Clinical Pharmacology, 10th edition

'i\t)d I w'ill usc n:ghnt'n.S for the benefit of th e ill ln accordance with my abili[t and my jud$.,>cment.' Hippocrates' Oath ~alley used to howe a moreequitab1econlrad in (ancient} Egypt: fo r the first three days, the d octor too k o n the

patient at the patient's risk a.od peril: when the three days we.re up, the risks c that arc innoce nt are permissible, a nd those that may do good are obllgatol'y.' ' Men w ho have excmh<e f.aJth in the ir theories or id eas are llOt o nly ill prepared for making discoveries; they rnakc \'tty poorobscrvalions .. . they can M:e in (their) results onJy a confirm:\rion of their the~>lY ... ·Ill is is what made t.LS sa)' that we ITI\.tSC never make experimems to confirm our ideas, but simply to contro l them: ' Medicine is d estined to get away fro m empiricism little by little: like all o ther sdenres, il will get away by the scientific method.'

'Considered in itse.lf. the experimental method is nothing but reasoning by who~ help we methodically sub· mit our ideas to experiellce - the experien)' may become n~~ry or approprtnlc. R~ders art n P•~~dtd ( i) on prottdu.m ft"~htrt'd or (ii) by lh< fiWlu.&cn.n olt-ach produa to be: ~minisund,. to vm:(y dlf: too:Mn · rnr-n~cd dose o r formu l.a. the: rnahod and d uration or ad> mlnhtnulon. :lnd tamr.•lndlc::uions. It Ia the r~lhlll ty of dw prnailiot1('1, tf'l yln.g on thl'ir OWt'l t:.Xpl.'fie:n~ an4 lm owk. of tht" j)Ji i proollutiOfti. To lh~t fullot mem oft~ lAW$ nrithtr thor P\lblisher not the l..duofl/'-ud~oq :I)IIUII'k llllY liability fur :~ny 1njury and/or damage lo IX'~ or propcn~· ari.,.h,f:. QUl or rdated tO an)' u:.c o ( th~ matCTI.,) containOSt"~ and iL'I plan. Tl)is book is about the scieo.tWt basis atld ~)f'3 Ctic(' of d rug therapy. It addrn.w.s medk~1 l smdent.s and doctors in J>anicular. bul also anyone concerned with evidence-based drug therapy and prescribing. The S to be swall o~>~t-d. and some few to be chewed and diboested.' l)erhap.s ele-ments or each anbrooke's

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