosage: 2 capsules to be taken with

milk two

hours before coitus. Dinner should be taken 2· 3 hours earlier and very light too.

2's pack: 100.00 MRP 12's pack: 600.00 MRP .:. DUREX Cap. A.H. Janakalyan38•64

Durex is a herbal stimulant & aphrodisiac prepn. Comp: Each 250mg capsule contains: Strychnos nux· vomica 1 20mg, piper nigrum 6Omg, piper longum 60mg, ambra grasea 1 0mg, & piper betle. Ind: Durex is a aphrodisiac preparation, which enhances viscosity of semen, increases retentive power, strengthens nervous system & prevents premature ejaCUlation. Dosage: 2 capsules to be taken 1·2 times daily.

4's pack: 100.00 MRP 30's pack: 750.00 MRP .:. ENDUREX Cap. Hamdard38

Endurex is a herbal aphrodisiac preparation. Comp: Each capsule contains ingredients of Ambra grasea (ambor) 1 1 .90mg; Piper nigrum (gol morich) 59.52mg; Piper longum (peepal) 59.52mg; Piper betle (paan) & other ingredients Q.S. Ind: It is a sexual tonic which increases libido, prevents premature ejaculation & enhances retentive power. It is also an effective preparation in the treatment of Bell's palsy, numbness, pain & rheumatism. C/I: There is no known contraindication. S/E: No significant side effect has been observed. Dosage: 2 capsules 1·2 times daily.

20's pack: 760.00 MRP .:. FRODEX Tab. Hamdard38

A masculine tonic for the vital organs. Comp: This formula contains Ambergis, Momyaie. Agar, Salvia haematodes, Myristica fragrans and Mineral Bezoar (Zehar Mohra), Cinnamomum, Bambusa arundinacea, Silver foil, Paeonia emodi and other ingredients. Ind: It restores the depleted sexual power. It relieves limpness and weakness after coitus. It also enhances retentive power. Its continuous use serves as a good general tonic. Dosage: 1 tablet to be taken with milk in the morning & 1 at bedtime.

20's pack: 460.00 MRP .:. LmIDEX Cap. Hamdard38

Libidex is a natural aphrodisiac preparation. Comp: This formula contains- Myristica fragrans

QIMP-15 (443)


(arillus), Lacerta agilis, Argyreia speciosa,

acts or other causes nerves, blood vessels and

Myristica fragrans (fruit), Calcined silver, Crocus

tissues lost their elasticity and blood cannot store

semen, increases retentive power, strengthens

sativus,

long time in the blood vessels which reduces the

nervous system, prevents premature ejaculation,

Mineral bezoar, Castorium & other ingredients.

erecting time and makes the male organ weak.

prolongs the duration of coitus & ensures post

Ind: It is a natural aphrodisiac preparation, whlch

Tila Jadeed strengthens the tissue, stimulates the

coitus freshness. It is safe & effective sex tonic.

increases libido, prevents premature ejaculation,

nerves and muscles as well as the flow of blood

CII: There is no absolute contraindication.

maintains optimum duration, ensures pleasant

in the male organ, thus providing it stiffness and

SIE: Not yet known.

orgasm & post coitus freshness, enhances retentive

full erection. It also increases the elasticity of

Dosage & admin: 1-2 capsules before bed time.

power.

male organ.

30's pack: 360.00 MRP

CII: There is no known contra-indication.

Comp: Each 5m1 contains: Calotropis gigailtea

SIE: No significant side effect has been observed.

O.2Omg, Myristica fragrans (aril) 0.23mg,

Dosage: 1-2 capsule daily_

Myristica fragrans (nut) 0.23mg, Eugenia

20's pack: 400.00 MRP

caryophyllus 0.23mg, Anacyclus pyrethrum

.:. LEBONEX Tab. Deep-Laidl42 Libonex is a safe & powerful sex stimulant. Comp: Each tablet contains: Myristica fragrans, Lecerta agilis, Argyreia speciosa, Myristica fragrans Fruit, Calcined silver, Crocus sativus, Mineral bezoar, Castorium, Piper betle.

Ind: Sexual impotency, Loss of retentive power, Premature ejaculation, Nervous weakness, Frigidity, Spermatorrhoea.

CII: Hyper tension. Dosage: 1 tab. at morning & 1 tab. at night after meal with milk or water. 20's pack: 250.00 MRP

.:. NISHAT Tab. Hamdard38 A tonic for youthful vigour. Comp: A preparation of Saffron, Lacerta agilis, Calcined tin and other herbs etc.

Ind: It is a tonic which increases libido, helps retentive power and maintains youthful vigour.

Dosage: 2 tablets to be taken with milk two hours before coitus. Dinner should be taken 2-

3 hours earlier and very light too.

0.23mg, Crocus sativus 0.07mg, Cochineal insect 0.23mg, Castoreum 0.07mg.

Ind: Sluggishness, feebleness, curvature, Dosage: Rub gently 5-6 drops of Tila Jadeed all around on the penis once a day. For full recovery use it for 3-4 weeks or as directed by the physician.

tissues los! their elasticity and blood cannot store long time in the blood vessels whlch reduces the erecting time and makes the male organ weak. Tila-e-Jadeed strengthens the tissue, stimulates the nerves and muscles as well as the flow of blood in the male organ, thus providing it stiffness and full erection. It also increases the elasticity of male organ.

Comp: Each 5m1 contains: Calotropis gigantea 0.2Omg, Myristica fragrans (aril) 0.23mg, Myristica fragrans (nut) 0.23mg, Eugenia caryophyllus 0.23mg, Anacyclus pyrethrum 0.23mg, Crocus sativus O.07mg, Cochineal insect 0.23mg, Castoreum 0.07mg.

Ind: Sluggishness, feebleness, curvature, shortness and obliquity of male organ.

Dosage: Rub gently 5-6 drops of Tila-e-Jadeed all around on the penis once a day. For full recovery use it for 3-4 weeks or as directed by the physician. CII: There is no known contraindication. SIE: No significant side effect has been observed in proper dosage.

15m1 bot: 150.00 MRP

:. TILA JADEED Rub Hamdard38

Syzygium aromaticum, Myristica fragrans,

Ind: Vimex is indicated for adult male in sexual debility, impotency & general weakness. It enhances the secretion of hormone through natural way & increases desire. It develops penile erection, provides energy in brain to keep it active.

CII: There is no known contraindication. SIE: No significant side effect has been observed in proper dosage.

CII: It should not be prescribed to chlld & adolescent. Without doctor concern hypertensive patient should not take vimex.

15ml bot: 1 10.00 MRP

SIE: Some patients may report of vertigo, nausea & anorexia.

:. TRIGONE Tab. Hamdard38

•

Dosage: For rapid sexual performance: 2

Trigone is a natural aphrodisiac with the judicious combination of synergistically acting precious natural ingredients like amber, castorium, mmi mostogi etc. It is available as tablets in plastic container.

tablet once after an hour of meal. For general weakness: 1 tab_ at morning & 1 tab. at night. 20's pack: 350.00 MRP

.:. VITOLEX Cap. A.H Janakalyan38•64

Comp: Each tablet contains: Seriparium 57.69mg, Ambra grasea 38.46mg, Orchls latifolia 38.46mg, Alpinia galanga 38.46mg, Castorium 38.46mg, Pistacia lentiscus 1 9.23mg, Eugenia

Ind: Sexual debility, nervous debility, mental

male organ. For excessive indulgence in sexual

Asphaltum, Mytilus margaritiferus, Pistacia vera,

Castorium, and other active ingredients.

shortness and obliquity of male organ.

:. TILA-E-JADEED Rub A.H Janakalyan38 Tila-e-Jadeed is hlghly effective in sluggishness,

acts or other causes nerves, blood vessels and

Comp: Each tablet contains:- Ambra grasea,

Pastinaca secacul, Delphinium denudatum ,

caryophyllus 19.23mg.

feebleness, curvature, shortness and obliquity of

.:. VIMEX Tab. Deep-Laidl42 Vimex is a herbal aphrodisiac & anti-oxidant prepn.

100's pack: 700.00 MRP •

production of the sperm, enhances viscosity of

Vitolex is a natural aphrodisiac capsule.

Comp: Thls formula contains- Myristica fragrans (arillus), Lacerta agilis, Argyreia speciosa, Myristica fragrans (fruit), Calcined silver, Crocus sativus,

(Ref: Habb-e ambari) weakness & weakness of heart, brain, liver and kidney, poor immune function, biochemical imbalance, physiological dysfunction.


Mineral bezoar, Castorium & other ingredients .

Ind: It is a natural aphrodisiac preparation, whlch increases libido, prevents premature ejaculation, maintains optimum duration, ensures pleasant orgasm & post coitus freshness, enhances


in proper dosage.

Dosage & admin: I tablet in the morning and

1 tablet in the evening or 2 tablets be taken before going to bed or as directed by the

retentive power. It maintains youthful vigour and relieves physical & mental exhaustion.

CII: There is no known contraindication. SIE: No significant side effect has been observed.

Dosage: 1-2 capsule daily.

physician. Dinner should be taken 2-3 hours


earlier and very light too for optimum

IO's pack: 500.00 MRP

bioavailability and desired result. Trigone tablet may be used along with a glass of or 15ml honey. If milk or honey is not

milk

ANALGESIC,

available, Trigone tablet may be used with

ANTIPYRETIC &

30ml cinkara syrup or 20ml jinsant syrup or a glass of water. 10 tabs pack: 500.00 MRP

DIURETIC PREPNS.

.:. VIGO-FORT Cap. Acme46 Jouban satadal 25Omglcapsule. Vigo-fort is a herbal aphrodisiac capsule.

Comp: Each vigo-fort capsule contains following main herbal ingredients: Withania somnifera 14.29mg, muCuna pmrita 14.29mg, anacyclus pyrethrum 14.29mg, myristica

.:. ALKULI (Buzuri) Syp. Hamdard38 Antipyretic & Diuretic

Comp: A herbal preparation of cichorium endivia, cucumis melo, foeniculum valgare, tribulus terestris.

fragrans 14.29mg, swama sindur 14.29mg, aurum

Ind: Pyrexia, anuria, oliguria, hepatitis, obstructive

7.14mg, pearl 7 . 1 4mg, stannum 7 . 1 4mg, crocus

jaundice. It is also very effective to clear the morbid

sativus 14.29mg, syzygium aromaticum 14.29mg,

substances from the kidney & urinary bladder.

zingiber officinale 14.29mg, piper longum

Use: Adults, 2 to 4 tsf twice to four times daily.

feebleness, curvature, shortness and obliquity of

14.29mg, pterocarpus santalinus 14.29mg.

Childrens, 1 to 2 tsf as per direction.

male organ. For excessive indulgence in sexual

Ind: Increases the secretion of testosterone &


•

Tila Jadeed is highly effective in sluggishness,


450m! bot: 82.00 MRP

:. FEBRINE Tab. Deep_Laid 142 Febrine is a herbal antipyretic & analgesic. It is effective in fever and pain. It also increases immunity power. Camp: Each tablet contains: Ocimum album, Caesalpinia bonducella, Tinospora cordifolia, Piper nigrum. Ind: Fever, pain, all febrile condition, lllcterial fever, viral fever, tooth ache, headache. Dosage: Child (3-7 yrs): 1 tablet 2-3 times daily. Adult: 1-2 tablets, 2-3 times daily. 50's pack: 75.00 MRP •

.:. FEVNlL Syp. Hamdard38 Fevnil is a unique combination of valuable natural ingredients. The main ingredient of fevnil "Bonsarisha" contains sinigrin which is antipyretic, antibacterial (specially effective against salmonella typhi, salmonella paratyphi) and antiviral. Fevnil is very effective in typhoid. paratyphoid, measles & chicken pox. Fevnil is immunostimulant, demulcent, alterative, analgesic & hepatoprotective. It is available as syrup in 100mi glass bottle. Camp: Each 5m! syrup con4\ins (as aq. extract), Sisymbrium irio (Bon sarisIW'khak:si) 0.25gm, Zizyphus jujuba (BorialUnnab) 0.25gm, Foeniculum vulgare (Mouri) 0.25mg, Borago officinalis (Gaozaban) 0. 15gm. (Ref: Sharbat khaksi). Iud: Fever, influenza, typhoid, paratyphoid, measles, c;hickenpox. CII: There is no known contraindication. S!E: No significant side effect has been observed in proper dosage. Dosage: Adults: 2-4 tsf 2-3 times daily. Children: 112-1 tsf 2-3 times daily or as directed by the physician. 100m! bot: 36.00 MRP .:. RENATON (Buzuri) SYIl. A.H Janakalyan38 .64 Renaton is a herbal antipyretic & diuretic prepn. Camp: A combined preparation of cichorium endivia, cucumis melo, foeniculum valgare, tribulus terestris. Ind: Pyrexia, anuria, oliguria, hepatitis, obstructive jaundice. It is also very effective to clear the morbid substances from the kidney & urinary bladder. Use: Adults, 2 to 4 tsf twice to four times daily. Childrens, 1 to 2 tsf as per direction. 100m! bot: 25.00 MRP 250m! bot: 50.00 MRP 450ml bot: 90.00 MRP

DRUGS FOR RHEUMATIC DISORDERS •:. REUMAC Cap. Jayson Natural55 Reumac capsule is a herbal preparation for rheumatic and inflammatory disorders.

Comp: Each capsule contains ingredients of the following herbal components: Operculina turpethum, Calchicum luteum, Aloe barbadensis, Pimpinalla anisum, Indigofera tinctonia, Balsam odendron mukul, Pistacia lentiseus.

QIMP-15 (444)

Ind: Rheumatism, rheumatoid arthritis, gout, lumbago, inflammatory & painful conditions . S!E: Over dosage may cause abdominal discomfort. Precaution: Reumac capsule should be used with caution in case of severe peptic & duodenal ulceration. Pregnancy & lactation: The drug should not be used in the first and last trimesters of pregnancy unless absolutely needed. Safe for use in lactation. Dosage & admin: Adult- 2 to 4 capsules 2 times daily after meal. Children over 6 years1 to 2 capsules 2 times daily after meal. 50's pack: 90.00 MRP .:. RHEMEX Cap. Deep_Laid 142 Rhemex is a natural remedy for rheumatism & gout pain and does not cause any hyperacidity. Camp: Each capsule contains: Operculina Turpethum, Colchicum Luteum, Aloe Barbadensis, Pimpinella Anisum, Indigofera Tinctoria, Balsam Odendron Mukul, Pistacia Lentiscus. Ind: Rheumatoid arthritis, gout, Lumbago, joint inflammation and body ache. CII: Pregnant mother and child below 6 years. S!E: Over dose may cause abdominal discomfort. Dosage: 1-2 capsule twice daily after meal. To get better result, patient should take rhemex for 2-3 weaks. 50's pack: 200.00 MRP .:. RHEUFEN Oint. Deep-Laid Rheufen is a herbal formula for rheumatism. Camp: Each 5gm contains: Rubia Cordifolia, Cinnamomum Cassia, Myrica Sapida, Usnea Longisima, Cyperous Rotundus, Acorus Calamus, Syzygium Aromaticum, Curcuma Zedoria, Cesumum Indicum, Brasica Camprestris. Ind: External use for rheumatism, pain, swelling, muscle and joint pain, gout pain. Dosage: Locally apply the liniment to affected site. 20gm tube: 55.00 MRP .:. RHEUMACON Tab. A.H Janakalyan38•64 Camp: It is a herbal preparation of the extract of aloe barbadensis, colchicum luteum, terminalia chebula. Each herb has an specific action. Ind: This combined preparation is highly effective in all kinds of rheumatism, such as chronic rheumatoid arthritis, osteoarthritis, sciatica lumbago, gout etc. S!E: It does not cause any irritation or pain in the gastrointestinal tract. Use: One to two tablets twice a day after meal. 12's pack: 48.00 MRP 50's pack: 200.00 MRP .:. SURANJAN Tab. Hamdard38 Camp: It is a unique herbal preparation of the extract of aloe barbadensis, colchicum luteum, terminalia chebula. Each herb has an specific action. Ind: This combined preparation is highly effective in all kinds of rheumatism, such as chronic "rheumatoid arthritis, osteoarthritis, sciatica lumbago, gout etc. S!E: It does not cause any irritation or pain in the gastrointestinal tract. Use: One to two tablets twice a day after meal. l 00's pack: 220.00 MRP

PREPARATIONS FOR SOFT-TISSUE

INFLAMMATION & PAIN .:. HAMDARD BALM Oint. Hamdard38 A preparation of menthol, thymol, eucalyptus oil & camphor, useful as counter-irritant & rubefacient. Ind: It is a quick-acting penetrating balm for extermal use for coughs, colds, bronchitis, sore throat, nasal and chest congestion, muscular pains, sprains and insects bite etc. Use: It should be rubbed well on the chest, forehead, throat, and on the affected and painful parts of the body. 7gm pack: 10.00 MRP .:. JANA:KALYAN BALM Oint. A.H Janakalyan38 A preparation of menthol, thymol, eucalyptus oil & camphor, useful as counter-irritant & rubefacient. Ind: It is a quick-acting penetrating balm for extermal use for coughs, colds, bronchitis, sore throat, nasal and chest congestion, muscular pains, sprains and insects bite etc. Use: It should be rubbed well on the chest, forehead, throat, and on the affected and painful parts of the body. 8gm pack: 15.00 MRP .:. KULZAM Soln. A.H Janakalyan38 A preparation of thymol, camphor, eucalyptus oil and other herbal ingredients which have useful properties to give relief from pain. Ind: An effective first aid in all wounds and ulcers, cuts and bruises, sores and swellings. If taken internally, it gives ready relief in cholera, diarrhoea, dysentery, chronic pain and stomach upsets is a soothing application in insect bites, burns and scalds. Use: To be applied wherever it is required. 15m! pack: 60.00 MRP .:. KULZAM Soln. Hamdard38 A preparation of thymol, camphor, eucalyptus oil and other herbal ingredients which have useful properties to give relief from pain. Ind: An effective first aid in all wounds and ulcers, cuts and bruises, sores and swellings. If taken internally, it gives ready relief in cholera, diarrhoea, dysentery, chronic pain and stomach upsets is a soothing application in insect bites, burns and scalds. Use: To be applied wherever it is required. 15m! pack: 37.00 MRP .:. MEDIX Herbal Balm Jayson Natural" Each 5gm contains- camphor 769mg, menthol 385mg, thymol 385mg, oil turpentine 385mg. Ind: Inflammation, pain,. bruise'. cuts, abrasion, insect bites, fish stringing, neuralgic pain, headache. Caution: Should not apply in irritable area. Use & admin: Apply to the affected part 3-4 times a day. 10gm tube: 15.00 MRP .:. RUBA Oint. Deep-Laid142 Ruba is a fast pain reliever ointruent. Comp: Each 5 gm contains: Thymol B.P, Menthol B.P, Camphor B:P

QIMP.15 (445)


Ind: Headache, Sprain, minor cut, minor hum

racemosa, Azadirchta indica, Curcuma longa.

pain, pain due to insect bite.

Ind: Skin diseases, Boil, Pimples, Rashes,

Feroma is an iron prepn. with herbal formulation.

Dosage: Apply slight ointment to the site of pain.

Constipation and Inflammation.

200mg with Kuchila extract and Piper longum.

10gm tube: 20.00

MRP

PREPARATIONS FOR SKIN DISEASES

Blemisles, Acne vulgaris, Dermatitis,

CII: Safex is contraindicated in diarrhoea. SIE: Vomiting, and feeling of biter taste. Precaution: Should be avoid allergic or rich food

during treatment with safex.

Dosage: Adults· 2 to 4 tsf thrice daily. Children1 to 2 tsf 1 or 2 times daily. Safex should be continued at least 4·6 wks. for optimum result. l OOml bot: 30.00 MRP

.:. FUNCI Oint. Deep·Laid l42

Anti scabies and anti fungal ointment.

Comp: Each 5 gm contains: Monoxide of Lead,

Camphor, Zinc oxide BP, Sulphur sublimath BP, Acacia laucophloea 125 mg and other ingradients

Ind: Scabies, fungal infection & topical sepsis. Dosage: Cleaning the afected area, apply the ointment twice or thrice daily. IOgm tube: 30.00 MRP

.:. HEMODISE Syp. Deep·Laid l42

200m! bot: 48.00

450m! bot: 92.00 MRP

eruptions and epistaxis. it also relieves

constipation, general depression, improves

Artemisia bsenthium, Nymphaea lotus, Dalbergia sisso, Pterocarpus santalinus, Tinospora

cordifolia, Terminalia chebula, Curcuma

Zedoaria, Swertia chirata, Andrographis

paniculata, Bauhinia racemosa, Azadirachta

indica, Curcuma longa.

Ind: All types skin diseases, Acne, Pimples,

dermatitis, itching, Abscess, Boil, Carbuncle etc.

CII: Not advised during pregnancy. Dosage: 10 ml 2·3 times daily. 100 ml bottle: 28.00 MRP

450 m! bottle:80.00 MRP

Precaution: Use cautiously in patietns with iron storage or iron absorption diseases,

haemoglobinopathies.

Pregnancy & lactation: Safe Jor use in

pregnancy & lactation.

450m! pack: 100.00 MRP

INDIGENOUS TONICS, VITAMINS &

complexion and helps to stay slim and smart.

450m! bot: 90.00 MRP

Kurroo, Fumaria parvifiora , Clitoria tematea,

anemia) and general wealcness.

diseases. It is a natural blood purifier.

Ind: It prevents and cures boils, pimples, skin

basilicum, Operculina turpethum, Rosa

damascena, Sphaeranthus indicus, Gentiana

Ind: Iron deficiency anemia (hypochromic

100m! pack: 30.00 MRP

.:. SAFI Syp. Hamdard38

Safi is a herbal preparation for many skin

Comp: Each 5 m! contains: Cassia angustifolia,

Rheum emodi, Cassia occidentalis, Ocimum

Comp: Each 5m! contains· Ferrous sulphate

Dosage: Adult: 2·3 tsf 3 times daily after meal. Children: 1·2 tsf 3 times daily after meal. The duration is 3·6 weeks. Shake well before use.

MRP

Dosage: 2 tsf in the evening with plain water or a cup of milk. For children doses vary according to age 1/3 to 112 tsf.

Hemodise is a natural blood purifier syrup.

.:. FEROMA Syp Jayson Natural55

100m! bot: 32.00 MRP

NUTRITIONAL PREPNS. .:. ACME'S SPIRULINA Cap. Acme46

Spirulina is a natural nutritional supplement that

.:. SAFKIN Syp. Acme46

Saribadyarista 200ml syrup

Safkin is a combination of effective herbs that

has hepatoprotective, antiallergic, antifungal,

anthelmintic, antibacterial, anti·inflammatory,

wound healing and antioxidant properties. Safkin

is enriched with proteins, vitamins, minerals,

essential anaino acids and essential fatty acids like gamma linolenic acid. It is called a

wonderful gift of the earth. Spirulina belongs to

genus phylum cyanobacteria. Cyanobacteria are

classified as either blue-green algae or as blue

is effective in skin diseases e.g scabies, itching,

green bacteria. Spirulina is a popular nutritional

complexion, Safkin stimulates the natural process

Comp: Each capsule contains 450mg spirulina

detoxification processes and thus helps in the

Carhohydrates '15-25%; Fats (lipids) 6·8%; Fiber

saribadyarista. It is available as syrup in 200m!

B 12, C, D, E, K, Folic acid, Pantothenic acid,

boil, pimple & dermatitis.

It also improves

of blood purification. It helps the liver in

treatment of skin diseases.

It is also kuown as

supplement in japan and USA.

which consists of· Protein 55·70%;

8-10%; Vitanains: Beta carotene, B I, B2, B3, B6,

bottle.

Inositol & Biotin; Minerals: Calcium,

Purin is a herbal preparation for many skin

herbs in different concentration.

Potassium, Zine, Copper, Manganese, Boron,

Ind: Skin diseases, Boil, Pimples, Rashes, Acne

scabies, itching, boil & pimple, dermatitis;

.:. PURIN Syp. A.H Janakalyan38,64

Comp: Safkin contains extracts of about 69


Ind: Blood purification; skin diseases e.g

vulgaris, Dermatitis. It also relieves constipation,

complexion enhancer.

improves complexion & helps to stay slim & smart.

CII: Purin is contraindicated in diarrhoea. SIE: Vomiting, and feeling of biter taste. Precaution: Should be avoid allergic or rich food

during' treatment with safex.

Dosage: 2 tsf in the evening with plain water or a cup of milk. For children doses vary according to age 1/3 to 112 tsf. 250m! bot: 60.00 MRP

450m! bot: 100.00 MRP

.:. SAFEX Syp. Jayson Natural55

Safex is a herbal preparation for many skin

CII: There is no absolute contraindication. SIE: Not yet known. Dosage & admin: Adult: 2·4 tsf 1·2 times daily after meal. Children under 12 years: 1·2 tsf 1·2 times daily after meal. Or as directed by the physician. 200m! bot: 60.00 MRP

PREPARATIONS

SIE: Spirulina is generally well tolerated.

Occasional gastrointestinal symptoms, such as

nausea have been reported. Also there are few

reports of allergic reactions to spirulina

metals, such as mercury, from contaminated

spirulina supplements should select reputable

products that are free of any heavy metal

contamination.

.:. DEGLOBIN Syp. Deep·Laidl 42

vulgare, Aqua' Rosa damascena, ferrous sulphate

absinthimum, Nymphaea alba, Dalbergia sissoo,

Ind: Anemia due to iron deficiency & others. Dosage: lOml 2·3 times daily.

chirafa, Andrographis paniculata, Bauhinia

CII: Spirulina is contraindicated in those who are

hypersensitive to any component of this product.

waters in which it is cultivated, Those who use

Sphaeranthus indicus, Gentiana kurro, Fumaria

Terminalia chebula, Zingiber zerumbet, Swertia

blindness and to enhance immunity.

HAEMATINIC

Deglobin is a herbal haematinic syrup.

Pterocarpus santalinus, Tinospora cordifolia,

prevention of malnutrition, anemia, night

Precautions: Spirulina can accumulate heavy

emodi, Cassia sophera, Ocimum albam,

parvilora, Clitoria tematea, Artemisia

Ind: Spirulina is indicated for the treatment and

INDIGENOUS

Comp: Safex is composed of different herbal

Operculina turpethum, Rosa damascena,

Chrominum & Selenium and Amino acids.

containing supplements.


ingredients, such as·Cassia angustifolia, Rheum

Phosphorus, Magnesium, Iron, Sodium,

Comp: Each 5 m! contains: Aqua' Foeniculum

and other ingredients

100 m! bottle: 25.00 MRP

450 m! bottle: 65.00 MRP

Pregnancy & lactation: Should be avoided. Dosage & admin: 2 to 6 capsules daily or as directed by the physician. Children: The use & safety of spirulina for children under 18 has not yet been established. Drug inter: There are no reports suggesting that spirulina interacts with any conventional

medication.

30's pack: 1 20.00 MRP


QIMP-15 (446)

.:. ACVIT Syp_ Deep-Laid !42

mental performance; in mild malnutrition & loss

Natural vitamin enriched tonic.

of weight; to increase stamina; to protect liver

grasea and other herbal precious ingredients like

function; in excessive metabolism, vitamin

onosma bracteatum, Crocus sativus & Silver

Vitis vinifera, CarthaJIjUS tinctorius, Elettaria

deficiency due to antibiotics, stress and acute

leaves etc.

cardamomum, Rubia cordifolia, Cassia tamala,

illness. May be given as a dietary supplement to

Ind: It tones up the brain cells and is

Cinnamomum officinalis, Syzygium aromaticum

all in the family.

and other ingredients

Dosage: Adults, 6 tsf twice daily; children, 2 tsf twice daily, or as prescribed by the physician.

successfully prescribed for preserving memory. It

Comp: Each 5 mI contains: Psidium guyava,

Ind: Malnutrition, General weakness, Anorexia, Vitamin B-complex deficiency.

Dosage: Adult: 10-20ml, Child: 5-10ml twice or thrice daily. 100 mI bottle: 30.00 MRP 200 mI bottle: 46.00 MRP 450 mI bottle: 1 00.00 MRP .:. AMLAC Syp. Jayson Natural55 AmIac is a herbal vitamin-C supplement prepn.

Comp: Amlac is composed of different herbal ingredients, such as- Phyllanthus emblica, Piper nigram, Rhus succedanea, Chlorophyfum arundinaceum, Mesua ferrea, Glycerrhiza glabra, Withania somnefera, Cyperus rotundus, Elettaria cardarnomum, Syzygium aromaticum, Cinnarnomum zeylanicum, Osimum album, Potassium carbonate, Adhatoda vasica, Lycium barbarum, Vilax nigunndu, Piper cubeba, Piper longum, Alpinia galanga, Solanum xanthocarpum, Aegle marmelos, Tributus terrestris, Zingiber officinale & other ingredients.

Ind: Vitamin-C deficiency diseases, cough, cold, general weakness, nervous debility, mental fatigue, weakness of memory, indigestion, malnutrition and leanness.

Dosage: Adult: 2-4 tsf 3 times daily. Children: 1-2 tsf 3 times daily. Duration: 15-30 days. Shake well before use; (floating substances are the part of medicine). 100m! bot: 24.00 MRP

.:. CAROTONE Plus Syp. Jayson NaturaJ55 Carotone plus is a preparation of vitamin A & C supplement.

Comp: Carotone plus is composed of extracts of different herbal components, such as- Daucus carota, Phyllanthus emblica, Aquilaria agalloclia, Amomum subulatum, Coriandrum sativum, Cyperus rotundus, Elettaria cardamomum,

Santalum album, Salvia haematodes, Ambar

preserves eyesight and is a very useful tonic for those engaged in mental work.

225m1 bot: 65.00 MRP

Dosage: Adults over 12 years, 1 tsf in empty stomach in the morning or evening. Children between 6-12 years, half tsf_

450m! bot: 95.00 MRP

80gm pack: 290.00 MRP

.:. JANAKALYAN JINSENG Syp. Janakalyan38

A general herbal tonic.

1 00m! bot: 33.00 MRP

.:. MAULLAHAM Syp. Hamdard38

Jinseng syrup is a unique combination of natural

Comp: Maullaham is based on externally

ingredients, which acts as a general tonic,

effective concentrated extracts of fine palatable &

stimulant and aphrodisiac.

nutritious food ingredienis which help the body

Comp: Each 5m1 syrup contains (as aq. extract)

organs, muscles & tissues acquire renewed

Withania somnifera 1 8 .75mg, Nigella sativa

strength.

1 8 .75mg, Allium cepa 37.50mg, Psidium guyava

Ind: The well known tonic of the unani system

75.00mg, Smilax china 75.00mg, Santalum

for heart, brain and nerves. Improves liver and

album 75.00mg, Phyllanthus emblica 75.00mg,

intestinal functions.

37.50mg, Myristica fragrans (Nut) 75.00mg & other

Dosage: 4 tsf to be taken with milk in the morning and evening_

ingredient.

225m1 bot: 55.00 MRP

Salvia haematodes 75.00mg, Zingiber officinale

Ind: General debility, fatigue, sexual debility. Dosage & admin: Adults: 2-4 tsf twice daily. Children: 1-2 tsf twice daily. 250ml bot: 220.00 MRP

.:. JINSANT Syp. Hamdard38 Jinsant syrup is a unique combination of natural ingredients, which acts as a general tonic,

.:. REOVIT Syp. Jayson Natural55 Each 5m1 contains- sida cordifolia 2gm, withania somnifera 2gm, !ilium polyphyllum 42mg, vanda roxburgii 2 1 mg, elettaria cardamomum 2 l mg, ricinus communis 2 l mg, paederia foetida 2 l mg, syzygium aromaticum 2 l mg, vetiveria zizanioides 2 l mg, tribulus terrestris 2 1 mg.

stimulant and aphrodisiac.

Ind: General weakness, malnutrition, nervous

Comp: Each 5m1 syrup contains (as aq. extract)

debility and rheumatism.

Withania somnifera 1 8.75mg, Nigella sativa

Precaution: Use with caution in diabetic

1 8.75mg, Allium cepa 37.50mg, Psidium guyava

patients.

75.00mg, Smilax china 75.00mg, Santalum album 75.00mg, Phyllanthus emblica 75.00mg,

Dosage: Adult: 2-3 tsf thrice daily. Children: 1-2 tsf thrice daily.

Salvia haematodes 75.0Omg, Zingiber officinale


37.50mg, Myristica fragrans (Nut) 75.00mg and


other ingredients q.s.


Ind: General debility, fatigue, sexual debility. Dosage: Adults: 2-4 tsf (10-20ml) twice daily_ Children: 1-2 tsf (5-10ml) twice daily.

ROOH AFZA Syp_ Hamdard38

l OOml bot: 55.00 MRP 225ml bot: 1 1 0.00 MRP

Syrup Rooh afza is a cold drink. It is a blend of pure crystalline invert sugar, distillate flowers, distilled extract of fruits, vegetables and cooling herbal ingredients. Rooh afza's cooling effect is

Syzygium aromaticum, Valeriana jatamansi,

450ml bot: 1 90.00 MRP

Cucuma zedoaria, Cinnamomum zylanicum,

.:. KHAMIRA GAOZABAN AMBER! A.H

Rosa damascena, Santalum album, Ocimum

Janakalyan38

provides extra energy for vital organs like brain,

A semi-solid brain tonic preparation.

heart and liver. Rooh afza protects heat

album, Usnea longissima.

long lasting for not only instantly quenches the thirst but also replaces the loss of body fluids and

Ind: Nervous debility, general weakness, mental

Comp: Its principal ingredients are Bombyx

exhaustion, sun stroke & dehydration. It

fatigue, anaemia, loss of appetite and in vitamin

mori, Lavandula stoechas, Nepeta hindostana,

maintains nutritional status and electrolyte

A & C deficiencies.

Santalum album, Salvia haematodes, Ambar

balance of the body. It is effective in nausea, loss

Dosage: Adult: 2-3 tsf 2-3 times daily. Child: 1-2 tsf 2-3 times daily after meal. Duration: 2-3 weeks or as directed by the doctor.

grasea and other herbal precious ingredients like

of appetite, indigestion, insomnia & fever due to

onosma bracteatum, Crocus sativus & Silver

heat exposure. It keeps the body fresh &

l OOml bot: 30.00 MRP 200ml bot: 50.00 MRP 450ml bot: 95.00 MRP

leaves etc.

energetic when the heat begins to get one down.

Ind: It tones up the brain cells and is

Rooh afza increases the blood calcium and iron

successfully prescribed for preserving memory. It

level. It strengthens bones and muscles.

preserves eyesight and is a very useful tonic for

Pure natural vitaminised rooh afza is also a better

those engaged in mental work.

healthier refresher than other alcoholic or carbonated drinks .

proven bioavailability in mental performance,

Dosage: Adults over 12 years, 1 tsf in empty stomach in the morning or evening. Children between 6-12 years, half tsf.

Comp: Each 50ml contains: Distillate of

anaemia of pregnancy, lactating mothers, liver

l OOgm pack: 300.00 MRP

citrus medica (Lebu) 0.40ml, distillate of rosa

:. CINKARA Syp. Hamdard38

•

A non alcoholic vitaminised herbal tonic of

Ind: General debility, fatigue and during

•:. KHAMIRA GAOZABAN AMBER! IIamdard38

protection etc.

pandanus tectorius (Keora) 1 .75m1, distillate of damascena (Golap) 0.30ml. Distilled extract of- Coriandrum sativum

convalescence; in vitamin deficiencies & lack of

A semi-solid brain tonic preparation.

(Dhania) 2.25m1, Daucus carota (Gajor) 2.25m1,

appetite; in anaemia of pregnancy & lactating

Comp: Its principal ingredients are Bombyx

Portulaca oleracea (Nune shak) 2.25m1, Citrullus

mothers; to improve resistance to infections &

mori, Lavandula stoechas, Nepeta hindostana,

vulgaris (Water melon) 2.25m1, Spinacea oleracea

QIMP·15 (447)

(Palong shak) 2.25m!, Mentha arvensis (Pndina)


80m! bot: 65.00 MRP

DIABETES & URINARY

2.25m!, Luffa cylindrica (Dhundul/Hara ghia) 2.25m!, Cichorium intybus (Kasni) 2.25m!, Vitis vinifera (Grape) 2.25m!, Vetiveria zizanioides

PROBLEMS

INDIGENOUS

(Khas khas) 2.25ml, Nymphaea nauchali (Shapla)

IMMUNOACTIVATOR

2.25m!, Borago officinalis (Gaozaban) 2.25m!,

.:. DOLABI Tab. Hamdard38

Santalum album (Sada chandan) 2.25m!, Parmelia perlata (Charila) 2.25m!, Orange juice 0 . 1 0m!, Pineapple Juice 0.35m!, Invert sugar q.s.

Ind: Dehydration, heat exhaustion, heat stroke, fever due to heat esxposure, vomiting, diarrhoea, cholera, stomachache, mental exhaustion, fatigue, giddiness, anaemia, nutritional deficiency, cardiac complication.

CIl: There is no known contra indication. SIE: No significant side effect has been observed in proper dosage.

Direction of use: SOml Rooh afza mixed with 200ml ice cold water and take it as and when required. Mix lemon juce to make it more palatable. It can also be used for making Rooh afza lassi, Rooh afza ice cream, Rooh afza custard, Rooh afza faluda, rooh afza jelly, Rooh faza phirni, Rooh afza lemon, Rooh afza samudi, Rooh afza milkshake, Rooh afza thandai, Rooh afza pineapple etc. 300m! bot: 70.00 MRP 750m! bot: 1 30.00 MRP

.:. VITOLIN Syp. A.H Janakalyan38,64 A non alcoholic vitaminised herbal tonic of proven bioavailability in mental performance, anaemia of pregnancy, lactating mothers, liver protection etc.

Ind: Same as Cinkara. Dosage: Adults, 6 tsf twice daily; children, 2 tsf twice daily, or as prescribed by the physician. 100ml bot: 30.00 MRP 100m! bot: 30.00 MRP 250m! bot: 70.00 MRP 450m! bot: 100.00 MRP

Herbal remedy for diabetis & kidney functions.

•:. HAMDARD CHYABANPRASH Touic Hamdard38

Comp: A preparation containing

Chyabanprash is an ideal ayurvedic tonic,

and other precious ingredients.

containing valuable natural ingredients, fortified

Ind: Au effective remedy for diabetis,

with honey, prepared with the ancient wisdom and modern research & technology.

strengthens the functions of kidneys and the ' bladder.

Chyabanprash keeps a man physically fit and

Dosage: 2 tablets once or twice daily.

mentally alert. It restores lost energy.


Chyabanprash is the supplements of vitamins & minerals. It strengthens respiratory system, fortifies immunity & prevents infectious disease.

Comp:

Each 5gm contains: Phyllanthus emblica

5.35gm, Withania somnifera 7 1 .33mg, Vitis

nigrum 7 1 .33mg, Solanum xanthocarpum 7 1 .33mg, Saussurea lappa 7 1 .33mg, Gmelina arborea 7 1 .33mg, Rhus succedanea 7 1 .33mg, Streospermum suaveolens 7 1 .33mg, Cinnamomum zeylanicum 2 1 .40mg, and other ingredients q.s.

Ind: Chyab,mprash is indicated for strengthening the vital organs, improving the

It is

a powerful antioxidant, effective

It

is also effective in malnutrition and degenerative diseases, and improves memory.

CIl:

There is no known contraindication.

SIE:

No significant side effect has been observed

in proper dosage.

rediscovered as a natural source of energy that also offers a unique combination of nutritional benefits. Honey contains vitamins, such as thiamine, riboflavin, vitamin B6 and pantothenic acid. Essential minerals, such as calcium, copper, iron, magnesium, manganese, phosphorus, potassium, sodium and zinc are also found in honey. In addition, several different amino acids, have been identified in honey. Honey also contains several compounds that function as antioxidants, one of which is pinocembrin.

Source: A natural bees honey (from wild). Action & uses: Antibiotic, antioxidant, immunostimulant, quick source of energy, . nutritive, expectorant, tonic.

CIl: There is no known contraindication. SIE: No significant side effects has been observed in proper dosage.

Each 5m! contains- Tribulus terrestris

Ind: Diruetic, urethritis, painful micturition, urinary tract infection� and febrile conditions.

CIl: Contraindicated in case of renal failure. Precaution: Use with caution in case of diabetic patients, children, and during pregnancy.

Dosage: Adult: 2 to 4 tsf 2 or 3 times daily after food with water. Chidren: According to the advice of the physician. HD-santara should be continned at least 3-4 weeks for optimum result. 100m! bot: 19.00 MRP 200m! bot: 37.00 MRP 450ml bot: 75.00 MRP

HERBAL REMEDY FOR NOCTURNAL EMISSION

l OOgm pack: 50.00 MRP

.:. JERNIDE Syp. Hamdard38


Herbal remedy for nocturnal emission


.:. HAMDARD HONEY Liquid Hamdard38

Comp:

aurantifolia 75mg.

7 1 .33mg, Aquilaria agallocha 7 1 .33mg, Solanum

in cough, bronchitis, asthma and tuberculosis.

function and other urinary problems.

alba 150mg, Citrus reticulata 250mg and Citrus

Phyllanthus niruri 7 1 . 33mg, Asparagus racemosus 7 1 .33mg, Terminalia chebula

immunity.

.:. HD-SANTARA Syp. Jayson Natural55

HD-santara is a herbal preparation for diuretic

200mg, Foeniculum vulgare 150mg, Nymphaea

vinifera 7 1 .33mg, Adhatoda vasica 7 L33mg,

Dosage: Adults: 1-2 tsf twice daily. Children: 112 teaspoon twice daily or as directed by the physician.

Honey, nature's original sweetenr, is being

Bambusa

bambos, Rumex vesicarious, Gyrnnema sylvester

:. HD·CHYABANPRASH Syp. Jayson Natural •

Hd-Chyabanprash is a herbal immunoactivator preparation.

Comp:

Chyabanprash is composed of different

herbal ingredients, such as: Phyllanthus emblica, Adhatoda vasica, Piper longum, Solanum

Comp: A preparation of glycyrrhiza glabra, Cascara sagrada and Atropa belladona.

Ind:

Reduces the abnormal sensitiveness and

irritability of the male organ and thus checks seminal discharge. Relieves burning in urination and also prevent nocturnal emission.

Dosage: 1 tsf twice or thrice daily after meals. 100m! bot: 50.00 MRP

xanthocarpum, Aegle marmelos, Desmodium gangeticum, Solanum torvum, Sida cardifolia,

UTEROTONIC &

Saussurea lappa, Aquilaria agallocha, Tinospora cordifolia, Asparagus racemosus, Pterocarpus santalinus, Vitis venifera, & other 44 ingredients.

Ind:

PREGNANCY PROTECTIVE PREPARATION

Immunodeficiency, malnutrition, cough,

cold, bronchial infections, cough associated with tuberculosos, asthma and allergic manifestations.

Cantions: Use with caution in diabetic patients. Dosage: Adult: 4 tsf thrice daily. Children: 2 tsf thrice daily. Treatment may need to be given for 1-2 month. Shake well before use.

.:. FEMOLIN Syp. Jayson Natural55 Femolin is a herbal uterotonic preparation.

Comp:

Each 5m! syrup contains: Saraca indica-

250mg; Withania somnifera (extract)- 1 25mg; Smilax china- 62.5mg; Abroma augusta- 62.5mg;

Direction: 1-2 teaspooful twice daily or as directed by the physician.

100m! bot: 25.00 MRP

Rauwolfia serpentina- 50mg; Ferrum- IOmg.

200m! bot: 48.00 MRP

Ind:

40ml bot: 35.00 MRP

450m! bot: 80.00 MRP

Dysmenorrhoea, amenorrhoea, leucorrhoea,

weakness and inflammation in the uterus and

QIMP-15 (448)

INDIGENOUS MEDICINES irregular menstruation.

ell: Should not use during pregnancy &

.:. MENOTOX Syp. Acme46

Menotox is a poly-herbal combined formulation,

menstruation.

having proven efficacy as uterine tonic. It has a

Caution: Femolin only for female patients. Dosage: Adult: 24 tsf daily after meals. In irregular menstruation, dysmenorrhoea and amenorrhoea, from the last day of the period till the first day of the next menstruation, 2-4 tsf every night. In leucorrhoea, 2-3 tsf to be taken at night. For weakness & inflammation in the uterus, 2 tsf mixed with lukewarm water to be taken at night. To be used for a period.

stimulatory effect on the ovarian tissue that helps regularizing endogenous hormonal secretion,

power.

inflammatory action has a healing effect on the pain. It also known as ashokarista. It is available

Dosage: 1-2 tsf of suparipak powder with a little milk in the morning or 1 tsf with a little milk twice a day- morning and before retiring.

as 200m! syrup in glass bottle.

50gm powder pack: 40.00 MRP

uterus and its antispasmodic action alleviates

Comp: Each 5m! menotox contains extracts of Saraca indica 1.52gm, Terrninalia chebula 1 5 . 15mg, Woodfordia fruticosa 0.24gm,

A preparation for genito-urinary disorders and uterotonic action.

Comp: Prepared from herbal ingredients like Asoka, Withania somnifera, Abroma augusta, Berberis aristata, Rauwolfia serpentina and iron acting solely on female reproductive system.

Ind: Specific treatment for female disorders, such as menstrual irregularity, dys-menorrhoea, leucorrhoea, metritis & uterine inflammation.

Dosage: After menstruation till the starting of next period, 2 tsf to be taken at night for menstrual irregularity and dysmenorrhoea. 2 tsf to be taken at night for leucorrhoea; 2 tsf mixed with lukewarm water be taken at night for metritis. In chronic cases one dose of 2 tsf to be taken in the morning as well.

can also use suparipak for spermatorrhoea,

controls abnormal uterine bleeding. Its anti

Terrninalia belerica 1 5 . 15mg, Nigella sative

:. LEUCOMIN Syp. A.H Janakalyan38,64

general ill-health and weakness. It also increases the appetite and strengthens the kidneys. Males excessive nocturnal emissions and for retentive

200m! bot 47.00 MRP

•

for leucorrhoea, the common cause for female

enhances the repair of the endometrium and thus

l OOml bot: 28.00 MRP 450m! bot 85.00 MRP

preparation to preserve pregnancy. It is specific

15. 15mg, Phyllanthus emblica 1 5 . 1 5mg, Cyperus rotundus 1 5 . 15mg, Mangifera indica 15. 15mg . Zingiber officinale 15. 15mg, Adhatoda vasica 15. 15mg, Berberis aristata 1 5 . 15mg, Pterocarpus santalinus 15. 15mg, Nymphaea lotus 15. 15mg.

Ind: Premenstrual syndrome, Menstrual irregularities, Dysmenorrhoea, Dysfunctional uterine bleeding.

CII: During pregnancy. SIE: Not yet known. Dosage & admin: Adult: 1-2 tsf 1-2 times daily after meal, or as advised by the physician. Children: Not applicable. 200m! bot: 50.00 MRP

.:. RECAL Cap. Deep-Laid 142

Recal restores natural rhythm of uterus; a herbal

PREPARATIONS FOR MENOPAUSAL SYMPTOMS .:. MENOCARE Cap. Acme46 Black cohosh (cimicifuga racemosa) is popular as an alternative to hormonal therapy in the treatment of menopausal (climacteric) symptoms, such as- hot flashes, mood disturbances, diaphoresis, palpitations and vaginal dryness.

Comp: Each capsule contains black cohosh 40mg (dried rhizome).

Ind: Menopausal complaints, premenstrual discomfort.

CII: No significant contraindication is observed. SIE: Occasionally gastric discomfort is observed. Pregnancy & lactation: In pregnancy not

recommended due to an increased risk of

formulation for female reproductive health.

spontaneous abortion. In lactation, not also

Comp: Each capsule contains: Areca catechu,

recommended.

250m! bot 60.00 MRP

Asphaltum, Butea monosperma , "Calcined"

450m! bot: 100.00 MRP

Ironoxide, "Calcined" Pinctada margaritifera ,

Dosage & admin: 1 capsule daily. Or as directed by the physician. Duration of treatment should not be longer than 6 months. Drug inter: Black cohosh (Cimicifuga recemosa)

:. , MASTURIN Syp. Hamdard38

•

A preparation for genito-urinary disorders and uterotonic action.

Comp: Prepared from herbal ingredients like Asoka, Withania somnifera� Abroma augusta, Berberis aristata, Rauwolfia serpentina and iron acting solely on female reproductive system.

"Calcined" Hens egg , "Gum" Acacia arabica.

Ind: Trichomoniasis, Candidiasis, calcium & iron deficiency, Uterine prolapse ( 1 st degree) ,

can potentiate the effect of antihypertensive

CII: 1st trimester of pregnancy. SIE: Excessive dosage can cause constipation. Dosage: 1-2 capsule once or twice daily.

medications. The tannin content of cimicifuga administered iron, resulting in nonabsorbable

50's pack: 200.00 MRP

insoluble complex. Patients who need iron

Ind: Specific treatment for female disord-ers,

.:. SUPARIPAK Powder A.H Janakalyan38

such as menstrual irregularity, dysme-norrhoea,

An ideal preparation to preserve pregnancy. It is

leucorrhoea, metritis and uteri-ne inflammation.

an age-old and well-trusted remedy for many

It is also a uterine tonic.

female uterine disorders. It strengthens the

Dosage: Arter menstruation till the starting of next period, 2 tsf to be taken at night for menstrual irregularity and dysmenorrhoea. 2 tsf to be taken at night for leucorrhoea; 2 tsf mixed with lukewarm water be taken at night for metritis. In chronic cases one dose of 2 tsf to be taken in the morning as well. lOOml bot 33.00 MRP

450m! bot 90.00

MRP

.:. FEMOLAID Syp. Deep_Laid142 Mele is a herbal uterotonic syrup; a natural formulation for female reproductive health.

Comp: Each 5m! contains: Juniperus communis, Saraca indica, Withania somnifera, Plambago zeylanica, Abroma augusta, Smilux china, Nardostachys jatamansi, Vitis vinifera and other ingredients.

Ind: Dysmenorrhoea, Metrorhagia, Menorrhagia,

racemosa may complex with concomitantly

supplementation should be advised to maintain an interval of about 2 hours in administration of these two compounds. 30's pack: 150.00

MRP

uterus and serves as one of the best uterine preparation.!ts main ingredient is betel nut.

Ind: In repeated and threatened abortions due to

the weakness of the uterus. Suparipak is an ideal preparation to preserve pregnancy. It is specific for leucorrhoea, the common cause for female general ill-health and weakness. It also increases the appetite and strengthens the kidneys. Males can also use suparipak for spermatorrhoea, excessive nocturnal emissions and for retentive power.

Dosage: 1-2 tsf of suparipak powder with a little milk in the morning or 1 tsf with a little milk twice a day- morning and before retiring. 50gm powder pack: 80.00 MRP

.:. SUPARIPAK Powder Hamdard38

An ideal preparation to preserve pregnancy. It is an age-old and well-trusted remedy for many

.:. HAMDARD AMLA Hair Oil Hamdard38 Harndard amla hair oil is a tonic for hair. It strengthens hair roots and prevents falling of hair, maintains the natural color and makes them shiny.

It also

imparts a cooling effect of head,

promotes the hair growth and makes the hair silky, soft, dark and lustrous.

Comp: Each 5m! contains: (as extract), Phyllanthus emblica 1.66m!, Sesamum indicum 3.33m!, other ingredients q.s.

Ind: Tyroma, greying of hair, dandruff and insomnia. It also increases the growth of hair and makes them black and shiny.


Metritis.

female uterine disorders. It strengthens the

CII: Not advised during pregnancy. Dosage: lO-20ml twice or thrice daily.

preparation.!ts main ingredient is betel nut.

in proper usage.

100m! bottle: 28.00 MRP

Ind: In repeated and threatened abortions due to

Use & appli: Apply externally on scalp & hair.

450m! bottle: 80.00 MRP

the weakness of the uterus. Suparipak is an ideal

1 30m! bot: 80.00 MRP

uterus and serves as one of the best uterine


QIMP-15 (449)

RESEARCH & DEVELOPMENTS IN MEDICINE & PHARMA CEUTICS:

2. TRENDS IN SOCIOECONOMIC

DEVELOPMENT

QIMP-15 This is a new section opened for presenting the latest research & development docnments in medicine & pharmaceutics, available globally & in Bangladesh_ This is to update the information and knowledge bank of our worthy readers with the latest achievement in the relevant fields_ In this issue, we could provide our readers 'Bangladesh National Health System Profile' as the main article_ We would be very much grateful to our local research & development authorities & pharmaceutical manufacturers, if we get a feedback from them directly or through internet to enrich this section_ With thanks_

Editor

BANGLADESH : NATIONAL HEALTH SYSTEM PROFILE (Courtesy: www.searo.who.int) Source: Internet ('Bangladesh national health system profile' is very important to go through the whole length of its contents. Every medical personnel who are involved in contributing services in this field should know and learn our national health policy as much as possible. But, it's a big volume of about 44 pages which cannot be accommodated in this section of research & development. Some important aspects of this profile are given here in this section.)

1.

attain this goal, many development programmes have been undertaken in the health sector during the past years.

TRENDS IN POLICY DEVELOPMENT

The constitutional commitment of the Government of Bangladesh is to provide basic health and medical requirements to all people in the society. The Constitution of the People's Republic of Bangladesh ensured that "Health is the basic right of every citizen of the Republic," as health is fundamental to human development. Since independence, the government has been pursuing a policy of health development that ensures provision of basic services to the entire population, particularly to the under-served population in rural areas. The successive health plans of the country emphasize Primary Health Care (PHC) as the key approach for improving health status of the people. The goal 'Health for All by the year 2000' has been accepted by the government as a national goal. The past plans in the health sector had endeavored to provide essential healthcare to the general masses. To

2.1 Economic Trends:

There has been a slow but steady increase in GDP per capita from US $ 217 in 1991 to US $445 in 2005. The annual growth rate of the GNP at constant market prices increased from 3.56 percent in 1991 to 5.5 percent in 2002. With the increase in population, the overall public fmancing for health remains the same (National Accounts Statistics, July 2004). About one-half of the total population is poor, with the same picture seen in both urban and rural areas. Income generating schemes are being financed by the Government to make the poor more self-reliant. The human development in Bangladesh is slow and steady as value of Human Development Index (HOI) has increased from 0.417 in 1990 to 0.530 in 2004, ranking the country at 137 among 177 countries. However, in terms of gender development, Bangladesh ranks at 102 among 177 countries, with Gender-related Development Index (GDI) value of 0.524 (Human Development Report, 2006). In Bangladesh, 36 percent population is living with a per capita income below US $ I a day.

2.2 Demographic Trends: The total population of Bangladesh is about 140 million. The annual population growth rate has declined from 2.33 percent in 1981 to 2.15 percent in 1991 and further declined to 1.50 percent in 2002 (SVRS/2002). Similar declining trends are seen over the period of 1981 to 2002 for the crude birth rate (34.4 to 20.9), crude death rate ( 1 1 .5 to 5.9) and total fertility. (BDHS 2004) In Bangladesh, 38 percent of population was under 15 years, 55 percent in the age group of 1559 years and 7 percent in the age group of 60 years and above (BDHS 2004).

Life expectancy at birth: The average life expectancy in Bangladesh has improved from 55 years in 1981 to 65 years in 2002, with 55 years for male and 54 years for female in 1981 to 64 years and 65 years for male and female, respectively, in 2002 (SVRS 2002).

Infant Mortality Rate (IMR): In Bangladesh, Infant Mortality has declined during the period of 1981-2002. In 1981, 1 1 1 infants died per 1,000 live births, which has declined to 87 in 1991 and 53 in 2003 (Source: BBSSVRS 2003)

Maternal Mortality Rate (MMR) : In Bangladesh,Maternai mortality has declined

during the period of 19920-2002. In 1992 it was 4.7 and in 2002 it was 3.8 per thousand live birth. (SVRS/2002)

2.3 Social Trends: The adult literacy rate in the population over 15 years ofage has shown a gradual increase from 1981 (males 39.7% and females 18.0%) to 2002 (males 55.5% and females 43.4%) (BBS, SVRS 2002). Whether this increase has resulted in better utilization of health services is difficult to ascertain.

In Bangladesh, Gross Enrollment Ratio (GNR) in primary education for both sexes is not much different. In the case of males, GNR was 94 percent in 2002-03, and for females it was 98 percent during the same period.

In case of secondary education, GNR for both the sexes has increased from 42 percent in 1998 to 47 percent in 2002-03. The GNR in secondary education for female has increased from 41 percent in 1998 to 50 percent in 2002-03, higher than males for whom the increase is from 43 percent in 1998 to 45 percent in 2002-03 (UNESCO).

2.4 Food supply & nutritional status: The prevalence of low birth weight (weight

,

Ensures analgesic effect at the sta1-ting poi�t of :pain pathway

potenr:pat,*"iller for. ,acute pain ·(> "Dffers the. mo�i , "

' ;

_ . -:

.-

, .. .

.

.(> Ensure$ safety in post,operative pain manage)nent .(> Provides morphine-sparing effects .(> Ensures patient satisfaction -(>

Ensures wider coverage in pain management

IC 8IOPHARMA •••• 11'• • I• •• 'w... ........

.www . bioph a rmab d . c om

Asmolex-75,78 Asmont-85 Asnil-75 Asorin-66 Aspartame-348 A-spasm-8,9 Aspel-SR-328 Aspin-67,236 Aspirin-65 Aspra-17 Asta-240 Asthmolin-75 Astin-72 Astiva-72 Astro-Z- 3 1 2 Asul-76 Asuma-308 Ataq-2 1 O Atarax-269 Atasin-72

Atorvastatin-7 1

Avotil- 1 l 5

Azole-234

B-clor- 176

Atova-72

Avudin-21 9

Azomac- 198

Bec-330,343

Atovin-72

Axet- 178

Azovit gold-346

Beclod-86

ATP-237

Axetil- 178

Aztor-72

Beclomethasone-86,432

Atracurium-394

Axim- 178

Aztreonam- 192

Beclomin-86

Atralin- l 1 1

Axinat-79

Aztrum gold-346

Beclovan-266

Atrizin-271

Axinat-F-88

Aztrum silver-347

Beconase-432

Atrol-27 1

Axodin-272

Aztrum-PN-344

Beconex-325

Atropine OSL-372

Axon-187

A-zyme-30

Beconex-M-342

Atropine-6,41 9

Axosin- 1 87

Azyth- 180

AU- 1 7

AZ opthalmic-408

B.

Beconex-ZI-3 14 Becoson-325 Becoson-M-342

Aumi- 1 7

Az- 197

Austomin-3 6 1

Azactam- l92

Auxil- 1 62

Azalid- 197

B.C.G-384

Becosules gold-329

Avalon- 197

Azathioprine-372

B-50 forte-325

Becosules-325

Avas-72

Azecol-424

Babica-438

Beforte-325,341

Avastatin-72

Azelaic Acid-296

Babivit-33 1

Beforte-M-342

Avastin-74,367

Azelast-430

Babiz-341

Belocef- l 7 2

Avatan-422

Azelastine-430

Baby saline-352

Belox-162

Avaxim-3 8 1

Azelec-297

Baby zinc-339

Ben-A-234

Becospray-433

Gigacef ®

QIMP-lS (SOl)

Benadip-5 1

Betamycin-286

Biofez- 3 1 4

Benalgin plus-240

Betanic-330

Biopen-VK- 160

Benda-DS-234

Betanol-35

Bioron plus-309

Cefradine Capsule, Ped. Drops & Susp.

iii

PACI F I C

Bendex-233

Betasec-35

Bioron-306

Bendil-277

Betasef-l72

Biotrex-233

Benemid-264

Betason-N-286,428,433

Biotrim-204

BP zinc-339

Benfloxin-212

Betavate-284

Biovit Gold-346

BpcaI-332,335

Bromid-7

Benmet-228

Betavate-CL-286

Biovit PN-344

Bpclox-1 6 1

Bromocriptine Ricter-

Benocef- l72

Betavate-N-286

Biovit silver-347

Bpdon- l l

125

Benosol-283

Betaxol-420

Biovit- 3 1 5 ,325,329,33 1

Bpdox- 193

Bromocriptine- 1 25

Benoxil- 1 66

Betaxolol-420

Biovit-M-342

Bpfort-325

Bromodel-125

Benprox-207

Betnelan- 146

Biozinc-B-341

Bpfort-M-342

Bromofen-416

Bensal-282

Betnioson-284

Biozinc-I- 3 1 5

B-plex-325

Bromolyt-92

Bentid- 14

Betnoson-284

Biozyl-228

B-plus-325

Broncomet-92

Bentol-280

Betnovate-284

Bipinor-38

Bpmox-166

Broncotrol-76

Benvit-B-325

Betoptic-S-420,428

Bisacodyl-27

Bpnol plus-49

Brondyl-76

BenzaIic-282

Betricin-4 1 3

Bislol-36

Bpnol-35

Bronil-76

Bromhexine-92

Benzapen- 161

Betricin-N-4 1 3 ,428

Bisoprolol-36

Bptetra-193

Bronium-99

Benzathine penicillin-

Betson-N-286

Bivacyn-279

Bptrol-27 1

Bronkolax-76

161

Beucal O-335

Bivaplex-T-325

Bpxen-259

Brospan-7

Benzit- 102

Beuflox-207,409,

Bizi-3 1 5

Bp-Z- 198

Brox-92

2 5 0 mg, 500 m g c a p s ", l e & 60 m l & 1 00 m l P F S CD

CD CD

CD

CD

CD

Skin & soft tissue inf�ction Osteomylitis Staphylococcal septic arthritis Staphylococcal septicemia in both adults and neonates Upper & lower respiratory tract infection

10 BIOPHARMA

Prophylaxis during major surgical procedures

Co ... ... l t t . d t. S a r v l .. . ... . . . . . ..

www. b i o p h a r m a b d . c o m

Benzith- 198

4 1 4,429

Bleocin-363

Brace- l 7 2

Broxidil-92

Benzocaine-246

Bevacizumab-367

Bleomycin-363

Breton-79

Broxine-92 Broxolin-92

Benzoin tincture-95

Bevit-325

B-Mycin T-279

Brevoxyl-297

Benzoyl peroxide-297

Bexidal-270

BN-4 1 3 ,428

Brimo-421

Broxolit-92

Benzyl-benzoate-283

Bexitrol-79

Bonacal-332

Brimonidine-420,42 1

Broze-99

Beonac-252

Bexitrol-F-88

B-One-321

Brimopres-422

Brozep-99

Beovit-32 1

Bexsul-282

Bonec-332

Brizy-78

Brunex-94

Berdinal-122

Bextram gold-346

Bonemass-357

Broad-76

Btiron TR-3 1 2

Berin-321

Bextram-32 1 ,344

Bonflex-361

Brodamox- 166

BTlin-76

Besone-284

Bfenac-4 1 6

Boni 0-335

Brodil-76,78

Budeson-87

Besone-N-286

BicaIutamide-375

Boni M-337

Brofex-90

Budesonide-86,433

BestaI-3 1 1

Bic-F-3 1 1

Boni-332

Broket-84

Budicort-87,433

Bestcef- 1 8 1

Bicozin-314,341

Bontonic-337

Brolax-76

Bufen-256

BetacaI-49

Bigmet- 135

Bonviva-357

Brolin-82

Bundural-La- 1 6 1

Betacin-N-413,428

Bilco-92

Bopam-99

Brolyt-92

Bupi-399

Betahistine- 1 1 5

Bimuty-339

Bost-323

Bromazep-99

Bupicain-399

Betaloc-38

Binoclar-200

Botox-265,304

Bromazepam-99

Bupivacaine-398,399

Betameson7N-286

Biocef- 176

Botulinum toxin-265,304

Bromergan-125

Bupropion- l 1 1

Biocid -2

Boxitrol-4 1 2

Bromex-92

Burnsil-280

Biocin-268

Boxol-92

Brornfenac-4 1 6

Buscogen-7

Betamethasone-

1 44,284,413,428

Trifix®

Cefixlme Capsule & Susp_

QIMP-lS (502)

ii

PACI F I C

Calcium salts-355

Calvimax-335

Cardilock-35

Calcium-332,333,335

Calypsol-388

Cardinex-65

Calcium antacid-5

Camiton-61

Cardioplegia soln-397

Calcium-D-335

Camlodin plus-49

Cardipin plus-49

Calcium-J-333

Carnlodin-57

Cardipin-57

Buscon-7

Calamine-278,292

Calcium-M-337

Camlopril-5 1

Cardipro plus-50

Busulphan-362

Calate-332

Calcizen DS-333

Campto-370

Cardipro-35

Butacin-7

Calbeta-49

Calcizen-332

Canazole-225

Cardiron-32

Butamirate citrate-434

Calbo-332,336

Caldical-333

Candesa-42

Cardisef-35

Butapan-7

Calbo-C-334

Caldical-D-335

Candesartan-41

Cardival-44

Butason-7

Calbo-D-335

Caldil-333,335

Candex-224

Cardivas-36

Butastat-7

Calbon D-335

Caldivit-335

Candid-225

Cardivit-329

Butenafine-282

Calbon M-337

Calfeed-333

Candinil-225

Cardizem-58

Buterol-79

Calbon plus-337

Calfor-333

Canider-58

Cardo plus-53

Butramin-128

Calbon-333

Calfor-D-335

Canstat-225

Cardon-43

Butyl-K-7

Calboplex-337

Calium plus-335

Canta-333

Cardopa-63

B-Vit-4-325

Calcarb-333

Calium-333

Canten-28I

Cardopril-39

B-Zn-339

Calcefer-334

Caljuven-333

Cantrirn-281

Cardopyrin-66

Co

Calchek-49,57

Calkid-333

Capcee-328

Cardosia-57

Calci-332,333

CaIm-99

Capecitabine-364

Care-330

Calcicar-333

Calmax-333

Capflu- 162

Caress-297

C-4-334

Calci-D plus-335

Calmet-333

Capotril-39

Carmapine- 1 1 8

Cab-57

Calci-D-333

Calmet-D-335

Caprolex-68

Carmina-437

Cabisol-283

Calciferol-3 1 9

Calmet-M-337

Caprolisin-68

Carminative mixture-6

Cabonat-332

Calcifil-333

Calmi-D-339

Capsaicin-247

Carminative prepns-6

Cabretol-1 1 8

Calcim-333

Calock plus-49

�apta-193

Carmolin-437

Cac-334

Calcin-333

Calock-57

Captopril-39

Carnitab-62

Cacetor-5 1

Calcinate-332

Caloren-320

Carbamazepine-1 1 8

Carniten-62

Cadmin plus-337

Calcin-D-335

Calos-333

Carbapenem- 1 90

Carnocide-235

Cadmin-335

Calcin-M-337

Calpin-49,57

Carbazin- 1 1 8

Carocet-330

Cadnyl-40

Calci-pot-333

Calpo-333

Carben-333

Carofol Z-3 1 4

Cafceta-240

Calcipotriol-29 1

Calpo-D-335

Carben-D-335

Carotone-plus-446

Cafedon-240

Calci-R-332

Calsil plus-335

Carbirnazole-145

Carsec-35

Cafenol-240

Calcirol-3 1 9

Calsil-333,337

Carbizol-145

Cartifit-3 6 1

Caffo-240

Calcitate-332

Calson-332

Carbocal D-335

Cartigen-361

Caf-N-240

Calciton-333

Caltate-332

Carbocal-333

CartiI-361

Caid-66

Calcitonin-356

Calton-332

Carbocisteine-93

Cartilage-36I

Cal D plus-337

Calcitriol-320

Caltonic-333

Carbolin-93

Cartilex-361

Cal D-335

Calcium ambee-332

Caltrol-32

Carbomet-3 16

Carv-330

CaI-332

Calcium gluconate-332

Calvasc-57

Carboten-93

Carva-66

Calac-332

Calcium jayson-332

Calvimax plus-337

Cardil-58

Carvedilol-36

r

QIMP-15 (503)

Macazi(@

iii

Carvetab-36

Cefadroxil- l 7 1

Ceftid- 1 8 1

Carvida-36

Cefadyl- 1 8 1

Ceftipime-190

Carvipress-36

Cefalex-170

Ceftizone-1 89

Carvista-36

Cefasia- l72

Ceftriaxone-187

Casalt-333

Cefazid- 1 86

Ceftrix-187

Casalt-D-335

Cefdinir-180

Ceftron- 1 87

Ceporex-170

Chemofen-256

Casodex-37 5

Cefdox-185

Cefu-M-178

Ceporin- 1 7 1

Chemomycin-193

Castorin-442

Cefepime-1 89

Cefurim- 178

Cepoxid- 185

Chemophenicol-408

Catapres-33

Ceferon- 1 8 1

Cefuroxime- I 77,435

Ceproval- 173

Chewce-328

Catopil-39

Cefetamet- 1 80

Celbarin-223

Cerenin-61

Chewrol- 3 1 0

Catrix-424

Cefida-180

Celeco-250

Cereton-61

Chicken pox vaccine-

Cavapro-42

Cef1Ill-3- 1 8 1

Celecoxib-249

Cerevas-61

378

Cavazide-5 3

Cefix-1 8 1

Celenta-250

Cerivin-61

Chloral hydrate-97

Cavelon-36

Cefixim-1 8 1

Celin-328

Cero-207,409

Chlorambucil-362

Cavic-C plus-336

Cefixime- 1 8 I

Celipress-37

Cerodex-4 I 4,429

Chloramex-408,427

Cavic-C-334

Cefixon-1 87

Celiprolol-37

Cero-HC-429

Chloramphenicol-

Cavinton-61

Ceflin- l72

Cellcept-373

Cerox-A- 178

408,427

Caviton-61

Ceflon-176

Celofen-249

Ceroxime- 178

Chlorhexidine-302

Cazep-1 I 8

Cefmix-1 8 I

Celox-R-250

Cesil-27 1

Chlorodex-4 1 4

C-bon-328

Cefobac-178

Celudex-4 1 3 ,428

Cesonide-87

Chlorool-201

CCB-57

Cefobid-185

Cemix-182

Cetal-237

Chloroquine-2 3 1

Azithromycin Tablet & SUsp.

PAC I F I C

... Offers rapid and powerful pain relief ... Only NSAID with central and peripheral aCtion .

... Drug of choice for the management of acute and chronic pain

;,.. UnUke COX-2 lnhibitor It does not cause cardiovascular complications "' Excellent safety profile

••__ Itl•• ••••rv•••••••••• w w w . b i o p h a r m a b d . c o rTi

Chloroxylenol-302

Ceb-330

Cefocef-1 8 I

Cemoxin-166

Cetam plus-240

Cebac-A-178

Cefodim- 1 85

Cenet-3 3 3

Cetam-237

Chlorphen-20 I ,408,427

Cebex- 1 8 I

Cefodox-185

Cenolon-433

Cetirizine-270,27 1

Chlorpheniraine-267

Cebrotonin- 127

Cefomin-1 85

Centagan-268

Cetizin-27 1

Chiorpromazine- I O 1 , 1 1 6

Ceclofen-249

Ceforan- 1 85

Centamol-239

Ceto-330

Chlorthalidone-45

Cecon-328

Cefore-435

Centoxin-33

Cetox-330

Cholecalciferol (D3)-289

Cecona C-249

Cefotax- 1 84

Centrim-204,205

Cetra-330

Cholera fluid-353

Cednir- 180

Cefotaxime-184

Ceodin- l72

Cetril-271

Cholera saline-353

Cedofax-185

Cefotil-178

Ceodin-173

Cetrin-271

Cholera vaccine-378

Cedol-228

Cefozil- l77

Cepa- 170

Cetrorelix-157

Cholinor-71

Cedril-1 7 1

Cefpirome- 190

Cepdoxim- 1 85

Cetrotide- 157

Chuben-234

Ceegram-328

Cef-plus- 1 8 1

Cephalen-170

Cetzin-271

Ciclesonide-87

Ceemet-328

Cefpodoxime-184

Cephalexin- 170

Cevalin-328

Ciflox-207,409,427

Ceeta-328

Ceframed- l72

Cepharol- 170

Cevion-328

Cilest- 158

Ceevit-328

Cefrasyn- l72

Cephaxin-170

Cexitil-178

Cilocin-207

Cef-3- 1 8 1

Cefroxil-178

Cephid- 173

Cezin-27 1

Cilostazol-61

Cefaclor- 176

Cefrozil- l77

Cephradex-173

C-fenac-252,4 17

Cimetidine-1 3

Cefad- l 7 2

Ceftazidime-1 86

Cephradine-l72

C-gum-328

Cinalid-198

Cefadin- l72

Ceftazim-186

Cephran- 1 7 3

Chear- l I l

Cinamak- 194

Cefador- 1 7 1

Cefticlor- l77

Ceporal-170

Chemagyl-228

Cinarin- 1 1 4

QIMP-15 (504)

Cinaron- 1 14 Cinaryl- 1 14 Cinarzin- 1 14 Cinazin- 1 14 Cinet-333 Cinkara-446 Cinnarizine- 1 14 Cinoderm-288 Cinomyst- 1 1 4 Cinon-288 Cinquin-232 Cip-207,409,414 Cipcin-207 Cip-D-429 Ciplon-207 Cipoxia-207

Clenol-302

Clonazepam- 1 19

Ciozapine- I O 1

Clexane-65

Clonidine-33

Clozol VT-406

Clindacin-201 ,296,406

Clont-66

Clozol-28 1

Clindamycin-20 1 ,296

Clontas-67

Clozoson-286

Clindax-201

Clopid-67

Clozox-28 1

Ciproquin-208

Clinex-296,298,405

Clopidogrel-66

CNV-32 1

Cipro-S-208

Clit-23 1

Clopidol-67,68

Coaltar-292

Ciprotec-208

Clizin- 1 14

Clopigel-67,68

Co-amoxic1av-169

Ciprox-208,409,427

Clob-99

Clopilet-67

Coartem-232

Ciproxen-208

Clobac-l77

Clopirel-67

Co-careldopa-125

Ciproxim-208

Clobam-99

Clopixol acuphase- l03

Cod liver oil-320

Ciproz-208

Clobazam-99

Clopixol-103

Cod plus-321

Ciprozen-208

Clobederm-286

Cloram-408

Coderin-370

Ciprozid-208,409

Clobenate-286

Cloram-D-414

Codex-94

Ciprozid-DX-4 14

Clobeon-287

Cloramin-268

Co-diovan-55

Cipzin-27 1

Clobesol-286

Clorel-67,68

Codlivit-321

Cirizin-281

Clobetasol-286

Cloron- 1 19

Codopa- 125

Cisplatin-368

Clobetasone-287

Closon-286

Codvit-320

Citalex- l08

Clobex- 1 6 1

Closten-28 1

Codvita-321

Citalon- 108

Clobid-99

Clostylbegyt- 1 39

Codyl-94

Citalopram- l 0 8

Clocef- l 7 7

Clotech-D-23

Cofdil-94

l,eveJ in Il

l tI1e o Otly

"

Atorvastatin 1 0 mg & 20 mg tablet

,

A

, A

the risk reduction of Myocardial i nfa rction

A

the risk reduction ,of $troke a nd Angina , the managem�l1t 9f i:1yperten�ion

A A

Cipro-207 Cipro-A-207,409 Cipro-B-207 Ciprobac-207 Cipro-C-207,409 Ciprocap-207 Ciprocin-207,409 Ciprocort-429 Ciprofloxacin206,408,427 Ciprol-207 Ciprolex-208 Ciprolyn-208 Ciprom-208 Cipro-M-208 Cipromet-208 Cipromin-208 Cipron-208 Cipronil-208

the risk reduction of M ixed Dyslipidemia

A

A

Ciprin-207,409

the management of Hypercholesterolemia

the risk reductioti bf MY9cardiai

the risk reductiort of llf"t,ar,nc,-Iar

Citapram- 108

Clodal-281

Clotinil-67

Cofex-94

Citavit-328

Cloderm-281

Clotrim-281 ,406

Coflex-441

Citin-271

Clof-249

Clotrimazole-

Coflyt-92

Citizen-271

Clofamol-240

281 ,406,412,428

Cofnil-94

Citrol-271

Clofen-252

Clotrizole-28 1

Cofno-91

Civic-ZF-3 1 6

Clofenac DT-254

Clovate-286

Cofrid-94

Civodex-4 14,429

Clofenac gel-255

Clovate-N-287

Cofson-94

Civox-208,409

Clofenac-252,41 7

Clovir-413

Colax-99

Cizin-271

Clofenta-249

Cloxa- 1 6 1

Colaz-235

C-Jointin-361

Clofina-263

Clox\!cillin- 1 6 1

Cold-B-92

Clacin-200

Clofranil- 1 07

Cloxafu- 162

Coldex-94

Clamox-166

Clognil-66,67

Cloxapen- 1 6 1

Coldflu-90

Clarex-275

Cloles-72

Clox-F- 162

Colicon-6

Claricin-200

Cloma- 1 1 9

Cloxicap- 1 6 1

Colik-7

Clarigen-273

Clomin-268

Cloxima- 1 6 1

Colipan-7

Clarin-200

Clomiphene- 1 5 2

Cloxin- 1 6 1

Colitrol-320

Clarison-200

Clomipramine- l 06

Cloxi-Z- 1 6 1

Colostat-72

Clarithromycin- 199

Clonac-252

Cloxmet-161

Combicard-49

Clas-67

Clonapin- 1 19

Cloxpen- 1 6 1

Combined oral pills- 1 5 8

Clavix-66

Clonatril- 1 1 9

Clozam-99

Combipen- 160

QIMP-15 (505)

Combiplat-68

Cosium-99

Cural-270

Combivit-325

Coslev-2 1 2

Curex-283

Comet- 1 3 5 , 1 3 6

Coslox-1 6 1

Curin-273

Comipen-153

Cosmofer-307

Curon-395

Compimet- 142

Cosmotrin-297

Cusef- 1 73

Compiron-306,307

Cosnap-259

Cutisone-288

Daflon-29,64

Complavit-325

Cospra-2 1

Cutivate-288

Daivonex-291

Comprid- 133

Costin-333

CV nor-49,57

Dalacin-C-201

Comtan- 125

Cosvit TR-3 1 1

C-vitera-328

Dalteparin-65

Comvit-B-325

Cosy- l l

Cyanocobalamin-3 17

Danamet-158

C-on-328

Cotrazen-205

Cyclid- 127

Danazol-157

Conasyd-282

Cotrim-205

Cyclobenzaprine-267

Dancel-301

Conaz-225

Co-trimoxazole-204

Cyclogest- 150

Danium-93

Conazole-225

Co-try-205

Cyclopan-7

Daosin- 1 3 3

Concor-36

Cots-205

Cyclophosphamide-362

Dapsone-216

Conolia- 134

Cotson- 146

Cyclosporin-294,373

Darmol-282

Consucon-133

Coversyl-40

Cyclovex-413

Dawa-ul-misk-439

Contilex-361

Cox-B-250

Cyclovin-7

Dayhista-270

Contine-82,83

Coxia-255

Cyclox- 1 6 1

Dayprox-260

Convules-123

Coxib-250

Cynocort- 147

Dazine-280

Copex-94

Coxitor-255

Cynodex-3 1 7

D-butamol-76

Cophilex-94

Cozaril-43

Cynomin-3 1 7

DCF-252

Cophyl-94

CP- 1 85

Cynomin-H-317

Dc1ot-67

Corangi-60

Cpcal-333

Cypor- l 7 1

D-cort- 145

Corbic-2 1 2

Cpdom- l l

Cyporin-423

D-cough-90

Cordarone-32

Cpfen-256

Cyproheptadine-269

DC-plus-240

Cordil-57

Cpfero TR-309

Cyrin-267

D-dopa- plus- 125

Corel-36

Cpflox-208

Cytapen-V- 160

Debion-323

Cortaid-146

Cpmol-239,240

Cytaplex-326

Debolin-319,320

Cortan- 146

Cpmycin- 1 7 8

Cytaplex-M-33 1 ,342

Decabolon- 152

Cortider-288

Cpvit-326,329

Cytarabine-365

Decabutamol-76

Cortimet-288

Crezyme-30

Cytocid-2

Deca-durabolin- 1 52

Cortisol-416

Crinone-149

Cytomis- 1 6

Decafen-252

Cosat-205

Criptin-125

C-Zinc-339

Decafos-146

Cosben-235

Crodex-283

CZM-337

Decagyl-228

Coscef- 173

Cromolin-41 8 ,432

Cosdox- 193

Cronix-283

Cosec - 1 7

Crotamiton-283

Cosfenac-SR-252

Crystal violet-304

D.P.T.-379

Decatrim-205

Cosfez TR-3 1 2

Crystapen-V- 160

D.T Vaccine-379

Decetamol-237

Cosflu-225

CTZ-271

Dactus- 1 34

Decoff-91

D. .

Decal-332 Decalor-414 Decason- 146

De-cold-92 Decomit-86,433 Decorex-94 Dedom- l l Deferasirox-308 Defim-3 - 1 82 Deflam-256 Deflin-438 Deflox-208 Deflux-l l Deglobin-445 Degram-400 Degut- l l Dela- 1 3 3 Delacin-193 Delentin-235

Deleta- 102 Delice-284 Delipid-7 1 Delorin-275 Delot-275 Deloxi-109 Deltacort- 146 Deltapred- 146 Deltasone- 1 46 Deltasone-N-416,429 Demacro- 198 Demarin-260 Demorhoid-439 Demox- 166 Demoxil- 166,169 Denac-50-252 Denamine-268 Denicol-414 Denitine- 14 Denver- 1 82

C'a l � D® Calcium + Vitamin D Tablet ', ' ' . , ' ,

QIMP-lS (S06)

iii

PACI F I C

Dex-I-250

Diamicron-MR- 1 3 3

Diconten-1 02

Dexibu-250

Diamin- 136

Dicot-290

Dexibuprofen-250

Diamine penicillin- 1 6 1

Dicycloverine-6

Dexifen-250

Dianak-353

Didryl-269

Dexipro-250

Dianide-25

Dieta-134

Deorix-284

Desbac- 1 85

Dexit- 102

Dianonn- 1 38

Diethyl carbamazine-235

Deotrex-233

Desferal-308

Dexitra-91

Diapiotab-1 39

Diethyl ether-388

Deotrim-205

Desferrioxamine-308

Dexketoprofen-250

Diapizi- 1 35

Dietil- 128

Depanil- 1 19

Deslor-275

Dexodel-9 1

Diaplus-1 35

Difen-252

Dephan_90

Desloratadine-27 5

Dexon- 146,4 1 4

Diaprid- 1 3 3

Difenac-252

Deplex-325

Deslorin-275,277

Dexoride-353

Diapro-1 33

Difin-269

Depnil- 1 02

Desmark-275

Dexpoten-91

Diar-25

Diflu-225

Depnox- 1 1 2

Desodin-275

Dexsol-90

Diarepa- 1 3 8

Diflucon-225

Depol extra-240

Desol-275

Dextason- 146

Diaryl-134

Difol-TR-309

Depol-237

Desolon- 158

Dextran-354

Diasol-IV-353

Digac-437 Digel-2

Depomedrol-147

Deson-146

Dextrasal-mini-352

Diasweet-348

Depresil- 102

Desta-5-275

Dextrobac-4 1 5

Diatag- 1 39, 140, 1 4 1

Digoxen-33

Deprex- 1 04

Destaein-275

Dextrolae-354

Diatrol- 1 3 3

Digoxin-33 Digreen� 1 3 3

Depyrin-237

Detae-14

Dextromethorphan-90

Diavix-21 9

De-rash-293

Detens-l 00

Dextropac-352

Diazepam-98, 1 1 9

Dihert SR-434

Derat-275

Detrusin la-403

Dextrosal-353

Diazimet-98

Dilamide-230

www . b i o

hormobd.com

Derbicil-282

Dettol-302

Dextrosal-baby-352

Dibenol- 1 33

Dilapress-36

Derfin-229,282

Deu- 17

Dextrosal-iso-353

Diealtrol-320

Dilast-47

Denna-225

Devolae-27

Dextrose saline-353

Dieef- 173

Dilate-41 9

Dennaeort-286

Devomit- 1 1 5

Dextrose-349,352,353

Dieephin-187

Dilatol-76

Dennacure-293

Dexa-146

Dezide-48

Diclo-50-2525

Dilator-79

Dennalog-288

Dexaeol-414

D-fen-245

Diclofen-252,417

Dilatrend-36

Dennanix-284

Dexaeort-4 14,429

D-fix- 1 82

Diclofenac

Dilgard-36

Dennasim-281

Dexadron-414,429

D-floxin-208

diethylarnmonium-255

Diliner- 109

Dennasim-VT-406

Dexaguard-4 1 4

D- fo- 136

Diclofenac free acid-254

Dillol-36

Dennasol-286

Dexam-146

DFX-208

Diclofenac potassium-

Diloeard-36

Dennasol-N-287

Dexamet- 146

Diab- 1 3 3

254

Dilock-D-252

Dennatas-286

Dexamethasone-

Diabex- 1 3 6

Diclofenac sodium-

Diloxanide furoate-230

Dennex-286,289

145,4 1 3 ,429

Diabid- 1 33

25 1 ,4 1 6

Diltiazem-58

Dermidex-288

Dexamin-146,414,429

Diaetin- 1 3 5

Diclon-252,41 7

Diltizem-58

Dennin-282

Dexan- 146,414

Diafer- 1 36

Diclonae-252

Dilyt-92

Dennoban-279

Dexaqua DS-352

Diagle- 1 33

Diclonil-252

Dilzem-58

Dennovate-286,287

Dexaqua-352

Diaglit- 1 39

Diclora-252

Dimenta- 1 29

Dersa-280

Dexasone-146

Dial-58

Diclorex-252

Dimerol- 1 3 3

Des-275

Dexatab-146

Dialon- 134

Diclo-TR-252

Din-274

Desatrol-275

Dexehlor-41 4

Dia-M-136

Dieon- 1 3 3

Dinae-TR-252

QIMP.15 (507)

Cal-D® Plus

ii

Dinakion-69

Dobutamine-62,63

Doquin-208

DinarA39

Docetaxel-368

Dora·275

Dinxi-102

Docosanol-280

Dorel-67,68

Diohes-29

Doctrim-205

Dorenta-269

Diola-36

Dofixim- 1 85

Doresa-26

Diorin·29

Dolabi·447

Doridon- l l

Drota-8

Dydeca- 152

Diosmin-29

Dolan-243

Dormicum-96

Drotapan·8

Dymet-228

DiovanA4

Dolcin-268

Dormir- 1 l 2

Drotaverine·8

Dyno·271

Dip-250

Dolocef· 173

Dot-8

Drovin-8

Dyroma-438

Diphedan- 122

Dolocid-2

Doumeal-2

Droxigel·plus·2

Dyrotab·438

Diphenhydramine-269

Dolonac-249

Dover·8

Droxil- 1 7 1

Dysedin· 170

Diphtheria vaccine·378

Dolonil-243

Doxa- 193

D'Tox·330

Dysma-9

Dipicard-49

Dolopen- 162

Doxacil- 193

Dudan- 1 2

Dysnov- 1 2

Diplor-49,57

Doloran-243

Doxacin-193

Duet-240

Dyzin-27 1

Diprobet-285

Dolorex-243

Doxcline- 193

Dugal-14

Fie

Diproxen-259

Domar· 1 1

Doxepin-107

Dulac-27

Diretic-48

Domidon- l l

Doxicap-193

Dulcolax-27

E.

Dirin-7

Domilin- l 1

Doxicen- 193

Dulox-109

Easium·98

Dirozyl-228

Domilux· 1 1

Doxicin- 193

Duloxen- 109

Eba-330

Dirucom-48

Domin-1 1

Doxicline· 193

Duloxetine- l09

Ebac- 195

Dirusid-48

Dominat- 1 1

Doxico- 193

Dumaflox-208,409

Ebazan· I OO

Disopan- 1 19

Dominol- l 1

Doxicon-193

Duobon·360,361

Eben-235

Disopyramide-32

Domiren- l l

Doxigen-193

Duofilm-295

ECA-330

Dispazinc·339

Dompa- 1 1

Doxikem- 193

Durabolin- 152

E·cap plus-330

Disprin-66,236

Dompen- l 1

Doxilin· 193

Duracef- 182

E·cap-329

Distamin-268

Domperidone- l 0, 1 1 6

Doximet- 193

Durakinase-68

E-capro-68

Disys plus-55

Dompi· 1 1

Doxin- 193

Duralax-27

Ecena·249

Disys-44

Domsil- l l

Doxipan- 193

Duran- 14

E-cepra· 173

Dithranol·292

Domstal· l l

Doxisyn· 1 94

Durazol-235

Ecin-195

Divastin-72

Don-A· 1 1

Doxizen-194

Durex-442

Eclamsil·338

Diverin-7

Donadin-303

Doxorubicin-363

Duric-264

Eclo-287

Diversa gold·346

D-one-414,429

Dox-P-194

Durogesic-393

E-clor· l77

Dix extra·263

Donepezil- 129

Doxseem- 194

Durol-37

E-cod-321

Dix plus-252

Donor-330

Doxy-A- 1 94

Dutamax-402

Ecoderm·281

Dixicon-400

Dopac-193

Doxycycline- 193

DutasterideAO 1

Ecoderm·TA-290

Dix-TR·252

Dopadon-l l

Doxylin-194

Duven·8

E-cof-94

Dixxar-9 1

Dopamine-63

Doxysina- 194

Duxil-60

E-col-408

D-Iac-25

Dopegyt-34

Doxyson- 194

Duzela- 109

Ecomet-281

D-metro·228

Dopen-166

Dpdone-12

D-vital-323

Econal·281

Dobuject-63

Dopin-57

D-plus-277

Dyaferon-306

Econate·281

Dobumin-63

Dopon- 1 1 , 1 2

DPT-379

Dyalyte-404,405

Econate-GA06

Bimuty®iii Elemental Zinc

Dispersible Tablet & DS Syrup

.

PACI F I C

QIMP-15 (508)

Elimox- 166

Enalapril-39

Eliporent-94

Enaril-40

Epipen- 1 2 1

Eliprazole- 1 7

Enazol plus-290

Epirubicin-363

Epilim-123

Eliprox-208

Encilor-274

Epitra- 1 l9

Eliroxime-178

Encoprin-66,236

Epival- 1 l 2

Econate-plus-290

Edruplex-323

Elitrizine-271

Encorate-123

Econate-VT-406

Epl plus-3 1 6

Edruvit-331

Elizinc plus-3 1 1

Endemali-437

Epl-3 1 1

Econazole nitrate-406

Edruvit-M-342

Elmin-235

Endoxan-362

Eplerenone-47

Econazole-28 1 ,406

Edry- 195

Elo-274

Endurex-442

Epleron-47

Ecoren VT-406

Efavirenz-2 1 8

Elocon-290

Energin-330

Ecoren-28 1

Epnil- 1 l9

Efdinir- 1 80

Eloxatin-370

Energy-B-326

E-pod-1 85

Ecoren-T-290

E-fenac-253

Eltroxin- l 44

Enfalac-348

Epoetin alfa/beta-

Ecosone-290

Efepime-190

Elzer- 1 29

Enfamil-348

3 1 8,3 1 9

Ecosprin-66,68,236

Efin-94

Elzyne-437

Engerix-B-382

Eposin-367

Ecotin-330

Eflam-256

Em- 195

Enliven-370

Epoxim- 185

Ecotin-S-330

E-flu-162

Ema-20

Enocef- 188

Eprel-266

Ecotrim-290

Eflucin-162

Emcil- 170

Enoclox- 1 62

Eprex-3 1 9

Ecovit-329

Efol-ER-3 1 2

Emcon-159

Enol-35

Epson- 100

Ecovit-S-329

Efrad- 173

Emedon- 1 2

Enoparin-65

EPZ- 1 7

Ecox-255

Efynal-329

Emego- 1 14, 1 l 5

Enoxaparin-64

Equate-342

Ecozol-2 8 l ,290

Egen- 195

Emenil- 1 l4, 1 1 5

Enplex-326

Equin- 148

•

•

� ,

\ /

B enzlt t r a c e n

depression & allXiety ' to treat '" eXcellent combI.nation

Reduces the symptoms of anxiety and depression • H as stabil izing properties • Reduces fear • I n creases drive • Relieves tiredness and stress • Relieves irritabil ity or ag itation • I m p roves qual ity of sleep

0Cl BIOPHARMA

0 ......... I • •• Fl" •• • • • 111 •• www . b i o p h a r m a b d . c o m

Ecozol-VT-406

E-gold-329

Emenor- 1 l 5

Ensal-282

Equra-299

EC-plus-330

E-ket-391

Emep-20

Enso- 2 1

Eracef- 1 88

Ecvit-330

Eladin-274

Emetron-1 l 8

Ensure-349

Eracillin-K- 1 60

Edeloss-48

E-Iax-27

Emez- 17

Entacapone-125

Eradex-274

Edemide-48

Eldopaque-300

Emezin- 1 l4,1 l 5

Entacyd plus-3

Eramin-268

Edenil-48

Eldoquin-300

Emidom-12

Entacyd-2,3

Eras-66

Edical-333

Eleclob- l00

Emistat- 1 1 8

Entecavir-221

Erata-434

Edical-D-335

Electrodex-352

Emitab- 1 15

Envit-M-342

Erazole-20

Edicef- 1 7 1

Electro-K-352

Emixef- 1 82

Envitor-62

Erdon super-263 Erdon-253,417

Edifenac-252,253

Electrosal-353

Ernlon-49,57

Eofylin-82

Edimox-48

Elemerol- 1 3 3

Emo-20-20

Epa-20

Ergocalciferol-3 1 9

Edin- 173

Elexime- 1 82

Emodol-391,417

Epalrestat- 143

Ergometrine maleate-405

Ediplex-326

Elical-332

Emollients-293

Epam-5-97

Ergotamine tartrate-245

Ediplex-ZI-3 1 5

Elicin-268

Emonium-9

Epazel-3

Erian-30

Editin-R- 14

Eliclox- 1 6 1

Emov-255

Eperisone-266

Eridon- 1 2

Editrim-205

E-lid-195

E-mox-166

Ephedrine-80,399,423

Eril-40

Edone- 1 2

Elidel-295

Emthexate-366

Ephedrol-276

Erixin- 195

Edopain-255

Elidox- 194

Emycin- 195

Ephidin-80

Erlotinib-389

E-doxy- 1 94

Eliflu-162

Ena-249

Epiclon-1 19

Ermac- 1 95

Edrumycetin-20l ,408

Elimate-284

Enacet-273

Epilep- 1 l 8

Ermite-284

stap kil®

QIMP-15 (509)

iii

Ermox-233

Esopin-20

Eukrim-299

Ero- 195

Esopra-20

Eumovate-287

Erocin-195

Esoral-20

Euphor-l 1 3

Erofen-256

Esotac-20

Euro-196

Erom- 196

Esotid-20

Eusef- 173

Eromac-196

ESP-341

Euthycin- l44

Extravit-plus-3 1 1

Famvir-217

Eromed-196

Espa-8

Euvax-B-382

Extravit-X-330

Fap-238

Eromycin-196,296

Espram-20

Evagren-343

Exuten-102

Fap-plus-240

Erona- 196

Esprazo-20

Evalin-92

Eyebet-41 3 ,428

Fardox-194

Eronix-1969

Estazol-235

Evarin-8

Eyefresh-422

Farevan-65

Erosa- 196

Estilalopram-l08

Evascon-58

Eyemox-4 10

Farmorubicin-363

E-rox- 196

Estriol- 148

Evinol-329

Eyevi-424

Fast plus-240

Errin- 196

Esypan- 1 1 9

Evit-329

Eylon-4 1 5

Fast-238

Ery- 196

Eszopicolne-97

Evo-2 12

Eypro-409

Fastril-40

Erybac-196

E-tab-329

Evocin-212

Eytex-41 5

Fastum-257

Erycin-196

E-tan-43

Evoloxin-2 1 2

Ezeta-7 1

Fat (Fatty acid)-350

Erylin-196

Etform-136

Evonex-21 2

Ezetim-71

Faxilin- 162

Erymex- 196

Etformin- 136

EV-plex-326

Ezetimibe-70

FBC-3 1 1

Erynet- 196

Ethambutol-215

EV-plex-B-326

Ezetrol-71

FCX- 162

Eryped- 196

Ether Anaesthetic-388

EV-plex-M-342

Ezex-287

Fea-238,240

Eryrox-196

Ethro- 196

Exac-14

Ezide- 133

Febrine-444

. . . . j us t kick out

•

. \ .. ' , � Take Q sweet breath by your nose

'

a sweet flower by your hand.

Flucloxacillin

Capsule & Syrup

PAC I F I C

no tension for a11ergy . .

and

< ,

A highly effective b istamlne (H 1 )

B i o c in

C h l o r p h e n i ra m i ne ma leate 4mg tabiet a n d syrup

antagonist used for treatment of any a ller:g1c reaction.�. e

Allergic rhinitis

e

C()mmon cold

e

Urticaria

e

e

It

Sin usitis

fi-Q..

i>-� O .

�vv

1.0 BIOPHARMA

•• _ _ ..... I• • •rw' ••••• lil ••

www.biopharmobd.com

Gen-4- 1 90

Gigacef- 173

Glucolin-352

G-omeprazole- 1 7

G-Vitamin C-328

Genac-253

Gingo-442

Glucomet- 136

Gonal-F- 153

Gyl-228

Genacort-288

Gipid- 134

Glucon-1 3 3

Gored- 133

Gynomix-407

Genacyn-

G-ipra-80

Gluconil- 133

Goserelin-376

Gynoril-407

195,278,409,427

Giran-42

Gluconor-1 34

Goutex-264

G-zinc-339

Genamox- 1 66

Girao-H-52

Glucosal M-353

G-paracetamol-238

G-zol-227

Genaplex-326

G-iron folic acid-309

Glucosamine-360

G-pefloxacine-2 1 4

H.

Genta-409,427

G-iron-306

Glucose saline-353

G-penicillin-V- 160

Gentabac-195,427,429

Gisin-409,428,429

Glucostat-1 33

Gpentin- 1 2 1

Gentamicin-

G-ketamine-388

Glucotin-361

G-pethidine-243

Haemophilus influenzae

194,278,409,427

Glad- 133

Glucozid- 133

G-phase-136

vaccine-379

Gentasol-195

Glamor-422

Glucozon- 139

G-prednisolone- 146

Haemozin TR-3 1 3

Genticin-HC-289

Glaxipro-209

Gludex- 1 46

G-propranolol-35

Haes-steril-355

Gentin- 195,278,409,428

Glemep-1 34

Glunor- 136

GPT-94

Haimozin-TR-486

Gentin-HC-429

G-levamisole-233

Gluphage-XR- 1 36

GQ-2 1 O

Hajmo-A-440

Gento-278,409,428

Glibenclamide- 133

Gluretor- 1 3 8

G-quinine-232

Hajmotab-440

Gento-HC-289,429

Glica-AT- 133

Glustin plus-361

Granisetron- 1 l 6

Halazone-25

Gentosep-278

Glicasil- 133

Glustin-360

G-ranitidine-14

Halcinonide-288

Gentrim-205

Gliclazide- 1 3 3

Glutim-134

Granocyte-377

Halodrop-25

G-ephedrine-80

Gliclid- 1 33

Gluzit- 1 33

G-rifampicin-21 5

Halop- 103

QIMP-15 (513)

Haloperidol-103,127

Hepa-238,240,439

Histacin-268

Halopid- 103

Hepabig-386

Histaco-268

Halosin-389

Hepamilk-439

Histadyl-268

Halotab-25

Heparin-64

Histal-268

Halothane-388,389

Hepatitis-A virus

Histalex-268

Hamdard amla-448

vaccine-38 1

Histalock-268

Humulin- 1 3 1

Hamdard balm-444

Hepatitis-B immune

Histamed-268

Hunny-93

Harndard chyabanprash-

globulin-386

Histanol-268

Hybolin- 1 52

447

Hepatitis-B vaccine-3 8 l

Histaphen-270

Hybucin-7

Harndard honey-447

Hepatolin-439

Histaseem-268

Hydrea-369

Handirub-302

Hepavax-382

Histason-268

Hydrochlorothiazide-45

Hartman-353

Hepavir-22 1

Histatab-268

Hydrocid-3

Hartmann's soln-353

Hepazin-387,439

Histavil-270

Hydrocort-288

Domperidone Tablet & Susp. .

PACI F I C

�

Hysoma-7 Hysomide-7 Hysopan-7 Hyxim-182 Hyzith- 198

Hartman's-354

Heptamin-3 1 1

Histerzin-270

Hydrocortisone-

Hartsol solution-354

Heptaseas-3 2 1

Histin-268,270

146,288,41 6

Havrix-3 8 1

Herceptin-372

Histosin-268

Hydrogenperoxide-304

Hax-330

Herplex-41 3

Hi-tac- 1 4

Hydroquinone-299

H-Ben-235

Hetro-439

Hitagen-268

Hydroxocobalamin-3 1 7

HD-chyabanprash-447

Hexaplex-326

Hitflarn-25 3

Hydroxycarbamide-369

HD-santara-447

Hexiscrub-302

Hi-trol-272

Hydroxychloroquine-263

HD-zainarq-438

Hexisol-302

Hivarif-221

Hydroxyethyl-starch

ESOGlJ l

iii

I. Ibandronic acid-357 Iben-256 Ibuaid-256 Ibuprofen-256 Iburex-256 Ibutab-256 Ichthammol-293 Icid-41 1

' m u lation of g ut motil ity in . . . . .

Dpm'perid(!me. �·Q lTlg

�

N o n - u lcer dyspepsia Reflux esophag itis

�

Gastritis

.... Dia betic gastroporesis o

Prevention & symptomatic relief of acute na usea from a ny cause i nc l u d i ng

cytotoxis

thera py,

radio

therapy & a nti-pa rki nsonism therapy o

In

the

prophylactic

treatment

migra i ne

www.biopharmab

Healer- 1 7

Hexitane-407

HK-20-l 7

(HES)-355

Hectarnox-166

Hiberix-379

Holoxan-362

Hydroxypropyl

Hedex-240

Hi-Cef- l 7 1

Homatropine-41 9

methy1cellulose-426

Helben-233,235

Hi-Clox-1 6 1

Honycol-93

Hydroxyzine-269

Helicon-Kit-24

Hiconcil-166

H-Pen- 1 60

HygiIiol-302

Helmisole-233

Hidin-304

HPR-258

Hylac-7

Hematol-306

Hi-Fenac-25 3

H-Selax-76

Hyoscine butyl bromide-

Hemergin-405

Hiflox-209

H-trimazole-289

7

Hemo plus-3 1 3

Hi-Floxin-209

HTZ-45

Hyosin-7

Hemo-310,314

Hi-Gel-3

Hudson's ORS-35 1

Hypanil-53

Hemobin-306

Hi-Met- 1 3 6

Humaglobin-385

Hypen SR-46

Hemodise-445

Hi-Mox-166,167

Human anti-D

Hypnocum-96

Hemofer-308

Hipa-238

immunoglobulin-386

Hypnofast-96

Hemofol TR-309

Hiposul-326

Human anti-tetanus

Hypotears-423

Hemomin-4l 9

Hipre plus-50

immunoglobulin-386

Hypoten-58

Hemorif-29

Hipre-57

Human chorionic

Hypro-422

Hemosin-68

Hiprex-330

gonadotrophin- 154

Hypromellose-422

Hemostat-69

Hisnul-268

Human normal

Hyronate-361

Hemo-Z- 3 1 3

Hison-146

immunoglobulin-385

Hysin-7

Henxit- 102

Histacet-272

Human-albumin-354,355

Hysocin-7

Icol-408,427 Icrom-4l 8 Icteren-439 Icturn-440 Icykool-247 Idatix-46 Idoxuridine-4l 3 IDS-353 Ifa-TR-3 1 0 Ifel-TR- 3 1 3 Ifen-256 Ifosfamide-362 Ifozin-SR- 3 1 3 Igen-409 I-gold-424 I-guard-408 Ilocin- 196 Ilozin- 198 Iluca-226 Imacep-1 88

of

P ra ZO®20 Omeprazole Capsule

QIMP-1S (S14)

�

Fie

Intrax-69

Isoride-3 53

I-mox-167

Invigen- 195

Isosorbide dinitrate-56

Imycin-193

losol-303

Isosorbide mononitrate-

Ioinix p1us-361

Ipec-307

56

loinix-360

lpec-p1us-314

Isotonic dextrose saline-

lointec-361

Imadol-243

Informet-LA- 136

lpec-super-3 1 5

353

lorix-361

Imatinib-370

Infovir-221

l-penam-192

Isotretinoin-298

lovran- 1 5

Imbac-191

Infucoll hes soln-355

Ipical-333,337

Isotrex-297

IPDrox-3

Imet-257

Infud-282

Ipical-D-336

Isovent-1 6

Iumex-126

Imigra-246

Inhibita-1 7

Ipide-SR-46

Ispaghula husk-24,27

Iunivit-321

Iminem- 1 9 1

Inolac-27

Ipin-58

Ispha-238

I-zinc-339

Irnipen- 1 9 1

Inopil plus-52

Iprarnid-80

Itchin-41 8

K MM-69

Irnipranline-107

Inosit-74

Iprasol-83

Itchin-DS-4 1 8

Immunoglobulin-385

Inositol nicotinate-74

Ipratropium-80,43 1

Itop-3 1 0

Imotil-24

Inoxon-188

Iprex-80

Itra-227

Imovane-97

Inpro- 1 7

Irbes-42

Itracon-227

Kacin- 194

Imped-58

Inran-14

Irbesartan-42

Itraconazole-226

Kadol-243

Impedox- 194

Inseac-14

Iriban-8

Ivactin-283

Kaltide-48

Imuran-372

Insimet- 136

Irigon-401

Iventi-4lO

Kamocillin-I64,165

Inarzine- 1 1 4

Inspra-l02

Irinotecan-370

Ivera 6-236

Kamodrox-3

Inate-339

Instacool-247

Irof-Be-3 1 1

Ivermectin-235,283

Kamornide-230

Iii Offers superior activity over RabeprazoIJ

K.

In the treatment of GERD

� BIOPHARMA

_..... I. ...............

•••

w ww . b i o p h a r m o b d . c o m

Inclox- 163

Insul- 1 3 1

Irofol-309

Indapa-46

Insulatard-1 3 1

Iron dextran-307

Indaparnide-46

Insulin actrapid-1 3 1

Iron sucrose-307

Indapril-52

Insulin insulatard-1 3 1

Iron-Z-TR-3 1 3

Indever-335

Insulin rnixtard- 1 3 1

Iropen- 1 9 1

Indo-A-257

Insulin- 130

Iroplus-3 1 O

Indocap-257

Insuman basal- 1 3 1

Irotrex plus-3 1 5

Indomax-257

Insuman comb- 1 3 1

Irovit-3 1 1

Indomet-257

Insuman rapid- 1 3 I

Irovit-Z-3 1 5

Indomethacin-256,257

Insuman- 1 3 1

lrufen-256

Indomin-257

Intafenac-253,417

ISM-56

Indorex-257

Intafenac-K-255

Isocal-333,336

Indoseem-257

Intal-84

Isocard-56

Indoxyl-257

Intamycin- 195 Intitsone-146,288

Isoclox- 163

Infesen-235 Inflacin-257

Interferon-374

Isofloxin-214

Inflam-256

Intobac-4 1 1

Isoflu- 163,164

Isocontin-56

Influ-223

Intracef- 173

Isoflurane-389

Info-136

Intralipid-350

Isoniazid-215

Informet-136

Intralipos-350

Isonil-9

1. Ianakalyan garlic-440 Ianakalyan jinseng-446 Iasocaine-278,398 Iasocaine-A-398 Iasocal-333 Iasochlor-231 Iasophylin-82

1asoprim-3 3 1 Iasoquin-232 Iasotrim-205 Iasovit-331

Iasovit-M-342 Iedine- 173 Iefril-94 Iemide-447 I-fenac TR-253 Iigarine-440 Iinsant-446

i' •

:..: �-:;

Kamoxy- 1 67 Kanaprim-231 Kanaquine-232 Kanis-28 1 ,428 Kapron-209 Karvedil-37 Kdrine- 127 Kefdrin-173 Kefen-269 Keflll1- 1 82 Keflin- l 7 1 Kefosed-94 Kefrad-173 Kelac-391 Kemadrin-127 Kemet-228 Kernin- 136 Kenacol- 147 Kenacort-A-147 Kenodol-391

QIMP-IS (SIS)

Keolax- l 00

Kids-B-339

Labecard-38

Keor- 182

Kilbac-179

Labeta-38

Keplex- l 7 1

Kilmax-179

Labetalol-37

Keptrix- 188

Kilpro-228

Lacicard-59

Kerolac-39 1,417

Kitex-25 1

Lacidipine-58

Ketalar-388

Klaricid-200

Lacitone-48

Lardon-TR-253

Ketamine-387,388

Klion-229

Lac1ose-28

Larnox-82

Keteks-391

Knock-238,240

Lactab-332

Lastet-367

Ketifen-83

Kofed-94

Lactameal-3

Latanoprost-422

Keto-A-257

Kofen-84

Lacticare-293

Laten-99

Ketobe-391

Koftex-91 ,94

Lactitol-27

Lax-28

Ketocon-227

Koloride-353

Lactogen-348

Laxate-27

Ketoconazole-

Kolosal-353

Lactolax-28

Laxative-28

227,282,301

Konakion-69

Lactoride-354

Laxenna-27

Ketodil-84

K-one-69

Lactu-28

Laxitol-27

Ketof-84,417

Kontab-267

Lactulose-27

Laxol-28

Ketoflex-391

Kontrol-257

Lactulose-H-28

Laxolac-28

Ketofun-227

Kop-257,258

Lafrost-280

Laxonil-99

Ketomar-84,417

Koptolin-76

Lamictal- 1 2 1

Laxur-48

Ketonac-257

Koreg-37

Lamidin-221

Laxyl-99

Ketonic-391

Kotron-251

Lamisil-227

Lazo-21

levocetirizine Dihydrochloride Tablet

ii

PACI F I C

Leoflox-212 Leo-rubbing-248 Lepath-179 Lepsone-216 Leptic- 1 l 9 Lequin-2 1 2 Lercanidipine-58 Lerex-274 Lerozol-375 Lesal-78 Lescol-73 Lesterol-73 Letab-2 1 2 Lethiquin-21 2 Letrol-375 Letrozole-375

•••_...... ... .. , •••• ••••1 •• ww w . b i o p h o r m O b d . c o m

Ketoprofen-257

K-pol-240

Lamitrin- 1 2 1

L-carni-62

Ketoral-227

Krimina-233

Lamivir-221

Leanxit-102

Ketorin-391

Krimizole-235

Lamivudine-220

Lebac-174

Ketorolac-39 1 ,417

KT-352

Lamotrigine- 1 2 1

Lebrod-78

Keto-SR-257

K-Trim-205

Lanoxin-33

Lecet-274

Ketotif-84

Kufflin-92

Lanozole-21

Lecetrin-274

Ketotifen-84,417

Kulzam-444

Lansec-21

Lecitin-274

Ketromin-391

Kumucin-196

Lansina-21

Lee-212

Ketron SR-257

Kuracef- 182

Lanso-21

Leecain-398

Ketron-257

Kvit gold-346

Lansodin-21

Leevotin-212

Kevil-274

Kvit-B-326

Lansoprazole-20

Lefex-212

Kevilon-302

Kvit-C-328

Lansoprol-21

Leflox-212

Kevirub-302

Kvit-E-329

Lantid-21

Leflunomide-263

Kezid- 133

Kvit-M-331 ,342

Lantus-132

Lefoam-6

Kflam-391

Kvit-N-323

Lanzol-21

Lekopil-99

Khabar saline-351

Kvit-TH-321

Lap-21

Lemon-C-328

Khamira Gaozaban

Kynol TR-258

Lara-275

Lemovit-C-328

Amberi -391

Kynol-25 1

Larb plus-53

Lenit-62

Larb-43

Lenograstim-377

Larcadip-58

Leo-2 1 2

Kiddi-321 Kidovit-331

L.

Leucoder-226 Leucomin-448 Leukeran-362 Levair-78 Levamin-233 Levamisole-233 Levamisole-M-233 Levatrax-233 Leventa-78 Levetiracetam-434 Levin-212 Levobac-212,41O Levocar-62 Levocarnitine-62 Levocet-274 Levocetirizine-273 Levocin-2 1 2 Levocos-21 2 Levodopa-125 Levoflox-212,41O

QIMP-15 (516)

PACIFIC

Lirel-67,68

Lomebac-41O

Lorin-274

Liset-274

Lomecin-4I O,428

Lorix-284 Losa-43

Lisinopril-40

Lomeflox-21 3,41O

Lispril-40

Lomefloxacin-

Losacard-43

Lister cool mint-435

2 1 3,410,428

Losacard-HZ-53 Losacor plus-53

Levofloxacin-21 1 ,409

Licef- l 7 1

Lit-129

Lomeqiun-41O

Levogen-212

Licerin-284

Lite-27

Lomesec-1 7

Losacor-43

Levoking-2 1 2

Lidocaine-398

Lithium- 106

Lomosis-438

Losan-43

Levolex-212

Lifcin-212

Lithosun- 1 06

Lonazep- 1 1 9

Losan-D-53

Levolon-212

Life gold-346

Litizem-58

Lonet-35

Losanil-43

Levomet-212

Life silver-347

Litrim-205

Lopadine-41 8

Losap-43

Levonix-212

Lignocaine-32,278,398

Livacin-212,410

Lopadol-391,417

Losar-43

Levonorgestrel- 159

Limaryl-134

Livas-72

Lopamid-24

Losarcar-43

Levoquin-212

Limep-134

Livax-28

Lopan-7

Losarcar-plus-53

Levora-212

Limerid-135

Liverton-28

Loperamide-24

Losardil-43

Levorex-274

Limpet-135

Livial-156

Loperdium-24

Losardil-plus-53,54

Levosalbutamol-77

Limus-295

Livita- 3 1 5

Loperin-24

Losart-43

Levoseem-2 1 2

Lin-2 1 2

Livocard-67,68

Lopez- l04

Losartan HZ-54

Levosina-212,41O

Lindac-261

Livodel-78

Lopin-58

Losartan potassium-42

Levosol-233

Lindex-174

Livodon-2 1 3

Levostar-78

Lind-S-405

Livoton-28

Levostin-21 2

Linez-202

Levox-2 1 2

Linezolid-202

Levoxin-212,41O

. Lopirel-67,68

Losart-plus-54 .

Loplet plus-68

Losatan-43

Lizen-202

Lopo-43

Losectil-17

LK plus-53

Lopos plus-53

Losek- 17

Lingin-274

LK-43

Lopos-43

Losita- l08

Lexa-2 1 2

Linoril-40

Locard-58

Lopres-35

Losium-43

Lexaton-396

Lioresal-266

Locin-2 13

Lopresor-38

Lospil plus-54

Lexazen-2 1 2

Lipex-72

Locol�72

Lora-274,276

Lospil-43

Lexil-99

Lipicon-72

Locopain-253,417

Loracef- l77

Lospre-43

Lexipen-170

Lipicut-72

Loctoz-28

Loracil-274

Lostan-43

Lexlo-2 1 2

Lipidof-71

Locular-421

Lorades-275

Losucon-1 35

Lexotanil-99

Lipigent-72

Lodicard-50

Loradin-274

Lotas-43,54

Libidex-442

Lipinor-72

Lodin-274

Loramide-24

Lotensin-421

Libonex-443

Lipired-71

Lodipin-58

Lorapam- loo

Lotensyl-58

Libotil-179

Lipitin-72

Lodoxamide-4 1 7

Lorat-274

Lotrix-284

Libott-352

Liplo-72

Lofat-71

Loratadine-274

Loval- 1 2

Libott-M-353

Lipobi-72

Lofens-249

Loratec-274

Lovastatin-73

Libott-S-352,353

Lipril-40

Loflox-41O

Loratin-274,276

Lovatin-73

Libracin-209

Liptor-72

Logat-21O

Lorazepam-loo

Loverin-7

Libradin- 174

Liqu-E-329

Lok plus-54

Loren-274

Lovicin-2 1 3,41O

Librazol-229

Liquical-320

Lok-43

Lorfast-274

Lox-209

Libret- 1 5

Liquid paraffin-28

Lolly gold-346

Loridon- 1 2

Loxim- 1 8 2

R a c a rd .® 1.25, 2.5 5 ii

QIMP-15 (517)

Loxin-21 3

Macin-196

Maullaham-446

Loxyl-167

Maclar-200

Mave-8

Lozana- 158

Maclo-249

Maxbac- 1 86

Lozicum- l 00

Maclon-3 17

Maxcef- 1 84

&

Ramipril Tablets

PAC I F I C

Lozide- 134

Macro-196

Maxflo-U-403

LQ-500-2 1 3

Macrobid-200

Maxical-336

Mecomin-3 1 8

Megatrim-205

Ltdin-274

Macrocin-T-296

Maxical-337

Mecopen- 3 1 8

Megatrol-274

Luban-DS-235

Macrozith- 198

Maxiflox-41O

Mecozol-229

Megion- 188

Lubric-422

Maczith- 198

Maxil- 1 l 6

Mec-P- 1 l 5

Meglu- 136

Lucan-R-226

Magadrate-3

Maxima-20

Med-cal-333

Melagyl-229

Lucentis-425

Magadrox-3

Maxitrol-415

Medibion-323

Melatil- 1 l 5

Lucetam- 127

Magaplus-3

Maxocol- 1 l 6

Medicef- 174

MeJcam-259

Lucidol-243

Magmil-5

Maxpro-20

Medifen-353

Mele-448

Lucon-220

Magnason-5

Maxrin-403

Medinahl-304

Melev- l l l

Ludiomil- 107

Magnesium hydroxide-5

Maxsulin-1 3 1 , 1 32

Mediphakol-425

Meliva- 109

Luf- l 64

Magnesium salt-338

Mazic-339

Medirex-233

Melixol-l02

Lugol's iodine- 1 45

Magnogel-3

Mazith- 198

Meditrim-205

Meloxicam-258

Lumeran- 1 5

Magsum-338

MB-12-3 1 8

Medivit-326

Melphalan-362

Lumertam-232

Makcin-196

Mbroxol-92

Medivit-M-342

Melphin-235

Lumex-410,428

Malaeide-232

M-card-58

Medix-444

Meltix-103

Lumisec-17

Malason-232

M-Dazole-229

Medizol-229

Memopil-127

Lumona-85

Malex-232

Measles vaccine-382

Medrol-147

Memorin- 129

Lupid-440

Malfan-232

Mebalon-279

Medrolin-270

Menaril- 1 l 6

Lupron-274

Malinate-233

Mebantrin-233

Medroxyprogesterone-

Menat- 179

Luretic-47

Malodoxin-232

Mebel-DS-235

151

Mencevax-382

Lurex-94

Maltovit-3 1 5

Mebendazole-233

Mefa-258

Menilet-229

Lutisone-288,433

Manil-8

Mebendol-233

Mefalgin-258

Meningococal vaccine-

Lyflox-4 1 O,428

Manisol-49

Mebeverine-8

Mefenamic acid-258

382

Lynes- 158

Mannitol-49

Mebhydrolin-270

Meflon-23 1

Meningococcal (A+C)

Lynestrenol-150

Mapez-99

Mebidal-270

Mefloquine-23 1

vaccine-382

Lysovita-326

Maprocin-209

Mebolin-270

Mefoglip-142

Mennitol-49

Lysovita-B-326

Maprotiline- l07

Mebrex-233

Meforex-136

Menocare-448

Lytex-92

Marbelus-438

Mec lixin-1 l5

Meforin- 136

Menol-229

Mardox-194

Mecetra-268 Meclid� 1 1 6

Mefrad- 174

Menorest- 157

Maret-281

Mega-C-328

Menotox-448

Marlox-3

Meclizine- 1 l4

Mega-cef- 174

Menthol-95

Marvelon- 158 Maso-360,361

Mecobal-3 1 8

Megacin- 174

Mepid- 135

Mac - l 96

Mecobalamin-3 1 7

Megadox- 1 94

Mepra- 17

Macas-196

Mastel-276

Mecol- 3 1 8

Megafen-253

Meradexon- 146,4 l 4,429

Macazi- 198

Mastguard-41 8

Mecolagin-3 1 8

Mega-Flox-21 4

Mercaptopurine-366

Macery-196

Masturin-448

Mecolin- 3 1 8

Megaset-205

Merin- 1 2

M. Mabthera-373

H i p re® p l u s iii Amlodipine + Atenolol Tablet

'

PACI F I C

QIMP-IS (518)

Mexilyt-92

Minolac-391

Monamox- 167

Mexlo-213,410

Minomal-R-82

Monamycin-278

Mextil- 179

Miovit-323

Monas-85

Mez-229

Mirolast-4 1 8

Monate-56

Mezal-229

Mirtaz- 1 l 2

Monipro-209

Merison- 1 l6

Methotrexate-366

Miacalcic-356

Mirtazapine- 1 1 2

Merobac- l 92

Monipro-209

Methotrin-205

Mic-28 1

Misc. Names

Merocef- 179

Moniten-56

Methovate-30,285

Mic-HC-289

Misoclo-263

Monitol- 1 l 3

Merom- l 92

Methovate-N-286

Mici-H-290

Misofen-263

Monocard-56

Meropen-192

Methoxsalen-292,300

Miclo-287

Misoprostol- 1 6

Monocast-85

Meropenem- 1 9 1

Methyl cellulose-24,27

Miclocin- 1 6 1

Mitargan-270

Monopril-40

Mervan-249

Methyldopa-34

Miclofen-253

Mithin-284

Monosol-283

Mesacol-26

Methylprednisolone- 147

Miclofenac-263

Mitomycin-364

Monosprin-66

Mesalazine-26

Metiglit- 143

Micoderm-281

Mitomycin-C-364

Monosulfiram-283

Mesna-363

Metin- 136

Micogyl-229

Mitosan plus-54

Monotrate-56

Mespa-8

Metmin- 136

Miconazole-227,281

Mitosan-44

Monovit-341

Met- 136

Metocard-38

Miconex-281

Mitrazin- 1 l 2

Monprox-85

Meta plus TR-310

Metocloprarnide- 1 3 , 1 1 6

Miconil-289

Mitrocin- 196

Montair-85

Metacard-60

Metocol- 1 l 6

Micoplex-B-326

Mixavil-321

Montelukast-84

Metadaxan-414,429

Metoniol-229

Micoplex-M-342

Mixit- l03

Montene-85

Metaloc-38

Metopa-142

Micoral-227,281

Mixtard- 132

Moodon- 1 l 3

Rontro' of all forms of eczema even i n yOunlll:CI�mll'i •

Certain forms of psoriasis

•

Severe acute photosensitivity

•

Acute contact dermatitis

•

Idiopathic pruritus of the arlo!�enI1�al.

•

Lichen planus

•

Localized bollous disorders

•

Keloid scarring

•

Pretibial myxedema

•

Vitiligo

•

Lichen simplex chronicus

•

Atopic dermatitis

•

Stasis dermatitis •••• ,"." I • ••' '''!�',!,;'''�,' .''�•. www . b i o p h

Metarin- 136, I 43

Metoprolol-38

Micosone-290

Mizol-281

Metason-229

Metoxim- 1 85

Micovit-33 1

Mizolam-96

Moriarnin-M-3 1 1

Metazid-142

Metra-229

Micozol-28 1

Mizolastine-275

Morphine-242

Metco-229

Metrim-205

Micozol-HC-290

M-kast-85

Morphinex-242

Metfar- 136

Metrion-229

Micturex-46

MMR vaccine-382

Morvilvax-382

Moov-253,255

Metfast-ER- 136

Metrizol-229

Midazolam-96

Mobifen-253,417

Moset-272

Metfen- 136

Metro-229

Midopril-S2

Moci- 167

Motidom- 1 2

Metfil-229

Metrocin-257

M�io1en-245

Modecate- I O 1

Motifast- 1 2

Metfo XR- 136

Metrogyl-229

Migranil-245

Modipran- l l 0

Motifen-249

Metfo- 136

Metromax-229

Migrin-245

Mokast-85

Motigen- 1 2

Metform-136

Metronidazole-227

Migriz-244

Molus-85

Motigut- 12

Metformin- 1 35

Metropill-229

Milam-96

Momcap-3 1 1

Motil- 1 2

Metglip- 142

Metrosil-229

Milk o f magnesia-S,28

Momento-275

Motilant- 1 2

Methacin-257

Metroson-229

Millat malam-292

Momeson-433

Motilex- 12

Methasol-4 13,428

Metrozen-229

Millat oral saline-3 5 1

Mometa-290

Motilon- 1 l 6

Methasol-N-41 3 ,428

Metryl-229

Minia-84

Mometasone-290,433

Metherspan-405

Motiper- 12

Metsina-229

Minifor-136

Momvit-347

Motoral-264

Methicol-3 1 8

Meverin-8

Minipril-40

Monaclox-F- I64

Motrim-205

Methocid-257

Mexiderm-285

Minium-246

Monacom-290

Methotrax-366

Movex-249

Mexiderm-N-286

Minocap-68

Monadox- 194

Movlan- 1 l 6

Hipre®

QIMP-15 (519)

5 & 10

Movon-249

Multisina-347

Myocal-333

Mox- 167

Multitonic-345

Myodon- 1 2

Moxa- 167

Multivin-33 1

Myolax-396

Moxacil- 167

Multivita-342

Myolin-323

Moxac1av-169,170

Multivitamin-3 3 1

Myonil-266

Moxapen- 1 67

Multivit-plus-342

Myrox-92

Napium-259

Naxo-260

Moxatid- 167

Mulyt-92

Mystacin-272

Napix-259

Naz-41 2

Moxibac-410

Mumox-167

Mystatin-225

Napren-259

Nazin-41 9

Moxico- 167

Mumpsvax-382

Mystin-R-15

Napro-259

Nazolin-43 1

Moxiflox-2 1 3

Munil-92

Mystocal-333

Napro-A-259

Nebacin-279

Moxifloxacin-213,410

Mupi-279

Mystrum gold-346

Naproben-259

Nebactil-400

Moxilin-167

MupirQcin-278

M-zed-229

Naprocid-259

Nebanol-279

Moxin- 167

Muroderm-279

Naproson-259

Nebium-lOO

Mox-plus-167

Muron-279

Naprosyn-259

Nebivolol-38

Moxquin-41 0

Musc1ex-396

Naprox-259

Nectar-93

M-plex-326

Musis-93

Nacid-14

Naproxen-259

Neeper-284

M-pol-238

Musol-93

Nacromin-41 8 ,432

Naproxin-259

Nefopam-241

M-Trim-205

Mutac-15

Naf-225

Napryn-259

Neforex-241

MTX-366

Mute-92

Naid-242

Napsod-259

Negaron- 1 1 4

Mubrox-92

Muterol-79

Nalbun-242

Naptodin-259

Nelagyl-229

Mucaryl-92

M-vit-331

Nalepsin-338

Nasida-253

Nelfinavir-21 9

Amlodipine Tablets

N_

Lo po

o

Losartan Potassium 50 mg & Hydrochlorothiazide 12_5 mg

Significantly reduces the systolic & diastolic BP

o

More effective than monotherapy

o

An ideal therapeutic option in severe hypertension

o Less adverse effects than angiotensin receptor

blocker alone

... an ideal combination to fight against hypertension

ii

PACI F I C

o Smoothly controls BPfor 24 hrs with once

daily dosing

o Less expensive than multiple therapy

Ie BIOPHARMA

Committed to Serving Mankind

Mucobrox-92

Mycef-174

Nalid-400

Nasochrom-41 8,432

Nelod-58

Mucof-92

Mycin-197

Nalidex-400

Nasox-259

Nelvir-21 9

Mucogel-3

Mycocin-225

Nalidixic acid-400

Naspro-259

Nematox-235

Mucola-92

Mycoder-226

Nalidixin-400

Natacin-41 1

Nenol-279

Mucolex-93

Mycofin-227

Naligram-400

Natadrop-41 1

Neo-B-279

Mucolyt-92

Mycofin-282

Nalitrum-400

Natamycin-41 1

Neobac-4 1 2

Muconil-92

Mycon-281

Naloxone-95

Natavit-3 1 1

Neobacin-279

Mucopront-93

Mycorest-226

Nalphin-242

Nateglinide- 137

Neobacrin-279

Mucosol-92

Mydocalm-396

Naltrax- 130

Natoph-41 1

Neobet-286

Mucospel-92

Mydox- 194

Naltrexone- 1 29, 130

Natrilix-46

Neobet-E-413

Mucut-92

Mydrimide plus-420

Narnicin-2 13,410

Natri-SR-46

Neobion-323

Mudibak- 1 13

Mydrimide-41 9

Nan-348

Naunehal-438

Neocal D-336

Multi gold-346

Mydripine-6

Nandrolone- 1 5 2

Naurif- 1 17

Neocal-333

Multi-7-3 3 I

Myelin-323

Napa Extra-240

Navacef-177

Neoceptin-R- 1 5

Multical-337

Myfortic-373

Napa-238

Navac1ox-1 6 1

Neocilor-275

Multicef- 174

Mylac-28

Napasin-259

Navalexin- 1 7 1

Neocin-279

Multifol-3 1 1

Myleran-362

Napec-259

Navamox-167

Neocitrin-279

Multi-M-342

Mylovit-3 1 1

Napguard-293

Navatrim-205

Neocort-286

Multiseas-321

Mylovit-Z-3 1 6

Naphalon-41 9

Naxcel-93

Neodin- 1 5

Multisina-3 3 1

Mymoxcil- 167

Naphcon-A-41 9

Naxin-260

Neo-DP-41 5

Fenorat® Fenofibrate Capsule

QIMP.15 (520)

=

PACI F I C

Nexum-20

Nitazoxanide-24

Norad plus-343

Ngcef- l S2

Nitoxin-25

Norad-330

NGS-41 5

Nitrazepam-96

Norbit-32

N-hexin-93

Nitrin-SR-56

Norcolut- 1 5 1

Niazid-25

Nitrocap la-56

Norcuron-395

Neodrop-6

Neosuxa-395

Nicin-4 1 1

Nitrocard-56

Neofenac-253

Norditropin- 155

Neotack- 1 5

Niclosamide-235

Nitrodil-56

Nordrin-SO

Neofexim- 182

Neotid- 1 5

Nicorandil-60

Nitrofurantion-400

Nordrine-399

Neofix-182

Neotigason-292

Nicosit-74

Nitromint-56

Norethisterone- 1 5 1

Neoflam-256

Neotin- 1 5

Nicoson-322

Nitronal-56

Norex-330

Neoflox-209

Neotracin-280

Nicotinic acid-B3-322

Nitrosol-56

Norfen-253

Neofloxin-209

Neotrax-233

Nid-339

Nitro-SR-56

Norfluc 1 1 3

Neogen-280

Neotrim-205

Nida-229

Nitrovas SR-56

Norium-246

Neogyl-229

Neovit-3 2 1

Nidazyl-229

Nivoloc-21 3

Noriz-272

Neokit-24

Neoxit- 103

Nidipine-59

NixaIo-99

Normacid- 1 5

Neolev-2 1 3

Neozith- 198

Nidipro-50

Nizoder-301

Norma-H-15 Normal saline-353

Neolor-275

Neptor-20

Nidocard-56

Nizoral-282

Neonate-82

Nerva-323

Nifecap-59

N-mycin-4 1 1

Normalin-353

Neopanta-2 1

Nervex-3 1 8

Nifedipine-59

Noak-249

Normanal-29

Neopara plus-240

Nervin-322

Nifin-59

Noanxit- lOO

Normasol-353

Neopara-238

Nervo-B-323

Nifura-2S0

Nobac-214

Normaten-35

R-pil Ra m i p ri l B P

o

o

o o

Opens the way to

hope for

In cardiovascular riskprevention In acute myocardial infarction

In modifying the natural history ofatherosclerosis In patients with renal dysfunction

I� BIOPHARMA

In patients with diabetes mellitus

Committed to Serving Mankind

Neopep- 1 5

Netilmicin- 195

Nightus-99

Nobesit- 136

Neopra- 17

Neubin-323

Nikethamide-95

Nobum- 1 2

Normens- 1 5 1

Neopril-40

Neupogen-377

Nilac-297

Nocid-4

Normogut- 1 2

Neoprox-185

Neural-3 1 8

Nilkof-91

Noclog-67,68

Norpress-35

NeoraI-295,373

Neuralgin-323

Nimocal-59

Nocon-43 1

Norry-99

Neorex- 1 7 1

Neurex-B-323

Nimodi-59

Noctin-97

Norsol-427

Neorice-352

Neuro-B-223

Nimodipine-59

Nodepress- 1 1 0

Nortin- 107

Neorofen-256

Neurobest-223

Nine seas-321

Nodia-264

Nortriptyline- l 07

Neosaline-35 1

Neurolep- 127

Nintoin-400

Nofenac-249

Norvent-8 1

Normatensin-440

Neoset-205

Neuropen- 1 2 1

Nipa-238

Nofiate-7 1

Norvis-9

Neosetin-R- 1 5

Neurotin- 1 2 1

Nipaped-74

Nokof-93

Norzin- 1 1 3

Neosol-352

Neurovit-3 2 1

Nipaplex-326

Noler-272

Noscab-284

Neosol-DS-352

NeutraI-3,4

Nipavit-3 3 1

Nomi-245

Nosemin-272

Neospectra-2 1 4

NeuvitaJ-323

Nipavit-M-342

Nomigran-244

Noseral-284

Neospin-66

Newage-344

Nishat-423

Nomopil- 1 3 8

No-Spa-8

Neosten-281 ,406

Nexcap-'20 .

Nispore-226

Nomosic- 1 14

Nostis-361

Neosten-HC-289

Nexcital- 1 09

Nitanid-25

Nomotil-24

Nostrin-249

Neostig-397

Nexe-20

Nitax-25

Nooze-260

Notens-99

Neostigmine Rotex-397

Nexito- 109

Nitaxide-25

Nop-40

Notrol-272

Neostigmine-265,396,397

Nexpro-20

Nitazox-25

Nopain-255,417

Nova-238,240

QIMP-15 (521)

iii

Omex- 1 8

Novadin-174

Ocin-405

Novarin-253

OcIazid- 134

Omezole- 1 8

Novastin-74

Octabid-209

Omid- 1 2

Novatac-17

Octon-97

Omidex- 1 8

Novin-43 1

Octreotide-376

Omidon-12

Novirax-280

Octrim-205

Omiloc- 1 8

Opticol-D-414

Orioplex-326

Novirex-136

Ocudex-429

Omirex- 1 8

Optiflox-410

Orioplex-M-352

Novo ors saline-351

Ocugel-425

Omitac- 1 8

Optimox-41 1

Orixyl- 167

Novo zinc-339

Oculear-422

Omitin- 1 8

Optimycin-195

Orket-258

Novocaine-427

Ocumox-410

Omizit- 1 8

Optipan-418

Orlev-209,213

Novomix-132

Ocupres-421

Omnic1ox- 1 6 1

Optison-N-41 3 ,428

Orlistat- 128

Noworm-235

Ocusol-4 l 6

Omniflox-2l 4

Optiven-79

Ormet-230 Ormin- 136

" Folic Acid + Zinc Sulphate Tablet

PAC I F I C

Nox-330

Ocuvit-424

Omnimycin- 193

Opton-20

Noxid-330

Odacef-1 82

Omnitrop lica- 155

Optophenicol-427

Omid-230

NPG-94

Odaz- 198

Omnivit-3 l 6

Or-230

Omidazole-230

NPH-4l 6 ,429

Odazyth- 198

Ompa-1 8

Orabex-326

Omil-230

NSB-280

Odmon-85

Omrazol- 1 8

Oracal-333

Omizol-230

Nt-par-235

Odrel-67,68

Omsec- 1 8

Oracal-M-337

Omys-225

Nuba-280

Oestrogen-147

Omtric - 1 8

Oracyn.K-160

Orogel-246

Nufex- l 7 1

Ofcof-91

Onaseron- 1 l 8

Oradexon-146

Orpa-238

Nugesic-323

Ofex- 182

Oncodex-1 1 8

Oradin plus-276

ORS Saline-351

Nuprafen-260

Oflacin-2 14

Ondansetron- 1 17

Oradin-274

ORS-35 1

Nuprin-284

Ofloxacin-213,4 1 1 ,428

One Alpha-320

Oradol-3 9 1 ,417

ORS-A-35 I

Nurobix-322,323

Ofpain-39I

Oni-286

Oraf-226

Orsal-76

Nutriace-3 30

Ogli-139

Onicon-226

Orafen-SR-253

Orsaline fruity-351

Nutridex-352

Oilatum-293

Onida-229

Orill Rehydration Salt

Orsaline-351

Nutrisaline-352

0-Lac-348

Onium-9

(ORS)-350

ORS-Brack saline-35 1

Nutrisol-s-349

Olanap- l 04

Onsat- 1 1 8

Oral saline-351

ORS-N-35 1

Nutrivit-B-326

Olanzapine-1 04

Ontin-272

Oral virelon-383

ORS-ORS-351

Nutrivit-C-328

Olcin-2 1 3

OP-20- 1 8

Oralax-28

ORS-Rena saline-35 1

Nutrivit-E-329

Oleanz- 104

Opal-1 8

Oralon-302

Ortac- 1 5

Nutrivit-MV-331

Olif-226

Opazol- 1 8

Oral-Z-339

Orthocal D-336

Nutrovita-326

Olmesartan-43

Opdex-41 5,429

Oral-ZB-341

Orthocal-333

Nutrum 50+-345

01odin-41 8

Open- l60

Oralzin-339

Orva-72

Nutrum bone-337

Olopatadine-41 8

Opezen- 1 8

Orarnet plus-143

Orvatin-72

Nutrum gold-340

0lpadin-41 8

Opidol-243

Oramet- 136

Oryx- 188

Nutrum junior-345

Omag- 17

Opifen-393

Oramycin- 193

Osartan-54

Nutrum PN-344

Omalizumab-90

Opra-1 8

Orange-C-328

Osartan-HZ-54

Nutrum super-343

Omaprin-17

Opsocrom-41 8 ,432

Orasol saline-351

Osartek-43

N-vit.324

Omastin-226.

Opsomycetin-201

Orazid- 134

Osartil-43

NVmet- 136

Om-capsule- 17

Opsonil-l 0 1

Orazinc-3 15,339

Osartil-50 plus-54

Nyclobate-287

Ome- l 7

Opsophenicol-408,427

Orbalin- 1 6 1

Oscal-333,337

Nyc1obate-NN-288

Omeben- 1 8

Opso-Rinse-427

Orbidex C-414

Oscal-D-336

Nyolol-421

Omecap-17

Opsovit-3 1 5 ,326

Orbidex T-4 1 5

Osecton- 1 8

Nyst-225

Omeflox-41 0

Opsovit-MM-342

Orbidex-414

Oseflu-224

Nystat-225

Omegut- 1 8

Optabac-408

ORC-392

Oseltarnivir-223

Nystatin-224,28 1

Omel-1 8

Optacarpine-42I

Orcef- I S2

Osetron- l l S

Omenix- 1 S

Optacrom-418,432

Orfenac-253

Osmin-D-336

Omenta-I S

Optadex-414

Orfix- IS2

Osmolax-2S

Omep- I S

Optagel-425

Orgarnetril- 1 5 1

Osmosol-49

o Saline-35 l

0_

Omepra-I S

Optaloc-420

Orgatril- 1 5 1

Ossi-333,336

0-20- 1 7

Omeprazole- 1 6, I S

Optaphenicol-40S

Orgy-272

Ostacid-333

0-40- 17

Omeprol- 1 S

Optavit-41 1

Oricef- I S S

Ostacid-D-336

Obenil-128

Omesil- 1 8

Optl).acol-40S

Oricox-256

Ostan-43

Obid- 1 36

Omet- 1 S

Opthaflox-410

Orifen-249

Ostel-357

OC-20- 17

Ometac- l S

Optichlor-40S

Orin-274

Ostel-D-359

Ocamix-62

Ometid- I S

Opticol-40S

Oriodox- 1 94

Osteo-D-319

Neorice® Rice Used ORS

To get rid of the edverll eHectl of dllrrhoel

� " IThYr;{( O.guw� � .

" ®

Glucose based reduced osmolarity oral saline

Fexodin® Fexofenadine Tablet

QIMP-15 (522)

ii

PACI F I C Ostiferol-D-336 Ostirn-334 Ostocal-334 Ostocal-D-336 Ostocal-JR-334 Ostocal-M-337 Ostocin-247 Ostocurb-334 Ostoflex-349 Ostogen plus-337 Ostogen-334,336 Ostomax-357 Ostoplus D-336 Ostoplus-334 Osyn-18 OticIor- 177

Oxecylin- 193 Oxetin- l l0 Oxetol-122 Oxforte-330 Oxicam-261 Oxid-330 Oxifyl-62 Oxilar-360 Oxitab-330 Oxivit-330 Oxpentifylline-62 Oxsoralen-292,300,301 Oxybutynin-402 Oxycaine-427 Oxymetazoline-431 Oxyphenonium bromide-

Pain zero-253

Pantosil-22

Pedicin- 197

Painex-249

Pantozol-22

Pedicon-6

Painil plus-240

Pantro1-20-22

Pedilar-269

Painil-238

Panvit-331

Pedilid-200

Pair-392

Panzol-22

Pedisol-353,416

Pairox-260

Para-238

Pedi-Z-339

Palcef- 180

Para-C-238,240

Pedox-194

Pamel-20-22

Para-caf-240

Peegee-139

Pamox-l64

Paracet plus-246

Pefla-21 4

Pamoxil- 167,168

Paracetamol-237,238

Peflacine-214

Pana-238

Paracin-240

Peflam-256

Panadol-240

Parafen-238

Peflon-214

Panalon-394

Paramol-238

Peflox-214

Panamox-333,234

Parapyrol-238

Pefloxacine- 195

Pancipro-109

Paraxia-238

Peginterferon alfa-222

Pancreatin-30

Paraxia-plus-240

Peg-intron-222

Pancrestal-30

Parcef-188

Peldol-J03

Pancuronium bromide-

parflox-214

Pem-339

394

Paricel-23

Pemast-4 1 8

Pancuronium-394

Paridoil- 1 2

Pemirolast-418

Pandeflu-224

Parillex-9

Pen-A-16S

The 1st & only bioequivalent Omeprazole brand in Bangladesh ,.••

The rightly formulated pantoprazole tablet

.. ARISTOPHARMA LTD_

Otonix-21 Oto-Plus-427 Otosil-270 Otosporin-429 Ovel-2 13,410 Ovestin- 148 Ovidrel-154 Ovit-A-3 i 9 Ovit-E-329 Ovostat-158 Ovuclon- 153 Ovulet- 153 Oxacin- 193 Oxaliplatin-370 Oxapro- l09 Oxaprozin-260 Oxat-20- 1 1 1 Oxazep- 121 Oxcarbazepine-121 Oxecone-4

M Ulufa(turPf of Ph,Hll1dU'Utl(.I1 PrurilKh

8,419 OxytetracycIine-193,428 Oxytocin-405 Oz-20-1 8 Ozole- 1 8

P. P+C-240 P-20-21 P-40-22 Paba-205 Pac-240 Pace-240 Pacet-32 Pacibion-324 Pacin-V- 160 PacIitaxel-371 Pactorin-56 Paichish-438

, , "1 � .../ "I

'r,

Panfre SR-253

Parinox-65

Penac-253

Panodin SR-255

Parlox-214

Penacin K-160

Panoral-22

Paroxet- 1 1 1

Penalox-198

Panprazo-22

Paroxeline- l 10

Penarnin-268

Panpro-22

Parten-43

Pencin- l 60

Pansec-22

Partobulin-386

Penci-V-160

Pantac-22

Pase- 1 1 9

PencIox-161

Pantaloc-22

Patadin-4 18

Pendol-243

Pantalok-22

Patalon-41 8

Pendoril-40

Pantex-22

Pavisia-290

Pendoril-plus-52

Pantid-22

Pax-240

Penflu- l 64

Panto-22

P-cef-174

Penicillin-G- 160

Pantobex-22

P-cool-247

Penicillin-V-160

Pantodac-22

P-don-12

Penrif-247

Pantogen-22

Pectoral-441

Pentab-160

Pantogut-22

Pedearnin-269

Pentaglobin-385

Pantonix-22

Pedial-318

Pentaxim-380

Pantopra-22

Pediasure-349

Pentolin-62

Pantoprazole-2 1

Pediavit-321

Pentyl-388

Pantosec-22

Pedicef- 185

Penvik- 160, 161

QIMP-lS (S23)

Pime- 190

Penxit- l03

Petracin-278

Peocal D-336

Peuritar-26

Pimecrolimus-295

Peocal-334

Pevaryl-281

Pinam- 170

Peoflox-209

Pevicort-290

Pinor- 107

Peoplex-326

Pevisone-290

Piocin-214

Pep-339,340

Pevitin-290

Piodar- 139

Podoxi-185

Pep-plus-342

PFC-324

Pioglin-139

Pofol-388

Pep-sweet-348

Phacovit-425

Pioglitazone- 138

Poizena- 139

Peptacid-4

Phagocin-198

Piol- 139,142

Pol plus-240

Peptid-1 5

Pharma saline-351

Piolit- 139

Pol-238

Peptidin- 1 5

Pharmacid-4

Piomet- 142,143

Polan-274

Peptil-H-1 5

Pharmapam-98

Piomin-143

Polimine-307

Peptin-340

Pharmapen- 1 6 1

Pipecuromium-bromide-

Poliomyelitis vaccine-

Peptonil- 1 5

Pharmatrim-205

394

383

Peptosol l.V- 1 5

Pharmavit-331

Piracetam-127

Poli-oral-383

Peptosol-DS-4

Pharmoxyl-168

Pirarnil-41,53

Politor- 143

Perex-330

Pharodin-303

Piriton-268

Politrim-205

Peri- 1 2

Phenadryl-269

Piroxicam-260

Polycef-174

Peridol-l03

Phendrin-269

Pitocin-405

Polycort-429

Perigen- l03

Phenerex-270

Pitofen-245

Polydex-N-41 5

Perilac-392

Pheniramine maleate-270

Pivacain-399

Polydin-303

Povidine-303,423 Povidone-iodine 302,303,407,41 2 Povin-303,304 Povisep303,304,407,412 Povital-324 Power gold-326 P-phos-231 PPI- 1 8 Pram- 1 8 Prandil-138 Prazo-19 Prazole- 19 Prazosin-38 Precare-344

Afix

The only cliriically tested cefpodoxime brand in Bangladesh

".1

.. ARISTOP HARMA LTD. Manufacturer of PharmaceutIcal Products

The 1 sr"Orai

3rd generation cephal()sporin

/":../>" .-

Perilax-396

Pheno- 122

Pivicil-170

Polyethylene glycol-28

Perinase-433

Phenobarbitone-97,122

Pivmecillinam- 170

Polyferon-307

Perindal-52

Phenoson-122

Pizide- 135

Polyfer-Z-3 1 5

Perindopril-40

Phenoximethyl

Pizo-A-245

Polymix-4 12

Perion-1 2

pemicillin-161

Pizofen-245

Polymix-G-41 2

Peripril-40

Phenytoin-122

Pizotifen-245

Polymix-H-429

Perkinil- 1 27

Pheraminc268

Pizotin-245

Polymycin-4 1 2

Perkirol-126

Phidazole-230

P-Lac-28

Polyron plus- 3 1 1

Perkup-442

Phospholipid-95

Placent-B-326

Polyron-307

Perls-284

Phylopen-l 64

Placent-E-329

Polytar-292

Perlutex- 1 5 1

Phytomenadione-68

Placent-M-342

Polytetra-278

Perma-284

Phyton-318

Placid-4

Polyton-2306

Permenin-284

Piazol-18

Pladex-67,68

Polytracin-412

Permethrin-283

Piglit- 139

Plagrin-67,68

Polyzyme-30

Permin-284

Pilestop-29

Platosin-368

Postinor-2- l 59

Permisol-284

Pilex-30

Plavix-67,68

Pot. permanganate-304

Perol-103

Pilocarpine-421

Plexivit-326

Potassium guaiacol-94

Perosa-284

Pilocarpine-OSL-42 1

Plexivit-M-342

Potassium salt-352

Perpen- l64

Pilodrop-42 I

P-min-137

Potassium-352

Pethidine-242

Pilomin-421

Podo- 185

Potassium-iodide- 145

Precinol-35 Preclot-67,68 Precodil-146 Prednelan-146 Prednicortil-146 Prednisolone- 146,4 16 Prednol-416 Preduet-238 Prefer-238 Prefid- 138 Preform- 137 Pregaba-122 Pregabalin-122 Pregaben- 122 Pregestimil-348 Pregmin-3 1O Pregmin-Z-314 Pregnacare-3 1 6 Pregnial-3 1 6 Pregnyl-154

Clopigel

QIMP·15 (524)

®

Clopidogrel Tablet

�

PACI F I C

Pregvit-3 1 1 Preloc-38 Premarin-148 Premicon-148 Premil-138 Prenat plus-3 1 1 Prenatal-3 14 Prenat-CI-3 14 Preneed-314 Prentox-330 Presec-18 Preserving-249 Presonil-38 Pretin 0-276 Pretin-274 Prevas- 1 9

Promodin-270

Provit-B-326

Q-rash-293

Pronac-254

Proviten A-Z-346

Quetiapine- 104

Pronapen- 1 60

Proviten silver-347

Qugyl-230

Pronex-20

Provoxia-19

Quibron-T/SR-83

Pronil-230

Proxen-260

Quiet- 105

Procap-19

Pronor-402

Proxid-331

Quin-H-232

Procef-174

Propantheline-8

Prozen-270

Quinine-232

Proceptin-19

Propanthene-8

Prozol-230

Quinoflox-214

Procet-272

Propenta-22

Prudex-91

Quinolex-23 1

Prochlorperazine- 1 1 5

Propin-19

Pseudoephedrine-430

Quinox-209

Procin-209

Propofol-388

Psudonil-194

Quixin-213

Proctil-185

Propranol-35

Pulmolin-76,78

Qutipin- l05

Procyclidine- 126

Propranolol- 34,245

Puregon-153

Prodep- l l0

Prosan-43

Purifen-250

Profen-256

Prosfin-402

Purin-445

Profenac-254,263,417

Prosma-84,417

Purinethol-366

Profenid CR-258

Prosobee-348

Purisal-78

Profenid-E-258

Prosol-350

Pycuron-395

Profix-182

Prostacin-403

Pylotrip-24

Proflam-254

Prostam-403

Pyra plus-240

Proflox-209

Prostig-397

Pyrac-338

ARISTO Gold

HIgII pcMncy32 MuIIMI8mIn . MIIItImIMnI TIIbtII

A to Z

'.1

Prezium- l00 Pricard-41 Prid- 135 Primace-41 Primaquine-23 I Primocef-179 Priocin-197 Priorix-383 Priovit-330 Pristin-58 Pristin-ol-50 Probac-179 Probenecid-264 Probitor- 1 9 Procala-334 Procaim-l OO

Raciprox-209

:

••

..•

Vanilla flavoured

.. ARISTOPHARMA LTD.

Prexim- 182

Race-331

Nutrition for everyday life

The multivitamin & multimineral syrup A to Z for kids

Prexan-146

Racard-41

. . . . . • ,.

Multivitamin and Multimineral Syrup

Prevencid- 19

Rabeprazole-22 Rabies vaccine-383 Rabipur-383

Adv;nced fO/TTIul.

ARISTO Kid

Previp-9

R.

Manufacturer of Pharmaceutical Products

{'" -"

Su�,�!:.f!'ee ""'1

./

Rad- 174

Progan-270

Prostol-39

Pyralgin-338

Progesterone-148

Protace-53

Pyralvex-304

Proglid-134

Protear-423

Pyramol-239

Progut-20

Protebon-334,337

Pyrantel pamoate-235

Proktnd-8

Protebon-0-336

Pyrazinamide-215

Proladin-254

Protec-41 ,230

Pyrenol-240

Proler-272

Protec-R- 15

Pyridoxine-B6-322

Prolert-1 10

Protein prepn-349

Pyrimac- 1 1 5

Proliv-349

Protium-22

Pyrimethamine-3 32

Prolok-19

Protix-12

Pyrison-332

Proma-270

Protogyn-23 I

Pyrol-322

Promalex-M-270

Protolan-21

Pyrovit-322

Promat- 1 1 5

Protoloc-22

Pyroxin-322

Promel plus-240

Protonil-22

PZA-CffiA-215

Ramoril-41

Promel-238

Proton-P-22

Promergan-270

Protopa-22

Ranbex- 1 5

Promestin-270

Provair-85

Q.

Promethazine-

Proval-123

Qlev-2 13

Ranflox-209

97, 1 1 5 ,270

Provia-303

Qnol-209

Promezinc270

Proviron-3 1 1

Qpro-209

Radex-103 Ralox-360 Raloxifene-359 Raltrox-242 Ramace-4 1 Rarnicard-41 Ramicol-201 Rarnil-41 Rarnipress-41 Rarnipril-40 Rarnipro-41 Ramoril Plus-54 Rampril-41 Randamycin- 193 Rani- 150-15 Ranibizumab-425

QIMP-15 (525)

Remacin-268

Ranid- 1 5

Recofast-179

Ranidil- 1 5

Recofol-388

Remacort-N-289

Ranidin- 1 5

Recombinant chorionic

Remadon- 1 2

Raniloc- 1 5

gonadotrophim- 154

Remadrin-430

Ranison- 1 5

Reconil-263

Remagyl-230

Ranisyn- 1 5

Recova plus- 3 1 6

Remalgin-239

Reovit-446

Ranit- 1 5

Recova-3 1 1

Remamox-168

Repace H-54

Ranitab- 1 5

Recular-417

Remaplex-326

Repace-43

Ranitack- 1 5

Recur-402

Remaprost-422

Repaglid- 1 3 8

Ranitec- 1 5

Red plus-3 1 3

Remathrin-284

Repaglinide-138

Ranitid- 1 5

Redema-48

Remavit-33 1

Repitol- 126

Ranitidine- 14

Rednisone-147

Remavit-M-342

Replet-67,68

Ranitor- 1 5

Redux-128

Remazin-235

Repose- I l l

Ranix- 1 5

Reelart-275

Remood- 103

Repres plus-52

Ranoxen-260

Reetac-R- 1 5

Remox-49

Repres SR-46

Rantec- 1 5

Refain-254

Remoxin- 168

Repro-260

Rantin- 1 5

Refemoline-41 5

Remus-295

Requin-263

Ranul-15

Reflor-274

Remylin- 3 1 8

Resco- 105

Ranvit-B-326

Refol-Z TR-3 1 3

Rena saline-35 1

Rescure- 1 83

Ranzith-198

Reglin- 1 3 8

Renac-254

Rescuvolin-367

Rapid-C-328

Regtin-205

Renamycin otic-428

Resdil-76

Axo n

Ceftriaxone 250 mg, 500 mg,1g IVAM & 29 IV

Reumazin-26 Reutren gel-255 Reutren-254,255,4 17 Reuwolfia prepn-440 Revam gold-346 Revam kids-321 Reversair-85 Revigor-344 Revistar- 164 Revital-346,347 Revoc- 1 7 5 Rex-33 1 Rezulin-143 Rhemex-444 Rheudene-261 Rheufen-444

Injection Cefuroxime Axetil Tablet Powder for Suspension & Injection

The trusted ceftriaxone brand in Bangladesh .. ARISTOPHARMA LTD_ ,... Manufacturer of Pharmaceutlcal Products

The pregnancy friendly antibiotic

�'!l� '" �

Rapidol-243

Regulose-28

Renamycin-

Reservix-249

Rapilax-395

Rejoin-361

193,278,4 1 1 ,428

Reset plus-240

Rapofen-256

Rejubion-324

Renapa-8

Reset-239

Rasat-205

Rejuven-334

Renaton-444

Resitone-48

Rashguard-293

Rejuven-D-336

Renb-E-329

Resopan-7

Rasonix-23

Relacs-28

Renep-324

Respazit- 1 98

Ratinol-3 1 9

Relafin- 1 1 0

Renerv plus-322

Resperdex- 1 05

Ravia- I S

Relapan-7

Renerv-321

Respira-78

RE- 19

Relaxen-98

Renicon- 1 5

Respolin-76

Reactin-269

Relaxium-99

Renoit-324

Resquin- 2 1 3

Rebion-324

Relaxton-394

Renova-239,240

Restol-99

Reboseem-322

Relentus-267

Renxit- 103

Restophylline-82

Rebufen-256

Relergy-275

Reocef- 1 75

Restovit-327

Rebuprofen-256

Releve-260

Reomen- 153

Restovit-M-33 1 ,342

Rec-439

Relexid- 170

Reoplex forte-322

Retin-A-297

Recal-448

Relitch-30

Reoplex plus-3 1 5

Retinoic acid-37 1

Recard-35

Relux-103

Reoplex-326

Reufen-256

Recef- 174

Rem-99

Reoplex-M-342

Reumac-444

Recin-409,428

Remac-200

Reovan H-55

Reumacap-257

Recocid-4

Remacid-4

Reovan-44

Reumafen-256

Rheuma-249 Rheumacon-444 Rheumet-257 Rhine- I S Rhinil-272 Rhinozol-43 1 Rhythm- l 97 Ribaplex-327 Riboflavin-322 Riboflavine-322 Riboflavine-B2-322 Ribosina-322 Riboson-322 Ribotab-322 Ribovit-322 Rice saline-352 Rice-based saline-351 Riden-74 Ridon- 1 3 Rifagen-21 5

The nxet ® Flupenthixol + Melitracen Tablet

QIMP·15 (526)

�

PACI F I C

Rostid- 1 5

Sac-sweet-348

Salpium-83

Rostil-8

Sadin- 1 5

Saltamin-268

Rosuva-73

Saduri-44 I

Saltonate-334

Rosuvastatine-73

Safamin-268

Saltrim-206

Rotafen-254

Safe-33 I

Sandocal-334

Rifampicin-21 5

Rocef- 175

Rotamin-143

Safenac-TR-254

Rifatan-2 1 5

Sandom- 1 3

Roceptin-19

Rotarix-383

Safetisol-302

Rifcin-2 1 5

Sandostatin-376

Rocin-209

Rotavirus Vaccine-383

Safex-245

Sanit-1 1 3

Rimactane-21 5

Rocipro-209

Rotek-392

Saffodin-438

Sanolocal-D-336

Rimactazid-215,216 Rimstar 4-FDC-2 16

Rocky-200

Rotex-1 3 1

Safi-445

Sante-334

Rocuronium-395

Rova-8

Safkin-445

Santogen A-Z-346

Ringer's solution-354

Rodamin-269

Rovamycine-200

Safwash-302

Santox-343

Ripril-41 ,54

Rodipine-58

Rovantin-185

Saga-214

Sapclo-249

Riscord- 105

Rofecin- 188

Roxal-92

Saglit- 139

Sapen-7

Risdon- 1 05

Roferon-A-374

Roxcin-200

Sakti-TR-3 1 3

Sapox-168

Risedronate-358

Rofixim- 183

Roxen-260

Salazine-26

Sardopa-34

Rison-396

Roflam-256

Roxetil- 1 85

Salazopyrin-26

Sarinex-275

Rispa- 105

Rofurox-179

Roxicef- 175

Salbu-76

Sarinex-D-277

Risperidone- l 05

Roglim- 1 4 1

Roxim-1 83

Salbut-76

Sarlo-43

Rispolux- 105

Roglit- 140

Roxipar-2 l 4

Salbutal-76

Sarmox-234

Rit- 1 88

Rogmet-143

Roxithromycin-200

Salbutamol-75,76

Sartec-272

Enteric Coated Tablet

Film Coated Tablet

Reu maz i n

Mervan

Su lfasalazine

The potent NSAID for effective

mg

US FDA approved drug for Rheumatoid Arthritis

management of RA & OA

".1

500

.. ARISTOPHARMA LTD. Manufacturer of Pharmaceutical Products

/'" .-

"

' ?,

.../

Rito-256

Roket-392

Roxyl- 168

Salclox- 1 6 1

Sartra-1 1 l

Rituximab-373

Rolac-392

Rozam-98

Salferon-306

Satrol-272

Rivamer-1 29

Rolacin-200

Rozavel-74

Sa1flox-209

Savedin-303,304

Rivarin-223

Rolage-360

Rozinc-340

Salflu inhaler-89

Saver- 1 83

Rivastigmine-1 29

Rolid-200

Rozith-199

Salicylic acid-295

Savlon-302

Rivin-322

Rome- 1 9

R-pil-4 1

Saline-3 5 1

S-biol-283

Rivotril- 1 l 9

Romerol- 1 40

R-saline fruity-351

Salinix-247

Scabex-283,284

Rixol-92

Romycin- 198,199

R-saline-35 I

Salirub-247

Scabicid-283

Riz-272

Ronac-TR-254

RT 150- 1 5

Salix-76

Scabicon-283

Rizamig-244

Ronem- l92

Ruba-444

Salmate-79

Scabid-284

Rizat-244

Rooh Afza-446

Rutix- 1 l4

Salmeterol-79

Scabisol-283

Rizatriptan-244

Ropenem- l 9 2

Rymin-269

Salmol-76

Scabo-283

Rizelium-246

Ropinirole- 126

Rynaspray-43 1

Salmolin-76

Scanil-283

Rizin-272

Ropinol- 1 26

Rynex-43 I

Salmon calcitonin-356

Scaper-284

Roaccutane-298

Rosatan-43

Ryth-200

Salocin-214

Scarin-284

Robazam- lOO

Rosatan-H-54

Salol-76

S-citapram- 109

Robic-230

Rosiglitazone-139

Salomax-76

S-clon-98

Rocal-334,337

Rosimet-143

Salora-275

Seas plus-321

Rocal-D-336

Rosimin-143

S-26-348

Saloride-353

Seasonix-274

Rocaltrol-320

Rosit-140

Sacona-226

Salpac-353

Sebivo-222

S.

®

N o ra d P l u s

QIMP-15 (527)

Seclo-1 9

Sefanid- l72

Sergel-20

Secnid-230

Sefatil- 179

Seridol-239

Secnidal-230

Sefdin- 175

Serifen-250

Secnidazole-230

Sefin-175

Serolux- l l l

Super Antioxidant Vitamins

& Minerals

Soft Gel Capsule

iii

PAC/F I C

Secnizol-330

Sefox- 185, 1 86

Serozid- 186

Secotal-290

Sefrad- 175

Sertal- l l l

Silvadazin-280

Sitrim-206

Secrin- 135

Sefrate- 175

Sertraline- l l l

Silvage-347

Siznil- l04

Sectil- 1 9

Sefril- 175

Servex-249

Silvazin-280

Sizodon- l05

Sedapen-98

Sefro-175

Serviflox-209

Silver sulphadizine-280

Sizonil-I O I Sizopin- 102

Sedaquil-95

Seftec-175sephar- 175

Servimeta-257

Silverzine-280

Sedatab-98

Seftol-302

Servin-3 l l

Simacor-74

Sizopra- l04

Sedate-98

Seftrlm-206

Servinaprox-260

Simecol-6

Skben-DS-235

Sedil-98

Sefty-175

Servipep-14

Simethicone-5

Sk-cef- 176

Sedilux-M-268

Sefur- 179

Setic- 183

Simgel-4

Skilin-284

Sedium-98

Sefurox-179

Seton- l l 8

Simicon-6

Skilox- 1 74

Sedno-275

Segal-226

Setra- l l l

Simox-168

Skinabin-282

Sedron-354

Sejin-442

Sevdol-302

Simpiclox- 1 6 1

Skinaderm-290

Sedulin-98

Selecox-250

Sevenseas codliver oil-

Simpli-3-199

Skinalar-288

Seduxen-98,99

Selegiline- 126

320

Simvastatin-74

Skinalar-N-288

See-cal-334

Selexid- 170

Sevofluran-390

Simvatin-74

Skinovat-287

Seema-C-328

Selomet-38

Sevorane-390

Simvit M-342

Sk-mox-168

Film Cooted Toblet

ZnF Zinc & Folic Acid

The revolution in iron th

,.••

.. ARISTOP HARMA LTD_ Manufacturer of Pharmaceutlcal Products

;'t.' :"o,

� ::/

Seemaceph- 171

Selotin- l l l

Sezol-DS-230

Simvit-B-327

Skybiol-283

Seemacid-4

Semecon-6

S-fenac-254

Sina silver-347

Skycid-T-4

Seemacillin-165

Semotrim-206

S-fluclox- 164

Sinaceph- 175,176

Skycillin- 165

Seemagyl-230

Senac-A-249

SG-plus-327

Sinaclox- 161

Skydon- 1 3

Seema-K-352

Sennoside-27

Sil,Jex-282

Sinacort-285

Skymol-239

Seemaldrat-4

Sensinet- 143

Sibulin- 128

Sinaferon-309

Skymoxin-168

Seemaplex-3 15,327

Sensipin-l02

Sibutramine- 128

Sinaflox-164

Skytex-233

Seemaplex-B-327

Sensit- 103

Sibutrin- 128

Sinafort-B-327

Skytrin-206

Seemapyrin-66

Sensulin-140

Sicef- 175

Sinagold-346

Skyvit plus-342

Seemaquine-231

Sentix- 102

Sidobac- 186

Sinalax-27

Skyvit-327

Seematrin-206

Seovin-224

Sidopin-58

Sinarnin-268

Sleepen-98

Seemavit-331

Sepnil-302

Sidoplus-50

Sinamox- 168

Sleepil-98

Seemavit-M-342

Sepra- 175

Siesta-99

Sinapol-239

Sleepwel-98

Seemaxyl- 168

Septa- 175

Sifen-254

Sinatrim-206

Slipam-96

Seemet- 1 4

Septra-206

Siflam-256

Sinazid-134

Smile-94

Seemox-234

Sera- l l l

Silbum-280

Sinecod-434

Sodamint-6

Seequil-99

Serelam-99

Silcream-280

Sinex-248

Sodi-bi-carb-354

Sefacin-175

Serelose-28

Silora-275

Singlin- 1 3 8

Sodicrom-418

Sefadol- 1 7 1

Seren- 1 1 0

Silox- l 64

Sintel-235

Sodium bicarbonate-354

Sefalor- l77

Seretide-89

Silpa-239

Sirdalud-267

Sodium cromoglycate-83,418,432

Panprazo® 20 ii

QIMP-15 (528)

Pantoprazole Tablet

PACI FIC

Sodium

Spalocin-214

dichloroisocyanurate-25

Spalox-2 14

Sodium fusidate-28

Span-8

Sodium hyaluronate-361

Spanil-7

Sodium nitroprusside-44

Spar-214

Sodium valproate-122

Sparcin-214

Sofa- l64

Spardon-214

Softapen- l 64

Sparflox-214

Softi-294

Sparfloxacin-214

Solas-233

Sparfloxin-214

Solbion-324

Spark-214

Soloteas-4 1 2

Sparlin-2 14

Solrin-66

Sparonex-214

Solu-medrol- 147

Spasalgin-9

Soluzinc-340

Spasmopin-7

Solvit-M-342

Spasmoson-7

Stano-M-342

Suev- l 1 14

Stanoplex-327

SuffIX- 1 83

Supravit-G-346

Stanovit-B-327

Sugamet-137

Supravit-M-343

Stanovit-M-342

Sugana- 141

Supravit-PN-345

Staphylox- 1 64

Suganil- 133

Suprax- 1 83

Stapkil- l64

Sugatrol-137

Supraxim-183

Starin-186

Sugel-5

Suprim-206

Starlix- 1 3 8

Sulbion-76

Sural-2 1 5

Starzyl-230

Sulfarnin-232

Suranj an-444

Staxim- 179

Sulfazin-26

Surgeflox- 1 64

Stela- l O l

Sulidac-261

Survanta-95

Stelone-290

Sulin-261

Sustanon- 152

Stemetil- 1 l 5

Sulindac-261

Sustogen- 1 5 2

Stenicol-414

Sulphacetamide-4 1 1

Sutac- 1 5

Sterisol-4OJ

Sulphadiazine-204

Suvic-328

Steron-146

Sulphadirnidine- 204

Suxa-395

Stigrnin-397

Sulphasala zive-26

Suxamethonium-395

Stignal-397

Sulphasalazine-204

Suxen-260

Stilarnin-157

Sulprex-83

Suxonium-395

Stimulin- 135

Sultolin-76,77

Suzaron - 1 l 4

Stoma-4

Sultolin-SR-76

SycJofen-249

GLUCOZ, I D

GLUCOMET Metformin 500 & 850 mg Tablet, 500 XR & 750 XR Tablet

G liclazide 80 mg Tablet

The trusted metformin brand in Bangladesh .. ARISTOPHARMA LTD_ ,... Manufacturer of PharmaceutIcal Products Solvitone-327

Spasmozen-7

Som-20- 19

Spasverin-8

Soma-DS-206

Specbac-192

Somatostatin-157

Spectinomycin-202

Somatropin-155

Spectra-209

Sorninex-98

Spectraban ultra-30 1

Somnolent-98

Sperid- l05

Sompraz-20

Spersallerg-4 1 9

Sonap-260

Spiramycin-200

Sonexa- 146,414

S-pirin-66

Sonexa-C-4 14

Spironolactone-47

Sono-98

Sporin- 176

Soritene-291

SpotcJen-300

Sos saline-35 I

Sprinkles-3 16

Sotalex-33

Spulyt-93

Sotalol-32

Sputen-93

Soto-199

Sq�mycetin-408,427

Spa-7

Stacor-72

Spacin-214

Stafen-84,417

SpaJax-7

Stafoxin-164

Supravit-3 3 1

More than a su lfony l u rea �o. ' :'\\�)) I

" "",,;$iF

�\' :::/

Syflu- 1 64

Stomacid-4,5

Sumatriptan-244

Stonex-31

Sumetrolim-206

Syrnin-268

Streptase-68

Surnigran-244

Synac-206

Streptokinase-68

Sunac-254

Syndol-243

Streptomycin-214,2 1 5

Suparipak-448

Syndopa- 125

Stril-40

Super gold-346

Synergy-343

Sualin-441

Supervit-327

Synflex-361

Subramycin-194

Supervit-B-327

Synovate-287

Sucal-334

Suplecal-334

Syntocin-405

Sucomet-137

Suplevit-M-343

Syn-Z-3 16

Sucotab-134

Suplical-D-336

Sypron-209

Sucralfate-23

Supra- 3 1 5,324

Syrup zinc-340

Sucralose-348

Supracef- 176

Syrup-ZP-340

Sucrol-348

Supracool-321

Systear-423

Sudafed-330

Suprafol TR+Z-3 1 3

Systene-422

Sudo plus-277

Suprafol-TR-3 l O

Sytrim-206

Sudocof-91

Supralex- 1 7 1

Sytrol-272 '

Sudolor-277 ' Sudorin- 430

Su'praphen Plus-427

Sudotab-430

Supraplex-327

Supraphen-408,427

T_ Tablet-E-V-327

l OCln e·l · ®,

QIMP-15 (529)

Tacrol-295

T-drop-41 1

Terbifin-227,283

Tacrolim-295

Tear-422

Terbinafine-227 ,282

Tacrolimus-295

Teargel-423

Terbutaline-78

ii

PAC I F I C

Tag-210

Tears Naturale-423

Tergocin-203

Tamadol-243

Tearsol-422

Termider-283

Tamen X-240

Tegarid-26

Ternilla-249

Theophylline-82

Tifen-84

Tamen-239

Tegaserod-26

Terovit-3 1 8

Theovent-82

Tigicon-71

Tamiflu-224

Tegretol- 1 l 8

Tervent-78

Thia- I-321

Tiginor-73

Tamisol-403

Teicoplanin-203

Tesod-26

Thiabin-32 1

Tigirate-7 1

Tamlosin-403

Telabid- l 0

Testanon- 1 8 1

Thiamine (B l )-32 1

Til- l 7 8

Tarnol plus-240

Telazine- I O 1

Testosterone- 152

Thianomin-321

Tila jaded-443

Tamol-239

Telbivudine-222

Tetabulin-386

Thiason-32 1 ,322

Tila-e-jadeed-443

Tarnona-375

Telfin-227,282

Tetanus vaccine-384

Thiatab-322

Tilcotil-262

Tamosin-403

Telmisartan-44

Tetanus-antitoxin-384

Thiobion-322

Tilex-360

Tamoxen-375

Telsast-273

Tetanus-toxoid-384

Thiodrop-25

Timem-9

Tamoxifen-375

Telviral-222

Tetclin- 193

Thiolex-322

Timidal-239

Tamsulosin-402

Temlo-42I

Tetracin-4 1 1

Thiopen-388

Timoben-9

Tandamol plus-241

Tempac-239

Tetracline- 193

Thiopentone sodium-388

Timodrop-421

Tandamol-239

Tempil-239

Tetracomb-290

Thiopentone-rotex-3 8 8

Timolat-421

Tanox-3 3 1

Tempol plus-241

Tetracycline-

Thiosina-322

Timolax-9

Tanox-plus-343

Tempol-239

192, 1 93,278

Thiotab-25

Timolin-9

Amlodipine 5 mg plus Atenolol SO-mg Tablet

Lacldipine

An effective fiXed dose combination f9r hyp;�rtensi9n

2 mg & 4 mg Tablet

Better than amlodipin'e

Taracycline-4 1 1

Temrif plus-241

Tetracyn-193

Thioton-388

Timolol-421

Taran-43

Tenafin-282

Tetragen- 193

Thiovit-322

Tirnolol-Osl-421

Tarceva-369

Tenapam-99

Tetraicin- 193

Thiza- 199

Timomin-42 1

Tasti-331

Tenaxit- 103

Tetralin- 193

Throcin-197

Timopress-42 1

Tasty saline-35 1

Tendia-243

Tetram- 193

Thromax-199

Timothy-9

Taven-73

Tenil-99

Tetramet-193

Thyronor- 145

Timotor-9

Taverin-8

Tenocab-50

Tetramin-193

Thyrox-145

Timozin-9

Taxetil-186

Tenocard-35

Tetramycin- 193

Thyroxine- l 44

Tinadin- 1 5

Taxim- 1 84

Tenol-35

Tetrasina- 193

Tiapine - l 05

Tinafate-283

Taxol-371

Tenoloc-35

Tetrasol-283

Tibolone-156

Tinatrim-281

Taxotere-368

Tenoren plus-50

Tetrax-193

Tibone- 157

Tinazole-281

Tazarotene-291

Tenoren-35

Tetrazen- 1 9 3

Tibs-26

Tinidazole-23 1

Tazid-1 86

Tenoxicam-261

Texco-9 1

Ticamet-89

Tiniril- 1 1 6

Tazon-140

Tensa- 103

Texit- 1 83

Ticas-288

Tinium-9

Tazonid-25

Tensnil-IOO

Tgocef- 1 83

Ticason-288

Tino-9

Tazoskin-29 1

Teolex-82

Thalidon-46

Ticlon-98

Tinobac-202

Tazox-25

Tequin-210

Thenglate-82

Ticoflex-260

Tiny-Z-340

T-Cef- 1 83

Terazon-39

Thenxet- 103

Ticonazole-282

Tioconazole-407

TCL-R-73

Terazosin-39

Theoglate-82

Ti-ediplex-322

Tiotropium-80

T-dex-4 1 5

Terbex-227,283

Theonate-82

Tiemonium-9

Tioxil-424

M ag m i l ® The Super Laxative Susp.

QIMP-15 (530)

iii

PACIFIC

TPC-324

Trifluoperazine- l 0, 1 0 1

TPS-388

Trifol-TR-3 1 3

Trophen-420

Tracid-69

Trigent-71

Tropicam-41 9

Tracrium-394

Trigone-443

Tropicamide-419,420

Tralin- I l l

Triject- 189

Tropicamide-Osl-419

Troniz-230

Tiramine-272

Tolterodine-403

Tramadol-243

Trileptal-122

Tropicamin-4 19

Titacin- 193

Toma-84

Tramal-243

Trilix SR-46

Tropidil-41 9,420

Titolax-27

Tomephen-90

Tramapan-243

Trilock-85

Trova-73

Titos-9

Tomycin-4 12,415

Tramic-69

Trilon-2 1 3

Trucef- 1 86

Tivanik-213

Tomycin-D-41 5

Tranal-243

Trimazole-281

Trufen-256

Tivizid-219

Tone-322

Tranexamic acid-69

Trimcort- 147

Trulax-78

Tixol-103

Tonemide-48

Tranquil-IOO

Trimebutine-9

Trum- 1 86

Tizadin-267

Tonoca1cin-356

Trastuzumab-372

Trimet-60

Trumen-243

Tizanidine-266

Top-258

Travast-422

Trimetazidine-60

Trupan-22

Tizem-58

Topain-258

Travatan-422

Trimetrin-206

Trusil-41 9

T-mycin-4 1 2

Topamax-124

Travoprost-422

Trimovax-383

Trusil-plus-420

Tobi-4 1 1

Topcef- 188

Trax- 188

Trin-272

Trusiva-91

Tobidex-415

Toperin-396

Traxon- 1 88 , 1 89

Trinil-94

Tobirax-41 1

Topex-94

Traxyl-69

Trinon-297

Truso-183 Truzith� 199

Tobra-41 1

Topicacin-247

Trego-279

Triocef- 1 83

Tryptin- 1 06

Tobrabac-411

Topical urea prepn-299

Tretinoin-297

Triocim- 183

Tuac-28

Meta��MR Modlf.ed Retease Tablet

Tdb let

Nitrocard

Susta,ned Release

Nitroglycerin 2.6 mg

Trimetazidine Hydrochloride 35 mg

The right nitrate therapy for angina

,.•• Manufacturer of Pharmaceutical Products

.. ARISTOPHARMA LTD.

An innovative modified release formulation for angina :.,\\\' 1 21').

Q " ,,�

�,

�

Tobracin-4 1 1,412

Topican-398

Trevox-2 1 3

Triomid-8 l

Tobramin-412

Topicort-288

Trexam-69

Triovix-220

384

Tobramycin-41 1

Topiramate- 123

Tri-324

Triozol-290

Tuffox-249

Tuberculosis vaccine-

Tocef-1 83

Topirva-124

Trialon-147

Trip- 106

Tufnil-262

Todol-392

Topium-8 l

Trialon-290

Tripec-94

Tulobuterol-79

Tofa-260

Topra-22

Triamcinolone-

Triphen-94

Tulos-28

Tofen-84

Topress-38

147,290,433

Triphin- 1 89

Tumy-334

Tofranil- l07

Topril-39

Tribac-189

Triple therapy-23

Turbid- l72

T-ointment-41 2

Topsil-93

Triben-235

Triprim-206

Tusca-94

To1calm-396

Toradol-392

Tribion-324

Trispray-433

Tuscoff-95 Tussidex-90

Tolec-392

Torasemide-46

Tricef- 1 83

Tritace-41

Tolfenac-254

Torax-392

Tricid-5

Tritanrix-379

Tussin-95

Tolfenamic acid-262

Toraxim-186

Tricoderma-290

Trivit-3 3 1

Tussy-95

Tolin-77

Torolac-392

Tricof-94

Trizidim- 186

Twicef- l72

Tolmic-262

Torped- 1 84

Tricot-206

Trizin-272

Tybac-280

Tolnaftate-283

Tory-256

Tricozyl-230

Trizon- 189

Tycal-334,336

Tolorin-404

Tos-139

Tridex-94

Trocane-420

Tycil- 168

Tolperisone-396

Tosirin- 141

Tridosil- 199

Trocer-56

Tyc1osx- 1 6 1

Tolson-396

Toti-84

Triex-94

Trofurit-46

Tycon-282,407

Tolter-404

Toza-25

Trifix-183

Trol-243

Tydenol-239

Lipigent® 1 0 & 20 ii

QIMP-15 (531)

Tydin-176

Ultaran-254

Urbifen-435

Tydon- 1 3

Ultid-16

Urgotin-405

Tyfax-3- 1 83

Ultox-331

Uricon-402

Tyflam-256

Ultracaine heavy-399

Urilax-402

Tyflox-209

Ultracaine-399

Urilev-2 1 3

Tylen-239,24I

Ultracal-C-334

Urinom-403

Tylo- 1 9

Ultracal-D-336

Uriten-401

Tymin-268

Ultracarbon-29

Tymox- 168,169

Ultrac1ox- 1 6 1

Tynisol-33 1

Ultradin- 1 6

Tynium-9

Ultrafen gel-255

Tynol-239

Ultrafen plus-263

Typan-7

Ultrafen-254

Typherix-384

' Ultragram-400 -

Typhim-VI-384

Ultramet- 1 1 6

Typhoid fever vaccine-

Ultramox-169

384

Ultrapime-190

Ty-plus-241

Ultrasef- 176

Tyrex-95

Ultravit-B-327

Tytac- 1 5

Ultravit-M-343

Tytrol-272

Uneed-3 1 1

Tyzith- 1 99

Unibion-324

U_

Unicard-56 Unicort-288 Unicort-N-289

Uritol-404 Urodart-402 Uroflo-403 Vrokit-404 Urolosin-403 Uromax-403 Urornitexan-363 Urosin-403 Urospin-48 Vrsocol-3 1 Ursodeoxycholic acid-30 Ursodil-31 U-zyne-30

V_ Valapi- 123 Valex- 1 23

U4- 103

Unidone- 1 3

Ubilon- 157

Unidox- 1 94

Ucardol-37

Unifix- 1 83

Vcol-2-404

Uniflam-256

Ucorex-264

Uniflox-209

Ulbex-235

Unikon-82

Ulcar- 1 5

Unimox- 169

Ulcip-209

Unipime-190

Ulcitid-15

Uniplex-327

Uldom- 1 3

Uniquin-23 1

Ulfe-TR- 3 1 3

Unisaline-35 1

Uliv-3 1

Unitac- 1 6

Vancard-203 Vancornin-203 Vancomycin-202,203 Vanmycm-203

Valpress-44 Valpro- 1 23 Valsan-44 Valsartan-44 Valsartil-44 Valsartil-55 Valzide-55 Yamin glucose-350

Atorvastatin Tablets

Varizil-230

Verarnil-60

Vasco-328

Verapamil-59

Vasocal plus-50

Verben-235

Vasopin-50,58

Vercef- 1 86

Vasopril-40

Vergon- 1 1 5

Vass-73

Vermicom-233

Vastin-73

Verrnid-235

Fie

Vastocor-74

Verrnin-DS-235

Vave- 1 3

Verrnizole-234

Vaxem-380

Veron-8

Vaxtin-249

Verorab rabies vaccine-

VC-250-328

383

Vecarot-3 3 1

Verospiron plus-48

Vecef- 176

Verospiron-47

Vecuron-395

Verteporfm-425

Vecuronium-395

Vertex-149

Veesina-328

Vertigan- 1 15

Vegadon- 1 3

Vertina- 1 14

Velofix-183

Verve-345

Velogen-176

Vesanoid-371

Velox-176

Vesocal-58

Venax- 1 1 2

Vesodil-37

Venium- lOO

Vesol-288

Veniz- 1 12

Vesotan-42

Venlafaxine- 1 1 2

Vestarel MR-60

Venlax- 1 1 3

Vib-194

Venlet-77

Vic-3 1 1

Venofen-308

Vicard-325

Venol-77

Vicon-327

Ventisal-77

Vicon-M-343

Ventol-77

Victorin-186

Ventolex-77

Vidalin gold-346 Vidalin silver-347

Ulnid-230

Univit Plus-343

Vanprox- 1 86

Ventolin-77

Ulpanto-22

Univit-B-327

Vapo-123

Ventosol-77

Vidox- 1 94

Ulsec-23

Unix-284

Vaporex-248

Veracal-59,60

Vigantol-320

Ultac-16

U-pa-24 1

Varilrix-378

Veralgin-9

Vigil-230

Sefatil®1 25, 250 & 500 ii

QIMP-15 (532)

Cefuroxime Axetil

Tablets & Powder for Suspension

PACI F I C

Vitazin-3 1 5,342

Windel-77

Xenthol-247

Vitcod-321

Winkol-269

Xepadon- 1 3

Vitex gold-346

Winner- 1 89

Xepodox- 1 86

Vitex-327

Winop-392

Xeridon- 1 3

Winpain-243

Xerifen-249

Winspa-7

Xeriflam-249

Vitex-M-343 Vigo-3-324

Vitafol- 3 1 2,425

Vitolex-443

Vigo-fort-443

Vitaforce S-343

Vitolin-447

Vigor ACE-33 1

Vitaforce-331

Vitorric- 3 1 5

Vigor-B-327

Vitagrow-221

Vitoxi-3-3 3 1

Vigor-M-343

Vita-heart-325

Vitrocin-194

Wintack- 16

Xerosec- 1 9

Wormex-235

Xerova-73

Wormin-K-234

Xetril- 1 19

Worvex-233

Xfin-283

Wysoy-349

Xflam-250

Vimex-443

Vital E+C-331

Vitrum gold-346

Vimin plus-343

Vital-B-227

Vitrum silver-347

Vimin-331

Vitalex gold-346

Vitsa-327

Vinblastine-367

Vitalex-327

Vivis-424

Vincet-61

Xalatan-422

Ximepime- 1 90

Vital-M-343

Vizicon-316

Xamic-69

Ximeprox- 1 86

Vincristine-367

Vita-M-331

Vizinc-342

Xanax-99

Vinpocetine-61

Vitamin B 1 2-3 1 7

Vocet-274

Xanide-25

Ximetil- 179 Ximocef- 186

Vinton-61

Vitamin B6+B9+ B 1 2-

Volcan-254

Xanita-25

Xinc B-342

Viodin-303,304

324

Volmax SR-254

Xantid- 1 6

Xinc-340

Viola-304

Vitamin-A-3 19

Volog-288

Xbac-209

Xinoplex-31 5,342

Violete-304

Vitamin-B 1 +B2+B6-322

Volpro-254

Xcel-239,241

Xionil-99

Xido-134

X.

Xifim-183 Ximbac- 183

' Systear

Sonexa

Dexamethasone Phosphate 0.1%

Polyethylene Glycol 0.4%

& Propylene Glycol. 0.3% Sterile Eye Drops

.. ARISTOPHARMA LTD_ ,... Manufacturer of Pharmaceutical Products

Sterile Eye Drops

;"F..�::'

QIMP-15

Recommend Documents