MEDICAL INTEllIGENCE UNIT
Hematopoietic Stem Cell Development Isabelle Godin, Ph.D. Hemaropoiese et Cellules Souches INSERM U362 Institut Gustave Roussy Villejuif, France
Ana Cumano, M.D. Unite du Developpernent des Lymphocytes INSERMU668 Institut Pasteur Paris, France
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lIEMAroPOIETIC
STEM CELL DEVELOPMENT
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Hematopoietic Stem CeO Development, edited by Isabelle Godin and Ana Cumano, Landes 1 K1uwer dual imprint 1 Landes series: Medical Intelligence Unit ISBN: 0-306-47872-2 While rhe aurhors, editors and publisher believe rhat drug selection and dosage and rhe specifications and usage of equipment and devices, as set forth in rhis book, are in accord wirh current recommendations and practice at rhe time of publication, rhey make no warranty, expressed or implied , wirh respect to material described in rhis book. In view of the ongoing research, equipment development, changes in governmental regulations and the rapid accumulation of information relating to the biomedical sciences, the reader is urged to carefullyreviewand evaluate the information provided herein.
Library of Congress Cataloging-in-Publication Data Hematopoietic stern cell development 1 [edited by) Isabelle Godin, Ana Cumano, p. ; ern. -- (Medical intelligence unit) Includes bibliographical references and index. ISBN 0-306-47872-2 1. Hematopoietic stern cells. 2. Hematopoiesis . 1. Godin, Isabelle. II. Cumano, Ana. III. Series: Medical intelligence unit (Unnumbered : 2003) [DNLM: 1. Hemaropoiesis-sphysiology . 2. Hematopoietic Stem Cells --physiology. 3. Hematopoiesis --genetics. WH 380 H48692 2006) QP92.H4533 2006 612.4 '1--dc22 2005033933
rr:================== CONTENTS =================il Preface 1. Ventral and Dorsal Contributions to Hematopoiesis in Xenopus
Aldo Ciau-Uitz; Maggie Walmsley and Roger Patient Hematopoietic Organs in Xenopus Origins of Hematopoietic Cells in Xenopus Development of Hematopoietic Cells in Association with Endothelial Cells in Xenopus Embryonic Signals Involved in Hematopoietic Development in Xenopus 2. Genetic Dissection of Hematopoiesis Using the Zebrafish
xi
1 2 3 7 9 14
RebeccaA. Wingert and Leonard I Zon Zebrafish Hematopoiesis Zebrafish Genetics and Hematopoietic Mutants Mesoderm Patterning Mutants Hematopoietic Stem Cell Mutants Committed Progenitor Mutants Differentiation and Proliferation Mutants Hypochromic Blood Mutants Photosensitive Mutants Future Directions
14 16 17 18 21 22 23 24 25
3. Extra- and Intraembryonic HSC Commitment in the Avian Model ..... 32
Thierry ]affredo, Karine Bollerot, Krisztina Minko, Rodolpbe Gautier, Stephane Romero and cecile Drevon The HSC That Colonise the Hematopoietic Organs Have an Extrinsic Origin The Discoveryof an Intraembryonic Hematopoietic Site Gastrulation and Patterning of the Mesoderm Role of the Endod erm Hemangioblast and the Hemogen ic Endothelium Dual Origin of Aortic ECs Manipulating the AngiopoieticlHemangiopoietic Commitment The Allantois, a Later Source of HSC Colonizing the Bone Marrow 4. Avian Lymphopoiesis and Transcriptional Control of Hematopoietic Stem Cell Differentiation
32 32 33 37 38 41 41 42 46
[ussi Liippo and OlliLassila Hemangioblasts Transcription Factors and Early Hematopoiesis Adoption of the Lymphoid Fate Molecular Control ofT Lymphopoiesis Molecular Control ofB Lymphopoiesis The Ikaros Family of Transcription Factors Contribution ofIkaros to the Hematopoietic Compartments Ikaros and Hematopoietic Stem Cells
47 47 50 51 52 53 54 54
Ikaros and Thymocyte Development Ikaros: A Threshold for T Cell Function Aiolos: Setting Brakes for B Cells Ikaros and Aiolos Running the Lympho id Chromatin Modifying Machinery The Ikaros Family in Avian Lymphohematopoiesis 5. Yolk Sac Development in Mice
54 55 55 56 58 62
james Palis Gastrulation and Yolk Sac Formation Blood Island Formation Hemangioblast Primitive Erythropo iesis D evelopment of Unipotential Hematopoietic Progenitors Development of Multipotential Myeloid Progenitors Development of Hem atopoiet ic Stem Cells Summary: A Model of Yolk Sac Hematopoiesis
62 63 64 65 65 66 66 67
6. Long-Term Reconstituting Hematopoietic Stem Cell Capacity in the Embryo
72
Mervin C. Yoder General Principles of Hematopoiet ic Stem Cell Emergence during Ontogeny Emergence of Hematopoietic Stem Cells in the Yolk Sac Hematopoietic Stem Cell Ontogeny in the Embryo Proper 7. The Endothelium: The Cradle of Definitive Hematopoiesis?
73 73 75 80
Katrin Ottersbachand Elaine Dzierzae The Emergence of Definitive HSCs: Origin and Regulation H emangioblast or Hemogenic Endothelial Cells? 8. Endothelial and Hematopoietic Cells in the Intraembryonic Compartment
81 83 92
Fumio Arai and Tosbio Suda Development ofYasculature Development ofHCs Regulation of Hema topo iesis H emangioblasts: Common Progenitors ofHCs and ECs Interact ion between HSCs and ECs 9. Origin and Fate of Hematopoietic Precursors in the Early Mouse Embryo
92 98 99 100 102 108
julien Yuan Bertrand, Alexandra Manaia, jeanne Van Celst, Ana Camano and Isabelle Godin Extra- and Intraembryonic Contribution to Hematopoietic Development Intraembryonic Hematopoiesis: To the Precise Origin ofHSC
109 114
10. Hematopoietic Development in Drosophila: A Parallel with Vertebrates
Marie Meister and Shubha Govind Drosophila Hemocyte Types and Their Functions Hematopoietic Development Genetic Control of Hematopoiesis Hormonal Control of Hematopoiesis Drosophila as a Model System for Understanding Mammalian Hematopoiesis 11. Intraembryonic Development of Hematopoietic Stem Cells during Human Ontogeny: Expression Analysis
124 125 126 128 135 136 142
Caroline Marshall Techniques Analysis of Gene Expression Patterns in the Human AGM Expression of Receptors and Ligands in the Human AGM Expression of Transcription Factors in the AGM Expression of Cell Adhesion Molecules in the AGM Environmental Expression Patterns in the AGM Comparison ofAGM and Fetal Liver Expression Patterns 12. Gene and Cell Therapy Involving Hematopoietic Stem Cell
143 143 144 145 146 147 149 154
Isabelle Andre-Schmutz andMarina Cavazzana-Calvo Hematopoietic Stem Cell Transplantation (HSCn: Generalities Gene Therapy Severe Combined Immunodeficiency Disease Fanconi Anemia Chronic Granulomatous Disease Hemoglobinopathies Conclusions and Perspectives in the Use of HSC for Regenerative Medicine Index
154 160 160 162 163 164 165 175
~============ EDITORS ===================il
Isabelle Godin Hematopofese et Cellules Souches
INSERM U362 Institut Gustave Roussy Vtllejuif, France Email:
[email protected] Chapter 9
AnaCumano Unite du Developpement des Lymphocytes INSERMU668 Institut Pasteur Paris, France Email:
[email protected] Chapter 9
~~~~CONTroBUTORS~~~~ Isabelle Andre -Schmutz Laboratoire de Therapie Cellulaire et Genetique INSERM U 429 Hopiral Necker Enfants Malades Paris, France Email:
[email protected] Chapter 12 FumioArai Department of Cell Differentiation The Sakaguchi Laboratory of Developmental Biology School of Medicine Keio Universiry Shinjuku-ku, Tokyo, Japan Chapter 8
Julien Yuan Benrand Unite du Developpement des Lymphocytes INSERM U668 Institut Pasteur Paris, France
and Division of BiologicaI Sciences University of California, San Diego La Jolla, California, U .S.A.
Chapter 9 Karine Bolleror UMR7622 UPMC Paris VI Paris, France
Chapter 3 Marina Cavazzana-Calvo Laboratoire de Therapie Cellulaire er Generique INSERM U 429 Hopital Necker Enfants Malades Paris, France Email :
[email protected] Chapter 13
Aldo Ciau-Uitz Institute of Genetics University of Nottingham Queen's Medical Centre Nottingham, U.K Chapter 1 Cecile Drevon Universite des Sciences et Technologies de Lille Laborato ire de Biologie du Develop,pement Villeneuve d Ascq, France Chapter 3 Elaine Dzierzak Department of Cell Biology and Genetics Erasmus University Medical Center Rotterdam, The Netherlands Email:
[email protected] Chapter 7 Rodolphe Gautier UPMC Paris VI Paris, France Chapter 3 Shubha Govind Department of Biology City College of New York and Graduate School Un iversity Center of the City University of New York New York, New York, U.SA Chapter 10 Thierry ]affredo UMR7622 UPMC Paris VI Paris, France Email:
[email protected] Chapter 3
oHi Lassila Department of Medical Microbiology Turku Graduate School of Biomedical Sciences University of Turku Turku, Finland Email:
[email protected] Chapter 4 ]ussi Liippo Department of Medical Microbiology Turku Graduate School of Biomedical Sciences University ofTurku Turku, Finland Email:
[email protected] Chapter 4 Alexandra Manaia Unite INSERM U362 Institut Gustave Roussy Villejuif, France and European Learning Laboratory for Life Sciences EMBL Heidelberg, Germany Email:
[email protected] Chapter 9 Caroline Marshall Molecular Immunology Unit Institute of Child Health London, U.K Email:
[email protected] Chapter 11 Marie Meister UPR 9022 du CNRS IBMC Srrasbourg, France Chapter 10 Krisztina Minko Department of Human Morphology and Biology Semmelweis University Budapest, Hungary Chapter 3
Katrin Ottersbach Department of Cell Biology and Genetics Erasmus University Medical Center Rotterdam, The Netherlands
Jeanne Van Celst Unite INSERM U362 Instirut Gustave Roussy Villejuif France
Chapter 9
Chapter 7 James Palis Department of Pediatrics Cancer Center Center of Human Genetics and Molecular Pediatric Disease University of Rochester School of Medicine and Dentistty Rochester, New York, U.S.A. Email:
[email protected] Chapter 5 Roger Patient The Weatherhall Institute of Molecular Medicine MRC Molecular Haernatology Unit University of Oxford John Radcliffe Hospital Headington, Oxford, U.I
