Assistant Clinical Professor of Dermatology Case Western Reserve University School of Medicine Cleveland, Ohio
LONDON AND NEW YORK
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©2005 Taylor & Francis, an imprint of the Taylor & Francis Group First published in the United Kingdom in 2005 by Taylor & Francis, an imprint of the Taylor & Francis Group, 2 Park Square, Milton Park Abingdon, Oxon OX14 4RN, UK Tel Fax: Website:
+44 (0) 20 7017 6000 +44 (0) 20 7017 6699 www.tandf.co.uk
All rights reserved. No part of this publication may be reproduced, stored in a retrieval system, or transmitted, in any form or by any means, electronic, mechanical, photocopying, recording, or otherwise, without the prior permission of the publisher or in accordance with the provisions of the Copyright, Designs and Patents Act 1988 or under the terms of any licence permitting limited copying issued by the Copyright Licensing Agency, 90 Tottenham Court Road, London W1P 0LP. Although every effort has been made to ensure that all owners of copyright material have been acknowledged in this publication, we would be glad to acknowledge in subsequent reprints or editions any omissions brought to our attention. British Library Cataloguing in Publication Data Data available on application Library of Congress Cataloguing-in-Publication Data Data available on application ISBN 0-415-38380-3 Distributed in North and South America by Taylor & Francis 2000 NW Corporate Blvd Boca Raton, FL 33431, USA
Within Continental USA Tel: 800 272 7737; Fax: 800 374 3401 Outside Continental USA Tel: 561 994 0555; Fax: 561 361 6018 E-mail:
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[email protected] Composition by AMA DataSet Limited, Preston, UK Printed and bound by Antony Rowe Ltd., Chippenham, Wiltshire, UK
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CONTENTS Introduction
vii
Index of generic and trade names
ix
Classes of drugs
xxiii
Drug eruptions A to Z
1
Drugs responsible for common neurological reactions
v
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INTRODUCTION Any drug can cause any rash. According to the World Health Organization, an adverse reaction (ADR) – or adverse event (ADE) – to a drug has been defined as any noxious or unintended reaction to a drug that has been administered in standard doses by the proper route for the purposes of prophylaxis, diagnosis, or treatment. This definition does not include abuse, overdose, withdrawal, or error of administration. While most reactions are mild and self-limited, severe and life-threatening reactions do occur, as seen in Coma and Stroke. Death is the ultimate adverse drug event, and has now been incorporated into the book. ADRs are underreported and thus are an underestimated cause of morbidity and mortality. The incidence and severity of ADRs can be influenced by age, sex, disease, genetic factors, type of drug, route of administration, duration of therapy, dosage, and bioavailability, as well as interactions with other drugs. It has been estimated that fatal ADRs are the third or fourth leading cause of death in the US. This pocketbook of Neurological Drug Reactions and Interactions describes and catalogs the adverse effects of over 260 commonly prescribed and over-the-counter generic drugs and herbals used in neurology or having neurological side effects. These drugs include classes such as Anticholinergic agents, Anticonvulsants, Antimigraine agents, Anti-Parkinsonian agents and Neuromuscular blockers. The drugs have been listed and indexed by both their Generic and Trade (Brand) names for easy accessibility. In addition to adverse drug reactions, there are many severe, hazardous interactions between two or more drugs. I have
vii
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incorporated only the clinically important, potentially hazardous drug interactions that can trigger potential harm, and could be lifethreatening. These interactions are predictable and well documented in controlled studies; they should be avoided. For each drug, I have listed the known adverse side effects – in the form of drug reactions – that can develop from the use of the corresponding drug. These include reactions involving the skin, hair, nails, eyes, hematopoietic, cardiologic and other side effects. The section entitled 'other' includes such reactions as tinnitus, serotonin syndrome, depression, rhabdomyolysis, insomnia, and death. The first part of the book lists, in alphabetical order, the Generic and Trade name drugs with their corresponding names for easy access to the A-Z section – the main body of the book. Next comes a listing of the various Classes of drugs, and those Generic drugs that belong to each class. The last part of the book includes listings of common neurological reactions caused mainly by nonneurological drugs. The major portion of the pocketbook – the body of the work – lists the Generic drugs, herbals and supplements in alphabetical order and the adverse reactions that can arise from their use. The numbers in square brackets refer to the number of references recorded for each reaction. These references are available on my website (www.drugeruptiondata.com) or in the latest edition of the Drug Eruption Reference Manual.
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viii
INTRODUCTION
USAGE, STYLE & CONVENTIONS EMPLOYED IN THIS POCKETBOOK The Generic Drug name is at the top of each page. The Trade (Brand) Name(s) are then listed alphabetically. When there are many Trade Names, the ten (or so) most commonly recognized ones are listed. This compilation lists and cross-references both the Trade and Generic names of all the cataloged drugs. Following the more common Trade Name drugs are recorded – in parentheses – the latest name of the pharmaceutical company that is marketing the drug. Beneath the Trade Name listing is a list of Other Common Trade Names, those drugs from other countries. Then appear the Indication(s), the Category in which the drug belongs, and the Half-Life of each drug, when known, and the Potentially hazardous interactions between drugs. On occasion, an important or pertinent Note will follow. Reactions: These are the Adverse Reactions to the particular Generic drug.
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They are classified into Categories: Skin, Hair, Nails, Hematopoietic, Eyes, Cardiologic, and Other. (Other refers to Mucous Membrane, Teeth, Muscle and various other Reactions.) Reactions are listed alphabetically under each heading. Alongside each Reaction Pattern are square bracketed numbers that refer to the number of references in the main Drug Eruption Reference Manual and my website. Numbers in round brackets refer to the incidence of the reaction, e.g. (3 cases) or (15%). In the case of herbals and supplements, the format is slightly different. The herbals feature the scientific species and genus, purported indications and other uses, and interactions. Then follows the same format as the generic drugs. There are occasions when there are very few adverse reactions to a specific drug. These drugs are still included, since there is often positive significance in negative findings. Jerome Z. Litt, M.D. May, 2005
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INDEX OF GENERIC AND TRADE NAMES Generic drug names are in bold 3,4’,5-trihydroxystilbene Acanthopanax senticosus acetaminophen
resveratrol siberian ginseng
Anacin-3, Bromo-Seltzer, Darvocet-N, Datril, Excedrin, Liquiprin, Lorcet, Mapap, Neopap, Panadol, Percocet, Percogesic, Phenaphen, Sinutab, Tylenol, Valadol, Vicodin Diamox acetazolamide Achillea millefolium yarrow Aciphex rabeprazole Aclovate corticosteroids Actaea macrotys black cohosh Actaea racemosa black cohosh Actiq fentanyl Activase alteplase Acular ketorolac Adalat nifedipine Humira adalimumab Adant hyaluronic acid Advil ibuprofen Aerobid corticosteroids Aesculus hippocastanum horse chestnut (bark, flower, leaf, seed) Aggrenox aspirin Akineton biperiden Fosamax alendronate Aleve naproxen Alfenta alfentanil Alfenta alfentanil Alka-Seltzer aspirin Allium sativum garlic Axert almotriptan Activase alteplase Hexalen altretamine
ix
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amantadine Amerge amitriptyline amobarbital amyl nitrite Amyl Nitrite Amytal Anacin Anacin-3 anakinra Anamantle HC Anaspaz Android-F Anectine Anestacon Angelica sinensis Ansaid Antilirium Antispaz Anturane Apium carvi Aplegin Apokyn apomorphine Aralen Arava Aricept Arthro-Aid Arthrotec Artistocort ARTZ Ascriptin Aspergum aspirin
Symmetrel naratriptan Elavil, Limbitrol Amytal Amyl Nitrite amyl nitrite amobarbital aspirin acetaminophen Kineret lidocaine hyoscyamine fluoxymesterone succinylcholine lidocaine dong quai flurbiprofen physostigmine dicyclomine sulfinpyrazone caraway l-carnitine apomorphine Apokyn, Uprima chloroquine leflunomide donepezil glucosamine diclofenac corticosteroids hyaluronic acid aspirin aspirin Aggrenox, Alka-Seltzer, Anacin, Ascriptin, Aspergum, Coricidin D, Darvon Compound, Ecotrin, Empirin, Equagesic,
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INDEX OF GENERIC AND TRADE NAMES
Excedrin, Fiorinal, Gelprin, Halfprin, Measurin, Norgesic, Robaxisal, Soma Compound, Talwin Compound, Vanquish Astramorph morphine Tenoretic, Tenormin atenolol Ativan lorazepam Tracrium atracurium Belladenal, Bellergal-S, atropine sulfate Butibel, Donnagel, Donnatal, Donnazyme, Isopto Atropine, Lofene, Logen, Lomanate, Lomotil, Urised Atrovent ipratropium auranofin aurothioglucose Aventyl nortriptyline Avinza morphine Axert almotriptan Imuran azathioprine Azmacort corticosteroids Azulfidine sulfasalazine baclofen Baclofen Bacomine balsalazide Ban-Tuss HC Banflex Barbita Baridium Beclovent Beconase Belladenal Bellergal-S Bemote Bentyl benztropine bepridil bergamot Betaderm Bio-Active Selenium
Baclofen, Lioresal baclofen hydrocodone Colazal hydrocodone orphenadrine phenobarbital phenazopyridine corticosteroids corticosteroids atropine sulfate atropine sulfate dicyclomine dicyclomine Cogentin Vascor Citrus aurantium ssp bergamia corticosteroids selenium
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BioHy biperiden bisoprolol black cohosh
hyaluronic acid Akineton Zebeta, Ziac Actaea macrotys, Actaea racemosa, Cimicifuga racemosa Sanguinaria canadensis bloodroot Caulophyllum thalictroides blue cohosh Botox botulinum toxin (A & B) botulinum toxin Botox, Dysport, Myobloc (A & B) Bromo-Seltzer acetaminophen Parlodel bromocriptine Bucladin-S buclizine Bucladin-S, Vibazine buclizine Butibel atropine sulfate Stadol butorphanol Petasites hybridus, Petasites butterbur officinalis Byclomine dicyclomine Dostinex Coffea arabica, Coffea canephora, Coffea robusta, Cola acuminata, guarana (Paullinia cupana), Thea sinensis, Theobroma cacao Calan verapamil Calcidrine codeine Camellia sinensis green tea Camellia thea green tea Camellia theifera green tea Capex corticosteroids Capsicum annuum, capsicum Capsicum baccatum, Capsicum chinense, Capsicum frutescens, Capsicum pubscens Capsicum annuum capsicum Capsicum baccatum capsicum Capsicum chinense capsicum Capsicum frutescens capsicum Capsicum pubscens capsicum Apium carvi, Carum carvi caraway cabergoline caffeine
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INDEX OF GENERIC AND TRADE NAMES carbamazepine Carbatrol, Epitol, Tegretol Carbatrol carbamazepine carbidopa Cardene nicardipine Cardizem diltiazem Carduus marainum milk thistle Soma carisoprodol Cartia-XT diltiazem Carum carvi caraway Catapres clonidine Caulophyllum blue cohosh thalictroides Celebrex celecoxib Celebrex celecoxib Celestone corticosteroids Celontin methsuximide Cerebyx fosphenytoin Exovac cevimeline Chamomilla recutita, chamomile Matricaria chamomilla, Matricaria recutita Chamomilla recutita chamomile Cheracol codeine Chirocaine levobupivacaine Chitosamine glucosamine Aralen chloroquine chlorzoxazone Paraflex, Parafon Forte DSC chondroitin 4- and 6-sulfate, chondroitin Chondroitin 4-sulfate chondroitin 4- and 6chondroitin sulfate Chondroitin 4-sulfate chondroitin Chrysanthemum feverfew parthenium Tagamet cimetidine Cimicifuga racemosa black cohosh Ciplactin cyproheptadine Ciproral cyproheptadine Nimbex cisatracurium Citrus aurantium ssp bergamot bergamia Librax, Quarzan clidinium Clinoril sulindac Klonopin clonazepam
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xi
Catapres, Combivent Plavix Tranxene hydrocodone Calcidrine, Cheracol, Guaituss AC, Halotussin, Novahistine DH, Nucofed, Robitussin AC, Tussar-2, Tussi-Organidin Mitoquinone, coenzyme q-10 Ubidecarenone, Ubiquinone Coffea arabica caffeine Coffea canephora caffeine Coffea robusta caffeine Cogentin benztropine Cola acuminata caffeine Colazal balsalazide ColBenemid colchicine ColBenemid colchicine Combivent clonidine, ipratropium Symphytum asperum, comfrey Symphytum officinale, Symphytum x uplandicum, Symphytum. peregrinum Commiphora abyssinica myrrh Commiphora erythraea myrrh Commiphora myrrh habessinica Commiphora kataf myrrh Commiphora myrrh madagascariensis Commiphora molmol myrrh Commiphora myrrh myrrh Comtan entacapone Concerta methylphenidate Contergan thalidomide Copaxone glatiramer Cordran corticosteroids Coricidin D aspirin Corigard nadolol Cortef corticosteroids Aclovate, Aerobid, corticosteroids Artistocort, Azmacort, Beclovent, Beconase, Betaderm, Capex, Celestone, clonidine clopidogrel clorazepate Codamine codeine
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INDEX OF GENERIC AND TRADE NAMES
Cordran, Cortef, Cutivate, Cyclocort, Decadron, Delta-Cortef, Deltasone, Depo-Medrol, Dermatop, DesOwen, Dexamethasone, Diprosone, Elocon, Embeline, Flonase, Florinef, Halog, Hytone, Kenalog, Locacorten, Locasalen, Luxiq, Maxidex, Maxitrol, Medrol, Mometason, Nasalide, Nasonex, Olux, Orasone, Poly-Pred, Pred Mild, Pred-G, Prednisolone, Rhinocort, Sicorten, SoluCortef, Solu-Medrol, Synalar, Synemol, Temovate, Topicort, Ultravate, Vancenase, Vanceril, Vasocidin Corzide nadolol Covera-HS verapamil Crataegus laevigata hawthorn (fruit, leaf, flower extract) Crataegus monogyna hawthorn (fruit, leaf, flower extract) Crataegus oxyacantha hawthorn (fruit, leaf, flower extract) Crataegus pentagyna hawthorn (fruit, leaf, flower extract) N-(aminoiminomethyl)-N creatine methyl glycine, N-amidinosarcosine Curcuma aromatica turmeric Curcuma domestica turmeric Curcuma longa turmeric Curcuma xanthorrhiza turmeric Cutivate corticosteroids Flexeril cyclobenzaprine Cyclocort corticosteroids Cylert pemoline cyproheptadine Ciplactin, Ciproral, Nuran, Periactine, Periactinol, Peritol, Sigloton Cytospaz hyoscyamine D.H.E. 45 Dantrium dantrolene Darvocet-N
dihydroergotamine dantrolene Dantrium acetaminophen, propoxyphene
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Darvon propoxyphene Darvon Compound aspirin, propoxyphene Datril acetaminophen Daypro oxaprozin Decadron corticosteroids Delta-Cortef corticosteroids Deltasone corticosteroids Demerol meperidine Depacon valproic acid Depakene valproic acid Depen penicillamine Depo-Medrol corticosteroids Deponit nitroglycerin DermaDeep hyaluronic acid DermaLive hyaluronic acid Dermatop corticosteroids Suprane desflurane DesOwen corticosteroids Desoxyn methamphetamine Detrol tolterodine Harpagophytum devil’s claw procumbens, Harpagophytum zeyheri Dexamethasone corticosteroids Di-Spaz dicyclomine Diamox acetazolamide Dibent dicyclomine Arthrotec, Solaraze Gel, diclofenac Voltaren Antispaz, Bemote, Bentyl, dicyclomine Byclomine, Di-Spaz, Dibent, Neoquess, OrTyl, Spasmoject Dolobid diflunisal D.H.E. 45, Migranal dihydroergotamine Dilacor XR diltiazem Dilantin phenytoin Dilatrate-SR isosorbide dinitrate Dilaudid hydromorphone Diltia-XT diltiazem Cardizem, Cartia-XT, diltiazem Dilacor XR, Diltia-XT, Teczem, Tiazac Diprivan propofol
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INDEX OF GENERIC AND TRADE NAMES Diprosone Distaval divalproex Dolobid Dolophine domperidone donepezil dong quai Donnagel Donnamar Donnatal Donnazyme Dostinex doxacurium Droxia Duoneb Duragesic Duramorph Duratuss DynaCirc Dysport
corticosteroids thalidomide diflunisal methadone Evoxin, Motilium Aricept Angelica sinensis atropine sulfate hyoscyamine atropine sulfate atropine sulfate cabergoline Nuromax hydroxyurea ipratropium fentanyl morphine hydrocodone isradipine botulinum toxin (A & B)
Echinacea angustifola, Echinacea pallida, Echinacea purpurea Echinacea angustifola echinacea Echinacea pallida echinacea Echinacea purpurea echinacea Ecotrin aspirin ED-SPAZ hyoscyamine Enlon, Tensilon edrophonium ELA-Max lidocaine Elavil amitriptyline Eldepryl selegiline Relpax eletriptan Eleutherococcus siberian ginseng senticosus Eligard leuprolide Elmiron pentosan Elocon corticosteroids Embeline corticosteroids Emcyt estramustine EMLA lidocaine Empirin aspirin echinacea
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Enbrel Endocodone enflurane Enlon entacapone Entex HC ephedra
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etanercept oxycodone Ethrane edrophonium Comtan hydrocodone Ephedra equisetina, Ephedra intermedia, Ephedra sinica, Ephedra vulgaris Ephedra equisetina ephedra Ephedra intermedia ephedra Ephedra sinica ephedra Ephedra vulgaris ephedra Epitol carbamazepine Equagesic aspirin Emcyt estramustine Enbrel etanercept Zarontin ethosuximide Peganone ethotoin Ethrane enflurane Lodine etodolac Eucalyptus bicostata, eucalyptus Eucalyptus fruticetorum, Eucalyptus globulus, Eucalyptus odorata, Eucalyptus pauciflora, Eucalyptus polybractea, Eucalyptus smithii Eucalyptus bicostata eucalyptus Eucalyptus fruticetorum eucalyptus Eucalyptus globulus eucalyptus Eucalyptus odorata eucalyptus Eucalyptus pauciflora eucalyptus Eucalyptus polybractea eucalyptus Eucalyptus smithii eucalyptus Oenothera biennis, evening primrose Oenothera muricata, Oenothera purpurata, Oenothera rubricaulis, Oenothera suaveolens Evoxin domperidone Excedrin acetaminophen, aspirin Exovac cevimeline Exsel Shampoo selenium
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INDEX OF GENERIC AND TRADE NAMES
famotidine felbamate Felbatol Feldene fenoprofen fentanyl feverfew
Filipendula ulmaria Fiorinal flavoxate Flexeril Flonase Florinef fluoxymesterone flurbiprofen Forane Fosamax fosphenytoin Frova frovatriptan
Pepcid Felbatol felbamate piroxicam Nalfon Actiq, Duragesic Chrysanthemum parthenium, Pyrethrum parthenium, Tanacetum parthenium meadowsweet aspirin Urispas cyclobenzaprine corticosteroids corticosteroids Android-F, Halotestin Ansaid isoflurane, isoflurane alendronate Cerebyx frovatriptan Frova
Neurontin tiagabine Allium sativum hyoscyamine aspirin papaverine ibuprofen phenazopyridine Zingiber officinale Ginkgo biloba ginkgo biloba Copaxone Arthro-Aid, Chitosamine, Glucosamine sulfate Glucosamine sulfate glucosamine Robinul glycopyrrolate Glycyrrhiza glabra licorice Glycyrrhiza uralensis licorice Myochrysine, Ridaura, gold and gold Solganal compounds gabapentin Gabitril garlic Gastrosed Gelprin Genabid Genpril Geridium ginger ginkgo biloba Ginkgo biloba glatiramer glucosamine
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Zoladex Kytril Camellia sinensis, Camellia thea, Camellia theifera, Thea bohea, Thea sinensis, Thea viridis Guaituss AC codeine Paullinia cupana, Paullinia guarana sorbilis guarana (Paullinia cupana) caffeine goserelin granisetron green tea
Halfprin aspirin Halog corticosteroids Halotestin fluoxymesterone Halotussin codeine Haltran ibuprofen Harpagophytum devil’s claw procumbens Harpagophytum zeyheri devil’s claw hawthorn (fruit, leaf, Crataegus laevigata, Crataegus monogyna, flower extract) Crataegus oxyacantha, Crataegus pentagyna Head & Shoulders selenium Intensive Treatment Dandruff Shampoo Lawsonia alba, Lawsonia henna inermis Hexalen altretamine Hiprex methenamine Aesculus hippocastanum horse chestnut (bark, flower, leaf, seed) Humira adalimumab Hyalgan hyaluronic acid Adant, ARTZ, BioHy, hyaluronic acid DermaDeep, DermaLive, Hyalgan, Hylaform, Hylan G-F 20, Juvederm, Orthovisc, Perlane, Restylane Fine Lines, Supartz Hyco hyoscyamine Hycosol Sl hyoscyamine Hycotuss hydrocodone
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INDEX OF GENERIC AND TRADE NAMES Hydrea hydrocodone
hydroxyurea Bacomine, Ban-Tuss HC, Codamine, Duratuss, Entex HC, Hycotuss, Lortab, Maxidone, Morcomine, Norco, Prolex-DH, Propachem, Ru-Tuss, Tussgen, Tussionex, Tussogest, Vicodin, Vicoprofen, Zydone Dilaudid hydromorphone Plaquenil hydroxychloroquine Droxia, Hydrea, Mylocel hydroxyurea Hylaform hyaluronic acid Hylan G-F 20 hyaluronic acid Anaspaz, Cytospaz, hyoscyamine Donnamar, ED-SPAZ, Gastrosed, Hyco, Hycosol Sl, Hyospaz, IB-Stat, Levbid, Levsin, Levsin/SL, Levsinex, Medispaz, Nulev, Pasmex, Setamine, Urised Hyospaz hyoscyamine Hypericum perforatum St John’s wort Hytone corticosteroids IB-Stat ibuprofen
Imdur Imitrex Imuran Inderal Inderide indomethacin
infliximab Infumorph
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hyoscyamine Advil, Genpril, Haltran, Medipren, Midol 220, Motrin, Nuprin, Pamprin, Profen, Rufen, Trendar, Vicoprofen isosorbide mononitrate sumatriptan azathioprine propranolol propranolol Amuno, Apo-Indomethacin, Durametacin, Imbrilon, Indochron, Indolar SR, Indotec, Nu-Indo, Rhodacine, Vonum Remicade morphine
ipratropium
Atrovent, Combivent, Duoneb isosorbide mononitrate Forane, Forane verapamil atropine sulfate physostigmine scopolamine
Ismo isoflurane Isoptin Isopto Atropine Isopto Eserine Isopto Hyoscine Ophthalmic Isordil isosorbide dinitrate isosorbide mononitrate isradipine Juvederm Kadian kava Kemadrin Kenalog Keppra ketoprofen ketorolac Kevadon Kineret Klavikordal Klonopin Kytril
xv
isosorbide dinitrate Dilatrate-SR, Isordil, Sorbitrate Imdur, Ismo, Monoket DynaCirc hyaluronic acid morphine Piper methysticum procyclidine corticosteroids levetiracetam Orudis, Oruvail Acular, Toradol thalidomide anakinra nitroglycerin clonazepam granisetron
L-2-amino-3-(indole-3yl) tryptophan propionic acid L-Carnipure l-carnitine Aplegin, L-Carnipure l-carnitine Lamictal lamotrigine Lamictal lamotrigine Lavandula angustifolia lavender Lavandula dentata lavender Lavandula spica lavender Lavandula vera lavender Lavandula angustifolia, lavender Lavandula dentata, Lavandula spica, Lavandula vera
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INDEX OF GENERIC AND TRADE NAMES
Lawsonia alba Lawsonia inermis leflunomide leucovorin Leucovorin leuprolide Levbid levetiracetam levobupivacaine levodopa Levsin Levsin/SL Levsinex Librax licorice
henna henna Arava Leucovorin leucovorin Eligard, Lupron, Viadur hyoscyamine Keppra Chirocaine Sinemet hyoscyamine hyoscyamine hyoscyamine clidinium Glycyrrhiza glabra, Glycyrrhiza uralensis Anamantle HC, Anestacon, lidocaine ELA-Max, EMLA, Lidoderm, Xylocaine Lidoderm lidocaine Limbitrol amitriptyline Linum usitatissimum linseed Linum usitatissimum linseed Lioresal baclofen Liquiprin acetaminophen Locacorten corticosteroids Locasalen corticosteroids Lodine etodolac Lofene atropine sulfate Logen atropine sulfate Lomanate atropine sulfate Lomotil atropine sulfate Ativan lorazepam Lorcet acetaminophen Lortab hydrocodone Luminal phenobarbital Lupron leuprolide Luxiq corticosteroids Mandelamine Mapap Matricaria chamomilla Matricaria recutita Maxalt
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methenamine acetaminophen chamomile chamomile rizatriptan
Maxidex Maxidone Maxitrol mazindol
corticosteroids hydrocodone corticosteroids Diestet, Liofindol, Solucaps, Teronac meadowsweet Filipendula ulmaria, Spiraea ulmaria Measurin aspirin Mebaral mephobarbital Meclofenamate meclofenamate Meclofenamate meclofenamate Medipren ibuprofen Medispaz hyoscyamine Medrol corticosteroids Ponstel mefenamic acid N-acetyl-5melatonin methoxytryptamine Mobic meloxicam Mentha piperita peppermint Demerol meperidine Mesantoin mephenytoin Mebaral mephobarbital Mesantoin mephenytoin Metadate CD methylphenidate Skelaxin metaxalone Dolophine methadone Desoxyn methamphetamine Vagantin methantheline Hiprex, Mandelamine, methenamine Prosed, Urised, Uroqid Robaxin methocarbamol Rheumatrex methotrexate Penthrane methoxyflurane Celontin methsuximide Methylin methylphenidate methylphenidate Concerta, Metadate CD, Methylin, Ritalin Sansert methysergide Midol 220 ibuprofen Migranal dihydroergotamine Carduus marainum, Silibum milk thistle marianum Minitran nitroglycerin Mirapex pramipexole
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INDEX OF GENERIC AND TRADE NAMES Phoradendron flavescens, Phoradendron leucarpum, Phoradendron macrophyllum, Phoradendron rubrum, Phoradendron serotinum, Phoradendron tomentosum, Viscum album Mitoquinone coenzyme q-10 Mobic meloxicam Provigil modafinil Mometason corticosteroids Mono-Gesic salsalate Monoket isosorbide mononitrate Morcomine hydrocodone Astramorph, Avinza, morphine Duramorph, Infumorph, Kadian, MS Contin, MS/S, MSIR Oral, OMS Oral, Oramorph SR, RMS, Roxanol Motilium domperidone Motrin ibuprofen MS Contin morphine MS/S morphine MSIR Oral morphine Mylocel hydroxyurea Myobloc botulinum toxin (A & B) Myochrysine gold and gold compounds Commiphora abyssinica, myrrh Commiphora erythraea, Commiphora habessinica, Commiphora kataf, Commiphora madagascariensis, Commiphora molmol, Commiphora myrrh Mysoline primidone
mistletoe
N-(aminoiminomethyl)N methyl glycine N-acetyl-5methoxytryptamine N-amidinosarcosine nabumetone nadolol nalbuphine
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creatine melatonin creatine Relafen Corigard, Corzide Nubain
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Nalfon fenoprofen Naprosyn naproxen Aleve, Naprosyn naproxen Amerge naratriptan Nasalide corticosteroids Nasonex corticosteroids Neopap acetaminophen Neoquess dicyclomine Neurontin gabapentin Cardene nicardipine Adalat, Procardia nifedipine Nimbex cisatracurium Niong nitroglycerin Nitrocap nitroglycerin Nitrocine nitroglycerin Nitrodisc nitroglycerin Nitrodur nitroglycerin nitroglycerin Deponit, Klavikordal, Minitran, Niong, Nitrocap, Nitrocine, Nitrodisc, Nitrodur, Nitroglyn, Nitroject, Nitrol, Nitrolingual, Nitronet, Nitrong, Nitrospan, Nitrostat, Transderm-Nitro, Tridil Nitroglyn nitroglycerin Nitroject nitroglycerin Nitrol nitroglycerin Nitrolingual nitroglycerin Nitronet nitroglycerin Nitrong nitroglycerin Nitrospan nitroglycerin Nitrostat nitroglycerin Norco hydrocodone Norcuron vecuronium Norflex orphenadrine Norgesic aspirin Aventyl, Pamelor nortriptyline Novahistine DH codeine Nubain nalbuphine Nucofed codeine Nulev hyoscyamine Nuprin ibuprofen Nuran cyproheptadine Nuromax doxacurium
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INDEX OF GENERIC AND TRADE NAMES
Oenothera biennis evening primrose Oenothera muricata evening primrose Oenothera purpurata evening primrose Oenothera rubricaulis evening primrose Oenothera suaveolens evening primrose Olux corticosteroids Prilosec omeprazole OMS Oral morphine Zofran ondansetron Oramorph SR morphine Orasone corticosteroids Banflex, Norflex orphenadrine Orthovisc hyaluronic acid OrTyl dicyclomine Orudis ketoprofen Oruvail ketoprofen Daypro oxaprozin Serax oxazepam Trileptal oxcarbazepine Endocodone, OxyContin, oxycodone OxyIR, Percocet, Roxicodone, Tylox OxyContin oxycodone OxyIR oxycodone Pamelor Pamprin Panadol pancuronium
nortriptyline ibuprofen acetaminophen Alpax, Bromurex, Curon-B, Panconium, Panslan Protonix pantoprazole Genabid, Pavabid, Pavatine papaverine Paraflex chlorzoxazone Parafon Forte DSC chlorzoxazone paramethadione Parlodel bromocriptine Pasmex hyoscyamine Paullinia cupana guarana Paullinia sorbilis guarana Pausinystalia yohimbe yohimbine Pavabid papaverine Pavatine papaverine Peganone ethotoin
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Cylert Depen Talwin methoxyflurane Medinox Mono, Mintal, Nova Rectal, Pentobarbitone, Prodromol, Sombutol Elmiron pentosan Pepcid famotidine Mentha piperita peppermint Percocet acetaminophen, oxycodone Percogesic acetaminophen Permax pergolide Periactine cyproheptadine Periactinol cyproheptadine Peritol cyproheptadine Perlane hyaluronic acid Permax pergolide Petasites hybridus butterbur Petasites officinalis butterbur Phellodendron amurense, phellodendron Phellodendron chinense, Phellodendron wilsonii Phellodendron phellodendron amurense Phellodendron chinense phellodendron Phellodendron wilsonii phellodendron Phenaphen acetaminophen Baridium, Geridium, phenazopyridine Prodium, Pyridiate, Pyridium Barbita, Luminal, Solfoton phenobarbital phensuximide Phenytek phenytoin Dilantin, Phenytek phenytoin Phoradendron mistletoe flavescens Phoradendron mistletoe leucarpum Phoradendron mistletoe macrophyllum Phoradendron rubrum mistletoe pemoline penicillamine pentazocine Penthrane pentobarbital
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INDEX OF GENERIC AND TRADE NAMES Phoradendron mistletoe serotinum Phoradendron mistletoe tomentosum Antilirium, Isopto Eserine physostigmine pipecuronium Piper methysticum kava Feldene piroxicam Plaquenil hydroxychloroquine Plavix clopidogrel Poly-Pred corticosteroids Ponstel mefenamic acid Mirapex pramipexole Pred Mild corticosteroids Pred-G corticosteroids Prednisolone corticosteroids Prilosec omeprazole Mysoline primidone Procardia nifedipine Kemadrin procyclidine Prodium phenazopyridine Profen ibuprofen Prolex-DH hydrocodone Propachem hydrocodone Propantheline propantheline Propantheline propantheline Diprivan propofol Darvocet-N, Darvon, propoxyphene Darvon Compound Inderal, Inderide propranolol Prosed methenamine Protonix pantoprazole Provigil modafinil Pyrethrum parthenium feverfew Pyridiate phenazopyridine Pyridium phenazopyridine Quarzan quinupristin/dalfopristin rabeprazole ranitidine rapacuronium Raplon
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clidinium Synercid Aciphex Zantac Raplon rapacuronium
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Trifolium pratense red clover Relafen nabumetone Relpax eletriptan Remicade infliximab Requip ropinirole Restoril temazepam Restylane Fine Lines hyaluronic acid 3,4’,5-trihydroxystilbene, resveratrol trans-resveratrol-3-Oglucuronide, transresveratrol-3-sulfate Retavase reteplase Retavase reteplase Rheumatrex methotrexate Rhinocort corticosteroids Ridaura gold and gold compounds Rilutek riluzole Rilutek riluzole Ritalin methylphenidate Maxalt rizatriptan RMS morphine Robaxin methocarbamol Robaxisal aspirin Robinul glycopyrrolate Robitussin AC codeine Vioxx rofecoxib Requip ropinirole Roxanol morphine Roxicodone oxycodone Ru-Tuss hydrocodone Ruta chalepensis, Ruta rue corsica, Ruta graveolens, Ruta montana Rufen ibuprofen Ruta chalepensis rue Ruta corsica rue Ruta graveolens rue Ruta montana rue Sabal serrulata Sabril Salflex Salix alba Salix fragilis
saw palmetto vigabatrin salsalate willow bark willow bark
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INDEX OF GENERIC AND TRADE NAMES
Salix purpurea willow bark Mono-Gesic, Salflex salsalate Sanguinaria canadensis bloodroot Sansert methysergide sarsaparilla Smilax aristolochiaefolia, Smilax febrifuga, Smilax glabra, Smilax japicanga, Smilax officinalis, Smilax ornata, Smilax regelii, Smilax rotundifolia Sabal serrulata, Serenoa saw palmetto repens, Serenoa serrulata Scopase scopolamine scopolamine Isopto Hyoscine Ophthalmic, Scopase, Transderm-Scop Patch Eldepryl selegiline Bio-Active Selenium, Exsel selenium Shampoo, Head & Shoulders Intensive Treatment Dandruff Shampoo, SelenoMax, Selsun Blue, Selsun Shampoo, Vpak51 SelenoMax selenium Selsun Blue selenium Selsun Shampoo selenium Serax oxazepam Serenoa repens saw palmetto Serenoa serrulata saw palmetto Setamine hyoscyamine siberian ginseng Acanthopanax senticosus, Eleutherococcus senticosus Sicorten corticosteroids Sigloton cyproheptadine Silibum marianum milk thistle Sinemet levodopa Sinutab acetaminophen Skelaxin metaxalone Smilax aristolochiaefolia sarsaparilla Smilax febrifuga sarsaparilla Smilax glabra sarsaparilla Smilax japicanga sarsaparilla Smilax officinalis sarsaparilla Smilax ornata sarsaparilla Smilax regelii sarsaparilla
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Smilax rotundifolia sarsaparilla Xyrem sodium oxybate Solaraze Gel diclofenac Solfoton phenobarbital Solganal gold and gold compounds Vesicare solifenacin Solu-Cortef corticosteroids Solu-Medrol corticosteroids Soma carisoprodol Soma Compound aspirin Sonata zaleplon Sorbitrate isosorbide dinitrate Spasmoject dicyclomine Spiraea ulmaria meadowsweet Spiriva tiotropium Hypericum perforatum St John’s wort Stadol butorphanol Anectine succinylcholine Sufenta sufentanil Sufenta sufentanil Azulfidine sulfasalazine Anturane sulfinpyrazone Clinoril sulindac Imitrex sumatriptan Supartz hyaluronic acid Suprane desflurane Symmetrel amantadine Symphytum asperum comfrey Symphytum officinale comfrey Symphytum x comfrey uplandicum Symphytum. peregrinum comfrey Synalar corticosteroids Synemol corticosteroids Synercid quinupristin/dalfopristin Tagamet Talwin Talwin Compound Tanacetum parthenium Tarka Tasmar Teczem Tegretol
cimetidine pentazocine aspirin feverfew verapamil tolcapone diltiazem carbamazepine
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INDEX OF GENERIC AND TRADE NAMES Restoril, Temazepam temazepam corticosteroids atenolol atenolol edrophonium Contergan, Distaval, Kevadon, Thalomid Thalomid thalidomide Thea bohea green tea Thea sinensis caffeine, green tea Thea viridis green tea Theobroma cacao caffeine Thiopental thiopental Thiopental thiopental Gabitril tiagabine Tiazac diltiazem Spiriva tiotropium Zanaflex tizanidine Tonocard tocainide Tasmar tolcapone Tolectin tolmetin Tolectin tolmetin Detrol tolterodine Tonocard tocainide Topamax topiramate Topicort corticosteroids Topamax topiramate Toradol ketorolac Tracrium atracurium Ultracet, Ultram tramadol trans-resveratrol-3-Oresveratrol glucuronide trans-resveratrol-3resveratrol sulfate Transderm-Nitro nitroglycerin Transderm-Scop Patch scopolamine Tranxene clorazepate Trendar ibuprofen Tridil nitroglycerin Tridione trimethadione Trifolium pratense red clover trihexyphenidyl Acamed, Aparkane, Bentex, Hexinal, Hipokinon, temazepam Temazepam Temovate Tenoretic Tenormin Tensilon thalidomide
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Trileptal trimethadione tryptophan turmeric
Tussar-2 Tussgen Tussi-Organidin Tussionex Tussogest Tylenol Tylox Ubidecarenone Ubiquinone Ultracet Ultram Ultravate Uprima Urised
Urispas Uroqid Valadol valproic acid Vancenase Vanceril Vanquish Vascor Vasocidin vecuronium verapamil Verelan Vesicare Viadur Vibazine
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Parkines, Partane, Tridyl, Trihexy, Trihexyphen oxcarbazepine Tridione L-2-amino-3-(indole-3yl) propionic acid Curcuma aromatica, Curcuma domestica, Curcuma longa, Curcuma xanthorrhiza codeine hydrocodone codeine hydrocodone hydrocodone acetaminophen oxycodone coenzyme q-10 coenzyme q-10 tramadol tramadol corticosteroids apomorphine atropine sulfate, hyoscyamine, methenamine flavoxate methenamine acetaminophen Depacon, Depakene corticosteroids corticosteroids aspirin bepridil corticosteroids Norcuron Calan, Covera-HS, Isoptin, Tarka, Verelan verapamil solifenacin leuprolide buclizine
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INDEX OF GENERIC AND TRADE NAMES
Vicodin Vicoprofen vigabatrin Vioxx Viscum album Voltaren Vpak51 willow bark
acetaminophen, hydrocodone hydrocodone, ibuprofen Sabril rofecoxib mistletoe diclofenac selenium Salix alba, Salix fragilis, Salix purpurea
Xylocaine Xyrem yarrow yohimbine
lidocaine sodium oxybate Achillea millefolium Pausinystalia yohimbe
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zaleplon Zanaflex Zantac Zarontin Zebeta Ziac Zingiber officinale Zofran Zoladex zolmitriptan Zomig Zonegran zonisamide Zydone
Sonata tizanidine ranitidine ethosuximide bisoprolol bisoprolol ginger ondansetron goserelin Zomig zolmitriptan zonisamide Zonegran hydrocodone
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CLASSES OF DRUGS topiramate trimethadione valproic acid vigabatrin zonisamide
Anticholinergics biperiden buclizine clidinium dicyclomine glycopyrrolate hyoscyamine ipratropium methantheline procyclidine propantheline scopolamine tiotropium tolterodine trihexyphenidyl
Antimigraine amitriptyline frovatriptan naratriptan nicardipine nifedipine rizatriptan sumatriptan zolmitriptan
Anticonvulsants acetazolamide amobarbital carbamazepine clonazepam ethosuximide ethotoin fosphenytoin gabapentin lamotrigine levetiracetam lorazepam mephenytoin mephobarbital methsuximide oxazepam oxcarbazepine paramethadione pentobarbital phensuximide phenytoin primidone thiopental tiagabine
Anti-Parkinsonian amantadine apomorphine benztropine biperiden bromocriptine entacapone levodopa pergolide pramipexole procyclidine ropinirole selegiline tolcapone trihexyphenidyl Neuromuscular blockers atracurium botulinum toxin (A & B) cisatracurium doxacurium edrophonium vecuronium
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ACETAMINOPHEN
ACETAMINOPHEN Synonyms: APAP; paracetamol Trade names: Anacin-3 (Wyeth); Bromo-Seltzer; Darvocet-N (aaiPharma); Datril; Excedrin (Bristol-Myers Squibb); Liquiprin; Lorcet (Forest); Mapap; Neopap; Panadol (GSK); Percocet (Endo); Percogesic; Phenaphen; Sinutab; Tylenol (Ortho-McNeil); Valadol; Vicodin (Abbott) Other common trade names: Abenol; Anaflon; Ben-U-Ron; Doliprane; Geluprane; Panadol Indications: Pain, fever Category: Non-narcotic antipyretic analgesic Half-life: 1–3 hours Clinically important, potentially hazardous interactions with: alcohol, cholestyramine, didanosine, dong quai, melatonin Note: Acetaminophen is the active metabolite of phenacetin Reactions Skin Acute generalized exanthematous pustulosis (AGEP) [6] Angioedema (
