Adolescent Medicine: Requisites (Requisites in Pediatrics)

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lib r ary of Co n g ress Ca ta lo g tn g-In -P u b l lcatt o n Data Adol escent med ici ne / [e d ite d by) Ga il B. Slap . p. ; e m , - (TIll' requisites in ped tatr tcs) In cl ud e s bibli ograp hi ca l re fe re nces and inde x . ISBN 9iH - O -:~ 2 :~ - () ..j n7 :H I (al k. paper) l. Adolescent med ici ne . I. Sla p , Ga il B. II. Se r ie s. ID~L.\ I : I. Adolescent ~kdidne . 2 . Ad ole sc ent Development. j. Adolescent Psyc ho lo gy. WS 460 A 2;W ,j 200 MI R,ISSO.A';') 74 200M 6 16,OOHjS- dc22

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Pr int e d in the Unnc d Sta te s o f America. La st diRit is the print number: 9

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TlJis book is dedicated to lifelong students of adolescent m edicine, regard less of teoet. career phase, or years OJ expe rience.

Contributors

Raouf S. Amin, MD, ABSM Professor of Pediatrics University of Cincinnati College of Medicine Director, Division of Pulmonary Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio

Maria T. Britto, MD, MPH Professor of Pediatrics University of Cincinnati College of Medicine Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio

Drew H. Barzman, MD Assistant Professor of Psychiatry and Pediatrics University of Cincinnati College of Medicine Division of Child and Adolescent Psychiatry Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio

Kelly C. Byars, PsyD, CBSM Associate Professor of Pediatrics University of Cincinnati College of Medicine Director, Behavioral Sleep Medicine Program Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio

Frank M. Biro, MD Professor of Pediatrics and Internal Medicine University of Cincinnati College of Medicine Director, Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio

Marina Catallozzi, MD Assistant Professor of Clinical Pediatrics and Population and Family Health Columbia University College of Physicians and Surgeons and the Mailman School of Public Health Director, Adolescent Medicine Consult Service Medical Director, Lang Youth Medical Program Columbia University Medical Center New York, New York

Paula K. Braverman, MD Professor of Pediatrics University of Cincinnati College of Medicine Director of Community Programs Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Lesley L. Breech, MD Associate Professor of Pediatrics and Obstetrics/ Gynecology University of Cincinnati College of Medicine Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio

Paul R. Crosby, MD Northern Michigan Psychiatric Services Traverse City, Michigan Stephen R. Daniels, MD, PhD Professor and L. Joseph Butterfield Chair of Pediatrics University of Colorado School of Medicine Pediatrician in Chief The Children’s Hospital Denver, Colorado

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Contributors

Lorah D. Dorn, PhD Professor of Pediatrics University of Cincinnati College of Medicine Director of Research, Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio James R. Ebert, MD, MBA Associate Professor of Pediatrics and Community Health Wright State University Boonshoft School of Medicine Kettering, Ohio Carol Engel, MD Assistant Professor of Psychiatry and Pediatrics University of Cincinnati College of Medicine Division of Child and Adolescent Psychiatry Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Reginald S. Ewing III, MD Medical Department U.S. Naval Academy Annapolis, Maryland Kenneth R. Ginsburg, MD, MEd Associate Professor of Pediatrics University of Pennsylvania School of Medicine Craig-Dalsimer Division of Adolescent Medicine The Children’s Hospital of Philadelphia Philadelphia, Pennsylvania Albert C. Hergenroeder, MD Professor of Pediatrics, Baylor College of Medicine Chief,  Adolescent Medicine and Sports Medicine Section Texas Children’s Hospital Houston,Texas Andrew D. Hershey, MD, PhD Professor of Pediatrics and Neurology University of Cincinnati College of Medicine Director, Headache Center Associate Director, Neurology Research Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Richard B. Heyman, MD Suburban Pediatric Associates Cincinnati, Ohio

Paula J. Adams Hillard, MD Professor of Obstetrics and Gynecology Stanford University Medical Center Department of Obstetrics and Gynecology Stanford, California Jill S. Huppert, MD, MPH Assistant Professor of Pediatrics and Obstetrics and Gynecology University of Cincinnati College of Medicine Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Thomas H. Inge, MD, PhD, FACS, FAAP Assistant Professor of Surgery University of Cincinnati College of Medicine Pediatric Surgical Director Comprehensive Weight Management Center Division of Pediatric General and Thoracic Surgery Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Marielle A. Kabbouche, MD Assistant Professor of Child Neurology University of Cincinnati College of Medicine Division of Neurology Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Jessica A. Kahn, MD, MPH Associate Professor of Pediatrics University of Cincinnati College of Medicine Director of Research Training Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Velissarios Karacostas, MD, PhD Assistant Professor of Psychiatry and Pediatrics University of Cincinnati College of Medicine Division of Child and Adolescent Psychiatry Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Linda M. Kollar, RN, MSN Director of Clinical Services, Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio



Christopher E. Kraus, JD, MTS Adolescent Advocacy Manager, Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Corinne Lehmann, MD, MEd Associate Professor of Pediatrics and Internal Medicine University of Cincinnati College of Medicine Director of Resident/Medical Student Training Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Laurie A. P. Mitan, MD Associate Professor of Pediatrics University of Cincinnati College of Medicine Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Tanya Kowalczyk Mullins, MD Research Fellow Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Donald P. Orr, MD Professor of Pediatrics and Nursing Indiana University Medical Center Director, Section of Adolescent Medicine Riley Hospital for Children Indianapolis, Indiana Joseph L. Rauh, MD Emeritus Professor of Pediatrics University of Cincinnati College of Medicine Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Giselle Schneider, MD, MS Staff Physician Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Gail B. Slap, MD, MS Professor of Pediatrics and Medicine University of Pennsylvania School of Medicine Director of Fellowship Programs The Children’s Hospital of Philadelphia Philadelphia, Pennsylvania

Contributors

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Michael T. Sorter, MD Professor of Psychiatry and Pediatrics University of Cincinnati College of Medicine Director, Division of Child and Adolescent Psychiatry Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Michael G. Spigarelli, MD, PhD Assistant Professor of Pediatrics and Internal Medicine University of Cincinnati College of Medicine Director, Clinical Trials Office Associate Director of Clinical Pharmacology Director of Fellowship Training, Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Cathleen M. Steinegger, MD, MSc Assistant Professor of Pediatrics University of  Toronto Division of Adolescent Medicine The Hospital for Sick Children Toronto, Ontario Aneesh K. Tosh, MD, MS Assistant Professor of Clinical Child Health University of Missouri-Columbia Divisions of Adolescent Medicine and Pediatric Endocrinology University of Missouri Hospitals and Clinics Columbia, Missouri Elaine M. Urbina, MD Associate Professor of Pediatrics University of Cincinnati College of Medicine Director of Preventive Cardiology Division of Cardiology Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Daniel A. Vogel, MD Assistant Professor of Psychiatry and Pediatrics University of Cincinnati College of Medicine Division of Child and Adolescent Psychiatry Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio Thomas S. Webb, MD, MSc Assistant Professor of Clinical Medicine and Pediatrics University of Cincinnati College of Medicine Division of Developmental Disabilities Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio



Contributors

Mark L. Wolraich, MD Professor of Pediatrics University of Oklahoma College of Medicine CMRI Shaun Walters Endowed Chair in Developmental & Behavioral Pediatrics Chief, Section of Developmental and Behavioral Pediatrics Director, Child Study Center University of Oklahoma Health Sciences Center Oklahoma City, Oklahoma Nichole Zidenberg, MD Assistant Clinical Professor of Obstetrics and Gynecology University of California Davis Director,  Teen Clinic Kaiser Permanente, Roseville Roseville, California

Michele L. Zucker, MD, MPH Assistant Professor of Pediatrics University of Cincinnati College of Medicine Division of Adolescent Medicine Cincinnati Children’s Hospital Medical Center Cincinnati, Ohio

Foreword

The specialty of adolescent medicine evolved from the incubator of general pediatrics. Emergency medicine is another example of a non-organ–based subspecialty. As one reads the eighth volume of The Requisites in Pediatrics, it is clear why adolescent medicine is so important and is a subspecialty in pediatrics. In this carefully edited volume, Dr. Gail Slap paints a clear picture of the issues that confront the adolescent patient in a time of dramatic physical, cognitive, emotional, and social growth. The authors repeatedly make the point that addressing adolescent health issues in the context of these changes is vital to providing outstanding care. Furthermore, Dr. Slap and the authors have, whenever possible, made recommendations that are ­evidence-based. The volume starts off with “Normal Growth and Development,” which outlines cognitive, social, and phy­ siologic changes during adolescence.The statement “20% of adult height and 50% of adult skeleton are accrued during the teen years” indicates the importance of the fourth chapter on nutrition and a subsequent chapter (Chapter 11) on obesity. Other chapters in the first part of the volume are especially valuable, notably chapters entitled “Approaching Youth Violence in a Clinical Setting” (with a figure labeled “A life-saving decision tree”),

“Tran­sition to Adult Health Care,” and “Consent, Confiden­ tiality, and Privacy.” Part II of the book includes common medical problems that are present to the office, such as delayed puberty, hypertension, acne, headaches, and fatigue. Parts III and IV are outstanding sections dealing with the important issues of sexual/reproductive health and mental/­behavioral problems. My thanks and congratulations to Dr. Slap and the authors of Adolescent Medicine. They have produced an outstanding and easy-to-use book that provides evidencebased information on the most important questions and medical conditions confronting adolescents. We are confident that you will find the latest volume of The Requisites in Pediatrics most useful.

Louis M. Bell, MD Patrick S. Pasquariello, Jr. Endowed Chair in General   Pediatrics Professor of Pediatrics University of Pennsylvania School of Medicine Chief, Division of General Pediatrics Attending Physician, General Pediatrics and Infectious   Diseases The Children’s Hospital of Philadelphia Philadelphia, Pennsylvania

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Preface

My decision to serve as Editor for Adolescent Medicine: The Requisites in Pediatrics grew out of opportunity. I have had the unique good fortune to lead two remarkable programs in adolescent medicine at The Children’s Hospital of Philadelphia and the Cincinnati Children’s Hospital Medical Center. As the book took shape and form, it offered a canvas on which to capture the curricular content and process of adolescent-centered care as provided at these two leading institutions.The book is the product of talented faculty whose clinical brilliance was honed under the trusting eye of their adolescent. As such, it is dedicated to the patients, families, and colleagues. Patients who keep us reaching for the highestquality adolescent care. The focus of this book is adolescent medicine.While it incorporates clinical material from diverse fields, including pediatric and adult medicine, behavioral and mental health, reproductive and sexual health, sports medicine, and nutrition sciences, it is written for primary-care physicians, residents, and fellows who care for adolescent-aged patients. Characteristics that set this book apart from other adolescent texts are its visual content, electronic availability, and curricular orientation. We hope that it becomes the open book and active computer screen for trainees on block rotations in adolescent medicine as well as for busy clinicians faced with complex adolescent health issues.

The book is divided into four sections: I. General Issues in Adolescent Health Care; II. Common Medical Problems; III. Sexual and Reproductive Health; and IV. Mental and Behavioral Problems. The nine chapters in Section I provide a concise, readable overview of cross-cutting issues such as normal growth and development, preventive care, and transition to adult care. The 30 chapters in Sections II–IV share a common organizational structure. Each chapter opens with an outline of its topic-specific sub-headings within the shared structure of Definitions, Epidemiology, Pathophysiology, Evaluation, Management, Major Points, and Bibliography. The text and illustrations are evidence-based or, when evidence is lacking, guided by expert opinion. To maintain high readability and portability, we decided against heavily-referenced text and long bibliographies. The reference lists therefore include print and web-based documents that are topical, timely, and readily accessible. This book, as all books, should be a living, changing resource that reflects the science and art of our field. While many argue that a book is outdated before it appears, starting somewhere gives us a baseline for lifelong improvement. I hope this book provides a strong foundation for those who care for adolescents and work toward the continual improvement of adolescent health.

Gail B. Slap, MD, MS

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Acknowledgments

Adolescent Medicine: Requisites in Pediatrics represents the concerted effort of 44 chapter authors. The content of the book reflects the breadth and depth of their clinical acumen and dedication to sensitive, evidence-based care. The form of the book and its progress through the preparatory stages are thanks to the steady guidance of many at Elsevier, including Judith Fletcher, Executive Publisher; Joanne Husovski, Former Editor; Alan Palmer, Project Manager; Bryan Hayward,

Project Manager; and Martha Limbach, Associate Deve­ lopmental Editor. This book would not exist without Lynn Hanrahan, Senior Administrative Assistant in the Division of Adolescent Medicine, Cincinnati Children’s Hospital Medical Center. Lynn is the organizational force and communications master behind this project. It is Lynn who monitored the detail, maintained our momentum, and kept us smiling from start to finish.

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General Issues in Adolescent Health Care



Pa r t

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1

C h Ap t e r

Introduction Cognitive Development Social Development Onset and Timing of Puberty Parameters of Pubertal Maturation Problems Encountered During Puberty

Introduction Profound changes occur in the biological, cognitive, and social dimensions during the second decade of life. Although the content of these dimensions and the timing of their changes vary considerably, their overlap and interactions are hallmarks of adolescence. This chapter focuses on puberty, or maturation of the biological dimension. It opens with a review of the cognitive and social contexts within which puberty occurs. The triggers and timing of the onset of puberty are then discussed, followed by a review of its staging and dimensions. The final section presents common problems of pubertal ­development that present during adolescence.

Cognitive development During the pre-teen and teen years, most adolescents progress from the Piaget stage of concrete thought to the stage of formal operational, or abstract, thought. They begin to understand subtleties in communication and how their current behaviors may impact future outcomes. They begin to think about thinking, both as it relates to their own thoughts and to the thoughts of others. Theoretical consequences of this reflection are the “imaginary audience” described by Elkind and the “personal fable.”  The imaginary audience refers to the belief that others are watching and invested in the adolescent’s

Normal Growth and Development Frank M. Biro, MD

thoughts and action.  The personal fable refers to a sense of invulnerability arising from the adolescent’s perception of unique, individual attributes. Communication between adolescent patients and health care providers provides many examples of these cognitive changes. For example, an adolescent may respond to provider questions with partial answers, believing that answers ­obvious to the adolescent are also obvious to the provider. When faced with stressful or emotional situations, adolescents who previously demonstrated cognitive maturity may revert to less sophisticated thought strategies. Research suggests that this reversion reflects the flux between cool, or objective, and hot, or affective, cognition. The region of the brain that integrates cognitive and affective information matures relatively late in adolescence, resulting in an intensified effect of emotional setting on decision and action.

Social development The social tasks of adolescent development include the development of psychosexual identity, increasing autonomy from parents, and a future orientation toward adult role and responsibilities. Early adolescence (ages 11–14 years) coincides with the social transition from elementary to middle school and the associated changes in peer group, academic expectations, and teacher–student interactions. Peer influence and parent–teen conflict tend to increase during these years. Self-esteem can change dramatically and is strongly associated with gender, race, family, and school. White girls are particularly susceptible to a decline in self-image during early adolescence, with recovery by late adolescence. The decline is less in black than white girls, and self-esteem in boys tends to increase throughout adolescence. By mid to late adolescence, conflicts between teens and parents typically diminish. Older adolescents shift 

 Adolescent Medicine: The Requisites in Pediatrics

their focus to college, vocational training, and/or work as they move toward increasing self-sufficiency. Self- and sexual identity tend to stabilize, and adolescents begin to envision their roles as adults within families and communities. Although many older adolescents depend on their parents for continued financial support, personal and social expectations of independence accelerate with the completion of puberty and the achievement of physical maturity.

Onset and Timing of Puberty Pubertal maturation begins with reactivation of the hypothalamic-pituitary-gonadal axis. Luteinizing hormone– releasing hormone (LHRH), also called gonadotropinreleasing hormone (GnRH), is secreted during fetal development, and the hypothalamic pulse generator remains active for 6–12 months after birth. Increased sensitivity of the hypothalamus to negative feedback from the gonadal sex steroids results in low levels of LHRH during childhood. The mechanism underlying reactivation of the LHRH pulse generator is unclear, but leptin appears to be an important mediator. Leptin is produced by fat cells, and its concentration in the serum correlates with the percentage of body fat. The administration of leptin to leptin-deficient animals has been shown to trigger puberty, and high serum levels of leptin in humans is associated with earlier pubertal maturation. The timing and triggers of puberty have been subjects of intense study for more than 30 years. European and U.S. data on the age of menarche, dating back to the late 1800s, shows a steady downward trend through the first half of the twentieth century. Information about the ages of pubertal onset and progression is less reliable than that on menarche, and analyses regarding secular trends in the ages of pubertal onset and progression have generated ­considerable controversy. In 1997, Herman-Giddens et al. published a cross­sectional study suggesting that maturation was occurring earlier in U.S. females than previously demonstrated. Using data from 17,000 visits to pediatric offices in the early 1990s, the investigators reported that 48% of black girls and 15% of white girls at age 8 years had breast or pubic hair development. Although the age of maturation was younger than expected, the mean ages of menarche for black (12.2 years) and white (12.9 years) girls differed little from the ages reported for girls in the 1970s. A 2005 study by Sun et al. addressed the key question raised by the Herman-Giddens study: Is sexual maturity occurring earlier among U.S. children? The authors compared sexual maturity data from the 1966–1970 National Health Examination Surveys (NHES),1982–1994 Hispanic Health and Nutrition Examination Surveys (HHANES), and the 1988–1994 National Health and Nutrition

Examination Surveys III (NHANES III).  Although comparison of pubertal onset is limited by the relatively high ages of enrollment at 12 years for NHES and NHANES III and 10 years for HHANES, the authors conclude that the evidence does not support a trend toward earlier maturation between the 1960 and 1990s for black boys, black girls, or white girls. The data do suggest a downward trend for white boys, Hispanic boys, and Hispanic girls. Tables 1-1 and 1-2 show the percentages of subjects who had reached Tanner stage 2 or higher at two time points in the three data sets. The timing of pubertal maturation can have both shortand long-term effects on physical appearance and

Table 1-1 Percentages of White and Black Children in the United States Aged 12–13 Years Who Are Tanner Stage 2 or Greater

White girls   Breast   Pubic hair Black girls   Breast   Pubic hair White boys   Genital   Pubic hair Black boys   Genital   Pubic hair

NHES 1

NHANES III 2

1966–1970

1988–1994

94 95

93 95

94 90

98 89

73 68

91 71

78 71

89 82

National Health and Examination Surveys (NHES). National Health and Nutrition Examination Surveys (NHANES) III. From Sun SS, Schubert CM, Liang R, et al.: Is sexual maturity occurring earlier among U.S. children? J Adolesc Health 2005;37:345–355.

1 2

Table 1-2 Percentages of Mexican-American Children in the United States Aged 10–11 Years Who Are Tanner Stage 2 or Greater

Girls Breast Pubic hair Boys Genital Pubic hair

HHANES1

HHANES

1982–1984

1988–1994

40  7

70  4

11 90

46 89

1 Hispanic Health and Nutrition Examination Surveys (HHANES) 1982–1984 and 1988–1994. From Sun SS, Schubert CM, Liang R, et al.: Is sexual maturity occurring earlier among U.S. children? J Adolesc Health 2005;37:345–355.

Normal Growth and Development

­ sychosocial function. For example, early maturation in p both males and females is associated with shorter adult stature.  Among females, earlier maturation is associated with lower self-esteem and body image; earlier-onset sexual activity; increased rates of eating disorders, depression, and substance use during adolescence; and poorer adjustment skills and relationships during adulthood. Late maturation in males is associated with adolescent and adult disruptive behavior and substance abuse, whereas in females it is associated with a higher likelihood of on-time college graduation.

Parameters of Pubertal Maturation Puberty affects virtually all body systems. The most evident changes are growth in height, weight gain, and the appearance of secondary sexual characteristics. However, striking changes also occur in body composition, organ system size and function, and biochemical parameters. As shown in Figure 1-1, the patterns of growth during puberty differ for the skeletal (i.e., general), genital, lymphoreticular, and nervous systems. General and genital growth rates accelerate during puberty, lymphoreticular growth decelerates, and nervous system growth ­plateaus.



Puberty in the individual is best described from the perspectives of its sequence, timing, and tempo. The sequence of change is commonly described by the “Tanner” stages of pubertal maturation, defined by Marshall and Tanner. Ratings of one (pre-pubertal child) to five (mature adult) are assigned separately to breast (Figure 1-2) and pubic hair development (Figure 1-3) in females and to genital (Figure 1-4) and pubic hair development in males. Since the development of the Tanner stages, estimation of testicular volume (Figure 1-5) has been shown to be a more reliable measure of male maturation than pubic hair. Figures 1-6 and 1-7 illustrate height velocity in females and males, respectively, as a function of chronological age and in relationship to other key events of puberty. Peak height velocity (PHV) occurs relatively early in female puberty, at a mean Tanner stage of 2–3, and

M-1

M-2 200

Size attained as percent of postnatal growth

175

Lymphoid M-3

150

125 M-4

100 Neural 75 General 50

M-5

Figure 1-2     Stages of breast development in girls. Stage 1: 25 Genital 0 0

2

4

6

8

10

12

14

16

18

20

Age (years)

Figure 1-1    Growth curves of selected body systems, by age. From Harris JA, Jackson CM, Paterson DG, et al.: The Measurement of Man. Minneapolis, University of Minnesota Press, 1930.

Prepubertal, with no palpable breast tissue. Stage 2: Breast bud; elevation of the papilla and enlargement of areolar diameter. Stage 3: Enlargement of the breast, without separation of areolar contour from the breast. Stage 4: Formation of secondary mound above breast, from projection of areola and papilla. Stage 5: Recession of areola to contour of breast; papilla beyond contour of areola and breast. From Roede MJ, van Wieringen JC: Growth diagrams 1980: Netherlands third nation-wide survey. Tijdschr Soc Gezondheids 1985;63(Suppl):1–34.

 Adolescent Medicine: The Requisites in Pediatrics

P-1

P-2

P-3

P-4

P-5

Stage 1

Stage 2

Stage 3

Stage 4

Stage 5

Stage 6

P-6

Figure 1-3    Stages of pubic hair development in girls. Stage 1:

­ enarche occurs relatively late, at a mean Tanner stage m of 4. Body composition in girls changes rapidly after the PHV, with an increase in percent body fat. Most of the increase in female body mass index (BMI) before age 16 years is explained by an increase in lean body mass, whereas most of the increase after age 16 years is explained by an increase in body fat. The median and 95th percentile intervals between the onset of female puberty and ­ menarche are 2.6 years and 4.5 years, respectively. Body composition in boys changes little during puberty, and most of the increase in BMI is explained by an increase in lean body mass. PHV occurs in midlate puberty, and the strength spurt occurs approximately 1 year later, near the completion of puberty. The earliest sign of puberty in boys is an increase in testicular volume, followed by the appearance of pubic hair approximately 6 months later.

Figure 1-4    Stages of pubic hair development in boys. Stage 1: Prepubertal with no pubic hair. Stage 2: Sparse, straight hair along the base of the penis. Stage 3: Hair is darker, coarser, and curlier, extending over the mid-pubis. Stage 4: Hair is adult-like in appearance, but does not extend to the thighs. Stage 5: Hair is adult in appearance, extending from thigh to thigh. Some describe PH6 as hair growth along linea alba. From Roede MJ, van Wieringen JC: Growth diagrams 1980: Netherlands third nation-wide survey.  Tijdschr Soc Gezondheids 1985;63(Suppl):1–34. TESTICULAR VOLUME IN BOYS, BY PUBERTAL STAGE 30 Testicular volume (ml)

Prepubertal with no pubic hair. Stage 2: Sparse, straight hair along the lateral vulva. Stage 3: Hair is darker, coarser, and curlier, extending over the mid-pubis. Stage 4: Hair is adult-like in appearance, but does not extend to the thighs. Stage 5: Hair is adult in appearance, extending from thigh to thigh. Some describe PH6 as hair growth along linea alba. From Roede MJ, van Wieringen JC: Growth diagrams 1980: Netherlands third nation-wide survey. Tijdschr Soc Gezondheids 1985;63(Suppl):1–34.

25

95%

20 15

50%

10

5%

5 0 2a

2b

3

4

5

Pubertal stage

Figure 1-5     Testicular volume in boys, by pubertal stage. Stage 2a: PH1 with pubertal testicular volume; stage 26: PH2; stage 3: PH3; etc. From Biro FM, Lucky AW, Huster GA, et al.: Pubertal staging in boys. J Pediatr 1995;127:100–102.

Normal Growth and Development SEQUENCE OF PUBERTAL EVENTS—GIRLS

Peak height velocity Height velocity

Onset of puberty

8

9

10

11

Completion of puberty

Menarche

12

13

14

15

16

17

Age in years

Figure 1-6    Sequence of pubertal events—girls. Data from Biro FM, Huang B, Crawford PB, Lucky AW, et al.: Pubertal correlates in black and white girls. J Pediatr. 2006;148:234–240. Figure will appear in: Biro FM: Puberty: Whither goest? J Pediatr Adolesc Gynecol 2006; 19:163–165. SEQUENCE OF PUBERTAL EVENTS—BOYS Peak height velocity

Sperm in urine

Height velocity

Increase in testicular vol

10

11

Strength spurt

Completion Pubic hair stage 2 of pubic hair 5

12

13

14

15

16

17

18

Age in years

Figure 1-7    Sequence of pubertal events—boys. Data from Biro FM, Lucky AW, Huster GA, et al.: Pubertal staging in boys. J Pediatr 1995;127:100–102. Karpati AM, Rubin CH, Sieszak SM, et al.: Stature and pubertal stage assessment in American boys: The 1988–1994 Third National Health and Nutrition Examination Survey. J Adol Health 2002; 30:205–212. Martin RJF, Dore E,Twisk J, et al.: Longitudinal changes of maximal short-term peak power in girls and boys during growth. Med Sci Sports Exerc 2004;36:498– 503. Neu CM, Rauch F, Rittweger J, et al.: Influence of puberty on muscle development at the forearm. Am J Physiol Endocrinol Metab 2002;283:E103–107.

Problems Encountered During Puberty Issues that are statistically normative for the adolescent population are commonly viewed as abnormal for or by individual adolescents.  The clinical challenge rests in differentiating pathology that requires early intervention from normal physiology that can be monitored or managed conservatively. Four examples of these issues—acne,



gynecomastia, musculoskeletal symptoms, and myopia— are discussed below. Acne may be a harbinger of normal pubertal development or may represent increased exposure or sensitivity to androgenic stimulation. It affects 85% of adolescents and resolves by young adulthood in 80% of those affected. All acne deserves clinical attention given the many therapeutic options now available, but not all acne warrants medical evaluation for underlying disorders. In males, severe acne unresponsive to topical treatment and oral antibiotics may be the only sign of hyperandrogenism. Females with acne that is accompanied by menstrual irregularity, hirsutism, excessive weight gain, acanthosis nigricans, or clitoromegaly should be evaluated for causes of ovarian or adrenal hyperandrogenism, such as polycystic ovary syndrome or congenital adrenal hyperplasia. The presentation, evaluation, and management of acne are discussed in detail in Chapter 15. Gynecomastia, or male breast development, occurs in 50% of adolescent males and resolves spontaneously within 24 months in 90% of those affected. The probable cause is increased exposure or sensitivity to estrogenic stimulation, usually resulting from the peripheral aromatization of testosterone to estrogen. Most adolescent gynecomastia is managed by reassurance and watchful waiting, but boys with palpable breast tissue that exceeds 2 cm in diameter or persists beyond 24 months should be evaluated for hypogonadism (e.g., Klinefelter syndrome), hyperthyroidism, testicular tumors, or the use of medications associated with inhibition of androgen synthesis (e.g., ketoconazole) or receptors (e.g., cimetidine). Musculoskeletal complaints are common during adolescence because of dynamic changes associated with the growth spurt, such as the organization of new bone, elongation of the extremities, and responsiveness of ligaments and tendons to sex steroids. Flexibility tends to decrease, resulting in muscular strains and sprains, apophyseal inflammation, and stress fractures. Many of the conditions are related to overuse and respond quickly to rest. Others are unrelated to exercise but stabilize without intervention (e.g., mild scoliosis). Chapter 3 discusses the musculoskeletal examination, and Chapter 18 discusses common problems of the back, hip, and knee during adolescence. Myopia, or near-sightedness, typically begins or worsens during puberty. The cause is unknown, but family history of myopia and increased work requiring close vision appear to increase the risk of its development. Myopia that is readily corrected with glasses or contact lenses and that stabilizes during young adulthood typically does not require evaluation for underlying pathology. However, refractive errors during adolescence that progress beyond -6D are at risk of degenerative myopia and do warrant evaluation for underlying conditions (e.g., Marfan, Ehlers-Danlos, Stickler syndromes).

 Adolescent Medicine: The Requisites in Pediatrics

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Major Points

b

Puberty refers to the biological and physical changes of adolescence that result in reproductive maturity. These biological changes occur within the context of cognitive and social development, resulting in abstract thought, psychosexual identity, increasing independence, and a future orientation to adult roles and responsibilities. Pubertal maturation begins with reactivation of the hypothalamic-pituitary-gonadal axis for the first time since fetal life. The age of pubertal onset declined in males and females during the twentieth century. The major parameters by which puberty is measured are the Tanner stages of sexual maturity, menarche in females, testicular volume in males, peak height velocity, and changes in body composition. The Tanner stages in females refer to the stages of breast and pubic hair development. The Tanner stages in males refer to the stages of genital and pubic hair development. In females, peak height velocity (PHV) occurs ­relatively early in the course of puberty.  The increase in body mass index before and during the PHV reflects an increase in lean body mass, whereas the increase after the PHV reflects an increase in body fat. In males, PHV occurs relatively late in puberty and reflects an increase in lean body mass. Peak strength spurt occurs 1 year after the PHV. Developmental issues related to puberty include acne, gynecomastia, musculoskeletal complaints, and myopia. For most adolescents, these ­problems resolve or stabilize with the completion of puberty. A major goal of adolescent health is to ­differentiate between normative problems that can be managed ­conservatively and problems that require more aggressive intervention.

Bibliography Anderson SE, Dallal GE, Must A: Relative weight and race influence average age at menarche: Results from two nationally representative surveys of US girls studied 25 years apart. Pediatrics 2003;111(4 Pt 1):844–850. Biro FM, Huang B, Crawford PB, Lucky AW, et al.: Pubertal correlates in black and white girls. J Pediatr 2006;148:234–240. Biro FM, Lucky AW, Huster GA, et al.: Pubertal staging in boys. J Pediatr 1995;127:100–102. Biro FM, Lucky AW, Simbartl LA, et al.: Pubertal maturation in girls and the relationship to anthropometric changes: Pathways through puberty. J Pediatr 2003;142:643–646. Biro FM, McMahon RP, Striegel-Moore R, et al.: Impact of timing of pubertal maturation on growth in black and white female

adolescents: The National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr 2001;138:636–643. Chumlea WC, Schubert CM, Roche AF, et al.: Age at menarche and racial comparisons in U.S. girls. Pediatrics 2003;111: 110–113. Dahl RE: Adolescent brain development: A period of vulner­ abilities and opportunities. Ann NY Acad Sci 2004;1021:1–22. Grumbach MM: The neuroendocrinology of human puberty revisited. Horm Res 2002;57(Suppl 2):2–14. Herman-Giddens ME, Slora EJ, Wasserman RC, et al.: Secondary sexual characteristics and menses in young girls seen in office practice: A study from the Pediatric Research in Office Settings Network. Pediatrics 1997;99:505–512. Herman-Giddens ME, Kaplowitz PB, et al.: Navigating the recent articles on girls’ puberty in Pediatrics: What do we know and where do we go from here? Pediatrics 2004;113:911–917. Kaplowitz PB, Slora EJ, Wasserman RC, et al.: Earlier onset of puberty in girls: Relation to increased body mass index and race. Pediatrics 2001;108:347–353. Karpati AM, Rubin CH, Sieszak SM, et al.: Stature and pubertal stage assessment in American boys: The 1988–1994 Third National Health and Nutrition Examination Survey. J Adolesc Health 2002;30:205–212. Marshall WA, Tanner JM: Variations in pattern of pubertal changes in girls. Arch Dis Child 1969;44:291–303. Marshall WA, Tanner JM: Variations in the pattern of pubertal changes in boys. Arch Dis Child 1970;45:13–23. Martin RJ, Dore E, Twisk J, et al.: Longitudinal changes of maximal short-term peak power in girls and boys during growth. Med Sci Sports Exerc 2004;36:498–503. Maynard LM, Wisemandle W, Roche AF, et al.: Childhood body composition in relation to body mass index. Pediatrics 2001;107:344–350. Neu CM, Rauch F, Rittweger J, et al.: Influence of puberty on muscle development at the forearm. Am J Physiol Endocrinol Metab 2002;283:E103–107. Ogden CL, Flegal KM, Carroll MD, et al.: Prevalence and trends in overweight among US children and adolescents, 1999–2000. JAMA 2002;288:1728–1732. Roede MJ, van Wieringen JC: Growth diagrams 1980: Netherlands third nation-wide survey. Tijdschr Soc Gezondheids 1985;63(suppl):1–34. Sun SS, Schubert CM, Liang R, et al.: Is sexual maturity occurring earlier among U.S. children? J Adolesc Health 2005;37:345–355. Wang Y: Is obesity associated with early sexual maturation? A comparison of the association in American boys versus girls. Pediatrics 2002;110:903–910. Wattigney WA, Srinivasan SR, Chen W, et al.: Secular trend of earlier onset of menarche with increasing obesity in black and white girls: The Bogalusa Heart Study. Ethn Dis 1999;9: 181–189.



C h A p t er

2

Introduction Expert Recommendations and the Evidence Base for Adolescent Preventive Care Elements of Adolescent Preventive Care Physical Assessment Behavioral Screening and Anticipatory Guidance Laboratory Screening Immunizations Counseling for Behavioral Change Office Systems to Enhance Adolescent Preventive Care

Introduction Adolescence is a time of dramatic physical, cognitive, and emotional growth. Health care providers can play an important role in helping adolescents and their families effectively navigate these transitions and enter adulthood with a strong foundation for lifelong healthy habits. Clinical preventive services complement community-based positive development programs and public health interventions in optimizing the health of adolescents. Most adolescents and their families progress though adolescence with few significant problems, and the rates of many risk behaviors have decreased over the past decade. On the other hand, rates of obesity and physical inactivity are increasing rapidly. Adolescents with medical and behavioral risks, as well as those with special health care needs, may be less likely than those who are low-risk to seek preventive care, making proactive screening and intervention important during all clinical contacts.

Preventive Health Care Maria T. Britto, MD, MPH

Expert Recommendations and the Evidence Base for Adolescent Preventive Care Most expert groups, such as the American Academy of Pediatrics (AAP), the American Medical Association (AMA), the American Academy of Family Practitioners (AAFP), and the Maternal and Child Health Bureau (MCHB), make similar recommendations. The United States Preventive Services Task Force (USPSTF) has the most stringent criteria for recommending a preventive intervention. Generally, the USPSTF makes a recommendation only if there is evidence of the effectiveness of the intervention, such as for immunizations and chlamydia screening in sexually active female adolescents. If there is good evidence of lack of effectiveness or of harm, the USPSTF usually recommends against the specific intervention. For example, it explicitly recommends against routine scoliosis screening of adolescents. In many other areas, especially in screening and counseling for lifestyle or behavioral issues, evidence is lacking and the USPTF makes no recommendation. Most other organizations will make a recommendation in the absence of evidence if it addresses a substantial public health issue (e.g., obesity) or there is evidence of effectiveness in other populations. For example, screening for tobacco use and cessation counseling have good evidence of effectiveness in adults, but little similar data are available in adolescents. The USPSTF makes no recommendation, but Bright Futures, endorsed by multiple groups, recommends tobacco screening and cessation counseling for adolescents.



10

Adolescent Medicine: The Requisites in Pediatrics

Guidelines change frequently as new evidence becomes available and can be obtained online at http:// www.ahrq.gov/clinic/prevenix.htm, http://www.aafp. org/online/en/home/clinical/exam.html, and http:// www.brightfutures.org. The key elements of adolescent preventive care are summarized in Box 2-1.

Box 2-2  Screening and Anticipatory Health Guidance For Adolescents l

Elements of Adolescent Preventive Care Physical Assessment Many adolescents, parents, and clinicians expect preventive care to include a routine, annual physical examination, despite its unproven clinical value. Key components that should be performed during early, mid, and late adolescence include measurement of blood pressure, height and weight; calculation of body mass index (BMI); determination of height, weight, and BMI percentiles from ageand sex-adjusted growth charts; and determination of pubertal maturation by Tanner staging of breast and pubic hair development in females and genital and pubic hair development in males (Chapter 1). Bright Futures also recommends objective vision screening with a Snellen test during early, mid, and late adolescence, based on expert consensus. The decision about whether a parent leaves or remains during the physical examination generally should be made by the adolescent.

Behavioral Screening and Anticipatory Guidance Evidence supporting the effectiveness of behavioral screening and anticipatory guidance is weak during adolescence as well as earlier childhood. However, screening is recommended based on its potential benefit and low risk of harm. The key behavioral screening and anticipatory guidance topics for adolescents and their parents are outlined in Box 2-2.

Box 2-1  Elements of Preventive Care for

Adolescents

l l l

l l l

Address adolescent and family concerns Physical assessment Screening l Development l Social and academic competence l Risky behavior l Violence Immunizations Preventive counseling/anticipatory guidance Interventions for identified problems

l l l l l

Normal development l Physical l Emotional l Social l Academic l Sexual Nutrition Physical activity Violence and injury prevention Responsible sexual behavior Avoidance of substances

For Parents of Adolescents l

l

l

Normal adolescent development l Physical l Cognitive l Academic l Social l Emotional l Sexual Parenting behaviors and styles that promote healthy development, including parental monitoring Role modeling healthy lifestyle and behaviors

Behavioral screening and guidance generally should be conducted with the adolescent alone, unless the adolescent requests the parent’s presence. It is best to start the interview with less sensitive areas of inquiry, such as school and leisure activities, and progress to more sensitive areas such as depression and sexuality. A useful mnemonic for recalling the elements and sequencing of the psychosocial interview is HEADDS, which stands for Home, Education, Activities (social, work, sports), Drugs, Depression, Sexuality, and Safety (risk for intentional and unintentional injury). The Bright Futures materials have extensive lists of trigger questions and anticipatory guidance suggestions for each of the key areas, as well as screening checklists for parents, adolescents, and providers. Adolescent and family strengths should be sought and reinforced.

Laboratory Screening No routine laboratory tests are universally recommended during adolescence. Consequently, laboratory screening should be tailored to the adolescent’s individual risk profile. Annual chlamydia screening is recommended in all sexually active females because of its high prevalence and risk for progression to pelvic inflammatory disease. The individual benefit of screening is less clear in the adolescent male and, because of the weaker ­evidence



Preventive Health Care

base, there is controversy about the routine screening of males for chlamydia. Gonorrhea screening is recommended by the USPSTF for high-risk females, including all sexually active females younger than age 25. Cervical cancer screening is recommended 3 years after the onset of vaginal sexual activity or at the age of 21 years. Although there is likely little value in screening young women who have never had vaginal intercourse, screening at age 21 years is recommended based on the high prevalence of sexual activity by that age and the concern that clinicians may not always obtain accurate sexual histories. Screening is risk-based for human immunodeficiency virus (HIV) (http://www.cdc.gov/mmwr/preview/ mmwrhtml/rr5019a1.htm), ­ tuberculosis (http://www. cdc.gov/mmwr/preview/mmwrhtml/rr5412a1.htm), and hypercholesterolemia (http://www.guidelines.gov/ summary/summary.aspx?doc_id=5453&nbr=003730 &string=lipid).

Immunizations There is strong evidence to support the effectiveness of immunizations during adolescence. The current schedule for adolescents is outlined in Figure 2-1, and updates can be viewed at http://www.cdc.gov/vaccines. The schedules have changed rapidly for adolescents in recent years with the development of new vaccines, such as those protecting against meningococcus and human papillomavirus (HPV). The Centers for Disease Control and Prevention (CDC) and other groups recommend that adolescent immunization occur at the 11- to 12-year-old

Age Vaccine

7–10 years

Tetanus, biphtheria, pertussis Human papillomavirus Meningococcal Pneumococcal Influenza

MPSV4

visit because routine visits decrease with advancing adolescent age and are more likely to take place in sites without vaccine tracking.

Counseling for Behavioral Change There is a large theoretical and empirical literature to guide effective behavior change counseling. The transtheoretical model, or stages of change theory, developed by Prochaska and DiClemente posits that interventions to motivate behavioral change must be tailored to the individual’s readiness to change. Change progresses through five stages: pre-contemplation (not yet considering a change); contemplation (considering a change but ambivalent); preparation (actively making plans for the change); action (making the change); and maintenance (sustaining the change). The patient in the pre-­contemplation stage should be given a clear message regarding the value of the behavior change, whereas someone in the preparation stage should be given specific assistance in setting goals and arranging the behavior change. Data pertaining to adolescents are sparse, but studies in adults demonstrate that brief advice from a physician, tailored to the patient’s stage of change, doubles the rate of smoking cessation. One popular method, developed by the National Cancer Institute, is the 5 “A”s approach (Box 2-3). Motivational interviewing is an office-based counseling technique that may be particularly useful for adolescents in the pre-contemplation and contemplation stages. Miller and Rollnick have shown that the provider

11–12 years

HPV (3 doses)

HPV series

MCV4

MCV4 MCV4

16–18 years

PPV

Range of recommended ages

Catch-up immunization

Influenza (yearly)

Hepatitis B

HepB series

Varicella

15 years Tdap

HepA series

Measles, mumps, rubella

13–14 years

Tdap

Hepatitis A

Inactivated poliovirus

11

IPV series MMR series Varicella series

Figure 2-1  Recommended adolescent immunization schedule for persons aged 7–18 years: United States, 2007. From: http://www.cdc.gov/vaccines.

Certain high-risk groups

12

Adolescent Medicine: The Requisites in Pediatrics

Box 2-3  The 5 “A”s for Brief Office-Based Interventions Ask

Determine the presence of the behavior.

Advise

Deliver a clear, personalized message about the need to change the behavior.

Assess willingness to change

Determine whether the adolescent is prepared to change his or her behavior.

Assist the behavior change

Determine short-term, concrete actions to make the behavior change; set behavioral goals. Provide adjunct therapy as appropriate (e.g., nicotine replacement for tobacco cessation).

Arrange follow-up

Schedule a follow-up visit or phone call soon after the date set for the behavior change, ideally within 1 week.

From: Manley, M, Epps, RP, Husten, C, et al.: Clinical interventions in tobacco control. A National Cancer Institute training program for physicians. JAMA 1991; 266:3172– 3173.

who tries to move beyond the patient’s current stage of change is likely to encounter resistance. In motivational interviewing, the provider accepts the current state, expresses empathy for the patient’s views and situation, helps the patient understand the discrepancy between current behavior and future goals, and supports the patient’s self-efficacy to change. Most importantly, the provider rolls with, rather than opposes, resistance. Commonly used techniques include open-ended questions, reflective listening, affirmative responses, summaries of the patient’s views, and elicitation of “change talk,” or patient articulation of potential actions to change behavior. Although it takes time to learn and implement motivational interviewing, it may be more effective in changing behavior than brief office advice.

Office Systems to Enhance Adolescent Preventive Care Adolescents and young adults are less likely than any other age groups to receive recommended preventive care. Within the adolescent/young adult group, the rates of ­preventive care are particularly low among males and ethnic minorities. Thus, all health care ­interactions should be considered opportunities to provide preventive services. Analyses of the National Ambulatory Medical Care Survey and the National Hospital and Ambulatory Medical Care Survey demonstrate that behavioral and lifestyle counseling is more likely to occur at acute-care visits than ­preventive-care visits. Strong empirical evidence supports the value of systems-based approaches to clinical preventive services in all age groups, including adolescents. The key elements of effective office-based preventive service systems for adolescents are outlined in Box 2-4. The Agency for Health­care Research and Quality has developed a program to help practices implement preventive services

(www.ahrq.gov/clinic/prevenix.htm). First, the practice or organization must agree on the content of the services to be delivered. National guidelines can be adapted to local conditions. Tools such as adolescent and parent screening questionnaires, standardized preventive visit encounter forms, and preventive service flow-sheets improve efficiency and help ensure that all required areas are addressed. Electronic health records are particularly well-suited to the delivery of preventive care because of their internal prompts, reminders, protocols, and ­capacity for customized screening and advice. The efficient delivery of preventive care also depends on clarity regarding the roles and responsibilities of clinical and administrative staff. Some practices have a ­designated preventive care coordinator. Tracking systems to record key services received (e.g., immunizations and chlamydia screening), recall strategies to contact adolescents who have missed recommended services, and system updates to meet changing public health goals are ­essential components of quality care.

Box 2-4  Elements of an Office-Based Pre-

ventive Care System

1. Preventive care protocols based on evidence and/or consensus 2. Use of effective tools (flow-sheets, prompts, standing orders) 3. Clear staff roles for service delivery and monitoring of results 4. Audit and feedback to providers 5. Ongoing quality improvement efforts in order to meet established local or national goals



Preventive Health Care

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Adolescents infrequently make preventive visits, so all heath care encounters should be used as ­opportunities to provide preventive care. Office-based preventive care complements ­public health- and community-based approaches to ­improving health of adolescents. Preventive care for adolescents encompasses physical assessment; developmental, behavioral, and laboratory screening; immunizations; anticipatory guidance; and intervention for identified problems. Office-based behavioral interventions should be based on the adolescent’s readiness to change and should include effective techniques such as brief advice and motivational interviewing.

Bibliography Agency for Healthcare Research and Quality: A step-by-step guide to delivering clinical preventive services: A systems approach. Put prevention into practice. AHRQ Publication No. APPIP 01–0001, 2001. Anand V, Biondich PG, Liu G, et al.: Child health improvement through computer automation: the CHICA system. Medinfo 2004;11(Pt 1):187–191. Erickson SJ, Gerstle M, Feldstein SW: Brief interventions and motivational interviewing with children, adolescents, and their parents in pediatric health care settings: A review. Arch Pediatr Adolesc Med 2005;159:1173–1180. Fairbrother G, Scheinmann R, Osthimer B, et al.: Factors that influence adolescent reports of counseling by physicians on risky behavior. J Adolesc Health 2005;37:467–476.

13

Farmer TW, Farmer EM: Developmental science, systems of care, and prevention of emotional and behavioral problems in youth. Am J Orthopsychiatry 2001;71:171–181. Irwin CE, Jr: Clinical preventive services for adolescents: Still a long way to go. J Adolesc Health 2005;37:85–86. Ma J, Wang Y, Stafford RS: U.S. adolescents receive suboptimal preventive counseling during ambulatory care. J Adolesc Health 2005;36:441. Miller W, Rolnick S: Motivational Interviewing: Preparing People to Change Addictive Behavior. New York, Guilford, 1991. Newacheck PW, Hung YY, Park MJ, et al.: Disparities in adolescent health and health care: Does socioeconomic status matter? Health Serv Res 2003;38:1235–1252. Ozer EM, Adams SH, Lustig JL, et al.: Increasing the screening and counseling of adolescents for risky health behaviors: A primary care intervention. Pediatrics 2005;115:960–968. Prochaska JO, DiClemente CC: Stages of change in the modification of problem behaviors. Prog Behav Modif 1992;28:183–218. Rand CM, Auinger P, Klein JD, et al.: Preventive counseling at adolescent ambulatory visits. J Adolesc Health 2005;37: 87–93. Rubak S, Sandbaek A, Lauritzen T, et al.: Motivational interviewing: A systematic review and meta-analysis. Br J Gen Pract 2005;55: 305–312. Sanci LA, Coffey CM, Veit FC, et al.: Evaluation of the effecti­ veness of an educational intervention for general practitioners in adolescent health care: Randomised controlled trial. BMJ 2000;320:224–230. U.S. Preventive ServicesTask Force. Guide to Clinical Preventive Services, 2nd ed. Baltimore, Williams & Wilkins, 1996.

ChA p t e r

3

Introduction Definitions Health Benefits Cardiovascular Mental Health Musculoskeletal

Epidemiology Physical Activity Sports-Related Injury

Management Recommendations for Regular Physical Activity Injury Prevention Return to Play

Introduction Exercise and physical activity during childhood and adolescence contribute to lifelong health and wellbeing. Compared with sedentary individuals, those who engage in regular physical activity are at reduced risk for obesity, diabetes mellitus, hypertension, coronary heart disease, stroke, osteoporosis, anxiety, and depression. This chapter reviews the effects of physical activity on cardiovascular, musculoskeletal, and mental health; the rates of exercise and physical activity during adolescence; recommendations from the Centers for Disease Control and Prevention (CDC) regarding amount and types of exercise during adolescence; and the prevention of injuries associated with physical activity.

Definitions Body mass index (BMI): A measure of adiposity, expressed as weight/height2 (kg/m2). 14

Exercise and Sports Reginald S. Ewing III, MD Albert C. Hergenroeder, MD

Exercise: Physical activity that is planned, structured, repetitive, and for the purpose of improving or maintaining physical fitness. Fitness: Composite measure of cardiorespiratory endurance, muscle endurance and strength, body composition, and flexibility. Physical activity: Bodily movement associated with skeletal muscle contraction and energy expenditure. Sufficient moderate physical activity: Activity such as walking or cycling that does not require sweating or breathing hard, lasts > 30 minutes, and occurs > 5 days per week. Sufficient vigorous physical activity: Activity such as running or basketball that is associated with sweating and breathing hard, lasts > 20 minutes, and occurs > 3 days per week.

Health Benefits Cardiovascular BMI is used to define overweight and obesity during adulthood and to identify children and adolescents who are overweight or at risk of becoming overweight (see Chapter 11). The CDC defines individuals < aged 18 years with BMI values > 95th percentile for age and sex as overweight. The 1999 National Health and Nutrition Examination Survey (NHANES) revealed that 13% of children aged 6–11 years and 14% of adolescents aged 12–19 years are overweight. This represents a 2–3% increase in overweight since NHANES III (1988–1994). In 2004, an expert panel reviewed the effects of physical activity on health outcomes in children and adolescents. Programs of moderately intense exercise lasting 30–60 minutes and repeated 3–7 days weekly were found to decrease adiposity in overweight youth without changing adiposity in normal-weight youth. Among youth



Exercise and Sports

with mild essential hypertension, 30 minutes of exercise at 80% maximal heart rate performed three times weekly was found to reduce blood pressure. Two studies in children suggest that aerobic exercise improves serum lev­ els of low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) and lowers blood pressure. In adults, sustained physical activity (i.e., 40 minutes daily, 5 days weekly, for 4 months) is required to induce and maintain improvements in serum levels of HDL-C and triglycerides.

15

of weight-bearing exercise is positively correlated with BMD. Furthermore, compared with non-weight-bearing exercises such as swimming or cycling, weight­bearing exercises such as running are associated with site-­specific increases in BMD. In adolescent females, resistance training has been shown to increase BMD of the femoral neck.

Epidemiology Physical Activity

Mental Health Many studies have demonstrated associations of exercise with improved mood and self-concept, but the mechanisms underlying the association remain controversial. Participation in sports does appear to foster the development of healthy competitiveness, sportsmanship, selfconfidence, resilience, and respect for authority. It also has been shown to decrease physical and emotional distress in healthy adolescents during high-stress times and in children and adolescents with mood disorders, attention-deficit hyperactivity disorder, learning disorders, and impaired social skills. One study of high school females demonstrated lower rates of sexual risk behaviors, pregnancy, and sexually transmitted infections among sports participants versus nonparticipants. Although it is possible that the association of exercise with improved mood and self-image is mediated by intermediate improvements in appearance, physical performance, and/or social feedback, the positive effects of physical activity on ­adolescent mental health are strong and consistent.

Musculoskeletal Aerobic training increases the numbers of slow-twitch fibers and capillaries in muscle. Resistance training increases the size and recruitment of muscle fibers, which leads to the ability to exert more force (i.e., strength). Prolonged, high-intensity exercise increases both strength and the cross-sectional area of ligaments and tendons. During childhood, high-repetition, moderate-load resistance training has been shown to increase both strength and endurance and may reduce the risk of injury during participation in organized sports. Approximately 90% of adult bone mass is attained during the first two decades of life. Optimizing bone mineral density (BMD) and strength during adolescence is believed to play a significant role in preventing osteoporosis and fractures later in life. Determinants of BMD include genetics, race, ethnicity, hormonal status, calcium intake, physical activity, and weight. Regard­less of age or gender, the total number of hours

Physical activity decreases during adolescence. A 2003 national survey of students in grades 9–12 revealed that student participation in sufficient vigorous activity (i.e., sweating and breathing hard > 20 minutes per day > 3 days per week) decreased 6% per year among females and 3% per year among males. Across all four grades, 33% reported insufficient vigorous or moderate (i.e., activity without sweating or breathing hard > 30 minutes per day > 5 days per week) activity and 12% reported no physical activity in the preceding week. Daily attendance in school physical education (PE) classes declined 42% between the 9th and 12th grades, and only 19% of all high school students reported > 20 minutes of physical activity in daily PE classes. Analyses by race/ethnicity and gender revealed that black students were less active than white students and females were less active than males. A 2000 CDC survey revealed that PE class was required by 50% of schools for 5th grade students but by only 5% of schools for 12th grade students (Figure 3-1).

Sports-Related Injury Although many adolescents are not involved in sufficient physical activity, some adolescents are involved in excessive or unsafe physical activity. Athletes who participate in intense training, multiple sports per season, or yearround competition are at increased risk of acute injury in contact sports and overuse injury in noncontact sports. As athletes involved in contact sports progress through puberty, the increase in muscle mass, strength, and generated force are believed to contribute to the increasing rate of acute injury. Contusions, strains, and sprains are the most common sports-related injuries. Ankle sprains rank first for males and females, accounting for 10–30% of all musculoskeletal sports injuries. There are an estimated 2.6 million visits to emergency departments for sports-related injuries in individuals aged 5–24 years, with a male-to-female ratio of 2:1 (48 vs. 19 visits per 1000 persons). Football causes more injuries than any other high school sport, with 41– 61% of players sustaining at least one injury annually. Gymnastics ranks second, wrestling third, and boys’ basketball fourth. Girls’ basketball and soccer have higher

16

Adolescent Medicine: The Requisites in Pediatrics

100

Percentage

80

60

50.6 50.5 51.3 51.5 50.4 39.7

Figure 3-1  Percentage of schools that require physical education by grade. Available from: http:// www.cdc.gov/HealthyYouth/shpps/factsheets/ index.htm. Accessed May 17, 2007.

32.2

40

26.2 25.1 20

13.3

9.5

5.8

5.4

10

11

12

0 K

1

2

3

4

5

6

7

8

9

Grade

rates of knee injury and surgery than any other girls’ or boys’ sport, and females in general are at higher risk than males for knee injury and tears of the anterior cruciate ligament (ACL). The usual mechanism of ACL injury is a noncontact, sudden deceleration and twisting motion (i.e., cut and plant motion). Differences in female and male training, neuromuscular response, laxity, dynamic stability, hormonal influences, and lower extremity ­alignment may all play a role. Power, strength, balance, and core stability training show promise in decreasing the incidence of ACL injury in female athletes. Pre-pubertal athletes are at a higher risk for heat injury than pubertal athletes due to their higher threshold for sweating and lower sweat rate. Overuse injuries, caused by repeated microtrauma, are common among both older children and adolescents (see Chapter 18). Examples include the traction apophysitis of Osgood-Schlatter disease (insertion of the patellar tendon on the tibial tubercle), Sever’s disease (insertion of the Achilles tendon on the calcaneus), and Little League elbow (flexor/pronator origin on the medial epicondyle). Training errors such as a sudden increase in the frequency, volume, or intensity of training have been implicated as the most common predisposing factors for overuse injury. In the United States, more than 300,000 sports-related concussions are reported each year. Concussions account for 90% of head injuries in sports, and most are sustained in football.

lawn mower) for > 30 minutes on > 5 days per week. Most intervention studies demonstrating positive health outcomes with exercise have used supervised programs of moderate to vigorous physical activity lasting 30–45 minutes and repeated 3–5 days per week. Since usual, unsupervised physical activity is likely to be less intense than this, many experts encourage school-aged youth to participate in > 60 minutes of daily, moderate-to-­vigorous physical activity that is enjoyable, developmentally appropriate, and a balance of endurance, flexibility and strength training. At least twice each week adults will benefit by performing activities using the major muscles of the body that maintain or increase muscular strength and endurance. The evidence for this is based on multiple RCTs. Six national health objectives pertaining to adolescent physical activity are included in Healthy People 2010 (Box 3-1). These objectives call for behavioral change at the individual, family, and school levels. Box 3-1  Healthy People 2010 Objectives Increase the proportion of: l

l

l

l

Management Recommendations for Regular Physical Activity The CDC recommends that adolescents participate in vigorous physical activity (e.g., basketball, swimming) for > 20 minutes on > 3 days per week, or moderate ­physical activity (e.g., fast walking, slow bike riding, pushing a

l

l

Adolescents who engage in moderate physical activity > 30 minutes daily > 5 days per week Adolescents who engage in vigorous physical activity > 20 minutes daily > 3 days per week Adolescents who participate in daily school physical education Adolescents who spend > 50% of physical education class time being physically active Adolescents who watch < 2 hours television daily on school days Schools that require daily physical education for all students

U.S. Department of Health and Human Services. Healthy People 2010. Washington D.C., January, 2000. Available from: http://www.healthypeople.gov/ document/HTML/Volume2/22Physical.htm#_Toc490380803. Accessed May 17, 2007.



Exercise and Sports

Injury Prevention Strategies for reducing the likelihood and severity of adolescent sports-related injury are summarized in Box 3-2. Examples of successful interventions include a 50% reduction in gymnastic injuries with discontinuation of competitive trampoline and an 80% reduction in softball sliding injuries with introduction of break-away bases. The objectives of the pre-participation evaluation (PPE), as shown in Box 3-3, are not intended to replace the annual health examination. The PPE was standardized in 1992 and updated in 2004 through the combined efforts of the American Academy of Family Physicians, the American Academy of Pediatrics, the American Medical Society for Sports Medicine, and the American Orthopedic Society for Sports Medicine. The PPE should take place 4–6 weeks before the start of the sports season so that there is time to evaluate and treat musculoskeletal injuries or medical conditions. Discussion with coaches, players, and parents should include review of warm-up, cool-down, hydration, overuse, strengthening, stretching, performance-enhancing drugs, and psychological stress associated with competition. These discussions can be held during the off-season, when coaches and families have more time. Box 3-2  Strategies for Potentially

Decreasing the Likelihood and Severity of Sports-Related Injury

l l l l l l

Pre-season physical examination Medical personnel at sporting events Adequate hydration during training and events Proper coaching and officiating Protective equipment Safe playing conditions

Return to Play “When can I play again?” is one of the first and most pressing questions an athlete asks following an injury. Even when return-to-play guidelines exist for an injury or condition, athletes tend to press for earlier return. The risks of premature return include re-injury or new injury that can have long-lasting consequences. A musculoskeletal injury typically progresses through the four phases of rehabi­litation outlined in Table 3-1. Phase 1 focuses on ­limiting ­further injury and controlling acute symptoms. Phases 2, 3, and 4 introduce progressive movement of the injured structure until symptom-free function is restored. Athletes who insist on returning to play before completing Phase 4 increase their risk of additional injury. Patience on their part, as well as on the part of coaches and parents,is an essential component of the ­rehabilitation process. Return-to-play recommendations following concussion are particularly controversial. The American Orthopedic Society for Sports Medicine (AOSSM) has trended away from the use of a numeric grading system and towardmore individualized management. The National Collegiate Athletic Association (NCAA) does not endorse any of the current grading systems or guidelines because of their lack of scientific validity and the ongoing controversy among experts. The final decision is therefore based on clinical judgment and negotiation with the athlete.

Table 3-1 Rehabilitation Phases Following Musculoskeletal Injury Phase

Goals

Management

1

Control pain, swelling Improve strength, flexibility Improve endurance, proprioception Return to exercise symptom-free

Rest, ice, compression, elevation Range-of-motion exercises

2 3 4

Box 3-3  Goals of the Pre-Participation

Sports Evaluation

l

l

l l

l l

To identify medical problems with risks of lifethreatening complications during participation To identify conditions that require a treatment plan before or during participation To identify and rehabilitate musculoskeletal injuries To identify and treat conditions that interfere with performance To remove unnecessary restrictions on participation To advise athletes regarding appropriate sports in which to participate

17

Resistance, endurance training Progressive training without return to play

18

Adolescent Medicine: The Requisites in Pediatrics



l



l



l

l





l

l

Major Points

b

Regular physical activity reduces the risk for obesity, diabetes mellitus, hypertension, coronary heart ­disease, stroke, osteoporosis, anxiety, and depression. During childhood, high-repetition, moderate-load resistance training has been shown to increase both strength and endurance and may reduce the risk of injury during participation in organized sports. The CDC recommends that adolescents ­participate in vigorous physical activity (e.g., basketball, ­swimming) for > 20 minutes on > 3 days per week, or moderate physical activity (e.g., fast walking, slow bike riding, pushing a lawn mower) for > 30 minutes on > 5 days per week. The PPE should take place 4–6 weeks before the start of the sports season so that there is time to ­evaluate and treat musculoskeletal injuries or medical ­conditions. Discussion with coaches, players, and parents should include review of warm-up, cool-down, hydration, overuse, strengthening, stretching, performance-enhancing drugs, and psychological stress associated with competition. Return-to-play following a sports-related injury should be delayed until the athlete has progressed through four phases of rehabilitation and is able to play symptom-free.

Bibliography Adirim TA, Cheng TL: Overview of injuries in the young athlete. Sports Med 2003;33:75–81. American Academy of Pediatrics: Intensive training and sports specialization in young athletes. American Academy of Pediatrics. Committee on Sports Medicine and Fitness. Pediatrics 2000;106(1 Pt 1):154–157. Armsey TD, Hosey RG: Medical aspects of sports: Epidemiology of injuries, preparticipation physical examination, and drugs in sports. Clin Sports Med 2004;23:255–279,vii.

Centers for Disease Control and Prevention: Healthy People 2010: Physical Activity and Fitness, 2000 (Vol. 2005). Epstein LH, Paluch RA, Kalakanis LE, et al.: How much activity do youth get? A quantitative review of heart-rate measured activity. Pediatrics 2001;108:E44. Hagen TJ: Sports medicine and the adolescent female. J Pediatr Adolesc Gynecol 2005;18:9–15. Haskell, WL, Lee IM, Pate RR, et al.: Physical activity and public health: Updated recommendations (or) adults from the American College of sports Medicine and the American Heart Association Med Sci Sports Exerc 2007;39:1423–1434. Hergenroeder AC: Prevention of sports injuries. Pediatrics 1998;101:1057–1063. Hergenroeder AC: The preparticipation sports examination in children and adolescents. UpToDate. January, 2006. Kimm SY, Glynn NW, Kriska AM, et al.: Decline in physical activity in black girls and white girls during adolescence. N Engl J Med 2002;347:709–715. Lovell M, Collins M, Bradley J: Return to play following sportsrelated concussion. Clin Sports Med 2004;23:421–441, ix. McFarland EG: Return to play. Clin Sports Med 2004;23: xv–xxiii. Patel DR, Greydanus DE, Luckstead EF, Sr: The college athlete. Pediatr Clin North Am 2005;52:25–60, vii–viii. Peterson D: Overview of the risks and benefits of exercise. UpToDate. January, 2006. Centers for Disease Control and Prevention: Physical Activity and Health: A Report of the Surgeon General. Atlanta, U.S. Department of Health and Human Services, 1996 (Vol. 2005). Strong WB, Malina RM, Blimkie CJ, et al.: Evidence-based physical activity for school-age youth. J Pediatr 2005;146:732–737. Tofler IR, Butterbaugh GJ: Developmental overview of child and youth sports for the twenty-first century. Clin Sports Med 2005;24:783–804, vii–viii.



C h A p t e r

4

Introduction Nutritional Assessment History Physical Examination Laboratory Evaluation

Nutritional Requirements Definitions Energy Vitamins and Minerals

Nutritional Supplementation Nutritional Counseling Nutrition for Athletes Nutrition During Pregnancy Vegetarianism

Introduction Nutritional evaluation and counseling are crucial elements of adolescent care. At no other time in life, except infancy, does the body experience as much growth and development. Proper nutrition and healthy eating patterns support these changes, provide energy for daily activities, and can help prevent cardiovascular disease and some types of cancer later in life. Yet appropriate nutrition is less likely during adolescence than during any other time of life. Despite the increasing rates of adolescent obesity since the 1970s, mean intakes of calcium, iron, vitamin A, and vitamin C during adolescence all remain below the Recommended Daily Allowance (RDA). The physiological and behavioral characteristics that place adolescents at risk for nutritional compromise include the following: Growth and Development: 20% of adult height and 50% of the adult skeleton are accrued during the teen years, requiring tremendous amounts of energy and nutrients, particularly iron and calcium. The onset of

Nutrition Cathleen M. Steinegger, MD, Msc

­ enstruation puts an additional strain on iron stores in m the adolescent female. Meal Pattern and Composition: Adolescent meals, especially breakfast, are often skipped or eaten on the run. The planned family dinner may be replaced by fast foods or vending machine snacks that are high in calories, fat, sodium, and sugar and low in essential nutrients. Table 4-1 shows the nutritional information for some of the fast food items commonly selected by adolescents. Dietary Experimentation: Adolescence is a time of experimentation in all aspects of life, including alternative diets such as vegetarianism. Although many diets do provide adequate nutrition when implemented correctly, adolescents may not have the knowledge or resources to develop healthy meal plans. Body Image: Rapid changes in body size and composition, peer pressure, athletics, and media influences are just some of the reasons why teens often feel dissatisfied with their bodies. This may lead to fad dieting, fasting, purging, and eating disorders. Special Circumstances: Pregnancy, substance use, chronic disease, and competitive athletics place particular strain on nutritional status during adolescence given the physiological demands of pubertal maturation.

Nutritional Assessment A nutritional assessment should be part of every health maintenance visit and is easily incorporated into routine care. For the well adolescent, screening questions during the history, routine anthropometric measurements, and a general physical examination usually suffice. Laboratory studies to assess nutritional status are not part of the routine screen and should be prompted by findings on the history or physical examination. 19

20

Adolescent Medicine: The Requisites in Pediatrics

Table 4-1  Fast Food Nutritional Comparison

McDonald’s Big Mac Hamburger Regular Hamburger Pizza Hut Meat Lover’s Pizza, 1 slice Veggie Lover’s Pizza, 1 slice Taco Bell Beef Burrito Supreme Tostada Burger King French Fries, King Size French Fries, Small Size Subway Meatball Sandwich, 6-inch Turkey Sandwich, 6-inch Wendy’s Chicken BLT Salad with dressing and croutons Chicken BLT Salad without dressing and croutons Smoothie King   Chocolate Smoothie,“The Hulk,” 20 oz.   Berry Punch Smoothie, 20 oz.

Calories (kcals)

Total Fat (g)

Cholesterol (mg)

Sodium (mg)

554 265

30  9

  80   30

1010   530

300 220

13  6

  35   15

  760   490

440 250

18 10

  40   15

1330   710

603 230

29 11

   0    0

1075   410

560 280

24  5

  45   20

1610 1020

680

47

130

1315

330

18

105

  840

846 350

29  0

102    0

  626   110

History Questions such as the following help guide the nutritional history: Tell me everything that you ate and drank yesterday from the time you woke up until the time you went to sleep. Are there any types of foods that you do not eat? How often do you eat fast food? What do you usually drink? How often do you eat fruits and vegetables? Do you take vitamins, minerals, or other supplements? How often do you skip meals? Have you made any changes in your diet? Do you want to weigh more, less, or the same as you weigh now? What do you do to achieve that goal? What questions or concerns do you have about your nutrition? The high incidence and prevalence of eating disorders during adolescence have prompted the development of brief screening tools for anorexia nervosa and bulimia. Anstine and Grinenko found the following four-question screen to be both sensitive and specific for the identification of older adolescent females with eating disorders: How many diets have you been on in the past year? Do you feel you should be dieting? Do you feel dissatisfied with your body size? Does your weight affect the way you feel about yourself? More than two diets to lose weight in the past year, a perceived need to diet, dissatisfaction with body size, and an effect of weight on selfesteem are associated with anorexia nervosa, bulimia nervosa, and other eating disorders.

If the screening history raises nutritional concerns, the adolescent should be asked to keep a detailed food diary and to meet with a trained dietician who can both obtain and analyze intake data.

Physical Examination Table 4-2 summarizes the physical findings associated with nutrient deficiency and excess. Although these findings may provide important clues to specific nutritional problems, the standard anthropometric measures described next remain the cornerstones of any nutritional assessment. Weight: Body weight responds within days to a change in energy (i.e., kilocalorie) intake and therefore is a shortterm indicator of nutritional status. At every adolescent health care visit, weight should be measured on a calibrated standing scale with the patient barefoot and undressed. The measurement should be plotted on an age- and gender-adjusted weight curve available from the National Center for Health Statistics (http://www.cdc. gov/growthcharts). Height: Until the completion of puberty, growth in height is a long-term indicator of nutritional status. It should be measured at least annually throughout childhood and adolescence and more frequently (every to 6 months) ­during periods of illness or known nutritional deficiency. The most accurate and reliable measurements of height are obtained using a wall-mounted stadiometer. The



Nutrition

21

Table 4-2  Signs of Nutrient Deficiency and Excess on Physical Examination System

Nutrient or Condition

Physical Finding

Mouth

Deficient riboflavin, niacin, biotin, B6, B12, folate, iron, zinc Deficient riboflavin, niacin, biotin, vitamin B6, iron Deficient vitamin C Bulimia nervosa Deficient vitamin A Vitamin A toxicity Deficient thiamin Deficient vitamin B12 Deficient vitamin E Excess copper Deficient vitamin B6, zinc Deficient vitamin C, zinc Deficient niacin Deficient vitamin C Deficient vitamin K Deficient essential fatty acids Protein-energy malnutrition Excess carotenoid Deficient iron, vitamin B12, folate Deficient iron Excess selenium Protein-energy malnutrition Deficient biotin Excess vitamin A Thiamin deficiency Selenium deficiency Niacin deficiency Deficient vitamin D Protein-energy malnutrition Hypocalcemia Deficient vitamin B6, vitamin E, thiamin Excess vitamin B6 Deficient vitamin B12 Deficient thiamin, B6, B12, niacin, biotin Deficient B12, thiamin, niacin

Glossitis Angular stomatitis, cheilosis Gingivitis and gingival bleeding Parotid hyperplasia, dental erosions Night blindness, photophobia, xerosis, corneal ulceration Diplopia Nystagmus, lateral gaze palsy Optic nerve atrophy, blindness Retinitis pigmentosa, visual deficits Kayser-Fleischer ring Seborrheic-like dermatitis Impaired wound healing Rash in sun-exposed areas Perifollicular petechiae, hemorrhage Easy bruising Dry flaky skin Depigmentation Yellow or orange discoloration Pallor (due to anemia) Koilonychia (spoon-shaped nails) Discolored or thickened nails Discoloration, dullness, thinning Alopecia Alopecia Congestive heart failure, tachycardia Cardiomyopathy, heart failure Stomatitis, proctitis, esophagitis Weakness, bone, bony tenderness, fracture Muscle wasting Carpopedal spasm Peripheral neuropathy Peripheral neuropathy Sensory neuropathy Mental status changes, delirium Dementia

Eyes

Skin

Nails Hair

Cardiovascular Gastrointestinal Musculoskeletal

Neurologic

Adapted from Saltzaman E, Mogensen KM: Physical assessment. In Coulston AM, Rock CL, Monsen ER (eds): Nutrition in the Prevention and Treatment of Disease. San Diego, CA, Elsevier, 2001, pp. 48–49.

­ easurement should be plotted on an age- and genderm adjusted height curve available from the National Center for Health Statistics (http://www.cdc.gov/growthcharts). Body Mass Index (BMI): Adiposity can be estimated above the age of 2 years by calculating the BMI as weight in kilograms divided by height in meters squared (kg/m2) or weight in pounds divided by height in inches squared, multiplied by 703 (lbs/in2 × 703).  As described previously for weight and height, BMI should be plotted on an age- and gender-adjusted curve available from the National Center for Health Statistics (http://www.cdc. gov/growthcharts). An adolescent with a BMI greater than the 85th percentile is considered at risk for overweight, and an adolescent with a BMI greater than the 95th percentile is considered at risk for obesity.  Although a high BMI usually indicates excess adiposity, an elite

athlete may have an elevated BMI due to high lean muscle mass and low body fat. Other measurements, such as those described next, are helpful in these circumstances. Waist Circumference and Waist–Hip Ratio: Waist circumference is a reliable test of adiposity in adolescents and adults. Top normal cut-points are 78.0 cm for adolescent females, 83.5 cm for adolescent males, 88.0 cm for adult females, and 102.0 cm for adult males. The waist–hip ratio, calculated as waist circumference divided by hip circumference, provides a reliable estimate of truncal adiposity in adults but does not correlate well with truncal fat mass in children and young adolescents. Complications of obesity are associated with a waist–hip ratio greater than 1.0 in adult men and greater than 0.8 in adult women. Skin Fold Measurements: Skin folds, measured with specialized calipers at the triceps, biceps, ­ subscapular

22

Adolescent Medicine: The Requisites in Pediatrics

area, and abdomen have shown to correlate well with body fat in adults, adolescents, and children. However, the reliability of intra- and inter-observer measurements are low and the technique has only been studied in Caucasian populations.

Laboratory Evaluation The history and physical examination guide the laboratory component of a nutritional assessment. The evaluation of an overweight or obese adolescent is discussed in Chapter 11. Serum levels of specific vitamins or minerals can be measured in adolescents with suspected excessive or deficient intake. In other situations, the laboratory evaluation can identify nutritional problems before clinical findings emerge. Examples include the use of red cell indices to detect iron deficiency anemia or anemia of chronic disease, hypophosphatemia to monitor refeeding after a period of malnutrition, and prealbumin and albumin as indicators of protein and energy intake during the preceding 1- and 3-week periods, respectively.

Nutritional Requirements Definitions In 1989, the United States and Canada adopted a set of nutrient and energy guidelines called the Recommended Daily Allowances (RDAs) and Recommended Nutrient Intakes (RNIs), respectively, in a joint effort to prevent nutritional deficiency across the lifespan. In 1997, a revised set of standards called the Dietary Reference Intakes (DRIs) were adopted to promote lifelong health and prevent nutritionally related deficiency, toxicity, and chronic illness. The DRI consists of four reference values. The Estimated Average Requirement (EAR) is the daily intake required by half the healthy individuals in a given group. The Recommended Dietary Allowance, or updated RDA, is the daily intake required by nearly all the healthy individuals in a group. Adequate Intake (AI) is reported for a nutrient when there is insufficient scientific evidence to support an EAR or RDA. Finally, the Tolerable Upper Intake Level is the highest daily intake that poses no risk of adverse health effects to nearly all healthy individuals in a group. Table 4-3 lists the updated

Table 4-3 Recommended Daily Dietary Allowances (RDAs) or Daily Adequate Intakes* for Selected Nutrients at Ages 9–13 Years, 14–18 Years, During Pregnancy, and During Lactation Ages 9–13 Years Males

Females

Ages 14–18 Years Males

Females

Pregnant

Lactating

Females

Females

Energy (kcal)1 2279 2071 3152 2368 27082 27333 Carbohydrate (g)   130   130   130   130   175   210 Total Fiber (g)    31    26    48    26    28    29 Protein (g/kg)     0.95     0.95     0.85     0.85     1.1     1.3 Vitamin A (μg)   600   600   900   700   750 1200 Vitamin C (μg)    45    45    75    65    80   115 Vitamin D (μg)2   5*   5*   5*   5*   5*   5* Vitamin E (mg)    11    11    15    15    15    19 Thiamin (mg)     0.9     0.9     1.2     1.0     1.4     1.4 Riboflavin (mg)     0.9     0.9     1.3     1.0     1.4     1.6 Niacin (mg)    12    12    16    14    18    17 Vitamin B6 (mg)     1.0     1.0     1.3     1.2     1.9     2.0 Folate (μg) 300 300 400 400 6003 500 Vitamin B12 (mg)   1.8   1.8   2.4   2.4   2.6   2.8 Calcium (mg) 1300* 1300* 1300* 1300* 1300* 1300* Fluoride (mg)   2*   2*   3*   2*   3*   3* Iron (mg)   8   8  11  15  27  10 Magnesium (mg) 240 240 410 360 400 360 Phosphorus (mg) 1250 1250 1250 1250 1250 1250 Selenium (μg)    40    40    55    55    60    70 Zinc (mg)     8     8    11     9    13    14 Adapted from the Reports of Dietary Reference Intakes (DRIs), Food and Nutrition Board,The National Academies of Sciences.  Available at http://www.nap.edu.  Accessed May 17, 2007. * Daily Adequate Intake is shown when there is insufficient data to support RDA. 1 Energy requirement at the median age within the given age range and at an active level of physical activity. 2 2368 during the first trimester; 2708 during the second; 2820 during the third. 3 2698 during the first 6 months; 2768 during the second 6 months. Evidence links low folate intake with neural tube defects in the fetus; therefore it is recommended that all women capable of becoming pregnant consume 400 μg from supplements or fortified foods in addition to intake of food folate from the diet.



Nutrition

RDAs or AIs by age and gender for energy and for select macronutrients, vitamins, minerals, and other food components (fiber).

Table 4-5 Calcium Content of Selected Calcium-Rich Foods Food and Serving Size

Energy Energy, expressed in kilocalories (kcals), is the chemical fuel that drives all physiological functions. The minimum daily energy required to maintain vital body processes, or resting energy expenditure (REE), can be estimated from the individual’s gender, weight, height, and age (Table 4-4). To estimate actual energy expenditure, the REE is multiplied by an average daily activity factor that ranges from 1.0 when asleep to 7.0 for activities such as heavy manual labor, basketball, or soccer. Dietary energy is provided by carbohydrates, protein and fat. The DRIs recommend that carbohydrates (4 kcal/g) make up 45–65% of energy intake; protein (4 kcal/g), 10– 30%; and fat (9 kcal/g), 25–35%. Dietary fat should come primarily from sources of polyunsaturated and monounsaturated fatty acids, such as fish, nuts, and vegetable oils. Trans fats, found in hydrogenated oils used primarily in bakery products, should be avoided altogether because they increase serum levels of low-density lipoproteincholesterol (LDL-C). Dietary intake of total cholesterol, found in animal products, should be limited to 300 mg/day.

Vitamins and Minerals Vitamin and mineral requirements increase during the adolescent years. Although the guidelines are readily met by a well-balanced diet rich in fruits and vegetables, the average adolescent’s intake of several key nutrients is substandard, as described next. Calcium and Vitamin D: Achieving peak bone mass depends on adequate calcium and vitamin D intake during adolescence. Yet the 1999–2000 data from the National Health and Nutrition Examination Survey revealed that neither adolescent males nor females consumed the recommended 1300 mg/day. Median intake is 1081 mg/day for males and 793 mg/day for females. Adolescents who

Table 4-4 The Harris-Benedict Equation for Resting Energy Expenditure, in kcal/day Males

66.47 + 13.75(WT) + 5.0(HT) − 6.76(AGE)

Females

655.1 + 9.56(WT) + 1.85(HT) − 4.68(AGE)

Adapted from Johnson RK,Coward-McKenzie D:Energy requirement methodology. In Coulston AM, Rock CL, Monsen ER (eds): Nutrition in the Prevention and Treatment of Disease. San Diego, CA, Elsevier, 2001, p. 34. WT, body weight in kilograms; HT, standing height in centimeters; AGE, chronological age in years.

23

Dairy Products Yogurt, nonfat plain, 1 cup Milk, skim, 1 cup Swiss cheese, 1 oz. Mozzarella cheese, part skim, 1 oz. Cottage cheese, 1% milk fat, 1 cup Calcium-Fortified Foods Soy milk, calcium added, 1 cup Orange juice, calcium added, 1 cup Total cereal, 1 cup Fruits and Vegetables Collard greens, ½ cup, cooked Figs, dried (5), 3.3 oz. Kale Orange, 1 medium Broccoli, ½ cup, cooked Legumes, Nuts, and Other Tofu, firm (calcium-set), ½ cup Black-eyed peas, 1 cup Navy beans, 1 cup Almonds, ¼ cup Blackstrap molasses, 1 tbsp

Calcium (mg/serving)

452 306 224 207 138 300 200 250 180 135   90   56   36 258 212 128   94 172

U.S. Department of Agriculture,Agriculture Research Service, USDA Nutrient Data Laboratory, 2002. USDA National Nutrient Database for Standard Reference, Release 17. Available at: http://www.nal.usda.gov/fnic/foodcomp. Accessed August 29, 2005.

consume little or no dairy products should be encouraged to choose other calcium-rich foods (Table 4-5) or to take calcium supplements. In addition to low calcium intake, adolescents who do not drink vitamin D–fortified milk or who live in northern latitudes (particularly if their skin pigmentation is dark) are at risk for vitamin D deficiency. Iron: In addition to its transport of oxygen and carbon dioxide within the red blood cells, iron contributes to energy production and immune function. Dietary requirements for iron increase during adolescence because of increased muscle mass and blood volume in males and females and menstrual blood loss in females. Iron-rich foods include meat, spinach, kidney beans, and fortified cereals. Vitamin C can enhance the absorption of non-heme iron from plant sources. Zinc: Zinc is essential for growth, sexual maturation, immune function, and wound healing. Good sources of zinc include animal products such as meats, seafood, eggs, and milk; dried beans; and unrefined cereals.

Nutritional Supplementation In general, all vitamin and mineral needs can be met with a well-balanced diet that includes fruits, vegetables,

24

Adolescent Medicine: The Requisites in Pediatrics

low-fat dairy products, and whole grains. The American Dietetic Association recommends that nutrients for healthy adolescents should come from food rather than supplements. The American Academy of Pediatrics (AAP) agrees, with the exception of fluoride supplementation for children living in areas with nonfluoridated water. The AAP recommends that additional supplementation be considered for adolescents who are neglected or abused, pregnant, chronically ill, and deficient in ­specific food groups or nutrients.

The following general recommendations can be used to guide the nutritional counseling of most adolescents who are seen in the primary care setting: l

l

l

Nutritional Counseling Nutritional counseling ranges from brief endorsements of healthy eating habits to lengthy discussions of malnutrition or disordered eating. In the latter situations, a registered dietician who understands adolescent nutritional needs becomes an important member of the health care team.

l

Explain why good nutrition is important: energy for school, work, sports, and fun; a healthy appearance; growth and pubertal development. Encourage regular meals, especially breakfast. Research shows that adolescent girls who eat breakfast have a higher intake of calcium and fiber and a lower BMI. Promote family meals. Frequency of family meals has been inversely associated with tobacco, alcohol, and marijuana use; low grade-point average; depressive symptoms; and eating-disordered behaviors. Discuss the food pyramid (Figure 4-1). The 2005 version, available at http://www.mypyramid.gov, allows the adolescent to create a personalized set of nutritional recommendations based on age, gender, and activity level. The web site also includes information

Figure 4-1  Food guide pyramid. This is the food pyramid for a 15-year-old female who gets 30–60 minutes of exercise per day, as obtained from http://www.mypyramid.gov., U.S. Department of Agriculture, Center for Nutrition Policy and Promotion, April, 2005.



l l

l

l

l

Nutrition

for health professionals and materials that can be downloaded for use as patient handouts. Explain how to read nutrition labels (Figure 4-2). Discuss serving size. Giving understandable size comparisons may help the adolescent with portion control. For example, 3 oz. of meat is the size of a deck of cards, 1½ oz. of cheese is the size of four stacked dice, and ½ cup of ice cream is the size of a tennis ball. The Department of Health and Human Services posts a wallet-sized card with similar examples at http://hin. nhlbi.nih.gov/portion/keep.htm. Encourage daily exercise. For adolescents who do not play sports, suggest ways to incorporate activity into their daily lives, such as taking stairs instead of the elevator, getting off the bus a few stops early, taking a walk with a friend, or dancing to their favorite music. Consider cultural differences. Food beliefs and practices vary widely among social, religious, and ethnic groups. Help adolescents set specific and obtainable goals to improve their nutrition. Examples include preparing a family meal that is baked or broiled instead of fried; eating breakfast before school; decreasing carbonated beverages by one serving per day; making healthier

25

choices at fast food restaurants; planning healthier snacks; and removing the salt shaker from the table.

Nutrition for Athletes Intense physical activity increases energy and water requirements but rarely increases the need for specific nutrients. Adolescent athletes are aware that nutrition affects performance but are often misinformed about how to optimize their intake. Counseling athletes, families, and coaches about healthy and unhealthy nutritional practices therefore is an essential component of the sports examination. Caloric requirements vary widely by level of training and activity, as well as by gender, body size, body composition, and stage of growth. The energy recommendations shown in Table 4-3 account for some of these variables, but an adolescent athlete whose growth is delayed or whose weight deviates more than expected might require further adjustment of daily kilocalories. Adolescent athletes, parents, and coaches should be reminded that thirst is a late indicator of fluid deficit. For intense physical activity, the athlete should drink 10 to 14 oz. 1 to 2 hours before the event, 10 to 12  oz. 20 to

Sample label for macaroni and cheese

1 Start here

Nutrition Facts Serving Size 1 cup (228g) Servings Per Container 2

Amount Per Serving

2 Check calories

Figure 4-2 

How to read a nutrition label. From U.S. Department of Agriculture and U.S. Department of Health and Human Services, 2000. Dietary Guidelines for Americans, 5th ed., Home and Garden Bulletin No. 232. Washington, D.C., U.S. Government Printing Office. Avail­ able at: http://www.cfsan.fda.gov/~acrobat/foodlab.pdf. Accessed May 17, 2007.

3 Limit these nutrients

4 Get enough of these nutrients

Calories 250

Calories from Fat 110

% Daily Value 6 Total Fat 12g 18% Quick guide Saturated Fat 3g 15% to % DV Trans Fat 3g • 5% or less 10% is low Cholesterol 30 mg 20% Sodium 470mg 10% • 20% or more Total Carbohydrate 31g 0% is high Dietary Fiber 0g Sugars 5g Protein 5g Vitamin A Vitamin C Calcium Iron

4% 2% 20% 4%

* Percent Daily Values are based on a 2,000 calorie diet. Your Daily Values may be higher or lower depending on your calorie needs.

5 Footnote

Calories Less than Total Fat Less than Sat Fat Less than Cholesterol Less than Sodium Total Carbohydrate Dietary Fiber

2,000 65g 20g 300mg 2,400mg 300g 25g

2,500 80g 25g 300mg 2,400mg 375g 30g

26

Adolescent Medicine: The Requisites in Pediatrics

30 minutes before the event, 6 to 12 oz. every 15 to 20 minutes during the event, and 16 to 24 oz. for every pound of weight lost after the event. Cool fluids are best as they are rapidly absorbed and contribute to body cooling. Plain water is generally adequate, unless the event is especially long and intense. For events lasting more than an hour, beverages containing some carbohydrate are recommended. For events lasting more than 3 to 4 hours, beverages containing both carbohydrate and sodium are recommended. Menstruating females involved in endurance sports are at increased risk for iron deficiency and should have a screening hemoglobin and hematocrit performed for anemia. Zinc deficiency often accompanies iron deficiency, and the adolescent should be counseled about good dietary sources of iron and zinc. Many athletes want to lose weight or are encouraged to do so. Restrictive eating is a particular problem among dancers, gymnasts, figure skaters, runners, and wrestlers. All athletes should be screened for disordered eating behavior and should be referred immediately for further evaluation and management if an eating disorder is suspected. Some athletes, usually males, may want to gain weight to improve performance. Care should be taken to ensure that the athlete is gaining lean muscle mass rather than excess body fat and that the increase does not reflect the illicit use of drugs or hormones.

Nutritional counseling should be a routine and repeated component of adolescent prenatal care and should continue after delivery for both mother and baby.

Vegetarianism A well-balanced vegetarian diet can have health benefits, including needed reductions in weight, blood pressure, and serum lipids. It also can increase daily intake of vitamins A, E, C; folate; calcium; iron; magnesium; and fiber. Growth and pubertal development are normal for adolescents on vegetarian diets, so long as adequate nutritional intake is maintained. Understanding the type of vegetarian diet the adolescent follows is crucial for appropriate nutritional counseling. Table 4-6 summarizes the types of foods comprising different vegetarian diets. Detailed information is available from the Vegetarian Resource Center at http://www.vrg.org. The most common micronutrients that are deficient in vegetarian diets are iron and zinc. Plant-based, non-heme iron is not as readily absorbed as the heme iron found in meat, poultry, and fish. Sources of non-heme iron include soybeans, lentils, dried apricots, wheat germ, blackstrap molasses, and fortified cereals. Absorption is enhanced by consuming iron with vitamin C and by cooking with cast-iron cookware. Absorption is inhibited by polyphenols found in coffee and tea, calcium-rich foods, calcium supplements, fiber, and phytates found in whole grains and legumes. Zinc is primarily found in animal products, including dairy products. Legumes, whole grains, nuts, and seeds are rich in zinc but also contain phytates, which limit zinc absorption. As with iron, calcium inhibits zinc absorption and acidic foods enhance absorption. Vegetarians who consume poultry, fish, eggs, and/or dairy products typically have no difficulty meeting nutritional requirements. Vegans can meet protein requirements with soy, nuts, beans, and some grains, but are at risk for vitamin B12 and vitamin D deficiency. Vitamin B12

Nutrition During Pregnancy Nutritional requirements increase during pregnancy and lactation, in both the adolescent and adult female (Table 4-3). A prenatal vitamin and mineral supplement that contains iron and folate (1 mg) should be prescribed for all pregnant and lactating females, as well as for those who are planning to conceive. During pregnancy, the weight gain goal should be 25 lbs. for the overweight or obese adolescent and up to 40 lbs. for the underweight ­adolescent.

Table 4-6 Types of Vegetarian Diets

Semi-vegetarian Lacto-ovo-vegetarian Lacto-vegetarian Ovo-vegetarian Vegan Macrobiotic Raw foodist

Plant-Based

Dairy

Eggs

Seafood

Poultry

Red Meat

+ + + + + Organic Fruit, nuts, seeds

+ + + – – – —

± + – + – – –

± – – – – ± –

± – – – – – –

– – – – – – –



Nutrition

is found naturally only in foods of animal origin, but can be obtained through oral supplements or fortified cereals, soy milk, and rice milk. Some soy and rice milks are fortified with vitamin D; otherwise, it can be obtained through oral supplements. Riboflavin deficiency has been reported with severely restrictive macrobiotic diets but is not a problem with other forms of vegetarianism. Sources of riboflavin include wheat germ, tofu, whole grains, broccoli, spinach, and strawberries. Raw foodist diets limited to fruits, nuts, and seeds are not recommended for adolescents.

 l

l

l

l

l

l

Major Points

b

Physiological and behavioral characteristics of adolescents put them at risk for nutritional inadequacy and disorders. A nutrition assessment should be part of every health maintenance visit. The DRIs provide reference values for evaluating nutrient intake levels both for immediate and longterm health. Variety, moderation, and portion control are central to maintaining healthy eating behaviors. The primary care physician should aid adolescents in generating practical nutritional goals to improve or enhance their diets. Certain groups of adolescents, such as athletes, vegetarians, and pregnant teens, have special nutrition needs that should be addressed early and frequently.

Bibliography Affenito SG, Thompson DR, Barton BA, et al.: Breakfast consumption by African-American and White adolescent girls correlates positively with calcium and fiber intake and negatively with body mass index. J Am Diet Assoc 2005;105:938–945. American College of Sports Medicine; American Dietetic Association; Dietitians of Canada: Joint Position Statement: Nutrition and athletic performance.  American College of Sports Medicine, American Dietetic Association, and Dietitians of Canada. Med Sci Sports Exerc 2000;32:2130–2145.

27

American Dietetic Association: Position of the American Dietetic Association: Food fortification and dietary supplements. J Am Diet Assoc 2001;101:115–125. Anstine D, Grinenko D: Rapid screening for disordered eating in college-aged females in the primary care setting. J Adolesc Health 2000;26:338–342. Assessment of nutritional status. In Kleinman RE (ed): Pediatric Nutrition Handbook, 5th ed. Elk Grove Village, IL, The American Academy of Pediatrics, 2004, pp. 407–423. Bessler S: Nutritional assessment. In Samour PQ, King K (eds): Handbook of Pediatric Nutrition, 3rd ed. Sudbury, MA, Jones and Bartlett, 2005, pp. 12–15. Caloric and selected nutrient values for persons 1–74 years of age: First Health and Nutrition Examination Survey. United States, 1971–1974. Vital Health Stat 11 1979;209:1–88. Cavadini C, Siega-Riz AM, Popkin BM: US adolescent food intake trends from 1965 to 1996. Arch Dis Child 2000;83:18–24. Eisenberg ME, Olson RE, Neumark-Sztainer D, et al.: Correlations between family meals and psychosocial well-being among adolescents. Arch Pediatr Adolesc Med 2004;158:792–796. Harkness LS, Cromer BA: Vitamin D deficiency in adolescent females. J Adolesc Health 2005;37:75. Lucas B, Ogata B: Normal nutrition from infancy through adolescence. In Samour PQ, King K (eds): Handbook of Pediatric Nutrition, 3rd ed. Sudbury, MA, Jones and Bartlett, (eds).: 2005, pp. 108–110. Neinstein LS, Schack LE: Nutrition. In Neinstein LS (ed): Adolescent Health Care: A Practical Guide. Philadelphia, Lippincott Williams & Wilkins, 2002, pp. 170–185. Neovius M, Linne Y, Rossner S: BMI, waist-circumference and waist-hip-ratio as diagnostic tests for fatness in adolescents. Int J Obes (Lond) 2002;29:163–169. Neumark-Sztainer D, Wall M, Story M, et al.: Are family meal patterns associated with disordered eating behaviors among adolescents? J Adolesc Health 2004;35:350–359. Overweight children and adolescents 6–19 years of age, according to sex, age, race, and Hispanic origin: United States, selected years 1963–65 through 1999–2002. Available at:http:// www.cdc.gov/nchs/data/hus/hus04trend.pdf#070. Accessed September 1, 2005. Pereyra LC, Schneider M: Vegetarianism. Adolesc Health Update 2004;17:1–10. Wright JD, Wang C, Kennedy-Stephenson J, et al.: Dietary intake of ten key nutrients for public health, United States: 1999–2000. Adv Data No. 334. Hyattsville, MD, National Center for Health Statistics 2003.

C h Ap t er

5

Introduction Resilience-Based Prevention Evaluation Annual Comprehensive Visit Interim Visit Visit for Violence-Related Injury

Intervention Cognitive Maturity Readiness for Change Social Context Threshold for Fighting

Introduction Violence is the third leading cause of death among U.S. youth aged 14–21 years. Although the primary prevention of violence has become a public health imperative, secondary prevention at the individual level has lagged behind. Clinicians commonly describe inexperience and discomfort with adolescents who are perpetrators or victims of violence. In part, this reflects the limited research on office-based interventions for youth violence.  However, there is an evolving literature on community interventions that can help guide clinicians in their effort to reduce ­violent injury among youth. The strategies offered in this chapter are based on the available evidence. T   he goal is to promote clinician discussion of violence with adolescent patients and stimulate clinician demand for violence prevention strategies that are effective, efficient, and respectful of youth assets and needs. The chapter is divided into three sections. The first approaches violence prevention from the perspective of resilience rather than risk. The second reviews strategies for office-based violence screening. The third section gives specific examples of brief office interventions designed to decrease the likelihood of subsequent violent injury. 28

Approaching Youth Violence in a Clinical Setting Kenneth R. Ginsburg, MD, MEd

Resilience-Based Prevention The classic approach to adolescents at risk for violence is to assess their behaviors and educate them about the associated dangers (Box 5-1). This risk approach may work for youth who are highly motivated to change their behaviors but may frustrate, offend, shame, or alienate those who lack the tools or context for such change. The focus on risk utilizes a deficit model in which individual and environmental problems are highlighted. Although corrective strategies usually are discussed, the adolescent considers these strategies from the perspective of ­inadequacy, or weakness, rather than strength. Proponents of resilience-based prevention believe that it avoids the negative social and psychological consequences of risk-based prevention, boosts adolescent self-efficacy, and encourages an appreciation of youth assets (Box 5-2). The resilience, or positive youth development, paradigm poses the following questions: l

l

l

l

Why do some adolescents from adverse environ­ ments thrive while their peers fail? What are the individual strengths an adolescent can employ to negotiate challenging environments? How can adults help adolescents apply individual strengths in safe, pro-social strategies rather than ­high-risk, survival strategies? What are the contextual supports (e.g., family, school, church, neighborhood) that will protect the adolescent during the transition to pro-social behavior?

The resilience model begins with an appreciation of what adolescents are doing right within their environments. For example, a gang member understands and manifests loyalty. An adolescent who discusses gang participation with a clinician has the capacity and the desire to engage a caring adult. Acknowledging these



Approaching Youth Violence in a Clinical Setting

Box 5-1  Risk Factors for Youth Violence

Box 5-2  Protective Factors Against Youth

Individual Risk Factors

Individual Protective Factors

l l l l l l l

l l l

History of violent victimization or involvement Attention deficits, hyperactivity, or learning disorders History of early, aggressive behavior Involvement with drugs, alcohol, or tobacco Low IQ Poor behavioral control Deficits in social, cognitive, or information-processing abilities High emotional distress History of treatment for emotional problems Anti-social beliefs and attitudes

Family Risk Factors l l l l l l l l l

Authoritarian childrearing attitudes Harsh, lax, or inconsistent disciplinary practices Low parental involvement Low emotional attachment to parents or caregivers Low parental education and income Parental substance abuse or criminality Poor family functioning Poor monitoring and supervision of children Exposure to violence and conflict in the family

Peer/School Risk Factors l l l l l l

Association with delinquent peers Involvement in gangs Social rejection by peers Lack of involvement in conventional activities Poor academic performance Low commitment to school, and school failure

Community Risk Factors l l l l l l

Diminished economic opportunities High concentrations of poor residents High level of transiency High level of family disruption Low levels of community participation Socially disorganized neighborhoods

Available at: http://www.cdc.gov/ncipc/factsheets/yvfacts.htm. Accessed May 17, 2007.

c­ ompetencies early in the conversation may help the ­clinician align with the adolescent. The strength-based approach can be incorporated into daily clinical interactions with youth. When adolescents report violence, they usually do so with some explanation of context. For example, “I punched her because she said....” For the adolescent, the cause is primary and the behavior is secondary. The clinician, however, tends to respond primarily to the behavior and secondarily to the cause. Furthermore, adults rarely ask adolescents for permission before expressing opinions or offering

29

Violence

l l l l

Intolerant attitude toward deviance High IQ or high grade-point average Positive social orientation Religiosity

Family Protective Factors l

l l

l l

l

Connectedness to family or adults outside of the family Ability to discuss problems with parents Perceived parental expectations about school performance are high Frequent shared activities with parents Consistent presence of parent during at least one of the following: when awakening, when arriving home from school, at evening mealtime, and when going to bed Involvement in social activities

Peer/School Protective Factors l l

Commitment to school Involvement in social activities

Available at: http://www.cdc.gov/ncipc/factsheets/yvfacts.htm. Accessed May 17, 2007.

r­ ecommendations. The simple act of recognizing the adolescent’s predicament and strengths conveys respect and trust in the adolescent’s capacity for change. Thus, instead of opening with a statement about the fight, the clinician might respond, “Thank you for sharing this with me. It takes courage to stand up for something you believe in… But I am worried that fighting may get you hurt or get in the way of your success. I would like to be someone who can help you get to a place where it doesn’t happen again and your future is as good as you deserve. Can we talk about this?”

A statement such as this expresses concern without assigning blame. It allows the adolescent to join with the clinician in exploring safer coping strategies through either problem-focused or emotion-focused responses. For example, learning conflict resolution is a safer, problem-focused response to a violent environment than the emotion-focused response of rage. Venting frustration through exercise is a safer, emotion-focused response than fighting. Some adolescents may have the cognitive maturity and impulse control to develop problem-focused responses, whereas others may need to rely on emotionfocused responses that control stress without inflicting risk. In either case, adolescents can learn to ­ recognize

30

Adolescent Medicine: The Requisites in Pediatrics

the emotional and physical discomfort induced by stress and, with guidance, can plan pro-social channels that help relieve the discomfort (Figure 5-1).

Evaluation Annual Comprehensive Visit Screening questionnaires for violence-related attitudes and behaviors exist, but they are neither designed nor validated for use in clinical settings. The comprehensive psychosocial assessment described in Chapter 2 as part of the annual adolescent examination therefore remains the primary means of identifying adolescents who are victims or perpetrators of violence. Before asking personal questions of the adolescent, it helps to explain the reasons for the questions, how the answers will be used, and the confidentiality limits imposed by suicidal, ­homicidal, or abusive behavior. Four components of the comprehensive assessment are central to the identification of adolescents at risk for violence: home safety, relationship safety, substance use, and mental health. Asking the adolescent, “Is home a safe place for you?” can circumvent a crisis before it occurs. Parent–teen conflict occurs in most homes at some time during adolescence, but physical aggression between parent and teen should always raise concern that tempers are flaring out of control. Social support or family therapy can halt the escalation by offering ­coping strategies other than verbal or physical aggression. If the ­ adolescent does not feel physically safe at home, social service should be contacted immediately to help with temporary ­placement until further evaluation is ­completed. Adolescents are also at high risk for partner violence. They may misinterpret pathological control or possessiveness as innocent jealousy. Those who are accustomed to physical aggression as an acceptable coping strategy for anger may not understand that healthier, safer approaches can help them deal with relationship conflict. Questions such as “Does he (she) treat you well?” and “Does he (she) get jealous?” allow discussion of the relationship without assigning blame. Positive coping strategies Stress

Physical and emotional discomfort

Learned response to decrease discomfort

Negative anti-social coping strategies

Drug use and drug dealing are major risk factors for violent injury. Once an adolescent admits to drug use, the following is an important follow-up question: “Some people use drugs for fun, but most people use drugs to forget about some kind of uncomfortable feeling, like being sad, nervous, or stressed. How about you? Why do you use (name of drug)?” Framing the discussion in this manner acknowledges the stress in the adolescent’s life and lets the adolescent know that the negative feelings associated with the substance use will not be ignored. The association of violent injury with mental health disorders is bidirectional. Victims of violent injury are at increased risk for the development of major depressive disorder and post-traumatic stress disorder (PTSD), and perpetrators are more likely to have mental health problems that preceded the violent behavior. Self-inflicted injuries such as nonsuicidal cutting and suicide attempts manifest even stronger associations with underlying mental health problems, such as major depressive disorder and impulsivity. Patients with suicidal ideation or intent who are unable to contract for safety (see Chapter 36) must be held under protective watch until hospital admission or another safe, therapeutic environment can be arranged.

Interim Visit Whether the care is acute or routine, every visit can be used to screen for and educate about violence. The parent who expresses concern about an adolescent’s obsession with violent media or video games may be describing an inappropriate coping strategy in which violence has become escapism, fantasy, and desensitized. The patient so used to violence that it is seen as normative or who sees it as the appropriate way to handle stress or conflict is clearly at risk. A parent who had been disciplined violently may know no other way to raise children and will not be prepared to handle the disagreements of adolescence. The clinician can help adolescents, the parents of adolescents, and adolescents who are parents understand that discipline is meant to teach. It is not intended to punish and should never intend to inflict pain. Relief

Figure 5-1  Building strength through the development of positive coping strategies.



Approaching Youth Violence in a Clinical Setting

In addition to exploring safety at home, the adolescent should be asked questions such as “Do you feel safe at school? Are there many fights at your school? Do people bring weapons to school? What do you do to keep yourself safe?” The adolescent who responds, “I’m fine” or “Don’t worry about me” may be unprepared to divulge his or her behavior or fear of someone else’s behavior. A possible response could be “Is someone watching your back, or do you carry something for protection?” Some youth respond, “No, I can fight for myself. People have learned not to mess with me.” Others divulge gang affiliation or weapon carrying. Many, however, remain silent. If it seems appropriate, ask “Do you think a knife or gun would make you safer? Do you carry one?” An adolescent who carries a weapon often believes that it confers protection without risk and that his or her life is of value and to be protected. Before discussing the high risk of death associated with carrying a weapon, which is essential, the clinician can acknowledge the importance of self-protection to and for the adolescent.

Visit for Violence-Related Injury It is imperative to know whether the adolescent treated for an acute violence-related injury is in a cycle of retaliation. Before the adolescent leaves the health care setting, questions such as the following should be asked: “What is going to happen now? Is this over? Are you going to get even? Are people still after you?” Some adolescents feel compelled to display bravado, even after serious injury; for these youth, avoiding the words “fear,”“afraid,” or “worried” may allow them to share their expectations without threatening their self-esteem. Clinicians are required to report patients who threaten the lives of others to the appropriate law enforcement authorities. Conflict avoidance depends, in part, on understanding one’s threshold for fighting. Adolescent conflict usually progresses through four stages. The first is verbal insult or disrespect directed toward the adolescent. The second is generalization of the insult to the adolescent’s family, friends, gang, etc. The third is invasion of personal space, “getting in my face,” or “stepping up to me.” The fourth is physical contact. Thresholds vary among individuals and across settings for a given individual. For example, an adolescent provoked on a street corner may feel compelled to fight rather than walk away. The same adolescent in an institution with zero tolerance for fighting might walk away, saying “You’re not even worth it.” Asking the adolescent questions such as the following can help identify the threshold for fighting: “What do you usually do when you are really mad or frustrated? Do you get in fights? Are you able to walk away from fights? How do you do that? What makes you mad enough to fight?” Once the threshold is identified, ­strategies can be implemented well before it is reached.

31

Intervention The success of any violence intervention depends on its alignment with the adolescent’s cognitive maturity, readiness for change, social context, and threshold for fighting. Each of these characteristics is discussed next, along with case histories that exemplify interventions matched to specific characteristics.

Cognitive Maturity Cognitive maturation during adolescence involves a gradual transition from concrete to abstract thinking. However, it is always better to deliver information in small, simple bites than to talk beyond the adolescent’s level. For example, consider a discussion about the risks of carrying a gun: possible injury, death, incarceration, etc.—all in the future. Words such as “possible” or “future” are abstractions that may have little meaning to a cognitively immature adolescent who views the world and people as good or bad. Concrete thinkers have difficulty looking beyond actions for underlying motivations and are easily fooled by flattering facades. Abstract thinkers can see shades of gray, consider future consequences, and evaluate underlying motivations. The key to helping concrete thinkers grasp consequences of current behaviors is to break down abstract concepts into multiple concrete steps, delivered one at a time. A question is posed, an appropriate silence ensues, and the adolescent works step-by-step through a realization of consequences. Instead of the lecture-style discussion about the gun noted previously, consider an intervention such as the following: “Let’s pretend that I am you. I have a gun in my right hip pocket. Let’s pretend you are another guy and that you have a gun. We’re in each other’s face, and a conflict is about to happen. I reach into my right hip pocket. What would you do?” In nearly all cases, the adolescent responds, “I would shoot you first.” The clinician can then simultaneously reinforce the teen’s answer and point out the inherent risk: “Exactly. Remember, we are pretending that I am you. Do you see that carrying a gun made you much more likely to be killed?” Breaking down the action in this way may help the adolescent grasp consequences previously ­unconsidered.

Readiness for Change According to the Trans-Theoretical Model of Behavioral Change, an individual’s readiness to shift from negative to positive behaviors progresses through the five stages outlined in Table 5-1. The adolescent in the pre-contemplation stage denies the need for change and has no desire or intent

32

Adolescent Medicine: The Requisites in Pediatrics

Table 5-1 Trans-Theoretical Model of Behavioral Change Pre-Contemplation

Contemplation

Preparation Action Maintenance

Individual has no intention to change or denies need for change. Individual is considering change and is weighing perceived costs and benefits. Individual is actively planning to change. Individual is making an attempt to change. Individual is solidifying change and resisting relapse.

to change. An adolescent who ­perceives gun-carrying as survival cannot yet see the gun as risk and therefore has no reason to relinquish it. If other skills are developed that reduce the sense of vulnerability, the adolescent might progress to contemplation, in which the risk-benefit balance begins to shift. Preparation is actively planning to leave the gun at home, and the action is leaving home without it. Maintenance is the set of ongoing efforts to keep the new behavior intact, such as getting rid of the gun completely.

Social Context An adolescent who agrees with a suggested behavioral change may still worry that the change will be ridiculed or undermined by the peer group. The suggested change therefore should be accompanied by a plan to “save face,” or maintain pride. For example, the adolescent in the midst of escalating gang violence is likely to say that leaving town will be interpreted as cowardice. Asking “How do you think this will play with your friends? Will they back you?” gives the adolescent a chance to think through the peer response. As potential blocks to the change emerge, an alternate strategy can be devised. For example, the adolescent whose safety depends on leaving town can prepare an explanation other than fleeing violence, such as “I had to go down to take care of my grandmother. She’s real sick.” Face-saving maneuvers often involve shifting the blame to parents or disciplinarians. For example, “My mother said if I get suspended one more time, I will…,” or “The principal says if I cut class one more time, he will expel me. That would kill my mother, and you know she has high blood pressure.”

Threshold for Fighting The adolescent’s threshold for fighting can help guide the development of alternate coping strategies. For

example, individuals who answer that name-calling is enough to make them lash out physically are often impulsive and act before they have time to think. Teaching these adolescents about slow, deep breathing and silent counting to 10 may calm them enough to gain time. Others may be able to use humor to help them out of situations. When the name-calling is directed at a relative (e.g., mother) or friend, ask the adolescent, “Does the person know your mother? How will your mother feel if you get killed just because someone called her a name?” Adolescents who report that they are likely to fight when their physical space is invaded can be taught to avoid feeling cornered by turning sideways, keeping a leg extended in front, or sitting down. Those with the highest threshold are unlikely to strike until they have been struck. The safest approach for these youth is to avoid settings where fights are likely to happen, because even bystanders can be drawn into escalating violence.

Preventing Retaliation The good news about an adolescent who communicates a retaliation plan to a clinician is that there is often time for intervention.This situation usually involves planning and, as a result, time for intervention. Working through a visual decision tree exposes the adolescent to consequences previously unconsidered. By acting out different scenarios and writing down possible outcomes, the patient might be better able to consider pro-social rather than anti-social strategies for coping with the anger. For example, consider the decision tree illustrated in Figure 5-2. The patient is a 15-year-old girl seen in the office after a fist fight that began when a classmate insulted her mother. When asked what would happen next, the patient responded, “I’m going to kill her.” When asked how that would make her feel, she answered, “Good.” When asked how long she would feel good, she responded,“All day.” The decision tree led her to consider other consequences of pulling the knife, such as death, ­incarceration, and family grief. Even an adolescent who is speaking of retaliation often wants to avoid fighting but cannot escape the social context in which the fight is expected to happen. In some cases, diverting the energy and attention of their peers can prevent the fight. Ask the adolescent what he or she does together with others out of school, when there is no fighting. For example, if they play basketball or smoke marijuana when there is nothing else to do, teach the adolescent to always carry a basketball. When this fails, teach the adolescent to shift the blame for escape to his or her parents. If the parent receives a call in which the teen uses an agreed-upon code word, it signals the parent to demand that the teen return home immediately. The goals are to provide a strategy that the adolescent will use and to remove the adolescent as soon as ­possible from a ­high-risk setting.



Approaching Youth Violence in a Clinical Setting

You fight, but she uses her knife first

Stabbed in back

You fight, but she uses her knife first

Stabbed in the heart

You fight and kill her

Figure 5-2 

A life-saving decision tree.

Your mom is ashamed

No job

You don’t fight

You have kids

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Major Points

b

Resilience-based prevention begins with an appreciation of youth assets and utilizes these strengths to develop pro-social strategies in response to social stress. Four components of the psychosocial assessment are central to the identification of adolescents at risk for violent injury: home safety, relationship safety, substance use, and mental health. Visits for violence-related injury should always include discussion of planned retaliation. Violence intervention should be adapted to the ­adolescent’s cognitive maturity, readiness for behavioral change, social context, and threshold for ­fighting. The use of a visual decision tree can help ­adolescents consider potential outcomes to fighting that were previously denied.

How long are you happy

33

Maimed and left in a wheelchair

You are killed

Jail 20 years

No education

No children

Die poor, with no family

How long are you angry?

You finish school

Your mom is proud!

Bibliography Blum RW: Healthy youth development as a model for youth health promotion: A review. J Adolesc Health 1996;22:368–375. Centers for Disease Control and Prevention: National wCenter for Injury Prevention and Control Youth Violence Fact Sheet. Available at: http://www.cdc.gov/ncipc/factsheets/yvfacts.htm. Accessed November, 2005. Centers for Disease Control and Prevention: Web-based Injury Statistics Query and Reporting System (WISQARS) [online]. 2004. Available at: http://www.cdc.gov/ncipc/wisqars. Accessed May 17, 2007. Dahlberg LL, Toal SB, Swahn M, et al.: Measuring ViolenceRelated Attitudes, Behaviors, and Influences among Youths: A Compendium of Assessment Tools: 2nd ed., Atlanta, Centers for Disease Control and Prevention, National Center for Injury Prevention and Control, 2005. Ellickson P, Saner H, MgGuigan K: Profiles of violent youth: Substance use and other concurrent problems. Am J Public Health 1997;87:985–991. Sege R, Stringham P, Short S, et al.: Ten years after: Examination of adolescent screening questions that predict future violencerelated injury. J Adolesc Health 1999;24:395–402. Smith C, Carlson BE: Stress, coping, and resilience in children and youth. Soc Serv Rev 1997;June:231–256.



C h Ap t er

6

Introduction Role of the Primary Care Provider Medical Home Advocacy Risk Assessment Monitoring Growth and Development Sexual and Reproductive Health Care Immunizations

Promoting Self-Efficacy

Chronic Health Conditions Maria T. Britto, MD, MPH

The objectives of this chapter are to review the responsibilities of the primary care provider in the care of adolescents with chronic conditions, resources that contribute to a supportive care network, and strategies for promoting the self-efficacy of adolescents with chronic health conditions as they transition to adulthood.

Role of the Primary Care Provider Medical Home

Introduction Chronic health conditions that limit activity or increase health care utilization affect 12% of children and adolescents in the United States. Poverty, developmental delay, and psychiatric illness increase the likelihood of functional limitations which, in turn, reduce quality of life. Recent studies indicate that most individuals with chronic conditions in the United States do not receive appropriate, effective care due to inadequate time and training on the part of clinicians and poor self-management skills on the part of patients. Systems of planned, organized care that link outpatient, inpatient, and rehabilitation services with community supports have been shown to improve health outcomes for patients with chronic health conditions. Box 6-1 outlines the characteristics of a model health care system for adolescents with chronic conditions. The cornerstones of the model, developed by Wagner and refined by a national panel of experts, are organized, efficient systems for the delivery of health care, the management of clinical information, guidelines for decision-making, and supports for self-management. Targets for quality improvement and program evaluation include patient safety, cultural competency, care coordination, and case management. 34

The primary care provider (PCP) plays a pivotal role in the care of adolescents with chronic health conditions. The level of involvement depends, in part, on patient and family preference, the availability of disease-specific sub-

Box 6-1  Characteristics of a Model Health

Care System for Adolescents with Chronic Conditions

Structured, evidence-based care that incorporates guidelines, pathways, and other clinical tools l Clinical information system that monitors health care processes and health outcomes at the individual patient and population levels l Education and support to promote management of the condition by the adolescent and family l Developmental approach that supports transition to adult roles and success in the adult health care system l Active partnership of health care providers, adolescent, and family l Feedback and reminders to health care providers, adolescent, and family l Supportive community services l Adequate payment systems l



Chronic Health Conditions

specialists, and disease severity, but PCP constancy over time offers a medical home for the coordination of comprehensive care. Close, ongoing communication between the PCP, specialty team, community providers, and family has been shown to reduce health care error and cost while improving patient satisfaction and outcome. In addition to coordinating effective care for the chronic condition, PCPs generally assume responsibility for general health care services. In the United States, adolescents as a group receive suboptimal preventive care. Although data are sparse, it appears that adolescents with chronic conditions are even less likely to receive needed preventive care than are those without chronic conditions, despite their more frequent health care contacts. Box 6-2 summarizes the major responsibilities of the PCP to the adolescent and family. The tasks apply broadly to all chronic health conditions and consider current and future developmental needs. Disease-specific management goes hand-in-hand with these broader goals and may fall within the purview of the PCP and/or subspecialist. For example, the PCP may choose to manage asthma alone and co-manage cystic fibrosis. Regardless of the delineation, common goals should be the coordination of disease-specific care and the provision of comprehensive primary and preventive care. The PCP can help prevent duplications and omissions by clarifying the responsibilities of involved providers.

Advocacy The PCP can be invaluable in helping the family identify community-based resources as their child develops (Box 6-3) and in educating parents and adolescents about the

Box 6-2  Role of the Primary Care

Provider in the Care of Youth with Chronic Conditions

l

l

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l

l

l

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Provide planned, comprehensive care for adolescents with common chronic conditions (e.g., asthma, attention-deficit hyperactivity disorder). Provide primary and preventive health care, including anticipatory guidance. Know areas of increased need in preventive care for this population. Know resources available in the community for adolescents and young adults with chronic conditions and disabilities. Coordinate care with specialists and communitybased resources. Prepare the adolescent and family for transition from child-oriented to adult-oriented health care. Assist the adolescent with self-management and with adherence to medical regimens.

35

Box 6-3  Community Resources for Youth

with Chronic Conditions

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l

l

State Bureau of Vocational Rehabilitation The ARC (formerly the Association of Retarded Citizens), (http://www.thearc.org) County and city agencies serving persons with mental retardation, developmental disabilities, and mental health disorders Disease-specific advocacy and support organizations such as the Juvenile Diabetes Research Foundation (http://www.jdrf.org) and Children and Adults with ADHD (CHADD®) (http://www.chadd.org) General family advocacy and referral organizations such as Family Voices (http://www.familyvoices.org)

rights of individuals with disabilities. The federal Indivi­ duals with Disabilities Education Act (IDEA) requires a public school to maintain a written Individualized Educational Plan (IEP) for a student with an eligible learning disability. The IEP should be developed and annually reviewed by parents, student, and school personnel and must include a transitional plan from age 14 years to high school graduation. Section 504 of the Rehabilitation Act requires a written individual health plan (IHP) for students with functional limitations due to physical or mental health conditions. The IHP must provide reasonable accommodations in the school setting for the student, such as mobility assistance, speech therapy, or alternative class schedules (http://www.ideapractices.org).

Risk Assessment Although earlier studies suggested that adolescents with chronic conditions or disabilities were less likely to engage in risk behaviors than those without, more recent studies suggest the reverse. For example, analyses of the National Longitudinal Study of Adolescent Health (ADD Health) revealed that adolescents with asthma were more likely to smoke cigarettes than those without asthma. Consequently, current recommendations call for comprehensive behavioral screening for all adolescents, regardless of their medical histories. Anticipatory guidance about risks for cardiovascular disease, which remains the leading cause of adult morbidity and mortality, is as important for adolescents with chronic conditions unrelated to the heart as it is for other adolescents. Establishing lifelong habits for regular exercise and healthy eating may require adaptive equipment or support services. Diabetes mellitus, systemic corticosteroids, and some psychiatric medications increase the risk of disordered eating and difficulty with weight management. Recognizing these risks, adjusting medications, and involving registered dieticians in the care team can help young patients establish eating and exercise habits that decrease cardiovascular risk.

36

Adolescent Medicine: The Requisites in Pediatrics

Adolescents with and without chronic conditions should be screened through individual and family history for psychiatric illness. There is considerable controversy in the literature about the psychosocial adjustment and potential psychiatric comorbidity of adolescents with chronic conditions. In general, family connectedness, school connectedness, and a supportive health care team appear to promote emotional and behavioral health both in youth with and without chronic conditions. However, some conditions clearly increase the risk of psychosocial difficulty. For example, obesity has been associated with social stigma and more difficulty in school and at work. Severe acne is associated with poor self-esteem and depressive symptoms. The prevalence of these conditions during the adolescent years does not diminish their chronicity and the adverse effects they can have on psychosocial function.

Monitoring Growth and Development Chronic conditions may alter the timing and tempo of growth and pubertal development. For example, spina bifida and McCune-Albright syndrome are associated with the early onset of puberty. More often, chronic ­conditions are associated with pubertal delay (Chapter 10). This may occur as a consequence of poor disease control, as in diabetes mellitus; malnutrition, as in inflammatory bowel disease or cystic fibrosis; or hypogonadotropic hypogonadism due to chronic physiological stress. Anticipatory guidance, evaluation, hormonal intervention when appropriate, and strategies for coping with off­timing should occur during late childhood and throughout puberty.

intercourse, whichever is earlier. For adolescents who cannot tolerate the examination, providers and families will need to balance the value of cervical cancer screening against risks that may be associated with sedation or anesthesia. Sometimes a needed pelvic examination can be performed when the adolescent is sedated for another procedure, such as dental work.

Immunizations Finally, immunizations are particularly important for adolescents with chronic conditions, as they often are at increased risk for diseases that can be prevented by vaccination. Essentially all adolescents can receive killed or recombinant vaccines. At-risk groups, such as those with kidney failure, diabetes mellitus, asthma, and other pulmonary conditions, should receive an influenza immunization each fall. Those who are immunocompromised should not receive live vaccines, such as measles-mumpsrubella (MMR) or varicella.

Promoting Self-Efficacy The development of self-management skills is a critical task for all adolescents, regardless of health status. Box 6-4 outlines factors that support these skills, such as patient and parent training in problem solving. Children and adults with good problem-solving skills have been shown to have higher self-efficacy or confidence in their abilities to manage their own health conditions. A meta-analysis of 32 studies involving children and adolescents with asthma demonstrated that interventions designed to enhance skill as well as knowledge related to asthma improved ­

Sexual and Reproductive Health Care Sexuality and reproductive health present specific c­ hallenges for adolescents with chronic conditions. Cognitive, motor, or social limitations may result in less exposure to peer- and school-based education about the development of secondary sex characteristics, menstruation, and personal hygiene. Parents may be uncertain when or how to broach the subjects with their young adolescents. The PCP can help by providing early counseling and by suggesting strategies for managing personal hygiene as the adolescent grows, menses, etc. Counseling about sexual feelings and behavior is essential for all adolescents and should include discussion of appropriate and inappropriate touching, contraception, and sexually transmitted infection. Asymptomatic adolescents who are not sexually active generally do not require pelvic examination. The American College of Obstetrics and Gynecology recommends that the first examination and Papanicolaou (Pap) test be performed at age 21 years or 3 years after onset of sexual

Box 6-4  Factors That Promote Self-

Management

l

l

l

l

Adolescent and family share responsibility in managing the adolescent’s health. Responsibility adjusts to the developmental needs and changes of adolescence. Strategies are used that are known to be effective in enhancing adolescent self-efficacy, such as the following: l Assessing adolescent and family needs and preferences l Setting specific behavioral goals l Action planning l Problem solving l Motivational interviewing l Active follow-up Peer and community resources are incorporated into a supportive care network.



Chronic Health Conditions

37

Table 6-1  Risk Factors for Self-Management Problems Domain

Risk Factor

Family

Family dysfunction Other activities reduce treatment supervision Low education

Adolescent

Adjustment or coping problems Cognitive impairment Lack of belief in the benefit of treatment Fluctuating course High regimen complexity Side effects of regimen Treatment of asymptomatic disease Cost of medication and co-pays Poor provider–family communication Lack of access to care/inadequate follow-up

Disease and regimen

Health care

self-efficacy, pulmonary function, daily activities, and school attendance. In contrast, interventions that focused on knowledge alone, psychological treatment, or written management plans demonstrated little or no efficacy. Skill development consists of specific learned strategies for success, such as taking medications at the same time each day or parent–teen review of the day’s blood sugar log each evening. Asking “What makes it difficult for you to take your medicine?” can be a first step toward solution. When the patient or family is ready to make a behavior change, helping them set a reachable goal, such as walking 20 minutes per day, may allow them to begin the change process. Concrete, short-term goals that the adolescent believes are achievable are more likely to be successful than larger goals. Although self-management is the ultimate goal for an adolescent with a chronic condition, it involves a process of change rather than a moment of transition. A study of adolescents with diabetes mellitus demonstrated the importance of adjusting the level of responsibility to the adolescent’s maturity and ability to self-manage. Those subjects who were transitioned prematurely to adult care had poorer outcomes than subjects who transitioned later. Until adolescents are ready to manage their health and health care independently, parents should be encouraged to monitor, reinforce positive behaviors, provide consistent consequences for significant negative behaviors, and ignore small infractions that are unlikely to affect outcome. Risk factors for self-management problems are outlined in Table 6-1. For adolescents with numerous risk factors or when simpler, office-based interventions have proven ineffective, a multidisciplinary approach, including persons with expertise in behavior change, should be employed.

 l

l

l

l

Major Points

b

Systems of planned, organized care that link outpatient, inpatient, and rehabilitation services with community support have been shown to improve health outcomes for patients with chronic health conditions. Close, ongoing communication between the PCP, specialty team, community providers, and family has been shown to reduce health care error and cost while improving patient satisfaction and outcome. Adolescents with learning disabilities are eligible for support at school through the federal Individuals with Disabilities Education Act. Those with physical and mental health disabilities are eligible for reasonable accommodations of the school environment through Section 504 of the Rehabilitation Act. Primary and preventive care services should encompass the same domains for youth with and without chronic conditions (e.g., risk behaviors, cardiovascular health, mental health, sexual health, immunizations, growth and development).

Bibliography Bennett DS: Depression among children with chronic medical problems: A meta-analysis. J Pediatr Psychol 1994;19:149–169. Bodenheimer T, Lorig K, Holman H, et al.: Patient selfmanagement of chronic disease in primary care. JAMA 2002; 288:2469–2475. Britto MT, DeVellis RF, Hornung RW, et al.: Health care pre­ ferences and priorities of adolescents with chronic illnesses. Pediatrics 2004;114:1272–1280.

38

Adolescent Medicine: The Requisites in Pediatrics

Centers for Disease Control and Prevention (CDC): Mental health in the United States: Health care and well-being of children with chronic emotional, behavioral, or developmental problems—United States, 2001. MMWR Morb Mortal Wkly Rep 2005;54:985–989.

Newacheck PW, Kim SE: A national profile of health care utilization and expenditures for children with special health care needs. Arch Pediatr Adolesc Med 2005;159:10–17.

Cheng MM, Udry JR: Sexual behaviors of physically disabled adolescents in the United States. J Adolesc Health 2002;31: 48–58.

Rothman AA, Wagner EH: Chronic illness management: What is the role of primary care? Ann Intern Med 2003;138:256–261.

Davidoff AJ: Identifying children with special health care needs in the National Health Interview Survey: A new resource for policy analysis. Health Serv Res 2004;39:53–71. Guevara JP, Wolf FM, Grum CM, et al.: Effects of educational interventions for self management of asthma in children and adolescents: Systematic review and meta-analysis. BMJ 2003;326:1308–1309. Holman H, Lorig K: Patient self-management: A key to effectiveness and efficiency in care of chronic disease. Public Health Rep 2004;119:239–243. Marks R, Allegrante JP, Lorig K: A review and synthesis of research evidence for self-efficacy–enhancing interventions for reducing chronic disability: Implications for health education practice (Part II). Health Promot Pract 2005;6:148–156.

Osterberg L, Blaschke T: Adherence to medication. N Engl J Med 2005;353:487–497.

Suris JC, Michaud PA, Viner R: The adolescent with a chronic condition. Part I: Developmental issues. Arch Dis Child 2004; 89:938–942. Tercyak KP: Psychosocial risk factors for tobacco use among adolescents with asthma. J Pediatr Psychol 2003;28:495–504. Wagner EH, Austin BT, Davis C, et al.: Improving chronic illness care: Translating evidence into action. Health Aff (Millwood) 2001;20:64–78. Ziring PR, Brazdziunas D, Cooley WC, et al.: American Academy of Pediatrics. Committee on Children with Disabilities. Care coordination: Integrating health and related systems of care for children with special health care needs. Pediatrics 1999;104:978–981.

7

C h A pt e r

Introduction Developmental Approach Planning the Transition Tools for Transfer Medical Summary Health Insurance Flexibility

Introduction Advances in health care have led to increased life expectancy for U.S. children with special health care needs (SHCN). More than 90% now survive to adulthood, and an estimated 500,000 transition each year to adult health care. This transition is one of six priority goals for children with SHCN included in Healthy People 2010. In an effort to achieve seamless quality care for young people with SHCN, the federal government and professional organizations have issued guidelines for training and service delivery. The Maternal and Child Health Bureau has charged that all pediatricians should understand the rationale for transition, how to facilitate it, and when it is indicated. The American Academy of Pediatrics,American Academy of Family Physicians, and American College of Physicians have identified the six steps shown in Box 7-1 as critical to a smooth transition. This chapter discusses the process of transition from child-oriented to adult-oriented health care from a patient-centered, or developmental, perspective.

Developmental Approach Transition between the pediatric and adult health care systems should be a process rather than an event. It encompasses all domains of adult life (Box 7-2) but, for the patient with a chronic condition, may hinge on the

Transition to Adult Health Care CoriNne Lehmann, MD, MEd Maria T. Britto, MD, MPH

balance between health and illness. Clinicians can help adolescents assume and parents relinquish responsibility for health management. They also can prepare patients and parents for the cultural and navigational differences

Box 7-1  Critical Steps to Successful

Transition from Child-Oriented to Adult-Oriented Health Care for Youth with SHCN

1. Ensure that an identified clinician assumes responsibility for health care and planning for youth with SHCN during the transition period so as to provide uninterrupted, comprehensive care. 2. Incorporate into physician training and certification the core knowledge and skills to provide developmentally appropriate transition services to youth with SHCN. 3. Maintain a portable, accessible, up-to-date medical summary to facilitate collaboration during the transition. 4. Write a transition plan by age 14 years with the patient and family that outlines services, providers, and payment. Review and update the plan annually and at the time of transfer. 5. Adhere to standard guidelines for primary and preventive care, recognizing that youth with SHCN may require more resources to optimize their health. 6. Ensure the continuation of affordable health insurance that provides appropriate compensation for transition planning and coordination for youth with SHCN. Adapted from American Academy of Pediatrics, American Academy of Family Physicians, American College of Physicians–American Society of Internal Medicine: A consensus statement on health care transitions for young adults with special health care needs. Pediatrics 2002;110(6 Pt 2):1304–1306. Available from: http://aappolicy.aappublications.org/cgi/content/full/pediatrics;110/6/ S1/1304. Accessed May 17, 2007.

39

40

Adolescent Medicine: The Requisites in Pediatrics

Box 7-2  Domains of Transition l l l l l l

Health care Education Vocation and career Social and recreation Housing and transportation Financial management

From Britto MT: Chronic illness in the adolescent. In Osborn L, DeWitt T, First L, et al. (eds): Pediatrics. 1st ed. Philadelphia, Elsevier Mosby, 2004, pp. 1435–1438.

they are likely to experience as they move from childoriented to adult-oriented settings. Adolescents may find adult providers less tolerant of non-adherence, and ­parents may feel less welcome during office visits. Specific issues that should be addressed during the transitional process are outlined in Box 7-3. All of these issues require developmental readiness on the part of the adolescent. Cognitive maturation correlates poorly with chronological age and varies widely among individuals. Furthermore, the ability to abstract into the future, which affects most transitional issues, develops relatively late in the maturational process. Individuals will therefore differ in the ages at which they feel ready to move between health care settings, and a given individual may feel ready to explore some domains or issues (e.g., education) before others (e.g., financial management). Patience with the adolescent and the evolving nature of the transition are key to its ultimate success.

Planning the Transition Pediatricians and parents differ in their perceptions of when to begin teaching children with SHCN about self-management of their health care. The mean age

Box 7-3  Issues to Address During Health

Care Transition

l l

l l l l l

Changes in health insurance Identification of an adult-oriented primary care provider Identification of an adult-oriented subspecialist Need for disability-based services Capability for self-management Skills in health care advocacy Health promotion and disease/injury prevention

From Britto MT: Chronic illness in the adolescent. In Osborn L, DeWitt T, First L, et al. (eds): Pediatrics. 1st ed. Philadelphia, Elsevier Mosby, 2004, pp. 1435–1438.

identified by pediatricians is 9.5 years, whereas that identified by parents is 12 years. Young adolescents describe self-­management as a gradual process in which they are included in decision making and information sharing and their privacy is respected, yet their parents remain informed and involved. Including the older child or young adolescent in a discussion about readiness for self-management may therefore help bridge any gaps that may exist between physician and parent. Mastering normal developmental tasks, such as household chores or an after-school job, can help boost the self-confidence and independence of a young adolescent with SHCN. As the child begins to manifest more autonomy, a clinical checklist updated on each visit prompts review and discussion of the patient’s progress toward self-management and eventual transition. An example of such a checklist is provided in Table 7-1. The National Center on Transitions of the U.S. Department of Health and Human Services provides other checklist examples at its web site entitled “Healthy & Ready To Work” (http:// www.hrtw.org). By middle adolescence, the patient usually assumes responsibility for medications and may be ready to manage refills and appointment schedules. Time alone with health care providers is important during this phase, both to encourage autonomy and to discuss adolescent risk behaviors. Discussions of sexual and reproductive health should occur on nearly every visit with the adolescent and/or parent, depending on the cognitive ­capability and confidentiality requests of the adolescent. Parents of pre-adolescents with mental retardation often are anxious about puberty and can be reassured when clinicians prompt open discussion of what to expect and how to handle issues such as menstrual hygiene. In addition to health care, clinicians should ask patients and parents about educational and vocational planning. SHCN place youth at increased risk for school drop-out and under-employment. Although physicians may not have the expertise or resources to lead this planning, they can steer families toward guidance while adolescents are still in school and considering career options. The Individuals with Disabilities Education Act (IDEA) mandates that schools begin transition planning by age 14 years for any student with an Individualized Education Plan (IEP). The transition plan should counsel the student and/or family about entry into post-secondary education, vocational training, employment, continuing education, and independent living arrangements. Students with impairments that limit at least one major life activity but who do not qualify for school services under IDEA may be entitled to receive assistive technology interventions, supported employment, and transition



Transition to Adult Health Care

41

Table 7-1  Transition to Adult Care Developmental Activities Checklist Please note: The following checklist is related to the child’s developmental age and/or ability. These recommendations are based on issues related to transition to adult health care, career/work, finances, personal goals, and socialization.

Care Coordinator Initials and Date Parents/Guardians Are Informed of the Need to:

Introduced

Reinforced

Completed

N/A

13–18 Years Old: Continue to assist and encourage your teen’s attempts to do self-care. Discuss sexuality with your teen, including how his or her disability may affect future health, career options, marriage, and the ability to have children. Continue to assess your teen’s knowledge and perception of his or her disability while providing additional information as needed. Discuss a plan for adult living, including health care services. Begin to look for adult care providers while allowing your teen to participate in the decisionmaking process. Discuss adult health care financing with your teen. Obtain information about your teen’s state vocational rehabilitation program and school transition program. Apply for SSI and Medicaid, if appropriate, at age 18, if previously denied for financial reasons. Encourage your teen to do volunteer work or find part-time employment. Encourage your teen to speak freely with health care providers. Continue to assign chores and discuss the importance of family responsibilities. Help your teen keep a record of appointments, medications, and medical history (surgeries, treatments, hospitalization, allergies). Allow your teen to make his or her own appointments and call for medication refills and supplies. Teach your teen how to have medical information sent. 19 Years and Older: Assist the young adult with finalizing adult health care financing and insurance options. Identify an adult health care provider with your young adult. Assist your young adult to schedule an appointment with adult care provider while still under pediatric care to ensure that the transfer to adult care will be uninterrupted and complete. Transfer medical record to the adult care provider. Remain as a resource, support system, and safety net for your young adult as he or she assumes the responsibility of self-care. Adapted by permission of Shriners Hospitals for Children. Available from: http://www.hrtw.org/tools/documents/PC1SHC_Chicago_Provider_transition_checklist.doc. Accessed May 17, 2007.

into vocational rehabilitation programs under Section 504 of the Rehabilitation Act. The Americans with Disabilities Act guarantees equal employment opportunities and requires employers to make reasonable ­accommodations for employees with disabilities.

Tools for Transfer The age at which actual transfer of care occurs depends on clinical resources as much as patient readiness. Patients in rural areas or those with rare pediatric conditions may have difficulty identifying adult-oriented providers who are comfortable managing their care. This is one of the most important reasons to begin planning well before the point of desired transfer. The family is ­better

able to explore health care options if time is allowed to do so. Once an adult-oriented clinician is identified for either subspecialty or general medical care, that clinician can help the patient link to others within the adult-care ­network.

Medical Summary A letter from the pediatrician or child-oriented health care provider to the adult-care provider is an important tool for transfer. The letter should summarize the patient’s medical history and should be copied to members of both the pediatric and adult health care teams. In addition to establishing communication and identifying all involved clinicians, the medical summary becomes a portable document for the patient in times of emergency.

42

Adolescent Medicine: The Requisites in Pediatrics

Before preparing a summary, the primary care provider should investigate whether the patient’s subspecialist is preparing a statement, whether there is a transition center at a local medical center that can assist with the transfer of care, and whether an electronic medical record will be used by the adult-care providers. Examples of portable medical summaries are available at http://www.hrtw.org. The usual elements of the summary are the problem list, medications, allergies, procedures, immunizations, feeding plan, and health care providers with contact information. Other items to consider are hospital medical record numbers and admission dates; growth charts; medical equipment specifications; and contact information for pharmacy, guardian, and case manager.

Health Insurance Private parental insurance typically ends at age 18–23 years, depending on student status. Public state funding from Title V Programs for Children with SHCN ends at age 21 years, regardless of student status. Some states offer continued coverage for specific diseases (e.g., sickle cell disease), and some young adults qualify for Supplemental Security Income (SSI) benefits, Medicaid, and/or Medicare. Those already receiving SSI benefits undergo a redetermination process at age 18 years, when eligibility ­ standards in many states change to reflect ability to work. The variability in eligibility and covered services results in confusion and often delay in ensuring a continuation of health insurance. As a result, older adolescents and young adults represent the age groups at highest risk for uninsurance and under-insurance. Review of their policies well before termination allows time to purchase health insurance, seek employment with insurance benefits, arrange short-term Consolidated Omnibus Budget Reconciliation Act (COBRA) coverage through their ­parent’s insurance, or explore their eligibility for public programs.

Flexibility When ill, patients with SHCN may wish to revert back to the pediatric system for care. They may seek the opinions and reassurance of familiar pediatricians and may vacillate between the pediatric and adult systems for a period of time. Patients and their families should be supported by both the pediatric and adult health care teams as they make their way through the final transfer to adult health care. Acknowledgment of successful milestones by the pediatrician, such as high school graduation or the development of a relationship with an adult-care provider, can help bolster the adolescent with SHCN and reassure the parents that their child’s physician remains interested and concerned.

 l

l

l

l

l

Major Points

b

Factors that improve transition to adult care for youth with SHCN include the identification of a clinician who assumes responsibility for care during the transition period; a portable, updated medical summary; and a written transition plan that outlines services, providers, and payment. Private parental insurance typically ends at age 18–23 years, depending on student status, and public state funding from Title V Programs for Children with SHCN ends at age 21 years, regardless of student status. Some young adults qualify for Supplemental Security Income (SSI) benefits and Medicaid ­coverage. Adolescents already receiving SSI benefits undergo a redetermination process at age 18 years to assess their ability to work. SHCN places youth at increased risk for school drop-out and under-employment.The Individuals with Disabilities Education Act (IDEA) mandates that schools begin transition planning by age 14 years for any student with an Individualized Education Plan (IEP).The transition plan should counsel the student and/or family about entry into post-­secondary ­education, vocational training, ­employment, ­continuing education, and independent living arrangements. Students with impairments that limit at least one major life activity but who do not qualify for school services under IDEA may be entitled to receive ­assistive technology interventions, ­supported employment, and transition into vocational ­rehabilitation programs under Section 504 of the Rehabilitation Act. Patients who have transitioned to adult care may wish to consult their pediatricians during times of illness. Pediatric and adult health care teams should work together during these times to reassure patients as they complete the final transfer to adult health care.

Bibliography American Academy of Pediatrics, American Academy of Family Physicians, American College of Physicians–American Society of Internal Medicine: A consensus statement on health care transitions for young adults with special health care needs. Pediatrics 2002;110(6 Pt 2):1304–1306. American Academy of Pediatrics Committee on Children with Disabilities: The role of the pediatrician in transitioning children and adolescents with developmental disabilities and chronic illnesses from school to work or college. Pediatrics 2000;106:854–856. Centers for Disease Control and Prevention, National Institute on Disability and Rehabilitation Research (U.S. Department of Education): Disability and secondary conditions. Healthy



Transition to Adult Health Care

43

People 2010. Available from: http://www.healthypeople.gov/ Document/HTML/Volume1/06Disability.htm. Accessed May 17, 2007.

Newacheck PW, Halfon N: Prevalence and impact of disabling chronic conditions in childhood. Am J Public Health 1998;88: 610–617.

Charvat K, Slap GB: The primary care of adolescents with developmental disorders. Family Practice Recertification 2001; 23:38–44, 47.

Reiss J, Gibson R: Health care transition: Destinations unknown. Pediatrics 2002;110(6 Pt 2):1307–1314.

Geenen SJ, Powers LE, Sells W: Understanding the role of health care providers during the transition of adolescents with disabilities and special health care needs. J Adolesc Health 2003;32:225–233. Healthy & Ready To Work National Center: Healthy and ready to work. Available from: http://www.hrtw.org. Accessed May 17, 2007. Lotstein DS, McPherson M, Strickland B, et al.: Transition planning for youth with special health care needs: Results from the national survey of children with special health care needs. Pediatrics 2005;115:1562–1568.

Reiss JG, Gibson RW, Walker, LR: Health care transition: Youth, family, and provider perspectives. Pediatrics 2005;115: 112–120. White PH: Transition: A future promise for children and adolescents with special health care needs and disabilities. Rheum Dis Clin North Am 2002;28:687–703, viii. White PH: Access to health care: Health insurance considera­ tions for young adults with special health care needs/disabilities. Pediatrics 2002;110(6 Pt 2):1328–1335.



C hApt e r

8

Introduction Definitions Historical Trends in the Rights of Minors Informed Consent Confidentiality and Privacy State Statutes

Introduction Consent, confidentiality, and privacy are the legal cornerstones of adolescent health care. The shift from predominantly two-way communication between the parent and clinician about a child’s health care to three-way communication between the adolescent, parent, and clinician presents new challenges as well as opportunities for a smooth transition to adult care. After centuries in which minors had no status or legal protection, the last 40 years in the United States have witnessed constitutional, federal, and state laws that recognize the rights of minors and promote their access to health care. The objectives of this chapter are to describe the legal context of adolescent care from the clinician’s perspective. The chapter focuses on defining who must consent before a clinician can deliver care to an adolescent and who has the right to information about that care.

Consent, Confidentiality, and Privacy Christopher E. Kraus, JD, MTS Joseph L. Rauh, MD

armed forces confers adult legal status. Other criteria and procedures for emancipation vary among states. HIPAA: The 1996 Health Insurance Portability and Accountability Act (HIPAA) required the U.S. Department of Health and Human Services to develop regulations that control the access to and release of confidential medical information. Informed consent: The legal process in which an individual voluntarily agrees to certain actions based on an understanding of the risks, benefits, and alternatives to those actions.The individual must be capable of understanding the implications at the time consent is granted. Judicial bypass: An alternative procedure to a state’s requirement for mandatory parental involvement for a minor who seeks abortion.The minor can seek a court order allowing her to decide without parental involvement if she is deemed mature enough to do so. Otherwise, the court makes the decision. Mature minor doctrine: A minor is deemed capable of understanding the risks, benefits, and alternatives of specific health services and may consent to those services without parental permission. Minor: A person younger than 18 years in most states of the United States.

Historical Trends in the Rights of Minors Definitions Confidentiality: Protection of shared information against unauthorized disclosure. Emancipated minor: A person younger than 18 years who is legally freed of parental custody, control, and responsibility. In all states, marriage and joining the 44

In the Middle Ages, the term “infant” was applied legally and socially to any individual younger than 21 years. Adult status depended on physical maturity, which was defined as the ability to bear arms and wear armor. From a legal standpoint, “adult” implied a male who was older than 19–21 years of age. Women,children,and ­adolescents had no legal status, rights, or protection.



Consent, Confidentiality, and Privacy

In the United States, parental “ownership” or “sovereignty” of the minor child persisted until the mid-1800s, when the Industrial Revolution drew adolescents from family farms to urban factories. Although these young workers legally remained the property of their parents until age 21, employers assumed increasing control of their lives. Exploitation of minors was common, and harsh penalties were inflicted for disobedience and minor offenses. Immigration and urbanization in the United States during the late 1800s led to increasing public awareness of the need for youth services and protection. State laws began to appear that required school attendance, restricted child labor, separated the juvenile and adult justice systems, protected children from abuse and neglect, and regulated maternal and child health services. New Deal legislation in the 1930s further improved child services and enforced the protection of youth in the workplace. The 1960s and 1970s in the United States witnessed a dramatic change in societal attitudes about children and youth. In 1967 the Supreme Court ruled that juveniles were entitled to due process, and the 26th Amendment to the U.S. Constitution lowered the voting age to 18 years in 1970. Forty-seven of the 50 states ratified the Amendment by lowering the age of majority to 18 years. Although the 1980s–1990s were more restrictive regarding the rights of minors, in 1992 the Supreme Court confirmed an adolescent’s right to abortion. The Court allowed, however, that states could require parental notification prior to adolescent abortion so long as judicial bypass was available.

Informed Consent Informed consent requires the cognitive and emotional capacity to understand the pros and cons of treatment. The law generally assumes that this capacity does not mature before the age of 18 years. However, the laws in all 50 states recognize that exceptions to this generalization exist for certain types of medical care. In most states, minors can provide their own consent for services related to family planning, pregnancy, sexually transmitted infections, human immunodeficiency virus (HIV), sexual assault, substance use, and emergencies. The rationale for selective medical emancipation of minors is two-fold. First, individual privacy is guaranteed by the U.S. Bill of Rights. Second, public health depends on access to and utilization of health care services. Laws that permit minors to consent on their own increase the likelihood that conditions threatening public health, such as sexually transmitted infections, will be diagnosed and treated. Understanding the importance of selective emancipation helps parents to accept it and clinicians to utilize it.

45

Understanding its limitations is reassuring to parents and to adolescents who may not be ready to accept responsibility for all aspects of their health care. Discussing consent and confidentiality with the adolescent and parent on the first visit begins the process of contract negotiation, before a moment of crisis. A welcome letter that explains the office policies regarding a minor’s right to confidential care helps introduce the topic and usually shortens the subsequent discussion. In some offices, the parent or guardian is asked to sign the letter, indicating agreement to abide by the policy. Excerpts from sample welcome letters and parent/clinician contracts are shown in Box 8-1. A common question that arises is whether such contracts are meaningful if statutes already exist that grant minors the right to consent for their own care. In general, Box 8-1 Examples of Clinical Consent

Forms

I authorize CCHMC and the doctor(s) participating in the care of my child to use any treatment or procedures that may be deemed necessary in the medical care and that may be reasonably expected to be part of the normal service. This shall include… preventive medicine procedures. (Excerpt from Cincinnati Children’s Hospital Medical Center’s Consent for Medical Treatment, July, 2004.) I hereby give permission for my child to be seen in the Teen Health Center without being accompanied by a parent or guardian. (Excerpt from Cincinnati Children’s Teen Health Center Authorization Form, July, 2005.) We will spend time talking to your teen about “sensitive” topics, ensuring that your teen is safe and healthy while respecting your family’s values. When we talk to your teen alone, we can keep our discussion confidential (just between your teen and us). Remember, we always encourage open communication between teens and their parents…. Some matters may be discussed that your teen prefers to keep in confidence. We may even provide certain examinations, treatments and medications confidentially. Many years of research have shown that this approach helps build trust between teens and their health care providers, making sure that the teens answer questions honestly in order to keep them healthy… Of course, any serious problems or issues will be shared with the parent/guardian… The Teen Health Center is committed to family-centered health care. We believe that the most important factor in a teen’s life is an involved and caring adult. Staff at the Teen Health Center encourages communication between teens, their families, and other important adults in their lives. (Excerpt from Cincinnati Children’s Teen Health Center Welcome Letter, June, 2005).

46

Adolescent Medicine: The Requisites in Pediatrics

the informed consent agreement between the parties supersedes the statute for several reasons. First, the ­typical statute guarantees that the minor’s right to consent will be upheld in clinical sites that receive public funding but does not guarantee that the right will be upheld in sites that are privately funded. Informed consent agreements, not statutes, define whether minors can exercise the right in such private sites. Second, statutes usually do not guarantee that the right to consent will be accompanied by confidentiality from parents.

that the minor would be ­endangered by the disclosure of information to the parent. Many of the issues of confidentiality and privacy arise when the provider feels conflicting obligations to the adolescent and others who may have a legitimate interest in the adolescent’s well-being, such as family members, case workers, school personnel, and law enforcement officers. In most situations, the clinician can resolve apparent conflicts by encouraging and mediating communication between the adolescent and other parties. In other cases, clinicians can remind parents of agreements to honor confidentiality.

Confidentiality and Privacy Confidentiality in adolescent health care implies that information will not be disclosed to others without the knowledge and agreement of the adolescent. Although the implication is clear, the specifics are often vague and controversial. As noted previously, state statutes guaranteeing a minor’s right to consent for care do not necessarily guarantee that information about that care will be withheld from parents or legal guardians, even when reporting is not essential to the adolescent’s well-being. Mandatory reporting of conditions deemed harmful to the adolescent or others (e.g., physical or sexual abuse, suicidal or homicidal intent) supersedes any pre-existing agreement of confidentiality. These exceptions to confidentiality should be discussed with adolescents prior to treatment and, whenever possible, adolescents should be informed when disclosures are necessary. Clinicians should be cautious about promising more confidentiality than they can provide. For example, adolescents covered by their parents’ health insurance may experience disclosure to parents by insurers that laboratory tests were ­performed or prescriptions were filled. The federal Health Insurance Portability and Account­ ability Act (HIPAA) of 1996 added both weight and complexity to the protection of adolescent confidentiality. The HIPAA Privacy Rule, published in the Code of Federal Regulations, prohibits providers from disclosing the protected health information of a minor to a parent when it is expressly prohibited to do so under state or other law. If the law is silent or unclear about parental access to the information, disclosure depends on the discretion of the provider and any pre-existing agreement between the provider, patient, and parent. HIPAA specifies four situations in which the parent is not entitled to health information about the minor and parental consent is not required for the minor to obtain specific health care services: (1)  a state does not require parental consent for a service and the minor consents to the service; (2)  a court authorizes someone other than the parent to make decisions for the minor; (3)  a parent agrees that the relationship between the minor and the physician shall remain confidential; and (4)  a physician believes

State Statutes The Center for Adolescent Health and the Law (http: //www.adolescenthealthlaw.org) publishes a monograph that reviews state laws pertaining to minor consent. The monograph is updated regularly and organizes the laws by minor group (e.g., emancipated minors) and service type (e.g., treatment of sexually transmitted infection). It includes summary charts of the state laws; discussions of consent, confidentiality, and disclosure; and resource lists.

 l

l

l

l

l

l

Major Points

b

Informed consent requires the capacity to ­understand the risks, benefits, and alternatives for a ­proposed health care service. Most states assume this capacity begins at age 18 years. All states allow selective medical emancipation in which minors can consent to health care services related to family planning, pregnancy, sexually ­transmitted infections, HIV, sexual assault, substance use, and emergencies. Discussing consent and confidentiality with the adolescent and parent on the first visit begins the process of contract negotiation, before a moment of crisis. State statutes typically guarantee that the minor’s right to consent will be upheld in clinical sites that receive public funding but do not guarantee that the right will be upheld in sites that are privately funded. Informed consent agreements, not statutes, define whether minors can exercise the right in such ­private sites. The HIPAA Privacy Rule prohibits health care ­professionals from disclosing the protected health information of a minor to a parent when it is expressly prohibited to do so under state or other law. Health care professionals usually can resolve ­apparent conflicts involving confidentiality and privacy by encouraging and mediating communication between the adolescent and parent(s).



Bibliography 45 C.F.R. 164.202, 502(g); OCR HIPAA Privacy Guidance: Personal Representatives (4 Dec. 2002). Akinbami LJ, Gandhi H, Cheng TL: Availability of adolescent health services and confidentiality in primary care practices. Pediatrics 2003;111:394–401. Anderson SL, Schaechter J, Brosco JP: Adolescent patients and their confidentiality: Staying within legal bounds. Contemp Pediatr 2005;22:54–64. Carey v. Population Services International, 431 US 678 (1977). English A, Ford CA: The HIPAA privacy rule and adolescents: Legal questions and clinical challenges. Perspect Sex Reprod Health 2004;36:80–86. English A, Kenney KE: State Minor Consent Laws: A Summary, 2nd ed. Chapel Hill, NC, Center for Adolescent Health & the Law, 2003. Ford C, Best D, Miller W: Confidentiality and adolescents’ willingness to consent to STD testing. Arch Pediatr Adolesce Med 2001;155:1072–1073. Ford C, English A, Sigman G: Confidential health care for adolescents: Position paper of Society For Adolescent Medicine. J Adolesc Health 2004;35:160–167. Ford CA, Millstein SG, Halpern-Felsher, et al.: Influence of physician confidentiality assurances on adolescents’ willingness to disclose information and seek future health care. JAMA 1997;278:1029–1034.

Consent, Confidentiality, and Privacy

47

In Re Gault, 387 US 1 (1967). Jones RK, Purcell A, Singh S, et al.: Adolescents’ reports of parental knowledge of adolescents’ use of sexual health services and their reactions to mandated parental notification for prescription contraception. JAMA 2005;293:340–348. Minors’ access to reproductive health care in Ohio. Physicians for Reproductive Choice and Health (PRCH), 2005. Available from:http://prch.org/med_ed/tools/minors_access.shtml. Accessed May 17, 2007. Neinstein LS (ed): Adolescent Health Care: A Practical Guide. 5th ed. Philadelphia, Lippincott Williams & Wilkins, in press. Ohio Rev. Code Ann. Section 3709.241 (2005). Planned Parenthood of Central Missouri v. Danforth, 428 US 52 (1976). Reddy DM, Fleming R, Swain C: Effect of mandatory parental notification on adolescent girls’ use of sexual health care services. JAMA 2002;288:710–714. Society For Adolescent Medicine: Position paper on access to health care for adolescents and young adults. J Adolesc Health 2004;35:342–344. Thrall J, McCloskey L, Ettner S, et al.: Confidentiality and adolescents’ use of providers for health information and for pelvic exams. Arch Pediatr Adolesce Med 2000;154: 885–892.



C h A p t er

9

Introduction Importance of Research with Adolescents Challenges of Research with Adolescents Developmental Maturity Informed Consent Confidentiality Compensation Clinician Role and Responsibilities

Ethics, Regulations, and Guidelines of Research with Adolescents Ethical Principles Rules and Regulations Guidelines

Oversight of Human Research Office for Human Research Protection (OHRP) Institutional Review Board (IRB)

Introduction Evidence-based medicine depends on research that is scientifically sound and clinically relevant. Although this book strives to present information that is data-driven, published research on the health and health care of adolescents is sparse compared with that on adults and ­children. For example, little of the research on pharmacokinetics or adherence to pharmacotherapy has included adolescent subjects. Health care providers can help strengthen the scientific base of adolescent medicine through their critical appraisal of the literature, involvement as investigators, and endorsement of adolescent ­participation in research. This chapter addresses six key issues relevant to research involving adolescents: its importance, challenges, ethical principles, regulations, guidelines, and oversight. Under­standing these issues can make adolescent participation in clinical research more comfortable for subjects, families, investigators, and ­clinicians. 48

Adolescent Participation in Research Lorah D. Dorn, PhD

Importance of Research with Adolescents For decades, adult males were the subjects of most clinical research studies. Findings from these studies were applied clinically to women and children, with little empirical evidence that such generalization was safe or effective. An awareness of the associations between age, gender, pathophysiology, and outcome led to increasing research involving women and ­subsequently children. In 1997, the U.S. Congress passed the Food and Drug Administration (FDA) Modernization Act to encourage pediatric testing of new drugs by the pharmaceutical industry. This was followed by the 2002 Best Pharma­ ceuticals for Children Act to promote pediatric testing of already-approved drugs and the 2003 Pediatric Research Equity Act that required pediatric testing of ­certain drugs and biological products. All federal grants supporting clinical studies now require either the inclusion of children or scientific/ethical justification for their exclusion. This justification typically seeks to minimize risk to children by first ­conducting studies in adults.

Challenges of Research With Adolescents Developmental Maturity All aspects of research with adolescents are affected by developmental maturity, from subject recruitment to data collection to the interpretation of results. Clinicians who understand development and apply this knowledge in their care of adolescents are invaluable members of the research team. These clinical investigators generate hypotheses at the bedside, help recruit adolescent subjects, and



Adolescent Participation in Research

conduct data collection with sensitivity to adolescent needs and expectations.

49

Box 9-1  Practical Aspects for Writing and

Obtaining Informed Consent/ Assent for Adolescents

Informed Consent Obtaining informed consent poses a particular challenge in research involving adolescents. Institutional Research Boards (IRBs) usually require that a parent or legal guardian consent to an adolescent’s participation in research. Although adolescent assent, or agreement to participate, often is obtained along with parental consent, only the consent is legally binding. The reason stems from the relatively late development of abstract reasoning during adolescence. Along with the capacity to abstract comes the integration of “hot” and “cool” cognition, as described by Dahl. Hot cognition takes place when emotion is strong. Cool cognition takes place at calmer times, when the adolescent can weigh the positives and negatives of a situation. In a study of subjects aged 7–22 years, knowledge about the research was positively associated with feelings of control, negatively associated with anxiety, and more strongly associated with emotional than cognitive factors. Studies exploring child and adolescent understanding of the informed consent process have yielded conflicting results. When presented with hypothetical situations of research participation, Weithorn and Campbell found that adolescent cognitive capacity by age 14 years resembled that of adults. Susman and colleagues reported that children and adolescents participating in research grasped concrete concepts such as voluntary participation, duration of participation, and benefits to self, but usually did not understand abstract concepts such as the scientific vs. therapeutic purposes of the research. Schwartz found that only 6 of 19 subjects hospitalized to participate in a research study understood the reason for admission. Box 9-1 summarizes practical issues to consider when obtaining parental informed consent and adolescent assent for research participation.

Confidentiality State laws pertaining to adolescent confidentiality in the clinical setting might not apply to the research setting. In fact, most states do not have specific statutes or guidelines pertaining to adolescent confidentiality in the research setting. Yet confidentiality can affect the recruitment, responses, and follow-up of adolescent subjects. When parental consent is required for adolescent participation, one approach is to state in the consent form that information provided by the adolescent will not be shared with the parent. This protection of adolescent confidentiality should be explained verbally to the adolescent and parent prior to obtaining signed

l

l

l

l

l

l

l

l

l

Follow guidelines of your institution. Many have standard paragraphs for certain areas (e.g., risks, confidentiality), and some require an assent form in addition to a consent form. l Write the nonstandardized paragraphs at an age-appropriate level. Many consider the best reading level to be at the 6th- to 8th-grade level. This is true for both parents and adolescents. l Often IRBs or web sites will have glossaries of terms used to explain standard medical procedures. Utilize word processing packages that offer options to check readability scores (e.g., Flesch-Kincaid Grade Level Scoring). If the protocol is complex, consider using a chart or flow diagram to describe the timeline and procedures. Prior to IRB submission, have a lay person read your consent form to see whether he or she understands what is being done in the protocol. If your protocol includes a wide age range of adolescents (e.g., 10–18 years), have adolescents of different ages within the range read the form prior to use. Consider sending the consent form home prior to explaining the protocol and obtaining consent. When obtaining consent/assent from adolescents and/or parents, reiterate issues that could be problematic for an adolescent (e.g., exceptions to confidentiality in cases of certain dangerous behaviors and pregnancy tests, parent’s knowledge of study results). Reiterate that participation is voluntary. Offer opportunities for questions. Consider asking the adolescent questions to determine comprehension. If the study involves a patient, be certain the adolescent and parent understand the difference between clinical care and research procedures.

informed consent and should be reiterated at each ­follow-up research visit. As in the clinical setting, confidentiality should not be assured or upheld when protection from harm becomes an issue for the adolescent (e.g., suicidal ideation, abuse) or others (e.g., homicidal ideation). Exceptions to confidentiality should be explained to adolescents and parents during the consent process and written into the consent form. The research protocol should also include the steps to be taken if incidents such as these arise during the study. The life-threatening nature of these incidents demands adherence to protocol even though the data collected may be adversely affected. For example, when Lothen-Klein and colleagues were required to breach confidentiality regarding suicide intent, the proportion of

50

Adolescent Medicine: The Requisites in Pediatrics

subjects reporting intent dropped from 8% before the ­disclosure to 1% after the disclosure.

Box 9-3  Recommendations for

­ ompensation of Children and C Adolescents

Compensation Compensation to adolescents for their participation in research raises controversial questions about the type of compensation (e.g., monetary, vouchers, gift certificates), the amount, and real or perceived coerciveness on the part of investigators. To help guide decisions about subject compensation, the Intramural Program of the National Institutes of Health developed a standardized compensation scale that suggests $20 for the first hour or part of the study and $10 per hour or part thereafter, adjusted for the level of inconvenience. Boxes 9-2 and 9-3 summarize guidelines developed by the Institute of Medicine for the compensation of research subjects who are minors.

Clinician Role and Responsibilities The role and responsibilities of a clinician can be confusing to an adolescent when that clinician also functions as an investigator. The IRB may recommend that someone other than the clinician discuss the research participation and informed consent with the adolescent and guardian. This suggestion is congruent with the recommendations of the 1964 Declaration of Helsinki.

Box 9-2  Compensation of Adolescents

Participating in Research

 

 

Institute of Medicine, Field MJ, Behrman RE (eds): Ethical Conduct of Clinical Research Involving Children. Washington, D.C., National Academies Press, 2004. Reproduced with permission from National Academies Press.

Ethics, Regulations, and Guidelines of Research with Adolescents Ethical Principles The last 30 years have witnessed a steady increase in federal regulations pertaining to the ethical conduct of human research. In 1974, the U.S. Congress established the National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research. The Belmont Report, issued by this Commission in 1979, remains the most widely cited statement of ethical principles for the protection of human subjects. Box 9-4 summarizes the five key principles defined by The Belmont Report: respect for persons, beneficence, nonmaleficence, proportionality, and justice. These principles hold for all human subjects, regardless of age.

Rules and Regulations

Institute of Medicine, Field MJ, Behrman RE (eds): Ethical Conduct of Clinical Research Involving Children. Washington, D.C., National Academies Press, 2004. Reproduced with permission from National Academies Press.

Following publication of The Belmont Report, the U.S. Department of Health and Human Services (DHHS) developed regulations for research with human subjects that were included in Title 45, Part 46 of the Code of Federal Regulations. Subsequent changes to Part 46 included the addition of subparts addressing specific concerns for vulnerable populations. Subpart D pertaining to children and adolescents (see below) was added in 1983 and revised in 1991. Consent and Assent: Federal regulations specify the elements of informed consent that are required for DHHSrelated research (Box 9-5). However, investigators should



Adolescent Participation in Research

Box 9-4  Ethical Principles for Conduct-

ing Research

RESPECT FOR PERSONS: Duty to respect the selfdetermination and choices of autonomous persons, as well as to protect persons with diminished autonomy (e.g., young children, mentally retarded persons, and those with other mental impairments). BENEFICENCE: Obligation to secure the well-being of persons by acting positively on their behalf and, moreover, to maximize the benefits that can be attained. NONMALEFICENCE: Obligation to minimize harm to persons and, wherever possible, to remove the causes of harm altogether. PROPORTIONALITY: Duty, when taking actions involving risks of harm, to balance risks and benefits so that actions have greatest chance to result in the least harm and the most benefit to persons directly involved. JUSTICE: Obligation to distribute benefits and burdens fairly, to treat equals equally, and to give reasons for differential treatment based on widely accepted criteria for just ways to distribute benefits and burdens. Fletcher JC, Dorn LD, Waldron P: Ethical considerations in pediatric oncology. In Pizzo PA, Poplack DG (eds): Principles and Practice of Pediatric Oncology. Philadelphia, Lippincott-Raven, 1997. Reproduced with permission from Lippincott Williams & Wilkins.

follow institution-specific guidelines when preparing consent forms because the content and language of each element can be specified by the individual IRB. Although parents typically provide consent for their adolescents’ research participation, many adults are uninformed about the participation and do not understand terms such as randomization or placebo. Understanding has been shown to improve with the use of simple, brief documents; understandable language written at an appropriate reading level; the involvement of another family member in the consent process; sending the consent document home prior to initiation of the research protocol; provision of videotaped information; and face-to-face time. If a parent consents but the adolescent objects to participation, the objection should be binding unless the research intervention directly benefits the adolescent and is unavailable outside the research context. A 1983 modification to the regulations requires the IRB to assure that provisions for child/adolescent assent are in place, unless the child/adolescent is incapable of providing it or there is no direct benefit. A more recent recommendation regarding child/adolescent assent, issued by the Institute of Medicine, is shown in Box 9-6. Additional federal guidelines exist for obtaining informed consent when the research involves minors who are incarcerated, wards of the court, subject to shared parental custody, or in foster care.

51

Box 9-5  Elements of Informed Consent 1. State and describe: a.  Research or nature of study b.  Purpose of study c.  Duration of participation d.  Procedures to be followed e.  Which procedures are experimental 2. Describe: a.  Reasonably foreseeable risks b.  Discomforts 3. Describe: a.  Benefits to the subject b.  Benefits to others 4. Disclose alternative procedures or treatments 5. Describe confidentiality of records identifying the subject 6. Explain if the project involves more than minimal risk: a.  Policy on compensation for injuries due to research b.  Availability of medical treatment for such injuries c.  Source of further information 7. Explain: a.  Whom to contact for questions about the research b.  Whom to contact in event of research injury 8. State: a.  Participation is voluntary b.  No loss of benefits on withdrawal c. May withdraw at any time Fletcher JC, Dorn LD, Waldron P: Ethical considerations in pediatric oncology. In Pizzo PA, Poplack DG (eds): Principles and Practice of Pediatric Oncology. Philadelphia, Lippincott-Raven, 1997. Reproduced with permission from Lippincott Williams & Wilkins.

Schools: Research conducted within a school often allows passive parental consent, in which a letter is sent home describing the study and informing the parent that the adolescent will participate unless the study personnel receive a written parental response stating otherwise. According to the Pupil Rights Amendment (i.e., Hatch Amendment), federally funded research requires active parental permission if questions focus on political affiliation; mental and psychological problems; sexual behavior and attitudes; illegal, antisocial, self-­incriminating, or demeaning behavior; critical appraisals of other individuals with whom respondents have close family relationships; legally recognized privileged or analogous relationships, such as those of lawyers, physicians, and ministers; religious practices, affiliations, or beliefs of the student or student’s parent; or income. The Congressional No Child Left Behind Act allows parental notification and inspection of surveys that are created by third ­ parties and intended for ­student completion.

52

Adolescent Medicine: The Requisites in Pediatrics

Box 9-6  Recommendations for Obtain-

ing Child/Adolescent Assent

Box 9-7  Levels of Research That Can Be

Approved by the IRB for Child and Adolescent Research Participation

     

 

 

 

 

Institute of Medicine, Field MJ, Behrman RE (eds): Ethical Conduct of Clinical Research Involving Children. Washington, D.C., National Academies Press, 2004. Reproduced with permission from National Academies Press.

Level of Risk: A study is considered minimal risk if the likelihood and magnitude of the possible harm or ­discomfort is no greater than that encountered in routine life. The IRB can only approve research with children if the risk/benefit category is assigned at levels 1 through 3 of 4 (see Box 9-7). If it cannot be approved by the IRB, the study may be approved by an expert panel convened by DHHS, followed by an opportunity for public review and comments. Waiver of Parental Consent: Section 46.408(c) of the Code of Federal Regulations allows an IRB to waive parental consent if the following conditions are met: (1) the research involves no more than minimal risk; (2) the waiver or alteration will not adversely affect the rights and welfare of the subjects; (3) the research could not be conducted without the waiver or alteration; and (4) whenever appropriate, the subjects will be provided with additional pertinent information after ­participation. Few, if any, states have laws regarding the participation of minors in research. Consequently, IRBs frequently base decisions about consent for research participation on state laws pertaining consent for clinical care. Many states allow adolescents to receive care without parental consent for sexually transmitted infections, pregnancy, family planning, substance use, and mental health disorders. Inves­ tigators should be familiar with state-specific laws

 

Institute of Medicine, Field MJ, Behrman RE (eds): Ethical Conduct of Clinical Research Involving Children. Washington, D.C., National Academies Press, 2004. Reproduced with permission from National Academies Press.

because there is considerable variability across states regarding allowable conditions, procedures, and ages of treatment. Box 9-8 summarizes recommendations of the Institute of Medicine (IOM) regarding parental consent for the research participation of children and ­adolescents.

Guidelines A number of professional organizations have issued consensus statements regarding research with adolescents (see Box 9-9). In 2004, the IOM published recommendations for conducting research with children and adolescents. Box 9-10 summarizes the IOM guidelines for investigators pertaining to ethical conduct in pediatric research.



Adolescent Participation in Research

Box 9-8  Recommendations of the

Institute of Medicine Regarding Parental Consent for the Research Participation of Children and Adolescents

53

Box 9-10 Key Responsibilities of Investi-

gators for the Ethical Conduct of Clinical Research ­Involving Infants, Children, and Adolescents

Institute of Medicine, Field MJ, Behrman RE (eds): Ethical Conduct of Clinical Research Involving Children. Washington, D.C., National Academies Press, 2004. Reproduced with permission from National Academies Press.

Box 9-9  Professional Organizations

Providing Guidelines for Conducting Research with Children and/or Adolescents

Institute of Medicine, Field MJ, Behrman RE (eds): Ethical Conduct of Clinical Research Involving Children. Washington, D.C., National Academies Press, 2004. Reproduced with permission from National Academies Press.

Oversight of Human Research Office for Human Research Protection (OHRP) The federal OHRP oversees all research involving human subjects that is funded or conducted by DHHS. The responsibilities of OHRP include the development of

54

Adolescent Medicine: The Requisites in Pediatrics

c­ riteria for the protection of human subjects; the approval of institutional assurances of compliance on DHHSrelated research; clarification and guidance about the involvement of human subjects in research; the development and implementation of educational programs and resource materials; and the enhancement of human ­subject protection.

Institutional Review Board (IRB) The IRB is an administrative body that is designed to protect the rights and welfare of individuals who are approached for research participation, as well as individuals who are participating in research. The IRB has the authority to approve, disapprove, and regulate all research within an institution based on the federal guidelines mentioned previously. An IRB may exist within one institution (e.g., university, hospital, medical center) and serve only that institution, or it may exist within the private sector and serve many institutions. Different interpretation and application of the federal



Major Points

b

Evidence-based health care for adolescents depends on research with adolescents that is scientifically sound and clinically relevant. l All federal grants supporting clinical studies now require either the inclusion of children or scientific/ ethical justification for their exclusion. l Most IRBs require signed informed consent from a parent or legal guardian for the research participation of an adolescent minor. l Confidentiality as defined by state law for the clinical setting might not apply to the research setting. In fact, most states do not have specific statutes or guidelines pertaining to adolescent confidentiality in the research setting. l To avoid role confusion, the adolescent’s clinician should not recruit or enroll that adolescent in his or her own clinical research study. l Subpart D of Title 45, Part 46 of the Code of Federal Regulations pertains to regulations for research involving children and adolescents. l An IRB may waive parental consent if the research involves no more than minimal risk, will not adversely affect the rights and welfare of the subjects, and could not be conducted without the waiver or alteration. l The Office for Human Research Protection oversees research involving humans at the federal level. The IRB implements federal regulations and oversees research involving humans at the institutional level. l

regulations across IRBs result in different allowable research practices across institutions. For example, some institutions never allow waiver of parental consent despite federal regulations allowing it in certain circumstances. Bibliography American Academy of Pediatrics Committee on Drugs: Guidelines for the ethical conduct of studies to evaluate drugs in pediatric populations. Pediatrics 1995;95:286–294. American College of Obstetricians and Gynecologists: Guidelines for adolescent health research: Committee opinion #302. Obstet Gynecol 2004;104:899–901. American Psychological Association: Ethical principles of psychologists and code of conduct. Am Psychol 2002;57: 1060–1073. Caskey JD,Rosenthal SL: Conducting research on sensitive topics with adolescents: Ethical and developmental consideration. J Dev Behav Pediatr 2005;26:61–67. Dahl RE: Adolescent brain development: Vulnerabilities and opportunities. In Dahl RE, Spear LP (eds): Annals of the New York Academy of Sciences. New York, New York Academy of Sciences, 2004 (Vol. 1021). Dorn LD, Susman EJ, Fletcher JC: Informed consent in children and adolescents: Age, maturation and psychological state. J Adolesc Health 1995;16:185–190. English A: Guidelines for adolescent health research: Legal perspectives. J Adolesc Health 1995;17:277–286. English A, Kenney KE: State Minor Consent Laws: A Summary. Chapel Hill, NC, Center for Adolescent Health and the Law, 2003. Fletcher JC, Dorn LD, Waldron P. Ethical considerations in pediatric oncology. In Pizzo PA, Poplack DG (eds): Principles and Practice of Pediatric Oncology. Philadelphia, LippincottRaven, 1997. Flory J, Emanuel E: Interventions to improve research participants’ understanding in informed consent for research: A systematic review. JAMA 2004;292:1593–1601. Gallin JI: Principles and Practice of Clinical Research. San Diego, CA, Academic Press, 2002. Hurley JC, Underwood MK: Children’s understanding of their research rights before and after debriefing: Informed assent, confidentiality, and stopping participation. Child Dev 2002;73:132–143. Institute of Medicine, Field MJ, Behrman RE (eds): Ethical Conduct of Clinical Research Involving Children. Washington, D.C., National Academies Press, 2004. Lothen-Kline C, Howard DE, Hamburger EK, et al.: Truth and consequences: Ethics, confidentiality, and disclosure in adolescent longitudinal prevention research. J Adolesc Health 2003;33:385–394. Miller VA, Drotar D, Kodish E: Children’s competence for assent and consent: A review of empirical findings. Ethics Behav 2004;14:255–295.



Adolescent Participation in Research

55

National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research: The Belmont Report. Washington, D.C., U.S. Food and Drug Administration, 1979.

Santelli JS, Smith RA, Rosenfeld WD, et al.: Guidelines for adolescent health research. A position paper of the Society for Adolescent Medicine. J Adolesc Health 2003;33:396–409.

National Commission for the Protection of Human Subjects of Biomedical and Behavioral Research: Report and Recommendations. Research Involving Children. DHEW Publication No. OS 77–0004. Washington, D.C., U.S. Govern­ ment Printing Office, 1977 (Vol. 1).

Schwartz AH: Children’s concepts of research hospitalization. N Engl J Med 1972;287:589–592. Society for Adolescent Medicine: Guidelines for adolescent health research. J Adolesc Health 1995;17:264–269.

Ondrusek N, Abramovitch R, Pencharz P, et al.: Empirical examination of the ability of children to consent to clinical research. J Med Ethics 1998;24:158–165.

Society for Research in Child Development: Ethical standards for research with children. In SRCD Directory of Members. Ann Arbor, MI, Society for Research in Child Development, 1996. Susman EJ, Dorn LD, Fletcher JC: Participation in biomedical research: The consent process as viewed by children, adole­ scents, young adults, and physicians. J Pediatr 1992;121:547–552. Tait AR, Voepel-Lewis T, Malviya S: Do they understand? (Part II): Assent of children participating in clinical anesthesia and surgery research. Anesthesiology 2003;98:609–614. U.S. Department of Health and Human Services: Protection of human subjects: General requirements for informed consent. Title 45, Code of Federal Regulations, Part 46.116, 1983. U.S. Department of Health and Human Services. Title 45, Code of Federal Regulations, Part 46. Subpart D: Additional protection for children involved as subjects in research. Washington, D.C., Office of Federal Register 1983;48:9818.

Paasche-Orlow MK,Taylor HA, Brancati FL: Readability standards for informed-consent forms as compared with actual readability. N Engl J Med 2003;348:721–726.

Weithorn LA, Campbell SB: The competency of children and adolescents to make informed treatment decisions. Child Devel 1982;53:1589–1598.

Petersen AC, Leffert N: Developmental issues influencing guidelines for adolescent health research: A review. J Adolesc Health 1995;17:298–305.

World Medical Association: Declaration of Helsinki. Br Med J 1996;313:1448–1449.

National Institutes of Health: Protomechanics: A Guide to Preparing and Conducting a Clinical Research Study. Bethesda, MD, National Institutes of Health. Available from: http://www.cc.nih.gov/ccc/protomechanics/. Accessed May 17, 2007. Noll RB, Zeller MH,Vannatta K, et al.: Potential bias in classroom research: Comparison of children with permission and those who do not receive permission to participate. J Clin Child Psychol 1997;26:36–42. Olds RS: Informed-consent issues with adolescent health behavior research. Am J Health Behav 2003;27(Suppl 3): S248–S263.

Rogers AS, Kinsman SB, Santelli JS, et al.: Code of research ethics: A position paper of the Society for Adolescent Medicine. J Adolesc Health 1999;24:277–282.

Common Medical Problems

Pa r t

II

57

C h Ap t e r

10

Introduction Definitions Epidemiology Pathophysiology Constitutional Delay of Puberty Other Causes of Functional Hypogonadotropic Hypogonadism (FHH) Structural Hypogonadotropic Hypogonadism Hypergonadotropic Hypogonadism

Evaluation Management

Introduction This chapter reviews the definitions, causes, evaluation, and management of puberty that is delayed in onset or stalled in progression. It does not discuss precocious puberty or premature adrenarche, which presents in young children. Common conditions associated with normal puberty are discussed elsewhere in this book, such as anovulation due to gynecologic immaturity in Chapter 22, gynecomastia in Chapter 1, and acne in Chapter 15. The primary objectives of this chapter are to differentiate normal from abnormal puberty during the adolescent years and to facilitate the identification and treatment of conditions interfering with normal pubertal progression.

Definitions Constitutional delay of puberty: The lack or late appearance of secondary sexual characteristics,delayed skeletal maturation as measured by the bone age, and delayed adrenarche as measured by serum concentrations of adrenal androgens.

Delayed Puberty Gail B. Slap, MD, MS Frank M. Biro, MD

Delayed puberty: The lack of or late appearance of secondary sexual characteristics by that chronological age at which the characteristics appear in 95% of the population. In the United States, standards published by the National Center for Health Statistics defines delayed puberty as the absence of breast development or pubic hair by age 13 years in girls and the absence of genital development or pubic hair by age 14 years in boys. Eunuchoidal habitus refers to an arm span that exceeds height by more than 5 cm. It is usually due to hypogonadism with delayed epiphyseal closure of the long bones. Expected adult height: Falls within 1.5 standard deviations of the mid-parental height, corrected for gender. It is determined for males by adding 6.5 cm and for females by subtracting 6.5 cm from midparental height. Primary hypogonadism refers to diseases of the ovaries or testes that result in decreased secretion of estrogen or testosterone and high serum concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH). Secondary hypogonadism refers to impaired secretion of either pituitary gonadotropins (i.e., FSH and LH) or hypothalamic gonadotropin-releasing hormone (GnRH). Secondary sexual characteristics refer to breast development and pubic hair growth in females and to genital development and pubic hair growth in males. Tanner staging is based on these characteristics, although testicular volume is a more accurate measure of male development than the Tanner genital stage. Short stature: A height below the 3rd percentile for ­individuals of that sex and chronological age in the ­population.

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60 Adolescent Medicine: The Requisites in Pediatrics

Epidemiology By definition, delayed puberty occurs in 5% of the population. Constitutional delay accounts for more than 50% of all cases, with a 2:1 ratio of males to females. A family history of delayed puberty is twice as likely in adolescents with constitutional delay as in those with normal puberty, and inheritance patterns suggest ­autosomal dominance with incomplete penetrance. Approximately 20% of delayed puberty is due to functional hypogonadotropic hypogonadism, in which puberty is delayed in onset but occurs spontaneously and progresses normally once begun. Permanent ­hypogonadotropic or hypergonadotropic hypogonadism accounts for 25% of cases (see Box 10-1). Box 10-1  Causes of Delayed Puberty Hypergonadotropic Hypogonadism (high FSH and LH)

Congenital   Turner syndrome   Klinefelter syndrome  Anorchia Acquired   Chemotherapy  Radiation therapy   Trauma  Autoimmune or infectious Hypogonadotropic Hypogonadism (low to normal FSH and LH)

Congenital  Isolated GnRH deficiency    Kallman syndrome (with anosmia)   Laurence-Moon syndrome Bardet-Biedl syndrome    Prader-Willi syndrome (with obesity)  Deficiencies of GnRH and other anterior pituitary hormones Acquired   Functional gonadotropin deficiency    Constitutional delay   Systemic illness (e.g., inflammatory bowel disease)   Malnutrition, weight loss (e.g., anorexia nervosa, starvation)   Excessive exercise    Hypothyroidism    Hyperprolactinemia    Hypercortisolism  Structural gonadotropin deficiency   Tumor (e.g., craniopharyngioma, germinoma, astrocytoma)   Infiltrative (e.g., histiocytosis, hemochromatosis, granulomatous)    Pituitary infarction

Short stature is not present in all adolescents with delayed puberty, and delayed puberty does not occur in all adolescents with short stature. By definition, short stature affects 3% of the population. The most common causes after infancy are genetic (i.e., familial) and constitutional delay of growth. Genetic short stature is associated with a bone age that is consistent with chronological age and predicts adult short stature. In contrast, constitutional delay is associated with a bone age that is delayed for chronological age and predicts normal adult stature.

Pathophysiology The age thresholds for defining delayed puberty in the United States are based on analyses of the 1988–1994 National Health and Nutrition Examination Surveys (NHANES) III, the 1988–1994 Hispanic Health and Nutrition Examination Surveys (HHANES), and the 1997 Pediatric Research in Office Settings (PROS) study (see Chapter 1). By age 13 years, at least 95% of white, black, and Mexican-American girls have achieved Tanner Stage 2 for breast and/or pubic hair development. By age 14 years, at least 95% of white, black and MexicanAmerican boys have achieved Tanner Stage 2 for genital and/or pubic hair development. Because there is less variability by race/­ethnicity in the 95th percentile ages than in the mean ages, delayed puberty in the United States typically is defined as the absence of breast development or pubic hair by age 13 years in girls and the absence of genital development or pubic hair by age 14 years in boys. The pathophysiology of delayed puberty involves decreased secretion of GnRH (i.e., hypogonadotropic hypogonadism) in at least 85% of cases. The cause may be functional without an apparent structural defect of the hypothalamus (e.g., constitutional delay and chronic illness), structural without an apparent genetic defect (e.g., craniopharyngioma), or genetic (e.g., Kallman syndrome). Differentiation of these categories can be difficult because all involve decreased serum levels of GnRH, FSH, LH, estrogen, and testosterone. The underlying pathologies, diagnoses, and presentations are discussed next, followed by a review of the most common causes of hypergonadotropic hypogonadism (i.e., Klinefelter syndrome and Turner syndrome).

Constitutional Delay of Puberty Adolescents with constitutional delay of puberty present with the late onset of sexual, adrenal, and skeletal maturation. Adolescents who begin to mature on time but then stall in their development do not have constitutional delay. Thus, the presence of secondary sex characteristics excludes the diagnosis of constitutional delay and should

Delayed Puberty

prompt a search for other causes of hypogonadotropic hypogonadism. Constitutional delay of puberty always involves a decline in growth velocity relative to peers of the same age and sex. Adolescents with constitutional delay grow at the childhood rate of 5–7 cm per year, whereas their peers grow at the pubertal rate of 8–14 cm per year. However, because bone age in constitutional delay correlates better with height age (i.e., the chronological age at which the height would be average) than with the current chronological age, most adolescents with constitutional delay ultimately achieve a normal adult height. Adolescents with constitutional delay who have severely decreased pre-pubertal growth velocity (i.e., below 5 cm per year) or very late sexual maturation may not achieve the expected adult height. Growth of the long bones exceeds growth of the vertebral column in these patients, resulting in eunuchoidal proportions (i.e., arm span exceeds height by more than 5 cm) and lower-than-predicted adult height. The psychosocial impact of constitutional delay appears greater in boys than girls. In boys it has been associated with lower self-esteem, depression, reduced peer contact, and attention-deficit hyperactivity disorder. These psychosocial correlates may explain why boys are more likely than girls to seek and receive treatment for constitutional delay of puberty.

Other Causes of Functional Hypogonadotropic Hypogonadism (FHH) Chronic illness, impaired nutrition or weight gain, weight loss, excessive exercise, chronic use of corticosteroids, medication-induced hyperprolactinemia, and hypothyroidism are common causes of FHH. Unlike constitutional delay, which always presents as the late onset of puberty, these causes may delay the onset and/or slow the rate of pubertal development. For example, illness beginning after the appearance of early secondary sexual characteristics may stall puberty at the given Tanner stage, cause primary amenorrhea in the pre-menarcheal female, or cause secondary amenorrhea in the post-menarcheal female. Any chronic systemic illness can interfere with growth and development. Up to a third of adolescents with newonset Crohn’s disease present with growth failure rather than gastrointestinal symptoms. The deficit in weight tends to be greater than the deficit in height, and delay or stall in pubertal development is common. Celiac disease usually presents before adolescence and is a treatable cause of short childhood stature and pubertal delay. Cystic fibrosis affects growth and puberty through decreased energy intake; increased energy requirements associated with the work of breathing; malabsorption; and chronic or recurrent infection. Hypothyroidism frequently presents as growth failure and, unlike gastrointestinal diseases, the deficit in height exceeds that in weight.

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Structural Hypogonadotropic Hypogonadism The major diagnoses in this category include hypothalamic and pituitary tumors, irradiation of the central nervous system (CNS), and congenital GnRH deficiency. Craniopharyngioma, the most common CNS tumor associated with delayed puberty, typically presents at 6 to 14 years of age with headache, short stature, polydipsia, and polyuria. Less common tumors include germinomas, prolactinomas, and chromophobe adenomas. The most common cause of idiopathic hypogonadotropic hypogonadism is congenital GnRH deficiency, or the absence of GnRH secretion by the hypothalamus. The inheritance pattern may be autosomal dominant, autosomal recessive, X-linked, or sporadic. The age of diagnosis and clinical presentation vary widely, from infancy (e.g., cryptorchidism) to childhood (e.g., anosmia), to adolescence (e.g., delayed puberty), to adulthood (e.g., normal puberty with subsequent infertility). Anomalies associated with congenital GnRH deficiency include cleft lip or palate, unilateral renal agenesis, unilateral or bilateral cryptorchidism, and hyposmia or anosmia (i.e., Kallman syndrome). The absence of GnRH secretion cannot be established by serum assay but is supported by the absence of endogenous LH surges and the increase in serum LH induced by exogenous GnRH. Other inherited causes of hypogonadotropic hypogonadism include Prader-Willi, Laurence-Moon, and BardetBiedl syndromes. Prader-Willi syndrome is an autosomal dominant condition manifested as infantile hypotonia, childhood hyperphagia and obesity, characteristic facies, small hands and feet, adolescent short stature, and delayed puberty. Micropenis is common in boys, and early adrenarche is common in boys and girls. Laurence-Moon and Bardet-Biedl syndromes are both rare, autosomal recessive conditions with hypogonadism and retinitis pigmentosa. Laurence-Moon syndrome is associated with spastic paraplegia. Bardet-Biedl syndrome is associated with polydactyly, childhood obesity, and renal dysplasia.

Hypergonadotropic Hypogonadism Primary gonadal failure leads to hypergonadotropic hypogonadism. The two most common forms are Klinefelter syndrome and Turner syndrome, both of which are associated with abnormalities in the sex chromosomes. Klinefelter syndrome, or seminiferous tubular dysgenesis, occurs in approximately 1 per 1000 male births. The clinical findings include small, firm testes; gynecomastia; eunuchoidal proportions; aortic valvular disease; osteoporosis; breast cancer at 20 times the baseline male rate; germ cell tumors; leukemia; and lymphoma. Most men with Klinefelter syndrome have a 47,XXY karyotype.

62 Adolescent Medicine: The Requisites in Pediatrics

Although full-scale IQ is often in the normal range, the verbal IQ is typically 10–20 points lower than the mean. Turner syndrome, or gonadal dysgenesis, occurs in 1 per 2500 female births. Sixty percent of cases have a 45,X karyotype with the classic presentation of female phenotype, short stature, and hypogonadism. Common findings include micrognathia; high-arched palate; ptosis; short, webbed neck (pterygium colli); impaired hearing (from recurrent otitis media); broad, shield-like chest; short fourth metacarpals; cubitus valgus; and genu valgum. Aortic valvular disease includes bicuspid valves, stenosis, and coarctation, and there are abnormalities in renal position, vascularization, and drainage. Autoimmune disorders are common in Turner syndrome, including thyroid disease and inflammatory bowel disease. Full-scale IQ is usually normal, but performance IQ is typically 10–20 points lower than the mean and reading scores are often higher than suggested by the full-scale IQ. Forty percent of patients with Turner syndrome have genetic mosaicism. Those with 45,X/46,XX (the most common mosaic pattern) and 45,X/47,XXX are phenotypically female, chromatin-positive on buccal smear, and have milder clinical manifestations than do those with the classic 45,X karyotype. Those with the less common pattern of 45,X/46,XY may be phenotypically female or male and may vary in the frequency and severity of the other findings of classic Turner syndrome. Other causes of hypergonadotropic hypogonadism include gonadal failure from chemotherapy or radiation, autoimmune gonadal disorders, biosynthetic defects, or resistance to LH (males) or FSH (females).

Evaluation The first step in the evaluation of delayed puberty is to determine by history and physical examination the age of onset and the progression of secondary sexual characteristics. Patients with constitutional delay of puberty have late onset without stalled progression, whereas those with other causes may have any combination of late onset and stalled progression. Although serum gonadotropin levels differentiate primary from secondary hypogonadism, no single test differentiates the most frequent causes of delayed puberty (i.e., constitutional delay and other causes of FHH). The history with review of the growth record and the physical examination are therefore important guides to the laboratory evaluation (Box 10-2). Past medical history should include detailed questioning about congenital anomalies, eating and nutrition, chronic or recurrent illness during childhood, endocrine disorders, trauma or surgery, and medications. If systemic illness is suspected, the review of systems should seek to identify symptoms associated with the diagnoses of concern. Family history should be reviewed for late puberty

Box 10-2  Laboratory and Radiographic

Evaluation of Delayed Puberty

Baseline   Serum estradiol and testosterone   Serum FSH and LH   Serum thyroxine, TSH   Serum prolactin   Bone age Follow-up   CBC, serum chemistry panel, urinalysis, ESR, CRP   Olfactory testing   Chromosomal analysis   Head MRI or CT   Pelvic ultrasound in females   GnRH or GH stimulation testing

or menarche in parents and siblings and heights of parents, siblings, and grandparents. If a specific inherited syndrome is suspected, parents should be questioned about manifestations of that syndrome within the extended family (i.e., anosmia in Kallman syndrome). The physical examination should include particular attention to sexual maturity (i.e., Tanner) ratings; the ­measurement of height, weight, arm span, upper body length (top of head to symphisis pubis), and lower body length (symphisis pubis to floor); calculation of body mass index (BMI); arm span/height ratio; and upper/lower (U/L) body ratio. The U/L ratio declines during childhood, reaching 0.9–1.0 by adulthood. Hypothyroidism is associated with a high ratio (> 1.0), whereas hypogonadism is associated with a low or normal ratio. Other important findings on the physical examination include visual field cuts or papilledema; goiter; evidence of chronic lung disease; signs of congenital heart disease; hepatosplenomegaly or abdominal mass; fissures, fistulae, skin tags, or hemorrhoids on rectal examination; and neurological examination. If Kallman syndrome is suspected, patients should be referred for genetic and endocrine consultation as well as formal olfactory evaluation because office testing is unreliable. Initial laboratory studies should include measurement of serum estradiol (females), testosterone (males), FSH, LH, thyroxine, thyroid-stimulating hormone (TSH), and bone age. Subsequent studies are determined by these results, along with the history and physical examination. Complete blood count, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and serum chemistry profile usually are performed if chronic illness is suspected. Imaging studies of the head, such as magnetic resonance imaging (MRI) or computed tomography (CT), are indicated in the setting of neurological signs or symptoms suggesting a CNS tumor and in patients with anosmia or hyposmia on formal olfactory testing. Pelvic ultrasound is indicated to confirm the

Delayed Puberty

presence of ovaries and Mullerian structures (i.e., uterus and tubes). Chromosomal analysis should be performed if Klinefelter syndrome, Turner syndrome, Kallman syndrome, or other genetic condition is suspected. The diagnosis of growth hormone (GH) deficiency and assessment of pituitary function can be particularly difficult in adolescents with delayed puberty. Insulin-like growth factor 1 (IGF-1) and IGF-binding protein 3 (IGF-BP3) are secreted in response to growth hormone (GH) and mediate the effect of GH on skeletal growth. However, factors other than GH affect IGF-1 and IGF-BP-3 levels, such as malnutrition and low body weight. High levels usually exclude GH deficiency, but low or normal levels do not confirm it. If GH deficiency remains in the differential diagnosis, the patient should be referred to an endocrinologist for stimulation testing. In adolescents with severe hypogonadotropic hypogonadism, the GnRH stimulation test can help determine whether anterior pituitary function is appropriate for the level of pubertal development. The test is done best by an endocrinologist in a controlled setting.

Management Watchful waiting is the initial management of most adolescents with delay in the onset of puberty. If the likely diagnosis is constitutional delay and the adolescent is coping well, visits can occur at 3- to 6-month intervals until puberty begins, psychosocial problems arise, or the diagnosis of constitutional delay is in question. Hormonal treatment of constitutional delay usually is prompted by adolescent discomfort with short stature or physical immaturity and is more commonly requested by males than females. The short-term (i.e., 6-month) use of low-dose testosterone in males or estrogen in females, as outlined in Box 10-3, will induce secondary sexual characteristics and an increase in height velocity with minimal to no effect on adult height. Most adolescents with constitutional delay will develop some secondary sexual characteristics during the 6-month treatment period and will continue to progress through puberty during the 6 months following discontinuation of the exogenous hormone. Although some patients may require a second course of treatment, failure to enter and progress with puberty increases the likelihood of a diagnosis other than constitutional delay and warrants further evaluation. Hypogonadism that persists in males or females beyond age 18 years without obvious cause suggests congenital GnRH deficiency. It is important to note that patients with constitutional delay and other causes of isolated GnRH deficiency are not deficient in GH, despite low levels of serum IGF-1. Although there is some controversy about the use of exogenous GH in constitutional delay, the weight of the evidence does not support its use. In contrast, GH therapy is indicated for the treatment of short stature associated

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Box 10-3  6-Month Hormonal Therapy

for Constitutional Delay of Puberty

Males Females

Testosterone enanthate 50 mg intramuscularly every 4 weeks Ethinyl estradiol 5–10 μg or conjugate

with Turner syndrome before beginning estrogen therapy. All patients with Turner syndrome should therefore be referred to an endocrinologist for consultation regarding the timing, type, and dosage of hormonal therapy. Pubertal delay secondary to an underlying illness requires treatment of the illness. In some cases, specific interventions will trigger puberty even if the illness persists. Examples include hyperalimentation in inflammatory bowel disease and enzyme replacement in cystic fibrosis. In others, an intervention may be curative, as in corrective surgery for congenital heart disease. If puberty remains markedly delayed despite aggressive treatment of the underlying disease, referral to an endocrinologist is warranted. Patients with permanent hypogonadism require ongoing hormone replacement therapy with counseling about reproductive potential and long-term follow-up for medical monitoring and support.



Major Points

b

Constitutional delay accounts for more than 50% of cases of delayed puberty, with a 2:1 ratio of males to females. Other causes of decreased secretion of GnRH account for 35%. l Constitutional delay presents with late onset of sexual, adrenal, and skeletal maturation. Adolescents who enter puberty on time but then stall in their development do not have constitutional delay. l Other causes of hypogonadotropic hypogonadism may delay the onset and/or slow the rate of pubertal development. Chronic illness, malnutrition, hypothyroidism, CNS tumors, and congenital GnRH deficiency are included in this category. l Turner syndrome in females and Klinefelter syndrome in males are the leading causes of primary gonadal failure, or hypergonadotropic hypogonadism. Other causes include chemotherapy, radiation, autoimmune gonadal disorders, and biosynthetic defects. l Evaluation of delayed puberty begins with review of the growth history, determination of the sexual maturity ratings (i.e.,Tanner stages), measurement of the serum FSH and LH levels, and bone age. Additional evaluation is guided by these findings as well as the detailed history and physical examination. l

64 Adolescent Medicine: The Requisites in Pediatrics

Bibliography Danielson KK, Palta M, Allen C, et al.: The association of increased total glycosylated hemoglobin levels with delayed age at menarche in young women with type 1 diabetes. J Clin Endocrinol Metab 2005; 90:6466–6471. Graber JA, Seeley JR, Brooks-Gunn J, et al.: Is pubertal timing associated with psychopathology in young adulthood? J Am Acad Child Adolesc Psychiatry 2004; 43:718–726. Grimberg A, Kutikof JK, Cucchiara AJ: Sex differences in patients referred for evaluation of poor growth. J Pediatr 2005;146:212–216. Grumbach MM, Styne DM. Puberty: Ontogeny, neuroendo­ crinology, physiology, and disorders. In Larsen PR, Kronenberg HM, Melmed S, Polonsky KS, Williams Textbook of Endo­ crinology, 10th ed. Philadelphia: Saunders (Elsevier), 2003. Gubitosi-Klug RA, Cuttler L: Idiopathic short stature. Endocrinol Metab Clin North Am 2005;34:565–580. Herman-Giddens ME, Kaplowitz PB, Wasserman R. Navigating the recent articles on girls’ puberty in Pediatrics: What do we know and where do we go from here?. Pediatrics 2004;113: 911–917. Herman-Giddens ME, Wang L, Koch G: Secondary sexual characteristics in boys. Estimates from the National Health and Nutrition Examination Survey III, 1988–1994. Arch Pediatr Adolesc Med 2001;155:1022–1028. Johansson T, Ritzen EM: Very long-term follow-up of girls with early and late menarche. Endocr Dev 2005;8:126–136. Kaplowitz PB, Oberfield SE: Reexamination of the age limit for defining when puberty is precocious in girls in the United

States: Implications for evaluation and treatment. Pediatrics 1999;104(4 Pt 1):936–941. Pitteloud N, Hayes FJ, Boepple PA, et al.: The role of prior pubertal development, biochemical markers of testicular maturation, and genetics in elucidating the phenotypic hetero­ geneity of idiopathic hypogonadotropic hypogonadism. J Clin Endocrinol Metab 2002;87:152–160. Pozo J, Argente J: Ascertainment and treatment of delayed puberty. Horm Res 2003;60(Supp 3):35–48. Quigley CA, Gill AM, Crowe BJ, et al.: Safety of growth hormone treatment in pediatric patients with idiopathic short stature. J Clin Endocrinol Metab 2005;90:5188–5196. Raivio T, Dunkel L,Wickman S, et al.: Serum androgen bioactivity in adolescence: A longitudinal study of boys with constitutional delay of puberty. J Clin Endocrinol Metab 2004;89:1188–1192. Sedlmeyer IL, Palmert MR: Delayed puberty: Analysis of a large case series from an academic center. J Clin Endocrinol Metab 2002;87:1613–1620. Selevan SG, Rice DC, Hogan KA, et al.: Blood lead concentration and delayed puberty in girls. N Engl J Med 2003;348:1527–1536. Seminara SB, Messager S, Chatzidaki EE, et al.: The GPR54 gene as a regulator of puberty. N Engl J Med 2003;349:1614–1627. Sun SS, Schubert CM, Chumlea WC, et al.: National estimates of the timing of sexual maturation and racial differences among U.S. children. Pediatrics 2002;110:911–919. Wright CM, Cheetham TD: The strengths and limitations of parental heights as a predictor of attained height. Arch Dis Child 1999;81:257–260.

ChApter

11

Introduction Definitions Epidemiology and Natural History Complications of Obesity Evaluation of Overweight Adolescents Management Behavior Modification Pharmacotherapy Bariatric Surgery

Introduction Since the mid 1980s, obesity has increased to epidemic proportions in pediatric age groups. In parallel with this trend are increases in obesity-related morbidity during childhood and premature mortality during adulthood. New treatment options do exist, such as surgery for adolescents whose severe obesity otherwise would result in certain illness and early death. However, for most obese children and adolescents, effective prevention and treatment strategies remain elusive. This chapter reviews the definitions, epidemiology, natural history, pathophysiology, evaluation, and management of obesity that begins in, or continues into, adolescence.

Definitions Body mass index (BMI), defined as weight in kilograms (kg) divided by the square of height in meters (m2), provides a simple, reproducible screening tool for adiposity in children and adults. BMI cut-points for levels of adiposity have been proposed by the Centers for Disease Control and Prevention (CDC) for all age groups in the United States (Table 11-1). For an adult, a BMI below 18.5

Obesity Thomas H. INGE, MD, PhD, FACS, FAAP Stephen R. Daniels, MD, PhD

is considered underweight, 18.5–24.9 is considered a healthy weight, 25.0–29.9 is considered overweight, and 30 or higher is considered obese. For a child or adolescent, the CDC uses BMI percentile for age and gender, rather than BMI, and uses the labels “at risk of overweight” and “overweight” rather than “overweight” and “obese.” The label “at risk of overweight” is defined as the 85th to 94.9th percentiles. The label “overweight” is defined as the 95th percentile or higher. In adults, the term “morbid obesity” refers to BMI levels of 40 kg/m2 or greater. In children and adolescents, there has been little research upon which to base a definition of morbid obesity. However, BMI levels of 35–40 kg/m2 correspond to at least the 99th percentile for older adolescents and may represent a clinically useful cut-point for defining morbid obesity in children and adolescents.

Epidemiology and Natural History Between 1986 and 2000, the proportions of U.S. adults with obesity, morbid obesity, and BMI levels at or above 50 kg/m2 increased two-, four-, and five-fold, respectively. Obesity among children and adolescents in the United States increased three-fold in 25 years, and the increases are two times higher in black and Hispanic than white youth. Of the 16% of children and adolescents who now meet CDC criteria for overweight, significantly more are in the highest weight percentiles compared with two to three decades earlier. The increased prevalence and ­severity of childhood obesity has led to increased health care costs that are both related to obesity and incurred before adulthood. A recent study estimated a three-fold increase over 20 years in the cost of pediatric hospitalizations for conditions directly related to obesity. Even more costly are the effects of childhood weight status on adult obesity and its associated morbidity and 65

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Adolescent Medicine: The Requisites in Pediatrics

Table 11-1  CDC Weight Categories for Adults as Compared with Children and Adolescents1 Adults

Children and Adolescents

Category

BMI (kg/m )

Category

BMI Percentile

Underweight Normal Overweight Obese

Below 18.5 18.5–24.9 25.0–29.9 30 or higher

Underweight Normal At risk of overweight Overweight

Below 5th 5th to 84.9th 85th to 94.9th 95th or higher

2

1 For adults, the labels refer to ranges of BMI, calculated as weight divided by height squared. For children and adolescents, the labels refer to ranges of BMI percentiles, adjusted for age and gender.

mortality. A 30-year prospective study demonstrated a mortality rate that was twice as high in adolescents who were obese at enrollment compared with those who were lean. In another study, the lifespan of young adults aged 20–30 years with BMI levels above 45 kg/m2 was significantly shorter than that of leaner subjects. The mean number of years lost was 20 for black males, 5 for black females, 13 for white males, and 8 for white females.

Complications of Obesity Until recently, the adipocyte, or fat cell, was considered a passive site for the storage of excess energy in the form of triglycerides. The identification of leptin, however, generated a new model of energy balance in which the adipocyte plays a more active role. Adipocytes collectively represent a secretory endocrine organ producing leptin and inflammatory cytokines (e.g., TNF, IL-6, adiponectin) that may help explain the association of obesity with disorders of many organ systems (Figure 11-1). Some of these conditions are discussed next. Coronary heart disease (CHD). Obesity is strongly associated with adult CHD and with the development of other risk factors for CHD. During childhood, obesity carries nearly a 10-fold risk for hypertension and is associated with low HDL-cholesterol and high triglyceride levels. Nearly 30% of obese adolescents, or up to 910,000 adolescents in the United States, have a cluster of risk factors for CHD known as the metabolic syndrome (i.e., abdominal obesity, insulin resistance, hypertension, and hyperlipidemia). Type 2 diabetes mellitus (DM). The diagnosis of Type 2 DM during adolescence increased 10-fold during the 1980s and 1990s. The epidemic of Type 2 DM has paralleled that of obesity, and the CDC projects that up one-third of all children and one-half of black and Hispanic children, born in the United States today will develop Type 2 DM during their lifetimes. The pathophysiology

of Type 2 DM in children and adolescents probably begins with ß-cell dysfunction in the setting of insulin resistance. The physical finding of acanthosis nigricans, or darkly-pigmented, thickened skin of the neck or axillae, is associated with hyperinsulinemia and insulin resistance. The diagnosis of Type 2 DM depends on two separate fasting blood glucose levels above 125 mg/dl or a single level above 125 mg/dl in the presence of symptoms such as polydipsia and polyuria. Oral glucose tolerance testing is usually performed to establish the diagnosis. Although the cornerstones of clinical management are diet and physical activity, the low and delayed response rates have resulted in increasing use of metformin (see Chapter 13). Sleep-disordered breathing. Childhood obesity is associated with a spectrum of breathing disorders during sleep involving episodes of upper airway obstruction that vary in frequency and severity. The most severe form is the obstructive sleep apnea (OSA) syndrome, in which breathing ceases for 10 or more seconds. The presenting signs and symptoms of sleep-disordered breathing include nocturnal snoring, restlessness, and frequent awakening; oxygen desaturation and hypercapnia during sleep; and daytime somnolence. In adults, OSA is associated with sympathetic overstimulation and cardiovascular hyperresponsiveness. In children, it is associated with paradoxical hyperactivity, impaired neurocognitive function, and enuresis. The long-term consequences of OSA include sustained daytime hypertension and increased cardio­ vascular mortality. The evaluation and management of sleep disorders in adolescents are discussed in detail in Chapter 17. Non-alcoholic fatty liver disease (NAFLD). Children with early-onset obesity and insulin resistance are at high risk for a spectrum of liver disorders known collectively as NAFLD. The spectrum ranges from fatty infiltration of the liver alone (steatosis) to fatty infiltration with hepatocellular inflammation (steatohepatitis) to hepatocellular necrosis, fibrosis, and cirrhosis. The most



Obesity

67

COMPLICATIONS OF CHILDHOOD OBESITY Psychosocial Poor self-esteem Depression Quality of life Pulmonary Asthma Sleep apnea Exercise intolerance Renal Glomerulosclerosis Proteinuria Gastrointestinal Paniculitis Steatohepatitis Liver fibrosis Gallstones Risk for cirrhosis Risk for colon cancer Musculoskeletal Forearm fracture Blount’s disease Slipped capital femoral epiphysis Flat feet Risk for degenerative joint disease

Neurological Pseudotumor cerebri Risk for stroke Cardiovascular Dyslipidemia Hypertension Left ventricular hypertrophy Chronic inflammation Endothelial dysfunction Risk of coronary disease Endocrine Type 2 diabetes Precocious puberty Polycystic ovary syndrome (girls) Hypogonadism (boys) Hernia DVT/PE Stress incontinence Risk of GYN malignancy

Figure 11-1     Adapted from: Xanthakos SA, Daniels SR, Inge TH: Bariatric surgery in adolescents: An update. Adolesc Med Clinics 2006;17:589–612.

advanced forms of the spectrum occur in adults with morbid obesity and Type 2 DM. Elevation of the serum transaminases can be used to screen obese children and adolescents for NAFLD, but liver biopsy is required for diagnosis and staging. The prevalence of NAFLD in obese children and adolescents who progress to liver biopsy ranges from 50–80%, with steatohepatitis in two-thirds and fibrosis in one-third. Preliminary studies demonstrate regression of steatohepatitis and fibrosis in adolescents and adults with significant weight loss following bariatric surgery. Pseudotumor cerebri. Idiopathic elevation of the intracranial pressure, or pseudotumor cerebri, occurs in less than 1 per 100,000 children and adults. Risk factors for its development include adolescent age and obesity (30– 50% of patients). There is no gender predominance in children and adolescents with pseudotumor cerebri, but adult women aged 20–44 years who are at least 20% above ideal body weight appear to be at increased risk. Presenting symptoms include headache that is often pulsatile and nocturnal; nausea and vomiting; neck pain; eye pain with extraocular movement, diplopia, and other visual change; vertigo; and tinnitus. Common findings on physical examination include papilledema (50–100% of adolescent patients); sixth nerve palsy (less than 50% of adolescent patients); visual field cuts; and nystagmus. Pseudotumor cerebri is a

diagnosis of exclusion that depends on increased pressure on lumbar puncture (above 200 mm H2O); otherwise normal cerebrospinal fluid (CSF); the absence of ventricular obstruction, deformity, or displacement on neuroimaging; and no other identifiable cause of increased intracranial pressure (ICP). An empty sella on computed tomography (CT) or magnetic ­resonance imaging (MRI) of the head is found in up to 70% of patients and does not exclude the diagnosis. Ophthalmology and neurology consultations are indicated for children and adolescents with pseudotumor cerebri because of the high risk of vision loss. The acute management typically includes serial lumbar punctures to lower ICP and acetazolamide to decrease CSF production. Corticosteroids, optic nerve fenestration, and lumboperitoneal shunting are reserved for patients with severe visual impairment. Ongoing therapy for obese children and adolescents centers on weight loss given the evidence that even modest reductions are associated with more rapid resolution of papilledema and visual dysfunction. Psychosocial development. The most common complications of obesity during late childhood and adolescence may well be psychosocial. Although social stigmas associated with obesity transcend age, the negative effects can be particularly damaging to evolving self-concept, family and peer relationships, and the formation of social networks. Obese adolescents have lower self-esteem, fewer friends,

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Adolescent Medicine: The Requisites in Pediatrics

higher rates of school drop-out, and lower rates of job success than do non-obese peers. The social adversity that begins in adolescence continues into adulthood, with increased rates of psychopathology and lower levels of economic achievement. Quality of life and socioeconomic status have been shown to improve for morbidly obese adults following significant weight loss, but it remains unknown whether similar effects will be realized by children and adolescents.

Evaluation of Overweight Adolescents There is considerable controversy among health professional organizations regarding recommendations for overweight screening and evaluation in children and adolescents. All organizations agree that the problem is significant and that there is a paucity of research on the effectiveness of screening. The differences stem from how the organizations choose to apply the limited evidence that is available. In 2005, the U.S. Preventive Services Task Force (USPSTF) updated its 1996 screening recommendations for overweight children and adolescents. Although the report acknowledges the increasing prevalence of childhood obesity and the accompanying risks to health and quality of life, it concluded that the available evidence does not support screening as a means of improving outcome. In contrast, the American Academy of Pediatrics and the Maternal and Child Health Bureau do recommend screening for family factors and health conditions associated with overweight. In 2004, the Institute of Medicine (IOM) published recommendations for overweight screening and intervention during childhood and adolescence that were based on the best “available” evidence. The IOM acknowledged the limitations of this evidence but argued that waiting for the “best possible evidence” was not an option given the increasing rates of obesity in the United States. The recommendations that follow adhere to the approach suggested by the IOM and represent a composite from general guidelines for preventive care and specific approaches to the identification of conditions associated with adolescent obesity. Guidelines for Adolescent Preventive Services (GAPS) and Bright Futures: Guidelines for Health Supervision of Adolescents (see Chapter 2) recommend annual determination of BMI and examination of the trend in BMI percentile over time. The 2004 IOM report, Preventing Childhood Obesity: Health in the Balance calls for routine tracking of the BMI in children and adolescents, with appropriate counseling about weight management. These recommendations for regular assessment of the BMI hold for all adolescents, regardless of weight category, and are particularly important for adolescents who meet CDC criteria for overweight.

Once the diagnosis of overweight is established, the adolescent and parent should be asked about family history of obesity, diabetes mellitus, hypertension, hyperlipidemia, and CHD. Patient and family eating behavior, caloric intake, physical activity, and efforts to lose weight should be discussed. Review of systems should include questions about symptoms associated with comorbid conditions such as insulin resistance, DM, and sleep-disordered breathing. It also should explore symptoms suggestive of disorders that may cause excessive weight gain, such as hypothyroidism. The physical examination of overweight and obese adolescents continues along the same line as the history, with particular attention to signs suggesting comorbid or causative conditions, such as elevated blood pressure, dysmorphic features, acanthosis nigricans, thyromegaly, or hepatomegaly. The cost-effectiveness of routine laboratory testing in the evaluation of obese adolescents has not been studied, but measurement of fasting glucose and insulin levels, serum lipids, and liver function tests should be considered.

Management Behavior Modification Studies on the effectiveness of treatment strategies for overweight children and adolescents remain limited in number and variable in their findings. Although several have demonstrated significant and sustained weight loss with family-based behavioral therapy, many others reveal no weight loss and only modest, short-term effects on self-esteem. Even those studies demonstrating weight reduction suffer from selection and retention biases favoring motivated subjects and families. For example, in a recent study of obese children and adolescents participating in a family-centered behavioral program, half the subjects withdrew from the program before completing the initial 6 months. Although the drop-out rate was discouragingly high, the results for the 177 subjects who completed the program were promising. Mean reductions in weight and BMI at 6 months were 2.0 kg and 1.7 kg/m2, respectively. Significant improvements were also found in blood pressure; serum levels of total cholesterol, low-density-lipoprotein cholesterol (LDL-C) triglycerides, and insulin; and aerobic fitness.

Pharmacotherapy Reports in the 1990s of late adverse side effects in adult patients who had used pharmacotherapy for weight reduction slowed both the development of new pharmacological agents for the management of obesity and the testing



Obesity

of these agents in children and adolescents. The recent U.S. Food and Drug Administration (FDA) approval of sibutramine and orlistat for use in the management of pediatric obesity therefore represents an important advance. Sibutramine is a nonselective reuptake inhibitor of serotonin and norepinephrine that is approved for use in patients aged 16 years and older. Clinical trials of sibutramine plus behavioral modification in adolescents resulted in 8–10% reductions in BMI; reductions in serum levels of total cholesterol, LDL cholesterol, triglycerides, glucose, and insulin; and increases in HDL cholesterol (HDL-C). Important side effects of sibutramine, which may limit its use, are increases in blood pressure and heart rate. Orlistat inhibits intestinal lipase activity and partially reduces intestinal absorption of triglyceride and cholesterol. Pediatric studies of orlistat have yielded mean reductions in BMI of 0.55 to 6.0 kg/m2, side effects in 50–100% of subjects, and attrition rates as high as 33%. The typical side effects reflect fat malabsorption (e.g., oily stools, flatus with discharge, diarrhea, fecal incontinence, and abdominal cramps) and improve with restriction of dietary fat.

Bariatric Surgery Gastrointestinal surgery has been considered a reasonable option for adults with morbid obesity since its 1991 review by a National Institutes of Health Consensus Development Conference. Outcome studies in adults have demonstrated postoperative weight reductions of 25–35% and reversal of major comorbidities such as Type 2 DM, OSA, dyslipidemia, and hypertension. The roux en Y gastric bypass procedure (GBP) is the gold standard procedure in adults, having been used for more than four decades. It is the only procedure in which safety and efficacy have been studied in adolescents. Refinements in technique have resulted in a minimally invasive (i.e., laparoscopic) approach in which a 30-ml gastric pouch is created just beyond the gastroesophageal junction. A 75- to 150-cm roux limb of jejunum is attached to the gastric pouch using a 1.0- to 1.5-cm anastomosis, which impairs rapid emptying of the pouch. Digestive secretions from the remnant stomach and duodenum merge with the roux limb downstream to allow emulsification and enzymatic degradation of macronutrients. Most patients consume 500–700 kilocalories (kcals) daily for 3 months postoperatively, increasing to 1000–1500 kcals daily by 1 year. Mortality associated with GBP in adults is 0.5–1.0%, and morbidity includes gastrointestinal leakage, pulmonary embolism, bowel obstruction, bleeding, and micronutrient deficiencies. Long-term follow-up has revealed late weight gain in up to 15% of patients. A second bariatric procedure, adjustable gastric banding (AGB), was approved by the FDA in 2001 for use in

69

adults. It involves the laparoscopic placement of a prosthetic band around the proximal stomach, resulting in a small gastric pouch above the band and considerable restriction of food intake. The inner diameter of the band can be adjusted by instilling saline into a subcutaneous port. Advantages of AGB over GBP are its lower mortality rate of 0.05% and its reversibility. However, AGB carries additional risks, such as gastric erosion at the band site, gastric obstruction caused by band displacement, and complications at the subcutaneous port site. Bariatric surgery is now considered a therapeutic option for adolescents with morbid obesity who have documentation of concerted efforts to lose weight, comorbid conditions, and family agreement about the procedure. For adolescents with BMI levels of 40–50 kg/m2, surgery usually is not performed unless there is a severe comorbid condition such as Type 2 DM, OSA, or pseudotumor cerebri. For adolescents with BMI levels > 50 kg/m2, surgery should be considered even if the comorbid conditions are less severe. Examples include hyper­tension, dyslipidemia, metabolic syndrome, polycystic ovary syndrome, stress urinary incontinence, ­signi­ficant impairment in activities of daily living, steatohepatitis, arthropathies in weight-bearing joints, gastroesophageal reflux disease, and significant psychosocial distress. An adolescent who is a candidate for bariatric surgery should be referred to a specialized center with a multidisciplinary bariatric team that is capable of evaluating and managing the medical and psychological problems that commonly arise in the perioperative period. In addition, the team should provide the long-term follow-up required for both management and research purposes. The core team includes experts in surgery, pediatrics and/or int­ernal medicine, psychology, nutrition, and exercise phy­siology. Consultants should be available in adolescent medicine, endocrinology, pulmonology, gastroenterology, cardiology, orthopedics, and ethics. Finally, institutional capabilities to manage morbidly obese patients must be considered, such as adequate hospital beds and radiology equipment. A review of 65 adolescents with preoperative BMI ranging from 43–96 kg/m2 who underwent laparoscopic GPB lost an average 2.5 kg per week over the first 6 months, after which the rate decreased. Mean weight loss was 25% at 6 months and 35% at 1 year. Body fat fell from 47% preoperatively to 36% at 1 year. Although some patients continued to lose weight up to 18 months after surgery, in most the BMI stabilized by 1 year. Baseline and 1-year laboratory results demonstrated significant decreases in serum triglycerides, total cholesterol, glucose, and fasting insulin (Table 11-2). Preoperative polysomnographic data revealed that 19 of 34 (55%) patients had OSA by strict diagnostic criteria. Postoperatively, after a mean weight loss of 58 kg, the mean index of severity decreased 10-fold, essentially eliminating the problem.

70

Adolescent Medicine: The Requisites in Pediatrics

Table 11-2 Mean Levels of Glucose, Insulin, Total Cholesterol, and Triglycerides for Adolescents with Morbid Obesity Before and 1 Year After Bariatric Surgery Baseline

p1

1 Year

N2

Level

N2

Level

Glucose (mg/dl)

22

104

24

  84

0.0010

Insulin (μU/ml)

20

  56

25

  10

0.0044

Total cholesterol

21

170

23

151

0.0001

Triglycerides (mg/dl)

21

155

22

  86

0.0003

Probability value was calculated using the two-tailed Student’s t-test for paired data. Number of patients for whom data was available at baseline and 1 year.

1 2



Major Points

b

The prevalence and severity of obesity among children and adolescents have increased dramatically in the last two decades. Prevention efforts have been ineffective thus far, and most obese children and adolescents are now developing medical and psychosocial comorbidities. l  CDC-defined weight categories differ for children and adolescents as compared with adults. The pediatric definitions are based on BMI percentile adjusted for age and gender, whereas the adult definitions are based on BMI. The pediatric categories are “at risk for overweight” and “overweight,” whereas the adult categories are “overweight” and “obese.” l  Severe complications of obesity seen during childhood and adolescence include Type 2 diabetes mellitus, obstructive sleep apnea, steatohepatitis, and pseudotumor cerebri. Other complications include insulin resistance, hypertension, dyslipidemia, and psychosocial problems. l The evaluation of overweight and obesity during childhood and adolescence has two goals: the identification of conditions that contribute to obesity (e.g., hypothyroidism, family history of obesity, sedentary lifestyle, high-caloric diet) and the identification of conditions exacerbated by obesity (e.g.,Type 2 diabetes mellitus, hypertension, steatohepatitis). l  Management begins with behavior modification of dietary intake and physical activity. Family involvement in the treatment program increases the likelihood of short- and long-term success. l  The FDA has approved the use of sibutramine and orlistat for the treatment of adolescent obesity. However, side effects have resulted in limited use and high rates of discontinuation. l  Since the early 1990s, bariatric surgery has been increasingly used for the management of morbid obesity in adults. Preliminary results from specialized centers indicate that surgery may provide an effective therapeutic option for adolescents with morbid obesity complicated by comorbid conditions.

l

Bibliography Apovian CM, Baker C, Ludwig DS, et al.: Best practice guidelines in pediatric/adolescent weight loss surgery. Obes Res 2005;13: 274–282. Barlow SE, Dietz WH: Obesity evaluation and treatment: Expert Committee recommendations. The Maternal and Child Health Bureau, Health Resources and Services Administration and the Department of Health and Human Services. Pediatrics 1998;102:E29. Brolin RE, Leung M: Survey of vitamin and mineral supple­ mentation after gastric bypass and biliopancreatic diversion for morbid obesity. Obes Surg 1999;9:150–154. Berkowitz RI, Wadden TA, Tershakovec AM, et al.: Behavior therapy and sibutramine for the treatment of adolescent obesity: A randomized controlled trial. JAMA 2003;289:1805–1812. Buchwald H, Avidor Y, Braunwald E, et al.: Bariatric surgery: A systematic review and meta-analysis. JAMA 2004;292:1724–1737. Chanoine JP, Hampl S, Jensen C, et al.: Effect of orlistat on weight and body composition in obese adolescents: A rando­ mized controlled trial. JAMA 2005;293:2873–2883. Chapman AE, Kiroff G, Game P, et al.: Laparoscopic adjustable gastric banding in the treatment of obesity: A systematic literature review. Surgery 2004;135:326–351. Dietz WH: Health consequences of obesity in youth: Childhood predictors of adult disease. Pediatrics 1998;101:518–525. Dietz WH, Robinson TN: Clinical practice. Overweight children and adolescents. N Engl J Med 2005;352:2100–2109. Dixon JB, Bhathal PS, Hughes NR, et al.: Nonalcoholic fatty liver disease: Improvement in liver histological analysis with weight loss. Hepatology 2004;39:1647–1654. Engeland A, Bjorge T, Sogaard AJ, et al.: Body mass index in adolescence in relation to total mortality: 32-year followup of 227,000 Norwegian boys and girls. Am J Epidemiol 2003;157:517–523. Falkner NH, Neumark-Sztainer D, Story M, et al.: Social, educational, and psychological correlates of weight status in adolescents. Obes Res 2001;9:32–42. Fontaine KR, Redden DT, Wang C, et al.: Years of life lost due to obesity. JAMA 2003;289:187–193.



Freedman DS, Khan LK, Dietz WH, et al.: Relationship of child­ hood obesity to coronary heart disease risk factors in adulthood: The Bogalusa Heart Study. Pediatrics 2001;108:712–718. Gastrointestinal surgery for severe obesity. Proceedings of a National Institutes of Health Consensus Development Conference. March 25–27, 1991, Bethesda, MD. Am J Clin Nutr 1992;55:487S–619S. Godoy-Matos A, Carraro L, Vieira A, et al.: Treatment of obese adolescents with sibutramine: A randomized, double-blind, controlled study. J Clin Endocrinol Metab 2005;90:1460–1465. Inge TH, Garcia VF, Daniels SR, et al.: A multidisciplinary app­ roach to the adolescent bariatric surgical patient. J Pediatr Surg 2004;39:442–447; discussion 446–447. Inge TH, Lawson ML, Garcia VF, et al.: Body composition changes after gastric bypass in morbidly obese adolescents. Obes Res 2004;12:A53. Inge TH, Krebs NF, Garcia VF, et al.: Bariatric surgery for severely overweight adolescents: Concerns and recommendations. Pedi­ atrics 2004;114:217–223.

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the Harvard Growth Study of 1922 to 1935. N Engl J Med 1992;327:1350–1355. Narayan KM, Boyle JP, Thompson TJ, et al.: Lifetime risk for diabetes mellitus in the United States. JAMA 2003;290:1884– 1890. Ogden CL, Flegal KM, Carroll MD, et al.: Prevalence and trends in overweight among US children and adolescents, 1999–2000. JAMA 2002;288:1728–1732. Schwimmer JB, Burwinkle TM, Varni JW: Health-related quality of life of severely obese children and adolescents. JAMA 2003;289:1813–1819. Sjostrom L, Lindroos AK, Peltonen M, et al.: Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 2004;351:2683–2693. Stefan N, Bunt JC, Salbe AD, et al.: Plasma adiponectin concentrations in children: Relationships with obesity and insulinemia. J Clin Endocrinol Metab 2002;87:4652–4656. Strauss RS, Pollack HA: Epidemic increase in childhood overweight, 1986–1998. JAMA 2001;286:2845–2848.

Inge TH, Zeller MH, Lawson ML, et al.: A critical appraisal of evidence supporting a bariatric surgical approach to weight management for adolescents. J Pediatr 2005;147:10–19.

Sugerman HJ, Sugerman EL, DeMaria EJ, et al.: Bariatric surgery for severely obese adolescents. J Gastrointest Surg 2003;7: 102–108.

Kalra M, Inge T, Garcia V, et al.: Obstructive sleep apnea in extremely overweight adolescents undergoing bariatric surgery. Obes Res 2005;13:1175–1179.

Troiano RP, Flegal KM: Overweight children and adolescents: Description, epidemiology, and demographics. Pediatrics 1998;101:497–504.

Kirk S, Zeller M, Claytor R, et al.: The relationship of health outcomes to improvement in BMI in children and adolescents. Obes Res 2005;13:876–882.

Williams CL, Hayman LL, Daniels SR, et al.: Cardiovascular health in childhood: A statement for health professionals from the Committee on Atherosclerosis, Hypertension, and Obesity in the Young (AHOY) of the Council on Cardiovascular Disease in the Young, American Heart Association. Circulation 2002;106:143–160.

Moran O, Phillip M. Leptin: Obesity, diabetes and other peri­ pheral effects—A review. Pediatr Diabetes 2003;4:101–109. Must A, Jacques PF, Dallal GE, et al.: Long-term morbidity and mortality of overweight adolescents. A follow-up of

12

C h A p t e r

Introduction Definitions Epidemiology Pathophysiology Evaluation BP Measurement History, Physical Examination, and Laboratory Studies

Management Nonpharmacological Therapy Pharmacotherapy

Introduction Cardiovascular disease (CVD) is the leading cause of death in the United States, and its prevalence is increasing dramatically in countries undergoing transition to a more Westernized lifestyle. The dietary and exercise patterns of this lifestyle begin in childhood and contribute heavily to the development of cardiovascular risk factors such as obesity and dyslipidemia. Obesity is associated with hypertension, and the obesity epidemic among U.S. children and adolescents is driving the upward trend in the rates of pediatric hypertension. This chapter reviews the definition, epidemiology, pathophysiology, evaluation, and management of adolescent hypertension. The recommendations discussed adhere closely to the Fourth Report on Children and Adolescents of the National High Blood Pressure Education Program Working Group (NHBPEP IV) and the Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure (JNC VII). 72

Hypertension ELAINE M. URBINA, MD STEPHEN R. DANIELS, MD, PHD

Definitions NHBPEP IV updates the 1987 definitions of hypertension (HTN) in children and adolescents. Unlike the adult definitions, which reflect the blood pressure (BP) levels at which treatment alters outcome, the pediatric definitions reflect the normative distribution of BP levels in the ­population. In normal children and adolescents, growth is associated with annual increases of 1.5  mmHg in the systolic BP and 0.7  mmHg in the diastolic BP (Figure 12-1). Rather than defining the range of normal by absolute BP, which increases with growth, NHBPEP IV definitions are based on the BP percentile, adjusted for age, gender, and height. Because an individual’s BP tends to track along a given percentile with growth, the percentile can help predict the likelihood of HTN during adulthood (Tables 12-1 and 12-2). For example, in the Bogalusa Heart Study, children with BP levels > 80th percentile were 3.6 times more likely than those with BP levels < 80th percentile to have diagnoses of HTN 15 years later. NHBPEP IV recommends the measurement of BP on three separate occasions before establishing a diagnosis of HTN. Normal is defined as BP readings < 90th percentile. Pre-HTN is defined as BP readings ≥ 90th percentile but < 95th percentile for age, gender, and height. For adolescents > 12 years and adults, this corresponds to BP readings ≥ 120/80 mmHg but < 95th percentile (Table 12-3). Stage 1 HTN is defined as BP readings ≥ 95th percentile but ≥ (99th percentile + 5 mmHg). Stage 2 HTN is BP readings > (99th percentile + 5 mmHg) and is intended to identify those patients who need prompt evaluation and treatment. The 5 mmHg addition widens the Stage 1 range from the 7-mm distance between the 95th and 99th percentiles to 12, thus allowing for more biological variability across measurements. It is important to note that the definitions of Stages 1 and 2 apply to chronic, not acute, HTN.  The slower development of chronic HTN



Hypertension MALES

FEMALES 130

140

BP (mmHg)

130

Figure 12-1 Blood pressure by age for children of average height.

73

SBP

120

SBP

120

110

110

100

100

90

90

80

DBP (K5)

80

70

70

60

DBP (K5)

50

60 3

5

7

9

11

13

15

17

3

5

7

9

11

13

15

17

Age (yrs) SBP 90% DBP 90%

results in arterial hypertrophy, which blunts the pressure effect on capillaries. Consequently, BP elevations that are considered moderate in chronic HTN may have severe consequences in acute HTN. White-coat HTN is defined as office BP readings ≥ 95th percentile in the context of normal readings outside the office. Studies utilizing ambulatory BP monitoring (see later) suggest that up to 25% of adults and 35% of children diagnosed with HTN have white-coat HTN. Although these patients may be at increased risk for the subsequent development of sustained HTN, their risk of adult CVD is low so long as readings outside the office remain normal.

Epidemiology The prevalence of HTN among school-aged children and adolescents in the United States has increased from appro­ ximately 1% in 1989 to 4.5% in 2002. In pre-pubertal children, 80–98% of HTN is secondary, or attributable to an identifiable cause. By mid-adolescence, however, at least 75% of new-onset HTN is essential, or without an identifiable cause. Essential HTN demonstrates strong, independent associations with obesity, sedentary lifestyle, high salt intake, family history of HTN, and race/ethnicity. Obesity increases the likelihood of HTN three-fold, hastens the development of left ventricular hypertrophy (LVH), and increases the risk of insulin resistance and hyperlipidemia.  The adolescent and adult rates of essential HTN are significantly higher among African-Americans than either whites or Mexican-Americans, and the adult

SBP 95% DBP 95%

rate of hypertensive end-organ disease is highest among African-Americans.

Pathophysiology HTN during childhood and adolescence is associated with the early development of atherosclerosis, LVH, and microvascular changes in the eye and kidney. Autopsy studies of adolescents who died of causes unrelated to CVD have revealed strong associations of antemortem BP with postmortem atherosclerosis, and noninvasive vascular studies in adolescents have demonstrated an association of BP with atherosclerotic indicators such as arterial stiffness, calcification, and intimal-medial thickness. Although 40% of adolescents with HTN demonstrate concentric LVH, which is an important predictor of CVD, adult studies demonstrate regression of LVH with BP control. Hypertensive microvascular damage to the kidney can begin in childhood but usually does not cause microalbuminuria until adulthood. When microalbuminuria does present in childhood, it is an ominous marker for the early progression of CVD. However, as with LVH, adult studies have demonstrated resolution of microalbuminuria with good BP control. The differential diagnosis of adolescent HTN is summarized in Table 12-4. Although essential HTN leads the list, it remains a diagnosis of exclusion. Factors that increase the likelihood of secondary HTN include prepubertal status, BP readings ≥ (99th percentile + 5 mmHg), negative family history of HTN, and thin body habitus. The most common causes of secondary HTN during Text continued on p. 76

BP Percentile

Systolic BP (mmHg) Height Percentile

Diastolic BP (mmHg) Height Percentile

5th

10th

25th

50th

75th

90th

95th

5th

10th

25th

50th

75th

90th

95th

11

50th 90th 95th 99th

  99 113 117 124

100 114 118 125

102 115 119 127

104 117 121 129

105 119 123 130

107 120 124 132

107 121 125 132

59 74 78 86

59 74 78 86

60 75 79 87

61 76 80 88

62 77 81 89

63 78 82 90

63 78 82 90

12

50th 90th 95th 99th

101 115 119 126

102 116 120 127

104 118 122 129

106 120 123 131

108 121 125 133

109 123 127 134

110 123 127 135

59 74 78 86

60 75 79 87

61 75 80 88

62 76 81 89

63 77 82 90

63 78 82 90

64 79 83 91

13

50th 90th 95th 99th

104 117 121 128

105 118 122 130

106 120 124 131

108 122 126 133

110 124 128 135

111 125 129 136

112 126 130 137

60 75 79 87

60 75 79 87

61 76 80 88

62 77 81 89

63 78 82 90

64 79 83 91

64 79 83 91

14

50th 90th 95th 99th

106 120 124 131

107 121 125 132

109 123 127 134

111 125 128 136

113 126 130 138

114 128 132 139

115 128 132 140

60 75 80 87

61 76 80 88

62 77 81 89

63 78 82 90

64 79 83 91

65 79 84 92

65 80 84 92

15

50th 90th 95th 99th

109 122 126 134

110 124 127 135

112 125 129 136

113 127 131 138

115 129 133 140

117 130 134 142

117 131 135 142

61 76 81 88

62 77 81 89

63 78 82 90

64 79 83 91

65 80 84 92

66 80 85 93

66 81 85 93

16

50th 90th 95th 99th

111 125 129 136

112 126 130 137

114 128 132 139

116 130 134 141

118 131 135 143

119 133 137 144

120 134 137 145

63 78 82 90

63 78 83 90

64 79 83 91

65 80 84 92

66 81 85 93

67 82 86 94

67 82 87 94

17

50th 90th 95th 99th

114 127 131 139

115 128 132 140

116 130 134 141

118 132 136 143

120 134 138 145

121 135 139 146

122 136 140 147

65 80 84 92

66 80 85 93

66 81 86 93

67 82 87 94

68 83 87 95

69 84 88 96

70 84 89 97

Adolescent Medicine: The Requisites in Pediatrics

Age (yrs)

74

Table 12-1 Average Systolic and Diastolic BP Levels in Adolescent Males for the 50th, 90th, 95th, and 99th BP Percentiles Adjusted for Age and Height Percentile



Table 12-2 Average Systolic and Diastolic BP Levels in Adolescent Females for the 50th, 90th, 95th, and 99th BP Percentiles Adjusted for Age and Height Percentiles

Age (yrs)

BP Percentile

Systolic BP (mmHg) Height Percentile

Diastolic BP (mmHg) Height Percentile

5th

10th

25th

50th

75th

90th

95th

5th

10th

25th

50th

75th

90th

95th

11

50th 90th 95th 99th

100 114 118 125

101 114 118 125

102 116 119 126

103 117 121 128

105 118 122 129

106 119 123 130

107 120 124 131

60 74 78 85

60 74 78 85

60 74 78 86

61 75 79 87

62 76 80 87

63 77 81 88

63 77 81 89

12

50th 90th 95th 99th

102 116 119 127

103 116 120 127

104 117 121 128

105 119 123 130

107 120 124 131

108 121 125 132

109 122 126 133

61 75 79 86

61 75 79 86

61 75 79 87

62 76 80 88

63 77 81 88

64 78 82 89

64 78 82 90

13

50th 90th 95th 99th

104 117 121 128

105 118 122 129

106 119 123 130

107 121 124 132

109 122 126 133

110 123 127 134

110 124 128 135

62 76 80 87

62 76 80 87

62 76 80 88

63 77 81 89

64 78 82 89

65 79 83 90

65 79 83 91

14

50th 90th 95th 99th

106 119 123 130

106 120 123 131

107 121 125 132

109 122 126 133

110 124 127 135

111 125 129 136

112 125 129 136

63 77 81 88

63 77 81 88

63 77 81 89

64 78 82 90

65 79 83 90

66 80 84 91

66 80 84 92

15

50th 90th 95th 99th

107 120 124 131

108 121 125 132

109 122 126 133

110 123 127 134

111 125 129 136

113 126 130 137

113 127 131 138

64 78 82 89

64 78 82 89

64 78 82 90

65 79 83 91

66 80 84 91

67 81 85 92

67 81 85 93

16

50th 90th 95th 99th

108 121 125 132

108 122 126 133

110 123 127 134

111 124 128 135

112 126 130 137

114 127 131 138

114 128 132 139

64 78 82 90

64 78 82 90

65 79 83 90

66 80 84 91

66 81 85 92

67 81 85 93

68 82 86 93

17

50th 90th 95th 99th

108 122 125 133

109 122 126 133

110 123 127 134

111 125 129 136

113 126 130 137

114 127 131 138

115 128 132 139

64 78 82 90

65 79 83 90

65 79 83 91

66 80 84 91

67 81 85 92

67 81 85 93

68 82 86 93

Hypertension

75

76

Adolescent Medicine: The Requisites in Pediatrics

Table 12-3 Fourth Report Definitions of Pre-Hypertension, Stage 1 Hypertension, and Stage 2 Hypertension in Children and Adolescents1

Pre-Hypertension Stage 1 Hypertension Stage 2 Hypertension

Lower Limit

Upper Limit

 90th percentile  95th percentile BP  (99th percentile + 5 mmHg)

< 95th percentile < (99th percentile + 5 mmHg)

The lower and upper limits are the BP percentile adjusted for age, gender, and height.

1

Table 12-4 Causes and Associated Physical Findings of Secondary HTN in Children and Adolescents Organ System

Condition

Physical Findings

Renal

Chronic renal failure Renal artery stenosis Polycystic kidney disease Hydronephrosis Multicystic dysplastic kidney Coarctation of the aorta

Growth retardation Epigastric/flank bruit Palpable kidneys

Cardiac

Endocrine

Immunological Neurological Oncological

Williams syndrome Turner syndrome Hyperthyroidism Pheochromocytoma Cushing syndrome Type 2 diabetes mellitus Congenital adrenal hyperplasia Hyperaldosteronism Liddle syndrome Systemic lupus erythematosus Neuroblastoma Tuberous sclerosis Wilms tumor

a­ dolescence are exogenous (e.g., stimulant medications, substance use, hormonal contraception); renal scarring following childhood reflux nephropathy; and endocrine (e.g., hyperthyroidism). Within the renal category, renal artery stenosis is both more common and more correctable in adolescents than adults.  The pathology in adolescents is fibromuscular dysplasia, in contrast to the atherosclerotic intimal hyperplasia of adults. Rare causes of secondary HTN in adolescents include pheochromocytoma, coarctation of the aorta that was not detected in childhood, neurofibromatosis, glucocorticoid-remediable hyperaldosteronism, and 17-alpha-hydroxylase deficiency. Other forms of congenital adrenal hyperplasia (CAH) that are associated with HTN present early in life, and the most common form that presents during adolescence (i.e., partial-21-hydroxylase deficiency) does not cause HTN.

Heart murmur, decreased lower extremity pulses; BP drop from upper to lower extremities Elfin facies Webbed neck, widely spaced nipples Tachycardia, thyromegaly Pallor, flushing, diaphoresis, tachycardia Truncal obesity, moon facies, acne, hirsutism, striae Acanthosis nigricans, truncal obesity Ambiguous genitalia, virilization Muscle weakness Malar rash, arthritis, mental status change Tachycardia, café-au-lait spots Adenoma sebaceum Mass

Evaluation The evaluation of an adolescent with hypertension has four goals: confirmation of the diagnosis; identification of secondary causes; identification of other risk factors for CVD; and determination of treatment.

BP Measurement Instruments and techniques have direct effects on the accuracy of BP measurements. Mercury sphygmomanometers are the most accurate instruments, but their use is decreasing due to concerns about release of mercury into the environment. Aneroid manometers are the recommended alternative but must be recalibrated at least twice yearly.



Hypertension

Oscillometric instruments are used when frequent BP readings are required or auscultation is difficult. Although more convenient than manometry, oscillometric measurements are approximately 10 mmHg higher and vary more across ­ instruments than do manometric measurements. An oscillometric reading ³ 90th percentile therefore should be rechecked by auscultation and manometry. Manometry, regardless of type, requires the use of a cuff that is sized appropriately.  A cuff that is too small may yield a measurement that is falsely high, whereas a cuff that is too wide may yield a measurement that is falsely low.  The width of the cuff bladder should equal approximately 40% of the mid-upper-arm circumference, and the bladder should encircle at least 80% of the limb circumference. Table 12-5 lists the recommended cuff bladder dimensions for children and adults. NHBPEP IV recommends the annual measurement of BP after the adolescent has been seated quietly for at least 5 minutes. The right arm should be positioned at heart level, and the stethoscope should be placed over the brachial artery pulse.  The cuff should be inflated to a pressure 20–30 mmHg above systolic and then deflated at a rate of 2–3 mmHg per heartbeat. The pressure at which the pulse is first heard (i.e., Korotkoff Phase I) is the systolic BP.  The pressure at which the pulse disappears (i.e., Korotkoff Phase V) is the diastolic BP. The measurement should be repeated at 1- to 2-minute intervals until two consecutive measurements differ by no more than 5 mmHg.

History, Physical Examination, and Laboratory Studies The history should focus on the following: adolescent use of medications or illicit drugs associated with hypertension (e.g., stimulant therapy for attention deficit hyperactivity disorder, appetite suppressants, anabolic

steroids); adolescent use of tobacco or alcohol; adolescent snoring or disordered sleep; adolescent diet and activity; and family history of HTN, CVD, and risk factors for CVD.  The physical examination should include body mass index (BMI), heart rate, skin examination for caféau-lait spots, neurofibromas, or other systemic disease; fundoscopic examination; thyroid examination; cardiac examination for murmur, pre-systolic heave, and S4; peripheral vascular examination for abdominal bruit and absent femoral pulses; abdominal examination for palpable kidneys; and genital examination for findings of CAH or other conditions associated with genital and renal anomalies. The standard laboratory evaluation of an adolescent with HTN includes measurement of serum electrolytes, blood urea nitrogen (BUN), creatinine, complete blood count, and thyroid studies; urinalysis; renal ultrasound; and echocardiogram to assess left ventricular mass. In the adolescent with obesity or a family history of early CVD, fasting plasma glucose, insulin, and lipids should also be obtained. Most adolescents will fit the characteristics of essential HTN and will require no additional diagnostic evaluation.

Management The management of Pre-HTN and HTN in children and adolescents is summarized in Figure 12-2. As noted in the algorithm, behavioral interventions to reduce the BP should precede initiation of antihypertensive medications and continue during their administration and/or taper.

Nonpharmacological Therapy Prior to the initiation of pharmacotherapy, NHBPEP IV recommends the following lifestyle modifications for adolescents with Pre-HTN and Stage 1 HTN:  

l

 

l

   

l

Table 12-5 Recommended Dimensions of BP Cuff Bladders for Children and Adolescents BP Cuff Bladder

Child arm Small adult arm Medium adult arm Large adult arm Adult thigh

Limb Maximum Circumference (cm)

Width (cm)

Length (cm)

21 26 34 44 52

 9 10 13 16 20

18 24 30 38 42

77

l

Attainment  and maintenance of a normal weight for height. In overweight children and adults, weight loss reduces systolic pressure, particularly when it is in response to a program of combined diet and aerobic exercise. Aerobic exercise 30–60 minutes daily. Of note, isometric exercise such as weightlifting can raise BP acutely and should be avoided until good control is achieved. Sedentary activity for no more than 2 hours daily. Restriction of daily salt intake to 3.8 gm, which corresponds to a daily sodium intake of 1.5 gm. Although the data are limited in adolescents, salt restriction in normal-weight adults with HTN has been shown to decrease BP.

78

Adolescent Medicine: The Requisites in Pediatrics Measure BP and HT and BMI Determine BP category for age, height, gender

Stage 2 HTN

Stage 1 HTN

Pre-HTN

90– 85th percentile for age and sex Weight for height > 85th percentile Weight > 120% of ideal weight for height

and at least two of the following:      

l l

l

T2DM in a first- or second-degree family member Native American, African-American, Latino, AsianAmerican, or Pacific Islander race/ethnicity Signs of insulin resistance or conditions related to insulin resistance such as acanthosis nigricans, hypertension, dyslipidemia, or polycystic ovary syndrome

Table 13-1 ADA Definitions of Pre-Diabetes and Diabetes Pre-Diabetes

Diabetes

100–125 140–199

 200 with symptoms  126  200

Random plasma glucose (mg/dl) Fasting plasma glucose (mg/dl) OGTT 2-hour plasma glucose (mg/dl)

last caloric intake or a plasma glucose performed 2 hours after consuming 75 grams of anhydrous glucose dissolved in water during an OGTT. Pre-diabetes is defined as an impaired FPG of 100– 125 mg/dl or an impaired glucose tolerance (IGT) at 2 hours of 140–199 mg/dl. The patient with pre-diabetes should be retested at 3 months.

T1DM vs. T2DM The differentiation of T1DM and T2DM is an important goal of the initial evaluation because the diagnosis guides management decisions. In most cases, the correct diagnosis is apparent from the clinical presentation. Patients with T1DM are more likely to be thin and to present with the classic symptoms of diabetes, ketonemia, and ketonuria. In contrast, adolescents with T2DM usually have no evidence of ketone production and rarely present with DKA. They are more likely than adolescents with T1DM to be overweight or obese, to have acanthosis nigricans, and to have a strong family history of diabetes.

In equivocal cases, such as adolescents with obesity and ketonemia, laboratory evaluation can help differentiate T1DM and T2DM. The presence of islet cell antibody, insulin antibody, or GAD65 antibody and a low or undetectable level of plasma C-peptide level suggest T1DM. In T2DM, the level of C-peptide usually is normal or elevated. Regardless of the type of diabetes, the patient who is symptomatic, ketotic, or has a glucose greater than 250 mg/dl requires insulin therapy. The initial use of insulin in a new-onset diabetes patient does not commit the clinician to extended use if subsequently the diagnosis ­suggests T2DM or MODY.

Management of T1DM Early education is a critical component of diabetes management. It must be adapted to the adolescent’s cognitive maturity and should involve all potential caregivers. Discussion and teaching materials should address the causes and consequences of the type of diabetes affecting the patient, the dosing and administration of insulin and/ or other medications, the importance of diet to glucose control, blood glucose testing, the symptoms and management of hypoglycemia, and “sick-day” insulin adjustment. An experienced dietitian should assist with a nutritive dietary plan that meets the individual adolescent’s metabolic needs. All patients should be taught carbohydrate counting, and those with T2DM should be taught to limit and distribute carbohydrate intake throughout the day as part of a weight reduction dietary and exercise plan. One of the first decisions following diagnosis is about inpatient versus outpatient management. The decision rests on many factors in addition to illness severity, including the comfort and collaboration of the patient, family, and clinical team. The outpatient strategy requires a team of health care providers that can share the time-intensive responsibilities of patient and family education, as well as the telephone calls and frequent visits that accompany a new diagnosis. The diabetes team at a tertiary care pediatric center typically includes a diabetes physician, diabetes nurse practitioner/educator, registered dietician, and mental health professional (see Box 13-2).

Insulin An early decision in the management of diabetes is whether to use insulin. Nearly all adolescents who present with DKA have T1DM and require insulin. Although T1DM may enter a honeymoon phase with diminished insulin requirements for up to 1 year, pancreatic beta cell destruction continues and insulin requirements ultimately increase. Conversely, patients with T2DM typically can be managed without insulin. However, intensive short-term insulin therapy beginning at diagnosis of



Diabetes Mellitus

Box 13-2  Diabetes Outpatient Evaluation l

l

l

History l Review of diabetes regimen and side effects l Diabetes complications (e.g. DKA, hypoglycemia) l Diet and exercise adherence l New medical conditions and medications l Review of annual dilated eye examination findings l New family history l Social, sexual, and menstrual history l Diabetes review of systems (polyuria, nocturia, hypoglycemia, weight loss, nausea, abdominal pain, vision changes, hand or foot pain, constipation) l Review blood glucose records Physical Examination l Vital signs l Blood pressure (using appropriate size cuff) l Height, weight, and BMI l General appearance and hygiene l Funduscopic examination l Thyroid palpation l Sexual maturity rating (annually) l Evaluation of pulses l Skin examination l Evidence of acne, hirsutism, or acanthosis nigricans (mainly T2DM patients) l Inspection of insulin injection sites for inflammation or hypertrophy l Inspection of fingers for evidence of blood glucose testing l Foot examination l Neurological examination l Sensation/monofilament testing l Lower extremity deep tendon reflexes Laboratory Evaluation l HbA1C (quarterly) l Recommended screening for complications l TSH (T1DM only): every 1–2 years l Urine microalbumin: annually l Fasting lipid profile: annually if LDL > 100 mg/dl, otherwise every 5 years

85

T2DM, particularly in patients with ketosis or blood ­glucose levels > 250 mg/dl, is associated with improved glycemic control 1 year later. Patients with T2DM ­presenting without symptoms or with blood glucose < 250 mg/dl can be managed with lifestyle modification and oral ­hypoglycemic ­medications as described below. The various types of insulin differ in their time of onset, peak effect, and duration of action (Table 13-2). Conventional insulin therapy refers to regular and neutral protamine Hagedorn (NPH) insulin injected once or twice daily as a premixed or patient-mixed preparation. Intensive insulin therapy refers to more complex regimens in which intermediate- or long-acting insulin is given once or twice daily and rapid-acting insulin is given 15 minutes before or immediately after meals. Compared with regular insulin, lispro and aspart have a more rapid onset and shorter duration of action, allowing correction for preprandial glucose levels and coverage of consumed carbohydrates. Treatment recommendations have called for tighter glycemic control since the Diabetes Control and ­Complications Trial (DCCT) demonstrated 50–76% reductions in microvascular complications with intensive compared with standard insulin therapy. Intensive therapy was defined as insulin by pump or multiple daily injections, with a target HbA1C < 6.0%. Standard therapy was defined as twice-daily insulin injections. Based on the DCCT findings, the ADA recommends preprandial blood glucose levels of 90–130 mg/dl and HbA1C levels of 7.0–7.5% for patients > 13 years with T1DM. The usual total daily dose (TDD) for new-onset diabetes is 0.3–0.7 units/kg/day. Adolescents who are thin and pre-pubertal may require less, whereas those who are heavier or at the peak of puberty may require 1.2–1.5 units/kg/day. The TDD is divided into a basal dose (40–45%) to suppress gluconeogenesis and bolus doses (55–60%) with meals to correct preprandial hyperglycemia and to cover consumed carbohydrates. The basal/bolus regimen can be administered by multiple daily injections or by a continuous subcutaneous insulin infusion (CSII) pump that

Table 13-2  Characteristics of Human Insulin Preparations

Preparation

Action

Lispro, Aspart Regular NPH Detemir1 Glargine

Rapid Short Intermediate Long Long

Onset (hrs)

Peak (hrs)

Effective Duration (hrs)

Maximum Duration (hrs)

0.25 0.5–1.0 2–4 1–2 2–4

1–2 2–3 4–10 8–11 None

2–3 3–6 10–16 12–20 20–24+

4 4–6 14–18 14–22 24–36

Based on 0.2–0.4 U/kg dose range. From Plank J, Bodenlenz M, Sinner F, et al.: A double-blind, randomized, dose-response study investigating the pharmacodynamic and pharmacokinetic properties of the long-acting insulin analog detemir. Diabetes Care 2005;28:1107–1112.

1

86

Adolescent Medicine: The Requisites in Pediatrics

varies the basal rate over a 24-hour period. Both delivery systems, however, require patient determination of the bolus doses. Patients who are unable to manage the dosage adjustments can be managed with twice-daily ­injections of NPH mixed with sliding-scale regular ­insulin. As shown in Table 13-3, the corrective portion of the bolus dose is equal to the difference between the actual and target blood glucose levels divided by a sensitivity factor that estimates the reduction in blood glucose induced by one unit of insulin.  The sensitivity factor for rapid-acting insulin is approximately 1800/TDD. A typical target blood glucose level is 120 mg/dl, and a typical sensitivity factor is 50 mg/dl/unit.  The food portion of the bolus dose is equal to the grams of carbohydrate consumed divided by a coverage factor that estimates the grams of carbohydrate covered by one unit of insulin. The coverage factor for rapid-acting insulin is approximately 500/TDD and typically ranges from 8–15 grams per unit of insulin. Rapid growth, erratic eating, sports participation, and social pressure may complicate insulin management in the adolescent with diabetes. Some of the common problems that arise are discussed next.

Hypoglycemia Hypoglycemia is an important complication of intensively managed T1DM. It is imperative that patients and families recognize and know how to treat it. The symptoms incl­ ude diaphoresis, palpitations, tremulousness, hunger, pallor, drowsiness, confusion, aggressiveness, coma, and seizure. The conscious patient should consume 15 g of a rapidly absorbed carbohydrate (e.g., 3–4 glucose tablets) every 15–20 minutes until the blood glucose is greater than 80 mg/dl. Glucose tablets, hard candy, fruit juice, or other rapidly acting carbohydrate should always be available at home and school. The unconscious patient outside a health care setting should be given glucagon, 0.5–1.0 mg subcutaneously or intramuscularly. This will increase the blood glucose into a safe range but also causes severe nausea within 60–90 minutes that may require intravenous support. The patient within a health care setting should be given 50% dextrose, 25–50 g intravenously.

Table 13-3 Calculation of Insulin Total Daily Dose (TDD) TDD Bolus dose Food dose Corrective dose

Basal dose + bolus doses Food dose + corrective dose Carbohydrate (500/TDD) (Actual blood glucose − target blood glucose) / (1800/TDD)

The risk of hypoglycemia is particularly high in the contexts of autonomic neuropathy, beta blocker therapy, excessive exercise, and eating disorders. Patients with autonomic neuropathy may lose the counter-regulatory response to hypoglycemia and, like those on beta blockers, may not manifest the symptoms of hypoglycemia until it is severe. Exercise, although recommended for all patients with diabetes, may deplete hepatic glycogen in T1DM. Blood glucose therefore should be monitored in athletes with T1DM before, every hour during, and ­immediately after exercise. The optimal range for blood glucose during exercise is 150–250 mg/dl. Exercise should be avoided if the blood glucose is > 350 mg/dl or > 250 mg/dl with ketonuria. If the blood glucose is < 100 mg/dl, the adolescent should rest, consume an electrolyte sport drink containing 15 g carbohydrate, and recheck the blood glucose in 15 minutes. Athletes participating in strenuous or prolonged events typically require 15 g carbohydrate for every 30 minutes of exercise, and some may require a drop in the insulin dose before exercise. Most importantly, coaches must be aware of the adolescent’s risk and must be educated about the signs and management of hypoglycemia.

Dawn and Somogyi Effects The dawn and Somogyi effects both present as early morning hyperglycemia in patients on insulin. However, the two effects differ in their causes and treatment. The dawn effect is caused by the early morning release of cortisol, growth hormone, and catecholamines. It is managed by increasing the evening insulin dose and testing the blood glucose at 2:00 to 3:00 a.m. to avoid hypoglycemia. The Somogyi effect is rebound hyperglycemia secondary to early morning hypoglycemia. It is managed by reducing the evening insulin dose and testing the blood ­glucose at 2:00 to 3:00 a.m. to avoid hyperglycemia.

Sick-Day Insulin Sick-day management is a standard component of patient and family education about diabetes. Sick days are times of physiological stress typically caused by infection, other illness, injury, and significant emotional distress. Correc­ tive doses of rapid-acting insulin may be administered up to every 2–3 hours to control hyperglycemia. Blood glucose should be tested frequently and, if > 250 mg/dl, urine should be tested for ketones. Trace to moderate ketonuria should be treated orally with glucose-free liquids. Large ketonuria requires rapid-acting insulin in doses 10–20% greater than those given to reduce hyperglycemia. If vomiting or the underlying illness prevents oral hydration and/or glucose monitoring, the adolescent should be directed to seek medical attention.



Diabetes Mellitus

New Therapies for T1DM

Oral Pharmacotherapy

An inhaled insulin preparation with pharmacodynamics similar to rapid- and short-acting parenteral insulin is likely to be approved for use in adults with TIDM. Whole or segmental pancreas transplantation has demonstrated cure rates of 80–90% but involves major surgery and ­lifelong immunosuppression. Islet cell transplantation involves less risk due to its minimally invasive nature but appears less successful. Other attempts for a cure, such as beta cell regeneration and insulin gene therapy, are ­currently being explored.

Management of T2DM Lifestyle Modification Weight reduction and exercise are the cornerstones of therapy for most patients with T2DM and pre-diabetes. Dietary fat and carbohydrates should comprise < 25% and 45–65% of total daily kilocalories (kcals), respectively, and total kcals should be adjusted to attain and/ or maintain an ideal body weight for height. A low­carbohydrate diet (< 130 g/d) is not recommended for adolescents because of the risk of hypoglycemia. Exercise, at approximately 150 minutes weekly, is recommended because it increases calorie expenditure, facilitates glucose transport into skeletal muscle, and improves ­glycemic control. The decrease in microvascular complications noted in the DCCT for T1DM was also noted in the United Kingdom Prospective Diabetes Study for T2DM. Consequently, the goals of treatment are the same as those noted above for T1DM. In general, T2DM patients with HbA1C levels > 8% after 3 months of lifestyle modification should progress to pharmacological therapy.

Table 13-4  Oral Hypoglycemic Agents First-generation sulfonylureas

Second-generation sulfonylureas

Biguanide Glucosidase inhibitors Thizolidinediones Meglitinides

87

Acetohexamide Chlorpropamide Tolbutamide Glipizide Glyburide Glimepride Metformin Acarbose Miglitol Rosiglitazone Pioglitazone Repaglinide Nateglinide

The classes of oral hypoglycemic agents and the drugs within each class are shown in Table 13-4. Metformin, a buiguanide, has been shown to be safe and effective for pediatric use and is considered first-line pharmacotherapy for adolescents with T2DM. In addition to increasing muscle sensitivity to insulin, metformin increases hepatic glucose production and reduces total and LDL cholesterol. Side effects are primarily gastrointestinal (e.g., nausea, diarrhea, abdominal pain) and usually resolve with continuation of therapy. Hypoglycemia is uncommon, and lactic acidosis is extremely rare. Metformin is begun at 500 mg once daily and is increased by 500 mg every 1–2 weeks to a maximum daily dose of 2500 mg. However, 80% of the hypoglycemic effect occurs at 1500 mg daily. Patients who remain hyperglycemic after 6–8 weeks at this dose should either start another oral hypoglycemic agent in addition to metformin or should be started on insulin and tapered off metformin. Sulfonylureas and meglitinides enhance the release of insulin from the pancreatic beta cells. The key side effect of the sulfonylureas is weight gain, which may perpetuate insulin resistance, whereas the meglitinides may induce hypoglycemia if a meal is not eaten after a dose. Glucosidase inhibitors delay the intestinal absorption of ingested carbohydrate and are given before meals to reduce postprandial hyperglycemia. Gastrointestinal side effects are controlled by slow increase of the dose and frequency, to a maximum of three times daily. The use of thiazolidinediones is controversial. In one study of adults, rosiglitazone was associated with increased risk of cardiovascular disease. They are also associated with hepatotoxicity. They are not recommended for adolescents at this time.

Common Issues in the Management of Adolescents with Diabetes The management of diabetes during adolescence involves adjustments for changes in body size and composition, energy demand and intake, and cognitive and social maturation. As development progresses, glycemic regulation typically shifts from parent to adolescent. Families that struggle with this transition may benefit from increased clinician involvement, more frequent office visits, and advance discussion about the eventual transfer of care from the pediatric to adult settings. In addition to these expected developmental processes, the management of diabetes may be complicated by comorbid conditions or behavioral issues such as those described next. Eating disorders are more common among adolescents with than those without diabetes, and concurrent T1DM and anorexia nervosa carries a higher mortality than either disease alone. The risk may reflect hyperglycemia

88

Adolescent Medicine: The Requisites in Pediatrics

secondary to the omission or reduction of insulin in an effort to lose weight; hypoglycemia secondary to inadequate intake or excessive exercise; or electrolyte imbalance secondary to purging. Regardless of body weight, all adolescents with diabetes should be screened for eating disorders (see Chapter 35). Accurate weights should be obtained at all visits, and excessive fluctuation or steady decline should trigger further evaluation. Early recognition and intervention can be life-saving, particularly in an adolescent with recurrent DKA or poor glycemic control. Whenever possible, referral should be made to registered dieticians and mental health providers who are experienced with adolescents, eating disorders, and diabetes. Alcohol use by adolescents with T1DM may contribute to hypoglycemia by inhibiting gluconeogenesis and blunting counter-regulatory mechanisms. Alcohol is not metabolized to glucose, and alcoholic beverages should not be included in carbohydrate counting. The adolescent who does drink alcohol should consume additional carbohydrates prior to drinking, test blood glucose frequently during the subsequent 8–12 hours, and notify others about their diabetes and the possibility of alcoholinduced hypoglycemia. Drinking and driving are always contraindicated and are of heightened concern when the driver is inexperienced, inebriated, and at risk for ­hypoglycemia. Driving and hypoglycemia is a dangerous combination. All patients with T1DM should test blood glucose prior to driving, have a rapid-acting source of glucose in the vehicle, and wear a diabetes bracelet or necklace. Pregnancy in women with poor glycemic control is associated with increased rates of macrosomia and congenital anomalies. Adolescent females with diabetes should be educated about the risk of fetal malformation and the importance of planned, monitored pregnancies. Sexually active adolescent females who do not intend pregnancy should be encouraged to use hormonal contraception in addition to condoms for protection against sexually transmitted infection. If pregnancy is desired, it is recommended that glycemic control be optimized and medications such as angiotensin-converting enzyme (ACE) inhibitors/receptor blockers and statins be discontinued. The discontinuation of oral hypoglycemic agents and the initiation of insulin during pregnancy is generally recommended.

Outcome Microvascular and Macrovascular Disease Poor glucose control is a strong predictor of microvascular and cardiovascular disease both in T1DM, as discussed earlier, and in T2DM. The United Kingdom Prospective Diabetes Study demonstrated that a 1% decrease in HbA1C in patients with T2DM was associated with a 35% decrease in microvascular disease and an 18% decrease in myocardial infarction. Although macrovascular complications such as myocardial infarction and stroke are rare in the adolescent age group, predisposing conditions such as obesity, dyslipidemia, and hypertension are common and should be controlled. In light of the strong and consistent associations between glycemic control and outcome in both T1DM and T2DM, intensive therapy is recommended for all patients with diabetes, regardless of disease type or patient age. In addition, all patients with diabetes should be screened yearly for retinopathy, nephropathy, and neuropathy. Diabetic retinopathy is the leading cause of new blindness among individuals aged 20–74 years. Nephropathy occurs in 20–40% of diabetes patients and is the leading cause of end-stage renal disease. An annual dilated funduscopic examination should be performed by an ophthalmologist experienced with diabetic retinopathy. A random urine sample or 24-hour urine collection should be screened for microalbumin. A random result greater than 30 mcg/mg creatinine or a 24-hour result > 30 mg is abnormal and should be repeated. Regardless of the presence or absence of hypertension, ACE inhibitors are the first-line therapy for adolescents with microalbuminuria. The dose should be optimized to a goal of normal microalbumin excretion, and serum potassium should be monitored for hyperkalemia. Symptomatic neuropathy (painful diabetic foot, autonomic neuropathy, gastroparesis) is uncommon in adolescents. Nevertheless, a careful history, foot examination, and neurological examination (including deep tendon reflexes and sensation) are ­recommended.



Diabetes Mellitus

 l

l

l

l

l

l

l

l

Major Points

b

Both T1DM and T2DM are increasing in incidence in the adolescent population. T1DM is primarily caused by autoimmune pancreatic beta cell destruction. T2DM is due to the effects of insulin resistance, often associated with obesity. Diabetes is diagnosed by a random plasma glucose greater than 200 mg/dl and clinical symptoms of ­diabetes; fasting plasma glucose greater than 126 mg/dl; or 2-hour post-OGTT plasma glucose greater than 200 mg/dl. Management depends on the presence and severity of symptoms and type of diabetes. Intensive insulin therapy of T1DM patients ­involving multiple daily injections delays the onset of ­microvascular complications. Lifestyle modification is the foundation in the ­treatment of T2DM. The preferred initial oral ­hypoglycemic agent for adolescents is metformin. Patients with diabetes require appropriate ­screening for complications and common comorbidities of adolescence, such as eating disorders and alcohol use. As adolescents progress into adulthood, they should gradually assume more of the responsibilities of diabetes care until they are capable of self-management.

89

Bibliography American Diabetes Association: Clinical Practice Recom­ mendations 2005. Diabetes Care 2005;28(Suppl 1):S1–79. CDC National Estimates on Diabetes. Available from: http:// www.cdc.gov/diabetes/pubs/factsheet.htm. Accessed October 17, 2005. DCCT Research Group. Diabetes Control and Complications Trial (DCCT): The effects of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Eng J Med 1994;329: 977–986. Gale EA: The rise of childhood Type 1 diabetes in the 20th century. Diabetes 2002;51:3353–3361. Gianani R, Eisenbarth GS: The stages of Type 1A diabetes: 2005. Immunol Rev 2005;204:232–249. Jones KL, Arslanian S, Peterokova VA, et al.: Effect of metformin in pediatric patients with Type 2 diabetes: A randomized controlled trial. Diabetes Care 2002;25:89–94. Pinhas-Hamel O, Zeitler P: The global spread of Type 2 diabetes mellitus in children and adolescents. J Pediatr 2005;146: 693–700. Silverstein J, Klingensmith G, Copeland K, et al.: Care of children and adolescents with Type 1 diabetes: A statement of the American Diabetes Association. Diabetes Care 2005;28: 186–212. Ryan EA, Imes S, Wallace C: Short-term intensive insulin therapy in newly diagnosed Type 2 diabetics. Diabetes Care 2004;27:1028–1032. Stumvoll M, Goldstein BJ, van Haeften TW: Type 2 diabetes: Principles of pathogenesis and therapy. Lancet 2005;365: 1333–1346. Zinman B, Ruderman N, Campaigne BN, et al.: Physical activity/ exercise and diabetes. Diabetes Care 2004;27(Suppl 1):S58–62.

14

C h Ap t e r

Introduction Pathophysiology Screening and Evaluation Screening Evaluation

Management Diet and Behavior Pharmacotherapy

Outcome

Introduction Dyslipidemia is a prerequisite to the development of atherosclerotic cardiovascular disease. Only in populations with lifelong hypocholesterolemia is a near absence of clinical coronary heart disease (CHD) observed. As with blood pressure, lipid levels track through childhood. Autopsy studies have consistently demonstrated the adolescent onset of the atherosclerotic process, and the Bogalusa Heart Study has confirmed the strong association between antemortem cholesterol levels and postmortem atherosclerosis in adolescents and young adults. The prevention of cardiovascular disease in adulthood begins with the diagnosis and treatment of dyslipidemia in childhood and adolescence. After brief reviews of the prevalence and causes of dyslipidemia, this chapter focuses on the recommendations for screening and an evidence-based approach to the management of dyslipidemia in adolescents.

Pathophysiology The classification of the dyslipidemias is transitioning from an older system based on phenotype to a newer system based on genetic or metabolic mechanism. Each system has gaps and overlaps, and the transition further 90

Hyperlipidemia Elaine M. Urbina, MD Stephen R. Daniels, MD, PhD

complicates efforts to organize the causes and manifestations of dyslipidemia. As the pathophysiology of dyslipidemias is clarified, one system is likely to emerge in which the underlying mechanism explains the phenotypic pattern observed on lipoprotein analysis. Most hyperlipidemia is caused by genetic polymorphism in the context of dietary and other lifestyle factors. Identifiable familial forms account for less than 2% of all hyperlipidemia yet carry the highest cardiovascular risk. Other causes, such as those listed in Table 14-1, can usually be identified by a careful history, physical examination, standard laboratory testing (i.e., thyroid, renal, and liver function studies, and urinalysis). Familial hypercholesterolemia (FH) is due to mutations in the low-density lipoprotein-cholesterol (LDL-C) receptor gene and represents the most common single-gene disorder of lipoprotein metabolism. It has an autosomal co-dominant pattern of transmission and a population prevalence of 0.1– 0.5%. Individuals who are heterozygous and homozygous for FH have LDL-C levels that are two to three and five to six times normal, respectively. FH corresponds to types IIa and IIb in the phenotypic system of classification. Cholesterol deposits are common in the tendons (xanthomas) and eyelids (xanthelasmas) in the homozygous form, but are rare before adulthood in the heterozygous form. Endothelial dysfunction begins during childhood in individuals with FH, and the risk of premature CHD during adulthood is markedly increased over the general population. Familial combined hyperlipidemia (FCH) is characterized by genetic and metabolic heterogeneity, even among members of a single family. It has a population prevalence of 0.5– 1.0%, making it a relatively common cause of dyslipidemia in children and adolescents. The usual manifestations are a modestly elevated LDL-C level, elevated very-low-density lipoprotein-cholesterol (VLDL-C) and triglyceride (TG) levels, and low high-density lipoprotein cholesterol (HDL-C). It overlaps with FH in the phenotypic classification system, presenting as IIa, IIb, IV, and rarely V.



Hyperlipidemia

familial lipoprotein lipase deficiency, and familial dysbetalipoproteinemia, are exceedingly rare.

Table 14-1 Causes of Hypercholesterolemia Exogenous

Endocrine

Storage diseases

Gastrointestinal

Renal

Other

91

Corticosteroids, anabolic steroids, isotretinoin, thiazide diuretics, anticonvulsants, beta blockers, estrogen, anti-retrovirals Alcohol Obesity Ketogenic diets Hypothyroidism Cushing syndrome Hypopituitarism Diabetes mellitus Lipodystrophy Pregnancy Glycogen storage diseases Gaucher disease Cystine storage disease Tay-Sachs disease Neumann-Pick disease Acute intermittent porphyria Cholestasis Hepatitis Cirrhosis Pancreatitis Nephrotic syndrome Renal failure Hemolytic uremic syndrome Anorexia nervosa Malnutrition Anorexia nervosa Idiopathic hypercalcemia Progeria Systemic lupus erythematosus

Familial hypertriglyercidemia follows an autosomal dominant inheritance pattern, but its expression is heavily influenced by diet and physical activity. The other inherited dyslipidemias, such familial defective apoB,

Screening and Evaluation Screening The 1992 Report of the National Cholesterol Education Program (NCEP) Expert Panel on Blood Cholesterol Levels in Children and Adolescents provided the first guidelines for lipid screening during childhood. In 1998, the American Academy of Pediatrics (AAP) issued a Policy Statement that has served to update the NCEP Report (see Figure 14-1). Based on current evidence, children and adolescents younger than 20 years of age should have lipoprotein analysis performed after a 12-hour overnight fast if they have any of the following: l l

l

Parent with elevated blood cholesterol ≥ 240 mg/dl. Parent or grandparent £ age 55 who had docu­ mented myocardial infarction, angina pectoris, documented coronary atherosclerosis, peripheral vascular disease, cerebrovascular disease, or sudden cardiac death. This includes parents/grandparents who had balloon angioplasty or coronary artery bypass surgery. Unknown family history or multiple risk factors for future cardiovascular disease (smoking, hypertension, obesity, diabetes, excessive consumption of saturated fats and cholesterol). Screening in these circums­ tances is at the discretion of a physician.

Although the fasting lipid panel is the best screen, it is better to obtain a total cholesterol (TC) measurement on a nonfasting sample than to obtain no sample in a patient who will have difficulty returning for the

Parent TC ≥240

FH of CVD

Nonfasting TC

Fasting LDL-C

Figure 14-1 Selective lipid screening of individuals aged 2–20 years based on parent level of total cholesterol (TC) and family history (FH) of cardiovascular ­disease (CVD) in a parent or grandparent before age 55 years. Levels for TC and LDL-C are in mg/dl.

240

< 110 110–130 > 130

HDL-C (mg/dl)

Age ≥ 20 Age ≥ 20 < 130 130–160 > 160

> 35 < 35

1 As defined by the NCEP Expert Panel on Blood Cholesterol in Children and Adolescents and the NCEP Adult Treatment Panel.

physical activity. The physical examination should ­inc­lude height, weight, and calculation of the body mass index (BMI; see Chapter 11); Tanner stages to assess pubertal progression (see Chapter 1); blood pressure; inspection of the skin, eyes, and tendons for lipid deposition; palpation of the thyroid gland; and palpation of the liver. If the screening lipoprotein analysis reveals an LDL-C in the borderline or high range, a second fasting lipoprotein analysis should be performed and the two sets of results should be averaged.

Management Diet and Behavior

Serum total cholesterol (mg/dl)

240 220 200 180 160 140 120 100 4–5

6–8

9–11

12–15

16–19

Age (years) 5% 10% 50% 90% 95%

Figure 14-2 Percentiles for serum total cholesterol levels in U.S. children by age. From NHANES III (1988–1994).

The population-based approach to lipid levels is a primary preventive measure designed to lower the lipid levels of the entire population through recommended changes in nutrient intake and eating patterns. The guidelines apply to all facets of food delivery, including schools, health professionals, government agencies, the food industry, and mass media. The dietary recommendation to increase consumption of fruits, vegetables, complex carbohydrates, and low-fat dairy products apply lifelong after age 2 years, particularly as the Dietary Intervention Study in Children has demonstrated the safety of a low-fat diet in growing children. On an individual basis, regardless of the cause of the dyslipidemia, lifestyle changes are the initial approach to treatment. For adolescents with an LDL-C in the acceptable range, education on heart-healthy lifestyles should include discussion of diet, exercise, tobacco, and regular blood pressure checks. For adolescents with LDL-C measurements in the borderline range, evaluation and treatment of other cardiovascular risk factors should be performed, a step-one diet should be initiated (Table 14-3), and lipoprotein analysis should be repeated at 3 months.



Hyperlipidemia 0.75 7.5

93

*

* 0.725

diovascular (CV) risk factors on subclinical atherosclerosis. Brachial artery distensibility decreases and common carotid artery intima-media thickness (IMT) increases with clustering of risk factors. *Linear trend p < 0.02.

Common carotid artery IMT (mm)

Figure 14-3 Effect of multiple car-

Brachial distensibility (% ∆/mmHg)

7

6.5 6

5.5

0.7 0.675 0.65 0.625 0.6

5 0

1

2

3

4+

Number of CV risk factors

If the LDL-C is in the high-risk range, a step-two diet should be prescribed. Nutritional counseling by a registered dietician is important both for adherence and to ensure adequate intake of nutrients, vitamins, and minerals. If the HDL-C is low or TGs are high, the adolescent should be encouraged to substitute complex carbohydrates for sugars and other simple carbohydrates.

Pharmacotherapy Even with strict adherence to diet, only a 10–15% reduction of LDL-C can be expected. If the LDL-C remains 190 mg/dl or higher after 3 months of nonpharmacological measures, the NCEP guidelines suggest that drug therapy be considered. However, for the adolescent with a family history of premature cardiovascular disease or the adolescent with two or more other risk factors, medication can be initiated for persistent LDL-C levels of 160 mg/dl or greater. Repeat laboratory evaluation is recommended 6 weeks after starting drug therapy and every 3 months thereafter until LDL-C goals are reached, after which ­follow-ups decrease to every 6–12 months.

0

1

Recommended Intake

Calories Total fat Saturated fat Polyunsaturated fat Monounsaturated fat Cholesterol Carbohydrates Protein

3+

At the time that the guidelines were published, the bile acid sequestrants constituted the only drug class with published efficacy and safety data for the treatment of dyslipidemias in children and adolescents (Table 14-4). These agents bind bile acids in the intestine, preventing their enterohepatic re-uptake and resulting in their removal from the cholesterol pool. The starting dose is generally one packet or scoop (4 g cholestyramine or 5 g colestid) mixed in 8 oz. of liquid once or twice daily. Dosing is based on initial LDL-C level rather than on body weight (see Table 14-3). Doses greater than 8 g per day rarely improve efficacy and may increase side effects. The most common adverse effects are gastrointestinal, including constipation. These agents may increase TG levels and may interfere with the absorption of certain medications and fat soluble vitamins. Supplementation with a multivitamin and folate (1 mg daily) is therefore usually recommended. Although compliance in many studies is noted to be poor, this class of medication is quite safe and can achieve LDL-C reductions of 13–20%. The 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase inhibitors, or statins, have become the

Table 14-3  Step-One and Step-Two Diets for Hypercholesterolemia

Step One

2

Number of CV risk factors

Step Two

Appropriate for normal growth. Avoid energy imbalance. < 30% total calories < 10% total calories < 7% total calories Up to 10% total calories Remainder of fat calories < 300 mg/day < 200 mg/day ≈55% total calories ≈15–20% total calories

94

Adolescent Medicine: The Requisites in Pediatrics

Table 14-4  Pharmacotherapy for Dyslipidemias Class

Drug

Starting Daily Dose

Maximum Daily Dose

Lipid Effects

Side Effects

Bile acid–binding resins

Cholestyramine Colestipol

4 g or 80 mg/kg 5g

Lowers LDL-C Raises TG

Abdominal bloating Abdominal cramping Constipation

Colesevelam

3750 mg

Nicotinic acid

Niaspan

500 mg @ HS

Once daily if LDL   280 4375 mg (use in children not established) 2000 mg (10 mg/kg/day) @ HS

Lowers LDL-C Lowers TG

HMG CoA reductase inhibitors

Atorvastatin

10 mg

Fluvastatin

20 mg

Flushing Headache Pruritus Transaminase elevation Myositis/CPK elevation Rhabdomyolysis Transaminase elevation

Lovastatin Pravastatin Rosuvastatin

10 mg 10 mg 5 mg

Simvastatin Ezetimibe

5 mg 10 mg

Bezafibrate

200 mg TID

Clofibrate

500 mg BID

Fenofibrate

48 mg

Gemfibrozil

600 mg BID

Omacor

2 g BID

Cholesterol absorption inhibitors Fibric acid derivatives

Omega-3 fatty acids

80 mg (adults) 20 mg (children) 80 mg (use in children not established) 80 mg (10–40 mg in children) 80 mg (10–40 mg in children) 40 mg (use in children not established) 80 mg (5–40 mg in children) 10 mg

200 mg TID 5–10 mg/kg/day in children 500 mg QID (use in children not established) 145 mg 5 mg/kg/day in children 600 mg BID (use in children not established) 2 g BID (use in children not established)

agents of choice for the pharmacotherapy of hypercholesterolemia in children and adults. Statins reduce LDL-C levels by inhibiting the rate-limiting step in the endogenous synthesis of cholesterol and have been shown to reduce cardiovascular mortality in adults. As shown in Figure 14-4, research has also demonstrated improvements in the vascular status of children with dyslipidemias who were treated with statins. Adverse effects are infrequent in adolescents, but liver transaminases and creatinine kinase (CK) should be monitored and patients should be aware of the risk and signs of myositis. Concomitant administration with cyclosporine, erythromycin, and gemfibrizol may increase the risk of rhabdomyolysis and should be avoided. Female patients should be advised that statins are contraindicated in pregnancy. Nicotinic acid (niacin) is a water-soluble B vitamin that lowers cholesterol when administered in high dose. Niacin acts by decreasing liver synthesis of TGrich VLDL-C particles, with resulting decreases in serum levels of VLDL-C, LDL-C, and Lipoprotein (a) [Lp(a)]. Although one study has demonstrated its

Lowers LDL-C Lowers TG Raises HDL-C

Lowers LDL-C

Lowers TG Raises HDL-C

Dyspepsia Constipation, myositis, anemia

Lowers TG

Gastrointestinal

e­ fficacy in children, the high incidence (76%) of bothersome side effects (e.g., flushing, headache, nausea, glucose intolerance, myopathy, hyperuricemia, abnormal liver function) has resulted in limited pediatric use. Extended-release formulations diminish, but do not abolish, the vasomotor symptoms. Fibric acid derivates, or fibrates, (i.e., fenofibrate, clofibrate, gemfibrizol) increase hepatic fatty acid ­oxidation, resulting in lowering TG levels, and increase production of apo-AI and apo-AII, resulting in higher HDL-C levels. Side effects are mostly minor gastrointestinal complaints, but cholelithiasis, abnormal liver function, and myopathy are associated with fibrate use. For this reason, fibrates and HMG-CoA reductase inhibitors should not be used simultaneously. Although one pediatric study demonstrated that fibrates were well tolerated and efficacious in children, the cut-points for initiating therapy are unc­ lear. Adult guidelines recommend initiation at an HDL-C level below 40 mg/dl and/or a TG level above 200 mg/dl. However, because the major risk of TG elevation (i.e., pancreatitis) does not increase substantially until the TG



Hyperlipidemia

Figure 14-4 Improvement in vas-

18

0.5

*

Carotid IMT (mm) with Pravastatin Rx

16 Brachial FMD (%) with Simvastatin Rx

cular status with statin therapy in children with dyslipidemia. Treat­ ment with simvastatin led to return of brachial flow-mediated dilation (FMD) to levels found in normal children. Pravastain, but not placebo treatment, resulted in regression of common carotid intima-media thickness (IMT). p < 0.05 for difference in change from baseline.

14 12 10

95

*

0.495

0.49

0.485

8 0.48

6 Pre

After Rx

reaches 1000 mg/dl, many experts withhold fibrate use in children until the TG is persistently above 350 mg/dl or a random level is above 700 mg/dl. Omega-3 fatty acids, as found in fish oil, are known to reduce TG levels. Although well-tolerated in adults, pediatric data on their use are not available. The newest drug class consists of the cholesterol absorption inhibitors. Ezetimibe prevents the absorption of dietary cholesterol in the small intestine, does not appear to have side effects exceeding those of placebo, and does not increase the risk of myositis when used concomitantly with the statins. There are little data on its use in children and adolescents, but the findings in adults are encouraging.

Normals

After Rx

Placebo

t­ rials along with limited pediatric data suggest that early treatment of risk factors, including dyslipidemia, can lead to improvements in target-organ function.

 l

l

l

Outcome Adult studies clearly demonstrate the effectiveness of lipid-lowering therapy for the primary and secondary prevention of cardiovascular disease. However, even in adults, randomized trials have not included subjects with frequently seen lipid patterns, such as those with acceptable TC and low HDL-C levels or those with high TG levels. In the Framingham Heart Study, 40% of male and 80% of female subjects had lipid profiles that were not included in the randomized trials, and 25% of male and 66% of female subjects with CHD would have been ineligible for the trials. Although the long-term effects of treatment during childhood and adolescent remain unclear, shortterm effects have been reported following medical therapy. In children with dyslipidemia, diet and exercise, antioxidants and statins, and folic acid have been shown to improve vascular function in the settings of obesity, FCH, and diabetes mellitus, respectively. In summary, adolescents who are at increased risk for adult cardiovascular disease can be easily identified with simple measurements of anthropometrics, blood pressure, lipids, and carbohydrate metabolism. Adult ­ treatment

Before

l

l

l

l

l

Major Points

b

Dyslipidemia is a prerequisite to the development of atherosclerosis. Ongoing declines in adult cardiovascular mortality over time depend on the prevention, identification, and treatment of dyslipidemia during childhood and adolescence. Most hyperlipidemia is caused by genetic polymorphisms in the setting of obesity, high-fat diet, and/or sedentary lifestyle. Identifiable familial forms of hyperlipidemia account for 2% of all hyperlipidemia cases yet carry the highest risk of premature cardiovascular disease. Most causes of secondary hyperlipidemia can be identified by measurement of serum thyroid stimulating hormone (TSH), renal function, liver function, and urinalysis. A screening lipoprotein analysis following a 12-hour fast should be performed prior to age 20 years for individuals whose parent has a TC level > 240 mg/dl, or whose parent or grandparent has evidence of cardiovascular disease by age 55 years. Lipid risk categories in individuals younger than age 20 years are defined as acceptable (LDL-C < 110 mg/ dl), borderline (LDL-C = 110–129); and high risk (LDL-C > 130 mg/dl). Management of dyslipidemia begins with changes in diet and physical activity. The step-one diet is recommended for all individuals from age 2 years onward. The step-two diet is recommended for children and adolescents in the high-risk lipid category. Statins are the agents of choice for adolescents with LDL-C levels > 190 mg/dl or > 160 in the presence of two or more other cardiovascular risk factors.

96

Adolescent Medicine: The Requisites in Pediatrics

Bibliography American Academy of Pediatrics. Committee on Nutrition: Cholesterol in childhood. Pediatrics 1998;101(1Pt 1):141–147. American Academy of Pediatrics. National Cholesterol Education Program: Report of the Expert Panel on Blood Cholesterol Levels in Children and Adolescents. Pediatrics 1992;89(3 Pt 2):525–584. Bao W, Srinivasan SR, Wattigney WA, et al.: Usefulness of child­ hood low-density lipoprotein cholesterol level in predicting adult dyslipidemia and other cardiovascular risks. The Bogalusa Heart Study. Arch Intern Med 1996;156:1315–1320. Belay B, Belamarich P, Racine AD: Pediatric precursors of adult atherosclerosis. Pediatr Rev 2004;25:4–16. Berenson GS, Srinivasan SR, Bao W, et al.: Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med 1998;338:1650–1656. Boyd GS, Koenigsberg J, Falkner B, et al.: Effect of obesity and high blood pressure on plasma lipid levels in children and adolescents. Pediatrics 2005;116:442–446. de Graaf J, Stalenhoef AF: Defects of lipoprotein metabolism in familial combined hyperlipidaemia. Curr Opin Lipidol 1998;9:189–196. de Jongh S, Lilien MR, op’t Roodt J, et al.: Early statin therapy restores endothelial function in children with familial hypercholesterolemia. J Am Coll Cardiol 2002;40:2117–2121. Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma without the use of the preparative ultracentrifuge. Clin Chem 1972;18:499–502. Garg R, Vasamreddy CR, Blumenthal RS: Non-high-density lipoprotein cholesterol: Why lower is better. Prev Cardiol 2005;8:173–177. Hickman TB, Briefel RR, Carroll MD, et al.: Distributions and trends of serum lipid levels among United States children and adolescents ages 4–19 years: Data from the Third National Health and Nutrition Examination Survey. Prev Med 1998;27:879–890. Kant AK: Reported consumption of low-nutrient-density foods by American children and adolescents: Nutritional and health correlates, NHANES III, 1988 to 1994. Arch Pediatr Adolesc Med 2003;157:789–796. Kwiterovich PO, Jr: Safety and efficacy of treatment of children and adolescents with elevated low density lipoprotein levels

with a step two diet or with lovastatin. Nutr Metab Cardiovasc Dis 2001;5:30–34. Kwiterovich PO, Jr: State-of-the-art update and review: Clin­ ical trials of lipid-lowering agents. Am J Cardiol 1998;82: 3U–17U, discussion 39U–41U. McGill HC, Jr, McMahan CA, Zieske AW, et al.: Associations of coronary heart disease risk factors with the intermediate lesion of atherosclerosis in youth. The Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Arterioscler Thromb Vasc Biol 2000;20:1998–2004. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III): Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106:3143–3421. Newman TB, Garber AM: Cholesterol screening in children and adolescents. Pediatrics 2000;105:637–638. Studer M, Briel M, Leimenstoll B, et al.: Effect of different antilipidemic agents and diets on mortality:A systematic review. Arch Intern Med 2005;165:725–730. Tracy RE, Newman WP, 3rd, Wattigney WA, et al.: Risk factors and atherosclerosis in youth autopsy findings of the Bogalusa Heart Study. Am J Med Sci 1995;310(Suppl 1):S37–S41. Urbina EM, Kieltkya L, Tsai J, et al.: Impact of multiple cardiovascular risk factors on brachial artery distensibility in young adults: The Bogalusa Heart Study. Am J Hypertens 2005;18:767–771. Urbina EM, Srinivasan SR, Tang R, et al.: Impact of multiple coronary risk factors on the intima-media thickness of different segments of carotid artery in healthy young adults (The Bogalusa Heart Study). Am J Cardiol 2002;90:953–958. Wiegman A, Hutten BA, de Groot E, et al.: Efficacy and safety of statin therapy in children with familial hypercholesterolemia: A randomized controlled trial. JAMA 2004;292:331–337. The Writing Group for the DISC Collaborative Research Group: Efficacy and safety of lowering dietary intake of fat and cholesterol in children with elevated low-density lipoprotein cholesterol. The Dietary Intervention Study in Children (DISC). JAMA 1995;273:1429–1435. Woo KS, Chook P, Yu CW, et al.: Effects of diet and exercise on obesity-related vascular dysfunction in children. Circulation 2004;109:1981–1986.

15

C h Ap t e r

Introduction Epidemiology Pathophysiology Evaluation Management

Acne Michele L. Zucker, MD, MPH

males. One-third of adult females with acne have hyperandrogenicity, and half have a family history of adult acne.

Pathophysiology Introduction Acne vulgaris is the most common skin disorder in the United States, affecting 85% of adolescents and accounting for 10% of primary care visits. Along with the scarring that can follow inflammatory lesions, the adverse effects on self-esteem and psychosocial functioning that begin in adolescence can persist lifelong. This chapter reviews the epidemiology, pathophysiology, psychosocial impact, evaluation, and treatment of adolescent acne. Effective management begins with a thorough history and physical examination and an ability to educate patients and families about the facts and fiction surrounding acne. An understanding of the factors that cause, exacerbate, and ameliorate acne allows most adolescent acne to be managed in the primary care ­setting.

Epidemiology The prevalence of acne in the United States is an estimated 85% among individuals aged 12 to 24 years, 8% among those aged 25 to 34 years, and 3% among those aged 35 to 44 years. The mean ages of onset are 11 years in females and 12 years in males, with peak prevalence rates at 15–17 and 17–19 years, respectively. During adolescence, the prevalence and severity of acne are higher in males than females. During young adulthood, however, acne is three times more common among females than

Acne vulgaris develops within the pilosebaceous unit of the skin. This unit consists of the sebaceous glands surrounding the deep follicular bulb and the infundibulum that connects the sebaceous glands to the epidermis. Acne begins with the formation of a dense, microscopic keratinous plug (i.e., microcomedo) that blocks the flow of sebum to the skin’s surface. The accumulating sebum and keratin obliterate the follicular architecture and eventually form a non-inflammatory comedone on the skin’s surface that is visible to the naked eye. When the surface of the comedone is closed, it appears white and may be missed unless a good light source is utilized and the skin is stretched. When the surface is open, the comedone appears black due to the oxidation of melanin and light refraction from the skin’s surface. Inflammatory acne develops in response to the colonization of the sebum-rich follicle by a gram-positive anaerobe, Propionibacterium acnes (P. acnes). The bacterium secretes a lipase that hydrolyses triglycerides in the sebum to glycerol, which is then used by the ­bacterium as a growth substrate. Other pro-inflammatory mediators secreted by the bacterium cause irritation and rupture of the follicular wall, with extrusion of the comedonal contents into the dermis. The early inflammatory infiltrate seen within the dermis reflects a non-immune, foreign-body response to the keratin, hair, and sebum. However, the presence of P. acnes and its mediators can lead to delayed hypersensitivity, cell-mediated immunity, and complement activation. Up to one-third of inflammatory lesions (i.e., papules, pustules, nodules, and cysts) 97

98

Adolescent Medicine: The Requisites in Pediatrics

lead to scarring, and many cause post-inflammatory hyper- or hypopigmentation. Androgens stimulate secretion of sebum and hyper­ proliferation of keratinocytes within the psilosebaceous unit. The sensitivity of the psilosebaceous unit to circulating androgens, as well as serum androgen levels, contribute to the development of acne. Serum androgen levels are higher in females with than without acne, and both exogenous and endogenous androgens are associated with acne. Hyperandrogenic conditions such as Polycystic Ovary Syndrome (PCOS) are discussed in detail in Chapter 23. External factors, such as oil-based cosmetics, may exacerbate acne but do not cause most cases. Similarly, cleansers may improve the skin’s appearance by removing excess sebum but do not alter sebum production and do not cure acne. Scrubbing may disrupt the skin barrier, foster bacterial colonization, and worsen inflammation. Stress and diet have both been shown to affect the course of acne, but there is no evidence that they cause or cure acne.

Box 15-1  Interviewing the Adolescent

with Acne

General Medical Questions: l

l

l l

l

l l l l

Screening for Psychosocial Impairment: l

l

l

Evaluation

l l

The objectives when evaluating an adolescent with acne are to identify causative or exacerbating factors, define lesion type and severity, determine or adjust the treatment plan, and assess the response to treatment. Although the diagnosis of acne vulgaris is usually straightforward, other conditions do present with acneiform lesions. For example, acne rosacea is a disorder of adults that presents with non-comedonal papular or inflammatory acne associated with vascular dilatation of the central face. Acne fulminans is a disease of adolescent males characterized by the rapid onset of severe inflammatory acne, high fever, leukocytosis, proteinuria, elevated erythrocyte sedimentation rate, and osteolytic lesions. Dermatological consultation should be obtained, and treatment typically includes systemic corticosteroids. Pyoderma faciale, or rosacea fulminans, is acute inflammatory acne in women that follows severe stress and is treated with oral corticosteroids. Chloracne is severe inflammatory acne caused by environmental exposure to halogenated ­hydrocarbons such as dioxin. When interviewing an adolescent with acne, the history should include discussion of the age of onset of the acne, association with pubertal development and menses, response to treatment, family history of acne, psychosocial function, signs or symptoms of hyperandrogenism, and use of medications associated with acne (e.g., corticosteroids, androgens, bromides, iodides, lithium, and phenytoin). Suggested questions that can help guide the interview are shown in Box 15-1.

How much of a problem do you feel your acne has become? What was the age of onset of your acne, and how rapidly did it develop? Which products have you tried to treat the acne? Are you currently using any products to treat acne? If so, which? Do you use other prescription and/or nonprescription medications? Do you use cosmetics or hair greases? What sports do you play? Do you have a history of other medical problems? Is there a family history of severe acne?

l

Are you feeling depressed, nervous, anxious, upset, confused, or scared by your acne? How is the acne affecting your self-esteem and selfconfidence? Is your social life or are other activities being affected by acne? Is your ability to do studies or work being hindered? Are you preoccupied with your acne? Do you think about hurting yourself? Are these thoughts related to your acne?

Questions for Females: l

l

l l

l

When was the first day of your last menstrual period? And the one before that? Are your periods regular? How often? How long do they last? Does your acne worsen before or during your period? Have you noticed excess hair growth on your face or elsewhere that troubles you? Are you sexually active? If so, what methods of birth control do you use?

The physical examination should document the location, type, and severity of acneiform lesions (Table 15-1); other skin findings such as scarring, hyperpigmentation, telangiectasias, hirsutism, or acanthosis nigricans; and signs of virilization in females such as clitoromegaly or alopecia. In a study of adult women with acne, 39% had irregular menses and, of these, 37% had PCOS. The ­diagnosis therefore should be considered and evaluation pursued in adolescent and adult females with acne, irregular menses, and hirsutism. If the physical examination reveals virilization, the patient should also be evaluated for late-onset congenital adrenal hyperplasia (i.e., partial 21-hydroxylase deficiency), as discussed in Chapter 23.



Acne

Box 15-2  Myths vs. Facts about Acne

Table 15-1 Classification of Acne Lesions Type

Noninflammatory

Inflammatory

Name

Description

Closed comedone Firm, slightly (whitehead) elevated, closed orifice Open comedone Flat or raised, open (blackhead) orifice, dark color Papule Erythematous, solid, raised Pustule Firm, raised, erythematous, pus at surface Nodule Firm, indurated, no visible orifice Cyst Large nodule, ± fluctuance, ± abscess

99

Vulgaris

Size (mm) 1–2

1–5 1–5 1–5

5–10 > 10

Management The management of acne begins with patient education about the causes of acne, general skin care, and expected response to treatment (Box 15-2). All adolescents should be taught that the affected skin should be washed gently (i.e., no scrubbing) with a mild, non-comedogenic soap or cleanser. Regardless of the treatment plan, at least 6 to 8 weeks of use is required for existing microcomedones to progress through the comedone stage and resolve. During this time, the acne may appear unchanged or even worse and the tendency is to discontinue treatment. Expecting this lag before improvement occurs may help adolescents adhere during the early treatment months. The type and severity of the acneiform lesions determine the specific medications prescribed (Table 15-2). The classes of drugs used to treat acne and their indications for use are described in Table 15-3.

Myth: Chocolate, greasy foods, fast foods, soft drinks, and other foods cause acne. Fact: There have been no meta-analyses, randomized controlled studies, or well-designed scientific trials following evidence-based guidelines substantiating a link between diet and acne. Myth: Poor hygiene or not washing frequently enough causes acne. Fact: Lack of hygiene has no effect on the presence or severity of acne. Frequent washing with harsh soaps may in fact irritate the skin, exacerbating acne. Myth: Scrubbing the skin and opening comedones helps acne. Fact: Any type of mechanical trauma to the skin may traumatize existing acne lesions, increase inflammation, delay resolution of lesions, and increase the likelihood of scar formation. Myth: Cosmetics, but not hair products, can worsen acne. Fact: Oil-based cosmetics and hair products both can exacerbate acne. Hair pomades are especially problematic and should be avoided. Noncomedogenic, water-based products are less likely to cause problems. Myth: Cigarette smoking has no effect on acne. Fact: Several studies have shown a relationship between acne severity and daily cigarette consumption.

Topical retinoids (i.e., adapalene, tretinoin, and tazarotene) are the mainstay of treatment for comedonal acne (Tables 15-4 and 15-5). They act through nuclear receptors to normalize epidermal proliferation and differentiation, leading to decreased microcomedo formation. Adverse effects such as skin irritation and dryness are least likely with adapalene and most likely with

Table 15-2 Treatment of Acne Vulgaris Acne Type

First-Line Treatment

Alternate Treatment

Maintenance

Comedonal Mild inflammatory

Topical retinoid Benzoyl peroxide  topical antibiotic

Topical azelaic or salicylic acid Topical retinoid or azelaic acid

Same Same

Moderate inflammatory

Oral antibiotic + benzoyl peroxide + topical retinoid

Oral isotetinoin  estrogen/progestin for females

Severe inflammatory

Oral isotretinoin

Oral antibiotic  estrogen/progestin for females  benzoyl peroxide  topical retinoid

Discontinue oral antibiotic and oral isotretinoin after 4–6 months Discontinue oral antibiotic and oral isotretinoin after 4–6 months

Modified from Katsambas AD, Stefanaki C, Cunliffe WJ: Guidelines for treating acne. Clin Dermatol 2004;22:439–444.

100 Adolescent Medicine: The Requisites in Pediatrics

Table 15-3 Topical Agents Used in the Treatment of Acne Name

Formulation

Dose

Tretinoin

Cream: 0.01%, 0.025%, 0.05%, 0.1%, 0.4% Gel: 0.01%, 0.025%, 0.04%, 0.1% Solution: 0.05%, 0.1%, 0.2% Lotion: 0.1% Gel microsphere: 0.1% Polymer cream: 0.025% Gel, solution, cream, swab: 0.1% 0.05%, 0.1% gel Cream: 20% cream Gel: 15% Topical cream: 2.5%, 5%, 10% Topical gel/jelly: 2.5%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% Topical liquid: 2.5%, 5%, 10% Topical lotion: 2.5%, 4%, 5%, 5.5%, 8%, 10% Topical pad: 3%, 6%, 9%, 10% Topical soap: 5%, 10% Solution, gel, lotion, foam, pad: 1%

Daily, preferably at bedtime

Adapalene Tazarotene Azelaic acid Benzoyl peroxide

Clindamycin Erythromycin

Solution: 1%, 2% Ointment: 2% Gel: 2%, 4% Erythromycin 3% + benzoyl peroxide 5% gel Erythromycin 4.0% + tretinoin 0.025% gel Erythromycin 2% + isotretinoin 0.5% gel Clindamycin 1% + benzoyl peroxide 5% gel Clindamycin 1% + tretinoin 0.025% gel

Daily, preferably at bedtime Daily Twice daily Apply daily for the first 3 days, then once or twice daily

Twice-daily solution, gel or lotion Once-daily foam, pad Twice daily

Once or twice daily Daily, preferably at bedtime Daily, preferably at bedtime Once or twice daily Daily, preferably at bedtime

tazarotene. Tretinoin is the most commonly prescribed topical ­retinoid, in part because of its availability in multiple formulations (i.e., cream, gel, and solution) and potencies (0.025% to 0.1%). Although creams tend to cause less irritation than gels or solutions, the microencapsulated 0.1% gel appears to be fairly well tolerated. Topical salicylic (1–5%) or azelaic acid is a useful alternative or adjunct to topical retinoids for the treat-

ment of non-inflammatory acne. Both of these topical preparations have comedolytic and antimicrobial effects without the photosensitization typical of the topical ­retinoids. Topical benzoyl peroxide is considered first-line treatment for mild inflammatory, or papular, acne (Tables 15-4 and 15-5). Common side effects resemble those of the topical retinoids, with skin irritation, dryness, and sun

Table 15-4 Spectrum of Efficacy of Topical Agents in Acne Therapy Agent

Tretinoin Isotretinoin Adapalene Tazarotene Azelaic acid Benzoyl peroxide Clindamycin Erythromycin Tetracycline

Keratolytic/ Anticomedogenic

Sebosuppressive

Antimicrobial

Anti-inflammatory

+++ +++ +++ +++ ++ + + + +

− − − − − − − − −

+ + + + ++ +++ +++ +++ +++

− + ++ − + − + + +

−, none; +, weak; ++, moderate; +++, strong. Source: Krautheim A, Gollnick HP: Acne:Topical treatment. Clin Dermatol 2004;22:398–407.

Acne 101



Table 15-5 Adverse Drug Reactions of Topical Agents in Acne Therapy Agent

Erythema

Scaling

Burning

Acne Flare

++++

++++

+++

+++

−

+++

−

Isotretinoin

+++

+++

++

++

−

+

−

Adapalene

++

++

++

++

−

−

−

Tazarotene

++

++

++

++

−

−

−

Azelaic acid

++

++

++++

−

−

−

−

Benzoyl peroxide

+++

+++

++

++

−

−

Topical antibiotic

+

+

−

−

++++

+ (Tetracycline)

Tretinoin

Bacterial Resistance Photosensitivity

Other

Bleaches hair and clothes; rarely, contact sensitivity Rarely, contact sensitivity

−, none; +, weak; ++, moderate; +++, strong; ++++, very strong. Source: Krautheim A, Gollnick HP: Acne:Topical treatment. Clin Dermatol 2004;22:398–407.

sensitivity. Benzoyl peroxide is more effective when used in combination with topical antibiotics and/or topical retinoids than when used alone. It is available in gel, lotion, solution, and cream form and in potencies of 2.5%, 5%, and 10%. Patients should be told that it may bleach clothing and bed linens. Topical antibiotics are indicated for the treatment of mild to moderate inflammatory acne and are more effective when used in combination with benzoyl peroxide or retinoids than when used alone. The combination use is thought to enhance skin absorption and decrease the development of bacterial resistance. Topical clindamycin and erythromycin are preferred over topical tetracycline because of the yellow staining that can occur with the latter. Systemic absorption of topical antibiotics

is minimal, and skin irritation is less than with the other topical preparations. Oral antibiotics (Table 15-6) are indicated for moderate inflammatory acne with scarring, hyperpigmentation, widespread involvement, and/or resistance to topical antibiotic treatment. The usual course of treatment is 4– 6 months, in combination with a topical retinoid and/or benzoyl peroxide. Once the inflammation is controlled, the antibiotic should be tapered and discontinued. By 2001, more than half of the strains of P. acnes in the United Kingdom were found to have antibiotic resistance. Antibiotic resistance is also fast becoming a global ­problem. Among antibiotics, resistance to erythromycin is greatest, followed by tetracycline, doxycycline, and minocycline. Often, P. acnes resistant to topical erythromycin is cross-

Table 15-6 Oral Antibiotics Used in the Treatment of Acne Antibiotic

Name

Dose

Drawbacks

Tetracyclines

Tetracycline

250–500 mg twice daily

Doxycycline

50–100 mg twice daily

Minocycline

50–100 mg twice daily 100 mg once daily (slow release)

Erythomycin

500 mg twice daily

Azithromycycin

250 mg three times a week

Gastrointestinal upset Vaginal candidiasis Need to take on empty stomach Gastrointestinal upset Photosensitivity Vertigo Hyperpigmentation of skin and oral mucosa Expensive Uncommonly, significant systemic adverse effects Gastrointestinal upset Vaginal candidiasis Emergence of resistance of P. acnes is common Gastrointestinal upset

Macrolides

Modified from Katsambas A, Papakonstantinou A: Acne: Systemic treatment. Clin Dermatol 2004;22:412–8.

102 Adolescent Medicine: The Requisites in Pediatrics

resistant to clindamycin, and erythromycin-resistant P. acnes have also been found in a significant number of patients never treated with erythromycin. To date, there has been no reported resistance to benzoyl peroxide or azelaic acid. Recommendations have been made to help decrease existing resistant P. acnes and to counteract selection of newly resistant P. acnes. Antibiotics should be avoided if non-antibiotic agents, such as benzoyl peroxide or retinoids, can be used and are effective. Topical or oral antibiotics should always be used in combination with benzoyl peroxide. Oral or topical antibiotics should be discontinued once inflammatory lesions subside, and treatment should be continued with non-antibiotic topical medications. Antibiotics should not be prescribed for longer than 6 months, and the same antibiotic should be used if retreatment is required. A trial period of a minimum of 2 months should be allowed before changing antibiotics due to poor therapeutic response. To decrease development of resistance, use of oral and topical antibiotics with chemically dissimilar properties should be avoided. Short, intervening courses of benzoyl peroxide may help reduce or eliminate resistant bacteria. Oral contraceptives are effective in the treatment of acne in females both with elevated and normal androgen levels (Table 15-7). An estrogen combined with a lowandrogenic progestin should be prescribed for a trial of at least 4–6 months. A triphasic pill ­containing ethinyl estradiol and norgestimate has been shown to decrease lesions nearly 30% more than placebo and has been approved for use in the treatment of female acne. Although oral contra-

ceptives are considered first-line therapy for females with PCOS, control of the acne and hirsutism often requires metformin, as discussed in Chapter 23. Oral isotretinoin is used for the treatment of severe inflammatory acne unresponsive to the measures described previously. It decreases sebum secretion for up to 1 year after completion of therapy, with a resultant decline in P. acnes, comedogenesis, and inflammation. Adverse effects, including spontaneous abortions and severe congenital malformations, are common. Physicians prescribing isotretinoin and pharmacies dispensing it must be registered with the U.S. Food and Drug Administration (FDA), and physicians must document their expertise with the drug and familiarity with its risks. The FDA requires that all sexually active female patients have two negative pregnancy tests before treatment, use two contraceptive methods during treatment, have monthly pregnancy tests during treatment, and be enrolled in an electronic database of the FDA. In addition to the teratogenicity, all patients experience dose-­dependent skin irritation, desquamation, cheilitis, and photosensitivity. Liver function studies, lipids, and CBC should be monitored monthly for hepatotoxicity, hypertriglyceridemia, and bone marrow suppression. Patients also may experience arthralgias, myalgias, and decreased night vision. Although there are reports of depression and suicidal behavior with isotretinoin use and the FDA recommends that patients be monitored closely for depressive ­symptoms, the ­current literature is inconclusive. Isotretinoin is begun at 0.5 mg/kg daily and increased to a maximum of 2 mg/kg daily for very severe acne.

Table 15-7 Oral Hormonal Treatment in Acne Agent

Indication

Dose

Drawbacks

Oral contraceptive pills (i.e., Estrostep, Orthotricyclen)

Moderate to severe acne, PCOS

1 pill daily

Spironolactone

Acne with hirsutism

25–100 mg twice daily

Flutamide

Acne with hirsutism

250 mg twice daily

Prednisone Dexamethasone Leuprolide

Late-onset CAH Late-onset CAH Acne with hirsutism

2.5–5 mg daily 0.125–0.5 mg daily Per gynecologist or endocrinologist

Vascular thrombosis Melasma Weight gain Menstrual irregularities Breast tenderness Electrolyte abnormalities Contraindicated in pregnancy Hepatotoxicity, may be fatal Menstrual abnormalities if not combined with OCPs Contraindicated in pregnancy Adrenal suppression Adrenal suppression Hypoestrogenism Bone loss Headaches Emotional lability Hot flashes

PCOS, polycystic ovary syndrome; OCP, oral contraceptive drug; CAH, congenital adrenal hyperplasia. Modified from Katsambas A, Papakonstantinou A: Acne: Systemic treatment. Clin Dermatol 2004;22: 412–418.

Acne 103



The daily dose should be administered in 2 divided doses with food for a total cumulative dose of 120–150 mg/kg over 20 weeks. More than 80% of patients achieve remission, but more than 60% also require ongoing use of topical or oral antibiotics. Most relapses occur in patients with truncal acne and those who received less than the ­recommended total dose.

 l

l

l

l

l

l

l

l

l

l

Major Points

b

Acne has significant negative effects on emotional well-being and social functioning. It is important to perform a careful history and physical examination in all patients with acne and for the physician to show empathy for the patient’s distress due to acne. Patients with acne should be taught about gentle skin cleansing, be shown appropriate application techniques for topical therapies, have acne myths dispelled, and be helped to have realistic expectations of therapy. Knowledge of the pathophysiology of acne should guide individualized treatment. Acne is the result of hyperproliferation, abnormal ­differentiation, and desquamation of follicular keratinocytes; sebaceous hyperplasia with increased sebum production; follicular proliferation of P. acnes; and inflammation. Topical retinoids are the initial therapy for ­comedonal acne. Topical benzoyl peroxide and/or topical antibiotics may be added for papular and inflammatory acne. The combination of topical retinoids with antimicrobial therapy is appropriate for mild to moderate inflammatory acne. For more severe inflammatory acne, oral antibiotics for 4–6 months should be combined with topical retinoids. Hormonal therapy with an estrogen and low­androgenic progestin is effective for the ­treatment of acne in females both with and without ­hyperandrogenism. Prior to hormonal treatment, females with signs and symptoms of ­hyperandrogenism should be ­evaluated for PCOS. Those with virilization should also be ­evaluated for late-onset congenital adrenal ­hyperplasia. Oral isotretinoin therapy is appropriate for those with severe inflammatory acne unresponsive to other therapies. Side effects are significant, and the treatment should be prescribed and monitored by a physician experienced with the drug.

Bibliography Dreno B, Poli F: Epidemiology of acne. Dermatology 2003;206: 7–10. Gollnick H: Current concepts of the pathogenesis of acne: Implications for drug treatment. Drugs 2003;63:1579–1596. Gollnick H, Cunliffe W, Berson D, et al.: Management of acne: A report from a Global Alliance to Improve Outcomes in Acne. J Am Acad Dermatol 2003;49:S1–S37. Gupta MA, Gupta AK: The psychological comorbidity in acne. Clin Dermatol 2001;19:360–363. Katsambas A, Papakonstantinou A: Acne: Systemic treatment. Clin Dermatol 2004;22:412–418. Katsambas AD, Stefanaki C, Cunliffe WJ: Guidelines for treating acne. Clin Dermatol 2004;22:439–444. Krautheim A, Gollnick HP: Acne: Topical treatment. Clin Dermatol 2004;22:398–407. Krowchuk DP, Lucky AW: Managing adolescent acne. Adolesc Med 2001;12:355–374. Lee DJ, Van Dyke GS, Kim J: Update on pathogenesis and treatment of acne. Curr Opin Pediatr 2003;15:405–410. Lucky AW, Biro FM, Simbartl LA, et al.: Predictors of severity of acne vulgaris in young adolescent girls: Results of a five-year longitudinal study. J Pediatr 1997;130:30–39. Swanson JK: Antibiotic resistance of propionibacterium acnes in acne vulgaris. Dermatology Nursing 2003;15:359–362. Thiboutot D: Acne: Hormonal concepts and therapy. Clin Dermatol 2004;22:419–428. Thiboutot DM: Endocrinological evaluation and hormonal therapy for women with difficult acne. J Eur Acad Dermatol Venereol 2001;15(Suppl 3):57–61. Witkowski JA, Parish LC: The assessment of acne: An evaluation of grading and lesion counting in the measurement of acne. Clin Dermatol 2004;22:394–397. Wolf R, Matz H, Orion E: Acne and diet. Clin Dermatol 2004;22:387–393. Zouboulis CC, Eady A, Philpott M, et al.: What is the pathogenesis of acne? Exp Dermatol 2005;14:143–152.

16

C hAp t e r

Introduction Definitions and Diagnostic Criteria Primary vs. Secondary Headache Migraine Childhood Periodic Syndromes Migraine Variants

Epidemiology Pathophysiology Evaluation Management General Measures Abortive Therapy Prophylactic Therapy

Outcome

Introduction Headache and migraine are common in children and adolescents. Up to 75% of children report having had at least one significant headache by age 15 years, and 28% meet the diagnostic criteria for childhood migraine established by the International Headache Society (IHS). This chapter reviews the classification, epidemiology, pathophysiology, evaluation, management, and outcome of headache disorders during adolescence. It focuses on the differentiation of primary from secondary headaches and on the management of migraine and tension-type headaches.

Definitions and Diagnostic Criteria Primary vs. Secondary Headache Headaches are broadly categorized as primary or secondary. Primary headaches have no identifiable underly104

Headaches Andrew D. Hershey, MD, PhD Marielle A. Kabbouche, MD

ing cause. Diagnoses in this category include migraine and tension-type headaches. Secondary headaches are directly attributable to specific underlying conditions such as infection, tumor, bleed, trauma, toxin, and vasculitis. As noted below, a major goal when evaluating a patient with headache is to identify underlying, treatable conditions.

Migraine The diagnostic criteria for migraine without and with aura are outlined in Box 16-1. Migraine without aura, previously referred to as common migraine, consists of prodromal symptoms (e.g., change in personality, appetite, thirst) that occur several hours before the headache. Migraine with typical aura, previously referred to as classical migraine, involves visual, sensory, or speech symptoms that develop gradually and resolve completely within 1 hour. If the aura includes motor weakness, the migraine is termed either familial hemiplegic migraine or sporadic hemiplegic migraine. The former follows an autosomal dominant pattern of inheritance and involves mutations in three genes responsible for transmembrane sodium, potassium, and/or calcium channels. Patients with sporadic hemiplegic migraine have auras involving motor weakness but do not have first- or second-degree relatives with the syndrome. Basilar-type migraine usually begins before adolescence and is characterized by occipital headaches associated with cerebellar-type symptoms in the absence of motor weakness. The symptoms may include vertigo, tinnitus, decreased hearing, ataxia, vomiting, dysarthria, simultaneous temporal- and nasal-field visual symptoms, bilateral paresthesias, and decreased mental status. Migraine with prolonged aura is defined as a migraine with typical or atypical aura in which a focal neurological finding persists 1 hour to 1 week beyond resolution of the headache, with no evidence of infarction

Headaches 105



Box 16-1  Criteria for the Diagnosis

of Migraine

Migraine without Aura l l

l

l

l

≥ 5 headache attacks that meet the criteria below. Headache lasts 4–72 hours in patients ≥ 15 years and 1–72 hours in patients < 15 years of age. Headache has ≥ 2 of the following characteristics: unilateral; interferes with daily activities; aggravated by routine physical activity. Headache is accompanied by ≥ 1 of the following characteristics: nausea and/or vomiting; photophobia and/or phonophobia. Headache is not attributable to another disorder.

Migraine with Aura l l

l

l l

≥ 2 headache attacks meeting the criteria below. Aura consists of visual symptoms, sensory symptoms, and/or dysphasic speech; is fully reversible; and does not include motor weakness. Aura has ≥ 2 of the following characteristics: l Homonymous visual symptoms and/or unilateral sensory symptoms. l At least one aura symptom develops gradually over ≥ 5 minutes and/or different aura symptoms occur in succession over ≥ 5 minutes. Each symptom lasts ≥ 5 and ≤ 60 minutes. Not attributed to another disorder.

on neuroimaging. Persistent aura is defined as a focal neurological finding persisting more than 1 week beyond resolution of the headache, with no evidence of infarction on neuroimaging. Migrainous infarction is defined as evidence of infarction on neuroimaging in a patient who meets criteria for migraine with prolonged aura.

Childhood Periodic Syndromes In the 2004 revision of the IHS criteria for the diagnosis of migraine, cyclical vomiting, abdominal migraine, and benign paroxysmal vertigo were categorized as childhood periodic syndromes that are harbingers of future migraine but are not defined as migraine disorders. Cyclical vomiting syndrome consists of repeated episodes of nausea and vomiting without headache that last hours to days. It usually begins in early childhood and ends by puberty. Abdominal migraine consists of recurrent vague abdominal pain associated with at least two of the following symptoms: anorexia, nausea, vomiting, and/or pallor. Benign paroxysmal vertigo of childhood consists of brief episodes (i.e., minutes) of recurrent dizziness and unsteadiness, often associated with nausea, pallor, photophobia, and/or phonophobia. The episodes may cluster over hours or days but tend to resolve after several attacks.

Migraine Variants Headache with preceding or coincident visual hallucinations or delusions occurs more commonly in children and adolescents than adults. The cause is unknown, but probably reflects ischemia related to the migraine. Migraine associated with disorientation and agitation persisting beyond the headache is termed confusional migraine. Hemi­ syndrome migraine involves hemiparesis, hemisensory deficits, visual field cuts, and/or language deficits that may begin up to 60 minutes before the headache and last several days afterward. Menstrual migraine is a migraine headache that occurs close to the onset of menses and is thought to be related to the premenstrual decline in estrogen and progesterone levels. Ophthalmoplegic migraine is headache of at least 1-week duration with the onset of a third or sixth cranial nerve palsy up to 4 days after onset of the headache. Evidence of inflammation on magnetic resonance imaging (MRI) led to the 2004 reclassification of ophthalmoplegic migraine as a cranial neuralgia.

Epidemiology Large-scale studies of headache performed over the past 50 years demonstrate a steady increase in the prevalence of migraine from early childhood to late adolescence, with a shift from male to female predominance. One study of more than 2000 children and adolescents revealed a migraine prevalence of 28% in the 15- to 19-year-old group. Characteristics of this group included a strong family history of migraine in 81%, aura in 9%, and association with menses in nearly 25% of the females. Tension-type headaches have been less well studied than migraines, and prevalence estimates in children and adolescents range from 1% to nearly 75%. Of children and adolescents with migraine, more than half meet criteria for migraine without aura. Up to 30% have migraine with typical aura, and up to 19% have basilar migraine. Familial hemiplegic migraine and sporadic hemiplegic migraine are rare.

Pathophysiology The pathophysiology of migraine remains undefined. Although three genes have been identified for familial hemiplegic migraine and some of these genes may contribute to familial migraine with aura, no genes have been linked to migraine without aura. Neuroimaging studies of patients with migraine have demonstrated brainstem abnormalities in the region of the trigeminal nucleus, supporting theories that the trigeminal neurovascular system is involved in migraine pathophysiology. The cause of tension-type headache, like migraine, remains unknown. The “continuum model” postulates

106 Adolescent Medicine: The Requisites in Pediatrics

that tension-type and migraine headaches constitute one pathophysiological disorder of varying severity. The “spectrum model” postulates they are separate entities, with migraine representing a full-spectrum headache and tension-type representing a mild to moderate pain disorder. Tension-type headaches may involve muscle contraction that stimulates a feedback loop or involves central sensitization that builds pain severity.

inflammatory drugs (NSAIDs), acetaminophen, and combination analgesics apply to patients with either tension-type or migraine headaches. The other abortive ­medications and the prophylactic medications described below are intended for patients with migraine but are often tried in patients with severe tension-type headaches that are otherwise unresponsive. Table 16-1 summarizes the medications commonly used for the management of primary headache disorders in adolescents.

Evaluation The first goal of evaluation is to determine whether the headache is primary or secondary. The history should include headache duration, severity, quality, location, and radiation; prodromal and associated symptoms; precipitating, exacerbating, and relieving factors; and psychosocial effects. Family history should be reviewed for migraine, other headache, cerebrovascular disease, and other intracranial conditions. A thorough neurological examination is the most sensitive indicator of a need for further assessment, and neuroimaging is the most sensitive tool for the detection of a treatable cause of the headache.

Management The management of primary headache disorders has not been studied as thoroughly in children and adolescents as in adults. Consequently, most published recommendations are based on clinical trials in adults and clinical experience in children and adolescents. The general measures described below and the use of nonsteroidal anti-

General Measures Factors identified on history that precipitate, exacerbate, or relieve recurrent headaches should be discussed in detail. The adolescent should be asked to keep a headache log that documents timing, severity, and response to intervention. Even if the history fails to identify factors, adolescents and parents should be asked to pay particular attention over the subsequent weeks to potential associations with stress, menses, sleep, and diet. Adole­ scents with mild or moderate tension-type headaches that do not interfere with function should be encouraged to remain in school or continue their activities as tolerated. Those with more severe headaches should be instructed to rest in a quiet, dark room and to begin abortive treatment early. Once the adolescent begins to use abortive medications, care should be taken to avoid overuse. In addition to drug-specific side effects, the likelihood of rebound headache increases with sustained overuse. If rebound is suspected, the medication should be tapered and the adolescent should be observed for several weeks before it is reinstituted.

Table 16-1  Medications for the Abortive Treatment of Headache in Adolescents Drug Class

Drug

Dosage1

NSAID

Ibuprofen Naproxen Ketoralac

5–10 mg/kg PO q 2–4 hours, not to exceed 50 mg/kg daily 250–500 mg PO every 8–12 hours, not to exceed 3 doses daily 0.5–1 mg/kg IV or 0.25 mg/kg PO every 6 hours, not to exceed 1 mg/kg daily 10–20 mg/kg q 2–4 hours, not to exceed 1000 mg per dose or 3 doses daily

Acetaminophen Combination Triptan Anti-emetic

Ergot alkaloid

Midrin Sumatriptan Zolmitriptan Promethazine Dimenhydrinate Metoclopramide DHE (following metoclopramide)

2 capsules PO, then 1 capsule PRN every hour, not to exceed 4 capsules daily or 8 capsules weekly 25–100 mg PO or 5–20 mg IN; may repeat once in 2 hours 2.5–5 mg PO; may repeat once in 2 hours 0.2–0.5 mg/kg PO, IM, PR every 8–12 hours 1.25 mg/kg PO, IM every 4–6 hours 0.13–0.15 mg/kg, not to exceed10 mg, given IV over 15 minutes DHE 0.15–0.2 mg IV, given 30 minutes after metoclopramide 5–10 mg PO. Can increase by 0.05 mg/dose as tolerated and repeat every 6 hours until 1 dose beyond headache cessation or to a maximum of 16 doses. DHE (following DHE 0.5–1 mg IV, given 30 minutes after prochlorperazine 0.13–0.15 mg/kg IV and repeated every prochlorperazine) 8 hours until 1 dose beyond headache cessation. Change to another anti-emetic if nausea persists after 3 doses.

PO, orally; IM, intramuscularly; IV, intravenously; PR, rectally; IN, intranasally; PRN, as needed.

1

Headaches 107



Biofeedback, relaxation training, and stress management training have all been shown to reduce headache frequency and severity in children. Limitations to their use are the availability of trained counselors, health insurance coverage, and patient adherence to learned techniques.

Abortive Therapy NSAIDs are considered first-line therapy for the acute management of headache and migraine. A crossover trial comparing ibuprofen 10 mg/kg, acetaminophen 15 mg/kg, and placebo for the acute treatment of migraine in patients aged 4–16 years showed that pain reduction was three and two times more likely with ibuprofen and acetaminophen than placebo, respectively, and pain resolution at 2 hours was two times more likely with ibuprofen than acetaminophen. Combination analgesics, such as Midrin, are commonly used in adolescents who do not respond to single analgesics. Midrin includes a mild sympathomimetic agent, a mild sedative, and acetaminophen. Triptans represent an important advance in early, abortive therapy for migraine. All are serotonin agonists that increase vasoconstriction and therefore are contraindicated in patients with hemiplegic or basilar artery migraine. Seven triptans have been approved by the U.S. Food and Drug Administration (FDA) for use in adults with migraine. Although none is approved for pediatric use, placebo-controlled trials have demonstrated the effectiveness of oral and intranasal sumatriptan and oral zolmitriptan in adolescents with migraine. Response rates within 2 hours ranged from 58–88%, and the rates of adverse effects were lower than those reported in adults. Subcutaneous administration, as in adults, increased the risk of adverse effects and, in contrast to adults, has not been shown to be more effective than oral or intranasal administration. Adolescents with episodic headaches unresponsive to oral analgesics or the triptans usually require treatment in the emergency department or hospital with parenteral NSAIDs (i.e., ketoralac); dopamine antagonists (e.g., phenothiazines, metoclopramide); dihydroergotamine (DHE); or anti-epileptic medications (e.g., sodium valproate). Dopamine antagonists such as prochlorperazine, promethazine, and metoclopramide initially were used only in patients who had nausea and vomiting associated with migraine. Subsequent studies, however, demonstrated their effectiveness in aborting pain when given parenterally, along with intravenous fluid loading. In an emergency department study of intravenous prochlorperazine, 50% of adolescents with migraine were pain-free and 75% had improved at 1 hour. Another trial demonstrated headache improvement in 82% of subjects receiving ­prochlorperazine compared with 42% receiving metoclopramide and 29% receiving placebo. Although prochlor­

perazine has been used in most studies, promethazine carries a lower risk of extrapyramidal side effects and therefore has become the phenothiazine of choice for the treatment of migraine in children and adolescents. Parenteral ketorolac is often used in the emergency department as monotherapy for migraine or in combination with other drugs. Studies report improvement in 55% of subjects when ketoralac is used alone and in 93% when it is used with prochlorperazine. The 30% rate of headache recurrence within 24 hours of the ketoralac was thought to represent rebound in patients who had been overusing other NSAIDs prior to presenting to the emergency department. Ergot alkaloids were first recognized as useful in the abortive treatment of migraine nearly 100 years ago. Of note, all ergot alkaloids are contraindicated in patients with familial hemiplegic migraine, basilar migraine, migraine with aura, and pregnancy. Ergotamine tartrate administered orally, sublingually, or rectally as monotherapy or combined therapy was commonly prescribed in adults until the early 1990s, when controlled trials showed no evidence of efficacy and high rates of nausea, vomiting, vasoconstriction, physical dependence, and rebound headache. DHE causes less arterial and more venous constriction than does ergotamine tartrate, is better tolerated, and has not been associated with dependence or rebound. A 1994 study demonstrated that 80% of children with refractory migraine improved following intravenous DHE and oral metoclopramide, and had few side effects. Therefore, two DHE protocols have evolved for children and adolescents with migraine without aura that is refractory to other abortive regimens. As outlined in Table 16-1, both regimens call for premedication with anti-emetics to control gastrointestinal side effects. The first regimen incorporates more frequent administration at lower doses than the second regimen. The advantage of the first is a lower likelihood of side effects. The advantage of the second is a higher likelihood of rapid response. Sodium valproate is less effective at inducing complete remission at 24 hours than DHE (60% vs. 90% of subjects), but it provides an alternative for inpatient abortive therapy when DHE is contraindicated or ineffective.

Prophylactic Therapy The goal of prophylaxis is to reduce headache frequency and severity in patients with at least four disabling headaches monthly. Its success depends on patient and parent understanding of its purpose, the time required for titration toward an optimal dose, and the importance of dose tapering when the medication is to be discontinued. None of the medications commonly used for headache prophylaxis have been approved by the FDA for this use in children. Furthermore, the 2004 Practice Parameter of

108 Adolescent Medicine: The Requisites in Pediatrics

the American Academy of Neurology concludes that there is insufficient evidence to recommend the use of any specific medication for migraine prophylaxis in children and adolescents, except perhaps one calcium channel blocker (i.e., flunarizine) that is not available in the United States. In the absence of guidelines, decisions about prophylactic therapy in adolescents are based upon the extensive literature in adults and the few studies in older children and adolescents that demonstrate probable effectiveness. The medications used most commonly for prophylaxis in adolescents are amitriptyline or nortriptyline, propranolol or atenolol, valproate, and topiramate (Table 16-2). Propranolol and other beta blockers have a long history of use for migraine prophylaxis. Although studies in children have yielded conflicting results, studies in adults have demonstrated improvement in 60–80% of subjects. Side effects (e.g., fatigue, depressive symptoms, bradycardia, orthostatic hypotension) are common, and beta blockers should be avoided in patients with asthma, diabetes mellitus, and depressive disorders. Tricyclic antidepressants have been used since the 1970s for the prevention of migraine headache in children and adults. Amitriptyline is the most widely used and best-studied drug in the antidepressant class. However, studies of its effectiveness for migraine prophylaxis in children have not been placebo controlled, and most have been open-label. Headache frequency and severity are reported to decrease in 50–80% of children with titration over 8–10 weeks. Side effects include anticholinergic symptoms, weight gain, and arrhythmia at higher doses. Valproic acid and divalproex sodium (valproic acid plus sodium valproate) are oral medications approved in adults for migraine prophylaxis. Studies of divalproex sodium have demonstrated that 76% of subjects aged 7–16 years experience at least a 50% reduction in headache frequency and significant improvements in headache severity. Side effects include weight gain, fatigue, lightheadedness, tremor, teratogenicity, and hepatotoxicity.

Although the optimal serum concentration for migraine has not been established, a reasonable goal is 50–100 mg/ dl. Drug levels and liver function tests should be monitored every 2–3 months in patients on valproate. Topiramate was shown to be more effective than placebo in a large-scale, open-label study but reached only borderline significance ( p = 0.06) in a double-blind ­randomized trial. The trend toward significance and the wide variation in placebo response has led many clinicians to recommend its use in older children and adolescents. To achieve an effective daily dose and minimize side effects such as fatigue and cognitive slowing, topiramate should be started at a low dose of 25 mg daily and increased slowly over an 8- to 10-week period. Cyproheptadine has antihistaminic, antiserotonergic, anticholinergic, and calcium channel blocking properties. Evidence of its effectiveness for migraine prophylaxis is based on a few small, retrospective, uncontrolled studies. In addition, side effects (i.e., appetite stimulation, weight gain, and fatigue) are common and poorly tolerated during adolescence.

Outcome Headache, regardless of type or cause, can have a significant impact on function and quality of life. National surveys in the United States suggest that migraine alone accounts for 3 million missed work days monthly among adults and more than 300,000 missed school days monthly among children. Quality of life measures are lower in adults with migraine than adults with hypertension, diabetes mellitus, or heart disease, and lower in children with migraine than children with rheumatological, oncological, or cardiac disease. Several tools have been developed to assess outcome in adults and children with migraine. In adults, the Migraine Disability Assessment (MIDAS) measures headache-related disability at work, home, and socially over the preceding 3 months. It is a clinically useful tool that has been

Table 16-2  Medications for the Prophylactic Treatment of Headache in Adolescents Drug Class

Drug

Dosage1

Tricyclic antidepressant

Amitriptyline or nortriptyline

Beta blocker

Propranolol Atenolol Valproate Topiramate

Begin 10 mg PO at HS, increase by 0.25 mg/kg/day every 2 weeks to a maximum of 50 mg PO daily Begin 10–20 mg PO TID, increase as tolerated to a maximum of 320 mg PO daily Begin 50 mg PO daily, increase as tolerated to a maximum of 150 mg PO daily Begin 250 mg PO BID, increase as tolerated to a maximum of 1000 mg PO daily Begin 25 mg PO daily, increase as tolerated over 8–10 weeks to a maximum of 100 mg PO BID 0.2–0.4 mg/kg PO daily

Anti-epileptic

Antiserotonergic

Cyproheptadine

PO, orally; HS, at bedtime; BID, twice daily.

1

Headaches 109



incorporated into the Stratified Care Model for the management of adult migraine. A pediatric version incorporates questions about school, home, and social function and increasingly is used to assess treatment strategies. Although disability with migraine can be high, the overall prognosis for children and adolescents with migraine is good. Long-term follow-up studies suggest that migraine frequency decreases in at least half of patients, severity decreases in a third, and less than 15% of those with childhood onset require adult prophylaxis. Studies exploring the risk of ischemic stroke in adults with migraine yield relatively low rates, ranging from 0.8–19 per 100,000 per year. In a study of young adults with acute infarction, migraine accounted for 14%. Of all adults with ischemic strokes, migraine accounted for less than 1%. A 2004 meta-analysis of eight studies revealed that the relative risk of ischemic stroke was 2.9 for adults who had migraine with aura and 1.6 for adults who had migraine without aura.



Major Points

b

The major goal of evaluation is to determine whether the headache is primary or secondary. A thorough neurological examination is the most sensitive indicator of a need for further assessment, and neuroimaging is the most sensitive tool for the detection of a treatable cause of the headache. l Adolescents with mild or moderate tension-type headaches that do not interfere with function should be encouraged to remain in school or continue their activities as tolerated. Those with more severe headaches should be instructed to rest in a quiet, dark room and to begin abortive treatment early. l Once the adolescent begins to use abortive medications, care should be taken to avoid overuse. If rebound is suspected, the medication should be tapered and the adolescent should be observed for several weeks before it is reinstituted. l NSAIDs and probably acetaminophen are effective abortive therapy for headaches and should be considered first-line medications for home use. l Triptans have not been approved by the FDA for use in children and adolescents but appear to be effective when administered orally and intranasally. l Inpatient abortive therapy includes intravenous ketoralac, DHE, and sodium valproate. Although not approved for pediatric use, all appear effective in halting or decreasing the headache and associated symptoms. l Prophylactic therapy should be reserved for adolescents with at least four headaches monthly that interfere with normal function. Although not approved for pediatric use, tricyclic antidepressants, beta blockers, and antiepileptic medications appear effective in preventing or decreasing recurrent headache. l

Bibliography Headache Classification Subcommittee of the International Headache Society: The International Classification of Headache Disorders. Cephalagia 2004;24(1 Suppl):1–160. Hershey AD, Winner P, Kabbouche MA, et al.: Use of the ICHDII criteria in the diagnosis of pediatric migraine. Headache 2005;45:1288–1297. Jensen R: Pathophysiological mechanisms of tension-type headache: A review of epidemiological and experimental studies. Cephalalgia 1999;19:602–621. Kabbouche MA, Linder SL: Acute treatment of pediatric headache in the emergency department and inpatient settings. Pediatr Ann 2005;34:466–471. Lewis DW, Ashwal S, Dahl G, et al.: Practice parameter: Evalu­ ation of children and adolescents with recurrent headaches: Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Practice Committee of the Child Neurology Society. Neurology 2002;59:490–498. Lewis D, Ashwal S, Hershey A, et al.: Practice parameter: Pharmacological treatment of migraine headache in children and adolescents: Report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology 2004;63:2215–2224. Linder SL: Understanding the comprehensive pediatric head­ ache examination. Pediatr Ann 2005;34:442–446. Montagna P: The physiopathology of migraine: The contribution of genetics. Neurol Sci 2004;25(Suppl 3):S93–S96. Powers SW, Hershey AD: Biofeedback for childhood migraine. In Maria BL (ed): Current Management in Child Neurology, 2nd ed. Hamilton, Ontario, BC Decker, 2002, pp. 83–85.

17

C h A p t e r

Introduction Definitions Epidemiology Pathophysiology Sleep Physiology Environmental Factors Affecting Sleep Effects of Inadequate Sleep

Evaluation and Management Psychophysiologic Insomnia (PI) Delayed Sleep Phase Syndrome (DSPS) Obstructive Sleep Apnea (OSA) Restless Legs Syndrome (RLS) and Periodic Limb Movement Disorder (PLMD) Narcolepsy

Introduction Sleep is a complex process influenced by both biological and behavioral factors. Historically, it was thought that teenagers had volitional control over their habitually late bedtimes and resultant sleepiness. Recent evidence, however, highlights the central role of biology in the adolescent sleep/wake cycle and the contributing effects of sociocultural factors such as homework, afterschool employment, delayed curfew, and in-bedroom television and computer use. The interaction between the biological and sociocultural determinants of sleep results in a developmental vulnerability for sleepiness during the teenage years. In addition, the prevalence of certain health conditions during adolescence, such as obesity, increases the risk for clinically significant sleep disorders. The goals of this chapter are to review the physiology of sleep, the impact of inadequate sleep, the evaluation of fatigue, and the management of sleep disorders during adolescence. 110

Fatigue and Sleep Disorders Kelly C. Byars, PsyD, CBSM Raouf S. Amin, MD, ABSM

Definitions Delayed sleep phase syndrome (DSPS): Asynchrony between the internal circadian pacemaker and external time that manifests as difficulty falling asleep at bedtime and awakening in the morning. Dyssomnias: Sleep disorders that cause either insomnia or daytime sleepiness; excludes parasomnias. Extreme daytime sleepiness: Interferes with alertness and vigilance; usually associated with obstructive sleep apnea or narcolepsy. Insomnia: Ongoing difficulty with the onset, duration, or quality of sleep, despite sufficient opportunity for sleep, and associated with daytime impairment. Narcolepsy: Dysregulation of REM sleep involving depletion of a neuropeptide. Non–rapid eye movement (NREM) sleep: Includes four stages of sleep, from transitional or light sleep characterized by slow, regular brain activity on polysomnography (Stage 1) to slow wave or deep sleep characterized by stable respiration and minimal response to environmental stimuli (Stages 3 and 4). Obstructive sleep apnea (OSA): Repeated episodes of pharyngeal collapse during sleep with resulting hypoxia and hypercarbia. Parasomnias: Physical disorders that occur during sleep. Periodic limb movement disorder (PLMD): Periodic episodes of repetitive, highly stereotyped limb movements during sleep that lead to partial arousal or awakening. Polysomnography (PSG): Record of electrical brain activity, eye movement, and muscle tension during sleep. Rapid eye movement (REM) sleep: Deep and light stages of sleep associated with dreaming, highfrequency brain activity, rapid eye movements, irregular breathing, and rapid heart rate.

Fatigue and Sleep Disorders 111



Restless legs syndrome (RLS): Unpleasant sensation in the legs during rest, relieved with movement and interfering with sleep. Sleep architecture: Distribution of sleep stages as measured by PSG. Tiredness: Daytime fatigue that usually does not impact alertness or vigilance. Ultradian process: Alternating NREM and REM sleep.

Epidemiology Research on the prevalence and patterns of adolescent sleep disorders is both sparse and methodologically limited by differences in definition and measurement. Although large-scale epidemiological studies of sleep disturbances in adolescents are lacking, there are accumulating data on the rates of specific sleep disorders and symptoms. For example, reported prevalence rates for symptoms of insomnia and diagnoses of insomnia in adolescents range from 5–35% and 4–13%, respectively. Among adolescents with insomnia, 7% are reported to have a circadian disorder in which the internal sleep/ wake cycle is asynchronous with external cues. Studies of adolescents in the general population have revealed snoring in 26–29% and diagnoses of OSA in 0.1–3%. Narcolepsy is much less common, with an estimated prevalence across all ages of 4–10 per 10,000.

Pathophysiology Sleep Physiology Laboratory studies suggest that circadian and homeostatic systems are responsible for regulating the sleep and wake processes (Figure 17-1). The circadian pace-

S

maker in the anterior hypothalamus is entrained to the 24-hour day and receives its strongest external cues through phototransduction along the retinohypothalamic tract. The circadian system therefore drives lightor clock-dependent wakefulness. In contrast, the homeostatic system drives sleep propensity, architecture, and duration. Slow wave sleep (SWS), which is proportionally highest when sleep need is greatest, appears to be a marker of homeostatic drive. Total daily sleep time and the ratio of NREM to REM sleep decrease steadily across the human lifespan, as shown in Figure 17-2. Children ages 9–10 years sleep approximately 10 hours daily regardless of weekday or weekend, whereas adolescents 14–18 years of age sleep an average of 7.5 hours daily on school days. Despite the decline in sleep time with adolescence, Carskadon and colleagues have demonstrated that 9 hours of sleep daily are required from ages 10 to 17 years. Furthermore, even when sleep duration is held constant in older and younger adolescents, the drive (i.e., need) to sleep appears to be greater in older than in younger adolescents. Developmental trends in sleep behavior during adolescence are summarized in Box 17-1.

Environmental Factors Affecting Sleep Family, school, extracurricular activities, and work affect sleep pattern and quality. Only 5% of high school students report a set bedtime on school nights, and 85% require an alarm or parent to wake them on school mornings. Early start times for high school are the norm nationwide, with more than a third starting before 7:30 a.m. Several studies have demonstrated that earlier start times are associated with shorter daily sleep times and more daytime sleepiness as measured objectively by the speed of falling asleep in a controlled setting. Other studies of after-school work have demonstrated that high school students employed 20 or more hours weekly have shorter daily sleep times and higher rates of oversleeping in the morning, falling asleep in school, and substance use than students employed less than 20 hours weekly.

C Waking 7

Sleep 23

Effects of Inadequate Sleep 7

23

7

Time of day

Figure 17-1

Two-process model of sleep regulation: time course of homeostatic process (S) and circadian process (C).

Recreated from: Borbely AA,Acherman P: Sleep homeostasis and models of sleep regulation. In Kryger MH, Roth T, Dement WC (eds): Principles and Practice of Sleep Medicine. Philadelphia, Saunders, 2000, pp. 377–390. Modified from: Borbely AA: A two-process model of sleep regulation. Hum Neurobiol 1982;1:195–204.

The literature on inadequate sleep differentiates excessive daytime sleepiness from tiredness or fatigue. Both excessive daytime sleepiness and tiredness are consequences of insufficient or poor-quality sleep, but excessive daytime sleepiness is more severe than tiredness and is more common in adults than adolescents. Excessive daytime sleepiness interferes with alertness and vigilance and is usually associated with clinical syndromes such as narcolepsy and OSA. Tiredness or fatigue may lead to

112 Adolescent Medicine: The Requisites in Pediatrics

Total daily sleep (hr)

20

NREM REM

Recreated from:Anders TF, Sadeh A,Appareddy V: Normal sleep in neonates and children. In Ferber R, Kryger M (eds): Principles and Practice of Sleep Medicine in the Child. Philadelphia, Saunders, 1995, pp. 7–18. Anders and colleagues state this figure is based on the previously published data source: Roffwarg HP, Munzio JN, Dement WC: Ontogentic development of human sleep-dream cycle. Science 1966;152: 604–619.

10

5

0 1–15 3–5 6–23 2–3 days mos mos yrs

3–9 yrs

5–9 10–13 14–18 19–30 33–34 50–70 70–85 yrs yrs yrs yrs yrs yrs yrs

adverse long-term sequelae but tends to have limited impact on daytime alertness and vigilance. Research in adults has demonstrated that insufficient sleep is associated with declines in cognitive function, task performance, vigilance, and mood stability. Studies in adolescents have demonstrated that later bedtimes and shorter sleep times are associated with decreased academic performance, poor concentration, increased daytime tiredness, and sleeping in school. Evidence supports a bidirectional association between adolescent sleep disturbance and mood disorders. In other words, adolescents with sleep problems appear to have diminished mood regulation and adolescents with depression are at increased risk for disordered sleep. Many studies have explored a potential association of attention-deficit/hyperactivity disorder (ADHD) with sleep problems. Although lack of sleep has clearly been shown to cause decreased attention in controlled settings and parents commonly report sleep problems in

Box 17-1  Developmental Trends in

Adolescent Sleep Practices

l

l

l

l

l

Figure 17-2 Changes in total daily sleep, REM sleep, and NREM sleep with age.

15

Bedtimes delay over the course of adolescence, especially on weekend nights. Rise times delay on weekends but are held in check on weekday by early school start times. Total sleep time decreases more on weekdays than weekends. The discrepancy between weekday and weekend sleep increases as adolescence progresses. The magnitude of this discrepancy is linked to problems such as impaired school performance and depressed mood.

Source: Carskadon MA, Acebo C: Regulation of sleepiness in adolescents: Update, insights, and speculation. Sleep 2002;25:606–614.

children with ADHD, objective measures have not demonstrated consistent differences in the sleep patterns of children with and without ADHD. More recent studies suggest that the inconsistencies may reflect varying adjustment for factors such as pharmacotherapy (e.g., stimulant medications) and comorbid conditions (e.g., depression, anxiety). Drivers aged 16–29 years constitute the age group with the highest rate of motor vehicle crashes caused by falling asleep at the wheel. The likelihood of a sleeprelated crash is nearly five times greater for drivers who sleep less than 5 hours nightly than for those who sleep 8 or more hours nightly.

Evaluation and Management The adolescent history and physical examination should include an assessment of sleep quality, quantity, and consequences. Owens and Dalzell developed a pediatric screening tool called the “BEARS” that divides sleeprelated problems into five broad categories (Box 17-2) and provides sample questions within each category. When a sleep disorder is suspected, the International Classification of Sleep Disorders, 2nd Edition (ICSD-2)

Box 17-2  “BEARS” Pediatric Sleep

Assessment

B  E  A  R  S 

Bedtime problems Excessive daytime sleepiness Awakenings during the night Regularity and duration of sleep Sleep-disordered breathing

Source: Owens JA, Dalzell V: Use of a pediatric sleep screening tool in the primary care setting: A pilot study. J Dev Behav Pediatr 2000;21:389–390.

Fatigue and Sleep Disorders 113



provides a tool to aid clinical assessment and an organizational system for classification (Box 17-3). This system divides sleep disorders into eight categories based on common complaint, presumed etiology, or organ system from which the problems arise. ICSD-2 defines insomnia as the almost-nightly or nightly complaint of too little sleep or not feeling rested after a night’s sleep. Parasomnias are not disorders of sleep/wake regulation but rather are physical phenomena that primarily occur during sleep. The following sections discuss sleep disorders that are particularly common or important during adolescence: psychophysiologic insomnia, delayed sleep phase syndrome, obstructive sleep apnea, restless legs syndrome, and periodic limb movement disorder.

Psychophysiologic Insomnia (PI) As outlined in Box 17-4, PI is a conditioned sleep disorder characterized by somatic tension and learned associations that prevent sleep.  The patient typically describes a cycle of trying to fall asleep; overconcern about not sleeping; and agitation, which in turn interferes with falling asleep. Without treatment, PI can persist for decades. The combination of psychological arousal and learned behavioral response has led to clinical trials exploring the efficacy of cognitive behavioral therapy (CBT) for the management of PI. CBT seeks to modify both the dysfunctional attitudes about sleep and the sleep-related practices associated with those attitudes. Well-controlled clinical trials have demonstrated that CBT alone is more effective in the long-term management of PI than CBT plus pharmacotherapy or pharmacotherapy alone. In the short term, CBT plus pharmacotherapy may lead to greater improvement. There are currently no sleep medications labeled for use in children or adolescents by the U.S. Food and Drug Administration (FDA). In addition, there are no controlled clinical trials examining the efficacy of medication for

Box 17-3  ICSD-2 Classification Outline I Insomnias II Sleep-Related Breathing Disorders III Hypersomnias of Central Origin IV Circadian Rhythm Sleep Disorders V Parasomnias VI Sleep-Related Movement Disorders VII Isolated Symptoms, Apparently Normal Variants and Unresolved Issues VIII Other Sleep Disorders Source: American Academy of Sleep Medicine: The International Classification of Sleep Disorders: Diagnostic and Coding Manual, 2nd ed. Westchester, IL, American Academy of Sleep Medicine, 2005.

Box 17-4  Diagnostic Criteria for

Psychophysiologic Insomnia

A conditioned sleep problem and/or arousal in bed characterized by one or more of the following manifestations:  

l

 

l

   

 

l l

l

 xcessive focus on and heightened anxiety about E sleep. Difficulty falling asleep at the desired bedtime or during planned naps, without difficulty falling asleep during monotonous activities when not intending to do so. Ability  to sleep better away from home than at home. Mental arousal in bed characterized either by intrusive thoughts or a perceived inability to volitionally cease sleep-preventing mental activity. Heightened somatic tension in bed reflected by a perceived inability to relax the body sufficiently to allow the onset of sleep.

Source: American Academy of Sleep Medicine: The International Classification of Sleep Disorders: Diagnostic and Coding Manual, 2nd ed. Westchester, IL, American Academy of Sleep Medicine, 2005.

the treatment of adolescent insomnia. Important issues to consider when prescribing sleep medications for adolescents are potential abuse of the medication and/or interaction with alcohol, marijuana, or other drugs. In adults, non-benzodiazepines that function as benzodiazepine receptor agonists (NBRAs) are now considered first-line pharmacotherapy for insomnia. Compared with benzodiazepines, NBRAs (e.g., zolpidem, zaleplon) have shorter half-lives, shorter durations of action, and lower rates of abuse.

Delayed Sleep Phase Syndrome (DSPS) A circadian rhythm disorder called DSPS is thought to be the cause of insomnia in 7% of adolescents, compared with 0.7% of adults. The underlying mechanism is asynchrony between the internal pacemaker and external time. Bedtime is delayed until 2:00 to 6:00 a.m., and wake time is delayed until 10:00 a.m. to 6:00 p.m. Daytime function is characterized by oversleeping on school days, falling asleep in class, poor school performance, after-school naps, and catch-up sleeping on weekends. When the adolescent is allowed to sleep on the preferred schedule, sleep quality is normal and sleep complaints resolve. The treatment of DSPS always involves a change in the timing of sleep in an effort to synchronize the circadian rhythm with the desired sleep/wake schedule. When sleep onset is delayed by 3 hours or less, treatment involves “phase advance,” in which sleep and wake times move earlier by 15 minutes daily until the desired bedtime

114 Adolescent Medicine: The Requisites in Pediatrics

lence of childhood OSA is highest at 2–6 years when lymphoid hyperplasia peaks and during adolescence. The adolescent surge in OSA also reflects the rapid weight gain of puberty and resulting obesity for many youth. SDB is four to five times more common in obese than non-obese children. The mechanisms for pediatric OSA include adenotonsillar hypertrophy; increased upper airway resistance associated with fatty tissue in the throat, neck, and chest wall; alteration of the central ventilatory drive; and craniofacial anomalies causing upper airway narrowing and decreased neuromuscular tone. Daytime symptoms of OSA may include excessive daytime sleepiness, difficulty waking in the morning, mood dysregulation, externalizing behavioral problems, inattention, poor concentration, and distractibility. There is accumulating evidence suggesting that OSA and/or poor-quality sleep increase the risk for obesity and cardiovascular morbidity in children and adolescents. The treatment of OSA depends on its cause. Tonsillectomy and adenoidectomy (T&A) is indicated for patients with adenotonsillar hypertrophy. Although this usually results in resolution of the OSA, close postoperative monitoring is essential because 32% of subjects with PSG-documented OSA develop acute complications such as hemorrhage or respiratory decompensation. Nasal continuous positive airway pressure (CPAP) should be considered for patients who do not respond to T&A or for whom surgery is not indicated. Although several studies have demonstrated its efficacy for the treatment of pediatric OSA, side effects are common and limit ­ compliance

is achieved (Figure 17-3). In some cases, setting the wake time at the targeted goal from the beginning of treatment promotes bedtime sleepiness and hastens the phase advance. When sleep onset is delayed by more than 3 hours, phase delay (i.e., chronotherapy) is recommended. Although this approach takes advantage of the tendency for an adolescent’s endogenous pacemaker to delay sleep, staying awake becomes increasingly difficult.  The success of chronotherapy depends on adolescent motivation and parental support. Phototherapy and low-dose (1–3 mg) melatonin are adjunctive interventions for DSPS. Patients with mild DSPS may improve with morning exposure to natural sunlight and evening avoidance of bright lights. Those with moderate or severe DSPS usually require bright-light (e.g., 10,000-lux) exposure via a light box or therapeutic lamp 20–30 minutes daily for 2–4 weeks. Regardless of the treatment, success depends on daily adherence to the new sleep and wake times.

Obstructive Sleep Apnea (OSA) Sleep-disordered breathing (SDB) refers to the continuum of respiratory conditions ranging from primary snoring to OSA (Figure 17-4). OSA is characterized by repetitive episodes of partial or complete obstruction of the upper airway during sleep that results in hypoxemia, hypercapnia, and/or respiratory arousals. Multiple arousals resulting from apneic events lead to sleep fragmentation and daytime dysfunction. The prevaFigure 17-3 Circadian rhythm treatment. A. Phase Advance Schedule

Bedtime Baseline

12:00 A.M.

1st night

11:30 P.M. 11:15 P.M.

3rd night 5th night

9:00 A.M.

11:45 P.M.

2nd night 4th night

Wake time

11:00 P.M.

8:45 A.M. 8:30 A.M.

8:15 A.M. 8:00 A.M.

10:45 P.M.

7:45 A.M.

(Advance bedtime/wake time by 15 minutes nightly until desired schedule is reached)

B. Phase Delay Schedule (chronotherapy)

Baseline 1st night 2nd night 3rd night 4th night 5th night Goal night

Bedtime

Wake time

4:00 A.M.

1:00 P.M. 7:00 A.M.

4:00 P.M. 10:00 A.M.

7:00 P.M.

1:00 P.M.

10:00 P.M. 4:00 P.M.

1:00 A.M. 7:00 P.M.

4:00 A.M. 10:00 P.M.

7:00 A.M.

Fatigue and Sleep Disorders 115

Airway collapsibility and/or resistance



Normal

Primary snoring (PS)

Upper airway resistance syndrome (UARS)

Obstructive hypoventilation (OH)

Obstructive sleep apnea syndrome (OSAS)

Figure 17-4 Spectrum of sleep-disordered breathing in adolescents. Recreated from: Katz ES, Marcus CL: Diagnosis of obstructive sleep apnea syndrome in children. In Sheldon SH, Ferber R, Kryger MH, et al. (eds): Principles and Practice of Pediatric Sleep Medicine. Philadelphia, Elsevier Saunders, 2005, pp. 197–210. Katz et al. adapted this figure from Loughlin GM: Obstructive sleep apnea syndrome in children: Diagnosis and management. In Loughlin GM, Carroll JL, Marcus CL (eds): Sleep and Breathing in Children: A Developmental Approach. New York, Marcel Dekker, 2000, pp. 625–650.

with nightly use. Common complaints include nasal ­congestion, dryness, and rhinorrhea; eye irritation; facial dermatitis; claustrophobia; and difficulty exhaling. Desensitization training and/or work with a behavioral ­psychologist may improve adherence. Although weight loss is routinely recommended for all obese adolescents, there is little published research regarding its effectiveness in the treatment of adolescent OSA. Oral appliances have been used effectively in adults with mild OSA and in those who could not tolerate CPAP, but there is little evidence to support their use in children and adolescents. Nasal steroids may help mild OSA in children, but pharmacotherapy generally is of limited benefit.

Restless Legs Syndrome (RLS) and Periodic Limb Movement Disorder (PLMD) RLS is described as unpleasant sensations in the legs at night that are relieved by leg movement and that interfere with sleep. PLMD is characterized by periodic episodes of repetitive, stereotypic movements of the legs and/or arms that occur during sleep and often lead to partial or full awakening. The minimum diagnostic criteria for PLMD include documentation on PSG of limb movements with the following characteristics: duration of 0.5–5 seconds, amplitude > 25% of toe dorsiflexion during calibration; more than four movements in sequence; episodes separated by an interval > 5 seconds and < 90 seconds; more than five episodes hourly in children; and disturbed sleep and/or daytime fatigue. More than 90% of children with PLMD in a clinically referred sample met the criteria for ADHD. Patients with RLS and low serum ferritin have been shown to improve with iron supplementation. Symptom

management of both RLS and PLMD in adults typically includes pharmacotherapy with agents such as carbidopa-levodopa, pergolide, pramipexole, benzodiazepines, or gabapentin.

Narcolepsy Narcolepsy is a chronic neurological condition that is characterized by dysregulation of REM sleep and extreme daytime sleepiness. Classic symptoms include cataplexy, or the sudden loss of muscle tone triggered by strong emotion (e.g., laughter, surprise, anger, sadness); auditory, visual, and/or sensory hallucinations during the transition to/from sleep; sleep paralysis, or the inability to move or talk during the transition to/from sleep; and sleep attacks when sedentary and understimulated. Untreated narcolepsy can lead to high levels of functional impairment associated with extreme daytime sleepiness. The treatment of narcolepsy includes stimulant medications such as methylphenidate and dextroamphetamine. More recently, agents promoting alertness, such as modafinil, have been successfully used to treat narcolepsy. When cataplexy is severe and causes functional disability or places an individual at risk for injury, REM-suppressant agents such as tricyclic antidepressants and serotonin reuptake inhibitors may be used. However, because there are no randomized clinical trials of medication efficacy in adolescents with ­narcolepsy, caution must be taken when using pharmacological treatment. In addition to medication, treatment should also include patient education and psychosocial support, maintenance of appropriate sleep hygiene, use of short restorative naps when indicated, and avoidance of activities that may pose a safety risk (e.g., driving).

116 Adolescent Medicine: The Requisites in Pediatrics



l

l

l

l

l

l

l

l

l

Major Points

b

The interaction between the biological and sociocultural determinants of sleep results in a developmental vulnerability for sleepiness during the teenage years. Children ages 9–10 years sleep approximately 10 hours daily regardless of weekday or weekend, whereas adolescents 14–18 years of age sleep an average of 7.5 hours daily on school days. Despite the decline in sleep time during adolescence, 9 hours of daily sleep are required from ages 10–17 years. Studies in adolescents have demonstrated that later bedtimes and shorter sleep times are associated with decreased academic performance, poor concentration, increased daytime tiredness, and sleeping in school. Psychophysiologic insomnia is a conditioned sleep disorder characterized by somatic tension and learned behavioral associations that prevent sleep. Cognitive behavioral therapy has been shown to be effective for long-term management. Delayed sleep phase syndrome is asynchrony between the internal pacemaker and external time. Treatment involves resetting the internal clock through incremental change in sleep and wake times and/or phototherapy. Obstructive sleep apnea is characterized by repetitive episodes of partial or complete obstruction of the upper airway during sleep that results in hypoxemia, hypercapnia, and/or respiratory arousals. Treatment depends on underlying cause, such as T&A for tonsillar hypertrophy and CPAP. Restless legs syndrome consists of unpleasant sensations in the legs during rest that are relieved with leg movement and interfere with sleep. Usual treatment in adults includes pharmacotherapy. Narcolepsy is characterized by dysregulation of REM sleep and extreme daytime sleepiness and is typically associated with cataplexy, sleep attacks, sleep paralysis, and hallucinations when transitioning to/from sleep. Treatment includes psychostimulant medication.

Bibliography American Academy of Sleep Medicine: The International Classification of Sleep Disorders: Diagnostic and Coding Manual, 2nd ed. Westchester, IL, American Academy of Sleep Medicine, 2005. Amin R, Daniels S: Relationship between obesity and sleepdisordered breathing in children: Is it a closed loop? J Pediatr 2002;140:641–643. Beebe DW, Wells CT, Jeffries J, et al.: Neuropsychological effects of pediatric obstructive sleep apnea. J Int Neuropsychol Soc 2004;10:962–975. Carskadon MA, Acebo C: Regulation of sleepiness in adolescents: Update, insights, and speculation. Sleep 2002;25:606–614. Dahl RE, Lewin DS: Pathways to adolescent health sleep regulation and behavior. J Adolesc Health 2002;31(6 Suppl): 175–184. Dijk DJ, Lockley SW: Integration of human sleep-wake regulation and circadian rhythmicity. J Appl Physiol 2002;92:852–862. Ferber R, Krieger M (eds): Principles and Practice of Sleep Medicine in the Child. Philadelphia, Saunders, 1995. Gupta NK, Mueller WH, Chan W, et al.: Is obesity associated with poor sleep quality in adolescents? Am J Hum Biol 2002;14: 762–768. Jenni OG, Achermann P, Carskadon MA: Homeostatic sleep regulation in adolescents. Sleep 2005;28:1446–1454. Krieger MH, Roth T, Dement WC (eds): Principles and Practice of Sleep Medicine. Philadelphia, Saunders, 2000. Mindell JA, Owens JA: A Clinical Guide to Pediatric Sleep: Diagnosis and Management of Sleep Problems. Philadelphia, Lippincott Williams & Wilkins, 2003. O’Brien EM, Mindell JA: Sleep and risk-taking behavior in adolescents. Behav Sleep Med 2005;3:113–133. Owens JA, Dalzell V: Use of a pediatric sleep screening tool in the primary care setting: A pilot study. J Dev Behav Pediatr 2000;21:389–390. Sheldon SH, Kryger MH, Ferber R (eds):  Principles and Practice of Pediatric Sleep Medicine. Elsevier Saunders, 2005, pp. 197–210. Wyatt JK: Delayed sleep phase syndrome: Pathophysiology and treatment options. Sleep 2004;27:1195–1203.

18

ChA p t e r

Introduction Disorders of the Back Scoliosis Kyphosis Spondylolysis and Spondylolisthesis Back Pain

Disorders of the Hip Slipped Capital Femoral Epiphysis Legg-Calvé-Perthes Disease Stress Fracture Avulsion Fractures of the Pelvic Apophyses

Disorders of the Knee Acute Knee Pain Chronic Knee Pain

Back, Hip, and Knee Disorders James R. Ebert, MD, MBA

Disorders of the Back Vertical growth of the spine accelerates early in puberty and continues at a slower pace up to age 25 years. Normal spinal elongation depends on synchrony between the superior and inferior growth plates located within each vertebral body, as well as on the structural integrity of the vertebral bones and disc spaces. Asynchrony in vertebral growth or alignment therefore can result in accentuated spinal curvature laterally (i.e., scoliosis), posteriorly (i.e., kyphosis), or anteriorly (i.e., lordosis) (Table 18-1). These developmental anomalies are described next, followed by an approach to the evaluation and management of adolescents with back pain.

Scoliosis Introduction The spine, hips, and knees are greatly affected by the acceleration in growth during adolescence. Activation of key growth plates in the vertebrae, femur, and tibia are responsible for the normal skeletal elongation as well as many of the musculoskeletal problems that characterize adolescence. This chapter focuses on con­ ditions of the back, hip, and knee that present during adolescence. The first section reviews scoliosis, kyphosis, lordosis, and back pain. The second section reviews slipped capital femoral epiphysis, Legg-Calvé-Perthes disease, and hip fracture. The third section reviews the common causes of acute and chronic knee pain in adolescents. The common developmental anomalies are defined, and strategies for early detection and appropriate referral are discussed.

Scoliosis refers to abnormal alignment of the vertebral bodies in the anteroposterior, or frontal, plane. Most scoliotic deformities detected during the second decade of life are idiopathic. However, scoliosis can be secondary to leg-length discrepancy or congenital anomalies of vertebral structure; neuropathic disorders such as cerebral

Table 18-1 Direction of the Convexity and Spinal Regions Affected in Scoliosis, Kyphosis, and Lordosis Term

Convexity

Regions

Scoliosis Kyphosis Lordosis

Lateral Posterior Anterior

Thoracic, lumbar Thoracic Cervical, lumbar

117

118 Adolescent Medicine: The Requisites in Pediatrics

palsy, spinal cord tumor or trauma, and poliomyelitis; and myopathic disorders such as muscular dystrophy. Leg lengths that differ by as little as 0.5 cm can produce pelvic tilting toward the shorter side and spinal convexity toward the longer side. Any adolescent with leg-length discrepancy who is still growing should be referred for orthopedic evaluation. Congenital scoliosis usually presents before adolescence and is commonly associated with spinal cord (40%), genitourinary (20%), and cardiac (10%) malformations. Although congenital scoliosis typically presents before age 10 years, it progresses in 75% of patients during the rapid growth phase of adolescence. Neuromuscular scoliosis tends to progress steadily and should be treated early and monitored closely with ­periodic radiographs. Idiopathic scoliosis has no known cause, tends to be milder than secondary scoliosis, and is characterized by its age at onset. Adolescent idiopathic scoliosis begins at age 11 years, is far more common than juvenile and infantile scoliosis, and is more likely to occur and to progress in girls than boys. Family history is positive in 30% of adolescents with idiopathic scoliosis, but no specific gene or pattern of inheritance has been identified. Right thoracic curves are most common, followed by combined right thoracic, left lumbar, and isolated left lumbar. Screening asymptomatic adolescents for scoliosis through school programs and primary care visits is common in North America despite limited evidence of its cost-effectiveness. In adolescents aged 11 years and older, prevalence estimates are 2.5% for curves of at least 10 degrees and 0.1–1.0% for curves greater than 20%. Using the forward bend test (see below) as a screen for scoliosis, referral rates for positive tests range from 3–30%. The variability in false-positive rates and the concern about unnecessary treatment of mild scoliosis led the U.S. Preventive Services Task Force (USPSTF) to recommend against the routine screening of asymptomatic adolescents. The USPSTF wrote that it had not found good evidence that screening was associated with earlier detection of idiopathic scoliosis and that it had found at least fair evidence that the harms of screening may outweigh the benefits. In Guidelines for Adolescent Preventive Services (GAPS), the American Medical Association concurs with the USPSTF and makes no recommendation for routine scoliosis screening. In contrast, both the American Academy of Pediatrics and the U.S. Maternal and Child Health Bureau recommend annual screening of adolescents during routine primary care visits (see Chapter 2). The physical examination for scoliosis begins with visual inspection of the back, waistline, and shoulders while the adolescent is standing with the feet together and the arms by the sides. The adolescent then should bend forward with the head and hands hanging toward the floor, and the back should be inspected for lateral

curvature of the spine, elevation of the hemithorax, and protrusion of the scapula (Figure 18-1). If the forward bend test, with or without a scoliometer, reveals evidence of scoliosis, standing posteroanterior and lateral radiographs of the entire spine should be obtained. The Cobb method can then be used to estimate the angle between the most tilted vertebrae at both ends of the curve (Figure 18-2). Lines perpendicular to the proximal end-plate of the upper vertebra and the distal end-plate of the lower vertebra are drawn. The angle of their intersection estimates the degree of curvature. This radiographic examination is considered the standard for quantifying the scoliotic curve. The management of idiopathic scoliosis depends on the magnitude of the curve and the likelihood of progression, which in turn depends on curve magnitude, curve location, and skeletal maturity. Ossification of the iliac crest apophysis on the spinal radiograph, rated by Risser sign from zero (no ossification) to five (complete ossification), provides a reliable measure of skeletal maturity. The likelihood of curve progression during adolescence increases with lower Risser sign, younger age, premenarcheal status in girls, larger curve angle at diagnosis, thoracic location, and double curve pattern. Once skeletal maturity is achieved, the major determinants of progression during adulthood are a Cobb angle above 50 degrees, vertical rotation above 30 degrees, and thoracic location. Adult sequelae of untreated adolescent idiopathic scoliosis include the psychological impact of the spinal deformity, chronic back pain, and restrictive lung disease for curves above 100 degrees. Orthopedic consultation for adolescents with idiopathic scoliosis is recommended if the curvature exceeds

Figure 18-1 Examination of the spine.

Back, Hip, and Knee Disorders 119



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Figure 18-2

A. Posteroanterior radiograph of the spine showing adolescent idiopathic scoliosis. B. Radiographic determination of the Cobb angle in the same patient.

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B 10 degrees or progresses at least 5 degrees between examinations. Curves less than 25 degrees are followed by serial examination alone. Although bracing typically is recommended for curves of 25–40 degrees, there is no evidence that it results in long-term correction of the curvature. Surgery is reserved for patients with idiopathic scoliosis exceeding 45 degrees. The usual procedures are implantation of internal fixation rods and fusion of the affected vertebrae.

Kyphosis Kyphosis is posterior curvature of the thoracic spine that exceeds the normal range of 20–45 degrees. Scheuermann kyphosis is characterized by anterior wedging of the vertebral bodies and irregularities of the vertebral end-plates at three or more levels, with consequent inability to correct the round back by active hyperextension. This is in contrast to postural round back, which is characterized by normal vertebrae and disc spaces, temporary correction with active hyperextension, and long-term improvement with hyperextension exercises of the back. The prevalence of Scheuermann kyphosis is 4–8%. Males are twice as likely to be affected as females, and the risk of severe disease appears particularly high in tall males. The cause remains unknown, although there is some evidence that transient osteoporosis following prolonged immobi-

lization may result in vertebral compression fractures with subsequent wedging. Pain is the usual presenting complaint of patients with Scheuermann kyphosis. It is gradual in onset, has no clear precipitating event, is worse with activity, and improves with rest. When the adolescent bends forward at the waist, examination from the side reveals sharp angulation of the thoracic spine. The most commonly affected vertebrae are T7–T9 and T10–T12. Radiographic examination of the entire spine should be performed with standing lateral and posteroanterior views. Oblique views should also be considered because of the association of Scheuermann kyphosis with spondylolysis (see below). All patients with Scheuermann kyphosis warrant orthopedic consultation. Observation may be all that is required for adolescents with non-progressive curves that are less than 50 degrees. Bracing or surgery is indicated for larger or rapidly progressive curves to prevent chronic pain and impaired pulmonary function.

Spondylolysis and Spondylolisthesis The words spondylolysis and spondylolisthesis are derived from the Greek spondylos (vertebra), lysis (break), and listhesis (slipping). Spondylolysis is a unilateral or bilateral defect in the pars interarticularis, which is the narrow neck of bone between the superior and

120 Adolescent Medicine: The Requisites in Pediatrics

inferior articular processes that extend posteriorly from the vertebral body. Spondylolisthesis is the forward slippage of one vertebra on the vertebra below it. The severity is expressed as a percentage, ranging from grade I (0–25%) to grade V (more than 100%). The percentage is calculated as 100 times the ratio of the forward displacement to the vertebral width. The forward displacement is the misalignment of the superior to inferior vertebrae, measured in millimeters. Vertebral width is the anteroposterior width of the inferior vertebra. In children and adolescents, the most common causes of spondylolysis and spondylolisthesis are congenital dysplasia of the articular processes and acquired deformities of the pars. Activities involving spinal impact and hyperlordosis, such as gymnastics and wrestling, increase the risk of acute fracture, chronic separation, and elongation of the pars. Spondylolysis and spondylolisthesis are more common in adolescent males than females, but progressive slippage is more likely in females than males. The signs and symptoms of spondylolysis and spondylolisthesis are back pain, tight hamstrings, bent-knee gait, bent-hip gait, and nerve root impingement with highergrade slippage. If the oblique, anteroposterior, and lateral radiographs of the spine are unremarkable, bone scan or CT scan should be considered (Figure 18-3). Asymptomatic spondylolysis requires no treatment. If pain is present, activities involving impact and hyperextension should be discontinued. Physical therapy can help with exercises to stretch tight hamstrings and strengthen anterior spinal and abdominal muscles. The treatment of spondylolisthesis is determined by the adolescent’s symptoms and the radiographic measure of slippage (Figure 18-4). Asymptomatic patients with grade I spondylolisthesis are followed with observation alone. Patients with painful grade I slippage are candidates for bracing. Surgery is indicated for patients with slippage that is progressive or grades III–V and for those with nerve impingement. The usual procedure involves fusion of the L4 and L5 vertebrae to the sacrum.

Back Pain Back pain is more likely to have a discernable etiology in adolescents than adults. Although self-limited muscle strain is the most common cause, the developmental conditions discussed earlier in this chapter and the inflammatory, infectious, and neoplastic processes summarized in Box 18-1 should always be considered. Psychogenic back pain is a diagnosis of exclusion, particularly when the pain awakens the adolescent at night or is associated with neurologic findings, fever, weight loss, or other ­systemic signs of illness. Adolescents are much less likely than adults to have degeneration of the disc with herniation of the nucleus

pulposus. When degenerative disc disease does occur in adolescents, it often follows acute trauma or is precipitated by an underlying developmental anomaly such as Scheuermann kyphosis. Infectious causes of back pain in adolescents include vertebral osteomyelitis, epidural abscess, paraspinal muscle abscess, pyelonephritis, pelvic inflammatory disease, and pneumonia. Discitis probably represents a low-grade, selflimited bacterial infection of the intervertebral disc space. The incidence peaks in early childhood and is rare in adolescence. Although the etiology of discitis remains uncertain, the limited data that are available suggest that the high vascularity of the disc space in young children contributes both to hematogenous seeding and an aggressive immune response that contains the local infection. Fever is reported in fewer than 25% of patients, the white blood cell count typically is normal, and blood cultures are negative. In more than 90% of patients, however, the erythrocyte sedimentation rate is elevated. Magnetic resonance imaging (MRI) often shows changes in the vertebral end-plates in addition to the expected inflammatory changes of the disc, suggesting an association between discitis and early vertebral osteomyelitis. Despite its uncertain cause, discitis usually is treated with intravenous antibiotics until the pain diminishes, followed by several weeks of oral antibiotics. Spondyloarthropathy is an important consideration in the adolescent with persistent back pain. The term refers to a group of arthritides that begin during the second decade of life and involve the sacroiliac joint and/or large joints of the lower extremities. Specific diagnoses within this group include juvenile ankylosing spondylitis, Reiter syndrome, psoriatic arthritis, and the axial arthropathy associated with inflammatory bowel disease. The history should include questions about morning stiffness, weight loss, abdominal pain, diarrhea, and blood per rectum. Physical examination may reveal limitation on flexion of the waist or hips and asymmetrical arthritis of the knees or ankles. Erythrocyte sedimentation rate may be normal or elevated, and antinuclear antibodies may be positive in patients with psoriatic arthritis. Rheumatoid factor is typically negative. MRI is the most sensitive study for the detection of early sacroiliitis. If spondyloarthropathy is diagnosed or suspected, referral to a rheumatologist is warranted.

Disorders of the Hip Adolescents with problems related to the hip usually present with pain. Its location can be misleading, however, because the first symptom of hip disease may be pain referred to the knee. Similarly, patients with disorders of the lumbosacral spine may present with pain referred to the hip or knee. Any adolescent with hip pain, knee pain, or limp should therefore have a careful examination performed of the spine, hips, and knees.

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D Figure 18-3 A. Radiograph of spondylolysis with arrow pointing to lysis of pars interarticularis. B. Oblique view in the same patient. C. SPECT scan demonstrating L5-S1 spondylolysis. D. Computed tomography with arrows demonstrating spondylolysis.

122 Adolescent Medicine: The Requisites in Pediatrics

Box 18-1 Differential Diagnosis of Back

Pain in Adolescents

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Figure 18-4 Lateral radiograph of the spine showing nearly 50% slippage in an adolescent with grade II spondylolysthesis.

Examination of the adolescent’s gait is essential when a hip disorder is suspected. Unilateral disease may result in a tendency to lean over the affected hip (Trendelenburg gait) or to unload the affected leg more quickly than the unaffected leg (antalgic gait). The clinician also should examine hip range of motion when the adolescent is in the supine position. If pain is elicited when the clinician holds the thigh and rolls the entire leg in and out (log-roll test), the hip is the probably source of the pain.

Slipped Capital Femoral Epiphysis Slipped capital femoral epiphysis (SCFE) is a hip disorder of early to mid-adolescence in which the normal alignment of the femoral head and neck is disrupted by slippage at the epiphyseal plate. The name of the disorder is misleading because the femoral head remains in the acetabulum while the femoral neck moves proximally and anteriorly. The onset of SCFE correlates with the peak height velocity at approximately ages 10–13 years for girls and 12–15 years for boys. Although the left hip is more commonly involved than the right, bilateral involvement occurs in at least 20% of cases. The annual incidence of SCFE ranges from 0.2 per 100,000 in Japan to 10 per 100,000 in the northeastern United States. Males outnumber females at a ratio of 1.4 to 1.0. The major risk

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Mechanical and Developmental l Acute muscle strain l Overuse injury l Fracture l Herniated nucleus pulposus l Spondylolysis l Spondylolisthesis l Scheuermann kyphosis l Advanced scoliosis Inflammatory and Infectious l Juvenile rheumatoid arthritis l Ankylosing spondylitis l Other rheumatological conditions l Discitis l Vertebral osteomyelitis l Tuberculous spondylitis l Pneumonia l Pelvic inflammatory disease l Appendicitis l Pyelonephritis l Retroperitoneal abscess Neoplastic l ○Leukemia/lymphoma l Ewing sarcoma l Spinal cord and meningeal tumors l Rhabdomyosarcoma l Metastatic tumors l Benign tumors Psychogenic

factor for SCFE is obesity, and the age of presentation is younger for obese than non-obese children. The presentation of SCFE is highly variable. The pain may be sudden or insidious in onset; constant or intermittent; and may localize to the hip, knee, or thigh. In 90% of cases there is no history of trauma or temporal association with a particular event. Inability to walk indicates severe slippage and risk for subsequent osteonecrosis. More commonly, the patient presents with a waddling gait and lateral rotation of the affected leg. On physical examination, the log-roll test produces pain with lateral rotation of the thigh and marked limitation of motion with medial rotation. Importantly, isolated movement of the knee when the thigh and hip are stabilized causes no pain. When SCFE is suspected, radiographic examination of the hip should be obtained with anteroposterior (AP) and lateral views in the frog-leg position. The AP view demonstrates widening of the physis and displacement of the femoral neck proximally and anteriorly. The lateral view demonstrates posterior displacement of the epiphysis relative to the femoral neck (Figure 18-5).

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Figure 18-5 A. Anteroposterior radiograph of the hip showing slipped capital femoral epiphysis with arrow pointing to the site of slippage. B. Frog-leg view of the same patient. C.  Anteroposterior view of the same patient following in-situ screw fixation. D.  Frog-leg view of the same patient following in-situ screw fixation.

SCFE is an orthopedic emergency. The patient should be hospitalized and restricted to bed rest upon diagnosis. The operative procedure of choice is single-screw fixation to prevent further slippage. Intentional reduction of the existing displacement increases the risk of osteonecrosis and should not be attempted. A second procedure can be performed later, when the physis has closed, if limited mobility or pain persists. The outcome of SCFE is related to the degree of slippage and the operative success of stabilization. The major adverse outcomes are osteonecrosis and chondrolysis, or dissolution of the cartilage of the hip joint. Improvements in operative technique have led to decreases in the rates of both complications.

Legg-Calvé-Perthes Disease Legg-Calvé-Perthes disease is most common in children between the ages of 4 and 8 years. It is mentioned in this chapter because it can present as late as age 12 and carries a poorer prognosis for adolescents than younger children. Legg-Calvé-Perthes disease involves a temporary decrease in blood flow to the femoral head, with subse-

quent remodeling and structural deformity. The pathophysiology is divided into four phases: (1) synovitis, lasting up to 3 weeks; (2) osteonecrosis, lasting up to 1 year; (3) fragmentation of the femoral head, lasting approximately 1 year; and (4) revascularization and remodeling, lasting up to 3 years. The cause of Legg-Calvé-Perthes disease is unknown, but its association with hypercoagulation disorders (e.g., deficiencies of protein C or S) suggests that impaired venous drainage and increased pressure in the femoral head may cause the transient decrease in arterial supply. The variability in age of onset and phase duration leads to variability in presentation. Limping and pain tend to be most severe in phases 1 and 3. Once the permanent flattening of the femoral head occurs in phase 4, there may be shortening of the affected leg. The evaluation of patients with suspected Legg-CalvéPerthes disease includes AP and frog-leg radiographic views of the hip. Once the diagnosis is confirmed, laboratory studies should be performed to exclude coagulopathy and other causes of osteonecrosis, and the patient should be referred for orthopedic evaluation. Milder cases can be managed with bed rest, traction, crutches, physical therapy, bracing, and/or casting. More severe

124 Adolescent Medicine: The Requisites in Pediatrics

cases require surgery to obtain better containment of the femoral head within the acetabulum.

Stress Fracture Stress fracture of the femoral neck is the most serious overuse injury involving the hip and is usually associated with distance running. Stress fractures of the inferior pubic ramus, superior pubic ramus, and ischial ramus are less common overuse injuries, usually seen in females with amenorrhea. The incidence of stress fracture, regardless of site, increases with age. The pathophysiology involves

repeated loading of the bone with accumulated microtrauma resulting in the development of a bony defect. Stress fractures of the hip and pelvis present with pain in the hip, groin, or knee that worsens with physical activity and improves with rest. With femoral neck fracture, there may be tenderness of the groin and hip range of motion is decreased. With pelvic stress fracture, hip range of motion may be normal but there usually is pain on palpation of the affected bone and difficulty standing on one leg. Radiographs may not reveal small or early stress fracture. If the diagnosis is strongly suspected, bone scan or MRI is indicated (Figure 18-6).

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Figure 18-6 A. Anteroposterior radiograph showing a stress fracture in the neck of the right femur. B. T1-weighted magnetic resonance imaging of the same patient. C. T2-weighted magnetic resonance imaging of the same patient.

Back, Hip, and Knee Disorders 125



Treatment depends on the location of the fracture. Stress fracture of the superior femoral neck may require surgical repair to prevent complete fracture and displacement. Fractures involving other portions of the femoral neck or pelvis may heal adequately with restriction of activity until the patient is free of pain.

Avulsion Fractures of the Pelvic Apophyses Pelvic avulsion fracture peaks during the adolescent growth spurt and is caused by the forceful contraction of a muscle against an immature apophysis. The three most common types involve the anterior superior iliac spine, where the sartorius muscle originates; the anterior inferior iliac spine, where the rectus femoris originates; and the ischial tuberosity, where the hamstrings and adductors originate (Table 18-2). Hip or groin pain is the usual presenting symptom, with tenderness or swelling over the involved apophysis. Plain radiographs may appear normal until compared with radiographs of the unaffected hemipelvis or may show obvious displacement at the fracture site (Figure 18-7 and Figure 18-8). Normal radiographs in the patient with persistent pain suggest traction apophysitis without fracture and warrant bone scan or CT scan. The treatment of pelvic avulsion fracture begins with crutches until callus is evident radiographically, followed by limited weight-bearing and positioning so as to minimize traction of the muscle on the injured apophysis. Avulsions with displacement of 2 cm or more may require open reduction and internal fixation.

Figure 18-7

Anteroposterior radiograph of the pelvis showing an avulsion fracture of the anterior inferior iliac spine. Arrow indicates the site of fracture.

Disorders of the Knee Knee disorders during adolescence typically involve the interface between bone, cartilage, and tendon. The rapid skeletal growth during puberty coupled with the athleticism of many teens increases the likelihood of both overuse and acute injury to the knee. The initial evaluation of an adolescent with knee pain should focus on identifying

Table 18-2 Bone–Muscle Groups Involved in Pelvic Avulsion Fracture and Apophysitis Bone

Muscle

Anterior superior iliac spine Anterior inferior iliac spine Ischial tuberosity Lesser trochanter of the femur Iliac crest Greater trochanter of the femur

Sartorius Rectus femoris Hamstring, adductors Iliopsoas Abdominal obliques Piriformis

Figure 18-8 Anteroposterior radiograph of the pelvis showing an avulsion fracture of the lesser trochanter of the left femur.

those conditions that warrant prompt surgical intervention. General indications for immediate orthopedic consultation are inability to bear weight within minutes of an injury, increasing effusion or hemarthrosis within hours of an injury, gross structural deformity of the knee, and evidence of neurovascular compromise. It is important to remember that up to two-thirds of knee fractures and most injuries involving tendon and cartilage are not apparent on plain radiographs of the knee. The history and physical examination therefore are particularly important in narrowing the differential diagnosis in an adolescent with knee pain.

126 Adolescent Medicine: The Requisites in Pediatrics

The discussion that follows is divided into two sections. The first section reviews acute disorders of the adolescent knee, usually associated with single injuries. The second section reviews chronic disorders, usually associated with overuse injuries.

Acute Knee Pain Sudden-onset knee pain can be caused by fractures (Figure 18-9 and Figure 18-10), bony contusions (Figure 18-11), ­ dislocations (Figure 18-12), ligamentous and meniscal injuries, muscle and tendon strains, and chondral lesions. Common causes of acute knee pain during adolescence are described below. Knee dislocation usually is caused by high-velocity trauma, such as a motor vehicle accident, and involves anterior or posterior dislocation of the tibia relative to the femur. Damage to the popliteal artery and peroneal nerve occur in one-third and one-quarter of patients with knee dislocation, respectively. Immediate orthopedic consultation should be obtained. Anterior cruciate ligament (ACL) sprain or tear is caused by twisting or hyperextension of the knee while the foot is planted. It occurs most commonly in female basketball and soccer players and, in 50% of cases, is ­associated with injury to the medial collateral ligament (MCL) or the menisci. Acute ACL injury is associated with sudden-onset pain, a popping sensation in the knee, and trouble walking. Patients with ACL sprains may be able to bear weight and walk but avoid twisting, pivoting, or changing the direction of the gait. Physical examination demonstrates an effusion and positive Lachman test. Initial treatment consists of rest, ice, compression, and a knee immobilizer. All ACL injuries warrant orthopedic referral. Medial collateral ligament (MCL) sprain or tear is caused by a side impact, or valgus force, to the extended knee. It is common in skiing and tackling injuries and may be accompanied by injury to the lateral meniscus.

Figure 18-10 T2-weighted coronal magnetic resonance imaging showing a fracture of the inferior pole of patella.

Figure 18-11 T2-weighted magnetic resonance imaging showFigure 18-9 Sunrise-view radiograph of a lateral patellar fracture.

ing a contusion of the medial patella.

Back, Hip, and Knee Disorders 127



The patient may experience a tearing sensation in the knee followed by pain, swelling, stiffness, and instability. Physical examination reveals tenderness on palpation of the MCL and pain with valgus stress at 30 degrees flexion. Pain and instability with valgus stress at full extension suggests both MCL and ACL injury. Tenderness along the distal femur suggests an associated physeal fracture and warrants radiographic examination in all patients who are still growing. The management of isolated MCL sprains includes rest, ice, compression, and a hinged knee brace. Rehabilitation should begin early to preserve ­muscle strength and joint motion. Surgical reattachment of the MCL generally is unnecessary, even in cases of complete rupture. Meniscal tear is caused by rotation or twisting of the knee as it bears weight (e.g., landing from a jump). The symptoms of acute meniscal injury include pain, locking, popping, and clicking. Physical examination reveals tenderness along the joint line, effusion, and painful clicking on the McMurray test. Although plain radiography does not confirm the diagnosis, it should be performed with AP, lateral, sunrise, and tunnel views to exclude fracture and osteochondritis dissecans. MRI often will demonstrate a meniscal tear, and the size and location of the tear can help guide the decision about arthroscopic repair. Referral to an orthopedic surgeon is recommended for all suspected meniscal injuries. Posterior cruciate ligament (PCL) sprain or tear is caused by trauma to the upper, anterior tibia when the knee is in the flexed position. Common settings are dashboard impact to the passenger’s flexed knee during a motor vehicle accident and a fall onto the flexed knee from a bicycle. The acute pain tends to be less severe with PCL than ACL or MCL sprain. Physical examination, however, usually reveals positive posterior drawer and posterior sag tests. Lateral collateral ligament (LCL) sprain or tear is caused by an outwardly directed blow (varus force) to the medial knee, usually sustained in a motor vehicle accident. Physical examination reveals tenderness along the LCL and painful instability on varus testing at 30 degrees flexion. Instability on varus testing at full extension suggests injury to multiple ligaments. Muscle strain or tear around the knee most commonly involves the hamstring, rectus femoris, gastrocnemius, and adductor longus. When the injury is acute, hematoma may accompany the muscular pain and tenderness is noted on palpation.

These causes include developmental disorders of the hip (e.g., SCFE), knees (e.g., genu valgum), or feet (e.g., pes planus); rheumatological disorders; infection of the bone or joint; and benign or malignant tumors of bone. The most common causes of chronic knee pain during adolescence are discussed below. Patellofemoral syndrome accounts for up to 80% of chronic knee pain in adolescent females and up to 30% in adolescent males. It is caused by overuse injury at the articulation of the patellar and femoral bones and is

A

Chronic Knee Pain Chronic knee pain during adolescence is usually associated with overuse injury from repeated activity or failure to rehabilitate a previous acute injury. Causes unrelated to sports or injury must also be considered, however.

Figure 18-12 A. Tunnel-view radiograph of dislocated patella. B. Sunrise view radiograph of same patient.

128 Adolescent Medicine: The Requisites in Pediatrics

usually associated with impact activities such as running and jumping. Anomalies of patellar alignment (i.e., shift laterally or superiorly), size, and shape increase the risk of patellofemoral syndrome. Lateral drift may be caused by weakness of the quadriceps femoris muscles, variant attachment of the vastus medialis muscle, femoral neck anteversion, or genu valgum. The patellofemoral syndrome presents with the insidious onset of pain around or behind the knee that increases with flexion-extension activities such as walking stairs and arising from prolonged sitting. Physical examination of the knee reveals pain with medial or lateral traction and with compression of the patella into the femoral groove. Range of motion is normal, but joint effusion may be present and flexion or extension may elicit crepitation if the syndrome has advanced to degeneration of the articular cartilage (i.e., chondromalacia patellae). Radiographs help to exclude other conditions but usually contribute little to the diagnosis of patellofemoral syndrome. When ordered, radiographic examination should include AP and lateral views, as well as a tangential view of the patellofemoral joint (i.e., merchant or sunrise view). The management of patellofemoral syndrome begins with restriction of activities such as running, jumping, and squatting; nonsteroidal anti-inflammatory agents for pain and swelling; and physical therapy with the development of a home rehabilitation plan. Orthotic shoe inserts and knee bracing may be helpful for selected patients but should not replace the program of joint rest followed by muscle strengthening. The outcome in patellofemoral syndrome is related to the severity of misalignment, adherence to physical therapy, and the intensity or frequency of the exacerbating activity. Patellar dislocation can be a recurrent complication of the patellofemoral syndrome, unassociated with acute injury. Reduction usually occurs spontaneously. However, persistent dislocation should be manually reduced by flexing the patient’s hip, extending the knee, and gently returning the patella to the femoral groove. Radiographs are usually taken to exclude fracture and are normal following reduction. Pre-reduction radiographs are shown in Figure 18-12. When obtained, an MRI may demonstrate injury to the articular cartilage. Treatment of recurrent patellar dislocation includes a cast or knee immobilizer for 2–4 weeks followed by physical therapy to strengthen the vastus medialis oblique and improve range of motion. Orthopedic referral is recommended for all patients with dislocation of the patella. Osgood-Schlatter disease is a unilateral or bilateral apophysitis of the anterior tibial tubercle that coincides in onset with the adolescent growth spurt. Rapid growth of the femur and tibia during this period can cause tightness of the hamstring and quadricep muscles,

traction of the patellar tendon against the tibial tubercle, repeated microtrauma to the tubercle, and ultimately inflammation of the apophysis. Most adolescents with Osgood-Schlatter disease have histories of overuse related to running and jumping activities, but acute trauma to the tibial tubercle in the absence of overuse can also cause the apophysitis. The presenting symptom of Osgood-Schlatter disease is anterior knee pain exacerbated by activity and relieved with rest. Physical examination typically reveals tenderness of the tibial tuberosity and, less commonly, swelling or warmth over the tuberosity. An important prerequisite to the diagnosis is a normal examination of the knee joint. Although radiographs of the knee may demonstrate fragmentation at the anterior tibial tubercle, the characteristic history and physical findings usually make radiographic examination unnecessary for the diagnosis of Osgood-Schlatter disease (Figure 18-13). The management of Osgood-Schlatter disease begins with reassuring the adolescent and family of its benign course. In nearly all patients, the pain resolves with completion of growth. During the growth phase, the pain responds to limitation of the exacerbating activity,

Figure 18-13 Radiograph showing Osgood-Schlatter disease with soft-tissue swelling.

Back, Hip, and Knee Disorders 129



the use of nonsteroidal anti-inflammatory agents, and flexibility exercises to stretch the hamstrings and quadriceps. As patients return to sports participation, knee pads can be worn to prevent reactivation by contact injury. Persistent pain may require the use of an immobilizing brace for a few weeks to enforce limitation of activity. Corticosteroid injection into the tibial tubercle is contraindicated for Osgood-Schlatter disease as it may result in weakening and rupture of the patellar tendon. Sinding-Larsen-Johansson syndrome is a traction apophysitis of the lower pole of the patella. Like Osgood-Schlatter disease, it can recur throughout adolescence until the physis fuses and presents as knee pain associated with activity. Unlike Osgood-Schlatter disease, physical examination reveals tenderness of the inferior patella rather than the tibial tuberosity. Although unnecessary for diagnosis, radiographic examination may show fragmentation of an ossicle at the inferior pole of the patella. Treatment is the same as described for Osgood-Schlatter disease, and full recovery is the usual outcome. Osteochondritis dissecans is a condition involving the articular cartilage and subchondral bone of the femoral condyle. A fragment of cartilage or bone separates from the joint surface of the medial, or less commonly, the lateral femoral condyle. It can occur at any age, but most cases present between ages 13 and 17 years. The pathophysiology is thought to involve genetic factors, repetitive microtrauma, and compromised blood supply to the affected bone. The major presenting symptom is the insidious onset of knee pain that increases with strenuous activity and extension movements. Physical examination of the knee when flexed to 90 degrees reveals tenderness of the femoral condyle. Other findings may include swelling, locking, or a palpable free body in the joint. Plain radiographs usually confirm the diagnosis (Figure 1814), but grade and prognosis may be influenced by the appearance of the cartilage on MRI. Management varies from reduced sports participation to knee immobilization by casting or bracing. If serial radiographs demonstrate progressive fragmentation despite these interventions, surgery may be indicated to remove or secure fragments and improve circulation to the affected condyle. Cruciate ligament insufficiency and meniscal injury can present together as chronic knee pain, swelling, and instability. Chronic meniscal injuries alone present as intermittent pain along the joint line and swelling, without joint instability. Iliotibial band syndrome is a condition of runners that presents as pain over the lateral femoral condyle, where it is crossed by the band of connective tissue that extends from the ileum to the fibula. Contributing fac-

tors include band shortening, varus alignment of the knee, and excessive or high-impact running. The physical examination reveals local tenderness over the lateral femoral condyle, occasional clicking over the condyle, and an otherwise normal knee.

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Major Points

b

Screening for scoliosis in early adolescence reduces the need for surgery. Treatment is determined by the degree of curvature and the stage of skeletal maturity. Scheuermann kyphosis is a deformity of the spine that may present as back pain during adolescence. Improvement with physical therapy is unlikely, in contrast to postural round back. Spondylolysis indicates a defect in the pars interarticularis, and spondylolisthesis indicates actual slippage of one vertebra on another. Both are caused by repeated hyperextension and loading of the lower spine. Back pain in adolescence increases in incidence with age. Although psychogenic back pain occurs, an identifiable source is more common in teens than in adults. Adolescents presenting with back pain deserve a careful history, a thorough physical examination, and radiographs and laboratory studies as indicated. Knee pain in adolescents may be caused by hip pathology. Although much more common in early childhood, Legg-Calvé-Perthes disease can still present in early adolescence. Slipped capital femoral epiphysis is an orthopedic emergency. Bilateral involvement occurs about 20% of the time, and the opposite side may be asymptomatic. Obesity is a commonly associated factor. Osgood-Schlatter disease is a common apophysitis that almost universally resolves with closure of the physis. Patellofemoral syndrome is a common source of knee pain in adolescence. Its incidence is nearly three times greater in girls than boys. An increased Q-angle, femoral anterversion, genu valgum, external tibial torsion, and anatomical variations of the patella may be contributing factors. Osteochondritis dissecans of the knee is appearing at younger ages. Onset is usually insidious, and there may be a history of knee “locking.” Mechanism of injury is important in taking the history of an injured knee. The sensation of a “pop” or “snap” during injury is significant and can suggest ligament sprain. ACL injuries can occur in combination with MCL injuries, and mensical injuries can occur in combination with ACL or MCL sprains.

130 Adolescent Medicine: The Requisites in Pediatrics

B

A

C Figure 18-14 A. Anteroposterior radiograph of the knee showing osteochondritis dissecans invo­ lving the lateral femoral condyle. B. Tunnel radiograph of the same process. C. Lateral radiograph of the same process.

Back, Hip, and Knee Disorders 131



Acknowledgments The author wishes to thank Elizabeth Ey, M.D., Medical Director of Medical Imaging, The Children’s Medical Center of Dayton, Ohio for her assistance in providing the radiographs used in this chapter. Bibliography Anderson SJ: Lower extremity injuries in youth sports. Pediatr Clin North Am 2002;49:627–641. Baker CL (ed): The Hughston Clinic Sports Medicine Book. Philadelphia, Williams & Wilkins 1995, p. 21. Burton AK, Clarke RD, McClune TD, et al.: The natural history of low back pain in adolescents. Spine 1996;21:2323–2328. Canale ST: Campbell’s Operative Orthopaedics, 10th ed. Philadelphia, Mosby, 2003, pp. 1758–1836.

Hensinger RN: Spondylolysis and spondylolisthesis in children and adolescents. J Bone Joint Surg Am 1989;71:1098–1107. Kealey WD, Mayne EE, McDonald W, et al.: The role of coagu­ lation abnormalities in the development of Perthes’ disease. J Bone Joint Surg Br 2000;82:744–746. Krause BL, Williams JP, Catteral A: Natural history of OsgoodSchlatter disease. J Pediatr Orthop 1990;10:65–68. Morrissy R, Weinstein S (eds): Lovell & Winter’s Pediatric Orthopaedics, 5th ed. Philadelphia, Lippincott William & Wilkins, 2001. Rowe DE, Bernstein SM, Riddick MF, et al.: A meta-analysis of the efficacy of non-operative treatments for idiopathic scoliosis. J Bone Joint Surg Am 1997;79:664–674. Stanitski CL, DeLee JC, Drez D (eds): Pediatric and Adolescent Sports Medicine. Philadelphia, WB Saunders, 1994, pp. 279– 293.

Carney BT, Weinstein SL: Natural history of untreated chronic slipped capital femoral epiphysis. Clin Orthop Relat Res 1996;Jan(322):43–47.

U.S. Preventive Services Task Force: Screening for Idiopathic Scoliosis in Adolescents: Recommendation Statement. June 2004. Agency for Healthcare Research and Quality, Rockville, MD. Available from: http://www.ahrq.gov/clinic/3rduspstf/ scoliosis/scoliors.htm. Accessed May 17, 2007.

DeLee JC, Drez D, Jr, Miller MD (eds): DeLee & Drez’s Orthopa­ edic Sports Medicine, Vol 2. Philadelphia, WB Saunders, 1994.

Weinstein SL (ed): The Pediatric Spine: Principles and Practice, 2nd ed. Philadelphia, Lippincott William & Wilkins, 2001.

Dormans JP, Pill SG: Benign and malignant tumors of the spine in children. Spine: State of the Art Reviews 2000;14:263–280.

Weinstein SL, Dolan LA, Spratt KF, et al.: Health and function of patients with untreated idiopathic scoliosis:A 50-year natural history study. JAMA 2003;289:559–567.

Dormans JP (ed): Pediatric Orthopedics: Core Knowledge in Orthopaedics. Philadelphia, Elsevier Mosby, 2005. Ginsburg GM, Bassett GS: Back pain in children and adolescents: Evaluation and differential diagnosis. J Am Acad Orthop Surg 1997;5:67–78.

Sexual and Reproductive Health



Pa r t

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19

C h Ap t e r

Introduction Definitions Epidemiology Gender and Sexual Identity Sexual Behavior

Evaluation Management

Introduction Sexual identity and behavior are challenging issues for individuals, families, and society. The resulting tensions can be particularly trying when an idealized concept of normal denies the sexual variation that exists within every population. Although the formation of sexual identity is a key developmental task of adolescence, parents and clinicians rarely discuss it openly with teenagers. Parents, wanting their children to grow without undue social scrutiny or pressure, may be alarmed by any deviation from an assumed social norm. Clinicians, uncertain how to counsel or reassure, may avoid the sexual history altogether or forego those questions pertaining to sexual identity. The goals of this chapter are to provide an evidencebased review of sexual identity and sexual behavior during adolescence. It begins with a definition of commonly used terms related to sexuality and a review of the epidemiology of sexual orientation and behavior during adolescence. The chapter focuses on the adolescent sexual history as a core component of the routine evaluation and the management of issues related to gender identity, sexual identity, and sexual behavior.

Definitions Asexual: Lack of sexual attraction or desire. Bisexual: Sexual desire directed toward members of both sexes.

Sexual Identity and Behavior Michael G. Spigarelli, MD, PhD

Chromosomal sex: Classification of gender based upon chromosomal analysis. Gender: Differentiation between male and female of a species. Gender identity: Knowledge of being male or female. Gender role: Outward expression of maleness or femaleness. Heterosexual: Sexual desire directed toward members of the opposite sex. Homosexual: Sexual desire directed toward members of the same sex. Phenotypic sex: Classification of gender based upon the appearance of the external genitalia. Sexual identity: Self-assessment as heterosexual, homosexual, bisexual, or asexual. Sexuality: Interest in sexual activity or behavior. Sexual orientation: Individual’s pattern of sexual arousal toward other individuals. Transgender: An individual who is in transition or has already transitioned to the opposite sex. Transvestite: An individual who gains sexual satisfaction by dressing as the opposite sex. Transsexual: An individual with a desire to live as a member of the opposite sex.

Epidemiology Gender and Sexual Identity Phenotypic sex, or the classification of male–female gender based on the appearance of the external genitalia, typically is determined at birth. An estimated 1.9 per 100 newborns have anomalies of the external genitalia that may delay gender definition, and 1 per 1500 individuals have chromosomal patterns other than XX or XY. Ambiguities of external phenotypic sex are sorted out socially, if not medically, early in life. Regardless of phenotype or genotype, many ­individuals 135

136 Adolescent Medicine: The Requisites in Pediatrics EVER HAD SEXUAL INTERCOURSE 70

Percent (%)

50 40 30 20 10 0 9

10

11

12

Average

Grade

Figure 19-1 Percentage of high school students by grade reporting sexual intercourse ever. Adapted from: Centers for Disease Control and Prevention. Surveillance Summaries, May 21, 2004. MMWR 2004:53(No. SS-2).

Available from: http://www.cdc.gov/HealthyYouth/yrbs/index. htm. Accessed May 17, 2007. CURRENTLY SEXUALLY ACTIVE (WITHIN PAST 3 MONTHS) 60

Female Male Total

50 40 30 20 10 0 9

Sexual Behavior The U.S. Youth Risk Behavior Survey (YRBS), conducted biannually since 1991, provides national data on the health-risk behaviors of 9th- to 12th-grade students. As shown in Figures 19-1, 19-2, and 19-3, the proportions of males and females who report sexual intercourse ever, within the past three months, and with more than four lifetime partners increase steadily between 9th and 12th grades. Factors associated with sexual initiation in early adolescence include early pubertal development; past history of sexual abuse; poverty; parental neglect; cultural or family patterns of early sexual experience; lack of school or career goals; school drop-out; and substance abuse (Figure 19-4). Factors associated with delay in sexual initiation include connectedness with parents; family stability; nonparental adult role models; peer role models; academic achievement; future aspirations; and ­religiosity. Studies exploring why adolescents engage in sexual relationships indicate the importance of force, coercion, and older partners. Up to 10% of sexually active teens report at least one episode of physical force, 21% report

Female Male Total

60

Percent (%)

question their sexual identity, and less commonly their gender identity, during adolescence. Discussion of sexual and gender identity should be a routine part of the adolescent history. A clinician who is unable to conduct the discussion without bias or judgment should refer the adolescent to another provider or participate with other providers in the adolescent’s ongoing care. Kinsey’s pioneering work on sexual behavior demonstrated that 28% of males and 17% of females reported at least one homosexual experience by age 20 years and that 10% of adults identified themselves as predominantly homosexual in orientation. A subsequent survey by Sorensen revealed that 11% of males and 6% of females aged 13–16 years and 17% of males aged 16–19 years reported at least one homosexual encounter. In a study of students aged 12–18 years, 11% reported uncertainty about their sexual orientation, 5% reported same-sex attraction, and 1% described themselves as bisexual or homosexual. Using the criteria of sexual desire, identity, and behavior to define homosexual or bisexual orientation in adults, Laumann found that all three criteria were met by 2% of men and 1% of women and that at least one criterion was met by 10% of men and 9% of women. The prevalence of gender identity dysphoria, defined as persistent cross-gender identification and discomfort with one’s assigned sex or gender role of that sex, is unknown. Estimates in adults range from 1 per 2500 for transsexuality to 1 per 30,000 males and 1 per 100,000 females who seek sex-reassignment surgery.

10

11

12

Average

Grade

Figure 19-2

Percentage of high school students by grade reporting sexual intercourse in the past three months. Adapted from: Centers for Disease Control and Prevention. Surveillance Summaries, May 21, 2004. MMWR 2004:53(No. SS-2).

Available from: http://www.cdc.gov/HealthyYouth/yrbs/index. htm. Accessed May 17, 2007.

oral sex to avoid intercourse, and 30% report feeling pressured to have sex. An age discrepancy of six or more years confers a six-fold risk of sexual intercourse for a 13-year-old female and a two-fold risk for a 17-year-old female. Adolescents who are lesbian, gay, bisexual, transsexual, or questioning (LGBTQ) are at increased risk for suicide, substance use, early sexual initiation, abuse, and multiple partners. Suicide is the leading cause of death among LGBTQ youth, and those who are LGBTQ may account for up to 30% of all youth suicides annually. More than 40% of LGBTQ adolescents report suicidal ideation, and 28% report at least one suicide attempt within the ­preceding year.

Sexual Identity and Behavior 137

MORE THAN 4 LIFETIME SEXUAL PARTNERS 25

Female Male Total

Percent (%)

20 15 10 5 0 9

10

11

12

Average

Grade

Figure 19-3 Percentage of high school students by grade reporting more than four lifetime sexual partners.

Adapted from: Centers for Disease Control and Prevention. Surveillance Summ­aries, May 21, 2004. MMWR 2004:53(No. SS-2). Available from: http://www.cdc.gov/HealthyYouth/yrbs/ index.htm. Accessed May 17, 2007.

ALCOHOL OR DRUG USE BEFORE LAST INTERCOURSE 40

Female Male Total

35 Percent (%)

30 25 20 15 10 5 0 9

10

11

12

Average

Evaluation The constant change that characterizes adolescence makes it a time when an inadvertent label or diagnosis may be both incorrect and harmful. This is especially true for labels related to sexual orientation. From a clinical perspective, the goal is to provide a confidential setting in which the adolescent can discuss sexual questions and concerns without bias or label, recognizing that the adolescent’s sexual orientation and behavior may change with maturation. The discussion of sexuality and sexual behavior is best thought of as a process rather than a question or set of questions at one point in time. Although no single interview style has been shown to be most effective, there is evidence to support the use of open-ended questions that progress from topics that are less to more personal. One such approach, summarized by the HEEADSSS mnemonic, evaluates home, eating, education, alcohol, drugs, suicidality, sex, and safety (e.g., sexual abuse). Box 19-1 suggests indirect “trigger questions” that can help guide an interactive discussion of ­sexuality and sexual behavior. An adolescent who is concerned about gender or sexual identity is unlikely to state that as the chief complaint when scheduling the clinical visit. The information is likely to emerge during the course of a visit or over a series of visits as trust and comfort with the clinician and in the clinical setting develop. Time can be an important deterrent to the discussion, particularly when the adolescent’s disclosure comes late in the visit. Expressing respect for the adolescent’s willingness to share highly personal information and appreciation of the adolescent’s trust are important prerequisites to the scheduling of a subsequent visit that allows time for ­further discussion.

Grade

Figure 19-4

Percentage of high school students by grade reporting use of alcohol or drugs prior to last sexual intercourse.

Adapted from: Centers for Disease Control and Prevention. Surveillance Summaries, May 21, 2004. MMWR 2004:53(No. SS-2). Available from: http://www.cdc.gov/HealthyYouth/yrbs/index. htm. Accessed May 17, 2007.

Box 19-1  Trigger Questions for Eliciting

a Sexual History

l

Self-identified sexual orientation during adolescence correlates poorly with sexual behavior. In one study, high school females who self-identified as lesbian or bisexual were as likely as heterosexual females to have had sexual intercourse with a male partner and were more likely to have been pregnant. Adolescents who self-identify as LGBTQ are as likely to have been raised in a heterosexual household as adolescents who self-identify as heterosexual. This leaves many LGBTQ youth without family role models who can help them cope with the social stigma, ­discrimination, and attendant risk.

l l l l l l

l l

What are your thoughts about people your age having sex? What does “having sex” mean to you? What kinds of activities do you include in having sex? Are you involved with anyone now? Have you ever been involved with anyone? Can you tell me about your relationship(s)? Do your friends or parents know about your relationship(s)? What do your friends think about your partner(s)? Has anyone ever touched you in a way that made you uncomfortable?

138 Adolescent Medicine: The Requisites in Pediatrics

Management One of the first questions asked by parents when they suspect or learn of their adolescent’s sexual orientation is “Why?” Little is known about the formation of gender and sexual identity. Theories range from the psychoanalytical Oedipal struggle described by Freud to the psychosocial crises described by Erikson to the biological mechanisms explored in recent research. Several studies have demonstrated differences between heterosexual and homosexual males in the neuroanatomy and neurohormonal activation of regions of the anterior hypothalamus. Although management may include some discussion of cause, current evidence suggests that sexual identity is multifactorial in origin. Searching for an explanation may delay progress toward acceptance without recrimination or blame. Trust of the clinician and comfort in the clinical setting are critical aspects of all health care and are particularly important to the adolescent seeking care related to sexual health. The suggestions listed in Box 19-2 can help foster the adolescent’s relationship with the health care provider and perception that the health care site is welcoming and safe. Aligning patient and provider goals should be a priority for each visit. For example, an adolescent who does not consider contraception important at the moment or a goal for the visit is unlikely to fill a ­prescription for Box 19-2  Providing Health Care for

LGBTQ Youth

l

l

l

l

l

l

Establish a welcoming environment that includes LGBTQ-friendly symbols and provides lesbian and gay health information that can be accessed in a private manner. Provide the opportunity for an open, honest, face-toface conversation about sexual feelings and behaviors. Use gender-neutral terms, and avoid assumptions regarding sexual or gender orientation. Explain that discussing sexual health and behavior is a part of quality health care. Accept that time is required to develop rapport. Same-sex experimentation during adolescence precedes self-identification as gay or lesbian. Avoid labels of sexual orientation unless used by the adolescent. Be sensitive to the risks and stressors experienced by LGBTQ youth. Everyone working within the health care system must understand that discrimination against LGBTQ patients or staff is unacceptable.

Adapted from: Catallozzi M, Rudy BJ: Lesbian, gay, bisexual, transgendered, and questioning youth:The importance of a sensitive and confidential sexual history in identifying the risk and implementing treatment for sexually transmitted infections. Adolesc Med Clin 2004;15:353–367. Gay and Lesbian Medical Association. Available from: http://www.glma.org:16080/medical/clinical/ lgbti_clinical_guidelines.pdf. Accessed May 17, 2007.

the oral contraceptive pill. The visit time would be better spent managing the adolescent’s presenting concern, discussing contraceptive options, and scheduling a follow-up visit to reach a contraceptive decision. Sound medical advice about sexual risk behaviors is far more important to the adolescent’s health outcome than is establishing a label for the adolescent’s sexual orientation. Instead of asking, “Do you have sex with males, females, or both?” the clinician might say, “Can you tell me about your sexual partners?” Health care professionals should provide factual, current, nonjudgmental information in a confidential manner while at the same time paying attention to the special considerations associated with the care of homosexual and bisexual youth (Box 19-3). The health care provider may be one of the first adults with whom an adolescent discusses same-sex feelings or relationships. It is important to remember that although the adolescent’s feelings may not predict adult sexual orientation, the behaviors associated with those feelings may impose health risks regardless of sexual orientation. The clinical goal should be one of support and guidance rather than diagnosis. The health care provider in this scenario has an opportunity to help the adolescent consider different behavioral pathways and consequences. This may include a discussion of when and how to discuss samesex feelings with parents. The clinician can offer to be present when the information is shared and can ­provide ongoing support for both the adolescent and the family. The clinician who feels pressed by a parent to divulge confidential information should realign with the parent around the common goal of optimal health care for the

Box 19-3  Special Considerations for

Homosexual and Bisexual Youth

l

l

l

l

l

l l

l

Clinicians who are uncomfortable with issues of sexual orientation should refer the adolescent to another health care provider. Assure the adolescent that confidentiality will be protected. Discuss with the adolescent whether to include sexual orientation in the medical record. Explain that same-sex feelings and experiences during adolescence do not necessarily define sexual orientation. Identify and counsel the adolescent about sexual risk behaviors. Recognize the mental health risks of LGBTQ youth. Offer support and advice to current or anticipated conflicts with family and/or friends. When referring to other health care providers, ensure that they provide respectful and nonjudgmental care.

Adapted from: Frankowski BL, American Academy of Pediatrics Committee on Adolescence: Sexual orientation and adolescents. Pediatrics 2004;113:1827–1832.

Sexual Identity and Behavior 139



adolescent. In most cases, a parent who requests information will not persist when breaking confidentiality means risking his or her child’s future confidence in the health care provider. When the parent does persist, the health care provider should inform the adolescent of the parental request and suggest that parent, adolescent, and clinician meet together to answer the parent’s questions. Adole­scents who are unable to talk alone with their parents about sexual health issues usually are willing to discuss the issues with the clinician present, especially when they realize that their parents are likely to push for information after leaving the clinician’s office.

 l

l

l

l

l

l

Major Points

b

Adolescent trust and the protection of confidential information is a core component of quality health care, particularly when that care involves sexual health. Discussions of sexual feelings and behavior should begin with gender-neutral language (e.g., partner instead of boyfriend or girlfriend) and should avoid assumptions regarding sexual orientation. Sexual identity formation is a central task of adolescence. Although the sexual behaviors of adolescents have very real effects on health outcome, neither sexual feelings nor behaviors during adolescence predict adult sexual orientation. The prevention of sexually transmitted infections and unintended pregnancy should be discussed with all adolescents, regardless of sexual feelings, behaviors, or orientation. The association of substance use with sexual risk behaviors should be discussed with all adolescents. Health care providers can provide support and counseling for adolescents and parents when sensitive information pertaining to sexual behavior and orientation is shared.

Bibliography Catallozzi M, Rudy BJ: Lesbian, gay, bisexual, transgendered, and questioning youth: The importance of a sensitive and confidential sexual history in identifying the risk and imple­ menting treatment for sexually transmitted infections. Adolesc Med Clin 2004;15:353–367. Centers for Disease Control and Prevention. Surveillance Summaries, May 21, 2004. MMWR 2004: 53(No. SS-2). Available from: http://www.cdc.gov/healthyyouth/yrbs/mmwr.htm. Accessed May 17, 2007. Cotton S, Mills L, Succop PA, et al.: Adolescent girls’ perception of the timing of their sexual initiation: “Too young” or “just right?” J Adolesc Health 2004;34:453–458. Darroch JE, Singh S: Why Is Teenage Pregnancy Declining? The Roles of Abstinence, Sexual Activity and Contraceptive Use.

Occasional Report, New York, The Alan Guttmacher Institute; 1999, No. 1. Available from:http://www.alanguttmacherinsti­ tute.org/pubs/or_teen_preg_decline.html. Accessed May 17, 2007. Duncan P, Dixon RR, Carlson J: Childhood and adolescent sexuality. Pediatr Clin North Am 2003;50:765–780. Frankowski BL, American Academy of Pediatrics Committee on Adolescence: Sexual orientation and adolescents. Pediatrics 2004;113:1827–1832. Garofalo R, Wolf RC, Kessel S, et al.: The association between health risk behaviors and sexual orientation among a schoolbased sample of adolescents. Pediatrics 1998;101:895–902. Goldenring JM, Rosen DS: Getting into adolescent heads: An essential update. Contemp Pediatrics 2004;21:64. Available from: http://www.contemporarypediatrics.com/contpeds/ article/articleDetail.jsp?id=108002. Accessed May 17, 2007. Halpern-Felsher BL, Cornell JL, Kropp RY, et al.: Oral versus vaginal sex among adolescents: Perceptions, attitudes, and behavior. Pediatrics 2005;115:845–851. Hatcher-Kay C, King CA: Depression and suicide. Pediatr Rev 2003;24:363–371. Henshaw, SK: U.S. Teenage Pregnancy Statistics with Comparative Statistics for Women Aged 20–24. New York, The Alan Guttmacher Institute, 2004. Available from: http://www. guttmacher.org/pubs/teen_stats.html.  Accessed May 17, 2007. Kaestle CE, Morisky DE, Wiley DJ: Sexual intercourse and the age difference between adolescent females and their romantic partners. Perspect Sex Reprod Health 2002;34:304–309. Institute for Sex Research, Indiana University, Kinsey AC, Pomeroy WB, Martin CE (eds): Sexual Behavior in the Human Male. Philadelphia, WB Saunders, 1948. Institute for Sex Research, Indiana University, Kinsey AC, Pomeroy WB, Martin CE, et al. (eds): Sexual Behavior in the Human Female. Philadelphia, WB Saunders, 1953. Klein JD, American Academy of Pediatrics Committee on Adolescence: Adolescent pregnancy: Current trends and issues. Pediatrics 2005;116:281–286. Laumann EO, Gagnon JH, Michael RT, et al.: The Social Organization of Sexuality: Sexual Practices in the United States. Chicago, University of Chicago Press, 1994. Saewyc EM, Bearinger LH, Blum RW, et al.: Sexual intercourse, abuse and pregnancy among adolescent women: Does sexual orientation make a difference? Fam Plann Perspect 1999;31:127–131. Saltzburg S: Learning that an adolescent child is gay or lesbian: The parent experience. Soc Work 2004;49:109–118. Savic I, Berglund H, Lindstrom P: Brain response to putative phermones in homosexual men. Proc Natl Acad Sci USA 2005;102:7356–7361. Epub 2005 May 9. Sorensen RC: Adolescent Sexuality in Contemporary America. New York, World Publishing, 1973. Vesely SK, Wyatt VH, Oman RF, et al.: The potential protective effects of youth assets from adolescent sexual risk behaviors. J Adolesc Health 2004;34:356–365. Available from: http://www. glma.org:16080/medical/clinical/lgbti_clinical_guidelines. pdf. Accessed May 17, 2007.

20

Ch A pte r

Introduction Definitions Testicular Torsion Epidemiology and Pathophysiology Evaluation and Management

Torsion of the Appendix Testis Epidemiology and Pathophysiology Evaluation and Management

Epididymitis Epidemiology and Pathophysiology Evaluation Management

Inguinal Hernia, Hydrocele, and Spermatocele Epidemiology and Pathophysiology Evaluation and Management

Varicocele Epidemiology and Pathophysiology Evaluation and Management

Testicular Tumors Epidemiology Pathophysiology Evaluation and Management

Introduction Scrotal disorders often are categorized according to the presence or absence of scrotal pain. The leading causes of acute scrotal pain during adolescence are epididymitis, torsion of the appendix testis, and torsion of the testis. The leading causes of painless scrotal swelling during adolescence are hydrocele, inguinal hernia, varicocele, spermatocele, and—rarely—testicular cancer. This chapter reviews each of these conditions, compares their clinical presentations, and suggests strategies for their evaluation and management. 140

Testicular and Scrotal Disorders Corinne Lehmann, MD, MEd Frank M. Biro, MD

Definitions Hydrocele: Painless, soft collection of fluid located anterior to the testis, within the tunica vaginalis. Processus vaginalis: Peritoneal diverticulum that surrounds the testis. Spermatic cord: Connected to the epididymis and containing the vas deferens and testicular vessels. Spermatocele: Painless, sperm-containing cyst located above or posterior to, and distinct from, the testis. Torsion of the testis: Twisting of the spermatic cord and testis on its vertical axis, leading to obstruction of venous and subsequent arterial flow. Torsion of the testicular appendages: Twisting of a remnant of the Mullerian duct (appendix testis) or Wolffian duct (appendix epididymis). Tunica vaginalis: Space surrounding the anterior testicle where fluid may accumulate. Varicocele: Tortuous collection of veins surrounding the spermatic cord that may be painless or cause mild, chronic pain and that is more common on the left than right.

Testicular Torsion Epidemiology and Pathophysiology Testicular torsion is the most serious cause of acute scrotal pain. It affects 1 in 4000 males younger than 25 years, and 65–80% of cases occur at ages 12–18 years. Studies of children and adolescents with acute scrotal pain reveal that 14–16% have testicular torsion, 14–46% have torsion of the appendix testis, and 35–71% have epididymitis (Table 20-1). The testis normally is positioned vertically within the scrotal sac and is covered anteriorly by the tunica vaginalis.

Testicular and Scrotal Disorders 141



Table 20-1 Clinical Findings Distinguishing Testicular Torsion from Epididymitis Torsion

Epididymitis

Peak age, years Duration of symptoms Similar pain in past Local tenderness Normal testicular lie Color Doppler ultrasound

0–1, 12–16 < 12 hours 10% 20% 50% Decreased flow

C-reactive protein

Normal

8–15 12–72 hours 20% 97% 100% Increased/normal flow Elevated (4×)

Adapted from: Lehmann CE, Biro FM: Male genitourinary disorders. In Osborn LM, DeWitt TG, First LR, et al. (eds): Pediatrics. Philadelphia, Elsevier/Mosby, 2005, p. 1476,Table 227-2.

Patients with testicular torsion commonly have a bilateral “bell clapper” deformity in which the testicle does not attach at its lower pole to the tunica vaginalis. As a result, the testis is excessively mobile and tends to position horizontally rather than vertically within the scrotum. These factors, along with the increase in testicular weight that occurs with puberty, predispose to torsion, or twisting of the testis on the spermatic cord. The twisting initially causes compression of venous flow and edema of the testis and cord, followed by arterial insufficiency, tissue ischemia, and ultimately necrosis of the ­testis.

Evaluation and Management The usual presentation of testicular torsion is the sudden onset of severe, colicky pain in the testicle, scrotum, groin, or lower abdomen that persists for hours and is often associated with nausea and vomiting. Up to onethird of patients with testicular torsion report at least one previous episode of scrotal pain. Testicular torsion can occur intermittently and resolve spontaneously within minutes. Consequently, even brief episodes of pain and swelling warrant urological consultation. Physical examination of the patient with testicular torsion reveals a tender, edematous, elevated testis. The absence of the cremasteric reflex, or normal elevation of the testis that occurs when the upper medial thigh is stroked, has high sensitivity but relatively low specificity for torsion. Elevating the scrotum tends to worsen or has no effect on the pain of torsion but, like the cremasteric reflex, is not a reliable enough finding to confirm or exclude the diagnosis. If the clinical suspicion of testicular torsion is high, surgery without radiological evaluation is indicated, ­particularly if the imaging will delay the intervention. If the diagnosis is uncertain, Doppler ultrasound or nuclear

scintigraphy is indicated to assess testicular blood flow. Patients with torsion tend to have decreased flow, whereas those with epididymitis tend to have normal or increased flow (Table 20-1). However, up to 38% of pubertal boys without torsion are reported to have no identifiable blood flow on ultrasound, and there are case reports of normal flow in the setting of torsion. If there is any question of the correct diagnosis, urological consultation should be obtained immediately. The testis can be salvaged in up to 98% of patients if the torsion is repaired surgically within 6 hours of the onset of pain. Salvage declines to 20% after 12 hours and is close to 0% after 24 hours. A nonviable testis after untwisting the spermatic cord should be removed because its retention carries a 20% rate of postoperative infection. If a bell-clapper deformity is present, the contralateral testis should be explored and, if necessary, scrotal fixation (i.e., orchiopexy) performed. Even when surgery appears successful, up to two-thirds of patients may develop atrophy of either testis.

Torsion of the Appendix Testis Epidemiology and Pathophysiology The testicular appendages are small, pedunculated remnants of the Mullerian duct (appendix testis) or Wolffian duct (appendix epididymis) systems that can twist on their stems, causing ischemia and pain. It tends to occur at younger ages (7–12 years) than testicular torsion, is more common, and is less severe both in presentation and natural history. Blood flow to the testis is normal or increased, and pain usually resolves spontaneously within one week.

Evaluation and Management Unlike the generalized testicular pain and swelling of testicular torsion, the pain associated with torsion of an appendage is less severe, localized to the upper pole of the hemiscrotum, and unassociated with nausea or vomiting. Physical examination may reveal a “blue dot sign” caused by ischemia or necrosis (Figure 20-1) or a reactive hydrocele. The cremasteric reflex is usually intact. The diagnosis is usually evident on history and physical examination, but a Doppler ultrasound or nuclear scan demonstrating increased blood flow to the affected testis can help distinguish it ­further from testicular torsion. Torsion of the testicular appendages is managed conservatively, with scrotal support, bed rest, and analgesics. Surgery to remove the appendage should only be performed if the pain is severe, persists beyond the usual 5–10 day period, or is recurrent. There is no need to explore the contralateral testis.

142 Adolescent Medicine: The Requisites in Pediatrics

active males with epididymitis: nucleic acid amplification testing of a urethral swab or urine sample for C. trachomatis and N. gonorrhoeae or gram stain and culture for N. gonorrhoeae (Chapter 26); urinalysis and urine culture; and testing for syphilis (Chapter 28) and human immunodeficiency virus (HIV) (Chapter 29).

Management

Figure 20-1 Blue dot sign of appendix testis torsion and area of point tenderness.

From Lehmann CE, Biro FM: Male genitourinary disorders. In Osborn LM, DeWitt TG, First LR, et al. (eds): Pediatrics. Philadelphia, Elsevier/Mosby, 2005, p. 1475, Figure 227-3.

Epididymitis Epidemiology and Pathophysiology Epididymitis accounts for 35–71% of cases of acute scrotal pain in adolescents. Two-thirds of cases of epididymitis in patients younger than 35 years are caused by Chlamydia trachomatis (Chapter 26). Other causes include Neisseria gonorrhoeae (Chapter 26), Escherichia coli associated with urinary tract infection or anal intercourse, mycobacterial and fungal infections associated with immunocompromise, and viral infections associated with orchitis. Noninfectious epididymitis is associated with urinary reflux into the epididymis, with resulting inflammation and edema.

Evaluation Epididymitis usually presents with scrotal pain and swelling that progresses gradually over hours to days. There often is a history of urinary urgency or frequency, dysuria, fever, and/or urethral discharge. Physical examination is variable but usually reveals scrotal edema and erythema, a normal cremasteric reflex, and pain relief on elevation of the testis. In some cases, tenderness on palpation can be localized to the epididymis. However, the physical examination may be complicated by edema of the spermatic cord, a reactive hydrocele, or associated orchitis. Laboratory studies may include pyuria and leukocytosis, both of which may also occur in testicular torsion. Doppler ultrasound or nuclear scan typically reveal increased testicular blood flow in epididymitis, in contrast to the decreased flow observed in testicular torsion. The Centers for Disease Control and Prevention (CDC) recommend the following laboratory studies in sexually

The management of epididymitis should be guided by the likely cause. In sexually active males, the CDC recommends ceftriaxone 250 mg intramuscularly once plus doxycycline 100 mg orally twice daily for 10 days. Sexual partners should also be treated presumptively for C. trachomatis and N. gonorrhoeae. When epididymitis is associated with urinary tract infection, the recommended treatment is trimethoprim-sulfamethoxazole, a cephalosporin, or a quinolone for 10–14 days. Other measures that help control pain include scrotal support, bed rest, and nonsteroidal anti-inflammatory drugs (NSAIDs). If symptoms do not improve within 3 days, the patient should be reevaluated for structural anomalies of the urinary tract or other causes of scrotal pain and swelling, such as inguinal hernia, Henoch-Schonlein purpura, trauma, and retrocecal appendicitis.

Inguinal Hernia, Hydrocele, and Spermatocele Epidemiology and Pathophysiology The leading causes of painless scrotal swelling in adolescents are hydrocele, inguinal hernia (Figure 20-2), varicocele (see below), and spermatocele. Less common causes include unilateral, compensatory scrotal enlargement in the setting of a contralateral undescended or rudimentary testis; bilateral macro-orchidism secondary to fragile X syndrome, leukemia, lymphoma, testicular germ cell tumors, or precocious puberty; and idiopathic painless edema of the testis and epididymis that resolves within 48–72 hours. Testicular cancer (see below) is rare in adolescents. Indirect inguinal hernias occur at the internal inguinal ring, where the spermatic cord descends from the abdomen into the inguinal canal. Direct inguinal hernias occur at the external inguinal ring, where the spermatic cord descends from the inguinal canal into the scrotum. Normally, the inguinal rings close and the process vaginalis obliterates after the testicle descends. Patency at either site allows intra-abdominal or inguinal contents to protrude, or herniate, into the groin or scrotum.

Testicular and Scrotal Disorders 143



Ductus deferens Testis Gubernaculum Processus vaginalis Cremaster muscle

Remains of processus vaginalis Tunica vaginalis

Figure 20-2 Anatomy of hernias: diagram illustrating descent of the testes. From Lehmann CE, Biro FM: Male genitourinary disorders. In Osborn LM, DeWitt TG, First LR, et al. (eds): Pediatrics. Philadelphia, Elsevier/Mosby, 2005, p. 1473, Figure 227-1.

Indirect inguinal hernias are located laterally to direct inguinal hernias and are at higher risk for incarceration and strangulation. When a patent process vaginalis allows fluid, but not tissue, to collect within the potential space of the tunica vaginalis, a communicating hydrocele forms. However, the formation of a hydrocele does not require a congenitally patent process vaginalis. In a noncommunicating hydrocele, the fluid may collect in association with torsion of the testis or testicular appendage, epididymitis, orchitis, testicular trauma, or testicular tumor. The prevalence of spermatoceles in adolescents is unknown. Many are subclinical; they are not associated with infertility or malignancy; and surgical removal is only indicated for persistent discomfort.

Evaluation and Management An inguinal hernia presents as a painless groin bulge, unless it is incarcerated. An indirect hernia should be distinguished from a direct hernia because of its higher risk of strangulation. The hernia orifice usually can be localized with a vigorous cough or strain. Ultrasound can help define the anatomy and can differentiate a hernia from a hydrocele or lymph nodes. Inguinal hernias should be repaired surgically because of the risk of incarceration. A hydrocele is diagnosed on physical examination as a soft fluid collection anterior and inferior to the testis that transilluminates. A communicating hydrocele tends to decrease in size at night, when supine, and to increase in size over the course of the day. It should be repaired surgically in an adolescent because of the risk of hernia development. A noncommunicating hydrocele does not change in size with position or straining and is often associated with underlying pathology of the testis or epididymis. It usually resolves with treatment of the underlying problem or spontaneously, without surgery. A spermatocele presents as a cyst distinct from the testis that can transilluminate or feel like a third testicle on physical examination. This is in contrast to a testicular mass,

which is not separate from the ­testis and does not transilluminate. Once confirmed by examination or ultrasound, a spermatocele does not require surgical excision unless there is pain or discomfort.

Varicocele Epidemiology and Pathophysiology A varicocele is a cluster of dilated, tortuous veins around the spermatic cord (Figure 20-3). Varicoceles occur in 10–25% of adolescent males, and 85–90% are left-sided. The cause is unclear, but the left-sided predominance suggests that increased venous pressure is involved. The left spermatic vein joins the left renal vein at a right angle, whereas the right spermatic vein joins the inferior vena cava at an obtuse angle. Consequently, flow is less continuous and hydrostatic pressure is higher on the left than the right. When a right-sided varicocele is present, potential causes of increased venous pressure should be explored, such as situs inversus or obstruction.

Figure 20-3 Left-sided varicocele. From Lehmann CE, Biro FM: Male genitourinary disorders. In Osborn LM, DeWitt TG, First LR, et al. (eds): Pediatrics. Philadelphia, Elsevier/Mosby, 2005, p. 1474, Figure 227-2.

144 Adolescent Medicine: The Requisites in Pediatrics

The possible effect of a varicocele on testicular function is controversial. A study of sexually mature adolescents with varicoceles revealed abnormal semen analyses in 26% and higher gonadotropin levels in those with abnormal than with normal semen. Adult studies indicate that up to one-third of males with infertility have varicoceles but that less than 15% of those with varicoceles have problems with fertility.

Evaluation and Management Patients with varicoceles may have no symptoms, scrotal swelling, or dull discomfort after prolonged standing (Table 20-2). The genital examination should include observation and palpation of the testis in the standing and supine positions, as well as measurement of testicular volume. The gold standard for the diagnosis of varicocele is venography, but it is only indicated for confusing presentations or in conjunction with embolization. Other diagnostic tools, such as thermography, Doppler ultrasound, and scrotal scintigraphy, carry high false-positive rates and are not relied upon for diagnosis. The management of adolescents with varicoceles is controversial. If testicular size is normal, the patient can be followed by physical examination and ultrasound every 6–12 months to evaluate a change in size and/or by semen analysis when sexual maturation (i.e., Tanner Stage 5) is achieved. Indications for repair of a varicocele include testicular volume discrepancy of 2 ml or 20%, persistent pain, bilateral involvement, or very large varicoceles. A rightsided varicocele or a varicocele on either side that persists in the supine position suggests an obstruction to flow and warrants ultrasound evaluation to the level of the left renal vein and inferior vena cava. Procedures for repair of a varicocele include embolization of the spermatic vein, microsurgical varicocelectomy, and testicular vein ligation. The Palomo approach (i.e., ligation of the testicular vein and artery above the inguinal ring) has a low rate of postoperative testicular atrophy but a 16% rate of varicocele recurrence. The

Table 20-2 Grading Classification for Varicoceles Grade Clinical Description 0 1 2

3

Not palpable or visible at rest; demonstrated by imaging Small; palpable only with Valsalva maneuver Moderate; not visible but palpable; described as a “bag of worms” or “squishy tube” when palpating the spermatic cord Large; visible from door

Adapted from: Lehmann CE, Biro FM: Male genitourinary disorders. In Osborn LM, DeWitt TG, First LR, et al. (eds): Pediatrics. Philadelphia, Elsevier/Mosby, 2005, p. 1474,Table 227-1.

long-term effects of testicular artery ligation are unknown, making the microsurgical varicocelectomy the procedure of choice for many surgeons. The rate of postoperative hydrocele is low (0–7%), and the 9–16% rate of varicocele recurrence due to unrecognized collaterals decreases to 6% with intraoperative venography.

Testicular Tumors Epidemiology The incidence of testicular cancer begins to increase at ages 15–19 years and peaks at ages 25–29 years. It accounts for 20% of cancers in males aged 15–35 years and 1% of cancers in males of all ages. Risk factors for testicular cancer include history of childhood malignancy, history of cryptorchidism (10% of testicular cancer cases), contralateral testicular cancer, family history of testicular cancer, androgen insensitivity, Klinefelter syndrome, Down syndrome, and infection with HIV.

Pathophysiology Germ cell tumors comprise 75% of testicular tumors that present before puberty and 95% that present after puberty. The most common type in adolescents is seminoma, followed by embryonal cell, choriocarcinoma, teratoma, yolk sac, and mixed forms. Most testicular tumors in adolescents are considered curable with surgery and radiation therapy if detected early. Germ cell tumors derive from the intratubular testicular germ cells. Embryonal carcinoma cells are more primitive and undifferentiated, and it is believed other germ cell tumors arise from further differentiation of the embryonal carcinoma (somatic, yolk sac, or trophoblastic lines). However, the more common seminoma does not fit into this scheme and does not have a counterpart that fits into an embryological stage or structure. Consequently, germ cell tumors are usually divided into seminomas and non-seminomas.

Evaluation and Management Although testicular self-examination is often taught to adolescents, there are no data to support its effectiveness as a screening tool. Consequently, the recommendations of the American Academy of Pediatrics do not currently include self-examination but do include annual testicular examination of the adolescent male by the health professional. Testicular cancer usually presents as a painless, firm nodule in the lower pose of the testis that does not transilluminate. Less commonly, the patient may complain of testicular enlargement and a dragging sensation in the

Testicular and Scrotal Disorders 145



scrotum. The presence of pain has been associated with a more advanced stage and with bleeding into the tumor. Immediate urological consultation is indicated if testicular cancer is suspected. The primary care physician can help prepare the patient for the likely evaluation and the possibility of sperm banking. Ultrasound, tumor markers, baseline laboratory work, and computerized axial tomographic (CAT) scan of the abdomen and chest are typically performed prior to treatment. Generally, the patient will undergo radical orchiectomy, followed by a combination of chemotherapy and radiation. The 5-year survival rates for testicular cancer are 92% overall and 70% for those with advanced disease at diagnosis.



Major Points

b

Testicular torsion peaks in incidence during adolescence and presents with acute pain and decreased venous and arterial flow to the involved testis. Surgical repair within 6 hours is associated with a testicular salvage rate of 98%. l Torsion of the testicular appendages peaks in incidence at ages 7–12 years, presents as pain localized to the upper pole of the hemiscrotum, and is associated with normal or increased flow to the involved testis. Pain usually resolves spontaneously within days, without surgery. l Epididymitis accounts for most cases of acute scrotal pain and swelling in adolescents. Two-thirds of cases in males younger than 35 years are due to Chlamydia trachomatis. l The leading causes of painless scrotal swelling in adolescents are hydrocele, inguinal hernia varicocele, and spermatocele. Communicating hydroceles and inguinal hernias are managed surgically. Most varicoceles and spermatoceles do not require surgery. l The incidence of testicular cancer begins to increase at ages 15–19 years and peaks at 25–29 years. Overall 5-year survival is 92%. l

Bibliography Adelman WP, Joffe A: Controversies in male adolescent health: Varicocele, circumcision, and testicular self-examination. Curr Opin Pediatr 2004;16:363–367. Brodsky GL: Pathology of testicular germ cell tumors. Hematol Oncol Clin North Am 1991;5:1095–1126. Diamond DA, Zurakowski D, Atala A, et al.: Is adolescent varicocele a progressive disease process? J Urol 2004;172 (4 Pt 2):1746–1748. Golden CB, Feusner JH: Malignant abdominal masses in children: Quick guide to evaluation and diagnosis. Pediatr Clin North Am 2002;49:1369–1392. Hayes JH: Inguinal and scrotal disorders. Surg Clin North Am 2006;86:371–381. Kadish HA, Bolte RG: A retrospective review of pediatric patients with epididymitis, testicular torsion, and torsion of the testicular appendages. Pediatrics 1998;102(1 Pt 1):73–76. Lewis AG, Bukowski TP, Jarvis PD, et al: Evaluation of acute scrotum in the emergency department. J Pediatr Surg 1995;30: 277–281. Minevich E, Wacksman J, Lewis AG: Inguinal microsurgical varicocelectomy in the adolescent: Technique and preliminary results. J Urol 1998;159:1022–1024. Ziegler MM: Diagnosis of inguinal hernia and hydrocele. Pediatr Rev 1994;15:286–288.

C h Ap t e r

21

Introduction Definitions Pathophysiology Normal Breast Architecture Conditions Associated with Breast Development Mastalgia Discharge Breast Mass Breast Cancer Nipple Piercing

Evaluation Management Breast Self-Examination Reduction Mammoplasty Breast Augmentation

Introduction Serious breast disease is rare in adolescent females. Common presenting complaints are breast pain, nipple discharge, and the discovery of a mass. Because of heightened public awareness of breast cancer, even minimal breast symptoms may cause considerable anxiety in patients and families. However, benign disease dominates the differential diagnosis and dictates a unique protocol for care in the adolescent compared with the adult patient. Many breast specialists are not adequately experienced with the young patient or familiar with the data for this population. Their adult frame of reference can lead to inappropriately high assessment of risk, diagnostics, and surgery. This chapter will present an adolescentspecific outline for the evaluation and management of common breast symptoms, as well as how to address concerns about breast cancer.

146

Breast Disorders in Females Jill S. Huppert, MD, MPH Nichole Zidenberg, MD

Definitions Amastia: Absence of the breast and nipple. Amazia: Absence of the breast with presence of the nipple. Fibroadenoma: Benign solid tumors of the breast containing glandular and fibrous tissue. Galactorrhea: Spontaneous discharge of milk from the nipple without breastfeeding. Lobule: Cluster of ductules (i.e., alveoli) around a terminal end bud. Macromastia: Extreme bilateral hyperplasia of breast tissue. Mastalgia or Mastodynia: Pain in the breast; cyclical pain suggests fibrocystic changes. Mastitis: Inflammation of the breast, usually caused by infection. Morgagni tubercles: Elevations at the periphery of the areola where ducts from large sebaceous glands open. Polymastia: Accessory nipple(s) and breast tissue. Polythelia: Accessory nipple(s). Stroma: Adipose and fibrous tissue that comprises most of the non-lactating breast volume.

Pathophysiology Normal Breast Architecture The pre-pubertal breast consists of narrow, primitive ducts in the region of the nipple and areola. With puberty, estradiol stimulates branching of the ducts and the formation of terminal end buds which, in turn, form new branches called alveolar buds, ductules, or alveoli. The formation of about 11 ductules around the ­terminal end

Breast Disorders in Females 147



bud constitutes a Type 1 lobule, which appears within 2 years of menarche. With maturation, Type 2 lobules form (i.e., about 50 alveoli per lobule) and, with pregnancy, Type 3 lobules form (about 80 alveoli per lobule). Maximal proliferation of the ductal epithelium occurs in the presence of both estrogen and progesterone. Microscopically, it is manifested by the larger-sized ductules of the Type 1 lobule. The nulliparous breast consists primarily of Type 1 lobules and epithelial cells that are estrogen receptor (ER)-positive and progesterone receptor (PR)-positive. The parous breast of a reproductive-aged women is predominantly Type 3 lobules, and the pro­portion of ER-positive and PR-positive cells is 10 times lower than in the nulliparous adolescent. In the post-menopausal woman, there is regression of Types 2 and 3 lobules to a predominance of  Type 1 lobules. The Type 1 lobule is thought to be the site of origin for ductal carcinoma, explaining the higher risk of its development in nulliparous women.

Conditions Associated with Breast Development Pubertal development of the breast begins with the appearance of nodular, firm breast buds beneath the areola that may be tender or asymmetrical. In one series, 45% of females younger than 18 years who were referred for the evaluation of breast masses had asymmetrical breast buds associated with normal thelarche. Biopsy is not indicated in these young girls because it can cause irreversible damage to the developing breast bud with resulting hypoplasia or amazia. Polythelia, or accessory nipple(s), is the most common breast abnormality of adolescent males and females. The accessory nipples typically occur without underlying breast tissue and may be found anywhere along the milk line that runs from the axilla to groin. Rarely, it is associated with renal or other anomalies. An estimated 25% of adolescent females have idiopathic breast asymmetry that persists into adulthood. In most cases, it is mild and without associated anomalies. Unilateral amastia or severe hypoplasia, however, usually is associated with unilateral pectoral muscle hypoplasia and, less commonly, with unilateral anomalies of the upper limb. The cause is unknown, but evidence suggests fetal abnormalities in subclavian artery flow. Juvenile breast hypertrophy is the rapid, unilateral, or bilateral overgrowth of breast tissue in adolescent females, typically beginning shortly after thelarche. Extreme bilateral hyperplasia has been termed macromastia, or gigantomastia, and is exceedingly rare. However, breast hypertrophy and significant asymmetry are neither rare nor psychologically insignificant. Adolescents with these ­ conditions receive negative social attention and are at increased risk for low self-esteem, social isolation, and eating disorders.

Mastalgia Breast pain, or mastalgia, is a common complaint during adolescence and is usually associated with shifts in the hormonal stimulation of the breast. In most adolescents, mastalgia does not represent fibrocystic disease. Even in adult women, fibrocystic changes are an expected component of breast maturation and do not represent disease, pre-cancer, or cancer. Fibrocystic breast tissue does respond to hormonal flux and typically presents as tender breast nodularity, usually in the upper outer quadrant, that worsens premenstrually. Other etiologies for breast pain include cysts, mastitis, and candida infection of the nipples. In addition, irritation of the chest wall, costochondritis, and ­ ­myalgia can be misconstrued as arising from the breast. Box 21-1 outlines the usual management of patients with breast pain associated with hormonal fluctuation. Although the oral contraceptive has been shown to decrease mastalgia over time, new users commonly complain of transient breast tenderness. Other hormonal therapies, such as bromocriptine, danazol, and tamoxifen, have been shown to decrease breast pain in 66–75% of subjects but are associated with significant side effects and rarely are indicated for mastalgia in adolescents. The effectiveness of complementary and alternative therapies, such as vitamin E and evening primrose oil, remains unproven.

Discharge Nipple discharge is a common symptom during adolescence and is usually due to either ductal ectasia or galactorrhea. Ductal ectasia may cause a mass as well as discharge and is a benign finding in the developing breast, consisting of ductal dilation, periductal fibrosis, and inflammation. Galactorrhea, or the production of milk in a non-lactating female, is distinguishable from other causes of nipple discharge by its thin, milky character and tendency to involve both breasts. Most, but not all, patients with galactorrhea have hyperprolactinemia. Conditions associated with galactorrhea and ­hyperprolactinemia are listed in Table 21-1. The association of galactorrhea and amenorrhea is discussed in Chapter 22. Box 21-1  Management of Primary

Mastalgia

l l l l l l l

Reassurance Smoking cessation Avoidance of caffeine Low-fat diet Sports bra during exercise Naproxen sodium or ibuprofen Oral contraceptive

148 Adolescent Medicine: The Requisites in Pediatrics

Table 21-1 Conditions Associated with Galactorrhea and Elevated Prolactin Levels Condition Pregnancy Hypothalamic lesions Prolactin-secreting tumors Hypothyroidism Stress Chronic renal failure Local irritants Medications Antipsychotics (neuroleptics) Phenothiazines Thioxanthenes Butyrophenones Atypical antipsychotics Antidepressants Tricyclic antidepressants Monoamine oxidase inhibitors Antihypertensive medications Gastrointestinal medications Motility agents Anti-nausea Opiates and cocaine Estrogen Oral contraceptives

Example

Pituitary tumor, stalk compression Pituitary adenoma, microadenoma Recent surgery Chest wall trauma, stimulation

Chlorpromazine, thioridazine Thiothixene Haloperidol Risperidone, molindone Clomipramine, amitriptyline Pargyline1 Verapamil, methyldopa, reserpine Metoclopramide, domperidone Prochlorperazine Morphine (High dose) (Conflicting data—not seen with current formulations)

Not currently in use.

1

Intraductal papillomas are a rare cause of bloody or serosanguinous nipple discharge. Montgomery’s tubercles—small glands located at the outer aspect of the areola—may produce a nipple discharge that resolves spontaneously.

Breast Mass Retrospective chart reviews indicate that biopsies of breast masses in adolescents reveal fibroadenomas in 60–70%, fibrocystic changes in 15–20%, abscess/mastitis in 1–3%, and simple cysts in 1–3%. Fibroadenomas are benign solid tumors containing glandular and fibrous tissue that most commonly occur in adolescent and young adult women. Several longitudinal studies demonstrate that 40–60% of fibroadenomas regress spontaneously and that regression is more likely in adolescents than in older women, regardless of the size or number of lesions. The use of oral contraceptives appears to decrease the risk of fibroadenomas. As discussed previously in the section on mastalgia, fibrocystic changes are less common in adolescent than adult women. Simple cysts, arising from either obstruction of the lactiferous duct or an imbalance of fluid production and resorption, often resolve spontaneously. When persistent and painful, needle aspiration following ultrasound

usually relieves the symptoms. In the adolescent, cytology of the fluid is not warranted unless it is grossly bloody. Other etiologies such as juvenile hypertrophy, ductal ectasia, lymph nodes, accessory breast tissue, abscess, fat necrosis, papillomatosis, cystosarcoma phylloides, and metastatic cancer are seen in < 1% of cases (Table 21-2). Mastitis or breast abscess often follows minor skin trauma, is caused by skin flora, and is usually subareolar in location. Cystosarcoma phylloides is a rare tumor that tends to be large in size and to grow rapidly. Malignancy is rare, but the rate of growth warrants prompt excision for both diagnosis and treatment.

Breast Cancer Breast cancer is extremely rare in adolescents. The combined rate of primary breast cancer and metastatic malignancy from another site is 1 per million females under age 20 years and 12 per million females at ages 20–24 years. When malignancy does occur in the young breast, it is more likely to be metastatic than primary. The risk of primary breast cancer is increased in adolescents who have had malignancies at other sites and/or have received radiation therapy to the anterior chest at least 10 years

Table 21-2  Breast Masses in the Adolescent Female Benign Solid

Cystic

Fibroadenoma

Fibrocystic changes

Fibrocystic changes Mastitis

Simple cyst

Unilateral thelarche Lymph node Fat necrosis Macromastia (juvenile hypertrophy) Lipoma Hematoma Hamartoma Intraductal papilloma Juvenille papillomatosis Cystosarcoma phylloides (benign)

Duct ectasia

Abscess

Galactocele

Malignant

Primary: Lymphoma,   neuroblastoma, sarcoma,   rhabdomyosarcoma,   acute leukemia Metastatic disease Cystosarcoma phyllodes (malignant) Breast carcinoma

Breast Disorders in Females 149



earlier. As discussed further in the Management section, these adolescents may benefit from breast self­examination. The average woman in the United States surviving to age 72 years has an 11% lifetime risk of developing breast cancer. Family history of breast cancer in a first-degree relative increases this risk two- to three-fold, and the BRCA 1 or 2 gene carries a risk of 3.2% by age 30 years and 85% by age 70 years. Other factors associated with an increased risk of breast cancer in adulthood include smoking, alcohol use, obesity, adult weight gain, high intake of sweet foods, and a sedentary lifestyle. There is considerable confusion and anxiety regarding a potential association between oral contraceptive use and the development of breast cancer. A study of more than 4500 women demonstrated no increased risk of breast cancer for women who were past or current users of oral contraceptives compared with never-users. Two other studies demonstrated that a history of oral contraceptive use for at least 1 year decreased the risk of breast cancer by more than 70% in women with the BRCA 1 gene but had no effect on risk in women with the BRCA 2 gene. Although pregnancy appears to decrease the lifetime risk of breast cancer, there are no scientific data to ­support an association between abortion and breast

c­ ancer. A meta-analysis of 44,000 women from 16 countries participating in 53 studies concluded that history of an induced abortion did not increase the risk of breast ­cancer later in life.

Nipple Piercing Nipple piercing is a common practice among adolescent females and males. The 3–6 months required for healing is longer than that of other pierced sites. Complications include infection; bleeding and hematoma; allergic reaction to the ornament; keloid formation; and the potential transmission of hepatitis B, hepatitis C, and human immunodeficiency virus (HIV). Clinicians should educate patients regarding safer piercing strategies and should ensure immunization against hepatitis B and tetanus. Adolescents with metal allergies, bleeding disorders, valvular heart disease, keloids, diabetes mellitus, and ­immunosuppression should avoid piercing.

Evaluation Figure 21-1 outlines an approach to the evaluation of breast conditions in adolescent-aged patients. Regardless

Clinical history

Normal

Pain

Mass

Exam

Exam

Red nipple

Erythema, warmth, fever

Mass

?

No mass

Erythema, warmth, fever Dx = mastalgia

Reassurance, supportive measures

DX = yeast

Treat with topical antifungal

Dx = mastitis

Treat with antibiotics

No

U/S to confirm abscess

Reassurance

Yes No Repeat exam 5–8 wks

Yes

Antibiotics plus needle/drainage No suspicious findings: observe

Figure 21-1 Evaluation of breast conditions in adolescent females.

Resolve Persist U/S

Solid or cystic

150 Adolescent Medicine: The Requisites in Pediatrics

of the presenting complaint, the history begins with a discussion of the problem from the adolescent and parent perspectives and a complete medical history, including personal and family risks for cancer. An issue that seems minor to the clinician and parent may have a significant effect on the adolescent’s self-esteem and psychosocial function. An issue of relatively little concern to the adolescent, such as a breast nodule, may frighten the parent who considers any breast mass cancer until proven otherwise. Once the individual perspectives are understood, the evaluation can be adapted to reassure as well as to diagnose and plan management. The physical examination should include an assessment of the Tanner stages for breast and pubic hair development (see Chapter 1). A complete breast exam should include visual inspection and palpation of both breasts with the patient sitting as well as supine. The areola/nipple complex should be gently compressed to express discharge. The axillae should be palpated to detect lymphadenopathy. For patients with nipple discharge or galactorrhea, serum levels of prolactin and thyroid stimulating hormone (TSH) should be measured. A gram stain of the discharge can identify fat globules, which differentiates galactorrhea from other discharge. Adolescents who have galactorrhea without a breast mass and normal prolactin and TSH levels can be followed with supportive measures, such as a well-fitting bra and the avoidance of ­nipple stimulation. Mammography should not be performed in adolescents. The dense fibroglandular tissue of the adolescent breast results in poor image quality, high rates of falsepositive and false-negative readings, and the risks accompanying unnecessary surgery. Ultrasound can be used to differentiate solid lesions that can be followed without intervention from cysts or abscesses that warrant needle aspiration. Cytology of aspirated fluid is not warranted in adolescents unless the fluid is grossly bloody. Culture of the fluid is indicated in patients with mastitis or abscess, but antibiotics to cover skin flora are indicated prior to the final culture results. Adolescents with cystic or solid breast lesions who do not have other worrisome findings on history or physical examination may be followed ­without further evaluation over several menstrual cycles.

Management Breast surgery before the completion of puberty can deform the developing breast and should be avoided. Indications for surgery include the following: a breast mass that enlarges rapidly, has overlying skin changes, or occurs in a patient with a previous malignancy at another site; a breast abscess that has not responded to aspiration and antibiotics; and corrective surgery for breast

a­ nomalies that will not improve with maturation and are associated with physical or psychosocial distress. Specific issues that arise commonly during adolescence are­ discussed below.

Breast Self-Examination In the past, many experts recommended that adolescents be taught breast self-examinations to establish the health habit and promote an understanding of its importance in adulthood. However, there are no data to support breast self-examination during adolescence and there is concern that it may produce unnecessary anxiety, testing, and surgery. There is consensus in the literature that breast self-examination should be encouraged for all adolescents with a history of malignancy, adolescents who are at least 10 years post-radiation therapy to the chest, and adolescents 18–21 years of age whose mothers carry the BRCA 1 or BRCA 2 gene.

Reduction Mammoplasty Surgical removal of breast tissue, or reduction mammoplasty, is indicated for adolescents with juvenile breast hypertrophy or significant breast asymmetry. More than 75% of women who had reduction mammoplasty performed during adolescence report improved self-esteem and satisfaction with the procedure, even when surveyed several years postoperatively. In one study, 94% would recommend it to a teenage friend with a similar condition. Potential complications include postoperative pain, incisional separation, scarring, sensory loss, infection, difficulty with breastfeeding, and regrowth of breast tissue. The decision about whether and when to recommend reduction mammoplasty depends on the adolescent’s physical symptoms, psychosocial discomfort, pubertal stage, and cognitive maturation. The referring physician and plastic surgeon should be confident that the adolescent has realistic goals and fully understands the limitations and risks of breast surgery. Some experts recommend postponing surgery until the breast is fully matured with no change in breast size for at least 6–12 months.

Breast Augmentation Medical and social controversy surrounds breast augmentation during adolescence. The number of augmentation procedures performed in patients aged 18 years and younger has increased three-fold in 10 years. The U.S. Food and Drug Administration does not approve the use of breast implants prior to age 18 years, and the American Society for Plastic Surgery recommends that aesthetic breast surgery should be reserved for patients who are physically and emotionally mature and who are not ­seeking surgery to meet peer or parent expectations.

Breast Disorders in Females 151



The adolescent who requests augmentation and her parent(s) should be counseled about the timing of the procedure as well as the risks, restrictions, recovery time, and potential impact of the surgery on the sensitivity of future mammography screening. It is also important to note, however, that there is no evidence that breast implants increase the risk of breast cancer or difficulty with breastfeeding.

 l l

l

l

l

l

l

l

Major Points

b

Breast cancer is exceedingly rare in adolescents. Breast self-examination is not recommended for most adolescents. It is recommended for adolescents with past or current malignancy at other sites, adolescents who had chest radiation 10 or more years earlier, and adolescent 18–21 years of age with a maternal history of the BRCA 1 or 2 gene. Observation and noninvasive testing are indicated for most adolescent breast complaints. Breast pain (mastalgia) in most patients is hormonally related, benign, and self-limited. Fibroadenomas are the most common solid breast lesions in adolescents. They are benign, often regress spontaneously, and do not require removal unless disfiguring or enlarging. Galactorrhea can be secondary to a variety of medications or, rarely, pituitary adenomas. Breast surgery before the completion of puberty should be avoided in females due to the potential for iatrogenic damage to the developing breast tissue. Breast cancer prevention may include physical exercise and avoidance of obesity, tobacco, and alcohol use.

Bibliography

Gateley CA, Miers M, Mansel RE, et al.: Drug treatments for mastalgia: 17 years experience in the Cardiff Mastalgia Clinic. J R Soc Med 1992;85:12–15. Goyal A, Mansel RE: Iatrogenic injury to the breast bud causing breast hypoplasia. Postgrad Med J 2003;79:235–236. Hindle WH, Arias RD, Florentine B, et al.: Lack of utility in clin­ ical practice of cytologic examination of nonbloody cyst fluid from palpable breast cysts. Am J Obstet Gynecol 2000;182: 1300–1305. Lee MC, Lehman JA, Jr, Tantri MD, et al.: Bilateral reduction mammoplasty in an adolescent population: Adolescent bilateral reduction mammoplasty. J Craniofac Surg 2003;14:691–695. Marchbanks PA, McDonald JA, Wilson HG, et al.: Oral con­traceptives and the risk of breast cancer. N Engl J Med 2002;346:2025–2032. Marcus PM, Newman B, Millikan RC, et al.: The associations of adolescent cigarette smoking, alcoholic beverage consumption, environmental tobacco smoke, and ionizing radiation with subsequent breast cancer risk (United States). Cancer Causes Control 2000;11:271–278. McGrath MH, Mukerji S: Plastic surgery and the teenage patient. J Pediatr Adolesc Gynecol 2000;13:105–118. McGrath MH, Schooler WG: Elective plastic surgical procedures in adolescence. Adolesc Med Clin 2004;15:487–502. Milne RL, Knight JA, John EM, et al.: Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations. Cancer Epidemiol Biomarkers Prev 2005;14:350–356. Molitch ME: Medication-induced hyperprolactinemia. Mayo Clin Proc 2005;80:1050–1057. Narod SA, Dube MP, Klijn J, et al.: Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst 2002;94:1773–1779. Neinstein LS, Atkinson J, Diament M: Prevalence and longitu­ dinal study of breast masses in adolescents. J Adolesc Health 1993;14:277–281.

American Society of Plastic Surgeons: 2005 Cosmetic Surgery Age Distribution (18 or Younger). Arlington Heights, IL, American Society of Plastic Surgeons, 2006. Available from: http://www.plasticsurgery.org/public_education/2004 Statistics. cfm. Accessed May 17, 2007.

Rogerson T, Ingram D, Sterrett G, et al.: Areolar discharge and peri-areolar breast cysts in adolescent females. Breast 2002;11:181–184.

American Society of Plastic Surgeons: Policy Statement: Breast Augmentation in Teenagers. Arlington Heights, IL, American Society of Plastic Surgeons, 2004. Available from: http://www. plasticsurgery.org/news_room/press_releases/Teens-BreastAugmentation-Policy.cfm. Accessed May 17, 2007.

Versluijs-Ossewaarde FN, Roumen RM, Goris RJ: Subareolar breast abscesses: Characteristics and results of surgical treatment. Breast J 2005;11:179–182.

Berna-Serna JD, Madrigal M, Berna-Serna JD: Percutaneous management of breast abscesses. An experience of 39 cases. Ultrasound Med Biol 2004;30:1–6. Bundred N: Breast pain. Clin Evid 2004;11:2334–2343.

Simmons PS: Breast disorders in adolescent females. Curr Opin Obstet Gynecol 2001;13:459–461.

Weinstein SP, Conant EF, Orel SG, et al.: Spectrum of US findings in pediatric and adolescent patients with palpable breast masses. Radiographics 2000;20:1613–1621. West KW, Rescorla FJ, Scherer LR 3rd, et al.: Diagnosis and treat­ ment of symptomatic breast masses in the pediatric population. J Pediatr Surg 1995;30:182–186; discussion 186–187.

22

C h A p t e r

Introduction Normal Menstrual Cycle Amenorrhea Pathophysiology Evaluation Management

Abnormal Uterine Bleeding Epidemiology Pathophysiology Evaluation Management

Primary Dysmenorrhea Definitions Epidemiology Pathophysiology Evaluation Management

Premenstrual Syndrome Definitions Epidemiology Pathophysiology Evaluation Management

Introduction Menstrual problems affect at least 75% of females at some time during the adolescent years. Although oligomenorrhea or amenorrhea, abnormal uterine bleeding, dysmenorrhea, and premenstrual syndrome are common throughout reproductive life, the predominant causes of these problems change with maturation. This chapter begins with a review of the normal menstrual cycle during adolescence, followed by discussions of the epidemiology, pathophysiology, evalua152

Menstrual Disorders Paula K. Braverman, MD Lesley L. Breech, MD

tion, and management of each of these clinical issues in adolescent-aged patients.

Normal Menstrual Cycle The median ages of menarche in the United States are 12.4 years across all races/ethnicities, 12.1 years for black females, 12.3 years for Hispanic females, and 12.6 years for white females. Menarche typically occurs 2 to 3 years after thelarche (i.e., breast budding), at a Tanner Stage of 4 for breast development. Girls with earlier thelarche tend to have a longer interval to menarche than girls with later thelarche. By age 15 years, however, 98% of girls in the United States achieve menarche. The interval from menarche to the second episode of menstrual bleeding varies widely across individuals. By 1 year following menarche, 90% of girls have menstrual cycles ranging from 21–45 days and menstrual flow ranging from 2–7 days. With maturation, the proportion of cycles that are ovulatory increases and cycle duration shortens. By the third year after menarche, 60–80% of cycles are of 21–34 days duration. The individual’s normal cycle length is established around the sixth gynecological year. Quantifying menstrual blood loss based on an adolescent’s history is difficult and inexact. The number of pads or tampons used per day and the frequency of pad/tampon changes depend on the adolescent’s familiarity or comfort with menstrual hygiene products, types and brands of products used, and personal fastidiousness. Most adolescents report three to six changes daily, although external constraints such as school rules and limited time between classes may make menstrual hygiene more problematic for adolescents than adults. Menstrual flow requiring changes of menstrual products every 1 or 2 hours is considered excessive, particularly when associated with flow of more than 7 days duration.

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Amenorrhea Primary amenorrhea is defined as the absence of menarche by that age at which it is achieved by 95–98% of the population. Because 95% of girls in the United States reach menarche by age 14.5 years and 98% by age 15 years, a conservative and commonly used cut-point for defining primary amenorrhea is 15 years. The absence of breast development or pubic hair by age 13 years in girls signals a likely delay in menarche and should trigger an evaluation of pubertal delay (Chapter 10) well before the evaluation of primary amenorrhea. In the adolescent who has achieved menarche, secondary amenorrhea is defined as the absence of menses for at least three consecutive cycles or for 6 months if regular cycles have not been established.

Box 22-1  Differential Diagnosis of

Amenorrhea

Hypothalamic Causes l l l l l l l

GnRH deficiency Chronic/systemic illness Stress Excessive exercise Malnutrition, low body fat Tumor Thyroid disease

Pituitary Causes l l l

Absence of LH, FSH Destruction of pituitary gland Tumor

Ovarian Causes

Pathophysiology Many organizational systems have been proposed to help categorize the causes of primary and secondary amenorrhea. The system utilized below identifies the cause as originating in the hypothalamus, pituitary, ovary, or outflow tract (Box 22-1). Hypothalamic causes of amenorrhea result in abnormal secretion of gonadotropin-releasing hormone (GnRH) which, in turn, affects pituitary secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and ovarian secretion of estrogen and progesterone. The associated menstrual cycle abnormalities range from mild luteal phase defects to severe hypoestrogenemia. Hypothalamic amenorrhea is much more likely to reflect functional suppression of GnRH secretion than a structural defect in the anatomy of the hypothalamus. Functional hypothalamic amenorrhea may be caused by weight loss, strenuous exercise, acute or chronic illness, and emotional upset. All of these conditions, whether physical or emotional, produce physiological stress with increases in hypothalamic secretion of corticotropin-releasing hormone (CRH), which in turn increases corticotropin (ACTH) secretion by the anterior pituitary and corticosteroids by the adrenal gland. CRH also suppresses GnRH secretion, perhaps through an increase in central nervous system levels of dopamine or endogenous opioids. As a result of the GnRH suppression, pituitary secretion of LH decreases and ovulation ceases. Ovulation and normal menstrual function generally reflect a positive energy balance between intake and expenditure and an energy reserve in the form of body fat. When depleted energy reserves threaten the basic metabolic processes required for survival, anovulation protects the female from the added energy burden of pregnancy. Studies of athletes have shown there is a significant correlation between strenuous exercise and

l l l l

Gonadal dysgenesis Destruction of ovarian tissue Polycystic ovary syndrome Ovarian tumor

Outflow Tract Anomalies l l l

Imperforate hymen Transverse vaginal septum Agenesis of uterus, vagina

Other Causes l l l l

Pregnancy Hormonal contraception Congenital adrenal hyperplasia Adrenal tumor

­ isruption of the menstrual cycle. Up to two-thirds of d runners have been found to have anovulation or short luteal phase cycles. Exercise has also been associated with a decrease in thyroxine and increases in growth hormone (GH), testosterone, ACTH, adrenal steroids, endorphins, and melatonin. Evidence suggests that the negative energy balance of excessive exercise may be due to an increase in insulin-like growth factor binding protein-1 (IGFBP-1) and a decrease in insulin-like growth factor (IGF) activity, which contribute to suppression of GnRH. Body fat is a more important determinant of ovulation than body weight, with 22% the estimated minimum required to maintain regular ovulatory cycles in most adults. The average 18% body fat at menarche may contribute to the higher proportion of anovulatory cycles during the early gynecological years than thereafter. The mechanism underlying the association between body fat and ovulation appears to be leptin, which is produced in body fat and signals the brain that there are adequate

154 Adolescent Medicine: The Requisites in Pediatrics

energy stores. With weight loss and a decrease in body fat, there is a fall in leptin levels leading to suppression of gonadotropin secretion. Chronic suppression of the hypothalamic–pituitary axis, as in patients with anorexia nervosa or persistent, excessive exercise, is associated with severe hypoestrogenemia. In addition to anovulation, the very low estrogen levels result in an atrophic endometrium and a complete absence of breakthrough bleeding. Bone mineralization peaks during adolescence and slows or halts in the absence of estrogen. The resulting plateau in bone density may place the young woman at lifelong risk of osteoporosis and fracture. Structural hypothalamic amenorrhea most commonly is due to Kallman syndrome or congenital GnRH deficiency (Chapter 10). Other causes include hypothalamic tumors, irradiation of the central nervous system, and hypothyroidism. The menstrual abnormalities associated with hypothyroidism are due to increased hypothalamic secretion of thyroid-releasing hormone (TRH), increased prolactin, and negative feedback on GnRH. Pituitary causes of amenorrhea include tumors, infarction, surgery, radiation, cysts, tuberculosis, sarcoidosis, replacement by fatty tissue, and rare inherited deficiencies of LH and FSH. Pituitary adenomas account for up to one-third of cases of secondary amenorrhea and, of these, half are prolactin-secreting (i.e., prolactinoma). Large prolactinomas can produce visual field cuts and headache. Most, however, are small microadenomas that present as galactorrhea and/or amenorrhea without a mass effect. Other, less common pituitary tumors are craniopharyngiomas, meningiomas, gliomas, chordomas, and metastases from other sites. Tumors, infiltrative processes, and cysts of the pituitary or nearby tissue can decrease FSH and LH secretion by destruction of pituitary tissue and/or compression of the pituitary stalk with decreased delivery of GnRH from the hypothalamus to the pituitary. Compression can also disrupt dopaminergic regulation, resulting in hyperprolactinemia and feedback inhibition of GnRH secretion. In some cases, hyperprolactinemia presents as galactorrhea with relatively normal menses, whereas in others it presents as amenorrhea. Pituitary tumors associated with Cushing disease, hyperthyroidism, and acromegaly can cause amenorrhea but do so within a spectrum of other signs and symptoms. Sheehan syndrome, or pituitary apoplexy, is a rare postpartum complication in which hemorrhagic shock causes infarction and necrosis of the pituitary gland, with subsequent deficiencies of one or more pituitary ­hormones. Ovarian causes of amenorrhea present as hypergonadotropic hypogonadism (Chapter 10) and include gonadal dysgenesis or agenesis, premature ovarian failure, and resistant ovaries. Gonadal dysgenesis and premature ovarian failure account for 30–40% and 10–28% of

­ rimary amenorrhea, respectively. Gonadal dysgenesis, p or Turner syndrome (Chapter 10), presents in its pure, 45,X form in 60% of cases and as genetic mosaicism in 40% of cases. Most patients with Turner syndrome have nonfunctioning ovarian streaks, pubertal delay, and primary amenorrhea. Although unusual, some patients with mosaic Turner syndrome produce sufficient estrogen to support pubertal development and menses. Rarely, a patient with mosaic Turner syndrome can become pregnant. However, even in those patients who do have functioning ovarian tissue, most experience premature menopause with accelerated follicular atresia. Premature ovarian failure, defined as menopause before age 40 years, affects 1% of women. It presents with primary or secondary amenorrhea and elevated serum levels of LH and FSH due to hypoestrogenemia and the lack of negative feedback on the hypothalamic–pituitary axis. Although most cases are idiopathic, known causes of premature ovarian failure include radiation to the pelvis, chemotherapy, infection, trauma, and autoimmune disease. Ovarian failure is less likely in younger than in older women who are exposed to radiation or chemotherapy, perhaps because of younger and more numerous oocytes. Alkylating chemotherapeutic agents are particularly toxic to the ovary, and the use of multiple agents increases the chances for ovarian failure. Autoimmune diseases such as thyroiditis, adrenal insufficiency, and hypoparathyroidism have been associated with ovarian antibodies and lymphocytic infiltration into developing follicles. In galactosemia, metabolites of galactose impair germ cell migration to the genital ridge, resulting in premature ovarian failure. Finally, patients who are Fragile X carriers are at risk for ­premature ovarian failure. It is important to recognize that elevated gonadotropins may not represent ovarian failure. Pituitary adenomas that secrete FSH and LH typically do not present with amenorrhea but, rather, with headaches and visual disturbances related to tumor growth. Patients with resistant ovaries have mutations of the gonadotropin receptor, resulting in present but unresponsive ovarian follicles and elevated serum gonadotropins. Late-onset congenital adrenal hyperplasia due to deficiency of 17hydroxylase is manifested as amenorrhea and elevated gonadotropins in the presence of ovarian follicles (Chapter 23). Outflow tract anomalies fall into four categories: agenesis/hypoplasia, abnormal canalization, duplication of structures, and the presence of a septum within the uterine cavity or vaginal canal. Most isolated abnormalities of the Müllerian duct and urogenital sinus are polygenic, but single gene mutations have been identified for a few rare syndromes. The clinical severity of outflow tract anomalies varies widely. A study of fertile women having laparoscopic

Menstrual Disorders 155



bilateral tubal ligation performed for contraception revealed that 3% had previously unrecognized Müllerian tract anomalies. At the other extreme is Müllerian agenesis, or Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, which occurs in approximately 1 per 5000 female births. MRKH syndrome is the congenital absence of the proximal vagina and, in 90% of cases, the cervix and uterus. Those cases in which a normal or rudimentary uterus is present typically have functioning endometrium with obstruction to flow due to the abnormal vaginal canal. Imperforate hymen is probably the most common obstructive anomaly of the female reproductive tract. Familial occurrences of imperforate hymen have been reported, but most cases are isolated events. The adolescent patient with an imperforate hymen may be asymptomatic before the accumulation of concealed menstrual flow or may present with recurrent bouts of cyclical abdominal pelvic pain. A bluish, bulging hymen and a vagina distended with blood may be found on genital inspection and recto-abdominal palpation. In some cases, the vagina may be extremely large, and the condition may result in back pain, pain with defecation, nausea and vomiting, and/or difficulty with urination. In extreme cases, hydronephrosis due to mechanical obstruction of the ureters from the grossly enlarged vagina can occur. Transverse vaginal septa are believed to arise from a failure in fusion and/or canalization of the urogenital sinus and Müllerian ducts. Approximately 46% of vaginal septa occur in the upper vagina, 40% in the middle vagina, and 14% in the lower vagina. On speculum examination, the vagina is a short, blind pouch. The septa are usually less than 1 cm thick and may extend completely or partially from one vaginal sidewall to the other. Although transverse vaginal septa often have small central or eccentric perforations, hematocolpos remains a common presenting finding. Rarely, pyohematocolpos may be caused by ascending infection through the small perforation. Androgen insensitivity syndrome typically presents as primary amenorrhea in an adolescent who is phenotypically female and genetically male (46X,Y). Testes are present but do not descend completely and are at increased risk for malignancy. Müllerian-inhibiting substance is produced, which prevents the development of the female internal reproductive structures, including the upper vagina, cervix, and uterus. Testosterone is also produced but there is end-organ insensitivity to its effects with abnormal negative feedback and high estrogen levels due to peripheral conversion of the testosterone. Breast development is normal, pubic and axillary hair is scant, the vagina is short, and the cervix and uterus are absent. Complete androgen insensitivity is usually diagnosed during puberty when a well-developed young woman presents with amenorrhea.

Hyperandrogenism as a cause of amenorrhea or oligomenorrhea is discussed in Chapter 23. Conditions associated with hyperandrogenism include polycystic ovary syndrome (PCOS), ovarian or adrenal tumors that produce androgens, congenital adrenal hyperplasia, and Cushing disease. PCOS is the most common endocrine disorder in women of reproductive age and accounts for more than 90% of adolescent hyperandrogenism. Lateonset congenital adrenal hyperplasia (CAH), or 21hydroxylase deficiency, is an autosomal recessive disorder that typically presents during adolescence as amenorrhea or oligomenorrhea, hirsutism, and often virilization. Androgen-producing tumors are rare in adolescents but should remain in the differential diagnosis, especially in cases of amenorrhea associated with the rapid onset of hirsutism or virilization.

Evaluation The evaluation of an adolescent with amenorrhea begins with a thorough developmental and sexual history. The history should identify the ages of thelarche (i.e., onset of breast development), pubarche (i.e., onset of pubic hair development), and menarche; menstrual pattern; timing of first and last sexual intercourse; height and weight progression along established growth curves; eating and exercise ­ patterns; weight fluctuations; signs of hyperandrogenism; galactorrhea; pelvic pain; known genitourinary anomalies; and history of chronic illness. The physical examination should include the stages of breast and pubic hair development; the determination of body mass index (BMI) from the height and weight; skin examination for acne and hirsutism; ophthalmological examination; thyroid palpation; breast examination for galactorrhea; abdominal examination for masses; and pelvic examination for hymenal patency (i.e., insertion of a moist cotton swab into the vagina and/or bimanual examination); mucosal estrogenization; clitoral size; and outflow tract anatomy. A well-estrogenized mucosa should appear pink and moist, as compared with the red, thin mucosa of hypoestrogenemia. Patients who cannot tolerate bimanual examination or recto-vaginal examination and those in whom the examinations are inconclusive should have pelvic ultrasonography performed to identify developmental anomalies and/or genital tract obstruction. Ultrasound also allows measurement of the endometrial stripe, which is an index of estrogen stimulation of the endometrium, and identification of ovarian cysts or masses (Chapter 23). Ultrasound can be performed by transabdominal, transvaginal, and/or transperineal approaches. The latter can be helpful in young adolescents who cannot tolerate the transvaginal study. Magnetic resonance

156 Adolescent Medicine: The Requisites in Pediatrics

imaging (MRI) of the pelvis and/or abdomen is an excellent modality for further defining the presence of a vaginal septum, uterine remnant, streak gonads, and renal anomalies. MRI of the sella with and without contrast is the preferred modality for evaluating a suspected prolactinoma. Nearly all adolescents with primary or secondary amenorrhea warrant a qualitative test for human chorionic gonadotropin (HCG) to exclude pregnancy, even if sexual activity is denied, and measurement of serum prolactin and TSH levels. Signs of hyperandrogenism on physical examination should be explored with measurement of serum free and total testosterone, dehydroepiandrosterone-sulfate (DHEAS), FSH, LH, and perhaps 17-hydroxyprogesterone (Chapter 23). Adolescents with suspected but undiagnosed systemic illness should have a complete blood count, erythrocyte sedimentation rate, serum electrolytes, glucose, blood urea nitrogen (BUN), creatinine, liver function tests, total protein, albumen, and TSH. Serum FSH and LH levels will help differentiate hyperfrom hypogonadotropic hypogonadism (Chapter 10). Elevated levels in a patient with primary amenorrhea and no history of radiation, chemotherapy, or autoimmune disease suggest gonadal dysgenesis and should trigger chromosomal analysis. If chromosomes are normal, serum levels of anti-ovarian antibodies should be measured. Low levels of FSH and LH in a patient with primary or secondary amenorrhea indicate hypogonadotropic hypogonadism due to decreased function at the hypothalamic or pituitary level. If there is no evidence of underlying systemic illness or other endocrine disorder,evaluation for Kallman syndrome should be pursued by formal olfactory testing, genetic and endocrine consultation, and head MRI. As noted in Chapter 10, the assessment of pituitary function in an adolescent with primary amenorrhea in the setting of delayed puberty can be particularly difficult. Low or normal levels of serum GH and its mediators, IGF-1 and IGFBP-3, may reflect GH deficiency, malnutrition, low body weight, or constitutional delay of puberty. In adolescents with severe hypogonadotropic hypogonadism, GnRH stimulation testing by an endocrinologist can help determine whether anterior pituitary function is appropriate for the level of pubertal development.

Management The management of primary or secondary amenorrhea depends on the adolescent’s physical and psychosocial maturation as well as the underlying pathology. The major decisions are about hormonal therapy in patients with hypothalamic, pituitary, and ovarian causes, and about surgery in patients with outflow tract anomalies.

Hormonal therapy is indicated for all adolescents with ovarian failure. Those with primary amenorrhea who are pre-pubertal or in early puberty should be managed with low-dose estrogen replacement to stimulate maturation, followed by maintenance estrogen and progesterone, usually in the form of combination oral contraceptive pills (OCPs) containing 20–30  mcg estradiol or equivalent. Patients with secondary amenorrhea due to ovarian failure do not require titration of the estrogen dose and can begin maintenance therapy with low-dose OCPs. Adolescents with primary or secondary amenorrhea due to hypothalamic suppression can be challenged with oral progesterone 10 mg daily for 5 days. Withdrawal bleeding in response to the progesterone challenge indicates an intact outflow tract that has been primed by estrogen. The adolescent with persistent amenorrhea who responds to the challenge should repeat the 5-day course every 3 months to prevent chronic endometrial hyperplasia, which is a risk factor for endometrial cancer. The adolescent who does not respond to the challenge either has insufficient estrogen to induce a proliferative endometrium or has an outflow tract abnormality. The most common dilemma in the management of adolescents with amenorrhea is the use of hormone replacement therapy (HRT) in those with functional suppression of GnRH secretion. Although some studies suggest that bone density in adolescent athletes with hypothalamic amenorrhea may be protected by HRT with combined estrogen-progestin OCPs, current evidence does not support its use in adolescents with amenorrhea due to anorexia nervosa. Management should instead focus on weight gain and the maintenance of sufficient body fat to support menses (Chapter 35). Patients with amenorrhea due to medication-induced hyperprolactinemia usually can be managed conservatively, with continuation of the responsible medication if it is considered important for overall physical and psychosocial health. Serum prolactin levels < 100 ng/ml can be monitored every 3 to 6 months, whereas those over 100 ng/dl generally warrant further evaluation with either head MRI or discontinuation of the medication responsible for the increase. Levels of 100–200 ng/dl in patients who are not on medications associated with hyperprolactinemia usually indicate pituitary microadenomas that do not require treatment unless breast discomfort develops or the patient wishes to conceive. In these cases, the usual treatment is a dopamine agonist such as bromocriptine. Levels > 200 ng/dl are associated with pituitary adenomas that are likely to produce other symptoms, such as headache or visual field cuts. Surgery, often with adjunctive radiation therapy, is indicated for these patients. Surgery is indicated to correct imperforate hymen, transverse vaginal septum, and some cases of Müllerian aplasia. The correction of imperforate hymen can be

AU7

Menstrual Disorders 157



­ erformed at any age but is often delayed until early p puberty when the estrogen effect on the mucosa facilitates a good repair. Puncture of an imperforate hymen without definitive repair can result in bacterial infection of an inadequately drained fluid collection and should be avoided. The level and thickness of a transverse vaginal septum should be determined by MRI prior to surgery to help plan the procedure. The treatment of Müllerian aplasia begins with patient and family counseling about the cause and consequences of the anomaly. First and foremost is reassurance about female gender, both genetically and phenotypically. Although nonsurgical and surgical options exist for creating a vaginal canal, cervical and uterine dysgenesis is incompatible with successful pregnancy. In general, all techniques to establish a vagina should be delayed until mid to late adolescence when the patient can share in the decision about whether, when, and how to proceed. The nonsurgical method is considered first-line therapy and involves the use of vaginal dilators to apply progressive pressure against the vaginal dimple with gradual invagination of the mucosa. Recent studies demonstrate that 85– 90% of patients achieve a functional vagina with this method. For those patients in whom dilators are unsuccessful, surgery can be considered. However, the patient and family must understand that most surgical interventions require the postoperative utilization of dilators.

Box 22-2  Differential Diagnosis of

Abnormal Uterine Bleeding

Outflow Tract l l l l l l l

Trauma Foreign body Tumor Cervical polyp Uterine myoma Intrauterine device Uterine carcinoma

Ovarian Causes l l

Tumor Cyst

Anovulation l l l l l

Pituitary abnormalities Hypothalamic abnormalities Immaturity of the hypothalamic–pituitary axis Androgen excess Thyroid disease

Hematological Conditions l l l l

Thrombocytopenia Clotting disorders Platelet disorders Anticoagulant medications

Pregnancy

Abnormal Uterine Bleeding

l l

Abnormal uterine bleeding refers to the prolonged, acyclical, or heavy flow of blood and/or tissue from the endometrial cavity. Although most vaginal bleeding is of uterine origin, other causes should be considered, such as cervicovaginal trauma or mass (Box 22-2). When there is no identifiable structural, infectious, or hemostatic cause, the term dysfunctional uterine bleeding (DUB) applies. During early adolescence, most abnormal uterine bleeding meets the definition of DUB and reflects the irregular endometrial sloughing that accompanies anovulatory cycles. Abnormal uterine bleeding typically is described in terms of its duration, quantity, and the interval between bleeding episodes. Menorrhagia refers to bleeding that lasts > 7 days or is > 80 ml in quantity. Menometrorrhagia is heavy, prolonged bleeding that occurs at irregular intervals. Polymenorrhea occurs at regular but short intervals of < 21 days.

Epidemiology Most abnormal uterine bleeding during adolescence is DUB associated with anovulatory cycles. Less common causes include pregnancy, hormonal contraception, pelvic inflammatory disease (PID), bleeding disorders, hypo-

l

Ectopic Molar Miscarriage

Infection l l

Sexually transmitted infections Pelvic inflammatory disease

Hormonal Contraception

or hyperthyroidism, PCOS, trauma, and congenital anomalies of the outflow tract. Unlike adults, endometrial cancer is an extremely rare cause of abnormal uterine bleeding in adolescents. A study of girls presenting with menorrhagia at menarche revealed that 45% had systemic bleeding dyscrasias. Platelet function disorders, including von Willebrand disease, were particularly common and probably are under-recognized in young adolescents with menorrhagia. Although von Willebrand disease is considered the most common inherited bleeding abnormality among females, with an overall prevalence of 1.3% in a heterogeneous population of U.S. children and adolescents, several studies suggest that other platelet function disorders may be responsible for many cases of unexplained menorrhagia. There is some evidence that

158 Adolescent Medicine: The Requisites in Pediatrics

menorrhagia associated with platelet dysfunction is more common in black than white females.

Pathophysiology Anovulatory DUB in most adolescents is due to delayed maturation of the normal negative feedback mechanisms along the hypothalamic–pituitary–ovarian axis. The gradual rise in estrogen does not suppress FSH secretion, resulting in ongoing estrogen secretion by the ovaries and endometrial proliferation in response to the estrogen. In the absence of progesterone, which normally is increased in the luteal phase of the cycle, the thickening endometrium becomes increasingly unstable and disorganized shedding begins. Although immaturity accounts for most DUB during the first 1–2 years following menarche, it is unlikely beyond this point. Other causes of anovulation, such as PCOS, should always be considered if the DUB persists. Pregnancy is always in the differential diagnosis of abnormal uterine bleeding, and a qualitative urine pregnancy test should be performed in nearly all patients. Consultation with an obstetrician is recommended for any pregnant patient who is bleeding and is essential if the bleeding is associated with abdominal pain or hemodynamic instability. The differential diagnosis includes threatened or spontaneous abortion, ectopic pregnancy, PID, and gestational trophoblastic disease. von Willebrand disease is highly variable in severity and age at diagnosis. In many cases, menorrhagia at menarche is the first manifestation. Normally, platelets adhere to damaged blood vessels in a process mediated by the binding of von Willebrand factor (vWF) to a glycoprotein complex on the platelet membrane. In von Willebrand disease, underproduction or dysfunction of the vWF component of the Factor VIII molecule is associated with abnormal platelet adhesion at sites of vascular injury, reduced Factor VIII levels, and/or qualitative defects in Factor VIII activity. Patients with von Willebrand disease tend to have predominantly quantitative (Types I and III) or qualitative (Type II) defects of vWF, with Type I accounting for 70% of cases.

Evaluation The evaluation of an adolescent with abnormal uterine bleeding should begin with characterization of the bleeding pattern. Specific information should include age at menarche; cycle length (i.e., day 1 of bleeding to day 1 of next bleeding episode), duration of bleeding; and quantity of bleeding (i.e., number of saturated tampons or sanitary napkins per 24 hours). Other information on history should include age at onset of sexual activity, history of sexually transmitted infections (STIs), condom use, new sexual partners within the past 3

months, ­contraception, past history of nonvaginal bleeding or bruising, family history of bleeding disorders, and current ­medications. The physical examination should focus, first and foremost, on establishing hemodynamic stability through the evaluation of supine, sitting, and standing blood pressure and heart rate. Mucous membranes and skin should be examined for pallor, petechiae, ecchymoses, hirsutism, acne, and acanthosis nigricans. Lymphadenopathy and hepatosplenomegaly should be noted, and a new flow murmur on cardiac examination might suggest anemia. External genitalia should be examined for clitoromegaly, congenital anomalies of the introitus, and evidence of trauma. If DUB is likely and the patient is not sexually active, speculum examination is usually unnecessary. In other cases, however, it should be performed to inspect the cervix and vaginal canal and to collect samples for STI testing. Pelvic ultrasonography is often performed to delineate anatomy when a structural anomaly is suspected, to assess the thickness of the endometrial stripe, to determine whether a pregnancy is intrauterine, or to determine whether hematocolpos or a uterine clot is present. Even when DUB has been heavy and prolonged, a thickened endometrial stripe is usually visualized. A uterine clot suggests that distention of the uterine cavity is interfering with myometrial contraction and hemostasis. If the cause of abnormal bleeding remains uncertain, laboratory testing should include pregnancy testing (i.e., qualitative urine human chorionic gonadotropin [HCG]); STI testing of sexually active patients; measurement of serum TSH level and often serum androgen levels; CBC with platelet count; and prothrombin time and partial thromboplastin time. For patients in whom von Wille­ brand disease is suspected, the following laboratory studies should be ordered: Factor VIII activity, vWF antigen level, ristocetin cofactor activity, and multimeric analysis. The Platelet Function Analyzer (PFA-100), which is now available in many institutions, screens for acquired platelet disorders (e.g., aspirin-induced), von Willebrand disease, and some of the more complex inherited causes of platelet dysfunction. Tests of platelet aggregation represent the next level of evaluation but are laborious, costly, and not readily available in many institutions. In addition, interpretation of the results can be difficult because they are affected by hemolysis, lipemia, thrombocytopenia, and certain medications.

Management When there is an identifiable cause for abnormal uterine bleeding, such as PID, that problem obviously should be treated. The more difficult management decisions pertain to DUB and patients with bleeding dyscrasias. In these situations, hemodynamic status and hemoglobin level

Menstrual Disorders 159



Box 22-3  Management of Dysfunctional

Uterine Bleeding (DUB)

Mild: Hemodynamic Stability and Hemoglobin > 11 g/dl l l l l

Menstrual calendar. Iron supplementation. Consider combined OCP. Re-evaluate in 1–3 months.

Moderate: Hemodynamic Stability and Hemoglobin > 9 g/dl l l l

l

Menstrual calendar. Iron supplementation. Combined OCP containing ≥ 30 mcg ethinyl estradiol, one tablet every 6 hours until bleeding stops or up to 4 days, followed by taper to one tablet every 8 hours for 2–3 days, one tablet every 12 hours for 2 days, one tablet (i.e., active hormone tablet in packet, not placebo-week tablet) daily for 2–3 weeks. Then discontinue pills for 1 week to allow withdrawal bleed, followed by OCP cycles for 3–6 months. Re-evaluate in 1–3 months.

Severe: Hemodynamic Instability and Hemoglobin < 9 g/dl l

l l

l l

Hospitalization for intravenous fluids and/or transfusion. Iron supplementation. Combined OCP, as noted above. If bleeding does not slow significantly with two doses, add the following to the oral contraceptive regimen: conjugated estrogen 25 mg intravenously every 4–6 hours until bleeding stops or up to 4 doses. Dilatation and curettage if bleeding persists. Combined OCP cycles for 3–6 months.

often dictate treatment (Box 22-3). It is very important to note that the management of abnormal uterine bleeding in adolescents is quite different than in older adults. Unlike adults in whom persistent or uncontrolled uterine bleeding commonly leads to dilatation and curettage (D&C), this is rarely required in adolescents and should be considered only when the options, discussed later, fail. The stable adolescent with mild DUB and a normal hemoglobin level can be observed without treatment. The patient should record bleeding on a menstrual calendar, call immediately if flow increases or new symptoms develop, and schedule a follow-up visit within 1–3 months if bleeding stops or remains mild and intermittent. Hormonal therapy with a combined estrogen-progestin OCP can be initiated in those adolescents who are troubled by the bleeding, even if scant. In most cases, mild anovulatory DUB stops with the OCP and regular withdrawal bleeding during the placebo week of the pill cycle

is established. After 3–6 months of regular menses on the pill, a trial without it can be considered. The stable adolescent with mild-moderate anemia (i.e., hemoglobin level > 9.0 g/dl) should be managed with combined estrogen-progestin therapy for at least 3–6 months, as outlined in Box 22-3. Emergent care is essential for the unstable patient, and prompt inpatient care is recommended for the patient with a hemoglobin level < 9.0 g/dl who continues to have heavy bleeding. Of note, the initial hemoglobin and hematocrit values may be falsely elevated in an unstable patient and may decrease significantly with fluid resuscitation. Patients requiring the combined OCP several times daily for acute control of bleeding often benefit from the simultaneous administration of an anti-emetic to control the nausea associated with high-dose estrogen. Once the oral contraceptive is reduced to the maintenance dose of one pill daily, oral iron replacement therapy (i.e., 60 mg elemental iron orally three times daily) should be started for all patients with anemia and continued for at least 8 weeks. Hormonal therapy for an adolescent with DUB usually consists of estrogen and progestin, administered as a monophasic combined OCP. Estrogen facilitates hemostasis and endometrial healing. Progestin halts endometrial proliferation and stabilizes the endometrial lining. Once the bleeding has stopped, the oral contraceptive should be continued as one pill daily until there is significant improvement in the hemoglobin level or for a minimum of 3 weeks to allow endometrial repair. At that point, the pill is stopped for 1 week and a withdrawal bleed occurs. The patient should be warned that this withdrawal bleed is likely to be heavy but painless and limited in duration, secondary to the endometrial proliferation induced by the high-dose estrogen during the initial phase of treatment. The oral contraceptive should then be cycled for 3–6 months according to the usual pill pack instructions to allow the endometrium to heal completely. Extended hormone replacement for up to 3 months prior to a withdrawal week is an option but is more likely to be associated with unpredictable breakthrough bleeding due to the prolonged endometrial stimulation and proliferation. Norethindrone acetate or medroxyprogesterone acetate are progestin-only alternatives that can be used for the control of bleeding in patients who cannot tolerate estrogen or for whom it is contraindicated. Acutely, the progestin may be required in higher dosage and should be administered orally or intramuscularly. Once the bleeding stops, the progestin should be continued as a daily pill, a long-acting intramuscular injection (i.e., depot medroxyprogesterone acetate), or a progestin-containing intrauterine device (IUD). Intravenous estrogen is available for patients who cannot tolerate or continue to bleed on the OCP. Of note, progestin should be administered with the estrogen to stabilize the endometrial lining. Conjugated estrogen in a

160 Adolescent Medicine: The Requisites in Pediatrics

dose of 25 mg intravenously every 4–6 hours is administered for a maximum of four doses. When the bleeding is controlled, the estrogen and progestin should be continued as the OCP as noted previously and in Box 22-3. Rarely, transfusion of packed red blood cells is required for patients with severe anemia that has developed quickly. Most adolescents in whom the anemia has developed gradually, even if severe, are hemodynamically stable and do not require transfusion. Other treatment modalities can be utilized as adjuncts to hormonal therapy for the acute management of severe or prolonged DUB, such as methergine or misoprostol, which stimulate uterine contraction. Antifibrinolytic therapy aids in preventing dissolution of clot and is commercially available in the United States as Amicar (aminocaproic acid). In patients with von Willebrand disease, an infusion of vWFrich Factor VIII (i.e., Humate P) may be necessary acutely. These patients may also benefit from long-term use of the combined OCP therapy because the estrogen component of the pill increases vWF and Factor VIII levels. Adolescents with von Willebrand disease or other causes of platelet dysfunction and those with the hemophilia gene who experience recurrent menorrhagia despite hormonal therapy may benefit from desmopressin (DDAVP) administered as a highly concentrated nasal spray (Stimate). DDAVP is a synthetic analog of antidiuretic hormone that increases vWF and Factor VIII levels, as well as platelet adhesion to vessel walls. The usual dose of Stimate is one puff in each nostril for the first 1–3 days of menses, and weights should be monitored daily because of the antidiuretic effect. Oral antifibrinolytic therapy may be considered for those patients who do not respond to Stimate. However, frequent, high dosing is typically required for oral antifibinolytic medications, with associated gastrointestinal side effects and low patient adherence to the regimen.

Primary Dysmenorrhea Definitions Dysmenorrhea: Painful menstruation. Primary dysmenorrhea: Painful menstruation with no apparent pelvic pathology. This chapter focuses on primary dysmenorrhea. Secondary dysmenorrhea: Painful menstruation caused by pelvic pathology, such as endometriosis, outflow tract obstruction, or PID. Chapter 23 discusses secondary dysmenorrhea.

Epidemiology Dysmenorrhea is the most common cause of missed school and work time by females, estimated at more than

140 million lost hours per year. Dysmenorrhea of varying severity accompanies 20–90% of adolescent menstrual cycles. The prevalence of primary dysmenorrhea increases with adolescent gynecological age (i.e., time since menarche) due to its association with ovulatory cycles (see following discussion), peaks at age 17 years, and decreases with parity. Severe dysmenorrhea that significantly interferes with function 1–3 days per month affects 5–42% of adolescents and is more likely be primary than secondary in origin.

Pathophysiology Primary dysmenorrhea is caused by hypercontraction of the myometrium, tissue ischemia, and hypersensitivity of pain nerve terminals in the uterine cavity. The underlying mechanism involves the endometrial production and secretion of prostaglandin F2 alpha (PGF2α) and prostaglandin E2 (PGE2) during menses. PGF2α is primarily responsible for the symptoms of dysmenorrhea, producing the uterine contractions and ischemia as well as mediating pain sensation. Endometrial levels of PGF2α and PGE2 are higher in the secretory than proliferative phase of the menstrual cycle, supporting the association of primary dysmenorrhea with ovulatory cycles; are highest in the first two days of flow, explaining why dysmenorrhea is more severe in the beginning than end of menses; and are higher in women with than without dysmenorrhea. Although serum levels of PGF2α and PGE 2 are not increased during menstruation, studies have demonstrated that intravenous infusion of PGF2α induces systemic symptoms similar to those that are associated with primary dysmenorrhea (e.g., headache, nausea, vomiting, backache, diarrhea, dizziness, and fatigue). The causative role of prostaglandins is further supported by consistent evidence demonstrating the effectiveness of prostaglandin synthetase inhibitors (i.e., NSAIDs) in the treatment of primary dysmenorrhea.

Evaluation Key questions to ask the adolescent with dysmenorrhea include the following: Did the pain begin with menarche? Was the pain as severe when it began as it is now? Does the pain occur only during menstruation? Menstrual duration, flow, and interval should be reviewed, along with changes in cycle pattern over time. The effect of dysmenorrhea on the adolescent’s function should be discussed in detail, including missed school and decreased social involvement. Those adolescents who have tried NSAIDs without success should be asked when they begin the medication. NSAIDs are most effective when begun with or shortly before the onset of pain because their primary mechanism of action is to decrease endometrial production of prostaglandins.

Menstrual Disorders 161



The history should also include questions about sexual activity, STIs, and sexual risk behaviors (e.g., number of lifetime partners, new partner within the past 3 months, non-use of condoms). A thorough review of systems is important because of the many non-gynecological conditions that can cause pelvic pain (Box 22-4). The psychosocial history should include questions about stress, substance abuse, and cigarette smoking, which has been specifically associated with dysmenorrhea. Pelvic examination generally can be deferred in the adolescent with probable primary dysmenorrhea who denies history of sexual intercourse. The insertion of a moistened cotton swab into the vaginal canal can help rule out a hymenal abnormality or vaginal septum, and recto-abdominal examination can help identify a mass when bimanual vaginal examination is difficult. Labora­ tory testing is unnecessary in the adolescent with probable primary dysmenorrhea. If the history or physical examination suggests that the dysmenorrhea is secondary to organic pathology, the specific condition that is suspected should guide testing (Chapter 23).

Management First- and second-line therapies for primary dysmenorrhea are NSAIDs and OCPs, respectively. Clinicians should explain that primary dysmenorrhea is normal but uncomfortable and that the symptoms can be controlled. Many studies have demonstrated that adolescents typically know little about effective treatment options for dysmenorrhea, and even those who use NSAIDs typically do not begin them before the onset of pain.

Box 22-4  Non-Gynecological Causes of

Pelvic Pain

l l l l l l l l l l l l l l

Gastrointestinal disorders Inflammatory bowel disease Irritable bowel syndrome Constipation Lactose intolerance Musculoskeletal pain Inflammatory process Trauma Tumor Cystitis Ureteral obstruction Calculi Psychogenic disorders History of abuse

NSAIDs are divided into several groups, including salicylic acids, acetic acids, propionic acids, fenamates, benzenesulfonamides, furanones, and oxicams. Those that are best-studied and most widely used for the treatment of dysmenorrhea are the propionic acids (e.g., ibuprofen, naproxen) and fenamates (e.g., mefenamic acid). Mefenamic acid may be advantageous in some clinical situations because it competes with prostaglandins for binding sites, thus antagonizing prostaglandin action as well as inhibiting prostaglandin synthesis. The typical dosing patterns of commonly used NSAIDS are shown in Table 22-1. NSAIDs should be started either with the onset of pain if it precedes menses or with the first sign of menstruation. There is no proven advantage to starting prior to the onset of menses in an individual whose pain begins after the onset of bleeding. NSAIDs typically are needed for only 1–3 days and are associated with minimal side effects when used in the recommended doses. Each formulation should be tried for two or three menstrual cycles, and a 6-month trial with at least two different formulations is recommended before deciding that NSAIDs are ineffective. Hormonal therapy can be added to NSAIDs for patients with ongoing discomfort or can be used alone for patients who do not tolerate NSAIDs or derive no benefit from them. OCPs have been shown to decrease symptoms in more than 90% of patients with primary dysmenorrhea. The mechanisms of action include the inhibition of ovulation and the development of an atrophic endometrium, with resultant decreases in prostaglandins and menstrual flow. The patient should be counseled that maximal effect may be delayed for several cycles. If dysmenorrhea persists on the 28-day cycle of the usual OCP pack, the patient can skip the placebo pills and take only the hormone-containing pills for up to 3 months before allowing 7 days without hormones for a withdrawal bleed. Progestin-only methods, such as injectable depot medroxyprogesterone acetate (Depo-Provera) and the levonorgestrel-releasing intrauterine system (Mirena), also are effective for the treatment of dysmenorrhea.

Table 22-1  NSAID Regimens for Dysmenorrhea NSAID Ibuprofen

First Dose (mg) 400–600

Naproxen Naproxen sodium

500 550

Mefenamic acid

500

Subsequent Dose (mg) 400 every 4–6 hours or 600 every 6 hours 250 every 6–8 hours 275 every 6–8 hours or 550 every 12 hours 250 every 6 hours

162 Adolescent Medicine: The Requisites in Pediatrics

Some studies suggest that oral supplementation with vitamin B1, magnesium, and vitamin E may be helpful in the management of dysmenorrhea. GnRH agonists may be needed for the control of dysmenorrhea secondary to endometriosis but rarely are indicated for primary dysmenorrhea.

Premenstrual Syndrome Definitions Premenstrual dysphoric disorder (PMDD) is defined by the Diagnostic and Statistical Manual of Mental Health Disorders, 4th edition (DSM-IV-TR) according to the criteria noted in Box 22-5. The symptoms of PMDD are more severe than those of PMS and predominantly affect mood. Premenstrual syndrome (PMS) a constellation of predictable physical, cognitive, affective, and behavioral symptoms that occur cyclically, beginning with ovulation, continuing during the luteal phase of the menstrual cycle, and quickly resolving with menstruation. To date, there is no universally accepted definition or set of diagnostic criteria for PMS.

Epidemiology An estimated 70–90% of women experience some premenstrual symptoms. The 3–8% of these women who describe the symptoms as severe enough to affect quality of life probably represents the subgroup with PMDD. More than 200 symptoms have been described in the literature, the most common of which are listed in Box 22-6. At least one premenstrual symptom is reported by 50– 100% of adolescents, and 14–89% of adolescents describe their symptoms as moderate to severe. There is a higher concordance of PMS among monozygotic than dizygotic twins, and a maternal history of PMS increases the likelihood of its development. The prevalence of PMS increases with advancing age beyond 30 years.

Pathophysiology PMS probably represents an interaction between sex steroids and central neurotransmitters. There is some evidence supporting reduced serotonergic function in the luteal phase of the menstrual cycle and alteration in the response of the gamma aminobutyric acid (GABA) receptor complex. Although serotonergic dysregulation is the most plausible theory, variable response to selective serotonin reuptake inhibitors (SSRIs) implies the involvement of other factors. Estrogen, progesterone, and testosterone levels are normal, but women with PMS/PMDD may be more vulnerable to the normal cyclical fluctuations in

Box 22-5  DSM-IV-TR Criteria for the

Diagnosis of PMDD

I. In most menstrual cycles in the past year at least five of these symptoms (including at least one of the symptoms in category A) were present for most of the time 1 week before menses, began to remit within a few days after the onset of the follicular phase (menses), and were absent in the week after menses.

A. Principal Symptoms 1.  Markedly depressed mood, feelings of hopelessness or self-deprecating thoughts 2. Marked anxiety, tension 3. Marked affective lability (i.e., feeling suddenly sad or tearful) 4. Persistent and marked anger or irritability or increased interpersonal conflicts B. Other Symptoms 1. Decreased interest in usual activities such as friends and hobbies 2. Subjective sense of difficulty in concentrating 3. Lethargy, easy fatigability, or marked lack of energy 4. Marked change in appetite, overeating, or specific food cravings 5. Hypersomnia or insomnia 6. A subjective sense of being overwhelmed or out of control 7. Other physical symptoms (e.g., breast tenderness, bloating, weight gain, headache, joint or muscle pain)

II. The symptoms markedly interfere with work, school, usual activities, or relationships with others. III. Symptoms are not merely an exacerbation of another disorder, such as major depressive disorder, panic disorder, dysthymic disorder, or a personality disorder (although it may be superimposed on any of these disorders). Criteria I, II, and III are confirmed by prospective daily ratings for at least two consecutive symptomatic menstrual cycles. Adapted from: American Psychiatric Association. Diagnosis and Statistical Manual of Mental Disorders, 4th edition. DSM-IV-Text Revision. DSM-IV-TR. Washington, D.C. American Psychiatric Association, 2000.

serum levels of these hormones. Current evidence does not support associations of PMS with prolactin, growth hormone, thyroid hormone, adrenal hormones, luteinizing hormone (LH), follicle-stimulating hormone (FSH), antidiuretic hormone, insulin, zinc, vitamin A, vitamin E, thiamine, magnesium, or pyridoxine.

Evaluation There are no universally accepted findings on physical examination or laboratory evaluation that establish a diagnosis of PMS or PMDD. Important findings on history are as

Menstrual Disorders 163



Box 22-6  Symptoms Associated with PMS

Box 22-7  Approach to the Treatment of

Emotional Symptoms

Step 1a: Mild-moderate symptoms:

and PMDD

l l l l l l l l l l l

Irritability Depression Fatigue or lethargy Anger/argumentative Insomnia or hypersomnia Mood lability Anxiety Poor concentration Confusion Tearfulness Social withdrawal

Physical Symptoms l l l l l l l l

Headaches Swelling: legs or breasts; breast tenderness Increased appetite Food cravings Weight gain Sense of abdominal bloating Fatigue Muscle and joint aches and pain

follows: (1) symptoms occur in the luteal phase and resolve within a few days of menses; (2) symptoms recur over at least three menstrual cycles and cannot be explained by other physical or psychological problems; and (3) symptoms are severe enough to disrupt normal activities. PMS and PMDD can be exacerbated by and/or exacerbate (i.e., menstrual magnification) co-existing psychiatric or medical conditions such as seizures, migraine headaches, irritable bowel syndrome, asthma, and allergies.

Management A stepwise approach to the management of PMS and PMDD is outlined in Box 22-7. For adults with severe symptoms, SSRIs are considered first-line therapy. Placebo-controlled studies have demonstrated improvements in both physical symptoms and mood with fluoxetine, sertraline, paroxetine, citalopram, escitalopram, and venlafaxine. Unlike depression, the symptoms of PMS and PMDD typically improve within 24–28 hours of initiating therapy. Furthermore, the medications appear to be equally effective when used either continuously or only during the luteal phase (i.e., the 14 days following ovulation). Low-dose therapy is usually sufficient, and intermittent use has not been associated with symptoms of SSRI withdrawal. It is important to note that fluoxetine is the only SSRI approved for use in adolescents < 18 years of age. Studies suggest more vari-

PMS and PMDD

l

Complex carbohydrates, aerobic exercise, calcium supplementation, and possibly magnesium or chasteberry fruit.

Step1b: Physical symptoms predominate: l

Spironolactone, oral contraceptive, Depo-Provera, NSAIDs.

Step 2: Mood symptoms predominate: l

SSRI or an anxiolytic medication.

Step 3: No response to Steps 1 or 2: l

Gynecological consultation about GnRH agonists.

Adapted from: American College of Obstetricans and Gynecologists: Premenstrual syndrome. ACOG Practice Bulletin #15. Washington, D.C., American College of Obstetricians and Gynecologists, April, 2000; and Johnson SR: Premenstrual syndrome, premenstrual dysphoric disorder, and beyond: A clinical primer for practitioners. Obstet Gynecol 2004;104:845–859.

able effectiveness with the continuous or intermittent use of alprazolam, which affects the GABA receptor complex; clomipramine, which is a nonselective serotonin receptor agonist; and buspirone, which is a partial serotonin receptor agonist. Studies exploring the use of OCPs for PMS or PMDD have yielded inconsistent results. A double-blind, placebo-controlled study of an oral contraceptive containing drospirenone and ethinyl estradiol 30  mcg in women with PMDD demonstrated improvement in a few physical symptoms. Another study of a newer formulation containing drospirenone and ethinyl estradiol (20  mcg) daily for 24 days and nonactive pills for 4 days (24/4 regimen) rather than the usual 21/7, showed improvement in both mood and physical symptoms. Generally, OCPs can be considered if the symptoms are primarily physical. Other regimens to suppress ovulation can also be considered, such as continuous use of oral contraceptives for 3 months and the injectable depot medroxyprogesterone acetate (Depo-Provera). GnRH has been shown to be effective in adult women for the treatment of PMS and PMDD but is associated with severe hypoestrogenemia and increased risk of osteoporosis. GnRH with add-back estrogen-progestin therapy can be considered in adults when other modalities have failed but is rarely indicated for adolescents with PMS or PMDD. Spironolactone may help reduce premenstrual breast tenderness, bloating, or weight gain from fluid retention in some patients. Similarly, NSAIDs may help control some physical symptoms. Evidence

164 Adolescent Medicine: The Requisites in Pediatrics

remains limited regarding the use of mineral supplementation, herbal preparations, and dietary manipulation. One of the most promising interventions is calcium (1200 mg/day) in the form of calcium carbonate, which has been reported to reduce physical and emotional symptoms in a well-designed, multicenter study. A prospective case-control study, nested in the Nurses’ Health Study II, demonstrated that the risk of developing PMS was reduced among women with high intake of calcium and vitamin D. Magnesium supplementation (200 to 400  mg/day) has been noted in some studies to reduce negative mood and water retention, but the mechanism of action is not understood and data are limited. Placebo-controlled trials have demonstrated the possible effectiveness of chasteberry; ginko leaf extract for breast tenderness, fluid retention, and mood; and carbohydrates for the control of food craving and mood. The mechanism of action for the latter may involve an increase in tryptophan, which is a precursor to serotonin. Evidence is limited regarding the effectiveness of pyridoxine (vitamin B6) and vitamin E.

Bibliography American College of Obstetricians and Gynecologists: Premen­ strual syndrome.  ACOG Practice Bulletin #15. Washington D.C., American College of Obstetricians and Gynecologists, 2000. American College of Obstetricians and Gynecologists: ACOG Committee Opinion. Number 310, April 2005. Endometriosis in adolescents. Obstet Gynecol 2005;105:921–927. Bertone-Johnson ER, Hankinson SE, Bendich A, et al.: Calcium and vitamin D intake and the risk of incident premenstrual syndrome. Arch Int Med 2005;165:1246–1252. Bevan JA, Maloney KW, Hillery CA, et al.: Bleeding disorders: A common cause of menorrhagia in adolescents. J Pediatr 2001;138:856–861. Chumlea WC, Schubert CM, Roche AF, et al.: Age at menarche and racial comparisons in US girls. Pediatrics 2003;111:110– 113. Davis AR, Westhoff C, O’Connell K, et al.: Oral contraceptives for dysmenorrhea in adolescent girls:A randomized trial. Obstet Gynecol Jul 2005;106:97–104. Dimmock PW, Wyatt KM, Jones PW, et al.: Efficacy of selective serotonin-reuptake inhibitors in premenstrual syndrome: A systematic review. Lancet 2000;356:1131–1136. Emans SJ, Laufer MR, Goldstein DP. Pediatric and Adolescent Gynecology, 5th ed. Philadelphia, Lippincott Williams & Wilkins, 2005.



Major Points

b

All patients with amenorrhea should be evaluated to determine pubertal staging and the presence of normal genital anatomy. l During adolescence, eating disorders and excessive exercise are common causes of secondary amenorrhea. l PCOS should be considered in the differential diagnoses of both amenorrhea and abnormal uterine bleeding. l Anovulation is the most common cause of abnormal uterine bleeding in adolescents. l Inherited bleeding disorders should always be considered in adolescents with heavy or prolonged uterine bleeding that began with menarche. l Endometrial prostaglandins are responsible for the uterine contractions, tissue ischemia, and stimulation of endometrial pain nerve terminals of primary dysmenorrhea. l Adolescents with dysmenorrhea who do not respond to medical therapy should be evaluated for endometriosis or outflow tract anomalies. l Most menstruating adolescents have at least one premenstrual symptom. l The diagnoses PMS and PMDD depend on recurrence over at least three cycles with adverse effects on school, work, and social function. l

Grady-Weliky TA: Clinical practice. Premenstrual dysphoric disorder. N Engl J Med 2003;348:433–438. Halbreich U: The diagnosis of premenstrual syndromes and premenstrual dysphoric disorder—Clinical procedures and research perspectives. Gynecol Endocrinol 2004;19:320–334. Joffe H, Cohen LS, Harlow BL: Impact of oral contraceptive pill use on premenstrual mood: Predictors of improvement and deterioration. Am J Obstet Gynecol 2003;189:1523–1530. Johnson SR: Premenstrual syndrome, premenstrual dysphoric disorder, and beyond: A clinical primer for practitioners. Obstet Gynecol 2004;104:845–859. Laufer MR: Congenital absence of the vagina: In search of the perfect solution. When, and by what technique, should a vagina be created? Curr Opin Obstet Gynecol 2002;14:441–444. Laufer MR, Goitein L, Bush M, et al.: Prevalence of endometriosis in adolescent girls with chronic pelvic pain not responding to conventional therapy. J Pediatr Adolesc Gynecol 1997;10:199–202. Marjoribanks J, Proctor ML, Farquhar C: Nonsteroidal antiinflammatory drugs for primary dysmenorrhoea. Cochrane Database Syst Rev 2003;(4):CD001751. Rapkin AJ: New treatment approaches for premenstrual disorders. Am J Manag Care 2005;11:S480–S491. Wyatt KM, Dimmock PW, O’Brien PM: Selective serotonin reuptake inhibitors for premenstrual syndrome. The Cochrane Database Syst Rev 2002;(4):CD001396. Yonkers KA, Brown C, Pearlstein TB, et al.: Efficacy of a new low-dose oral contraceptive with drospirenone in premenstrual dysphoric disorder. Obstet Gynecol 2005;106:492–501.

C h A p t e r

23

Introduction Definitions Pathophysiology Gonadotropin Abnormalities Ovarian and Adrenal Steroid Abnormalities Metabolic Abnormalities Genetics Environmental Factors Developmental Hypotheses Clinical Manifestations Clinical Sequelae Laboratory and Radiographic Findings

Diagnosis Evaluation Management Combined Estrogen/Progestin or Progestin-Only Therapy Antiandrogens Insulin-Sensitizing Agents Lifestyle Changes, Education, and Counseling

Introduction Polycystic ovary syndrome (PCOS) may be the most common endocrine disorder in women of reproductive age, occurring in 4–6% of adolescents and 4–12% of adult women. In 1935, Stein and Leventhal first reported the association of polycystic ovaries with amenorrhea, hirsutism, and obesity. PCOS is now recognized as a syndrome characterized by ovarian dysfunction, increased androgen production, and disordered gonadotropin secretion. These abnormalities may cause anovulatory infertility, menstrual dysfunction, hirsutism, and acne. PCOS also is associated with metabolic abnormalities, including insulin resistance and hyperinsulinemia. Women with PCOS are at increased risk for  Type 2 diabetes mellitus, dyslipidemia, and cardiovascular disease.

Polycystic Ovary Syndrome Jessica A. Kahn, MD, MPH

Recent research has shown that childhood conditions such as low birth weight and premature adrenarche are risk factors for PCOS.  The manifestations of PCOS begin to appear with the onset of puberty and may adversely affect body image and self-esteem. Early diagnosis and treatment can help control the physical manifestations during adolescence and decrease clinical sequelae in adulthood.

Definitions Acanthosis nigricans:  Velvety, hyperpigmented, verrucous skin associated with insulin resistance. Gonadotropins: Luteinizing hormone (LH) and follicle stimulating hormone (FSH), secreted by the anterior pituitary. Hirsutism:  An increased quantity and distribution of coarse, pigmented hair in females. Idiopathic hirsutism: Hirsutism without hyperandrogenemia, menstrual irregularity, or an identifiable cause. Late-onset congenital adrenal hyperplasia (CAH): 21-hydroxylase deficiency, resulting in elevated level of serum 17α-hydroxyprogesterone. Metabolic syndrome: Definition in children and adolescents: waist circumference > 90th percentile; blood pressure > 90th percentile; fasting plasma glucose > 110  mg/dl; serum triglycerides > 110/ml; serum HDL cholesterol > 40 mg/dl. Polycystic ovaries: 12 or more follicles in each ovary, each > 2–9 mm, or ovarian volume > 10 ml. Premature adrenarche:  The development of pubic hair in girls younger than 8 years and boys younger than 9 years due to adrenal hyperandrogenism. Pubarche: Onset of pubic hair growth. Thelarche: Onset of breast development. 165

166 Adolescent Medicine: The Requisites in Pediatrics

Virilization: A manifestation of hyperandrogenemia; signs include acne, clitoromegaly, voice deepening, increased muscle mass, and frontal balding.

Pathophysiology The pathogenesis of PCOS is not well defined. However, research has shown that gonadotropin, ovarian steroid, adrenal steroid, metabolic, and genetic abnormalities all appear to be involved.

Gonadotropin Abnormalities PCOS is characterized by a relative increase in the secretion of luteinizing hormone (LH) and a relative decrease in the secretion of follicle-stimulating hormone (FSH). Approximately 55–75% of women with PCOS have an elevated LH:FSH ratio (> 2.5:1), and administration of gonadotropin-releasing hormone (GnRH) evokes an exaggerated LH response. Women with PCOS may have increased LH pulse frequency, increased LH amplitude, and abnormal diurnal rhythm of LH secretion. The mechanism underlying LH hypersecretion may reflect impaired hypothalamic sensitivity to feedback inhibition from ovarian steroids such as estradiol, progesterone, and androgens. FSH secretion is similar to that of women in the early follicular phase of the menstrual cycle. High LH levels (which stimulate theca-interstitial cell secretion of androgens) and relatively low FSH levels (which prevent efficient aromatization) may lead to excess androgen production by the ovary.

Ovarian and Adrenal Steroid Abnormalities Intrinsic defects in ovarian steroidogenesis, particularly dysregulation of ovarian androgen secretion, play a central role in the pathogenesis of PCOS.  Thecal cells isolated from polycystic ovary follicles secrete increased amounts of androstenedione, 17α-hydroxyprogesterone, and progesterone, both basally and in response to LH. Ovarian androgen biosynthesis occurs primarily in the thecal-interstitial cells, and the excessive androgen production in women with PCOS appears to be caused by increased activity in the thecal cell steroid production pathway. Recent studies suggest that hyperandrogenemia in women with PCOS is the result of several defects in thecal cell steroidogenesis, rather than a molecular or genetic defect affecting a single steroidogenic enzyme. For example, the function of the thecal enzyme cytochrome P450c17 (CYP17) is dysregulated in women with PCOS. This enzyme has 17α-hydroxylase and 17,20-lyase activity. The latter enzyme is the rate-limiting step in androgen formation. Thecal cells from women with PCOS demonstrate elevated gene expression and activity of 17α-hydroxylase. Granulosa cells also exhibit some dysregulation of steroidogenesis and

may contribute to hyperandrogenism. Hyperinsulinemia, which is commonly found in women with PCOS, may exacerbate steroidogenic dysregulation. Intrinsic defects in ovarian steroidogenesis are thought to contribute to impaired folliculogenesis, which is a key feature of PCOS. The earliest abnormalities in women with PCOS are an increased number of early-growing follicles, arrested development of these follicles at a diameter of 4–8 mm, and impairment in the selection of a dominant follicle. Excessive intraovarian androgens appear to interfere with selection of a dominant ovarian follicle and thus with ovulation. In addition, granulosa cells produce inhibins, which regulate follicular steroidogenesis. Inhibin A and B concentrations are reduced in the follicular fluid of women with PCOS, suggesting that inhibin deficiency may play a role in the abnormal follicular maturation noted in women with PCOS. Although the ovary is the principal source of excess androgen secretion, 50–60% of women with PCOS also have elevated levels of adrenal androgens. Increased 17, 20-hydroxlyase activity and adrenal androgen hyper­responsiveness to ACTH are thought to be two major abnormalities leading to adrenal androgen excess in PCOS, and both may be promoted by elevated ovarian androgens.

Metabolic Abnormalities Many women with PCOS have hyperinsulinemia on the basis of insulin resistance and compensatory insulin secretion by the β-cells of the pancreas. Obesity is common in women with PCOS, and these women tend to have lower insulin sensitivity and higher insulin levels than obese women in the general population. A number of studies, although not all, have demonstrated that nonobese women with PCOS are more likely to have hyperinsulinemia than nonobese women without PCOS. Several defects in the pathways that mediate insulin action and signaling are likely to be responsible for insulin resistance in women with PCOS. One of these appears to be a postbinding defect in insulin-mediated signal transduction, mediated in some women by abnormal serine phosphorylation of the insulin receptor.  Approximately 50% of women with PCOS had increased serine phosphorylation of the insulin receptor, which decreases protein tyrosine kinase activity. Studies have shown that a factor extrinsic to the receptor, possibly serine kinase, is responsible for serine phosphorylation.  Because serine phosphorylation modulates the activity of P450c17 (an enzyme that regulates the synthesis of sex steroids), a genetic defect involving serine protein kinase may cause both insulin resistance and excessive androgen production. Insulin may increase ovarian androgen production directly through the stimulation of steroidogenesis in granulosa or thecal cells, as well as indirectly through the stimulation of LH secretion or the inhibition of hepatic production of insulin-like growth factor 1 binding protein (IGFBP-1).

Polycystic Ovary Syndrome 167



Finally, insulin may increase bioavailable androgens by inhibiting liver synthesis and secretion of sex hormonebinding globulin (SHBG). Studies have also demonstrated that insulin may increase adrenal androgen production.

of free fatty acids that affect insulin clearance, cell uptake of glucose, and glycogen synthesis; and adipocyte secretion of tumor necrosis factor α (TNFα), which may play a role in the pathogenesis of insulin resistance in women with PCOS.

Genetics Familial clustering of PCOS has been well documented, suggesting that genetic abnormalities are likely to play a role in its pathogenesis. The concordance rate for PCOS is 74% among monozygotic twins, 60% among dizygotic twins, and 22% among sisters. Candidate PCOS genes include those involved in ovarian steroidogenesis (CYP11a, CYP17, and CYP21), steroid hormone function (androgen receptor gene, sex hormone binding globulin gene), gonadotropin function (LH gene, LH receptor gene, follistatin gene), insulin secretion and action (variable number tandem repeats or VNTR, insulin receptor gene, insulin receptor substrate protein genes, calpain 10 gene), adipose tissue metabolism (leptin gene, leptin receptor gene, peroxime proliferators-activated receptor-gamma gene), and chronic inflammation (plasminogen activator inhibitor-1). Although many gene mutations and polymorphisms have been identified in women with PCOS, studies have not identified a specific gene or genes that appear to play a principal role in PCOS pathogenesis or to have obvious clinical significance. The clinical and biochemical variability of PCOS may be explained by genetic heterogeneity and/or the interaction of environmental factors, such as those related to obesity and diet, with a small number of genes, such as those involved in androgen production and insulin secretion or action.

Environmental Factors Central obesity and diets high in saturated fats appear to be independent environmental risk factors for PCOS. Postulated mechanisms include the increased ­production

Developmental Hypotheses Nobels and Dewailley noted in the early 1990s that there is a striking resemblance between the endocrine characteristics of puberty and PCOS.  They pointed out that both conditions are characterized by insulin resistance, hyperpulsatile gonadotropin secretion, hyperactive ovarian and adrenal androgen synthesis, and decreased levels of IGFBP-1 and SHBG. They proposed that PCOS may be thought of as an exaggerated transition to puberty and that increasing insulin levels and IGF-1 activity during puberty may predispose susceptible adolescents to developing PCOS. Abbott et al. have hypothesized, based on animal models and human studies, that the clinical and biochemical features of PCOS are a consequence of genetically determined hypersecretion of androgens by the ovary during or before puberty.  They suggest that hyperandrogenism then results in “programming” of the hypothalamic–­pituitary axis to secrete excess LH and promotes abdominal adiposity that predisposes to insulin resistance. Finally, they propose that the severity of hyperinsulinemia and insulin resistance is influenced by genetic factors, such as polymorphism in the insulin gene regulatory region, as well as environmental factors such as obesity. A diagram summarizing the hypothesized relationships between hyperinsulinemia and hyperandrogenemia and their role in the pathogenesis of PCOS is shown in Figure 23-1.   The figure illustrates the importance of both genetic and environmental factors in the pathogenesis of PCOS.

Central obesity

Insulin resistance

Adipose tissue

Hyperinsulinemia

Genetic factors

TNFα, FFA

Figure 23-1 Hypothesized pathogenesis of PCOS. Created by author.

Adrenal

↑IGF-1

Liver

↓SHBG

↓IGFBP-1

↑Androgen activity

↑IGF-1

↑Luteinizing hormone

Ovary Thecal hyperplasia (→ impaired folliculogenesis, anovulation)

168 Adolescent Medicine: The Requisites in Pediatrics

Clinical Manifestations The clinical manifestations of PCOS typically begin to appear with the onset of puberty. However, girls younger than 8 years with pubic hair and elevated adrenal androgens (i.e., premature adrenarche) appear to be at subsequent risk for excess androgen production by both the adrenals and ovaries and insulin resistance. Premature adrenarche therefore may represent the earliest PCOS phenotype. Adolescents with PCOS typically present with symptoms and physical findings related to hyperandrogenism, anovulation, and insulin resistance. Clinical sequelae that are more commonly seen during adulthood include   Type 2 diabetes mellitus, the metabolic syndrome, and cardiovascular disease. Hyperandrogenism in patients with PCOS commonly presents with hirsutism and acne. Hirsutism is defined as the presence of excess terminal hair in females. Terminal hair (in contrast to vellus or lanugo hair) is coarse, pigmented, and > 0.5 cm long. Deciding whether the quantity or pattern of terminal hair is excessive can be highly subjective and is aided by the use of the Ferriman-Gallwey system, depicted in Table 23-1 and Figure 23-2. Acne, as discussed in Chapter 15, is caused by excess sebum production and the proliferation of keratinocytes, both of which are stimulated by androgens. Signs of virilization, such as clitoromegaly, frontal balding, deepening of the voice, and increased muscle mass, are uncommon in PCOS and should prompt evaluation for other causes of hyperandrogenism (see Evaluation, later). Anovulation can present as oligomenorrhea, amenorrhea, dysfunctional uterine bleeding, or infertility (Chapter 22). Although anovulatory cycles during the 2 years following menarche are commonly attributed to physiological immaturity of the hypothalamic–pituitary– ovarian axis, a study comparing postmenarcheal adolescents with regular vs. irregular menses revealed higher androgen and LH level in the latter, consistent with early PCOS. In adult women with secondary amenorrhea or oligomenorrhea, PCOS accounts for 30–40% and 85–90% of cases, respectively, and is a frequent cause of infertility. Insulin resistance and compensatory hyperinsulinemia begin early in the course of PCOS, particularly in obese adolescents. Acanthosis nigricans is associated with insulin resistance but is neither a sensitive nor specific marker for it. Morphologically, skin fold areas (e.g., posterior neck, axillae, inframammary folds, and vulvae) appear velvety, hyperpigmented, and verrucous (Figure 23-3). Histologically, there is hyperkeratosis and epidermal papillomatosis. Central obesity, or a waist circumference in females > 88 cm, is highly correlated with insulin resistance. Studies have demonstrated a wide range in the

Table 23-1 The Ferriman-Gallwey System for Scoring Hirsutism Site

Grade1

Definition

Upper lip

1 2 3

A few hairs at outer margin. A small moustache at outer margin. A moustache extending halfway from outer margin. A moustache extending to mid-line. A few scattered hairs. Scattered hairs with small concentrations. Complete cover, light and heavy. Circumareolar hairs. With mid-line hair in addition. Fusion of these areas, with threequarter cover. Complete cover. A few scattered hairs. Rather more, still scattered. Complete cover, light and heavy. A sacral tuft of hair. With some lateral extension. Three-quarter cover. Complete cover. A few mid-line hairs. Rather more, still mid-line. Half and full cover. A few mid-line hairs. A mid-line streak of hair. A mid-line band of hair. An inverted V-shaped growth. Sparse growth affecting not more than a quarter of the limb surface. More than this; cover still incomplete. Complete cover, light and heavy. Complete cover of dorsal surface; 2 grades of light and 2 of heavy growth. As for arm. As for arm.

Chin

Chest

Upper back

Lower back

Upper abdomen

Lower abdomen

Arm

4 1 2 3, 4 1 2 3 4 1 2 3, 4 1 2 3 4 1 2 3, 4 1 2 3 4 1 2

Forearm

3, 4 1, 2, 3, 4

Thigh Leg

1, 2, 3, 4 1, 2, 3, 4

1 Grade 0 at all sites indicates absence of terminal hair; a total score of 8 or more indicates hirsutism. From: Hatch R, Rosenfield RL, Kim MH, et al.: Hirsutism: Implications, etiology, and management. Am J Obstet Gynecol 1981;140:815–830. Adapted from Ferriman D, Gallwey JD: Clinical

prevalence of obesity among patients with PCOS, but recent data indicate that at least 50% of adult women with PCOS are obese. Furthermore, even nonobese women with PCOS appear to have higher total body fat than nonobese women without PCOS. Glucose intolerance or Type 2 diabetes mellitus affects approximately 20–40% of obese young women with PCOS and is often associated with the metabolic syndrome (see Definitions, previously). Adolescents with PCOS are up to 4.5 times more likely to have metabolic syndrome than age-matched controls after adjusting for body mass index.

Polycystic Ovary Syndrome 169



1

2

3

4

1

2

3

4

1

2

3

4

Figure 23-3 Axillary acanthosis nigricans. 1

2

3

4

Photograph courtesy of Jill Huppert, M.D., M.P.H.

Clinical Sequelae 1

1

1

2

3

4

2

3

4

2

3

4

1

2

3

4

1

2

3

4

Figure 23-2

Ferriman-Gallwey system to evaluate for hirsutism. From: Hatch R, Rosenfield RL, Kim MH, et al.: Hirsutism: Implications, etiology, and management. Am J Obstet Gynecol 1981;140:815–830. Adapted from Ferriman D, Gallwey JD: Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961;21:1440– 1447.

A study of adult women with PCOS revealed that 43% met criteria for the metabolic syndrome. Participants with the metabolic syndrome and PCOS, compared with those with PCOS only, had higher free testosterone and lower SHBG levels.

Cardiovascular disease is more prevalent in adult women with than without PCOS due to many of the manifestations discussed previously (i.e., obesity, central body fat distribution, Type 2 diabetes mellitus, and dyslipidemia). Women with PCOS are also at increased risk for hypertension and elevated levels of plasminogen activator inhibitor 1 (PAI-1), which inhibits fibrinolysis and has been associated with myocardial infarction. Although epidemiological data are limited, prospective studies have demonstrated a four-fold risk of hypertension and seven-fold risk of myocardial infarction in women who had undergone ovarian wedge resection for PCOS ­compared with control subjects without PCOS. Infertility is a common presenting complaint of adult women with previously undiagnosed PCOS, and PCOS is the most common cause of anovulatory infertility. In addition to the difficulty with conception, women with PCOS are at increased risk for miscarriage, both after spontaneous and induced ovulation. Endometrial cancer is associated with chronic anovulation, obesity, and hyperinsulinemia, all of which are features of PCOS. Studies have not demonstrated consistently that women with PCOS are at higher risk of breast or ovarian cancer. Low self-esteem and poor body image during adolescence have been associated with the clinical manifestations of PCOS. Adolescents with PCOS also report lower health-related quality of life and more concerns about fertility than adolescents without PCOS.

Laboratory and Radiographic Findings There is no one laboratory or radiographic study that is pathognomonic for PCOS. The most sensitive test for the

170 Adolescent Medicine: The Requisites in Pediatrics

detection of hyperandrogenemia is the serum free testosterone level, but it is not specific for PCOS. A small proportion of patients with PCOS have mild to moderate elevations of serum dehydroepiandrosterone sulfate (DHEA-S), with normal levels of serum total and free testosterone. Other laboratory findings consistent with PCOS include elevated levels of serum LH and an LH:FSH ratio greater than 2.5:1. Serum concentrations of total and free estradiol are within the normal range for the early or mid follicular phase of the menstrual cycle. However, the pattern of estradiol secretion does not demonstrate the preluteal surge seen a normal ovulatory cycle. Insulin resistance is manifested by an increase in the ratio of fasting insulin:glucose levels and by an abnormal oral glucose tolerance test. However, the cut-points that differentiate insulin resistance from normal and frank diabetes mellitus remain controversial due to physiological fluctuation in insulin levels and lack of a standardized insulin assay. Polycystic ovaries (see Definitions, above) are seen more commonly on pelvic ultrasound in adults than adolescents with PCOS. However, the finding does not confirm PCOS and its absence does not exclude PCOS. Polycystic ovaries can also be seen in 21-hydroxylase deficiency, Cushing syndrome, androgen-secreting tumors, exogenous androgen use, insulin resistance, hyperprolactinemia, use of medications such as valproate, and in 25% of women with normal menstrual cycles.

Diagnosis Two sets of diagnostic criteria for PCOS are in common use (Table 23-2). The 1990 National Institutes of

Health (NIH) criteria require oligo- or anovulation plus clinical and/or biochemical evidence of hyperandrogenism. The 2003 Rotterdam criteria require either both of these criteria or one of these criteria plus ultrasound evidence of polycystic ovaries. Both the NIH and Rotterdam criteria require the exclusion of other causes of hyperandrogenism, such as androgensecreting tumors and congenital adrenal hyperplasia. As noted in Box 23-1, the Rotterdam Consensus Conference also produced criteria for the diagnosis of metabolic syndrome specifically in women with PCOS. The major conditions that comprise the differential diagnosis of PCOS include those associated with increased ovarian or adrenal production of androgens. Testosterone excess alone is usually ovarian; DHEA and/or DHEA-S excess is adrenal; and androstenedione excess may be adrenal or ovarian. DHEA and DHEA-S do not have much androgenic activity but are converted first to androstenedione and then to testosterone, both of which do have androgenic activity. Young women with oligomenorrhea or secondary amenorrhea, accompanied by clinical signs of hyperandrogenemia, are likely to have PCOS. Nonclassic congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency often is difficult to distinguish clinically from PCOS. Idiopathic hirsutism occurs in females with normal menses, normal androgen levels, and no identifiable cause for the hirsutism. Signs of virilization (see Definitions, discussed previously) or higher androgen levels than are typically seen in PCOS should prompt an evaluation for an androgen-secreting tumor. Cushing syndrome is a rare cause of hyperandrogenism and usually presents with clinical signs and symptoms that are not characteristic of PCOS, such as dorsal fat pad, telangiectasias, moon facies, and muscle atrophy.

Table 23-2  Diagnostic Criteria for PCOS NIH1 Criteria

Rotterdam Criteria

Oligo- or anovulation

+

±

Clinical and/or biochemical signs of hyperandrogenism

+

±

Ultrasound evidence of polycystic ovaries

−

±

Exclusion of other causes of hyperandrogenism

+

+

Box 23-1 Diagnostic Criteria for the

Metabolic Syndrome in Women with PCOS

2 of 3 required

+, required; −, not required; ±, required option. 1 NIH, National Institutes of Health. Adapted from: The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81(1):19–25.

Waist   circumference Triglycerides HDL-cholesterol Blood pressure Oral glucose   tolerance test

> 88 cm ≥ 150 mg/dl < 50 mg/dl ≥ 130/≥ 85 mmHg Fasting glucose 110–126 mg/dl and/   or 2-hour glucose 140–199 mg/dl

Adapted from:The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81(1):19–25.

Polycystic Ovary Syndrome 171



Evaluation The history of an adolescent with suspected PCOS should include the ages of menarche, pubarche, and thelarche; menstrual pattern; development of hirsutism and acne; and weight changes. Family history should be reviewed for first- and second-degree relatives with PCOS, menstrual irregularity, hirsutism, infertility, diabetes mellitus, hyperlipidemia, and cardiovascular disease. Physical examination should include blood pressure, height, weight, calculation of body mass index, body habitus, and Tanner staging. Skin should be examined for acne, hirsutism, frontal balding, and acanthosis nigricans. If hirsutism is present, it is helpful to quantify it by the Ferriman-Gallwey system (Table 23-1 and Figure 23-2) so that response to treatment can be monitored. The thyroid should be examined because hypothyroidism may contribute to obesity, and hypo- or hyperthyroidism may cause menstrual irregularity (Chapter 22). Gala­c­ torrhea on breast examination would suggest hyperprolactinemia as a cause of amenorrhea. External genitalia should be examined for pattern of pubic hair growth and clitoral size. Signs of virilization should raise concern for an androgen-secreting tumor. Box 23-2 outlines the laboratory evaluation for suspec­ ted PCOS (see Pathophysiology, previous discussion). A serum total testosterone level > 150 ng/dl or a serum DHEA-S level > 700 μg/d suggests an androgen-secreting tumor and warrants abdominal and pelvic imaging.

Box 23-2 Laboratory Evaluation for

Suspected PCOS

Serum l l l l l l l

Testosterone: total and free Sex hormone-binding globulin (SHBG) Follicle-stimulating hormone (FSH) Luteinizing hormone (LH) Thyroid-stimulating hormone (TSH) Dehydroepiandrosterone sulfate (DHEA-S) 17-hydroxyprogesterone (if 21-hydroxolase deficiency is suspected)

Urine l l

Pregnancy test Free cortisol or dexamethasone suppression test (if Cushing syndrome is suspected)

Radiological l

Pelvic ultrasound to evaluate for polycystic ovaries

Adapted from:The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81(1):19–25.

A diagnosis of 21-hydroxylase deficiency is excluded by early morning 17α-hydroxyprogesterone (17-OHP) serum levels < 200 ng/dl and confirmed by levels > 1000 ng/dl. Intermediate levels should be explored further by measuring serum 17-OHP 60 minutes after the parenteral administration of adrenocorticotropic hormone (ACTH) 0.25 mg. A defect in 21-hydroxylase activity decreases the conversion of 17-OHP to 11-deoxycortisol, resulting in increased levels of 17-OHP. Adult-onset 21-­hydroxylase deficiency is one of the most common autosomal recessive diseases, occurring in 1–2% of the non-Jewish Caucasian population, and 4% of Ashkenazic Jews. It is controversial whether testing should be performed routinely in populations in which the frequency of CAH is low. Routine screening should probably be performed in populations at high risk for CAH. In patients with clinical manifestations of Cushing syndrome, free cortisol should be measured with a 24-hour urine collection, or an overnight dexamethasone suppression test should be performed. Cushing syndrome is unlikely if the 24-hour urinary cortisol is < 50 μg (normal values may vary depending on the laboratory) or the morning serum cortisol level after dexamethasone is < 5 μg/d. In adolescents with PCOS, testing for insulin resistance and hyperlipidemia should be considered, although their clinical utility is not well established, as noted previously. Tests used to screen for insulin resistance include fasting insulin and glucose levels and a 2-hour oral glucose tolerance test. Insulin resistance is likely in an adolescent if the fasting levels of glucose and insulin yield a glucose: insulin ratio < 7. The standard use of pelvic ultrasonography to establish the diagnosis of PCOS remains controversial, although it is recommended by the Rotterdam ESHRE/ ASRM-Sponsored PCOS Consensus Workshop Group. It can be particularly helpful in patients who do not meet NIH criteria for the diagnosis.

Management The short-term goals in the management of PCOS are to improve hirsutism, acne (Chapter 15), and menstrual regularity (Chapter 22). Long-term goals include the prevention or management of obesity (Chapter 11), diabetes mellitus (Chapter 13), and cardiovascular disease (Chapters 12, 14).

Combined Estrogen/Progestin or ProgestinOnly Therapy A combination oral contraceptive pill (OCP) containing an estrogen and progestin is first-line therapy for most adolescents with PCOS. The OCP decreases LH secretion;

172 Adolescent Medicine: The Requisites in Pediatrics

decreases ovarian and adrenal production of androgens; increases serum levels of SHBG; and inhibits 5α-reductase effects in the skin, leading to lower dihydrotestosterone. Reductions in androgen levels occur within the first month of therapy and do not appear to differ significantly by formulation. Minor, and usually transient, side effects include nausea, breast tenderness, headache, and irregular vaginal bleeding. Adolescents who begin the OCP should be evaluated regularly for side effects, response to treatment, adherence, and screening for sexually transmitted infections (STIs) if sexually active. More serious side effects of the OCP include hypertension and venous thromboembolism (VTE). Although the absolute risk of VTE in adolescents is very low, those with a strong family history of VTE should be evaluated for an inherited thrombophilic disorder before beginning the OCP. This evaluation includes a thrombotic profile, including testing for Factor V Leiden mutation, in the affected family members and/or the adolescent. Progestin-only therapy is an alternative to the OCP for adolescents with contraindications to estrogen use (e.g., active liver disease, systemic lupus erythematosus, migraine with aura, thrombophilic disorders). Options include depot medroxyprogesterone acetate (DepoProvera) 150 mg intramuscularly every 90 days, or medroxyprogesterone acetate (Provera) 10 mg orally every day for 12–14 days monthly. Adverse effects include irregular bleeding and weight gain. In patients with PCOS, progestin-only therapy is not as effective as the OCP for the management of hirsutism, acne, or irregular menses.

Antiandrogens Adolescents with hirsutism that does not improve with OCP may benefit from the addition of an antiandrogen. In the United States, spironolactone is the most commonly prescribed antiandrogen for the treatment of PCOS. It may be prescribed initially as 25 mg orally twice daily, then increased to a maximum of 100 mg twice daily. Spironolactone must be prescribed with an effective contraceptive agent in sexually active females because of its potential interference with sexual differentiation of the male fetus. Side effects include mild diuresis, rash, gastrointestinal symptoms, headache, menstrual irregularity, and hyperkalemia. Electrolytes and renal function should be checked periodically. Renal failure and hyperkalemia are contraindications to the use of spironolactone. Cyproterone acetate is used outside the United States but has not been approved by the U.S. Food and Drug Administration (FDA). Flutamide has also been prescribed, but its association with hepatocellular toxicity limits its use. Many patients will not experience complete resolution of hirsutism even with an antiandrogen. Waxing,

bleaching, electrolysis, or laser hair removal may be used adjunctively. Eflornithine hydrochloride (Vaniqa) may be helpful, but few data are available in women with PCOS. It is available as a topical 13.9% cream and is applied as a thin layer to affected areas of the face twice daily.

Insulin-Sensitizing Agents Insulin-sensitizing agents (e.g., metformin) are under active investigation for the treatment of PCOS and associated infertility. Although the FDA has not approved their use exclusively for PCOS, metformin is used commonly in the United States and elsewhere for this purpose. A recent ­survey of pediatric endocrinologists revealed that 30% consider metformin for all adolescents with PCOS and 68% consider it for obese adolescents with PCOS. Metformin is an oral biguanide that interferes with hepatic gluconeogenesis; increases the number of insulin receptors; reduces serum insulin and androgen levels; and increases SHBG levels. Studies have demonstrated improvements in menstrual regularity, fertility, and lipid profiles in women with PCOS, regardless of the presence or absence of obesity and insulin resistance. In obese women, metformin plus the OCP appears to improve body mass index, waist-to-hip ratio, and insulin sensitivity. The literature on metformin use in adolescents is far more limited than that in adults, but the results are encouraging. Studies in preadolescent girls with precocious puberty suggest that insulin-sensitizing agents may prevent the progression to PCOS. The most common side effects of metformin are nausea, vomiting, abdominal pain, and diarrhea. A rare but serious side effect is lactic acidosis, and its use is contraindicated in patients at increased risk for acidosis (e.g., renal insufficiency, congestive heart failure, dehydration). Therapy should be suspended temporarily in patients who are acutely ill or undergoing radiographic procedures involving the intravascular administration of iodinated contrast materials. Metformin is available in an oral tablet (500 mg, 850 mg, 1000 mg) and an extendedrelease oral tablet (500 mg, 750 mg, 1000 mg). Dosage ranges for PCOS have not been established, but the usual starting dose is 500–750 mg daily with weekly increases of 500 mg daily to a maximum of 2000 mg daily. Renal and hematological function should be assessed before ­initiation and annually thereafter.

Lifestyle Changes, Education, and Counseling Weight reduction, through caloric restriction and exercise, should be a focus of management in obese adolescents with PCOS. Even moderate weight loss can significantly improve the hormonal and metabolic abnormalities

Polycystic Ovary Syndrome 173



a­ ssociated with PCOS. Referral to a dietician or a comprehensive weight management program may be helpful. The complexity of PCOS often causes confusion for adolescents and parents. Office-based education, counseling about short- and long-term effects, written materials, and on-line resources should be reviewed frequently. It is especially important to refer adolescents who are struggling with self-esteem for supportive counseling. Some adolescents with PCOS perceive themselves as infertile. Clinicians should reassure them that many women with PCOS are not infertile, that effective treatment is available for women with PCOS who have difficulty conceiving, and that it is important for them to use effective contraception if they do not desire pregnancy.

 l

l

l

l

l

Major Points

b

PCOS is a common disorder that usually presents during adolescence and is characterized by hyperandrogenism, anovulation, and hyperinsulinemia. Clinicians must distinguish physiological anovulatory cycles from PCOS and differentiate PCOS from other causes of hyperandrogenism. Systemic medications that may be helpful in the management of PCOS include the OCP, spironolactone, and metformin. Weight management and exercise are essential in obese adolescents with PCOS, as weight loss may improve signs of hyperandrogenism and menstrual irregularity and may prevent the development of Type 2 diabetes and cardiovascular disease. Long-term, prospective studies are needed to identify those management strategies that can safely and effectively reduce the risk of infertility, diabetes, and cardiovascular disease in young women with PCOS.

Azziz R, Woods KS, Reyna R, et al.: The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab 2004;89:2745–2749. Balen AH, Conway GS, Kaltsas G, et al.: Polycystic ovary syndrome: The spectrum of the disorder in 1741 patients. Hum Reprod 1995;10:2107–2111. Buggs C, Rosenfield RL: Polycystic ovary syndrome in adole­ scence. Endocrinol Metab Clin North Am 2005;34:677–705, x. Coviello AD, Legro RS, Dunaif A: Adolescent girls with polycystic ovary syndrome have an increased risk of the metabolic syndrome associated with increasing androgen levels independent of obesity and insulin resistance. J Clin Endocrinol Metab 2005 Oct 25;[Epub ahead of print]. Available from: http://www. endojournals.org. Accessed June 4, 2007.  2006;91:492–497. De Leo V, la Marca A, Petraglia F: Insulin-lowering agents in the management of polycystic ovary syndrome. Endocr Rev 2003;24:633–667. Dunaif A: Hyperandrogenic anovulation (PCOS): A unique disorder of insulin action associated with an increased risk of non-insulin-dependent diabetes mellitus. Am J Med 1995;98(1A):33S–39S. Dunaif A: Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis. Endocr Rev 1997;18:774–800. Dunaif A, Finegood DT: Beta-cell dysfunction independent of obesity and glucose intolerance in the polycystic ovary syndrome. J Clin Endocrinol Metab 1996;81:942–947. Dunaif A, Segal KR, Shelley DR, et al: Evidence for distinctive and intrinsic defects in insulin action in polycystic ovary syndrome. Diabetes 1992;41:1257–1266. Dunaif A, Thomas A: Current concepts in the polycystic ovary syndrome. Ann Rev Med 2001;52:401–419. Dunaif A, Xia J, Book CB, et al: Excessive insulin receptor serine phosphorylation in cultured fibroblasts and in skeletal muscle. A potential mechanism for insulin resistance in the polycystic ovary syndrome. J Clin Invest 1995;96:801–810. Ferriman D, Gallwey JD: Clinical assessment of body hair growth in women. J Clin Endocrinol Metab 1961;21:1440–1447. Franks S, McCarthy M: Genetics of ovarian disorders: Polycystic ovary syndrome. Rev Endocr Metab Disord 2004;5:69–76.

Bibliography Allen HF, Mazzoni C, Heptulla RA, et al.: Randomized controlled trial evaluating response to metformin versus standard therapy in the treatment of adolescents with polycystic ovary syndrome. J Pediatr Endocrinol Metab 2005;18:761–768. American Association of Clinical Endocrinologists Polycystic Ovary Syndrome Writing Committee: American Association of Clinical Endocrinologists position statement on metabolic and cardiovascular consequences of polycystic ovary syndrome. Endocr Pract 2005;11:126–134. Apridonidze T, Essah PA, Iuorno MJ: Prevalence and charac­ teristics of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab 2005;90:1929–1935.

Ibanez L, Dimartino-Nardi J, Potau N, et al.: Premature adrenarche—Normal variant or forerunner of adult disease? Endocrine Reviews 2000;21:671–696. Ibanez L, Valls C, Marcos MV, et al.: Insulin sensitization for girls with precocious pubarche and with risk for polycystic ovary syndrome: Effects of prepubertal initiation and postpubertal discontinuation of metformin treatment. J Clin Endocrinol Metab 2004;89:4331–4337. Knochenhauer ES, Key TJ, Kahsar-Miller M, et al.: Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: A prospective study. J Clin Endocrinol Metab 1998;83:3078–3082. Lord JM, Flight IH, Norman RJ: Metformin in polycystic ovary syndrome: Systematic review and meta-analysis. BMJ 2003;327:951–953.

174 Adolescent Medicine: The Requisites in Pediatrics Mather KJ, Kwan F, Corenblum B: Hyperinsulinemia in poly­ cystic ovary syndrome correlates with increased cardiovascular risk independent of obesity. Fertil Steril 2000;73:150–156. Nobels F, Dewailly D: Puberty and polycystic ovarian syndrome: The insulin/insulin-like growth factor I hypothesis. Fertil Steril 1992;58:655–666. Rosenfield RL: Ovarian and adrenal function in polycystic ovary syndrome. Endocrinol Metab Clin North Am 1999;28:265–293. Rosenfield RL, Ghai K, Ehrmann DA, et al.: Diagnosis of the polycystic ovary syndrome in adolescence: Comparison of adolescent and adult hyperandrogenism. J Pediatr Endocrinol Metab 2000;13(Suppl 5):1285–1289. Stadtmauer L, Oehninger S: Management of infertility in women with polycystic ovary syndrome: A practical guide. Treat Endocrinol 2005;4:279–292. Stein IR, Leventhal ML: Amenorrhea associated with bilateral polycystic ovaries. Am J Obstetr Gynecol 1935;29:181–191.

The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group: Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 2004;81:19–25. van Hooff MH, Voorhorst FJ, Kaptein MB, et al.: Endocrine features of polycystic ovary syndrome in a random population sample of 14–16 year old adolescents. Hum Reprod 1999;14: 2223–2229. Villa P, Di Sebastiano F, Rossodivita A, et al: Which treatment options should be used in adolescents with polycystic ovary syndrome? J Pediatr Endocrinol Metab 2004;17:705–710. Zawadski JK, Dunaif A: Diagnostic criteria for polycystic ovary syndrome: Towards a rational approach. In Dunaif A, Givens JR, Haseltine F (eds): Polycystic Ovary Syndrome. Boston, Blackwell Scientific, 1992, pp. 377–384.

24

C h A pter

Introduction Definitions Lower Abdominal Pain Adnexal Torsion Epidemiology and Pathophysiology Evaluation Management

Functional Ovarian Cysts Epidemiology and Pathophysiology Evaluation and Management

Disorders of the Female Pelvis Lesley L. Breech, MD

adult. An adnexal mass is much more likely to be caused by a uterine fibroid or gynecological malignancy in an adult than an adolescent. It therefore is important to understand the epidemiology of pelvic disorders and to collaborate with gynecological consultants on the evaluation and management of these problems in adolescents. This chapter begins with an overview of acute and chronic pelvic pain. It then discusses adnexal torsion, functional ovarian cysts, endometriosis, congenital anomalies of the reproductive tract, and ovarian tumors.

Endometriosis Epidemiology Pathophysiology Evaluation Management

Wolffian Duct Remnants Epidemiology and Pathophysiology Evaluation and Management

Congenital Anomalies of the Uterus, Fallopian Tubes,   and Vagina Epidemiology and Pathophysiology Evaluation Management

Ovarian Tumors Epidemiology and Pathophysiology Evaluation and Management

Introduction Disorders of the female pelvis typically present with lower abdominal pain, a pelvic mass, or abnormal vaginal bleeding. Although the differential diagnoses for these presenting problems overlap in adolescents and adults, the leading causes change with advancing age. For example, pelvic pain is much more likely to be caused by pelvic inflammatory disease or adnexal torsion in an adolescent than an

Definitions Adnexa: Region adjacent to the uterus that includes the ovary, fallopian tube, and associated structures. Adnexal torsion: Excessive rotation of the infundibulopelvic ligament around its axis with impairment of flow through the ovarian artery and vein that supply the ovary and fallopian tube (Figure 24-1). Chronic pelvic pain: In adults, noncyclical pain lasting at least 3 months or cyclical pain recurring over at least 6 months, either of which interferes with normal activities. In children, three or more bouts of pain severe enough to affect activities over at least 3 months. Corpus luteum cyst: A collection of yellowish fluid within the ovary that forms when the corpus luteum does not involute after ovulation and continues to increase to a usual diameter of 3–8 cm. Dermoid cyst: Mature, benign, cystic teratoma that can contain sebum, hair, and teeth. Endometrioma: Benign growth of endometrial tissue outside the uterine cavity that is often described as a “chocolate cyst” on gross examination and may cause elevation of the serum CA 125 level. Endometriosis: Condition in which endometrial glands and stroma are found outside the endometrial cavity of the uterus. 175

176 Adolescent Medicine: The Requisites in Pediatrics

Box 24-1  Differential Diagnosis

of Acute Pelvic Pain in Adolescent Females

l l l l l l l l l l

Ectopic pregnancy Pelvic inflammatory disease Abortion Ruptured ovarian cyst Adnexal torsion Mittelschmerz Appendicitis Renal stone Urinary tract infection Obstructed viscus

Figure 24-1 Laparoscopic view of torsed ovarian blood supply.

Box 24-2 Differential Diagnosis of Follicular cyst: A thin-walled collection of fluid within the ovary that forms when the follicle does not rupture to release an ovum and continues to increase to a usual diameter of 3–8 cm. Leiomyoma ( fibroid): Benign growths arising from the uterine smooth muscle that are most likely to cause symptoms among women in their late 30s and 40s. Müllerian ducts: Normally regress in the male fetus and form the fallopian tubes, uterus, and upper vagina in the female fetus. Pelvic inflammatory disease (PID): Polymicrobial infection of the upper genital tract, usually beginning with Neisseria gonorrhoea or Chlamydia trachomatis and often involving additional organisms, such as anaerobic and facultative bacteria (Chapter 26). Serous and mucinous cystadenomas: Benign ovarian tumors that range in diameter from 5–20 cm can be uni- or multilocular and tend to recur if not resected. Teratoma: Immature to well-differentiated germ cell tissue that is normally foreign to the anatomical site in which it is found. Wolffian ducts: Paired mesonephric ducts that normally regress in the female fetus and form the epididymis, vas deferens, seminal vesicles, and ejaculatory ducts in the male fetus.

Lower Abdominal Pain Pelvic and lower abdominal pain peaks in prevalence during adolescence and is three times more common in females than males. The differential diagnoses for acute and chronic, recurrent pain are shown in Boxes 24–1 and 24–2, respectively. The evaluation of acute pelvic pain in a female of reproductive age must include pregnancy testing. Ectopic preg-

Chronic, Recurrent Pelvic Pain in Adolescent Females

l l l l l l l l l

Functional pain Endometriosis Pelvic inflammatory disease Constipation Irritable bowel syndrome Lactose intolerance Inflammatory bowel disease Myofascial (i.e., abdominal wall) strain Obstructed viscus

nancy, which typically presents with pain and bleeding, remains a leading cause of maternal mortality in the United States. If ectopic pregnancy is diagnosed or strongly suspected, emergency surgery is indicated. Clinical suspicion should always be high in a patient with pelvic pain, bleeding, positive urine or serum testing for beta-human chorionic gonadotropin (beta-HCG), and the absence of an intrauterine gestational sac on transvaginal ultrasonography. Other factors that support the diagnosis include history of prior ectopic pregnancy, PID, pelvic surgery, or intrauterine device; missed menstrual periods; symptoms of pregnancy; and fullness in the cul-de-sac or adnexa. Chronic or recurrent abdominal pain affects up to 5% of adolescent females. The difficulty establishing a diagnosis often leads to anxiety and frustration for patients, families, and clinicians.  Although the differential diagnosis is extensive and the evaluation can be lengthy, 95% of cases in one series had no identifiable organic pathology (i.e., functional pain). Factors associated with functional pain include environmental stress, absence of pain during sleep, variable location or description of the pain, family history of unexplained abdominal pain, and absence of weight loss.

Disorders of the Female Pelvis 177



The evaluation of an adolescent with acute or chronic pelvic pain should include a menstrual and sexual history; evaluation of growth and weight change; skin and mucosal examinations for rash or ulceration; joint examination for arthritis (e.g., inflammatory bowel disease); abdominal examination; rectal examination with testing for occult blood; and pelvic examination as tolerated.  At a minimum, the patency of the reproductive outflow tract should be verified by inserting a cotton-swabbed applicator into the vagina. Whenever possible, a vaginal-abdominal or rectoabdominal examination should be performed to palpate the cervix, uterus, and adnexae. However, the pelvic examination should not be considered mandatory in the young, virginal adolescent. If the bimanual examination is inadequate or indeterminate, pelvic ultrasonography is indicated to help define the pelvic anatomy. Laboratory evaluation should be guided by the findings on history and physical examination but generally should include urine testing for beta-HCG, complete blood cell count, erythrocyte sedimentation rate or serum C-reactive protein, and urinalysis.

Adnexal Torsion Adnexal torsion occurs when the vasculature supplying the ovary and tube undergoes excessive rotation about its axis, producing a mechanical impairment to flow (Figure 24-1). Both the ovarian artery and vein are affected within the infundibulopelvic ligament. Venous flow is the first to be compromised due to the compressibility of the lower-pressure vessels. As venous congestion progresses, edema of the ovarian tissue stretches the ovarian capsule to capacity. The resulting high-pressure state within the ovary eventually compromises arterial flow, leading to ischemia, hemorrhage, and finally necrosis.

Epidemiology and Pathophysiology Adnexal torsion is responsible for 3% of acute gynecological complaints. It is most likely to occur in adolescents and young adult women and is usually associated with underlying benign pathology such as cystic teratoma, tubal or follicular cyst, and serous or mucinous cystadenoma. Factors associated with torsion include excessively mobile mesovaria or fallopian tubes, congenitally long pelvic ligaments, tubal spasm, abrupt changes in intra-abdominal pressure, sudden changes in motion, and genetic predisposition.

Evaluation The preoperative diagnosis of adnexal torsion is often difficult due to the overlap in symptoms and physical findings with other conditions. It therefore is ­imperative

to maintain a high index of suspicion when evaluating adolescent females with acute-onset pelvic pain. Torsion usually presents with unilateral pain, more commonly on the right than left. Nausea and vomiting occur in 70–80% of patients with torsion, fever in 20%, and a palpable mass in 20–36%. Findings on pelvic ultrasound may include vascular engorgement and enlargement of the tube and/or ovary; stromal edema; and free fluid in the pelvis. However, because ultrasonography neither confirms nor excludes torsion, laparoscopy is indicated if the clinical suspicion of torsion is high.

Management The management of adnexal torsion has become more conservative over the last decade. For many years, the standard treatment involved oophorectomy rather than untwisting or detorsing the involved reproductive structures. The rationale behind the previous recommendation of oophorectomy stemmed both from fears regarding the risk of malignancy associated with the torsed ovary and the risk of thrombus release into the systemic circulation after untwisting the ovarian vasculature. Ovarian malignancies have been reported in adult women with torsion but not in children or adolescents, and many case series have found no cases of thromboembolus release after detorsion. In the past, torsed adnexae that appeared grossly necrotic were assumed to be damaged irreversibly. It now is recognized that clinical inspection does not reliably differentiate reversible ischemia from irreversible necrosis. The recommended procedure for adnexal torsion therefore is detorsion without removal of the involved structures.

Functional Ovarian Cysts Epidemiology and Pathophysiology Functional, or physiological, ovarian cysts are benign, encapsulated fluid collections within the ovary. The most common type is the follicular cyst, which typically ranges in diameter from 3–8 cm and resolves spontaneously in 4–8 weeks. Corpus luteum cysts (Figure 24-2) are similar in size but more likely to rupture than follicular cysts. Rupture of a corpus luteum cyst tends to occur late in the menstrual cycle and is associated with sexual intercourse, exercise, palpation, and abdominal trauma. Factors associated with functional ovarian cysts include smoking and underlying polycystic ovary syndrome (Chapter 23). Oral contraceptive pills (OCPs) and depot medroxyprogesterone acetate have been shown to decrease the likelihood of

178 Adolescent Medicine: The Requisites in Pediatrics

pelvic ultrasounds. If pain is severe or torsion is suspected, diagnostic laparoscopy is the procedure of choice. Intraoperatively, the decision about whether to drain or resect a cystic structure can be difficult. A simple follicular cyst requires only drainage. A serous cystadenoma, which cannot be distinguished grossly from a follicular cyst, can recur and requires complete resection, with preservation of ovarian tissue. Hormonal suppression of new cyst formation with the OCP, contraceptive transdermal patch, or contraceptive vaginal ring is usually recommended for 3–6 months following drainage or resection.

Endometriosis Figure 24-2 Laparoscopic view of a left ovarian corpus luteal cyst.

functional cyst formation but do not hasten regression of an existing cyst. The likelihood that a functional cyst will regress decreases as its size increases. More than 80% of cysts 4 cm or less in diameter regress, compared with less than 30% of those 6–8 cm in diameter. Pain is also a function of cyst size. As the cyst diameter increases, stretch on the overlying ovarian cortex and capsule elicits pain. Rupture of the cyst into the peritoneal cavity can produce inflammation, peritonitis, and acute pain, particularly if there is associated hemoperitoneum. It is important to differentiate functional ovarian cysts from normal follicles. The average follicle at the time of ovulation is painless, 2.5 cm in diameter, and readily visible on pelvic ultrasound. Interpreting the follicle as an abnormal mass or a likely source of pain can lead to unnecessary intervention and can delay other evaluation.

Evaluation and Management The history should seek to identify the onset of the cyst relative to the menstrual cycle, the characteristics of the pain, and its effect on daily activities. Physical examination can help determine cyst size, but pelvic ultrasound usually is indicated for more accurate assessment of size and consistency. Indications for surgical intervention include cyst rupture with hemodynamic instability or severe, persistent pain; physical examination findings of persistent peritonitis; rapid increase in the diameter of a large cyst; and failure of a cyst to regress over several months’ observation. Most ovarian cysts during adolescence resolve spontaneously over the course of several menstrual cycles and can be monitored by serial pelvic examinations and/or

Endometriosis is a condition in which endometrial glands and stroma are found outside the uterine ­cavity. Severe or progressive dysmenorrhea is the presenting symptom in 64–94% of adolescents with endo­ metriosis. Adults are more likely than adolescents to present with infertility and dyspareunia. Other common symptoms include nausea and vomiting during menses.

Epidemiology Endometriosis has been reported in 19–73% of adolescents undergoing laparoscopy for chronic pelvic pain and in 50–70% of adolescents with pelvic pain that does not respond to estrogen-progestin therapy and nonsteroidal anti-inflammatory drugs (NSAIDs). Congenital anomalies occur in 5–6% of patients with endometriosis and include imperforate hymen, vaginal septum, hematocolpos, hematometra, and an obstructed uterine horn.

Pathophysiology There are several hypotheses regarding the etiology of endometriosis. Sampson hypothesized that retrograde menses with peritoneal seeding of endometrial tissue explains the tendency for endometriosis to involve the dependent portions of the pelvis. The theory is also supported by the known association of endometriosis with Müllerian anomalies and outflow tract obstruction. Endometriosis appears to regress in patients with surgically corrected outflow tract obstruction, whereas it persists in those without structural anomalies. Meyer theorized that embryologically totipotential cells undergo metaplastic transformation into functioning endometrium. Halban’s theory involves vascular or lymphatic spread due to a deficiency in cell-mediated immunity that inhibits adequate clearing of endometrial cells from aberrant locations.

Disorders of the Female Pelvis 179



Evaluation The diagnosis of endometriosis depends on the gross visualization of endometrial implants within the pelvis or the microscopic finding of endometrial tissue on a peritoneal biopsy specimen. The diagnosis cannot be established by history, physical examination, or imaging studies. However, because NSAIDs and combined estrogen-progestin therapy constitute initial management for both primary dysmenorrhea (Chapter 22) and endometriosis, laparoscopy is reserved for those patients who have persistent pain after several months of treatment. The typical lesions of endometriosis in adolescents may differ from those in adults (Figure 24-3). It therefore is important that a gynecologist familiar with the surgical diagnosis and management of endometriosis in adolescents performs the laparoscopy. In addition to recognizing the lesions of endometriosis, the surgeon should be prepared to excise or ablate lesions that are contributing to pain and to biopsy peritoneal lesions that suggest endometriosis if the diagnosis cannot be established on gross examination.

Management As noted above, the first-line treatment of adolescents with suspected or documented endometriosis involves the use of NSAIDs and combination estrogen-progestin therapy delivered as the combination OCP, transdermal patch, or vaginal ring. Most clinicians advocate the continuous use of OCPs to minimize the number of days with bleeding. A randomized control trial comparing a 28-day regimen with a 49-day regimen found that the total bleeding days were fewer with the 49-day regimen and that there was no significant difference in the number of days with spotting.

Progestin-only protocols delivered orally as medroxyprogesterone or intramuscularly as depot medroxyprogesterone acetate have been used for the treatment of endometriosis, but studies suggest that these regimens are less effective in managing pain and less well-tolerated than combined estrogen-progestin regimens. In addition, depot medroxyprogesterone acetate continued beyond 2 years has been shown to decrease bone density. If pain persists on combined estrogen-progestin therapy and NSAIDs, laparoscopy is indicated to establish the diagnosis and to surgically remove or destroy visible lesions of endometriosis. Following surgery, hormonal suppression should continue until pregnancy is desired to minimize disease progression, pain, adhesions, and infertility. Many patients with disease severe enough to warrant surgery require postoperative suppression with a gonadotropin-releasing hormone agonist (GnRH-a) to establish a hypoestrogenic state. Although these agents are highly effective in the treatment of endometriosis, their use in patients younger than 18 years is associated with a 5% loss in trabecular bone mineral density after 6 months of therapy. It therefore is recommended that adolescents attempt combination estrogen-progestin therapy again after 6 months of treatment with a GnRH-a. Those adolescents who are refractory to combination estrogenprogestin should be managed with a GnRH-a plus addback hormonal therapy to preserve bone density. The add-back is usually administered orally as conjugated estrogen/medroxyprogesterone 0.625/2.5 mg daily. Although surgery is effective in diminishing the pain of endometriosis, radical surgical procedures such as oophorectomy and hysterectomy should be avoided during adolescence because of the recurrent nature of the disease. In a double-blinded, randomized trial of adults with endometriosis, 63% of subjects managed with laser vaporization compared with 23% of control subjects reported significant pain relief at 6 months, and 90% of those in the treatment arm had continued pain relief at 1 year.

Wolffian Duct Remnants Epidemiology and Pathophysiology

Figure 24-3 Intraoperative view of classic-appearing lesions of endometriosis in an adolescent.

During normal embryonic development, the Wolffian or paired mesonephric ducts form the reproductive organs in males and degenerate in females. Remnants of the Wolffian duct system in females may be retained within the leaves of the broad ligament between the uterus, fallopian tube, and ovary. With puberty, these remnants may elongate and become distended with clear fluid secretions (Figure 24-4).  Although the collections may reach sizes as large as 30 cm (Figure 24-5), they usually are painless because of their location outside the Müllerian and

180 Adolescent Medicine: The Requisites in Pediatrics

Resecting the distended structures without damaging the functional Müllerian structures can be difficult because the fallopian tube may stretch and surround a cyst within the broad ligament. Open abdominal laparotomy has historically provided excellent visualization and circumferential palpation of the fallopian tube. Laparoscopy is less invasive but does not allow palpation and thus requires meticulous dissection to save normal reproductive structures. Additional surgical challenges may be involved if the cyst retains any communication with the functional urological system.

Congenital Anomalies of The Uterus, Fallopian Tubes, and Vagina Figure 24-4 Laparoscopic view of a Wolffian duct cyst within the leaves of the right broad ligament.

ovarian structures. They may be discovered coincidentally, during evaluations of bloating or increasing abdominal girth, or through their association with adnexal torsion.

Evaluation and Management Surgical intervention is the definitive treatment for distended Wolffian duct remnants. Pelvic ultrasonography should be performed preoperatively to determine whether the cystic structure is separate from the ovary.

Epidemiology and Pathophysiology The fallopian tubes, uterus, and upper vagina develop from the Müllerian ducts, and the distal vagina develops from the urogenital sinus. The ovaries develop independently from both of these systems. Consequently, most women with congenital anomalies of the uterus, tubes, or vagina have normal ovarian anatomy and function. In contrast, because the development of the female reproductive tract and urinary tract are intertwined, women with anomalies of the genital tract often have anomalies of the urinary tract. Developmental anomalies of the Müllerian system fall into three broad categories: agenesis, defects of lateral fusion, and defects of vertical fusion. Agenesis, or the Mayer-Rokitansky-Küster-Hauser syndrome, is congenital absence of the proximal vagina and cervix with variable development of the uterus. Lateral fusion defects reflect failed formation of a Müllerian duct, failed fusion of the two ducts, or failed absorption of the septum after fusion. Vertical fusion defects reflect failed fusion of the caudal Müllerian duct and urogenital sinus or abnormal canalization of the vagina following fusion. The incidence of Müllerian anomalies is estimated to be 3%, but the true incidence is unknown because many are asymptomatic and subclinical. Patients with agenesis often present during adolescence with primary amenorrhea, whereas those with fusion defects may present during adolescence with abnormal bleeding, pelvic pain, or a mass associated with uterine or vaginal obstruction. In other cases, menses may be normal and the diagnosis may be delayed until infertility or obstetrical complications prompt evaluation.

Evaluation Figure 24-5 Radiographic view of a 15- to 18-cm Wolffian duct cyst.

Anomalies of the reproductive outflow tract should be suspected in adolescents with amenorrhea, oligomenorrhea,

Disorders of the Female Pelvis 181



or abnormal bleeding; cyclical pelvic pain with no or irregular bleeding; and dysmenorrhea that increases quickly in severity. In patients with obstructive anomalies, the uterine cavity and vagina may be distended by thickened, stimulated endometrium. Without a mechanism for drainage, the retained endometrial tissue causes increasing pain. Pelvic examination, if tolerated by the adolescent, often provides evidence of an anomaly but rarely allows definitive diagnosis. Transabdominal and transvaginal ultrasonography helps define the anatomy further, but examination under anesthesia with hysterosalpingography and often laparoscopy is required in patients with complex anomalies. Consultation with a gynecologist who is familiar with congenital anomalies is essential for diagnosis, management, and patient counseling. Renal ultrasound should be performed in all patients with congenital anomalies of the uterus and upper vagina because of the high rate of coincident renal anomalies. It is particularly important to determine the urogenital anatomy before attempting surgical correction of an obstructed reproductive tract to minimize the risk of injury to a misplaced or duplicated ureter.

cord–stromal tissue. The most common benign ovarian neoplasms in adolescents are mature cystic teratomas and serous or mucinous cystadenomas (Figures 24–6 and 24–7). The most common malignant ovarian neoplasms in adolescents are germ cell tumors. However, less than 5% of ovarian malignancies occur in individuals under age 18 years, and only 1% of all malignancies in this age group are ovarian. The most common germ cell tumor is the mature cystic teratoma, or dermoid cyst. It is a benign, multicystic mass that may include tissue of ectodermal, mesodermal, and endodermal origin, including teeth, hair, and skin. Although benign, the complications of benign teratomas include torsion in up to 16% of cases and, much less commonly, spontaneous rupture. The transition between the normal ovarian tissue and the teratoma,

Management Nonobstructive anomalies of the Müllerian system, such as uterine agenesis, typically do not require surgical intervention. Depending on the anatomical structures involved and the severity, vaginal dilatation may be necessary to allow sexual intercourse. This can be performed at home by the patient when she is psychologically and emotionally ready. Obstructive anomalies, particularly when there is functioning endometrium, require surgical intervention to relieve pain and allow appropriate flow of menstrual fluid. Hymenal and vaginal anomalies may be addressed by a vaginal approach. Obstruction caused by a relatively thin structure, imperforate hymen, thin vaginal septum, or lower vaginal atresia may all be treated by resection of the obstructing barrier and anastomosis of the upper vaginal mucosa either to the lower vaginal mucosa or the distal hymenal ring. If a thicker vaginal obstruction is present, a graft of skin or bowel segment may be necessary to bridge the upper and lower vaginal mucosal. The patient with a complex surgical repair may need to use a dilator for a short interval postoperatively.

Figure 24-6 Intraoperative view of a left ovarian mass in a 15-year-old female.

Ovarian Tumors Epidemiology and Pathophysiology Ovarian tumors can be benign or malignant and can develop from germ cells, epithelial cells, or sex

Figure 24-7 Intraoperative views during ovarian cystectomy. The ovarian cortex is open to allow dissection and removal of the mucin-containing cystadenomas.

182 Adolescent Medicine: The Requisites in Pediatrics

termed Rokitansky’s protuberance, can contain immature elements and therefore require careful histological examination. Immature teratomas are malignant ovarian tumors that contain disorganized tissue from all three germ cell layers. They comprise less than 1% of teratomas and are most likely to present during the first two decades of life. The most common malignant germ cell tumor is the dysgerminoma. It consists of primordial, sexually undifferentiated cells and is associated with gonadal dysgenesis and androgen insensitivity. Serum lactic dehydrogenase (LDH) levels and, less often, serum HCG levels are often elevated in patients with dysgerminomas (Table 24-1). In adults, epithelial cell malignancies account for 6–11% of all adnexal masses and constitute the most common type of ovarian cancer. In adolescents, the most common epithelial cell tumors are benign serous or mucinous cystadenomas. They can reach large sizes and pose significant risk of torsion, as well as leakage into the peritoneal cavity. On histological examination, 7% of cystadenomas are borderline for malignancy and 4% are overtly malignant. Sex cord–stromal tumors are uncommon in adolescents. For example, gonadoblastoma is a rare tumor composed of both sex cord and germ cell tissue. Most cases are in patients with gonadal dysgenesis and a Y chromosome or Y fragment, and 25–50% are associated with malignant dysgerminoma. Granulosa cell tumors are another rare type of sex cord–stromal tumor in adolescents. The juvenile subtype has a better prognosis than the adult subtype, with survival rates of 84–92%. Juvenile granulosa cell tumors secrete estrogen and may present as abnormal menstrual bleeding. Bilateral ovarian involvement is found in 5% of cases.

Evaluation and Management Pelvic ultrasound should be performed early in the evaluation of an adolescent with an adnexal mass. It helps delineate characteristics that may change the differential diagnosis and management plan, such as size, location, content (e.g., fluid or solid), and associated findings (e.g., ascites). Some ovarian neoplasms secrete protein tumor markers that facilitate diagnosis and provide a measure of the clinical response to treatment. The markers include alpha-fetoproten (AFP), lactate dehydrogenase (LDH), CA-125, human chorionic gonadotropin (HCG), carcinoembryonic antigen (CEA), inhibin, and Müllerian-inhibiting substance. Surgery is directed at preservation of reproductive potential. Unless a malignancy is diagnosed at the time of the initial procedure, conservative surgery should be performed with excision of the lesion and ovarian reconstruction or a unilateral salpingo-oophorectomy. If malignancy is suspected or confirmed, adequate staging includes abdominal exploration, peritoneal washings, biopsies of suspicious areas, and periaortic and pelvic lymph node sampling. Minimally invasive surgery does have a role in the treatment of adolescents with pelvic masses but should only be performed if the surgeon is skilled at laparoscopy and if the procedure can be accomplished without spillage of malignant contents.

 l

Human chorionic gonadotropin (HCG) Lactate dehydrogenase (LDH) CA-125 Carcinoembryonic antigen (CEA) Alpha-fetoprotein (AFP)

Inhibin Müllerian-inhibiting substance Testosterone Estradiol

Dysgerminoma Mixed germ cell tumors Choriocarcinoma Dysgerminoma Mixed germ cell tumors Epithelial tumors Immature teratoma Mucinous tumors Serous tumors Mixed germ cell tumors Immature teratoma Endodermal sinus tumors Granulosa cell tumor Granulosa cell tumor Sertoli-Leydig cell tumor Leydig cell tumor Adult granulosa cell tumor

b

The differential diagnosis for acute-onset pelvic pain in an adolescent female includes pelvic inflammatory disease, rupture of an ovarian cyst, ectopic pregnancy, and adnexal torsion. l Adnexal torsion is a difficult diagnosis that requires a high index of suspicion and prompt surgical intervention. The treatment of choice is detorsion with preservation of ovarian tissue. l First-line therapy for endometriosis is combined estrogen-progestin (e.g., OCPs) and NSAIDs. If pain persists, laparoscopy is indicated to confirm the diagnosis and to remove or ablate visible endometrial implants. l Small, functional ovarian cysts may be managed conservatively without surgery if pain is controlled. l Congenital anomalies of the female reproductive tract include Wolffian duct remnants, Müllerian duct agenesis, and fusion defects of the Müllerian system or urogenital sinus. l Ovarian malignancies are rare during adolescence and are more likely to be of germ cell than epithelial cell origin. l

Table 24-1 Serum Tumor Markers

Major Points



Bibliography American Society for Reproductive Medicine: Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril 1997;67:817–821. Ballweg ML: Big picture of endometriosis helps provide guidance on approach to teens. J Pediatr Adolesc Gynecol 2003;16(3 Suppl):S21–S26. Celik A, Ergun O, Aldemir H, et al.: Long-term results of conservative management of adnexal torsion in children. J Pediatr Surg 2005;40:704–708. Halban J: Hysteroadenosis metastica. Wien Klin Wochenschr 1924;37:1205. Laufer MR, Sanfilippo J, Rose G: Adolescent endometriosis: Diagnosis and treatment approaches. J Pediatr Adolesc Gynecol 2003;16(3 Suppl):S3–S11.

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Mayer CAJ: Ober Verdoppelungen des Uterus and ihre Arten, nebst Bemerkungen uber Hasenscharte ind Wolfsrachen. J Chir Auger 1829;13:525. Morowitz M, Huff D, von Allmen D: Epithelial ovarian tumors in children: A retrospective analysis. J Pediatr Surg 2003;38: 331–335; discussion 331–335 Sampson J: Peritoneal endometriosis due to menstrual disemination of endometrial tissue in the peritoneal cavity. Am J Obstet Gynecol 1925;14:422. You W, Dainty LA, Rose GS, et al.: Gynecologic malignancies in women aged less than 25 years. Obstet Gynecol 2005;105:1405– 1409.

25

C h A p t e r

Introduction Definitions Vaginitis Candidiasis Trichomoniasis Bacterial Vaginosis

Urinary Tract Infection Evaluation Management

Vulvar Abnormalities Developmental Variants Vulvar Itching and Irritation Vulvar Lesions

Introduction Vaginal and urinary symptoms are common complaints that produce significant physical and emotional discomfort for many adolescents. Patient embarrassment about the symptoms and clinician uncertainty about the evaluation can delay accurate diagnosis and treatment. Young adolescents may have difficulty describing the symptoms or may assume that the details on history are unnecessary for diagnosis. Others may worry that the symptoms imply or reveal sexual activity. For adolescents in whom the symptoms do reflect sexually transmitted infections, the delay or failure to treat imposes risk for both the patient and her sexual partners. The goal of this chapter is to familiarize the reader with an evidence-based approach to the evaluation and management of urinary and vulvovaginal symptoms in adolescents. It is important to recognize that the chief complaint does not localize the pathology. In other words, urinary symptoms may reflect genital pathology and vice versa.

184

Vaginitis, Urinary  Tract Infection, and Vulvar Lesions Jill S. Huppert, MD, MPH Linda M. Kollar, RN, MSN

Definitions Bacterial vaginosis: Vaginal discharge characterized by bacteria-coated epithelial cells and few white blood cells on wet mount. Leukorrhea: Vaginal discharge with abundant epithelial cells. Pyelonephritis: UTI (see below) with involvement of the upper tract. Pyuria: > 10 leukocytes per microliter on an unspun midstream urine collection or > 10 leukocytes per high-powered field on a spun sample. Urethritis: Inflammation of the urethra. Urinary tract infection (UTI): Urinary symptoms, pyuria, and culture of a midstream, clean-catch urine specimen demonstrating > 102/ml to > 105/ml colonyforming units (CFU)/ml of a uropathogen. Studies and clinical guidelines vary in their choice of cut-point for a positive culture. Urine leukocyte esterase: Screening test that detects pyuria with a sensitivity of 75–96% and specificity of 94–98%. Urine nitrite: Screening that detects 105 CFU/ml with fair sensitivity and specificity. Uropathogens: Bacteria that cause UTI, such as Escherichia coli, Staphylococcus saprophyticus, Proteus mirabilis, Klebseilla species, and enterococci. Vaginitis: Vaginal inflammation, usually with vaginal discharge, itching, and irritation. Vulva: External female genitalia, including the mons pubis, labia majora, labia minora, clitoris, vestibule of the vagina, bulb of the vestibule, and Bartholin’s glands. Wet mount: The microscopic evaluation of vaginal secretions collected by swab and suspended in 0.5–1 ml normal saline.

Vaginitis, Urinary Tract Infection, and Vulvar Lesions 185



Vaginitis Vaginal secretions provide lubrication as well as local immune factors to protect against infection. The predominant endogenous bacteria, lactobacilli, produce ­lactic acid and hydrogen peroxide that maintains the low pH (2.5–4.5) of the vaginal canal. The usual flora also includes Gardnerella vaginalis; beta-hemolytic Streptococci; Mycoplasma hominis, Ureaplasma urealyticum; and Candida species. Less common colonizers include Proteus, Klebsiella, and other enterococci. The vaginal flora is affected by endogenous and exogenous hormones, race, sexual behavior, contraceptive method, and douching. The proportion of anaerobic bacteria increases premenstrually. Baseline pH and the prevalence of bacterial vaginosis (BV), M. hominis, and group B streptococcus are higher in African-American than Caucasian or Mexican-American women. New and multiple sexual partners are associated with BV, and oral sex is associated with both BV and Candida. Consistent condom use, oral contraceptives, and frequent douching are associated with BV. Although most studies attempt to control for confounding variables, more research is needed to elucidate independent risk factors for BV. Many adolescents have a normal, physiological vaginal discharge that is white, odorless, of small to moderate ­volume, and characterized by abundant epithelial cells (i.e., leukorrhea). The discharge may begin during the year prior to menarche and may continue throughout reproductive life. Physiological leukorrhea is a normal finding requiring only reassurance. In contrast, vulvovaginal itching, burning, pain, or redness are abnormal and ­warrant evaluation. Vaginal discharge accompanied by symptoms is usually caused by candidiasis, BV, or trichomoniasis (Box 251). Other causes include Neisseria gonorrhea (NG), Chlamydia trachomatis (CT), retained foreign body (e.g., tampon), desquamative vaginitis secondary to overgrowth of aerobic bacteria, fistulae associated with inflammatory bowel disease or pelvic surgery, and vulvar contact dermatitis. Box 25 - 1  Causes of Vaginal Discharge l l l l l l l l

Candidiasis Trichomoniasis Bacterial vaginosis Neisseria gonorrhea Chlamydia trachomatis Foreign body Desquamative (aerobic) vaginitis Fistula

Candidiasis Epidemiology:  Vulvovaginal candidiasis is highly prevalent during adolescence and adulthood, with 50% of adult women reporting at least one lifetime episode and 25% reporting an episode before age 25 years. The prevalence of colonization in asymptomatic females is < 5% before menarche and 20% by late adolescence. Candida is detected by culture in 29–75% of women with vaginal discharge, and 5–58% with positive cultures for Candida report symptoms. The most common species is Candida albicans, identified in 80–90% of cultures, with C. glabrata occurring in 10–20%. Other Candida species have been reported in increasing numbers in the last few years, perhaps due to improved detection or to the use of therapies that preferentially eradicate C. albicans. Pathophysiology: Candida species are considered to be part of the normal flora of the vagina. The change from asymptomatic colonization to vulvovaginal candidiasis reflects the loss of local immunity with a resulting increase in the quantity of Candida and a host inflammatory response. Factors that may precipitate a shift from colonization to infection include estrogen status, the presence of glycogen, and the loss of protective bacterial flora. Candida prefers a nutrient-rich environment, and growth is enhanced by factors that increase the glycogen content of epithelial cells. Impaired glucose tolerance and high estrogen states, such as those created by pregnancy and the use of oral contraceptives, are known risk factors for candidiasis. Antibiotic use also is a risk factor for candidiasis, presumably due to the alteration of normal vaginal protective factors. Receptive oral sex appears to be the only sexual behavior that increases the risk of candidiasis. Evaluation: The symptoms most consistently associated with candidiasis are vulvovaginal itching or burning, followed by erythema. The classic curdy, white discharge is seen in about 50% of women with candidiasis, and discharge alone is not strongly predictive of candidiasis. The gold standard for diagnosis is culture on selective media (Table 25-1), but the diagnosis is usually made clinically by microscopic examination of the wet prep with a drop of potassium hydroxide (KOH) added to the slide. Visualization of pseudohyphae and budding yeast forms is 22–50% sensitive for candidiasis (Figure 25-1). Unampli­ fied RNA testing (Affirm VPIII, Becton Dickinson, Sparks, MD) is slightly more sensitive than wet mount and does not require microscopy but is more costly and complex to perform. Management: Candidiasis is considered a self-limited disease for which symptomatic treatment is sufficient. However, recent evidence suggests that the inflammatory changes associated with candidiasis may increase a woman’s susceptibility to infections such as human immunodeficiency virus (HIV).

186 Adolescent Medicine: The Requisites in Pediatrics

Table 25-1  Diagnostic Test Characteristics for Candidiasis, Trichomoniasis, and Bacterial Vaginosis Test

Sensitivity (%)

Specificity (%)

Candidiasis

Wet mount RNA Culture

22–50 ?

100 ?

Trichomoniasis

In-pouch Tv culture Wet mount Rapid antigen (OSOM) RNA (Affirm VPIII) Conventional Pap smear Liquid-based Pap smear PCR1

85 36–70 90 90 36–55 61–96 84–98

100 99–100 100 99 90 99 94–99

Bacterial Vaginosis

Amsel criteria Nugent gram stain RNA (Affirm VPIII) Sialidase (BVBlue) pH and amines (FemExam) PCR1

77 89 ? 88 71 84–98

58 90 ? 95 72 94–99

Gold Standard

PCR, polymerase chain reaction.

1

Figure 25-1 Example of wet mounts showing normal squamous cells (Sq), clue cells (Clue), Candida (Ca), and trichomonads (Tv).

About 5–10% of women suffer from recurrent vulvovaginal candidiasis, defined as four or more symptomatic episodes per year. These women may benefit from culture documentation of both infection and cure to identify the responsible Candida species and to distinguish between relapse and reinfection. Although most have no identifiable risk factors, they may warrant an evaluation for precipitating factors such as diabetes or immune compromise. The goal of treatment is to alleviate symptoms and reduce the burden of Candida colonies. Topical antifungal agents, such as miconozole and clotrimazole, are safe and effective. A short, 1–3 day course produces a clinical cure and negative culture in 80–90% of patients. Even if the predominant symptoms are vulvar, intravaginal treatment is necessary to address the source of the Candida. All of the currently available preparations are equally effective; thus the choice will be guided by cost and availability. Oral fluconazole is effective at producing a cure and may be more acceptable to adolescents who have no experience using intravaginal items such as tampons. However, symptoms may persist longer following oral than intravaginal therapy.

Regardless of therapy, patients should be counseled that symptoms usually diminish in 24–72 hours and resolve within 6–8 days. Alternative therapies without proven efficacy for prevention or cure include cotton underwear, loose-fitting clothing, topical or oral lactobacillus, and yogurt. Women with recurrent candidiasis may benefit from longer courses (7–14 days) of topical antifungal medications or repeated doses of oral fluconazole to cure each episode. They may also require weekly or monthly doses for suppressive therapy. Flucytosine and boric acid vaginal capsules have both been used successfully in some recalcitrant cases.

Trichomoniasis Epidemiology: Trichomoniasis is caused by a parasitic protozoa, Trichomonas vaginalis (Tv). Prevalence in adolescents ranges from 5–17%. In the only population-based study to date, the prevalence of Tv is higher than NG, similar to CT, higher in African-American than Caucasian women, and higher in the southeast than other regions of the

Vaginitis, Urinary Tract Infection, and Vulvar Lesions 187



United States. Tv is present in 12–30% of women with vaginal symptoms and is associated with sexual risk behaviors such as multiple partners and lack of condom use. Unlike CT and NG, young age is not an important risk factor for Tv. Although the majority of sexually transmitted infections (STIs) occur in asymptomatic women, T   v and NG are more strongly associated with genitourinary symptoms than CT. Thus, if the reason for STI testing is genitourinary symptoms, a careful assessment for T   v and NG is warranted. Pathophysiology: Tv has four anterior flagella and an undulating membrane that provide propulsion and give the organism a jerky appearance on the wet mount. The free-swimming oval parasite takes on an amoeboid form when it attaches to the vaginal epithelial cells. Adherence is required to maintain infection and is promoted by the presence of iron and higher pH (which makes menses a favorable environment). Adhesion is disrupted by imidazole drugs such as metronidazole. After adhering, Tv releases proteases and glycoproteins that cause epithelial disruption. It induces an intense inflammatory response involving cytokines, IgG and IgA antibodies, neutrophil defensins, reduction of lactobacilli, and an increase in pH. Clinically, the host response to infection corresponds to the findings of discharge, bleeding, and worsening of symptoms at menses. These mechanisms also explain the increased susceptibility of those infected with Tv to other pathogens, most notably HIV and human papillomavirus (HPV). Finally, unlike CT and NG, Tv does not require endocervical cells for survival and therefore can produce a symptomatic infection in women without a cervix. Untreated, Tv has been estimated to persist for up to 5 years in women and is highly transmissible between partners. Fomite transmission has been speculated but never proven conclusively. Evaluation:  The classic description of  Tv infection is a characteristic frothy green discharge and punctate hemorrhage of the cervix (strawberry cervix). However, approximately 50% of women with  Tv are asymptomatic, and the classic strawberry cervix is seen in less than 2% of infected subjects. In the population study, 98% of those with  Tv denied symptoms in the last 30 days. The most common method of diagnosis is wet-mount identification of motile trichomonads (Figure 25-1). Diagnosis can also be made using cytological characteristics on the Papanicolau smear. Both the wet mount and Pap smear are less sensitive than culture, although specificity is high. Liquid-based cytology, such as ThinPrep (Cytec Corp, Boxborough, MA), seems to have improved sensitivity. Culture is the diagnostic gold standard, but it is not widely available and requires up to 4 days in a microbiology laboratory for final reading. A comparison of the diagnostic methods is shown in Table 25-1. Management: Historically, Tv has been viewed as a nuisance infection associated with sexual risk behaviors.

Recent studies, however, have linked Tv infection to pelvic inflammatory disease (PID), the acquisition of HIV, and shedding of HIV. Tv can be treated with an oral regimen of either metronidazole or tinidazole. Single-dose therapy is associated with better compliance and fewer side effects than multiday therapy, and tinidazole has fewer gastrointestinal side effects than metronidazole. Topical preparations may reduce symptoms but do not eradicate the infection. Partner treatment is recommended, and the patient should be advised to abstain from intercourse until both the patient and partner have completed therapy. As for all STIs, condom use should be encouraged to prevent ­reinfection. Studies suggest that 5–9% of Tv isolates demonstrate some resistance to metronidazole. Clinically, treatment failure due to nonadherence or reinfection from an untreated partner are more common than resistance. Patients with suspected resistance can be treated with longer courses of metronidazole or a trial of tinidazole.

Bacterial Vaginosis Epidemiology: BV refers to a nonspecific vaginitis first described by Gardner in 1955. BV was attributed to Haemophilus vaginalis (renamed Gardnerella vaginalis) until the 1980s, when the single-bacterium theory was discarded and the syndrome was redefined according to its four clinical characteristics, now termed  Amsel Criteria (Box 25-2). Nugent Criteria for gram stain diagnosis of BV (Table 25-2) are used less commonly than Amsel Criteria. The term “bacterial vaginosis” reflects the bacteria-coated epithelial cells (i.e., clue cells) on wet mount that provide a clue to the diagnosis, coupled with the relative lack of white blood cells on wet mount ­ compared with the causes of vaginitis discussed previously (Box 25-1). The prevalence of BV is 12–18% in asymptomatic adolescent females who have not had sexual intercourse and 28–32% in those who have had intercourse. The rates are similar in adolescent and adult females and are higher in African-American than Caucasian females. Risk factors for BV include sexual intercourse, oral sex, smoking, and ­douching. Pathophysiology: The pathophysiology of BV is complex and still incompletely understood. It is best

Box 25-2 Amsel Criteria for the

Diagnosis of Bacterial Vaginosis (3 of 4 Required)

l l l l

Homogeneous thin, gray vaginal discharge pH > 4.5 > 20% clue cells on wet mount “Whiff”: fishy odor after application of potassium hydroxide (KOH)

188 Adolescent Medicine: The Requisites in Pediatrics

Table 25-2 Nugent Gram Stain Criteria for Bacterial Vaginosis1

Score 0 1 2 3 4

Lactobacilli

Gardnerella/ Bacteroides

Curved Gram Variable Rods

4+ 3+ 2+ 1+ 0

0 1+ 2+ 3+ 4+

0 1+ or 2+ 3+ or 4+

1 Score determined by the quantity seen in an oil immersion field. Total score: 0–3, negative; 4–6, intermediate; 7–10, bacterial vaginosis (BV).

described as a shift in the normal vaginal flora characterized by a decrease in lactobacillus species and an increase in anaerobic bacteria such as Gardnerella vaginalis and Bacteroides spp. These changes result in an elevated pH, the production of malodorous amines, and a possible increase in local cytokines. No single causative agent has been identified, and recent attention has turned to the molecular identification of species that cannot be cultivated in the laboratory. Evaluation: At least three large studies in adult females and one study in adolescents found little correlation between a diagnosis of BV and vaginal symptoms. Factors that have been associated with BV include race, sexual behavior, douching, and smoking. Table 25-1 compares various diagnostic methods for BV. Amsel Criteria are subjective, depend upon clinician experience, and require microscopy. Some have advocated using the combination of pH > 4.5 plus either clue cells or an amine odor to increase specificity without significant loss of sensitivity. Nugent Criteria are based on a gram stain of vaginal fluid and are considered the gold standard for diagnosis (Table 25-2). However, they are time-intensive and rarely used in clinical settings. Several objective, point-of-care tests have been developed, but the associations between these test results and clinical outcome remain unclear. Management: Associations have been reported between BV and adverse outcomes, including premature birth, PID, and postoperative infections. There is good evidence that women with BV who are treated with metronidazole have fewer postoperative and postabortion infections. However, recent data using Nugent Criteria report no increased risk of PID in women with BV and no improvement in perinatal outcome with treatment of BV. The Centers for Disease Control and Prevention (CDC) recommend treatment only for symptomatic BV and for asymptomatic women undergoing abortion or hysterectomy. Clinical relapses and treatment failures are common, making it important to limit diagnosis to those who are symptomatic and in whom other pathogens have been excluded. The goal of treatment is alleviation of

symptoms, not cure, because BV represents a shift in normal flora. Accepted treatment regimens include intravaginal metronidazole or clindamycin and oral metronidazole. Intravaginal metronidazole appears to be the therapy that is least disruptive to other normal vaginal flora. Partner therapy is not recommended.

Urinary Tract infection Urinary symptoms such as dysuria, urinary urgency, and urinary frequency are common reasons for health care visits among adolescent and young adult females. Although the symptoms often reflect an underlying urinary tract infection (UTI), it is important to recognize that STIs and vulvar lesions can present with urinary rather than vaginal symptoms (Box 25-3). Epidemiology: Bacteriuria on urine culture is found in 5% of asymptomatic, nonpregnant adolescent females and in 24–57% of those with urinary symptoms. The former are defined as having asymptomatic bacteriuria, and the latter are defined as having UTI. In adult females, UTI is associated with sexual intercourse, new sexual ­partners, and the use of barrier contraceptives (e.g., ­diaphragm). Pathophysiology: The most common urinary pathogens are bacteria that reside normally in the gastrointestinal tract. Escherichia coli is responsible for 60–90% of UTIs, enterococci for 10–30%, and S. saprophyticus for 5–10%. The transition from asymptomatic bacteriuria to UTI is mediated by local inflammation and is characterized by pyuria.

Evaluation A positive urine culture is the gold standard for the diagnosis of UTI in a symptomatic patient with pyuria (i.e., >10 leukocytes per high-powered field). The definition of a positive urine culture varies across studies and clinical guidelines, from > 102 CFU/ml to > 105 CFU/ml. The presence of leukocyte esterase on dipstick testing of the urine indicates pyuria with a sensitivity of 75–96% and specificity of 94–98%. The presence of nitrite on dipstick testing indicates bacteriuria with a

Box 25-3 Conditions Associated with

Urinary Symptoms

l l

l l l

Urinary tract infection: bacterial pathogen Sexually transmitted pathogen causing urethritis: Tv, NG, CT Vulvitis: candida, HSV Vulvar lesions Anatomical lesions: urethral diverticula, prolapse

Vaginitis, Urinary Tract Infection, and Vulvar Lesions 189



fair sensitivity at high colony counts (i.e., 105 CFU/ml) but is relatively insensitive at lower colony counts. Although history, pyuria, and dipstick testing are reasonably accurate for the diagnosis of UTI in adult populations, the accuracy diminishes when the prevalence of STIs increases, as in adolescent populations. Women who experience one UTI are at increased risk for a second UTI and are at 4- to 12-fold risk for pyelonephritis (see Definitions, as discussed previously). The clinical manifestations of pyelonephritis include evidence of upper urinary tract involvement (e.g., fever, flank pain, and costovertebral angle tenderness), pyuria, and positive urine culture. Complications of pyelonephritis include sepsis, renal abscess, perinephric abscess, renal scarring, hypertension, and decreased renal function. Reflux nephropathy and recurrent pyelonephritis during early childhood may result in chronic scarring with the development of hypertension years later, during adolescence. STIs must be considered in the evaluation of sexually active females with urinary symptoms. Tv and NG are more commonly associated with urinary symptoms than CT in both adolescent and adult women, although CT has been shown to cause sterile pyuria. Infections that cause vulvar lesions, such as herpes simplex virus (HSV), often are associated with dysuria (Chapter 28). Other causes of urinary symptoms include urethral prolapse, urethral diverticulum, and nephrolithiasis. Urethral prolapse is associated with hypoestrogenization and is more common before than after menarche. Urethral diverticulum is more likely to cause urinary frequency and dribbling than dysuria. Stones can cause back, flank, abdominal, or pelvic pain; dysuria, urinary frequency; and hematuria.

Management Asymptomatic bacteriuria progresses to clinical UTI within 1 week in 8–15% of females. In most females, however, asymptomatic bacteriuria is transient and requires no treatment. Pregnancy represents an important exception because of the association between asymptomatic bacteriuria and preterm delivery. Pregnant women therefore are screened and treated for ­asymptomatic bacteriuria. Acute cystitis should be treated with a 3-day course of an oral antibiotic such as of trimetho­prim, trimethoprim/ sulfamethoxazole (TMP/SMX), or ciprofloxacin; or a 7-day course of nitrofurantoin. For patients who cannot tolerate these antibiotics, a 5-day course of amoxicillinclavulanate can be prescribed. Single-dose treatment appears to be less effective than multiday regimens. Although the fluoroquinolones demonstrated the highest efficacy with the shortest treatment duration, their use for uncomplicated cystitis is discouraged because of the emergence of fluoroquinolone-resistant uropathogens.

Nitrofurantoin is well tolerated and effective against most uropathogens when continued for a full 7-day course, but it is ineffective against many Proteus, Enterobacter, and Klebsiella species. There is no evidence that increased hydration or cranberry juice are helpful in the treatment of acute cystitis, although there is evidence that cranberry juice may help prevent recurrent infections. Symptoms of acute infection usually resolve within 72 hours of antibiotic therapy. Phenazopyridine, a urinary analgesic, can be prescribed at a dose of 200 mg orally every 8 hours to control severe dysuria during the first 1–2 days of ­treatment.

Vulvar Abnormalities Developmental Variants Concerns about the appearance of the external genitalia are common among adolescent females. In many cases, the ­concern reflects unfamiliarity with the normal developmental changes that occur during puberty (Figure 25-2). In addition to the growth of pubic hair,the labia minora ­elongate and become rugated and pigmented. Asymmetry or unilateral hypoplasia of the labia minora (Figure 25-3) rarely causes physical discomfort and generally requires no treatment other that reassurance that it is a variant of normal. Variants of hymenal anatomy often are unrecognized until puberty, tampon use, or the initiation of sexual intercourse. The hymen remains imperforate until late in embryonic development, when normal canalization produces either a fimbriated or smooth opening (Figure 254). Imperforate hymen occurs in < 0.1% of females, but partial canalization with a resulting septate or cribiform hymen occurs in approximately 1% of females. Both of these conditions require surgical correction.

Vulvar Itching and Irritation Vulvar itching and/or irritation (Table 25-3) can be caused by infectious agents or dermatoses. Infectious causes include candidiasis or trichomoniasis (see previous sections), genital herpes (Chapter 28), and genital warts (Chapter 27). Candida vulvitis produces significant erythema, edema hyperkeratosis or lichenification, and linear fissures or excoriations at the forchette (Figure 25-5). Psoriasis and eczema are common, noninfectious causes of chronic or recurrent vulvar itching. Lichen sclerosis is a noninfectious dermatosis affecting 1:1000 females and is less ­ common in adolescents than in prepubertal and postmenopausal females. Lichen planus is an inflammatory condition of the skin, nails, and mucosal that typically appears as shiny, violaceous papules with white lines (i.e., Wickham striae). Vulvar involvement occurs in half of females with lichen planus, but it is much more common in adults than children or adolescents.

190 Adolescent Medicine: The Requisites in Pediatrics

Clitoris

Labia majora

Labia minora

Urethra

Figure 25-2 Normal vulvar anatomy in an adolescent with

Skene’s gland and duct

Tanner Stage 4 pubic hair and attenuated labia minora. Skene’s and Bartholin’s glands are not normally detectable; their anatomical locations are indicated with dotted lines for reference.

Vagina

Bartholin’s gland and duct

Hymen Forchette

Figure 25-3 Normal labial asymmetry. Left labia minora is smaller and less rugated than the right.

Vulvar contact dermatitis can be caused by soaps, bubble bath, shampoo, perfume, feminine hygiene products, barrier contraceptive products, topical medications, latex, dyes, and semen. Approximately 20% of cases are allergic responses to an environmental trigger, whereas 80% are skin or mucosal damage caused directly by the trigger. Folliculitis (i.e., infection of the hair follicle) and pseudo-folliculits barbae can occur in any hair-bearing area, particularly if shaved. Folliculitis usually responds to warm compresses but may require incision and drainage or antibiotics. Shaving should be discontinued for at least 30 days in pseudo-folliculitis barbae and preferably discontinued. Some patients have improved with topical antibiotics, retinoids, and laser therapy. Hidradenitis suppurotiva is a chronic inflammatory skin condition affecting 1–4% of the population. Hair follicles and apocrine glands in androgen-sensitive skin manifest chronic obstruction and inflammation but, unlike acne vulgaris, there is no increase in sebum production (Figure 25-6).  It is more common in postpubertal females and can occur in the axillae as well as the groin and vulva.

Figure 25-4 Normal hymen anatomy and variants. The fimbriated hymen has ruffled folded edges that may obscure the opening. The circum­ ferential hymen is smooth and can form a complete or partial circle. The septate hymen has a longitudinal band of varying thickness. The examiner can use a cotton-tipped applicator moistened with anesthetic gel or can apply gentle downward traction on the labia majora to improve visualization.

A Normal smooth hymen

B Normal fimbriated hymen

C Septate hymen

Vaginitis, Urinary Tract Infection, and Vulvar Lesions 191



Table 25-3 Causes of Vulvar Symptoms Predominant Symptom

Etiological Category

Itching and pain

Infectious

Noninfectious

Raised or palpable lesions

Infectious Noninfectious

Pigmented lesions

Noninfectious

Etiology Vaginitis HSV HPV Folliculitis/furuncles (boils) Bartholin’s abscess Clitoral abscess Contact dermatitis Psoriasis Eczema Lichen sclerosis Lichen planus Fox-Fordyce disease Hidradenitis suppurativa Aphthous ulcers Behçet’s disease Crohn’s disease HPV Molluscum contagiosum Acrochordon (skin tags) Sebaceous glands Epidermal inclusion cysts Fox-Fordyce disease Hidradenitis suppurative Lipoma Syringoma Vaginal masses Melanosis Acanthosis nigricans Nevus Sebhorreic keratosis Melanoma Vascular malformation

HSV,  herpes  simplex  virus;  HPV,  human  papillomavirus.

Figure 25-6 Pustular lesions, scarring, and hyperpigmentation in a female with hidradentitis suppurativa.

Patients present with erythema, itching, pain, and cystic nodules that initially are difficult to distinguish from folliculitis. The cysts may progress to boils that may rupture and lead to scarring, hyperpigmentation, or draining sinus tracts. Acute therapy includes warm compresses, incision and drainage, and oral antibiotics. Preventive therapy with demonstrated efficacy includes isotretinoin, topical and oral antibiotics, and oral contraceptive pills. Extensive disease may require surgery, and some believe that surgical resection is the treatment of choice. Fox-Fordyce disease is a rare condition that results from the obstruction of apocrine glands without inflammation. It is most common in African-American adult women and presents as small, intensely pruritic, flesh-colored papules in the axillae and groin. Treatment suggestions are based on case reports and include topical antipruritic medications, topical antibiotics, oral contraceptive pills, and isotretinoin.

Vulvar Lesions

Figure 25-5 Lichenification of vulvar skin seen with chronic candidiasis.

Vulvar masses and lesions may represent STIs, aphthous ulcers, or local manifestations of systemic diseases such as Crohn’s disease or Behçet’s disease. Aphthous ulcers of the vulva are usually large and shallow with a raised ­border and overlying exudate (Figure 25-7). Although ­several infectious etiologies have been proposed (e.g., Epstein-Barr virus, cytomegalovirus, and paratyphoid fever), the largest series in adolescents failed to identify infectious etiologies. Empirical treatments include topical anesthetics or steroids. “Complex aphthosis” is the term used to describe patients without Behçet’s disease who have recurrent, severe oral and genital ulcerations without other syste­ mic manifestations. Behçet’s disease has an unknown etiology and is rare in the United States and in children. The criteria for diagnosis of Behçet’s disease include recur-

192 Adolescent Medicine: The Requisites in Pediatrics

Figure 25-7 Large, shallow aphthous ulcer with raised pink edges and an overlying thin exudate on the ulcer. Other material seen in the labial folds represents residual from prior topical agents and inadequate hygiene.

rent oral ulceration plus at least two of the following: recurrent genital ulceration, uveitis, or skin lesions such as erythema nodosum. Ulcers are deep, painful, and heal with scarring. Patients may also develop arthritis, gastrointestinal lesions, vasculitis, and central nervous system involvement. The vulvar manifestations of Crohn’s disease are characterized as “knife-cut” ulcers, usually located in the inguinal and interlabial folds. The ulcers may predate gastrointestinal symptoms and may be difficult to distinguish from hidradenitis suppurativa (Figure 25-8). Acrochordons are more commonly called skin tags; they range in size from a few millimeters to more than 2 cm and can occur in any area of the body. Prevalence is unknown, but there appears to be a familial tendency. Molluscum

c­ ontagiosum is caused by a poxvirus and transmitted through direct skin-to-skin contact, autoinoculation, or sexual contact. It is common in young children and adolescents. One seroprevalence study estimated that 23% of the adolescent population has been exposed. The infection presents as small, dome-shaped papules with central umbilication. Infection is usually self-limited except in immunocompromised patients. Diagnosis of these three entities is made clinically and confirmed with biopsy. The goal of treatment is to restore normal anatomy. Treatment options include excision, laser, and chemo-ablation. Both genital warts and molluscum respond to topical imiquimod. Obstructed sebaceous glands and epidermal inclusion cysts present as small, firm, yellow, subcutaneous nodules that often appear following vaginal delivery. Syringoma is a rare, benign skin tumor that presents as a flesh-colored nodule on the labia minora or the eyelids, often associated with itching. Finally, a vaginal mass at the introitus can be mistaken as a vulvar lesion. Examples include urethral diverticula, endocervical polyps, and Gartner’s duct remnants. The most common pigmented lesions of the vulva in adolescents are vitilgo, melanosis (freckles), and acanthosis nigricans (Chapter 24). Although vulvar melanoma is rare in adolescents, there are case reports in adolescents with lichen sclerosis.

 l

l

l

l

l

l

l

Figure 25-8 Fistula track with smooth edges on the vulva in a patient with Crohn’s disease. Patient was referred for possible Bartholin’s abscess. Multiple perianal fistulas were also present.

Major Points

b

Physiological leukorrhea is a white, odorless, nonpruritic, nonpainful discharge that typically begins shortly before menarche and may continue throughout reproductive life. Vaginal discharge accompanied by itching, pain, or odor is usually caused by candidiasis, bacterial vaginosis (BV), or trichomoniasis (Table 25-1). Other causes include NG, CT, foreign body, desquamation, fistulae, and contact dermatitis. Vaginal candidiasis responds to a 1–3 day course of a topical antifungal agent, such as miconozole and clotrimazole, in 80–90% of patients. Trichomoniasis can be treated with oral metronidazole or tinidazole in single-dose or multiday therapy. Topical preparations may reduce symptoms but do not eradicate the infection. BV in nonpregnant females should be treated if symptomatic with intravaginal metronidazole or clindamycin or oral metronidazole. Asymptomatic bacteriuria in nonpregnant females is usually transient and does not require treatment. Uncomplicated acute UTI should be treated with trimethoprim, trimethoprim/sulfamethoxazole (TMP/SMX), or nitrofurantoin. STIs should always be considered as a possible cause of urinary symptoms in sexually active adolescents.



Bibliography Barousse MM, Van Der Pol BJ, Fortenberry D, et al.: Vaginal yeast colonisation, prevalence of vaginitis, and associated local immunity in adolescents. Sex Transm Infect 2004;80:48–53. Gutman RE, Peipert JF, Weitzen S, et al.: Evaluation of clinical methods for diagnosing bacterial vaginosis. Obstet Gynecol 2005;105:551–556. Hooton T, Scholes D, Hughes J, et al.: A prospective study of risk factors for symptomatic urinary tract infection in young women. N Engl J Med 1996;335:468–474. Hooton T, Stamm W: Diagnosis and treatment of uncomplicated urinary tract infection. Infect Dis Clin North Am 1997;11: 551–581. Huppert JS, Biro F, Lan, D, et al.:  Urinary symptoms in adolescent females: STI or UTI? J Adolesc Health 2007;40:418–424.

Vaginitis, Urinary Tract Infection, and Vulvar Lesions 193

Huppert JS, Mortensen JE, Reed JL, et al.: Rapid antigen testing compares favorably with transcription-mediated amplification assay for the detection of Trichomonas vaginalis in young women. Clin Infect Dis 2007; 45: 194–198, Landers DV, Wiesenfeld HC, Heine RP, et al.: Predictive value of the clinical diagnosis of lower genital tract infection in women. Am J Obstet Gynecol 2004;190:1004–1010. Ronald A: The etiology of urinary tract infection: Traditional and emerging pathogens. Am J Med 2002;113(Suppl 1A):14S–19S. Ryan CA, Courtois BN, Hawes SE, et al: Risk assessment, symptoms, and signs as predictors of vulvovaginal and cervical infections in an urban US STD clinic: Implications for use of STD algorithms. Sex Transm Infect 1998;74(Suppl 1):S59–S76. Smith K, Harrington K, Wingood G, et al.: Self-obtained vaginal swabs for diagnosis of treatable sexually transmitted diseases in adolescent girls. Arch Pediatr Adolesc Med 2001;155:676–679.

26

C h Ap t e r

Introduction Definitions Gonorrhea Epidemiology Pathophysiology Evaluation Management

Gonorrhea, Chlamydia, and Pelvic Inflammatory Disease Tanya Kowalczyk Mullins, MD Paula K. Braverman, MD

these two organisms. The clinical presentations, evaluation, and management of adolescents with gonorrhea, chlamydia, and PID are discussed, with an emphasis on early recognition, treatment, and secondary prevention.

Definitions

Chlamydia Epidemiology Pathophysiology Evaluation Management

Pelvic Inflammatory Disease Epidemiology Pathophysiology Evaluation Management

Introduction Adolescents and young adults aged 15–24 years account for half of the 19 million sexually transmitted infections (STIs) that occur yearly in the United States. Factors contributing to the high STI rate among U.S. youth include developmental characteristics such as cervical ectopy, sexual risk behaviors, and inadequate screening of asymptomatic patients. Factors that appear to protect adolescents from STIs include parental involvement, perceived parental disapproval of adolescent sexual activity, and academic achievement. In addition to the risk of STI acquisition, delayed diagnosis and treatment of Neisseria gonorrhoeae and Chlamydia trachomatis in adolescents results in high rates of pelvic inflammatory disease (PID) and late sequelae such as infertility. This chapter reviews the epidemiology and pathogenesis of disease associated with 194

Cervical ectopy or ectropion: Junction of the squamous and columnar epithelium that normally recedes proximally with maturation, from the ectocervix to the endocervical canal. Cervicitis: Cervical inflammation due to infection, with resulting cervical erythema, friability, and/or discharge. Endometritis: Inflammation of the lining of the uterus, usually due to an STI. Fitz-Hugh-Curtis syndrome: Perihepatic inflammation (i.e., perihepatitis) that may occur as a complication of PID. Pelvic inflammatory disease (PID): Polymicrobial infection of the upper female genital tract generally due to ascent of organisms from cervical infection with gonorrhea or chlamydia. Salpingitis: Inflammation of the fallopian tubes, usually due to an STI. Tubo-ovarian abscess (TOA): A complication of PID that results from collected fluid and bacteria in the fallopian tube with possible extension to the ovary.

Gonorrhea Epidemiology According to the 2005 STD Surveillance Report of the Centers for Disease Control and Prevention (CDC), the gonorrhea rates per 100,000 individuals were 625 for females aged 15–19 years, 261 for males 15–19 years,

Gonorrhea, Chlamydia, and Pelvic Inflammatory Disease 195



581 for females 20–24 years, and 437 for males 20–24 years. Among incarcerated youth younger than 18 years, the prevalence rates were 6 per 100 females and 1 per 100 males. Direct medical costs in 2000 of gonococcal infection in individuals aged 15–24 years were an estimated $77 million. The high rate of coinfection with N. gonorrhoeae and C. trachomatis has prompted recommendations to treat empirically for both organisms if test results for one are positive and results for the other are unknown or unavailable. In a study of 5877 high school students aged 14–20 years who were tested for both gonorrhea and chlamydia, 43% of those with gonorrhea also had chlamydia and 11% with chlamydia also had gonorrhea. In a study of incarcerated youth, 54% of females and 51% of males with gonorrhea also had chlamydia. Risk factors for gonorrhea include young age, new or multiple sexual partners, minority race/ethnicity, ­substance use, and past gonorrhea. The likelihood of male-to-female transmission after one episode of sexual intercourse is 50–75% and may increase to more than 90% with repeated exposure. There are many strains of N. gonorrhoeae, and the predominant strains differ across regions of the United States. Approximately 20% of strains in the United States are resistant to penicillin and/ or tetracycline. Resistance to fluoroquinolone antibiotics was first detected in the United States in 1991 and has continued to increase over time. In 2005, nearly 10% of all isolates received by the CDC were quinolone resistant, leading to recommendations to discontinued use of these antibiotic for gonorrhea treatment.

Pathophysiology N. gonorrhoeae adheres to mucosal columnar epithelial cells, activates endocytosis, and replicates in both anaerobic and aerobic settings. Most strains of N. gonorrhoeae are killed by complement activation in the serum. Those that are resistant to host defenses appear to be more likely to cause epididymitis, PID, and intravascular ­dissemination. An estimated 90% of males with gonorrhea develop symptoms. The average incubation time is 8 days, with a range of 2–14 days. The most common presenting complaints are a purulent or mucopurulent urethral discharge and/or dysuria. Epididymitis, presenting as testicular pain and swelling, is more commonly due to chlamydia than gonorrhea. Anorectal gonorrhea occurs in males who have anoreceptive intercourse and, compared to urethral or pharyngeal gonorrhea, is associated with a three-fold risk of human immunodeficiency virus (HIV) infection. Pharyngeal infection with N. gonorrhoeae occurs in less than 10% of adult men who are heterosexual and in 10–25% of adult men who are homosexual or bisexual. Although it can cause pharyngitis and/or lymphadenitis, many oropharyngeal infections are asymptomatic.

In females, gonorrhea most commonly infects the cervix. Of the 50% of infected women who develop symptoms, the usual presenting complaints are vaginal discharge and/or pruritis. Less commonly, gonorrhea in females presents as dysuria secondary to urethritis. Anorectal gonorrhea in females may represent inoculation from vaginal secretions and is asymptomatic in 97% of cases. As in males, pharyngeal gonorrhea in females is usually asymptomatic. Infections of Bartholin’s or Skene’s glands with N. gonorrhoeae are nearly always symptomatic and usually are accompanied by cervical infection. PID associated with gonococcal infection is discussed later. Dissemination of N. gonorrhoeae via the bloodstream is three times more likely to occur in females than males, perhaps because of the higher rates of asymptomatic and untreated infections in females. Other factors associated with disseminated gonococcal infection (DGI) include menstruation, pregnancy, complement deficiencies, and systemic lupus erythematosus. DGI tends to present as either a triad of tenosynovitis, polyarthralgias, and characteristic skin lesions or as purulent arthritis. The skin lesions typically are painless; limited in number; located on the distal extremities; vary from macules to pustules to necrotizing ulcers; and may disappear within a few days, even without antibiotic treatment. In contrast, the joint symptoms usually are persistent and severe until antibiotics are begun, at which point resolution is ­dramatic (see Management, later).

Evaluation Laboratory methods for the identification of N. gonorrhoeae include Gram stain, culture, and DNA assays (see Box 26-1). The choice of test depends on patient gender, specimen site, transport conditions, and population prevalence. Table 26-1 summarizes the sensitivities and specificities of the various tests in adolescent females and males. Gram stain is sensitive and specific for the detection of N. gonorrhoeae in specimens collected from the male Box 26-1  Clinical Evidence of Gonorrhea Suggestive l

l

Mucopurulent endocervical or urethral discharge and Exposure to sexual partner with N. gonorrhoeae

Diagnostic l l l

l

Gram stain of male urethra or Culture of male urethra, endocervix, pharynx, or rectum Nucleic acid amplification test (NAAT) of male urethra, endocervix, or urine Nucleic acid hybridization of male urethra or endocervix

196 Adolescent Medicine: The Requisites in Pediatrics

Table 26-1 Sensitivities and Specificities of Laboratory Tests for Neisseria gonorrhoeae in Female and Male Adolescents Sensitivity (%)

Specificity (%)

Females   Endocervical culture   Endocervical NAAT1   Urine NAAT

70–93 95–99 56–91

100 99 99

Males   Urethral gram stain   Urethral culture   Urethral NAAT   Urine NAAT

81–94 72–95 96 90

94–97 99 99 99

NAAT, nucleic acid amplification test.

1

urethra but is unreliable for specimens from other sites because of the presence of nonpathogenic gram-negative diplococci. Culture on Thayer-Martin medium remains the gold standard for diagnosis but requires specimens obtained by swab (e.g., endocervix, urethra, pharynx, or rectum); prompt inoculation into an appropriate medium; and incubation in a controlled environment.  An important advantage of culture is the ability to assess the strain and antibiotic sensitivities of the organism. Nucleic acid amplification tests (NAATs) replicate the DNA or RNA sequences of N. gonorrhoeae. Its advantages include high sensitivity and specificity in male urethral, male urine and female endocervical specimens, and rapid results. Disadvantages are expense, lower sensitivity and specificity in female urine than in endocervical specimens, possibly lower sensitivity of urine in asymptomatic males, and lack of antibiotic sensitivity data.

Sexually active adolescents who are asymptomatic, including females who identify themselves as homosexual, should be screened every 6–12 months for gonorrhea (Table 26-2) and tested if symptoms develop in the interim. Noninvasive screening of asymptomatic males and females and testing of males with symptoms of urethritis can be performed by urine NAAT. However, CDC recommendations for testing preferences include culture of the urethra in a male as the first choice, followed by NAAT of the urethra or urine. In females, the first choice is culture of the endocervix followed by NAAT or nonamplified nucleic acid hybridization testing of the endocervix. Urine NAAT is acceptable when pelvic examination is not possible. However, females with symptoms of upper or lower genital tract infection should have a pelvic examination to obtain an endocervical specimen. Symp­ toms suggesting pharyngeal or anorectal gonorrhea warrant site-specific culture because NAATs are not appro­ved for these sites.

Management CDC recommendations are shown for the treatment of cervical, urethral, and anorectal gonorrhea in Box 26-2, oropharyngeal gonorrhea in Box 26-3, and disseminated gonorrhea in Box 26-4. Due to the increasing prevalence of quinolone resistance, as of April 2007, the CDC no longer recommends fluoroquinolones for GC treatment anywhere in the United States. For pharyngeal infections, recommended treatment is with ceftriaxone, due to Box 26-2 CDC Recommendations for the

Treatment of Uncomplicated Gonococcal Infections of the Cervix, Urethra, and Rectum

First-Line

Table 26-2 Screening Tests for Gonorrhea and Chlamydia

l l

Gonorrhea

Chlamydia

Females

Males

Endocervical culture Endocervical NAAT1 or nucleic acid hybridization Urine NAAT Endocervical NAAT Urine NAAT Endocervical nonNAAT test Endocervical culture

Urethral culture Urethral NAAT or nucleic acid hybridization Urine NAAT Urethral NAAT Urine NAAT Urethral non-NAAT test Urethral culture

NAAT, nucleic acid amplification test. Johnson RE, Newhall WJ, Papp JR et al.: Screening tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae infections. MMWR Recomm Rep 2002;51 (RR-15):1–38.

l

l

Cefixime 400 mg orally in a single dose or Ceftriaxone 125 mg IM in a single dose PLUS If chlamydia is not ruled out, azithromycin 1 g orally in a single dose or Doxycycline 100 mg orally twice a day for 7 days

Alternative l l l l l

1

l

Spectinomycin1 2 g IM in a single dose or Ceftizoxime 500 mg IM in a single dose or Cefoxitin 2 g IM with probenecid 1 g or Cefotaxime 500 mg IM in a single dose PLUS If chlamydia is not ruled out, azithromycin 1 g orally in a single dose or Doxycycline 100 mg orally twice a day for 7 days

Spectinomycin is not currently available in the United States.

1

Gonorrhea, Chlamydia, and Pelvic Inflammatory Disease 197



Box 26-3 CDC Recommendations for the

Treatment of Uncomplicated Gonococcal Infections of the Pharynx

l l

l

Ceftriaxone 125 mg IM in a single dose PLUS If chlamydia is not ruled out, azithromycin 1 g orally in a single dose or Doxycycline 100 mg orally twice a day for 7 days

Box 26-4 CDC Recommendations for

the Treatment of Disseminated Gonococcal Infections

First-Line l

Ceftriaxone 1 g IM or IV every 24 hours

Alternative •l

•l

•l

•l

•l

•l

Cefotaxime 1 g IV every 8 hours or Ceftizoxime 1 g IV every 8 hours or Ciprofloxacin 400 mg IV every 12 hours or Ofloxacin 400 mg IV every 12 hours or Levofloxacin 250 mg IV daily or Spectinomycin1 2 g IM every 12 hours

l

Cefixime 400 mg orally twice daily or Cefpodoxime 400 mg orally twice daily

Chlamydia Epidemiology In 2000, the 1.5 million cases of Chlamydia trachomatis among U.S. individuals aged 15–24 years accounted for $248 million in direct medical costs. The estimated prevalence rates of chlamydia in 2000 among adolescents younger than age 20 years were 4–8% for males and 10–11% for females. In 2003, the prevalence of chlamydia among incarcerated males and females younger than age 18 years was 5% and 16%, respectively. Of those with chlamydia, 13% of males and 18% of females were coinfected with gonorrhea. The rate of transmission from asymptomatic males to female sexual partners is approximately 65%. Risk factors for acquisition of chlamydia are similar to those for gonorrhea, with young age accounting for the highest proportion of risk.

Pathophysiology To be continued for 24–48 hours after improvement begins, followed by one of the subsequent regimens below

Subsequent l

3 weeks after treatment due to shedding of nonviable organisms.

To be completed at least one week of antimicrobial therapy

Spectinomycin is not currently available in the United States.

1

­ ifficulty with microbial eradication with other regimens. d For management of patients with penicillan or cephalosporin allergies, please consult the CDC website (www. edc.gov/STD/treatment). Patients should be advised to abstain from sexual activity for 7 days after treatment and encouraged to use condoms thereafter. Sexual partners from the preceding 60 days need referral to medical care for evaluation and treatment. No test of cure is required following treatment with any of the recommended regimens. Nonculture laboratory tests for N. gonorrhoeae, such as NAAT, may be falsely positive in adequately treated individuals for up to

C. trachomatis is an obligate intracellular gram-negative bacterium. Small forms of the organism, called elementary bodies, penetrate columnar epithelial cells of the urethra, endocervix, rectum, pharynx, and conjunctiva. The elementary bodies transform within the cell into reticulate bodies, which then reorganize into new elementary bodies. When the cell ruptures 2–3 days later, these new elementary bodies infect other cells, thus perpetuating the infection. The long replication cycle explains why longer courses of antibiotics are required for chlamydia than gonorrhea. The intracellular transformation of the organism probably contributes to the shortlived immunity to infection and the high rates of reinfection. An estimated 40% of males with nongonococcal urethritis (NGU) are asymptomatic, and chlamydia probably accounts for up to a third of NGU cases. When symptoms develop, the incubation period of 5–10 days is somewhat longer than that of gonorrhea and the dysuria and discharge tend to be milder. C. trachomatis can cause other syndromes in males, including proctitis, epididymitis, prostatitis, and Reiter syndrome (i.e., conjunctivitis, urethritis, and arthritis). More than 50% of females with chlamydia are asymptomatic. When symptoms develop, the most common are vaginal discharge, lower abdominal pain, and/or dysuria. Chlamydia can infect the Bartholin’s glands (with or without coexistent gonococcal infection), endometrium, fallopian tubes, and perihepatic region. Reiter syndrome occurs in females, although much less commonly than in males.

198 Adolescent Medicine: The Requisites in Pediatrics

Lymphogranuloma venereum (LGV) is a disease caused by three types of C. trachomatis and is rarely seen in developed countries. The usual presenting manifestation is tender inguinal or femoral lymphadenopathy, often preceded by a transient genital ulcer. The diagnosis is ­confirmed by complement fixation > 1:64.

Nonculture tests for chlamydia can be falsely positive up to 3 weeks after appropriate treatment due to shedding of nonviable bacteria. When repeat testing following treatment is positive, however, the most likely explanation is reinfection. A survey of adolescents recently treated for chlamydia revealed that 25% had not notified sexual partners of the need for treatment.

Evaluation Multiple testing methods exist for the diagnosis of chlamydia. Compared with the limited sensitivity of chlamydia culture (50–85%), NAAT has demonstrated a consistently high sensitivity of 97% for endocervical samples. The CDC recommends annual chlamydia screening (Table 262) for all sexually active females aged 25 years and younger with NAAT of endocervical specimens (preferred) or urine specimens (alternative). Nonamplified nucleic acid hybridization testing, enzyme immunoassays, and direct fluorescent antibody testing of endocervical samples have lower sensitivities of 70–85%. For chlamydia testing of males, the CDC recommends NAAT of urethral swabs or urine as first choice, with a urethral non-NAAT test or culture as alternatives.

Management CDC recommendations for the treatment of chlamydia are summarized in Box 26-5. Single-dose azithromycin, although more costly than doxycycline, is more costeffective due to improved compliance and directly observed therapy. Patients should be advised to abstain from sexual activity for 7 days and encouraged to use condoms thereafter. Sexual partners during the 60 days preceding treatment require evaluation and treatment. Test of cure is not necessary following singe-dose azithromycin or the 7-day course of doxycycline because of their high efficacy but might be considered following use of an alternative regimen.

Box 26-5 CDC Recommendations for the

Treatment of Chlamydia

First-Line l l

Azithromycin 1 g orally in a single dose or Doxycycline 100 mg orally twice daily for 7 days

Pelvic Inflammatory Disease Pelvic inflammatory disease (PID) is a polymicrobial infection of the upper genital tract that involves the endometrium, parametrium, fallopian tubes (i.e., salpingitis), and ovaries. Although more than half of cases begin with chlamydial or gonococcal cervicitis, the pathogenesis of PID depends on the ascension of multiple organisms from the vagina, through the inflamed cervix, and into the normally sterile environment of the upper ­genital tract.

Epidemiology PID represents a spectrum of disease with a wide range of severity and sequelae. An estimated 60% of PID cases are subclinical, 36% are mild to moderate in severity, and 4% require hospitalization. The likelihood of PID is inversely related to adolescent age, with a dramatic decline in risk by young adulthood. A study of females attending an urban teen clinic over an 18-month period revealed that 10% were diagnosed with PID. Furthermore, 47% of those diagnosed with PID had more than one episode prior to or during the study follow-up period. Given the high risk of adverse sequelae following untreated PID, the CDC relaxed its diagnostic guidelines between 1998 and 2002. A study comparing the rates of PID among sexually active females admitted to a juvenile detention center before and after the CDC change revealed an increase from 5% to 9%, suggesting that more subjects met criteria for diagnosis under the new guidelines. PID is more likely to develop during menses, following instrumentation of the upper genital tract, and with insertion of an intrauterine device. Oral contraceptive use appears to protect against the development of PID by as much as seven-fold, perhaps by increasing the viscosity of the cervical mucous or decreasing the myometrial contractility that propels organisms upward.

Alternate l

l

l l

Erythromycin base 500 mg orally 4 times daily for 7 days or Erythromycin ethylsuccinate 800 mg orally 4 times daily for 7 days or Ofloxacin 300 mg orally 2 times daily for 7 days or Levofloxacin 500 mg once daily for 7 days

Pathophysiology An analysis of PID cases compiled from 20 studies ­conducted worldwide revealed evidence of cervical infection with C. trachomatis in 29% of cases and N. gonorrheoae in 26%. Laparoscopic studies demonstrate that Bacteriodes and other anaerobes are the most

Gonorrhea, Chlamydia, and Pelvic Inflammatory Disease 199



c­ ommon organisms isolated from the upper genital tract of women with PID, regardless of the presence or absence of cervical gonorrhea or chlamydia. Other organisms implicated in the pathogenesis of PID include Escherichia coli and other gram-negative rods, Gardnerella vaginalis, Mycoplasma hominis, and Ureaplasma urealyticum. The pathogenesis of acute PID begins with inflammatory disruption of the cervical barrier, facilitating ascension of vaginal microorganisms into the normally sterile environment of the endometrium. The spread from the vagina to the uterus is most likely to occur during menstruation when the cervical os is open and the mucus plug is absent. It is also hypothesized that menstrual blood promotes bacterial growth and that the myometrial contractions of dysmenorrhea propel bacteria from the uterus into the fallopian tubes. As a result of the infection, plasma cells infiltrate the endometrium and inflammation decre­ ases tubal motility, resulting in hydrosalpinx (i.e., fluidfilled tube) formation. If treatment and resolution of the upper tract infection are delayed, the hydrosalpinx becomes pyosalpinx and infected contents spill from the fimbriated end of the tube into the peritoneal cavity. At this point, an abscess may organize between the tube and ovary or within the tube (i.e., tubo-ovarian abscess). Studies of adolescents with PID indicate that although 15–20% have tubo-ovarian abscesses (TOAs) on ultrasound, less than 30% of those with TOAs have palpable adnexal masses on bimanual examination. Once microorganisms have spilled into the peritoneum, infected material may track along the paracolic gutter and cause an inflammatory response of the hepatic ­capsule and diaphragm. The resulting perihepatitis, or Fitz-Hugh-Curtis syndrome, typically presents as right upper quadrant and/or subscapular pain, associated with pelvic pain. Liver function studies usually are normal or demonstrate only mild elevations of the transaminases. Long-term sequelae of PID include pelvic scarring and adhesions, ectopic pregnancy, infertility, and chronic pelvic pain. The likelihood of infertility increases from 8% after one episode of PID to 43% following three or more episodes. Prompt antibiotic therapy that provides broad coverage, as noted in following discussions, appears to decrease the risk of complications and sequelae.

Box 26-6 CDC Criteria for the Diagnosis

of PID

Minimum (i.e., at least one of the following) l l

Supportive (i.e., not required for diagnosis) l l l

l l l

The CDC guidelines for the diagnosis of PID (Box 26-6) encourage clinicians to err on the side of overdiagnosis rather than to risk missing the diagnosis or delaying treatment. Clinical diagnoses of PID have a positive predictive value (PPV) of 65–90% when compared with laparoscopy. The PPV tends to be highest among sexually active adolescents and other populations with high rates of gonorrhea or chlamydia. Because the initiation of antibiotics for PID is unlikely to interfere with the management of other causes

Oral temperature > 38.3° C (> 101° F) Abnormal cervical or vaginal mucopurulent discharge White blood cells on saline microscopy of vaginal secretions Elevated erythrocyte sedimentation rate Elevated C-reactive protein Laboratory documentation of cervical infection with N. gonorrhoeae or C. trachomatis

of pelvic pain (Box 26-7), the CDC recommends that a finding of either uterine/adnexal tenderness or cervical motion tenderness is sufficient for a diagnosis of PID in a female who is at risk for STIs and who does not have another identifiable cause for her symptoms. The additional criteria noted in Box 26-6 support, but are not required for, a diagnosis of PID. The most conclusive evidence of PID comes from endometrial biopsy, pelvic imaging, or laparoscopy. These findings include endometritis on histopathology, tubal thickening or fluid on ultrasound or magnetic resonance imaging (MRI), and infection on

Box 26-7  Differential Diagnosis of PID Gynecological l l l l l

Ectopic pregnancy Ovarian torsion Ovarian cyst or mass Endometriosis Dysmenorrhea

Gastrointestinal l l

Evaluation

Uterine/adnexal tenderness Cervical motion tenderness

l l l l l l

Appendicitis Appendiceal abscess Gastroenteritis Constipation Diverticulitis Irritable bowel syndrome Inflammatory bowel disease Cholelithiasis or cholecystitis (symptoms similar to perihepatitis)

Renal l l

Stone Urinary tract infection

200 Adolescent Medicine: The Requisites in Pediatrics

laparoscopy. However, as noted previously, the diagnosis and treatment of PID does not depend on these findings. Furthermore, endometrial biopsy is rarely indicated in the adolescent because of the near-zero risk of endometrial cancer. Pelvic ultrasound, particularly if done both transabdominally and transvaginally, can help establish the diagnosis of PID and identify a TOA. However, ultrasound is primarily used to exclude other pelvic pathology rather than confirm the clinical diagnosis of PID. Laparoscopy is rarely indicated for the adolescent with suspected acute PID but may be helpful in the evaluation of an adolescent with chronic pelvic pain (Chapter 24).

Management Empirical antibiotic therapy for PID should provide broad coverage against N. gonorrhoeae, C. trachomatis, gramnegative bacteria, anaerobes, and streptococci, regardless of microbiology test results. Indications for hospitalization according to CDC treatment guidelines include potential surgical emergency, pregnancy, unresponsiveness or inability to tolerate outpatient therapy, and TOA (Box 26-8). Of note, the CDC no longer recommends hospitalization for adolescents with PID unless they meet one or more of these indications. Although at least 24 hours of inpatient therapy and observation are generally recommended for patients with TOA, regardless of age, there is no firm evidence documenting its superiority to outpatient care for patients who are able to adhere to prescribed antibiotics and close follow-up. A randomized trial of inpatient parenteral vs. outpatient oral antibiotics for mild to moderate PID without TOA in adolescents and adults revealed no significant differences in the rates of symptom resolution, TOA formation, recurrence, ectopic pregnancy, infertility, or chronic pelvic pain over 35 months of follow-up. CDC recommendations for parenteral and oral antibiotic regimens are summarized in Boxes 26-9 and 26-10. Due to increased resistance, fluoroquinolones are no longer recommended as part of PID treatment regimens. However, if the patient has a low risk of GC infection and the community prevalance of resistant GC is low,

Box 26-8 CDC Indications for the

Hospitalization of Patients with Suspected PID

l l l l l l

Possible surgical emergency (e.g., appendicitis) Pregnancy Unresponsiveness to oral antibiotics Inability to adhere to or tolerate outpatient therapy Severe illness (e.g., vomiting, high fever, intractable pain) Tubo-ovarian abscess

Box 26-9 CDC Recommendations for the

Intravenous (IV) Treatment of PID

First-Line Regimens

A. Cefotetan 2 g IV every 12 hours or cefoxitin 2 g IV every 6 hours plus doxycycline 100 mg orally (or IV ) every 12 hours (avoid IV doxycycline if possible) B. Clindamycin 900 mg IV every 8 hours plus gentamicin 2 mg/kg load followed by 1.5 mg/kg every 8 hours Alternative Regimens

C. Ampicillin/sulbactam 3 g IV every 6 hours plus doxycycline 100 mg orally (or IV ) every 12 hours

Box 26-10 CDC Recommendations for

the Oral or Intramuscular (IM) Treatment of PID

Ceftriaxone 250 mg IM one dose or cefoxitin 2 g IM one dose with probenecid 1 g orally or other parenteral third-generation cephalosporin and doxycycline 100 mg orally twice daily for 14 days with or without metronidazole 500 mg orally twice daily for 14 days

quinolones may be considered if GC culture and antibiotic sensitivities are obtained prior to initiation of therapy. Quinolones should not be used if non-culture GC testing is used or if antibiotic susceptibility testing is not available. If antibiotics are begun intravenously (IV), they can be discontinued 24 hours after clinical improvement and the total 14-day course can be completed with either oral doxycycline or oral clindamycin alone. Clindamycin is preferred over doxycycline for the patient with a TOA because of its anaerobic coverage. Although doxycycline can be administered IV, oral is preferred whenever possible because of the venous inflammation and pain associated with the infusion. All CDC treatment recom­men­dations are subject to change, depending on the prevalent organisms in the population and their patterns of antibiotic sensitivity. It therefore is important to check the CDC website periodically for updates (http://www.cdc.gov/std). Follow-up examination within 3 days of beginning antibiotics is essential for all patients with PID. If signs and symptoms have not improved considerably by that time, hospitalization is recommended for IV therapy and/ or additional evaluation. Male sexual partners who had contact with patients with PID within 60 days of diagnosis should be treated for urethral gonorrhea and ­chlamydia,

Gonorrhea, Chlamydia, and Pelvic Inflammatory Disease 201



 l

l

l

l

l

l

l

Major Points

b

Gonorrhea and chlamydia infections are often asymptomatic. Routine screening of all at-risk adolescents is recommended at least yearly. Consider gonorrhea or chlamydia infection in females who present with urinary symptoms. PID is a clinical diagnosis that should be considered in any sexually active female with uterine/adnexal tenderness and/or cervical motion tenderness. Early, broad-spectrum antibiotic therapy for PID decreases the likelihood of long-term complications. Early and appropriate antibiotic therapy is necessary to prevent the long-term consequences of PID. Diagnostic and treatment guidelines are compiled by the CDC for all STIs and are available online at http://www.cdc.gov. The web site should be checked frequently for updates.

Catallozzi M, Rudy BJ: Lesbian, gay, bisexual, transgendered, and questioning youth: The importance of a sensitive and confidential sexual history in identifying the risk and implementing treatment for sexually transmitted infections. Adolesc Med Clin 2004;15:353–367. Cook RL, Hutchison SL, Ostergaard L, et al.: Systematic review: Noninvasive testing for Chlamydia trachomatis and Neisseria gonorrhoeae. Ann Intern Med 2005;142:914–925. Ford CA, Pence BW, Miller WC, et al.: Predicting adolescents’ longitudinal risk for sexually transmitted infection: Results from the National Longitudinal Study of Adolescent Health. Arch Pediatr Adolesc Med 2005;159:657–664. Huppert JS, Biro FM, Mehrabi J, et al.: Urinary tract infection and Chlamydia infection in adolescent females. J Pediatr Adolesc Gynecol 2003;16:133–137. Kahn RH, Mosure DJ, Blank S, et al.: Chlamydia trachomatis and Neisseria gonorrhoeae prevalence and coinfection in adolescents entering selected US juvenile detention centers, 1997–2002. Sex Transm Dis 2005;32:255–259. Kelly AM, Ireland M, Aughey D: Pelvic inflammatory disease in adolescents: High incidence and recurrence rates in an urban teen clinic. J Pediatr Adolesc Gynecol 2004;17:383–388.

regardless of the presence or absence of symptoms or the results of microbiology testing.

Lim SW, Coupey SM: Are adolescent girls with Chlamydia infection notifying their partners? J Pediatr Adolesc Gynecol 2005;18:33–38.

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Bailey JV, Farquhar C, Owen C, et al.: Sexually transmitted infections in women who have sex with women. Sex Transm Infect 2004;80:244–246. Banikarim C, Chacko MR: Pelvic inflammatory disease in adolescents. Adolesc Med Clin 2004;15:273–285. Beckmann KR, Melzer-Lange MD, Gorelick MH: Emergency department management of sexually transmitted infections in US adolescents: Results from the National Hospital Ambulatory Medical Care Survey. Ann Emerg Med 2004;43:333–338. Braverman PK, Schwarz DF, Deforest A, et al.: Use of ligase chain reaction for laboratory identification of Chlamydia trachomatis and Neisseria gonorrhoeae in adolescent women. J Pediatr Adolesc Gynecol 2002;15:37–41.

Risser WL, Cromwell PF, Bortot AT, et al.: Impact of new diagnostic criteria on the prevalence and incidence of pelvic inflammatory disease. J Pediatr Adolesc Gynecol 2004;17: 39–44. Spigarelli MG, Biro FM: Sexually transmitted disease testing: Evaluation of diagnostic tests and methods. Adolesc Med Clin 2004;15:287–299. Tebb KP, Shafer MA, Wibbelsman CJ, et al.: To screen or not to screen: Prevalence of C. trachomatis among sexually active asymptomatic male adolescents attending health maintenance pediatric visits. J Adolesc Health 2004;34:166–168.

27

Ch A p t e r

Introduction Definitions Pathophysiology Epidemiology Evaluation Anogenital Warts Cervical Cancer Screening

Management Genital Warts Abnormal Pap Tests Colposcopy Patient Education

HPV Vaccines

Introduction Human papillomavirus (HPV) is one of the most common sexually transmitted infections (STIs) worldwide. Although usually sub-clinical, HPV infection may cause abnormal Papanicolaou (Pap) tests, genital condylomata (warts), cervical dysplasia, and cervical cancer. Of the 100 HPV types that have been identified, approximately 40 of these infect the genital tract. These are classified as high-risk types, which may cause abnormal Pap tests and anogenital cancers, and lowrisk types, which may cause genital warts. New information about the natural history of HPV infection in adolescent and young adult women and new technologies for Pap and HPV testing have led to revised recommendations for cervical cancer screening and prevention. Prophylactic HPV vaccines may become a highly effective strategy for prevention of HPV infection and HPV-related disease.

202

Human Papillomavirus and Cervical Dysplasia Giselle schneider, MD, MS Jessica A. Kahn, MD, MPH

Definitions HPV: Human papillomavirus is a DNA virus of the Papillomaviridae family that preferentially infects epithelial cells. Cutaneous HPV: Types of HPV that cause plantar and common skin warts. Mucosal HPV: High-risk and low-risk types of HPV that infect the epithelium of the anogenital and aerodigestive tracts. Low-risk HPV: Types 6, 11, 40, 42, 43, 44, 54, 61, 70, 72, and 81 may cause abnormal Pap tests, genital warts (i.e., genital condylomata), and recurrent respiratory papillomatosis. High-risk HPV: Types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82 may cause cervical, other anogenital, oral, esophageal, head, and neck cancers. Type 16 causes 40–60% and type 18 causes 10–20% of cervical cancer. Recurrent respiratory papillomatosis (RRP): Rare complication of maternal-neonatal HPV transmission that may cause upper airway obstruction in infants and young children. Papanicolaou (Pap) test: Evaluates exfoliated cervical epithelial cells as a screening test for cervical cancer and yields a cytological diagnosis. Cervical ectopy: Normal extension of the endocervical columnar epithelium onto the ectocervix, commonly seen in adolescents. The transformation zone, where columnar cells are replaced by squamous epithelial cells, is particularly prone to HPV infection. Squamous metaplasia: Process in which columnar epithelial cells mature into squamous epithelium. Cervical dysplasia: Histological diagnosis of cervical intraepithelial neoplasia (CIN) made on cervical biopsy that ranges in severity from mild (CIN 1) to moderate (CIN 2) to severe (CIN 3, or carcinoma in situ).

Human Papillomavirus and Cervical Dysplasia 203



Pathophysiology Transmission of anogenital HPV occurs primarily through sexual intercourse when there is a break in the integrity of the skin or mucosal surface. Adolescents may be at higher risk than adult women for HPV infection because of cervical ectopy and squamous metaplasia (see previous), which facilitate HPV replication and protein expression. Hormonal factors, such as pregnancy, may increase the risk of HPV infection by maintaining the transformation zone of the ectocervix and may influence disease progression by modulating the host immune response to infection. Vertical transmission from infected mothers to neonates and transmission through casual, nonsexual contact can occur, but the rates are thought to be low. Figure 27-1 summarizes the classification system for HPV. More than 95% of genital warts and RRP contain HPV types 6 and/or 11. Almost all cervical cancers contain at least one high-risk HPV type, and approximately 70% contain types 16, 18, or both. Of note, terminology differs for the cytological diagnosis made on Pap test and the histological diagnosis made on cervical biopsy. The terminology for the cytological diagnosis is based on the 2001 Bethesda system (Table 27-1). Although cervical HPV infection and abnormal Pap tests are common, progression to cervical cancer is rare. There are two main reasons for this. First, effective Pap screening and treatment of CIN prevents progression from precancerous lesions to cervical cancer. Second, in most women with high-risk HPV, host immune responses appear to prevent the active viral replication required for persistent infection, which is a prerequisite for the development of high-grade squamous intraepithelial lesion (HSIL), CIN 2, CIN 3, and cervical cancer. The

median incubation period from initial HPV infection to ­carcinoma in situ is estimated to be 7 to 12 years. Most HPV infections in adolescent and young adult women are subclinical and resolve spontaneously. Prospective studies of adolescent females following infection demonstrate spontaneous clearing of low-risk HPV types in 90% of subjects at a median of 170 days, and of high-risk HPV types in 75% at a median of 226 days. The 10% of subjects with persistent high-risk HPV were 14 times more likely to develop HSIL than those who cleared the infection. The average time from infection to development of HSIL was 20 months. The high rate of spontaneous resolution of the infection, the long lag time between infection and dysplasia, and the widespread use of the Pap test explain why the incidence rates of cervical cancer in the United States are only 1.3/100,000 at ages 20–24 years and 0 at ages 15–19 years. The natural history of genital warts is unpredictable. They usually appear 2–3 months after infection, but viral latency within the cell can delay their appearance for years. Most resolve spontaneously over months to years, but their duration, size, and number are highly variable.

Epidemiology An estimated 20 million individuals in the United States are infected with sexually transmitted HPV, and 6 million new infections occur each year. Initial visits to physicians’ offices for genital warts rose from 56,000 in 1966 to 264,000 in 2003, and U.S. health care costs associated with HPV-related disease now exceed $6 billion dollars annually. HPV prevalence is highest among sexually active adolescent and young adult women (51–82%) and then declines over the third to sixth decades of life. Among U.S.

HPV types

Cutaneous

Mucosal

Figure 27-1 Classification of HPV types. Adapted from: Munoz N Bosch FX, de Sanjose S, et al.: Epidemiologic classification of human papillomavirus types associated with ­cervical cancer. N Engl J Med 2003;348:518–527.

Low-risk 6, 11, 40, 42, 43, 44, 54, 61, 70, 72, and 81

High-risk 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 68, 73, and 82

Genital condylomata

Cervical dysplasia, carcinoma

204 Adolescent Medicine: The Requisites in Pediatrics

Table 27-1 Classification of Cervical Cytology Results by the Bethesda Systema Category

Classification

I. Specimen adequacy

A.  B.  A.  B.  A.    B.   

Satisfactory for evaluation Unsatisfactory for evaluation Negative for intraepithelial lesion or malignancy Epithelial cell abnormality Negative for intraepithelial lesion or malignancy (including infectious organisms and reactive cellular changes associated with inflammation) Epithelial cell abnormalities 1.  Squamous cell    a.  Atypical squamous cells (ASC)b of undetermined significance (ASC-US) cannot exclude high-grade squamous intraepithelial lesion (ASC-H)    b.  Low-grade squamous intraepithelial lesion (LSIL). Includes HPV, mild dysplasia, and CINc 1    c.  High-grade squamous intraepithelial lesion (HSIL). Includes moderate and severe dysplasia, CISd, CIN 2, CIN 3    d.  Squamous cell carcinoma   2.  Glandular cell    a.  Atypical glandular cells (AGC)    b.  Atypical glandular cells, favor neoplastic    c.  Endocervical adenocarcinoma in situ (AIS)

II. General categorization III. Interpretation/Result

Revised 2001. In the revised Bethesda System, the category previously termed ASCUS (atypical squamous cells of undetermined significance) is subdivided into ASC-US and ASC-H. c Cervical intraepithelial neoplasia. d Carcinoma in situ. Adapted from: Solomon D, Davey D, Kurman R et al.:The 2001 Bethesda System:Terminology for reporting results of cervical cytology. JAMA 2002;287:2114–2119. a

b

Never (25%)

Genital warts (1%)

Currently (15%)

Figure 27–2 Prevalence of genital HPV infection in U.S. population aged 15–49 years. Adapted from: Koutsky L: Epidemiology of genital human papillomavirus infection. Am J Med 1997;102:3–8.

Abnormal Pap tests (4%)

Previously (60%) All Individuals

DNA/RNA + (10%) Currently Infected Individuals

males and females age 15–49 years, 60% were previously infected with HPV, 15% are currently infected, and 25% are uninfected. Of the 15% currently infected, 10% have subclinical infection as evidenced by HPV DNA or RNA positivity. Another 1% have genital warts, and 4% have abnormal cervical cytology (Figure 27-2). Risk factors for HPV infection and the progression of HPV-related disease are noted in Boxes 27-1 and 27-2, respectively. Although condom use may not protect

against HPV infection, consistent use promotes viral clearance and decreases the likelihood of HPV-related disease. HIV infection and organ transplantation with resulting T-cell deficiency, T-cell dysfunction, and altered cytokine expression are important risk factors for HPV infection and the development of HPV-related disease. Prevalence trends by age for HPV-related abnormal Pap tests depend on the specific cytological result. The trend for low-grade squamous intraepithelial lesion (LSIL)

Human Papillomavirus and Cervical Dysplasia 205



Box 27-1  Risk Factors for HPV Infection l l l l l l l

Young age at first intercourse Older partner age Increased numbers of partners and partners’ partners Sexual abuse Herpes simplex virus 2 (HSV-2) infection Cigarette smoking Immunosuppression

Box 27-2 Risk Factors for the Develop-

ment of HPV-Related Disease

l l l l l l l l

Immunosuppression No or inconsistent condom use Deficiency of micronutrients (e.g., folate) Hormonal contraception Pregnancy and parity HSV-2 and/or chlamydia infection Cigarette smoking Viral factors (e.g., HPV genotype, viral load)

ASC-US

Percentage

8 ≥ CIN 3

6 4

Evaluation The evaluation of an adolescent with known or suspected HPV infection begins with a history and physical examination. The history should explore risk factors for HPV acquisition, transmission, and disease development. The evaluation of a patient with anogenital warts and recommendations for cervical cancer screening during adolescence are discussed later.

Anogenital Warts

12 10

20s to 50s. Despite a dramatic decline in the incidence of cervical cancer over the past 50 years due to widespread Pap screening and treatment of precancerous lesions, cervical cancer is still the fourth most commonly diagnosed cancer among women in more developed regions of the world and the second most commonly diagnosed cancer among women in less developed countries.

HSIL

2 LSIL

HPV-related anogenital warts may appear as cauliflowershaped growths (i.e., condylomata acuminata); smooth, raised papules; thick keratoses resembling common skin warts; and/or small, flat-topped lesions (Box 27-3 and Figure 27-4). In women, they may occur on the vulva, vagina, cervix, perineum, and perianal areas. In men, they may occur on the inner surface of the prepuce, frenulum, penile shaft, glans, scotum, and anus. Genital warts are usually asymptomatic but occasionally cause pruritus, burning, pain, bleeding, or vaginal discharge. The differential diagnosis of genital warts includes micropapillomatosis labialis, pearly penile papules, seborrheic keratosis, condyloma latum (i.e., secondary syphilis), molluscum contagiosum, and granuloma inguinale. Micropapillomatosis labialis involves the labia majora and consists of small papular projections, each with its own separate base, which differentiates it from condylomata acuminata. Pearly penile papules occur on the corona and are considered a normal finding. Seborrheic keratoses are wartlike, pigmented, benign, and usually asymp-

0 18–19

20–24

25–29

30–34

35–50

Age

Figure 27–3 Cervical cytology by age. Adapted from: Kulasingam SL, Hughes JP, Kiviat NB, et al.: Evaluation of human papillomavirus testing in primary screening for cervical abnormalities: Comparison of sensitivity, specificity, and frequency of referral. JAMA 2002; 288:1749–1757.

is similar to that for HPV infection, with a decline in the third decade (Figure 27-3). Trends for HSIL and ASC-US remain relatively stable with age, whereas the prevalence of cervical carcinoma increases with age from the early

Box 27-3  HPV-Related Anogenital Warts Condylomata acuminate: Cauliflower-shaped   growths with finger-like   projections Papular: 1–4 mm, smooth, well   circumscribed Keratotic: Thick; resemble a common   skin wart Flat-topped papules: Small; difficult to detect

206 Adolescent Medicine: The Requisites in Pediatrics

Figure 27-4 Genital warts (photograph). Published previously in: Kahn JA, Hillard PA: Human papillomavirus and cervical cytology in adolescents. Adolesc Med Clin 2004;15:301–321.

tomatic. The mucocutaneous lesions of secondary syphilis may be difficult to distinguish from genital warts without laboratory testing. Molluscum contagiosum is a benign, self-limited eruption of multiple small, umbilicated, cutaneous papules. Granuloma inguinale is caused by sexual acquisition of Calymmatobacterium granulomatis and is diagnosed by the microscopic finding of Donovan bodies on tissue smear or biopsy. Lastly, vulvar intraepithelial neoplasia or cancer can be confused with genital warts. Biopsy of genital warts is usually not necessary unless the diagnosis is unclear or there is substantial hyperpigmentation, ulceration, or suspicion of cancer.

Cervical Cancer Screening Since the 1927 introduction of the Pap test, mortality from cervical cancer has decreased 70%. The major limitation of the Pap test is its false-negative rate due to errors in sampling and interpretation. Liquid-based cytological screening, such as ThinPrep 2000 (Cytyc Corporation, Marlborough, MA) and SurePath (TriPath Imaging, Burlington, NC), initially were thought to decrease the false-negative rate, but a recent meta-analysis revealed no improvement over conventional Pap tests. Con­sequently, the American Cancer Society (ACS) and the American College of Obstetricians and Gynecologists (ACOG) endorse both the traditional Pap and liquid-based testing. If the traditional Pap test is used for screening, it should be performed yearly. If liquid-based cytological testing is used, it may be performed every 2 years if noncompliance with follow-up is not a concern. Cervicography, or high-resolution photography of the cervix after application of acetic acid, is designed to enhance the diagnosis of severe dysplasia but is costly and of low predictive value in adolescents.

Evidence of the causal association between HPV infection, cervical dysplasia, and cervical cancer has led to the increasing use of HPV DNA testing as an adjunct to the Pap test. In women with ASC-US, HPV DNA testing is more sensitive than repeat Pap testing for the detection of high-grade cervical dysplasia (83% vs. 67%). DNA testing is not helpful in women with LSIL because 80% are positive for high-risk HPV types. Given these results, high-risk HPV DNA testing is now commonly used as an adjunct to Pap testing to determine which women with ASC-US should undergo colposcopy. Hybrid Capture II (Digene, Gaithersburg, MD) is a hybridization/signalamplification test that detects 13 high-risk HPV types and is commercially available in the United States. HPV DNA testing may offer a strategy for primary screening in parts of the world where pelvic examination for Pap testing is not feasible. Self-collected vaginal swabs yield test results similar to those of clinician­collected samples in both adults and adolescents. However, studies in the United States suggest that adults and adolescents differ in their preferences for self- vs. clinician-testing. Adult women prefer self-testing, whereas adolescents prefer clinician-testing and express concern about their ability to self-collect correctly. The ACS has issued special guidelines for cervical cancer screening in adolescents. The guidelines were developed in response to data demonstrating a difference in the natural history of HPV in adolescent and adult women. Although HPV infection is very common in sexually active adolescents, LSIL in adolescents usually regresses spontaneously and the development of cervical cancer during adolescence is extremely rare. The traditional initiation of Pap screening at the onset of sexual activity therefore might lead to unnecessary procedures to evaluate abnormal results. The revised ACS guidelines recommend the initiation of Pap screening 3 years after sexual initiation or by 21 years of age, followed by annual screening if the conventional Pap smear is used and testing every 2 years if the liquid-based Pap smear is used. ACOG guidelines also note that clinicians should consider the likelihood of sexual abuse, sexual risk behaviors, and adherence to ­ follow-up in deciding when to initiate screening. In adolescents newly diagnosed with human immunodeficiency virus (HIV) infection, the ACS recommends Pap testing twice in the year after diagnosis and, if negative, annually thereafter. If sexual abuse involving vaginal intercourse has occurred, a clinician accustomed to examining abused children and adolescents should initiate screening when the patient’s emotional and physical comfort allow the speculum examination. Regardless of an adolescent’s need for Pap testing, the ACS and ACOG emphasize the importance of providing routine STI screening, contraceptive counseling, and other preventive health care ­services.

Human Papillomavirus and Cervical Dysplasia 207



Management

There are two options for the home-based, patientapplied treatment of genital warts. One, not both, of the following options should be prescribed at any given time:

Genital Warts Spontaneous resolution of genital warts occurs in 40% of cases, and there is no evidence that treatment diminishes viral transmission. HPV-related genital warts are benign lesions, do not progress to malignancy, and should not be treated or removed in an effort to prevent cancer if the diagnosis is certain. However, if the diagnosis is uncertain and the lesion raises concern about vulvar intraepithelial neoplasia or squamous cell carcinoma, excisional biopsy is essential. This is particularly important in patients who are at increased risk for mucocutaneous malignancies, such as those with immunosuppression and HIV ­infection. Many patients with genital warts request treatment for cosmetic reasons or, less commonly, because of pain or itching associated with the lesions. After education about the natural history of genital warts and the transmission of HPV, patient- or clinician-applied treatment (but not both simultaneously) can be prescribed (Tables 27-2 and 27-3). Of note, topical 5-flourouracil cream, interferon, and podophyllin 10–25% resin are no longer ­recommended for the treatment of genital warts.

l

l

Podofilox 0.5% solution or gel is applied to genital warts twice daily for 3 days, followed by 4 days of no therapy. The total treated surface area should not exceed 10 cm2, and a maximum of 0.5 ml should be applied daily. Podofilox should not be used in the vagina or anus and is contraindicated in pregnancy. Imiquimod 5% cream is applied to genital warts 3 nights weekly for up to 16 weeks. Patients should be instructed to wash off the cream with soap and water the morning after application. There is no surface area limitation to its use. Imiquimod has not been evaluated for use in the vagina or anus, and its safety profile during pregnancy is unknown.

There are three options for the office-based treatment of genital warts by a clinician. Only one of the three options is indicated at any given time: l

Trichloroacetic acid 80–90% is applied to anogenital warts of the skin or mucosal surfaces of the vagina, cervix, penis, periurethra, perineum, and anus.

Table 27-2  Patient-Applied Treatment of Genital Warts Clearance Rates (%)

Recurrence Rates (%)

Podofilox 0.5% solution or gel

45–88

Imiquimod 5%   cream

27–54

Patient-Applied

Advantages

Disadvantages

4–38

May be applied at home. Easy to apply.

13–19

May be applied at home. Can be applied to new warts as they appear.

Possible toxic systemic effects. Not useful for cervical or mucosal lesions. Erosion, burning, pain, itching. Takes up to 16 weeks to treat. Local erythema, erosion, burning, pain, and itching.

Table 27-3  Provider-Applied Treatment of Genital Warts Clearance Rates (%)

Recurrence Rates (%)

Trichloroacetic acid or bichloroacetic acid 80–90% Cryotherapy

50–80

35

27–88

21–40

Surgical removal

35–72

19–29

Provider-Applied

Advantages

Disadvantages

Inexpensive. Easy to apply. Safe in pregnancy. Well-tolerated. Useful for most warts. Safe in pregnancy. Minimal scarring. Useful for extensive disease. Safe in pregnancy.

Pain on application. Destroys normal tissue if over-applied. Pain, necrosis, blistering. Overapplication leads to complications. Under-application leads to poor results. Expensive. Requires hospital setting and expertise. Scarring. Risk of bleeding.

208 Adolescent Medicine: The Requisites in Pediatrics l

l

Cryotherapy is indicated for the treatment of genital warts of the external genitalia and cervix but should be avoided in the vagina or anus because of possible fistula or scar formation. Nitric oxide is applied to warts of the external genitalia, and nitrous oxide is applied to warts of the cervix. Surgical removal or laser therapy is indicated for genital warts that are large, multifocal, or unresponsive to other therapies.

Abnormal Pap Tests Interpretation of the Pap test begins with an adequate cytological sample. A Pap test that reveals no endocervical cells should be repeated. If the Pap test reveals inflammation, the patient should be evaluated for sexually transmitted or other infections (e.g., vaginal candidiasis) and the Pap test should be repeated 2–3 months after appropriate treatment. The management of abnormal Pap tests has changed considerably since the availability of HPV DNA testing. Guidelines of the American Society for Colposcopy and Cervical Pathology (ASCCP), ACS, and ACOG for the management of immunocompetent patients with ASC-US, ASC-H, LSIL, and HSIL are summarized in the following discussion. Immunosuppressed or HIVinfected patients with these lesions should always be referred for prompt ­colposcopy. ASC-US: Recommendations for the management of adolescents with ASC-US on Pap testing have changed along with our understanding of the natural history of HPV infection in this age group. Given the likelihood of spontaneous resolution of high-risk HPV during adolescence, ACOG suggests that adolescents with ASC-US, even if positive for high-risk HPV types, may be followed with either repeat Pap testing at 6 and 12 months or a single HPV test at 12 months. Until late 2007, ASCCP ­recommended reflex HPV DNA testing for patients with ASC-US and colposcopy if the testing revealed high-risk HPV types. Revised recommendations, expected shortly, are expected to call for annual Pap testing without HPV testing and referral to colposcopy only if the Pap test is persistently abnormal for 24 months. ASC-H: Immediate colposcopy is recommended for adults and adolescents with Pap test results of atypical squamous cells in which HSIL cannot be excluded. LSIL: ASCCP and ACOG recommendations for the management of LSIL depend on patient age. For adults, colposcopy is recommended. For adolescents, revised recommendations are expected to follow the same path as that described above for ASC-US: annual Pap testing without HPV testing and referral to colposcopy only if the Pap test is persistently abnormal for 24 months.

HSIL: Immediate colposcopy is recommended for adults and adolescents with HSIL.

Colposcopy Colposcopy allows magnified examination of the cervix and lower genital tract for the detection and biopsy of epithelial lesions that are potentially dysplastic or malignant. It is particularly important to visualize the junction between the squamous epithelium of the ectocervix and the columnar epithelium of the endocervix. Adolescents should be encouraged to inform parents when colposcopy is recommended, and a preprocedure visit should allow adequate time for patient education, STI testing, and treatment of ­positive results. The treatment of CIN 2 or CIN 3 diagnosed on colposcopically directed biopsy depends on patient age, lesion size, and lesion distribution. ACOG guidelines state that adolescents with CIN 2 who adhere to followup visits can be followed with observation alone. Ablative or excisional therapy is indicated for adolescents with CIN 2 who cannot adhere to follow-up, all adolescents with CIN 3, and all adults with CIN 2 or CIN 3. Ablative procedures include cryotherapy and carbon dioxide laser. Excisional procedures include cold knife conization and loop electrosurgical excision procedure (LEEP).

Patient Education Although HPV infection is extremely common, the risk of acquiring HPV and developing HPV-related diseases can be decreased by practicing safe sexual behaviors and obtaining regular Pap screening. Health care providers must educate adolescents about HPV infection, its transmission, its sequelae, and prevention strategies. Adoles­ cents should understand that HPV infection is acquired through sexual contact, not necessarily penetrative sexual intercourse. Clinicians should encourage adolescents to postpone sexual initiation, limit their number of sexual partners, use condoms consistently, and avoid tobacco use. In addition, providers should provide clear recommendations for Pap screening.

HPV Vaccines Prophylactic HPV vaccines designed to prevent HPV acquisition may provide a strategy for primary prevention. Two types of vaccine have been developed. One is a bivalent vaccine designed to protect women against infection caused by Types 16 and 18 and is predicted to

Human Papillomavirus and Cervical Dysplasia 209



prevent 70% of cervical cancer in vaccinated females. The other is a quadrivalent vaccine that includes Types 6 and 11, as well as Types 16 and 18. It therefore could prevent most genital warts and RRP, as well as most ­cervical cancer. Both the bivalent and quadrivalent vaccines are comprised of capsid proteins from each of the component HPV types. These proteins can self-assemble into viruslike particles that induce a neutralizing antibody response. The vaccines do not contain any viral DNA and therefore cannot cause HPV infection or HPVrelated diseases. Clinical trials have demonstrated that both vaccines have few side effects, are well tolerated, and are highly effective in preventing HPV infection and HPV-related CIN. However, counseling patients about safe sexual behaviors and regular Pap screening remains important, because vaccines are not 100% protective against either HPV infection or the development of cervical cancer.



Major Points

b

In adolescence, HPV prevalence is high and infection occurs rapidly after sexual initiation. l Infection may be asymptomatic or transient, or lead to adverse sequelae. l HPV types 6 and 11 are the most common types associated with the development of external lesions such as genital warts. l HPV types 16 and 18 are the most common types associated with the development of abnormal cervical cytology and cervical cancer. l Adolescents should be screened for abnormal cervical cytology approximately 3 years after first sexual intercourse or by the age of 21 years, whichever occurs first. l HPV infection and LSIL have high rates of regression in the adolescent population. l Persistent infection with high-risk HPV types may lead to cervical cancer. l Adolescents should be educated about HPV ­infection, prevention, and potential sequelae. l HPV vaccination is likely to provide significant but incomplete protection against HPV infection and HPV-related disease. l The Centers for Disease Control and Prevention (http://www.cdc.gov) and the American Society for Colposcopy and Cervical Pathology (http://www. asccp.org) maintain up-to-date web sites on the evaluation and management of HPV-related disease. l

Bibliography American College of Obstetricians and Gynecologists: Eval­ uation and management of abnormal cytology and histology in the adolescent. Obstet Gynecol 2006;107:963–968. ASCUS-LSIL Triage Study (ALTS) Group: A randomized trial on the management of low-grade squamous intraepithelial lesion cytology interpretations. Am J Obstet Gynecol 2003;188: 1393–1400. Baseman JG, Koutsky LA: The epidemiology of human papil­ lomavirus infection. J Clin Virol 2005;32(Suppl 1): S16–S24. Brown DR, Shew ML, Qadadri B, et al.: A longitudinal study of genital human papillomavirus infection in a cohort of closely followed adolescent women. J Infect Dis 2005;191: 182–192. Collins S, Mazloomzadeh S, Winter H, et al.: High incidence of cervical human papillomavirus infection in women during their first sexual relationship. BJOG 2002;109:96–98. Harper DM, Franco EL, Wheeler C, et al.: Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: A randomized controlled trial. Lancet 2004;364:1757–1765. Hogewoning CJ, Bleeker MC, van den Brule AJ, et al.: Condom use promotes regression of cervical intraepithelial neoplasia and clearance of human papillomavirus: A randomized clinical trial. Int J Cancer 2003;107:811–816. Kahn JA, Hillard PA: Human papillomavirus and cervical cytology in adolescents. Adolesc Med Clin 2004;15:301–321. Kahn JA, Slap GB, Huang B, et al.: Comparison of adolescent and young adult self-collected and clinician-collected samples for human papillomavirus. Obstet Gynecol 2004;103(5 pt 1): 952–959. Moscicki AB, Shiboski S, Broering J, et al.: The natural history of human papillomavirus infection as measured by repeated DNA testing in adolescent and young women. J Pediatr 1998;132: 277–284. Munoz N, Bosch FX, de Sanjose S, et al.: Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med 2003;348:518–527. Tarkowski TA, Koumans EH, Sawyer M, et al.: Epidemiology of human papillomavirus infection and abnormal cytologic test results in an urban adolescent population. J Infect Dis 2004;189:46–50. Villa LL, Costa RL, Petta CA, et al.: Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: A randomized double-blind placebo-controlled multicentre phase II efficacy trial. Lancet Oncol 2005;6:256–257. Winer RL, Lee SK, Hughes JP, et al.: Genital human papilloma­ virus infection: Incidence and risk factors in a cohort of female university students. Am J Epidemiol 2003;157:218–226. Wright TC, Jr, Cox JT, Massad LS, et al.: 2001 consensus guide­ lines for the management of women with cervical cytological abnormalities. JAMA 2002;287:2120–2129.

210 Adolescent Medicine: The Requisites in Pediatrics Wright TC, Jr, Cox JT, Massad LS, et al.: 2001 consensus guide­ lines for the management of women with cervical intraepithelial neoplasia. Am J Obstet Gynecol 2003;189:295–304.

Wright TC, Jr, Schiffman M, Solomon D, et al.: Interim guidance for the use of human papillomavirus DNA testing as an adjunct to cervical cytology for screening. Obstet Gynecol 2004;103: 304–309.

28

C hA p t e r

Introduction Genital Herpes Epidemiology Pathophysiology Evaluation Management

Syphilis Epidemiology Pathophysiology Evaluation Management

Chancroid Epidemiology Pathophysiology Evaluation Management

Introduction Genital ulcer disease (GUD) is a general term that usually refers to lesions caused by specific sexually transmitted infections (STIs). Although GUD is common throughout the world, the specific causes vary widely by geographic region. Genital herpes, syphilis, and chancroid lead the differential diagnosis, but conditions unrelated to STIs should also be considered, such as trauma, StevensJohnson syndrome, Beçhet syndrome, Crohn disease, carcinoma, and bacterial infection. In 25% of cases, no etiology is identified. When the cause is unknown or diagnostic testing is unavailable, the World Health Organization (WHO) recommends the use of epidemiologic data to guide presumptive treatment for the most prevalent organism(s) in the geographic region. Risk factors for GUD include male gender, lack of circumcision, sexual risk behaviors, and infection with human immunodeficiency virus (HIV). The discrepancy

Genital Ulcer Disease: Herpes Simplex Virus, Syphilis, and Chancroid Paula K. Braverman, MD

by gender may reflect the higher rates of hidden, asymptomatic, and undiagnosed GUD in women than men due to anatomy, access to care, and social stigma. The association of GUD with HIV warrants HIV testing at presentation and, if negative, at 3–6 months. This chapter focuses on the three leading causes of GUD in the United States: genital herpes, syphilis, and chancroid.

Genital Herpes Epidemiology Genital herpes is caused by herpes simplex virus (HSV) Type 1 (HSV-1) and Type 2 (HSV-2). The most common cause of the first symptomatic episode of genital herpes among adults is HSV-2 in the United States and HSV-1 in the United Kingdom. An estimated 45 million people in the United States have genital infections with HSV-1 and/ or HSV-2. Annual visits to physician offices in the United States for first episodes of genital herpes have increased 14-fold in 40 years, from less than 19,000 to more than 269,000 (Figure 28-1). HSV-1 and HSV-2 both can infect the oral and/or genital areas. HSV-1 can be transmitted through sexual or nonsexual contact and is the most common cause of oral herpes. HSV-2 is almost always transmitted through sexual contact, regardless of site, and accounts for at least 70% of genital herpes in the United States. Among individuals aged 12–25 years, seropositivity rates are 30–70% for HSV-1 antibody and 10–30% for HSV-2 antibody. HSV-1 seropositivity increases from 44% in individuals aged 12–19 years to 56% in those aged 20–29 years to 90% in those aged 60–69 years. Factors associated with HSV-1 seropositivity include female gender, Hispanic ethnicity, black race, poverty, crowded living conditions, and HSV-2 seropositivity. Genital infection with HSV-1 is 211

212 Adolescent Medicine: The Requisites in Pediatrics

Visits (in thousands)

300 240 180 120 60 0 1966

69

72

75

78

81

84

87

90

93

96

99

2002

Figure 28-1 Initial visits to physicians’ offices for genital herpes, United States, 1966–2004. From: Centers for Disease Control and Prevention: Sexually Transmitted Disease Surveillance, 2004. Atlanta, GA, U.S. Department of Health and Human Services, September, 2005, Figure 39.

a­ ssociated with receptive oral sex, and the proportion of genital herpes cases caused by HSV-1 appears to be increasing over time. Oral HSV-1 infection appears to protect against genital HSV-1 infection and to attenuate the symptoms of genital HSV-2 infection. In contrast to the significant rates of HSV-1 seropositivity among prepubertal children, HSV-2 seropositivity is unusual until adolescence. The prevalence of HSV-2 seropositivity then increases quickly, from 6% among individuals aged 12–19 years to 17% among those aged 20–29 years. Unlike the continued increase in HSV-1 with age, HSV-2 seropositivity reaches a plateau of 24–28% by age 30 years. Factors associated with HSV-2 seropositivity include female gender, Hispanic ethnicity, black race, low socioeconomic status, increased number of lifetime sexual partners, history of other STIs, and cocaine use. HSV-2 transmission is more efficient from male to female than the reverse. Among couples who are discordant for infection, the rate of transmission is approximately 12% per year. Viral shedding and transmission can occur at any time but are most common during symptomatic outbreaks. Although only 10% of seropositive individuals report past symptoms, studies suggest that recall increases significantly following patient education about the clinical manifestation of genital herpes.

Pathophysiology Acquisition of HSV is thought to require direct contact of the mucosa or broken skin with infected secretions. In the active state, the virus replicates in the epidermis and dermis, causing local inflammation and cellular destruction. The virus can spread through the lymphatic system to regional lymph nodes, travel along peripheral axons to sensory nerve root ganglia, and replicate within neural tissue. Local inoculation can also spread the virus beyond the primary site of infection. In the case of HSV-1, the

virus can travel along neurons to the brain, causing encephalitis. Immunocompetent hosts with intact immune systems usually can control the infection and the lesions heal. After the initial infection, HSV resides in a latent phase within the nerve root ganglion until there is a stimulus for reactivation, such as ultraviolet light, local trauma, fever, or immunosuppression. Reactivation severity correlates with the quantity of replicating virus and the immunologic status of the host. Although humeral immu­ nity plays a role in containing HSV infection, cell­mediated immunity appears to be the most important mechanism. Genital HSV infections are categorized according to the presence or absence of pre-existing, type-specific, serum antibodies. Primary infection occurs in the absence of antibodies to either HSV-1 or HSV-2. Non-­primary infection occurs in the absence of antibodies to the current HSV type and the presence of antibodies to the other HSV type (e.g., first HSV-2 infection in an individual with preexisting antibodies to HSV-1). Recurrent infection (i.e., reactivation) occurs in the presence of antibodies to the current HSV type. Primary genital herpes is characterized by painful skin and/or mucosal lesions accompanied by systemic symptoms (e.g., fever, headache, mylagias, and malaise) in 40% of males and 70% of females. The lesions begin as papules and develop into clustered pustules or vesicles on an erythematous base. The pain begins within several days of appearance, as the lesions become ulcers with serous drainage. Up to 95% of males and 99% of females with primary genital HSV infection have these painful lesions, which persist with viral shedding for a mean of 11 days in males and 12 days in females. Mucosal re-epithelialization and nonmucosal crusting begins 4–15 days after appearance of the lesions, with complete healing within 17 days in males and 20 days in females. Systemic symptoms tend



Genital Ulcer Disease: Herpes Simplex Virus, Syphilis, and Chancroid 213

to be most severe during the first week of illness but can persist with regional lymphadenopathy for up to 3 weeks. Other symptoms that can accompany primary HSV infection include dysuria, urinary urgency, and urethral discharge in males. Superinfection of ulcerated lesions can occur in females, and proctitis with rectal pain, bloody or mucoid discharge, tenesmus, and constipation can occur in males and females. HSV is the most common cause of nongonococcal proctitis in males. In contrast to gonococcal proctitis, HSV proctitis often presents as a sacral neuropathy with urinary retention, constipation, and perineal dysesthesia. Proctitis may be found in women and heterosexual men who deny anal intercourse and can be associated with perianal lesions. Extragential manifestations of primary genital herpes include pharyngitis, other skin lesions, and central nervous system (CNS) complications. Pharyngitis, which is associated with oral–genital exposure, can manifest as mild erythema to diffuse ulceration with cervical lymphadenopathy and may be associated with tender cervical nodes. Skin lesions can occur in nongenital locations such as the buttock, groin, thigh, and finger and are usually spread by autoinoculation. CNS complications include aseptic meningitis, transverse myelitis, sacral radiculopathy, and encephalitis. The stiff neck, headache, and photophobia of aseptic meningitis usually begin 3–12 days after the onset of genital lesions and resolve within 1 week. Encephalitis is more likely to be associated with HSV-1 than HSV-2 infection. HSV does not usually disseminate in immunocompetent patients, but maternal genital herpes at the time of vaginal delivery does pose a significant risk to the infant. Patients with severe atopic dermatitis and other generalized skin disorders are also at risk of dissemination. Recurrent genital herpes outbreaks are usually shorter, milder, and more localized than the primary outbreak. Prodromal symptoms are common and include pain in the buttocks or legs for hours to days before the appearance of the skin lesions, which tend to be unilateral. Viral shedding lasts approximately 4 days, crusting begins within 4–5 days, and re-epithelialization is completed within 6–10 days. Recurrences tend to be more severe in females than males. The vaginal ulcerations of recurrent HSV may be confused with trauma or vaginitis because of their often linear appearance. Recurrences affect 60–90% of individuals within 1–2 years of the primary HSV-2 outbreak, with a median of five recurrences in males and four in females during this time period. Those with longer primary episodes tend to have more recurrences, possibly because more ganglionic cells are infected. Viral shedding occurs in up to one-half of subclinical HSV reactivation episodes, with the highest rates of these episodes in the 6 months following primary infection. Asymptomatic shedding can come from small lesions of the cervix, vulva, urethra,

penis, and anus. Over time, the duration of subclinical shedding decreases. Immunocompromise and pregnancy are associated with more severe clinical outbreaks. Immunocom­ promised patients have clinical infections that persist for longer periods of time, are slower to respond to antiviral therapy, and are associated with prolonged shedding of virus.The major concern with HSV infection during pregnancy is transmission to the neonate during delivery. The risk of transmission is 50% for primary HSV-2 without prior HSV-1, 20% for primary HSV-2 with prior HSV-1, and < 1% for recurrent HSV-2, as maternal HSV-2 ­antibodies appear to protect the infant.

Evaluation HSV culture is currently considered the gold standard for confirmation of suspected genital herpes. Its sensitivity depends on the type of lesion from which the specimen is collected. HSV culture is 90–94% sensitive for new vesicular lesions, 70% for ulcers, and 20–30% for crusted lesions. Most culture results are available in 1–4 days, and the viral type can be determined utilizing immunofluorescent techniques. Because a negative culture does not rule out HSV infection, repeat cultures should be performed during subsequent episodes to increase detection rates. HSV is part of a promising polymerase chain reaction (PCR) multiplex test that is not yet commercially available for clinical use. The test uses a specimen collected from a lesion and detects syphilis and chancroid as well as HSV. HSV antigen can also be detected by direct immunofluorescence and immunoperoxidase staining, but their sensitivities are lower at 70–90%. Cytologic examination with Tzanck preparation for multinucleated giant cells and Pap smear are not considered reliable. Serologic testing is not routinely used to confirm genital herpes because seroconversion in primary infection can take up to 3 weeks and recurrent infection may not produce a rise in titer. Newer serologic assays, which are glycoprotein G (gG)-based type-specific have specificities of greater than 96% and sensitivities of 80–98%. Despite these improvements, these serologic tests, which are based in enzyme-linked immunosorbent assay (ELISA) and immunoblot assays, should be utilized cautiously because they can give both false-negative and false-positive results. Serologic tests are most useful for diagnosing unrecognized infection and to confirm a clinical diagnosis in the face of a negative culture. Although finding HSV-2 usually indicates an STI, these tests do not help distinguish modes of transmission for HSV-1 infection. There are also suggestions in the literature that screening pregnant women may identify individuals who are seronegative in the face of a seropositive partner. This would help determine the risk for acquisition

214 Adolescent Medicine: The Requisites in Pediatrics

and transmission to the neonate and allow better counseling on ­prevention.

Management All patients with genital herpes should be advised to inform sexual partners and to avoid sexual contact during the prodromal and active phases of infection. Asymptomatic shedding does occur, and it is important for partners to understand the ongoing risk of ­transmission. Systemic antiviral therapy with acyclovir, valacyclovir, or famciclovir is recommended for primary and recurrent genital herpes, although the dosing schedules vary (Table 28-1). HSV-infected cells selectively phosphorylate these antiviral medications, which are incorporated into the DNA of the virus and lead to chain termination. Treatment of an acute episode decreases symptom duration, symptom severity, viral shedding, and new lesion formation. It should be started when active lesions are present

Table 28-1 CDC Treatment Guidelines for Genital Herpes Simplex Virus One of the Following Regimens

First clinical episode

Drug

Dose

Acyclovir

400 mg orally three times a day × 7–10 days 200 mg orally five times a day × 7–10 days 250 mg orally three times a day × 7–10 days 1 g orally twice a day × 7–10 days

Acyclovir Famciclovir Valacyclovir Episodic therapy for recurrent episodes

Acyclovir Acyclovir Acyclovir Famciclovir Famciclovir Valacyclovir Valacyclovir

Suppressive therapy for recurrent episodes

Acyclovir Famciclovir Valacyclovir Valacyclovir

400 mg orally three times a day × 5 days 800 mg orally twice a day × 5 days 800 mg orally three times a day × 2 days 125 mg orally twice a day × 5 days 1 g orally twice a day × 1 day 500 mg orally twice a day for 3 days 1 g orally once a day × 5 days 400 mg orally twice a day 250 mg orally twice a day 500 mg orally once a day 1 g orally once a day for 10 or more recurrences per year

From: Centers for Disease Control and Prevention: Sexually transmitted diseases treatment guidelines 2006. MMWR 2006;55(RR-11).

and preferably within 1 week of lesion onset in primary infection and within 1 day of lesion onset in recurrent infection. Symptomatic improvement usually begins within 48 hours, but the medication does not decrease the likelihood of recurrence once it is discontinued. Suppressive therapy can reduce recurrent episodes by 70–80% and is recommended for individuals with six or more recurrences yearly. Valacyclovir at a higher dose (i.e., 1 g daily) may be needed for individuals with 10 or more recurrences per year. Because recurrences tend to decrease in frequency over time regardless of treatment, a trial off suppressive therapy should be considered at 1 year. Patients should understand that suppressive therapy does not eliminate viral shedding and that ­transmission to sexual partners may still occur. Resistant strains of HSV have been identified in immunocompromised patients following prolonged or frequent antiviral therapy. In these cases, foscarnet may be given intravenously until there is clinical resolution. Acyclovir is recommended by the Centers for Disease Control and Prevention (CDC) for pregnant women with primary genital herpes, a severe recurrence, and frequent recurrences. Obstetrical management guidelines call for cesarean section when active lesions or prodromal symptoms are present at the time of delivery. Although there have been studies evaluating the use of antivirals late in the third trimester and through delivery, there is no universal recommendation for their use in patients with recurrent episodes. New HSV research developments include the use of topical microbicides to prevent HSV transmission and a prophylactic vaccine.

Syphilis Epidemiology In 1999, the CDC launched a National Plan to Eliminate Syphilis from the U.S. The rates of primary and secondary syphilis had been declining since the early 1990s, and the 2.1 cases per 100,000 population in the year 2000 was the lowest rate recorded in 60 years. Between 1992 and 2004, racial discrepancy in the rates of syphilis declined from a black:white ratio of 63:1 to 5.6:1; rates in the southern states decreased from 22.9 to 3.6 per 100,000; and the rates of primary and secondary syphilis among women, as well as congenital syphilis, declined significantly. Between 2003 and 2004, latent syphilis declined 5–7%, rates in women did not change, and rates of both primary and secondary syphilis among men increased (Figure 28-2). Currently, the highest rates of syphilis are in women aged 20–24 years and men aged 35–39 years. In the year 2004, 41% of all U.S. cases of primary and secondary syphilis were among blacks, 48% of cases were in the southern states, and 21% of all U.S. counties accounted

Genital Ulcer Disease: Herpes Simplex Virus, Syphilis, and Chancroid 215



Rate (per 100,000 population)

25 P&S Syphilis 2010 Target

25 15 10 5 0 1970

73

76

79

82

85

88

91

94

97

2000

03

Figure 28-2 Trends in rates of primary and secondary syphilis in the United States, 1970–2004. From: Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance, 2004. Atlanta, GA, U.S. Department of Health and Human Services, September, 2005, Figure 26.

for 100% of cases. Among individuals aged 15–19 and 20–24 years, the rates of syphilis were 1.7 and 5.0 per 100,000 population, respectively. Syphilis is six times more common in men who have sex with men (MSM) compared with men who only have sex with women. Contributing factors include nonuse of condoms, anonymous partners, HIV infection, and methamphetamine use. Oral–genital sex was the only sexual contact reported by one-fifth of men who were newly infected with syphilis.

Pathophysiology Treponema pallidum enters through breaks in the skin, attaching to and multiplying within host cells at the site of inoculation. Lymphatic and circulatory dissemination occurs within hours of infection and, even in this primary stage of infection, there is evidence of meningeal involvement. The primary, secondary, latent, and tertiary stages of syphilis are described below. Primary syphilis is characterized by a chancre at the site of inoculation that appears 9–90 days (average 3 weeks) after exposure and resolves within several weeks without treatment. It begins as a papule that evolves into a sharply demarcated, indurated ulcer. Although usually painless and firm-based, it can be tender and purulent, particularly when coinfected with HSV or Hemophilus ducreyi. Nonsuppurative, painless, firm, bilateral inguinal lymphadenopathy may accompany the ulcer. The chancre is usually located on the coronal sulcus, glans, prepuce, or penile shaft in men and the labia or vagina in women. However, it can appear wherever abraded skin is exposed to infected secretions. Secondary syphilis develops within a few weeks to months of the primary lesion and is characterized by circulating immune complex; a diffuse, nonpruritic,

maculopapular rash involving the face, trunk, genitalia, palms, soles, and mucous membranes; headache; sore throat; fever; myalgias; malaise; and generalized lymphadenopathy. Less common manifestations include alopecia, arthritis, bursitis, osteitis, gastritis, hepatitis, meningitis, cranial nerve palsies, glomerulonephritis, iritis, uveitis, and retinitis. Secondary syphilis can also involve the formation of grayish skin masses with mucoid secretions that contain spirochetes, usually found on genitalia or the mouth. The lesions resolve in 2–10 weeks without treatment but in 25% of cases relapse within 1 year. Latent syphilis can persist indefinitely. It is associated with seropositivity but no clinical manifestations of disease. Early latent syphilis is defined as less than 1 year and late latent syphilis as more than 1 year since ­infection. Tertiary syphilis refers to diverse clinical manifestations, one or more of which appear in 25–40% of untreated individuals one to 30 years after initial infection. The most common tertiary presentations are gummatous syphilis, cardiovascular syphilis, and late neurosyphilis. Gummas are granulomatous, hypersensitivity reactions to the spirochete that begin as nodules and can progress to ulceration, atrophic scar formation, and fatal tissue destruction. Skin and bones are the most common sites of gumma formation, but nearly any organ can be involved. Cardiovascular syphilis includes obliterative end-arteritis and aortitis, which can lead to aortic aneurysm and aortic valve insufficiency. Tertiary neurosyphilis involves parenchymatous disease of the brain and spinal cord 15–20 years primary infection, with progressive mental illness, dementia, paresis, and tabes dorsalis. It is important to recognize that other CNS manifestations of syphilis may appear in the primary and secondary stages of disease. For example, asymptomatic meningitis (i.e., CSF abnormalities) can occur with primary infection and usually resolves spontaneously.

216 Adolescent Medicine: The Requisites in Pediatrics

Neurosyphilis is a particular concern in HIV-infected individuals who appear to clear CSF abnormalities more slowly and are at risk for treatment failure and relapse. It is hypothesized that HIV impairs the immunologic clearance of the organism and that an intact immune system is needed, along with antibiotics, to eradicate the ­organism from the CNS.

Evaluation T. pallidum can be identified by darkfield examination of lesion exudate or lymph node aspirate, direct fluorescent antibody testing of biopsy specimens, and PCR. However, darkfield examination is time-intensive and requires training and experience; biopsy generally is not clinically necessary; and PCR for T. pallidum is not commercially available. Most diagnoses of syphilis therefore are established by a combination of nontreponemal and ­treponemal serologic tests. The nontreponemal tests are performed as the initial screen and include the Venereal Disease Research Laboratory (VDRL) and Rapid Plasma Reagin (RPR). The results are reported as quantitative antibody titers, which generally reflect disease activity. Titers are lower in primary than secondary syphilis and usually become undetectable following treatment. Some treated individuals, however, continue to have a low titer (referred to as a “serofast reaction”). The false-positive rate of 1–2% is associated with intravenous drug use, hepatitis, pregnancy, connective tissue disease, mononucleosis, other spirochetal infections, and malignancy. False-negative results occur when the test is performed too early in the course of the illness or when a blocking antibody prevents an accurate reading. Patients who are HIV-infected usually have accurate serologic test results. Because of the possibility of a false positive, the nontreponemal test is followed-up and confirmed with a treponemal test. The commonly used tests include the fluorescent treponemal antibody absorbed (FTA-ABS) and the microhemaglutination assay (MHA-TP). The diagnosis of syphilis can be made when a positive nontreponemal test is confirmed by a treponemal test. It is important to note that treponemal tests are not always positive and in fact are negative in 10% of cases of primary syphilis. The treponemal test is almost always positive in the secondary stage of this illness. Once positive, treponemal tests usually stay positive for life and are indicative of past or present infection. However, some individuals do revert to a negative treponemal test when treated early in the course of the disease. If a patient is presenting in the latent stage, it is important to determine whether it is early latent or late latent disease because therapy is different for each. If the timing of the history of a chancre or rash is not clear, it is better to err on the side of classifying the illness as late latent disease.

Patients with neurosyphilis have CSF abnormalities including elevated protein, mild leukocytosis of > 5 white blood cells (WBCs)/mm3, and/or a reactive VDRL-CSF. A positive VDRL-CSF confirms the diagnosis of neurosyphilis, but up to 70% of individuals with neurosyphilis have a negative VDRL-CSF. In addition, patients with HIV infection may have mild CSF pleocytosis on the basis of HIV, which confounds the diagnosis of neurosyphilis. False-positive VDRL-CSF can occur with blood contamination of the CSF. Some authors recommend a CSF FTAABS, which is less specific but more sensitive than the VDRL-CSF. A negative CSF FTA-ABS is believed to effectively exclude the diagnosis of neurosyphilis. Lumbar puncture (LP) for CSF evaluation should be performed in any patient with syphilis who has evidence of neurologic, ophthalmologic, cardiovascular, or gummatous disease, regardless of past treatment history. LP should be performed in any HIV-infected patient with untreated syphilis of unknown duration or in the late latent stage, regardless of clinical manifestations. LP is not recommended in HIV-negative patients with primary and secondary syphilis since prompt treatment has been shown to prevent future neurologic disease.

Management CDC treatment recommendations for syphilis depend on the stage of illness (Table 28-2). If the stage is unknown, the guidelines for late latent syphilis should be applied. The Jarisch-Herxheimer reaction can occur within 24 hours of treatment; is characterized by headache, myalgia, and fever; is more common in early than later stages of syphilis; and is associated with premature labor and fetal distress. The drug of choice for the treatment of syphilis is penicillin G. Skin testing and desensitization are recommended for patients with penicillin allergy. Doxycycline and tetracycline are alternatives, but their use is limited by multiple doses daily, a 14-day course for primary and secondary infections, and a 28-day course for latent infections. Although some studies have demonstrated the efficacy for azithromycin administered as a single 2-g dose to patients with early and early latent syphilis, there have been reports of macrolide-resistant strains and treatment failures in Seattle, Baltimore, San Francisco, and Ireland. Ceftriaxone is listed as an alternative in the CDC guidelines for all stages, but optimal dosing and duration are not well defined. All patients who are treated for syphilis should be screened for HIV at baseline and, if negative, at 3 months. A four-fold decrease in the titer of the same nontreponemal test should be demonstrated to document the adequacy of treatment. Titers should be obtained at baseline, 6, and 12 months for primary and secondary syphilis; and at baseline, 6, 12, and 24 months for latent syphilis. If

Genital Ulcer Disease: Herpes Simplex Virus, Syphilis, and Chancroid 217



Table 28-2  CDC Treatment Guidelines for Syphilis One of the Following Regimens Drug

Dose

Primary and secondary syphilis

Benzathine penicillin G

2.4 million units IM × one dose

Early latent syphilis

Benzathine penicillin G

2.4 million units IM x one dose

Late latent syphilis

Benzathine penicillin G

2.4 million units IM × 3 doses each 1 week apart

Tertiary syphilis

Benzathine penicillin G

2.4 million units IM × 3 doses each 1 week apart

Neurosyphilis

Aqueous crystalline penicillin G

3–4 million units IV every 4 hours or by continuous infusion × 10–14 days, total daily dose of 18–24 million units

Procaine penicillin plus Probenicid

2.4 million units IM once a day × 10–14 days 500 mg orally four times a day × 10–14 days

From: Centers for Disease Control and Prevention: Sexually transmitted diseases treatment guidelines 2006. MMWR 2006;55(RR-11).

the titer does not fall at least four-fold or if signs and symptoms recur after treatment, HIV testing should be repeated. HIV-infected patients with syphilis should have titers repeated at 3-month intervals to assure the adequacy of treatment. Follow-up of neurosyphilis involves examination of the CSF every 6 months until the cell count normalizes. Retreatment of neurosyphilis should be considered if the cell count in the CSF does not decrease in 6 months or normalize in 2 years.

Chancroid Epidemiology The WHO estimates that there are 6 million cases of chancroid worldwide and that up to one-half of all cases of

GUD in Asia, Africa, and the Caribbean are due to chancroid. However, diagnostic testing for H. ducreyi is unavailable in many resource-poor countries, and access to testing is limited even in countries such as the United States. As shown in Figure 28-3, reported cases of chancroid in the United States have fallen dramatically over the past two decades. During the mid-1990s, HSV and syphilis were found in GUD cases from 10 U.S. cities participating in a surveillance study, whereas chancroid was found in cases from only two cities. By 2004, no state reported more than four cases of chancroid and, of the 30 total cases nationwide, 20 were in men.

Pathophysiology H. ducreyi infects the skin or mucosa through microabrasions during sexual intercourse. Only some strains of the organism are virulent, and those strains are resistant to both cell-mediated and complement-mediated host responses. Polymorphonuclear lymphocytes and macrophages infiltrate the epidermis and dermis in response to the infection, forming a papule within 3–10 days. The papule progresses to a pustule more commonly in males than females, and the pustule progresses to an ulcer within 2–3 days. The typical ulcer of chancroid is painful, well circumscribed, and nonindurated. It has ragged, undermined edges; a friable, granulomatous base; and a yellow or gray purulent exudate. One ulcer is seen in half of males with chancroid, whereas several discrete lesions are common in females. “Kissing ulcers” can occur from autoinoculation. Without treatment, the ulcers can last weeks to months and are susceptible to superinfection by other bacteria. Ulcers in males are commonly located on the prepuce, frenulum, and coronal sulcus, although they can be found on the glans, meatus, and penile shaft. Edema of the prepuce and phimosis are potential complications, and cases of acute purulent urethritis have been also been reported. In females, lesions are most commonly seen on the labia majora, posterior fourchette, labia minora, periurethral area, and clitoris. There can also be vaginal, cervical, and

Figure 28-3 Reported cases of chancroid, United States, 1981–2004. From: Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance, 2004. Atlanta, GA, U.S. Department of Health and Human Services, September, 2005, Figure 38.

Cases (in thousands)

5 4 3 2 1 0 1981 1983 1985 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005

218 Adolescent Medicine: The Requisites in Pediatrics

perianal ulcers. Because of the location of lesions in women, the presenting complaint may be dysuria, painful defecation, dyspareunia, or vaginal discharge. Tender regional lymphadenitis follows the ulcer stage in up to 50% of individuals. This represents an inflammatory response without a significant numbers of organisms. The lymphadenopathy is usually unilateral, matted, and erythematous. Nodes that fill with thick viscous pus constitute a bubo, which can rupture spontaneously and/ or form an inguinal abscess, large ulcer, or draining sinus. Surgical drainage is indicated if the bubo is large and intact. H. ducreyi does not appear to disseminate or become invasive even in immunocompromised individuals. However, immunocompromise is associated with prolonged incubation and more severe regional disease.

Evaluation The diagnosis of chancroid is made by demonstrating H. ducreyi and excluding other causes of GUD, which in the United States means primarily HSV and syphilis. Microscopic examination of a gram-stained preparation of material from an ulcer or bubo may reveal H. ducreyi, but the sensitivity and specificity are low because of the many other microbes that colonize the lesion. Culture of H. ducreyi from a calcium alginate or cotton swab of the ulcer base carries a sensitivity of 65–70% when one medium is used and 80–90% when two are used. Ideally, the specimen should be cultured on collection because transport media are generally unavailable. Alternatively, the swab can be stored at 4 oC. PCR is the most sensitive test for H. ducreyi, at 90%, but it is not available for commercial use. Serologic tests such as enzyme immunoassay, dot immunobinding, agglutination, complement fixation, and fluorescent antibody assay do not differentiate current from past infections and therefore are of limited use for immediate diagnosis. Rapid diagnostic testing of swab material, using indirect immunofluorescence of monoclonal antibodies directed against outer membrane proteins, appears to be more sensitive than culture and may prove particularly useful in ­resource-poor countries.

Management Presumptive treatment for clinically suspected chancroid should be initiated if specific laboratory testing is unavailable and syphilis and HSV are excluded. CDC­recommended treatment options are outlined in Table 28-3 and include azithromycin, ceftriaxone, ciprofloxacin, or erythromycin. Ciprofloxacin cannot be used in pregnancy, and resistance to ciprofloxacin and erythromycin has been reported worldwide. Treatment

Table 28-3  CDC Treatment Guidelines for Chancroid One of the Following Regimens Drug

Dose

Azithromycin Ceftriaxone Ciprofloxacin Erythromycin

1 g orally × one dose 250 mg IM × one dose 500 mg orally two times a day × 3 days 500 mg orally three time a day × 7 days

From: Centers for Disease Control and Prevention: Sexually transmitted diseases treatment guidelines 2006. MMWR 2006;55(RR-11).

f­ ailures with ceftriaxone have also been reported in Africa. Lack of circumcision and HIV infection are associated with poorer response to treatment. Patients who are HIVinfected should be closely monitored and may need longer courses of therapy with ciprofloxacin or erythromycin. All patients should be tested for HIV at the time of diagnosis and retested for syphilis and HIV in 3 months if the initial tests are negative. Symptomatic improvement usually occurs in 3 days, with objective improvement in 7 days, complete ulcer healing in 2 weeks, and resolution of lymphadenopathy in 3 weeks. Buboes may require incision and drainage, and larger ulcers may require more than 2 weeks of therapy for complete healing. Treatment failure should raise questions about the diagnosis as well as prompt repeat HIV testing.



Major Points

b

HSV is the most common cause of GUD in the United States. l GUD is associated with increased susceptibility to and increased transmission of HIV, and all patients with GUD should undergo HIV testing. l Immunocompromised patients are more likely to present with complications of GUD, may have a prolonged clinical course, and may require longer therapeutic regimens. l Muliplex PCR is the most sensitive testing method for HSV, syphilis, and chancroid but is not yet available for commercial use. l Condoms decrease, but do not completely prevent, the transmission of organisms responsible for GUD. l



Genital Ulcer Disease: Herpes Simplex Virus, Syphilis, and Chancroid 219

Bibliography Auslander BA, Biro FM, Rosenthal SL: Genital herpes in adolescents. Semin Pediatr Infect Dis 2005;16:24–30. Chesson HW, Heffelfinger JD, Voigt RF, et al.: Estimates of primary and secondary syphilis rates in persons with HIV in the United States, 2002. Sex Transm Infect 2005;32:265–269. Geretti AM, Brown DW: National survey of diagnostic services for genital herpes. Sex Transm Infect 2005;81:316–317. Goh BT: Syphilis in adults. Sex Transm Dis 2005;81:448–452. Holmes KK: Azithromycin versus penicillin G benzathin for early syphilis. N Engl J Med 2005;353:1291–1293. Hook EW, Peeling RW: Syphilis control—A continuing chall­­­ enge. N Engl J Med 2004;351:122–124. Lewis DA: Diagnostic tests for chancroid. Sex Transm Inf 2000;76:137–141.

Lukehart SA, Godornes C, Molini B, et al.: Macrolide resistance to Treponema pallidum in the United States and Ireland. N Engl J Med 2004;351:154–158. Riedner G, Rusizoka M, Todd J, et al.: Single-dose azithromycin versus penicillin G benzathine for the treatment of early syphilis. N Engl J Med 2005;353:1236–1244. Roberts CM: Genital herpes in young adults: Changing sexual behaviours, epidemiology and management. Herpes 2005;12:10–14. Rupp R, Rosenthal SL, Stanberry LR: Pediatrics and herpes simplex virus vaccines. Semin Pediatr Infect Dis 2005;16: 31–37. Wald A, Langenberg A, Krantz E, et al.: The relationship between condom use and herpes simplex virus acquisition. Ann Intern Med 2005;143:707–713.

29

C h A p t e r

Introduction Definitions Epidemiology Pathophysiology HIV Life Cycle Acute HIV Infection

Evaluation HIV Testing Acute HIV Infection Newly Diagnosed HIV Infection Potential Exposure to HIV

Management Acute HIV Infection Health Maintenance for HIV-Infected Youth Antiretroviral Therapy Opportunistic Infections

Human Immunodeficiency Virus Marina Catallozzi, MD

In the United States, the face of the HIV/AIDS epidemic has changed dramatically. Adolescents and young adults less than 25 years of age now account for half the new HIV infections reported annually to the CDC and for most perinatally acquired infections. As a result, strategies to prevent new infection and manage the long-term effects of past infection have focused increasingly on the second and third decades of life. The objectives of this chapter are to review the epidemiology, pathophysiology, evaluation, and management of HIV/AIDS in youth who acquire the infection perinatally or behaviorally. Although many clinicians who care for adolescents will refer HIV-infected patients, all should be knowledgeable about preventive counseling, postexposure prophylaxis, HIV screening, the acute seroconversion syndrome, and when to begin therapy.

Outcome

Definitions Introduction The human immunodeficiency virus (HIV) was identified in 1983, 2 years after the first five cases of the acquired immunodeficiency syndrome (AIDS) were reported by the Centers for Disease Control and Prevention (CDC). The ensuing years witnessed rapid advances in the prevention and management of HIV/AIDS and dramatic shifts in its epidemiology. In developed countries, the availability of effective antiretroviral therapy reduced perinatal transmission to 1–3%; prolonged survival; increased resistance to 15% of circulating strains; and introduced a set of common side effects called body-fat abnormalities. In developing countries, however, less than 20% of those needing antiretroviral therapy receive it and interventions to reduce behavioral risk have had limited impact. As a result, the developing world accounts for 95% of AIDS-related deaths and new HIV infections. 220

Acquired immunodeficiency syndrome (AIDS): The advanced stages of HIV infection defined by the CDC as a CD4 T-cell count 1,000 copies/ml and encourage the consideration of resistance testing in all patients who are new to care, regardless of viral load or treatment plan. The DHHS Panel emphasizes that recommendations pertaining to HIV care change frequently and encourages health care providers to check the AIDSinfo web site frequently (http://AIDSinfo.nih.gov).

Potential Exposure to HIV Exposure to HIV during adolescence can occur through sexual contact, the sharing of drug-use equipment, or contact with blood and/or genital secretions. In some cases the contact is known to be infected with HIV, but in

Box 29-2  Baseline Laboratory Evaluation for Patients New to HIV Care l l l l

l l

l l

l l l l

l

Confirmation that HIV antibody test is positive CD4 T cell count Plasma HIV RNA measurement of viral load Genotypic resistance testing if HIV RNA > 1,000 copies/ml. Consider resistance testing in all patients new to care. Complete blood count Serum electrolytes, blood urea nitrogen, creatinine, liver function studies, and lipid panel Urinalysis Tuberculin skin test, unless there is a known history of prior tuberculosis or positive skin test Toxoplasma gondii IgG level Hepatitis A, B, and C serologies Rapid plasma reagin (RPR) Testing for Chlamydia trachomatis and Neisseria gonorrhea Papanicolaou testing in females

Adapted From: Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Department of Health and Human Services. October 10, 2006; 1–113. Available at http://www.aidsinfo.nih.gov/ContentFiles/ AdultandAdolescentsGL.pdf.

most cases the HIV status of the contact is unknown. Adolescents who are within 72 hours of known or highrisk exposure should be offered prophylaxis with a 28-day course of combination antiretroviral therapy. Prior to initiating the therapy, the following laboratory studies should be performed: CBC, liver function studies, HIV antibody testing, RPR, and hepatitis B and C serologies. A full history should be obtained to avoid the use of medications that interact with antiretroviral therapy.

Management Acute HIV Infection The management of acute HIV infection is controversial. Some experts argue that early antiretroviral therapy may limit viral dissemination, enhance HIV-specific immune responses, and decrease symptoms associated with acute seroconversion. However, the evidence supporting these theories is inconclusive. The 2006 DHHS guidelines therefore state that antiretroviral therapy should be optional for adolescents and adults with acute HIV infection or seroconversion within the previous six months. If the decision is to treat, genotypic resistance testing should be performed to help construct the treatment regimen. Patients diagnosed with acute seroconversion syndrome should be counseled immediately about their high infectivity and the importance of safer sex practices.

224 Adolescent Medicine: The Requisites in Pediatrics

Health Maintenance for HIV-Infected Youth Current health care guidelines call for the quarterly monitoring of HIV-specific parameters and at least annual monito­ ring of general health issues. The HIV-specific parameters include CD4 T-cell count, measurement of HIV RNA, and an assessment of adherence to antiretroviral therapy (if applicable). General health issues include an assessment of psychosocial issues such as health insurance, housing, substance use, domestic violence, and ­sexual behaviors. HIV-infected individuals should see a nutritionist at least yearly and a dentist every 6 months. Individuals with CD4 T-cell counts 350, cells/mm3, HIV RNA < 100,000 copies/ml CD4 count > 350, asymptomatic

Initiate Initiate Initiate Initiate Usually initiate May initiate Defer

Adapted From: Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Department of Health and Human Services. October 10, 2006; 1–113. Available at http://www.aidsinfo.nih.gov/ContentFiles/ AdultandAdolescentsGL.pdf.

Table 29-2 categorizes the antiretroviral medications by drug class (i.e., NRTIs, NNRTIs, and PIs) and summarizes the toxicities common to all medications within a class and those specific for a given medication.Table 29-3 Table 29-2 Antiretroviral Medications and Associated Toxicity Drugs by Class

Toxicity

NRTIs

Lactic acidosis, hepatotoxicity, hepatic steatosis, myopathy, lipoatrophy Marrow suppression Pancreatitis

Zidovudine (AZT) Stavudine (D4T) Emtricitabine (FTC) Didanosine (DDI) Abacavir (ABC) Zalcitabine (DDC) Tenofovir (TDF)

Pancreatitis Hypersensitivity Nephrotoxicity

NNRTIs Delaviridine Efavirenz Nevirapine PIs Atazanavir Fosamprenavir Indinavir Lopinavir Nelfinavir Ritonavir Saquinavir

Transient central nervous system effects Stevens-Johnson syndrome, toxic epidermal necrosis, hepatotoxicity Insulin resistance, hyperlipidemia, hepatotoxicity Indirect hyperbilirubinemia, QTc prolongation Sulfa rash Nephrotoxity Gastrointestinal Interacts with many other drugs

NNRTI, Non-nucleoside reverse transcriptase inhibitor; NRTI, Nucleoside reverse transcriptase inhibitor; PI, Protease inhibitor.

Human Immunodeficiency Virus 225



Table 29-3  Antiretroviral Regimens for Initial Therapy NNRTI

PI

Dual-NRTI

Preferred

efavirenz

or

atazanavir + ritonavir; or fosamprenavir + ritonavir; or co-formulated lopinavir/ritonavir

plus

co-formulated tenofovir/emtricitabine; or co-formulated zidovudine/lamivudine

Alternative

nevirapine

or

atazanavir; or fosamprenavir; or fosamprenavir + ritonavir; or co-formulated lopinavir/ritonavir

plus

co-formulated abacavir/lamivudine; or didanosine + (emtricitabine or lamivudine)

NNRTI, Non-nucleoside reverse transcriptase inhibitor; PI, Protease inhibitor; NRTI, Nucleoside reverse transcriptase inhibitor. Adapted From: Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Department of Health and Human Services. October 10, 2006; 1–113. Available at http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentsGL.pdf.

summarizes the components of antiretroviral therapy regimens recommended by the 2006 DHHS Panel for initial treatment. The Panel categorizes each component as preferred or alternative to preferred. A regimen should incl­ude one NNRTI plus two NRTIs or one PI (single or ritinovir-boosted) plus two NRTIs. Combinations to avoid are zidovudine + stavudine because of their antagonistic effects, and stavudine + didanosine because of the high risk of lactic acidosis, hepatotoxicity, myopathy, and lipoatrophy. Failure to respond, toxicity, and intolerance are indications for a change in regimen. Treatment failure is defined as HIV RNA > 400 copies/ml at 24 weeks or > 50 copies/ml at 48 weeks; an increase in CD4 T-cell count of < 50 cells/mm3 at 1 year; or the development of HIV-related disease at 3 months. Poor adherence is not an indication for a change in regimen because of the risk of developing drug resistance, unless it is believed that the new regimen will simplify administration enough to alter adherence. Before changing the regimen, resistance testing of the new regimen should be performed to ensure responsiveness to at least one of its component medications.

Opportunistic Infections Table 29-4 addresses when to institute prophylaxis for opportunistic infections. The most common opportunistic infections in adolescents with HIV are invasive bacterial infections (e.g., sinusitis, pneumonia, bacteremia); Pneumocystis jiroveci (formerly Pneumocystis carinii) pneumonia (PCP); Herpes zoster; esophageal candidiasis; and disseminated Mycobacterium avium complex (MAC). Bacterial Infections: Local resistance patterns to infectious agents, as well as recent prophylaxis or treatment, should be considered when treating bacterial infections. Severe immunocompromise (CD4 T-cell

count < 200 cells/mm3) requires broad-spectrum antibiotics that cover both resistant and nonresistant organisms. Invasive bacterial disease in an HIV-infected patient generally is treated with a broad-spectrum cephalosporin (e.g., ceftriaxone, cefotaxime, or cefuroxime) until an organism is identified. Fever and an indwelling catheter are indications for coverage of both gram-negative and gram-positive organisms, such as with ceftazidime to cover pseudomonas and vancomycin to cover methicillin-resistant Staphylococcus aureus. PCP: Suspicion of PCP should prompt presumptive treatment with trimethoprim/sulfamethoxazole (TMP/ SMX) in the patient without known sulfa hypersensitivity. Treatment should not await confirmation of the diagnosis because clinical deterioration may be rapid, and culture for P. jiroveci of infected secretions collected by bronchoscopic bronchoalveolar lavage remain positive for at least 72 hours after the start of antibiotics. The starting dose for PCP is TMP 15–20 mg/kg body weight/ day and SMX 75–100 mg/kg/day administered intravenously in three to four divided doses. Once the patient has stabilized, the TMP/SMX can be administered orally to complete a 21-day course. Adverse reactions to TMP/ SMX are common in HIV-infected adults and can include Stevens-Johnson ­ syndrome, hematologic abnormalities, and gastrointestinal complaints. Patients with mild skin rashes (not Stevens-Johnson) can be rechallenged with TMP/SMX. Patients with documented or suspected PCP who cannot tolerate TMP/SMX can be treated with pentamidine 4 mg/kg/day, given intravenously over 60–90 minutes until clinical improvement, followed by oral administration to complete a 7- to 10-day course. However, pentamidine should be used cautiously in the setting of renal insufficiency or other nephrotoxic medications. When pentamidine cannot be used, alternative regimens include oral atovaquone (750 mg twice daily);

226 Adolescent Medicine: The Requisites in Pediatrics

Table 29-4  Prophylaxis against Opportunistic Infections Infection

Medication

When to Initiate Prophylaxis

When to Stop Prophylaxis

Pneumocystis jiroveci (formerly Pneumocystis carinii)

TMP/SMX (DS daily, SS daily, DS QOD) Dapsone 100 mg daily Pentimadine (aerosolized) 300 mg monthly Atovoquone 1500 mg daily TMP/SMX (DS daily or SS daily) Dapsone 50 mg daily plus Pyrimethamine 50 mg weekly plus Leucovorin 25 mg weekly Atovaquone with or without Pyrimethamine Azithromycin 1200 mg weekly Clarithromycin 500 mg BID

CD4 T-cell count < 200 (or CD4 T-cell % < 14)

CD4 T-cell count > 200 for > 3 months

CD4 T-cell count < 100 and positive serology to toxoplasma

CD4 T-cell count > 200 for > 3 months CD4 T-cell count > 200 for > 6 months if patient with history of toxoplasmosis and has undergone treatment

CD4 T-cell count < 50

CD4 T-cell count > 100 for > 3 months CD4 T-cell count > 100 for 6 months with a history of disseminated MAC after 12 months of therapy and asymptomatic

Toxoplasma gondii

Mycobacterium avium complex

Mycobacterium tuberculosis

INH 300 mg daily for 9 months

+ PPD > 5 mm in HIV patient (must rule out active disease with CXR)

BID, twice daily; CXR, Chest X-ray; DS, double-strength; INH, isoniazid; MAC, Mycobacterium avium complex; PPD, purified protein derivative; QOD, every other day; SS, single-strength; TMP/SMX,Trimethoprim/sulfamethoxazole.

clindamycin and primaquine (contraindicated in patients with glucose-6-phosphate-dehydrogenase deficiency); trimetrexate glucuronate with leucovorin (folinic acid); or dapsone/trimethoprim. Moderate or severe PCP, defined as an alveolar-arterial gradient >35 mmHg or a partial pressure of arterial ­oxygen < 70 mmHg, benefit from corticosteroids begun within 72 hours of the suspected or confirmed diagnosis. Clinical studies vary in their corticosteroid doses, but most have included tapers that last the duration of antibiotic treatment. Candidiasis: Uncomplicated orpharyngeal candidiasis usually can be treated topically with clotrimazole troches 10 mg orally four to five times daily for 14 days or nystatin suspension four times daily for 14 days. Severe oropharyngeal candidiasis in an HIV-infected patient warrants the consideration of an oral azole instead of topical therapy. Fluconazole given once daily for 7–14 days is generally well tolerated and effective. Alternatives include itraconazole solution, which is better absorbed than the capsular form, and ketoconazole, which is limited in its effectiveness by poor absorption. Prior to the initiation of an azole, liver function studies should be checked and other medications (e.g., antiretrovirals) that utilize the cytochrome P-450 pathway should be noted and monitored.

Varicella-zoster Virus (VZV): The VZV can manifest as chickenpox on primary infection and as herpes zoster syndrome or “shingles” on reactivation of latent VZV infection within the sensory dorsal root ganglia. HIV-infected patients are susceptible to clinically severe primary varicella and subsequent herpes zoster, particularly as the CD4 T-cell count falls below 200 cells/mm3. HIV-infected patients with primary varicella and a primary or recurrent bout of herpes zoster should be treated with acyclovir intravenously or orally, depending on the severity of illness. Of note, the dose of acyclovir requires adjustment in patients with abnormal renal function. Nonoccupational Postexposure Prophylaxis (NPEP): The CDC recommends that NPEP be offered to any individual who presents within 72 hours of ­exposure to a known HIV-infected contact when that expo­ sure is through the vagina, rectum, eye, mouth, other mucous membrane, or nonintact skin and to the contact’s blood, semen, vaginal secretions, rectal secretions, breast milk, or any body fluid that has visible blood. The caveat is that this should be an isolated exposure. This means that NPEP is not indicated for the individual who regularly has unprotected sex with an HIV-infected partner. It would be indicated, however, following

Human Immunodeficiency Virus 227



condom breakage for the couple who regularly has protected sex. A case-by-case decision about NPEP should be made when the contact’s HIV status is unknown. Generally, risk is considered negligible if the contact’s secretions were not visibly contaminated with blood. Even when risk is considered substantial, NPEP is not indicated beyond 72 hours of exposure. Current guidelines recommend NPEP with a threedrug, NNRTI-based or PI-based regimen. The preferred NNRTI regimens are (efavirenz) + (lamivudine or emtricitabine) + (zidovudine or tenofovir). The preferred PIbased regimens are (lopinavir/ritonavir) + (lamivudine or emtricitabine) + (zidovudine). Regardless of the regimen, the baseline laboratory evaluation described above should be performed, along with counseling about medication side effects and signs of seroconversion. Patients should be evaluated for side effects at 48–72 hours after beginning treatment; for toxicity at 2 weeks; and for HIV testing at 6 weeks, 3 months, and 6 months. Secondary Prevention: Education about the secondary prevention of HIV is essential for all HIV-infected individuals, as well as those with suspected acute seroconversion or who are on NPEP. The counseling should include the importance of and strategies for partner disclosure. Some individuals who are reluctant to tell partners alone are able to disclose in the presence of clinicians. Others may rely on anonymous partner notification systems through local departments of health. Issues of patient safety (e.g., domestic violence or partner retaliation) should always be considered prior to disclosure. It is important to review state laws about provider responsibilities with regard to partner notification.

Outcome Outcome data for HIV-infected adolescents are available through a federally funded project entitled Reaching for Excellence in Adolescent Care and Health (REACH). The project was a study of disease progression in individuals infected at ages 12–18 years, primarily through sexual contact. Analysis of the REACH data suggests that infection during adolescence compared with adulthood may be associated with better response to therapy and longer survival. Potential explanations for the findings include the higher thymic reserve of adolescents compared with adults and the lower rates of fat and muscle wasting. However, the relatively short duration of the REACH follow-up and its inherent limitations (e.g., timing of infection) leave many questions unanswered and emphasize the importance of ongoing clinical research with HIV-infected adolescents.

 l

l

l

l

l

l

Major Points

b

Adolescents represent half of new HIV infections in the United States. The risk of infection is particularly high for minority adolescents and young men who have sex with men (YMSM). Routine HIV testing and education are critical components of primary and preventive care for adolescent-aged patients. The acute HIV seroconversion syndrome is commonly missed and should be included in the differential diagnosis of any adolescent presenting with a mononucleosis-like syndrome and a history of HIV-risk behavior. Adolescents who are within 72 hours of known or high-risk exposure should be offered prophylaxis with a 28-day course of combination antiretroviral therapy. The treatment of HIV infection and opportunistic infections in adolescents with sex maturity ratings (i.e.,Tanner stages) of 3 and greater is the same as that for adults. Dosage adjustments should be made for adolescents with sex maturity ratings of 1 to 2. Appropriate adolescent HIV care utilizes a multidisciplinary care team addressing psychosocial and medical needs and discussing future transition to adult care. Although adherence might not be achieved, engagement in care should be the goal as it sets the groundwork for future care.

Bibliography Berkenbilt G, Sullivan L, Sosman J, et al. Update in HIV care. JGIM 2007;22:253–256. Catallozzi M, Futterman DC: HIV in adolescents. Curr Infect Dis Rep 2005;7:401–405. Centers for Disease Control and Prevention: Antiretroviral Postexposure Prophylaxis After Sexual, Injection-Drug Use, or Other Nonoccupational Exposure to HIV in the United States, (Vol 54). Atlanta, GA, U.S. Department of Health and Human Services, 2005. Centers for Disease Control and Prevention. HIV/AIDS Surveillance Report, 2005. Vol 17, Rev. ed. Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention; 2007. Centers for Disease Control and Prevention. Revised Recommendations for HIV Testing of Adults, Adolescents, and Pregnant Women in Health-Care Settings. MMWR 2006; 55 (No.RR-14). Centers for Diseas Control and Prevention: Treating Opportunistic Infections among HIV-Infected Adults and Adolescents: Recommendations from CDC, The National

228 Adolescent Medicine: The Requisites in Pediatrics Institutes of Health, and the HIV Medicine Association/ Infectious Diseases Society of America (Vol 53). Atlanta, GA, U.S. Department of Health and Human Services, 2005. Centers for Disease Control and Prevention. Youth Risk Behavior Surveillance – Unites States, 2005. Surveillance Summaries, June 9, MMWR 2006; 55 (No. SS-5). D’Angelo LJ, Samples C, Smith Rogers A, et al.: HIV infections and AIDS in adolescents: An update of the position of the Society for Adolescent Medicine.  J Adolesc Health 2005;138:88–91. Ellickson PL, Collins RL, Bogart LM, et al.: Scope of HIV risk and co-occurring psychosocial health problems among young adults: Violence victimization, and substance use. J Adolesc Health 2005;36:401–409. Flynn PM, Rudy BJ, Douglas SD, et al.: Virologic and imm­ unologic outcomes after 24 weeks in HIV type 1-infected adolescents receiving highly active antiretroviral therapy. J Infect Dis 2004;190:271–279.

Grant AM, Jamieson DJ, Elam-Evans LD, et al.: Reasons for testing and clinical and demographic profile of adolescents with non-perinatally acquired HIV infections. Pediatrics 2006;117:468–475. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. Department of Health and Human Services. October 10, 2006; 1–113. Available at http://www. aidsinfo.nih.gov/ContentFiles/AdultandAdolescentsGL.pdf. Pincus JM, Crosby SS, Losina E, et al.: Acute human immunodeficiency virus infection in patients presenting to an urban urgent care center. Clin Infect Dis 2003;37:1699–1704. Thomas CF, Limper AH: Pneumocystic pneumonia. N Engl J Med 2004;350:2487–2498.

30

C h A p t e r

Introduction Definitions Epidemiology Mechanisms of Action Evaluation Medical Conditions Current Medications Menstrual History Social and Sexual History Family History Physical Examination

Contraception Paula J. Adams Hillard, MD

and rates of adolescent sexual activity, pregnancy, and contraceptive use. The mechanisms, contraindications, benefits, risks, and side effects of the specific contraceptive methods available to U.S. adolescents are then discussed. Of note, Tables 30-2 and 30-3 at the end of this chapter provide important information about specific contraceptive methods. Referring to these tables will be helpful as you read through the definitions below.

Definitions

Management

Introduction Contraception is essential for the vast majority of sexually active adolescent females who do not wish to become pregnant. Although adolescent pregnancy remains more prevalent in the United States than other developed countries, the availability of several novel contraceptive delivery systems in the United States accounts for 50–75% of the decline noted in the last 10–15 years. The common factor shared by these transdermal, vaginal, intrauterine, intramuscular, and subcutaneous systems is a longer duration of action compared with the oral contraceptive pill, making successful use more likely. Although condom use probably has had a lesser impact on adolescent pregnancy than the more efficacious hormonal methods, the percentage of sexually active high school students reporting condom use at last intercourse increased 37% over 12 years, reaching 63% in 2003 and remaining stable at that level in 2005. Clinicians must be prepared to counsel adolescents about both the advantages of sexual abstinence and the risks of unprotected sexual intercourse. For those adolescents who are or plan to become sexually active, the provision of confidential and comprehensive reproductive health care is essential. This chapter reviews the trends

Barrier contraception: Blocks sperm transport. Methods such as condoms and diaphragms often are used in conjunction with spermicides. Emergency contraception: Reduces the risk of pregnancy by at least 75% if initiated within 72 hours after unprotected intercourse. There are no medical contraindications to its use except that it is ineffective if taken during an established pregnancy. Estrogens such as ethinyl estradiol are produced synthetically and used with progestins to enhance the contraceptive effect and regulate bleeding. Methods include combination oral contraceptive pills, transdermal patches, and the vaginal ring. Hormonal contraception: Contains estrogens and progestins or progestins alone. Delivery systems for the hormone(s) include oral contraceptive pills, transdermal patches, vaginal rings, intramuscular injections, intrauterine devices, and subcutaneous implants. Menstrual molimina: Uncomfortable symptoms associated with menses that suggest ovulatory cycles (e.g., dysmenorrhea, breast tenderness, bloating, or mood changes). Permanent contraception: Irreversible or permanent male or female sterilization. This option is rarely indicated for adolescents, and clinicians with experience and expertise in its use during adolescence should always be involved in the discussions and decisions. 229

230 Adolescent Medicine: The Requisites in Pediatrics

Progestins or progestogens are produced synthetically and can be used for contraception either alone or with estrogens. Progestin-only methods (e.g., depot medroxyprogesterone acetate, progestin-only pills, and the progestin intrauterine system) prevent pregnancy by suppressing ovulation and altering the endometrium, cervical mucus, and sperm transport. Reversible contraception: Includes hormonal and barrier methods that can be discontinued to allow subsequent pregnancy. Spermicides: Topical formulations that kill sperm. Intravaginal formulations are available as a gel, foam, cream, film, suppository, or tablet. Many condoms also are manufactured with spermicides.

Epidemiology Pregnancy affects one-third of U.S. females by age 20 years, despite a dramatic decline in the rate of teen pregnancy over the last 50 years (Figure 30-1). Most adolescent pregnancies are unintended and abortion rates remain 100 90 80 70 60 50 40 30 20 10 0 1950

1970 1981

1983

1985

1987 1989

high, at 744 per 1000 live births for adolescents age < 15 years and 400 per 1000 for those age 15–19 years. Adolescent pregnancy rates in the United States are two to three times the rates in Canada and Europe and eight times the rates in the Netherlands and Japan, despite similar rates of sexual activity (Figure 30-2). Explanations for the lower rates in these countries compared with the United States include better contraceptive counseling, access, services, and utilization. Healthy People 2010, a government initiative that provides a blueprint of U.S. health priorities, calls for contraceptive use by 100% of teens who are at risk for unintended pregnancy and the delivery of reproductive health education that includes contraception to 90% of all adolescents by age 18 years. The 2002 National Survey of Family Growth (NSFG) indicated that 77% of adolescents had received such education and that 98% of those who reported sexual activity had previously used some method of contraception (Figure 30-3). Condoms are the most frequently used method, reported by 94% at some time in the past, 66% at first intercourse, and by 54% at last intercourse (Figures 30-3 to 30-5). Conversely, more than half of

1991

1993

1995 1997

1999

2001

2003

Figure 30-1 Adolescent pregnancy rates. National Center for Health Statistics: Health, United States, 2004, with Chartbook on Trends in the Health of Americans. Hyattsville, MD, National Center for Health Statistics, 2004, p. 43–44.

90 Births Abortions

80 70 60 50 40 30 20 10

U K an a Au da s Sl tra ov li ak a R ep Ic e C la ze nd ch R N ep or w Sw ay e D den en m a Fr rk an ce Fi nl an Be d lg iu G m re ec e Ita ly S N et pa he in rla nd s Ja pa n C

H

N

U

ni

te

d

St

at e un s ew ga Ze ry al an d

0

Figure 30-2 International birth and abortion rates. Data plotted from: UNICEF Innocenti Research Center: Teenage Births in Rich Nations, Innocenti Report Card 3. Florence, Italy, UNICEF IRC, pp 32.

Contraception 231

0 10 20 30 40 50 60 70 80 90 100 Any method

97.7

Condoms

93.7 61.4

OCs

ECPs

30

9.9

Other

20

8.1

Female condom

1.7

Patch

1.5

7.5

13.1

0

0 10 20 30 40 50 60 70 80 90 100 83.2 70.7 79.9

Any method

38.2 31.3

Condoms

25

OCs

54.3

Depo-Provera) was approved for contraceptive use in 1992 and by 2002 had been used by 20% of sexually active adolescents. Overall, the trends in contraceptive use demonstrate increases for the longer-acting methods that are easier to use. The next cycle of national surveys will provide information about methods such as the intravaginal ring and the levonorgestrel-containing intrauterine system (IUS, Mirena).

42.7

Mechanisms of Action

29.3 20.1

16.8 8.4 3.3

Data from National Survey of Family Growth. Abma JC, Martinez GM, Mosher WD, et al.: Teenagers in the United States: Sexual activity, contraceptive use, and child bearing, 2002. National Center for Health Statistics. Vital Health Stat 23(24), 2004.

34.2

16.8

No method

All other

16.5

Figure 30-5 Contraception use at the time of first intercourse.

a­ dolescents ages 15–19. Data from National Survey of Family Growth. Abma JC, Martinez GM, Mosher WD, et al.: Teenagers in the United States: Sexual activity, contraceptive use, and child bearing, 2002. National Center for Health Statistics. Vital Health Stat 23(24), 2004.

Other hormonal

25.5

10

Figure 30-3 Ever use of contraception by sexually active

Hormonal + condom

66.4

70

40

10.8

Periodic abstinence

80

50

20.7

Injectable

No method Condom Pill Withdrawal Dual methods

90

60

55

Withdrawal

100

2002 1995 1988

9.1 7 1.6 9.6 9.3

Figure 30-4 Contraception at last intercourse—trends. Data from National Survey of Family Growth. Abma JC, Martinez GM, Mosher WD, et al.: Teenagers in the United States: Sexual activity, contraceptive use, and child bearing, 2002. National Center for Health Statistics. Vital Health Stat 23(24), 2004.

adolescents reported that they at some time had relied on withdrawal to protect against pregnancy. Information regarding the use of newer contraceptive options is only partially reflected in the 2002 NSFG data. For example, the contraceptive patch was approved by the U.S. Food and Drug Administration (FDA) in 2001 and had been used by only 1.5% of adolescents in 2002. Depot medroxyprogesterone acetate (DMPA or

The primary mechanism of action of combination oral contraceptives is the inhibition of ovulation. The progestin component of oral contraceptives also thickens the cervical mucus and makes it more hostile to sperm. The endometrial thinning that occurs with the combination oral contraceptives results in lighter, shorter menstrual periods but probably does not contribute to the contraceptive effect. Oral contraceptives are not abortifacients. The progestin component of the combination pills prevents the luteinizing hormone (LH) surge that triggers ovulation. Estrogen suppresses follicle-stimulating hormone (FSH) and follicular development. Traditional cycles of oral contraceptives arbitrarily consist of 21 days of hormonally active pills (estrogen and progestin) followed by 7 days of placebo pills. Bleeding occurs during the placebo week due to the withdrawal of hormones supporting the endometrium. Progestin-only contraceptives such as DMPA and progestin-only pills also inhibit ovulation, although not as efficiently as combination oral contraceptives. Other contraceptive effects of progestins include thickening of the cervical mucus, sufficient thinning of the endometrium to decrease the likelihood of implantation, and impaired motility of the fallopian tubes.

232 Adolescent Medicine: The Requisites in Pediatrics

Box 30-2 Conditions That Expose a

Evaluation

Woman to Increased Risk as a Result of Unintended Pregnancy

The evaluation of an adolescent female who requests contraception should include a review of medical conditions, current medications, menstrual history, social ­history, and family history.

l l l

Medical Conditions A publication of the World Health Organization (WHO) entitled Medical Eligibility Criteria for Contraceptive Use provides evidence-based ratings of the safety of specific contraceptive methods for women with various medical conditions (Box 30-1). Although specific hormonal methods may be relatively or absolutely contraindicated for women with certain medical conditions, pregnancy also poses significant risks for these women. The WHO therefore also lists those medical conditions that are associated with increased risk during pregnancy (Box 30-2), allowing a comparison of the contraceptive and pregnancy risks for a given condition. Most medical conditions that preclude the use of oral contraceptives (according to the WHO categorization) are uncommon in adolescents (Table 30-1). Migraine headache with aura, however, is not ­ uncommon and is considered a condition that poses an ­ unacceptable health risk for combination oral ­contraceptives. By logical extension, the contraindications to oral contraceptive use also apply to other combination hormonal methods, such as the transdermal patch and intravaginal ring. Although patient package inserts for combination and progestin-only methods often use similar lists of medical conditions that preclude use, the WHO guidelines reflect both international consensus and well-performed recent studies.

l l

l l l l l l l l l l

From: Medical Eligibility Criteria for Contraceptive Use, 3rd ed. Geneva, World Health Organization, 2004.

Table 30-1 Medical Conditions Precluding Oral Contraceptive Usea

Box 30-1 World Health Organization

(WHO) Medical Eligibility ­Ratings for Contraceptive Use

1. A condition for which there is no restriction for the use of the contraceptive method 2. A condition for which the advantages of using the method generally outweigh the theoretical or proven risks 3. A condition for which the theoretical or proven risks usually outweigh the advantages of using the method 4. A condition that represents an unacceptable health risk if the contraceptive method is used

Breast cancer Complicated valvular heart disease Diabetes: insulin-dependent; with nephropathy/ retinopathy/neuropathy or other vascular disease; or of > 20 years’ duration Endometrial or ovarian cancer High blood pressure (systolic > 160 mmHg or diastolic > 100 mmHg) HIV/AIDS Ischemic heart disease Malignant liver tumors (hepatoma) Schistosomiasis with fibrosis of the liver Severe (decompensated) cirrhosis Sickle cell disease Sexually transmitted infection (STI) Stroke Thrombogenic mutations Tuberculosis

Medical Condition

WHO Category

Thrombophlebitis or thromboembolic disorder Past history of deep vein thrombosis or thromboembolic disorders Cerebrovascular or coronary artery disease Valvular heart disease with thrombogenic complications Uncontrolled hypertension Diabetes with vascular involvement Headaches with focal aura Major surgery with prolonged immobilization Breast cancer Carcinoma of endometrium Other known or suspected estrogendependent neoplasia Undiagnosed abnormal genital bleeding Cholestatic jaundice of pregnancy Jaundice with prior pill use Acute or chronic hepatocellular disease with abnormal liver function, hepatic adenomas, or hepatic carcinomas Known or suspected pregnancy Hypersensitivity to any component of the product

4 4 4 4 4 3/4 4 4 4 1 Not discussed 2 2 3 4

Not applicable Not discussed

As listed in pill package inserts. Excerpted from: Hatcher RA, Nelson AL: Combined hormonal contraceptive methods. In: Hatcher RA, Trussell J, Stewart FH, et al. (eds): Contraceptive Technology. New York, Ardent Media, 2004, p. 412, with permission.

a

Contraception 233



Current Medications Drugs that may decrease the effectiveness of combination hormonal contraceptives are listed in Box 30-3. There are anecdotal reports of decreased effectiveness in women using broad-spectrum antibiotics, but studies have demonstrated that the serum levels of contraceptive hormones in subjects on antibiotics are well within the therapeutic range. Consequently, backup methods of contraception are not routinely recommended when antibiotics are prescribed for women on combination hormonal contraception.

Menstrual History Adolescents with a menstrual history of marked irregularity and/or amenorrhea of > 90 days should be evaluated for underlying medical conditions that will be masked, and possibly treated, with hormonal therapy. The most common disorders among adolescents that require consideration are polycystic ovary syndrome (PCOS) and eating disorders. Pregnancy as a cause of menstrual irregularity, oligomenorrhea, or amenorrhea must always be considered, and a urine pregnancy test should always be performed.

Social and Sexual History Confidentiality is particularly important when providing reproductive health services and contraception to adolescents.Whenever possible, policies regarding confidentiality should be discussed with the adolescent and parent on the first office visit. The challenge is to facilitate communication between the adolescent and parent or other supportive adults while simultaneously respecting the adolescent’s right to privacy and providing a setting in which the ­adolescent is comfortable discussing sexual behavior. The sexual history should include discussion of the age at first sexual intercourse; number of sexual partners; past and current condom use; past and current use of other contraceptive methods; history of sexually transmitted infections; and use of alcohol, tobacco, or illicit drugs. Substance use directly affects sexual history, both as an indicator of risk behavior and as a factor that

Box 30-3 Drugs That May Reduce Oral

Contraceptive Effectiveness

l l l l l

Antituberculous drugs Systemic antifungals Anticonvulsants Anti-HIV protease inhibitors Over-the-counter drugs l St. John’s Wort

decreases the likelihood of successful contraceptive use. Adolescent substance use is associated with unplanned sexual intercourse, inconsistent condom use, and ­multiple sexual partners. Parents may be concerned that tobacco use in adolescents significantly increases cardiovascular risks and thus precludes combination hormonal contraceptive use. Although combination oral contraceptives should not be used by smokers older than 35 years, the baseline cardiovascular risks in adolescent smokers are quite low and pregnancy increases the risks markedly (Figure 30-6). Thus, encouraging adolescents to stop smoking is good clinical care, but withholding oral contraceptives from adolescent smokers increases cardiovascular risks by increasing the risk of pregnancy.

Family History Family history is important when considering estrogencontaining hormonal contraception, particularly with regard to an inherited thrombophilia. History of venous thromboembolic disease without clear external cause (e.g., prolonged immobilization) in a first-degree relative should prompt evaluation. Adolescents and their mothers with a family history of breast cancer frequently ask about the risks of oral contraceptives. Among all women with a family history of breast cancer, oral contraceptives do not increase the risk of developing breast cancer, although women with known BRCA1 mutation may have a slightly increased risk.

Physical Examination Although careful history taking is important in adolescents who are seeking contraception, adolescents frequently are deterred from seeking care by the prospects of a gynecologic examination. The FDA has concluded that “physical examination may be deferred until after initiation of oral contraceptives if requested by the woman and judged appropriate by the clinician.” Good clinical practice dictates measurement of blood pressure, height, and weight; calculation of body mass index (BMI); determination of Tanner stages; and breast examination. Adolescents frequently and incorrectly believe that oral contraceptives are associated with weight gain. Progestin-only methods, particularly DMPA, have been associated with weight gain in adolescents. Establishing the baseline weight and helping the adolescent who has completed growth maintain it, regardless of contraceptive method, is a part of routine care. Urine-based testing for sexually transmitted infections is indicated for all sexually active adolescents, but the absence of testing should not prohibit the provision of contraceptives. Pelvic examination should be dictated by clinical judgment, and cervical

70

70

60

60

50

50

40

40

30

30

20

20

10

10 0

0

OC

, use

Cardiovascular mortality rate per 100,000

Cardiovascular mortality rate per 100,000

234 Adolescent Medicine: The Requisites in Pediatrics

ers

ok

sm

ncy

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Pre OC

, use

no

es

ett gar

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n

ttes

are

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15–

20–

25–

19

30–

24

35–

29

40–

34

39

44

Age

Figure 30-6 Estimated annual cardiovascular mortality rates associated with oral contraceptive (OC) use and smoking compared with pregnancy. Data from Schwingl PJ, Ory HW, Visness CM: Estimates of the risk of cardiovascular death attributable to low-dose oral contraceptives in the United States. Am J Obstet Gynecol 1999;180 (1 Pt 1):241–249.

cytology testing should begin approximately 3 years after the initiation of vaginal intercourse. Pelvic ­examination should not delay or deter contraceptive services.

Management Adolescents at risk for unintended pregnancy should be counseled about contraceptive options, regardless of the presenting complaint or reason for visit. This counseling can be challenging for the clinician and confusing for the patient. It includes the communication of a digestible amount of information; screening for medical contraindications or risks; dispelling of myths and misinformation; understanding of patient preferences; discussion about confidentiality; and parent or partner involvement if desired by the adolescent. Once a specific method is chosen by the patient, the clinician should review its effectiveness, correct use, medically serious risks, and bothersome side effects. Younger adolescents are at higher risk for discontinuation, incorrect use, and inconsistent use of all methods. Additional time and effort expended by the clinician to

help the adolescent use her chosen method correctly decreases the likelihood of a subsequent unintended pregnancy. Before leaving the office, the adolescent should understand when to initiate use of the method; its common side effects; serious side effects that should prompt immediate consultation and/or discontinuation; what to do if the method is forgotten or problems with use arise (including a phone number to call); when a follow-up visit is recommended; when to consider emergency contraception; and the importance of consistent and correct condom use. For many adolescents, emergency contraception may become an important option. In addition to enco­ uraging the selection and consistent use of a highly ­effective method, clinicians should counsel adolescents about the availability of emergency contraception by prescription. Emergency contraception has been judged to be safe and effective in preventing unintended pregnancies and abortions, even for young teens. Although political considerations have delayed over-the-counter availability, the advance provision of a prescription for emergency contraception should be considered for some adolescents seeking ­contraceptive services.



Table 30-2  Methods of Contraception

Duration Effectiveness of Use

Method

Characteristics

Combination oral contraceptive pills (OCs)

• Perfect use: • Combination 0.3% estrogen and progestin pills • Typical use: 8% • 21/7 formulation or extended cycle 84/7 or other (arbitrary regimen) • Monophasic or multiphasic formulations

Advantages and Indications

Disadvantages and Cautions

Medical Risks

Side Effects and Frequency

HORMONAL METHODS Daily pill• Decreased • Daily • No protection •  Breakthrough taking; dysmenorrhea administration from STIs spotting and ovulaand cycle• Need for refills •  Increased risk bleeding occur tion may related pain every 28 days for venous in 30–50% of be more (mittelschmerz) • Need for thromboembolic users in the first likely with • Decreased storage and phenomena month of use, extension menstrual blood daily access •  Small increased typically with of horloss risk for elevated resolution by mone-free • Decreased blood pressure the 3rd to 4th interval menstrual (BP) month of use molimina and •  Possible •  All other effects menstrual mood increased risk infrequent ( 14 weeks • Late reinserting ring ≥ 2 days •  Coitus interruptus practiced incorrectly •  IUD expelled •  Rape or sexual assault

Condoms: Male • Latex and non- •  Perfect use: 2% latex (polyurethane) as well •  Typical use: as intestinal 15% caecum (“natural skin”) •  Spermicidal lubricant as option; Nonoxynol-9 may increase risk of STI acquisition

Single use

•  By decreasing risk of STIs, help to preserve fertility •  Inexpensive •  Available without exam, prescription, or fitting •  Easy to use •  Male participation •  Portability

Chief Mechanism of Action

Specific Counseling Principles

- Zygote, mor- •  Discuss choice of ula, and ongoing blastocyst contraception developand need to ment and initiate new transport method in tube and •  Discuss the endomelack of protrial cavity - Developtection for ment of future acts of receptive unprotected uterine intercourse lining •  See clinician - Maintefor exam if nance of no period in necessary 3 weeks hormone levels by the corpus luteum •  Does not interrupt an established pregnancy— not an abortifacient BARRIER METHODS • Latex-allergic • Latex allergy individuals • Nonoxynolshould use 9 possibly polyurethane associated with condoms increased risk of •  Individual STI acquisition concerns about decreased sensitivity •  Disruption of spontaneity •  Problems with erection

Infrequent

Observe correct technique “start to finish”

Barrier to semen passage

•  Have condoms available •  Store in cool place •  Check expiration date •  Discuss condom use with partner •  Open carefully •  Use “start to finish” before any contact



•  Decreased risk of STIs (including HIV) when used consistently and correctly

Vaginal •  Physical barriers: barriers used female with condom, spermicide diaphragm, •  Varying contracepdesigns tive sponge, cervical cap, Lea’s Shield, FemCap

•  Female •  Single use Condom for female Perfect use: 5% condom, Typical use: sponge 21% •  Multiple •  Diaphragm use for Perfect use: 6% diaphragm, Typical use: cap 16% •  Device•  Sponge specific Perfect use: instrucParous 20% tions for Nulliparous length 9% of time Typical use: inserted Parous 32% prior to Nulliparous intercourse, 16% time left in •  Cervical Cap place after Perfect use: interParous 26% course, Nulliparous and need 9% to reapply spermicide with second act of intercourse

•  Minimal side effects •  Adolescents at risk for STIs should use in addition to hormonal methods

•  Embarrassment with purchase or discussion •  Coitusdependent • Lack of male cooperation •  Polyurethane condoms may be more likely to break than latex

•  Medically safe • No systemic effects •  Femalecontrolled method •  Use when contraception is needed intermittently •  STI protection likely

• Nonoxynol-9 • No systemic may increase effects of risk of STI spermicides acquisition • No risks with •  Increased risk fetal spermicide for UTI, bacteexposure rial vaginosis, and vaginal candidiasis •  Physical discomfort due to device •  Physical discomfort due to spermicide • Latex allergy (diaphragm, cap) •  TSS rare •  Fitting issues •  Difficulty removing (sponge)

•  UTIs, vaginal infections not uncommon • Latex allergy, especially in health care workers

TSS warning •  Physical signs: barrier to -  Sudden shield cervix high from semen fever •  When used -  Vomiting, with spermidiarrhea cide, killing -  Dizziness, sperm faintness, weakness -  Sore throat, aching muscles and joints -  Rash (like a sunburn)

•  Unroll correctly •  Water-based lubricants only, if required •  Hold condom in place at the base before withdrawing penis •  Check condom for damage •  If condom breaks, falls off, leaks, or not used: emergency contraception •  Do not reuse •  Combination of methods with condoms increases effectiveness (do not use male and female condoms together) •  Correct and consistent use • No douching after intercourse •  Avoid oil-based lubricants •  Specific method fitting (diaphragm, cap) •  Specific method instruction with insertion and removal •  Specific method instruction with repeated intercourse Continued

Table 30-2  Methods of Contraception—cont’d

Method

Characteristics

Duration Effectiveness of Use

Advantages and Indications

Disadvantages and Cautions

Medical Risks

Side Effects and Frequency

Warning Signs

Chief Mechanism of Action

Typical use: Parous 32% Nulliparous 9%

Spermicides

•  Formulations •  Perfect use: include gel, 18% foam, cream, •  Typical use: film, supposi29% tory, or tablet •  Increased •  Chemicals that effectivekill sperm in ness with different doses barrier and concentramethod tions

Coitusdependent with each act of intercourse

•  Over-thecounter use • No medical encounter required •  Femalecontrolled method •  Can be used when intercourse is infrequent •  Can be used as backup for hormonal methods

• Nonoxynol-9 • No systemic may increase effects of risk of STI spermicides acquisition • No risks with •  Allergy or senfetal spermicide sitivity to sperexposure micidal agents or ingredients in base •  Inability to learn correct insertion technique may limit use •  Possible risk of recurrent UTIs •  Vaginal irritation •  Waiting time for method to dissolve or disperse

Vaginal irritation

If used with vaginal barrier, watch for signs of TSS

•  Kills sperm •  Formulation helps disperse the spermicide •  Surfactants destroy sperm cell membrane

Specific Counseling Principles •  Have supplies and spermicide available •  Cleaning and disinfecting reusable methods (diaphragm and cap) •  Discuss emergency contraception •  Combination of methods with condoms increases •  Correct and consistent use • No douching after intercourse •  Specific method instructions for use •  Reuse with repeated intercourse •  Have supplies available •  Discuss emergency contraception

ECP, Emergency contraceptive pill; FDA, U.S. Food and Drug Administration; FSH, follicle-stimulating hormone; GnRH, gonadotropin-releasing hormone; HIV, human immunodeficiency virus; IUD, intrauterine device; LH, luteinizing hormone; OC, oral contraceptive; PCOS, polycystic ovary syndrome; PID, pelvic inflammatory disease; PMS, premenstrual syndrome; POP, progestin only pills; STI, sexually transmitted infection; TSS, toxic shock syndrome; UTI, urinary tract infection; WHO, World Health Organization.

Contraception 243





Table 30-3 Contraceptive Effectiveness Percent of Women Experiencing an Unintended Pregnancy Within the First Year of Use Method

Typical Use

Perfect Use

No method

85

85

Spermicides Withdrawal Periodic abstinence   Calendar   Ovulation   method   Sympto-thermal   Postovulation Cap   Parous women  Nulliparous   women Sponge   Parous women  Nulliparous   women Diaphragm Condom   Female (Reality)   Male Combined pill and minipilla Evra patchb NuvaRingc Depo-Provera Lunelled IUDe   ParaGard f   Mirenag Norplanth and Norplant-2i Female sterilization Male sterilization

29 27 25

18 4

l

Percent of Women Continuing Use at One Year

42 43 51

9 3

l

l

2 1

l

b

Unintended pregnancies among adolescents in the United States are common. Confidentiality is an essential aspect of contraceptive health care for adolescents. Successful use of contraception requires consistent, correct, and ongoing use. Hormonal contraceptives in general, and longer-acting methods in particular, provide effective contraception for adolescents. Most adolescents are healthy and have no contraindications to the use of hormonal contraception. Although use of specific hormonal methods may be relatively or absolutely contraindicated for patients with specific medical conditions, pregnancy also presents significant risks for these patients. Condoms should be encouraged for all adolescents, in addition to hormonal contraception. Advance provision of emergency contraception should be offered to all adolescents seeking ­contraception.

32 16

26 9

46 57

32 16

20 9

46 57

16

6

57

Bibliography

21 15 8

5 2 0.3

49 53 68

Abma JC, Martinez GM, Mosher WD, et al.: Teenagers in the United States: Sexual activity, contraceptive use, and ­ child­ bearing, 2002. Vital Health Stat: National Center for Health Statistics; 2004.

8 8 .3 3

0.3 0.3 0.3 0.05

68 68 56 56

American Academy of Pediatrics Committee on Adolescence: Emergency contraception. Pediatrics 2005;116:1026–1035. Epub 2005 Sep 1.

0.8 0.2 0.05

0.6 0.2 0.05

78 81 84

0.5 0.15

0.5 0.10

100 100

progestin only pill (POP) transdermal estrogen and progestin c intravaginal ring releasing estrogen and progestin d intramuscular progestin e intrauterine device f copper T g levonorgestrel intrauterine system (LNG-IUS) h subcutaneous 6-rod system releasing progestin i subcutaneous 2-rod system releasing progestin Excerpted from: Trussell, J: The essentials of contraception: Efficacy, safety, and personal considerations. In: Hatcher RA, Trussell J, Stewart FH, et al. (eds): Contraceptive Technology. New York,Ardent Media, 2004, p. 226, with permission. b

l

l

Emergency Contraceptive Pills: Treatment initiated within 72 hours after unprotected intercourse reduces the risk of pregnancy by at least 75%. Lactational Amenorrhea Method: LAM is a highly effective, temporary method of contraception. a

l

Major Points

l

Conard LA, Gold MA: Emergency contraception. Adolesc Med Clin 2005;16:585–602. Cushman LF, Romero D, Kalmuss D, et al.: Condom use among women choosing long-term hormonal contraception. Fam Plann Perspect 1998;30:240–243. Darroch J, Singh S, Frost J: Differences in teenage pregnancy rates among five developed countries: The roles of sexual activity and contraceptive use. Fam Plann Perspect 2001;33:244–250, 281. Dixon HS: Pelvic exam prerequisite to hormonal contra­ ceptives: Unjustified infringement on constitutional rights, governmental coercion, and bad public policy. Harv Women’s Law J 2004;27:177–233. DuRant RH, Smith JA, Kreiter SR, et al.: The relationship between early age of onset of initial substance use and engaging in multiple health risk behaviors among young adolescents. Arch Pediatr Adolesc Med 1999;153:286–291. Gallo M, Grimes D, Schulz K, et al.: Combination contraceptives: Effects on weight. Cochrane Review, The Cochrane Library, 2003. Grimes DA: No strings attached? Ob/Gyn News 2002.

244 Adolescent Medicine: The Requisites in Pediatrics Healthy People 2010—Reproductive Health. Office of Population Affairs, U.S. Department of Health and Human Services, 2001 (Vol 2001) . National Campaign to Prevent Teen Pregnancy: Fact Sheet: How Is the Thirty-Four Percent Calculated? Washington, D.C., National Campaign to Prevent Teen Pregnancy, 2004 (Vol 2004). Poulin C, Graham L: The association between substance use, unplanned sexual intercourse and other sexual behaviours among adolescent students. Addiction 2001;96:607–621. Rosenberg MJ, Burnhill MS, Waugh MS, et al.: Compliance and oral contraceptives: A review. Contraception 1995;52: 137–141.

Santelli JS, Abma J, Ventura S, et al.: Can changes in sexual behaviors among high school students explain the decline in teen pregnancy rates in the 1990s? J Adolesc Health 2004;35: 80–90. U.S. Food and Drug Administration: Labeling Guidance for Combination Oral Contraceptives. Washington, D.C.: U.S. Food and Drug Administration, 1994. Shulman LP: Counseling strategies to lead patients to successful contraceptive choices. The Female Patient Supplement 2005; 4–15. World Health Organization: Medical Eligibility Criteria for Contraceptive Use, 3rd ed. Geneva, WHO, 2004.

MENTAL AND BEHAVIORAL PROBLEMS

P a r t

Iv

245

C h Ap t e r

31

Introduction Definitions Epidemiology Pathophysiology Evaluation Genetic Testing Neuroimaging Multifactored Evaluation

Management Medical Home Immunizations Adaptive Equipment Adolescent Autonomy Psychosexual Counseling Health Insurance School Guardianship

Outcome

Introduction Mental retardation (mental retardation) and/or developmental disabilities (developmental disability) affect an estimated 1.5–4% of individuals in the United States. Ongoing advances in fetal, neonatal, and pediatric care are contributing to steady increases in the numbers of infants, children,and adolescents with significant neurodevelopmental and genetic conditions. These trends have prompted a gradual change in sociocultural attitude such that increasing proportions of children and adolescents with neurodevelopmental disabilities live at home with their families, attend school with typically developing peers, and are incorporated into community life. Consequently, clinicians who care for adolescents can expect to see increasing numbers of patients with developmental disabilities. Pediatricians, family practice physicians, and adolescent

Mental Retardation and Developmental Disabilities Thomas S. Webb, MD, MSc

medicine specialists commonly are asked to coordinate the health care provided by a multidisciplinary team and to facilitate access to educational and community services. This coordination requires an understanding of the spectrum of conditions that contribute to neurodevelopmental disabilities. The objectives of this chapter are to define the core concepts and conditions, review the epidemiology and pathophysiology of mental retardation and neurodevelopmental delay, and suggest approaches to evaluation and management.

Definitions Adaptive behavior is defined by the American Association on Intellectual and Developmental Disabilities the “collection of conceptual, social, and practical skills that people have learned so they can function in their daily lives.” Examples of conceptual skills include reading, writing, and money concepts. Social skills include developing interpersonal relationships, following instructions, and obeying laws. Practical skills are everyday activities such as bathing, toileting, dressing, preparing food, using the telephone, driving or using public transportation, shopping, paying bills, and working. Adaptive functioning can be assessed using standardized methods (i.e., the Vineland Adaptive Behavior Scales) to determine an age equivalence and standard score similar to IQ testing. The IQ and adaptive behavior scores can then be used to determine what levels of community supports would be beneficial to the individual. Developmental disability is defined by the Developmental Disabilities Assistance and Bill of Rights Act of 2000, Public Law 106–402, according to the five criteria noted in Box 31-1. Not all individuals with developmental disabilities have mental retardation, 247

248 Adolescent Medicine: The Requisites in Pediatrics

Box 31-1 Federal Definition of

Box 31-2 Definition and Classification of

A condition that:

Definition: Significant limitations of both intellectual function and adaptive behavior beginning at age 20 beats/min in pulse or > 10 mm HG in blood pressure) Electrolyte abnormalities Dehydration Cardiac arrhythmia Acute medical complication of malnutrition (e.g., syncope, seizure) Suicidal ideation, severe depression, or psychosis Uncontrollable binge/purge cycles Failure of an outpatient treatment program Comorbid diagnosis interfering with outpatient treatment (e.g., obsessive-compulsive disorder, substance abuse) Weight below 75% of ideal body weight

Golden NH, Katzman DK, Kreipe RE, et al.: Eating disorders in adolescents: Position paper of the Society for Adolescent Medicine. J Adolesc Health 2003;33:496–503.

278 Adolescent Medicine: The Requisites in Pediatrics

has now been reported in patients who are re-fed both orally and by nasogastric tube. Key components of refeeding syndrome are hypokalemia, hypophosphatemia, and hypomagnesemia due to the intracellular shifts that occur with transition from a catabolic to anabolic state. Complications can include cardiac arrhythmia, fluid overload, congestive heart failure, respiratory depression, ataxia, confusion, rhabdomyolysis, and renal decompensation.To prevent refeeding syndrome, energy intake should begin at 1000 kcal/day or 500 calories above the established outpatient diet, whichever is higher. Intake should then be increased by 250–300 kcal/day until the goal intake is achieved. Basic serum electrolytes, glucose, phosphorus, magnesium, and calcium should be monitored daily for several days, especially in patients with chronic starvation and critically low body weight. Cardiovascular complications: Resting bradycardia and autonomic dysregulation causing orthostatic pulse changes are almost universal in anorexia nervosa. Abnormally low sympathetic tone when supine, coupled with failure of the parasympathetic system to decrease tone when standing, can lead to dramatic orthostasis and syncope. These abnormalities correct approximately 3 weeks into the refeeding phase or when patients approach 80% of ideal body weight. Other cardiac changes include decreased left ventricular mass, mitral valve prolapse, QTc prolongation, arrhythmias, and ­sudden death. Gastrointestinal complications: Patients with anorexia nervosa have many gastrointestinal complaints. Purging is associated with esophagitis, dental enamel erosion and caries, and enlargement of the parotid and submandibular glands. The round face accompanying parotid gland hypertrophy can be particularly troubling to patients, reinforcing the drive for thinness. Rare complications such as pneumomediastinum, Mallory-Weiss tears, or gastric perforation have been reported. Abdominal pain and bloating are almost universal complaints early in the weight restoration phase of treatment due to delayed gastric emptying. Metoclopramide or other prokinetic agents may be useful in severe cases. Constipation, another common complaint, is best dealt with nutritionally. Mild elevations in liver enzymes reverse with refeeding and increased intestinal motility. Elevation in serum cholesterol is a result of increased liver production due to low fat and protein intake. Pancreatitis and cholelithiasis are complications seen with dramatic, rapid weight loss. Menstrual changes: The secondary amenorrhea seen in female patients with anorexia nervosa reflects hypogonadotropic hypogonadism, or suppressed secretion of gonadotropin-releasing hormone (GnRH). Serum levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), and estradiol are correspondingly low.

If the diagnosis of anorexia nervosa is unclear, the initial evaluation of amenorrhea should include measurement of serum LH, FSH, prolactin, thyroid-stimulating hormone (TSH), and a urine pregnancy test. Within 3 and 6 months of achieving weights within 90% of ideal, 36% and 86%, respectively, of female adolescents with anorexia nervosa will resume menses. Although those with persistent amenorrhea may have normal serum ­ levels of LH, FSH, and progesterone, studies suggest that their estradiol and leptin levels, fat intake, and body image remain lower than those of menstruating control patients. Other studies have linked depression to persistent amenorrhea in patients with histories of anorexia nervosa. Long-term follow-up studies have shown no increased risk of infertility in those women who achieve a healthy weight and return of menses. Bone mineral density (BMD): In both females and males with anorexia nervosa, bone mineral loss is inversely associated with BMI and directly associated with illness duration. Within 1 year of onset, up to 40% of patients have BMD measurements that are low compared with age-matched control standards. BMD measurement by dual-energy X-ray absorptiometry (DEXA) is therefore ­recommended for patients with anorexia nervosa who have been amenorrheic for 6–12 months. Although studies in healthy women demonstrate the positive effects of oral contraceptives on BMD, there are no data supporting their use for this purpose in females with anorexia nervosa. Preliminary studies of bisphosphonates and BMD in adolescents with anorexia nervosa do not demonstrate efficacy and, like oral contraceptives, their use for this purpose is not considered routine. Weight-bearing exercise in patients with anorexia nervosa demonstrates a dose-related effect on BMD, with exercise interfering with weight restoration. Calcium intake has not demonstrated consistent associations with BMD improvement and therefore should meet, but not exceed, the U.S. dietary guidelines. All adolescents should receive 1200–1500 mg calcium daily from calcium-rich foods or, alternatively, from oral supplementation. Studies of BMD in adolescents who have recovered from anorexia nervosa vary in their findings. Some demonstrate normalization of BMD with weight gain and resumption of menses, whereas others demonstrate improvement without complete normalization. Laboratory findings: Leukopenia, thrombocytopenia, and normocytic anemia are common in patients with anorexia nervosa and tend to resolve with improved nutrition and weight gain. Thyroid function studies typically reveal low serum thyroxine (T4) and triiodothyronine (T3) levels and normal levels of TSH, consistent with a “euthyroid sick” pattern. Thyroid replacement is not indicated in these patients and is likely to interfere with weight gain. Cortisol levels are generally high and patients

Eating Disorders 279



demonstrate blunted responses to adrenocorticotropic hormone (ACTH) stimulation testing. All of these abnormalities reverse with restoration of weight.

Bulimia Nervosa Definition Bulimia nervosa (Box 35-4) is defined as recurrent episodes of binge eating and compensatory behaviors to prevent weight gain, accompanied by an undue influence of body weight on self-esteem. The diagnosis can only be made in a patient who does not meet criteria for anorexia nervosa and should be distinguished from binge eating disorder, which has been proposed for inclusion as a formal DSM-IV diagnosis (Box 35-5). The diagnostic ­criteria for bulimia nervosa require an established frequency and duration of the episodes, which should be classified as purging or nonpurging types.

Epidemiology Bulimia nervosa has a prevalence of 1–3% in the general female population, and its incidence does not appear to have increased over the past two decades. First-degree relatives of individuals with bulimia nervosa are at four-fold risk for bulimia and 12-fold risk for anorexia. Long-term follow-up

Box 35-4 Diagnostic Criteria for Bulimia

Nervosa

l

l

l

l

l

Recurrent episodes of binge eating in which the person: l Eats an amount of food that is larger than most people would eat during a similar period of time. l Senses a lack of control over eating. Recurrent unhealthy compensatory behavior in order to prevent weight gain. The binge eating and inappropriate compensatory behaviors both occur, on average, at least twice a week for 3 months. Self-evaluation is unduly influenced by body shape and weight. Patient does not currently meet criteria for anorexia nervosa: l Purging type: person regularly engages in selfinduced vomiting or misuse of medications (e.g. laxatives, enemas, or diuretics). l Nonpurging type: person uses other inappropriate behaviors, such as fasting or excessive exercise, but has not regularly engaged in purging.

Adapted from: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. TR. (DSM-IV-TR). Washington, D.C., American Psychiatric Association, 2000.

of patients with bulimia nervosa demonstrate recovery in 50%, improvement in 30%, and persistence in 20%.

Pathophysiology The cause of bulimia is not known. As noted previously, there is a strong family disposition but neither a pattern of inheritance nor a gene locus has been identified. Depressive symptoms are reported in 75% of patients with bulimia, substance use in 25%, and personality ­disorders in up to 50%.

Evaluation The detection of bulimia nervosa represents the greatest challenge in its evaluation. Unlike the adolescent with anorexia nervosa who comes to medical attention with visible physical signs of illness, the adolescent with bulimia nervosa typically is normal weight and well-­appearing. Between binge/purge episodes, which are usually covert, eating may appear relatively normal. The health care visit therefore tends to be precipitated by the patient’s increasing emotional turmoil or by discovery of the purge episodes by family or friends. Clinician sensitivity to the adolescent’s embarrassment and upset are of paramount importance in the development of an effective therapeutic relationship, particularly when the ­adolescent has not initiated the care. The evaluation should include discussion of growth in height and weight, change in self-esteem or body image, peak and trough weight, fluctuation in weight, eating ­frequency and pattern, dieting, exercise, use of appetite suppressants or laxatives, and thoughts about food and eating. Most patients with bulimia describe excessive weight fluctuation, obsessive thinking about food, and

Box 35-5 Proposed Diagnostic Criteria

for Binge Eating ­Disorder

l

l

Recurrent episodes of binge eating that: l Occur without any compensatory behaviors (e.g. no purging). l Occur, on average, at least 2 days per week for 6 months. Binge eating episodes are out of control as indicated by the presence of at least three of the following: l Eating more rapidly than normal. l Eating until feeling uncomfortably full. l Eating large amounts of food even when not hungry.

Adapted from: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. TR. (DSM-IV-TR). Washington, D.C., American Psychiatric Association, 2000.

280 Adolescent Medicine: The Requisites in Pediatrics

anxiety about eating. The history should attempt to elicit symptoms consistent with dual diagnoses such as major depressive disorder, obsessive-compulsive disorder, and substance use given their high prevalence in patients with bulimia. The physical examination in bulimia may reveal hand abrasions from self-induced vomiting, dental caries from enamel erosion caused by gastric acid, and parotid enlargement. The most common laboratory findings are hypokalemia and metabolic alkalosis in patients with the binge/purge subtype.

Management Medical complications are much more common in patients with the purging than nonpurging type of bulimia nervosa. Repeated self-induced vomiting is associated spontaneous gastroesophageal reflux, loss of the gag reflex, dental enamel erosion, gingivitis, parotid gland enlargement, submandibular gland enlargement, esophagitis, Mallory-Weiss tears, and spontaneous pneumothorax. Constipation and atonic colon are associated with chronic use of laxatives. Electrolyte imbalance and dehydration are more common with purging but may also occur with severe binge eating, and is the leading cause of fatal arrhythmia in patients with bulimia nervosa. The primary treatment for bulimia nervosa in adults is cognitive-behavioral therapy (CBT). Manual-based treatment, originally developed by Christopher Fairburn, has been studied extensively in adults with bulimia nervosa and has demonstrated higher efficacy than other treatment strategies. CBT decreases binge eating by 73–93%, decreases purging by 77–94%, and improves body image. The use of an antidepressant medication in adults with bulimia nervosa and binge eating disorder yields shortterm resolution in 25%, with relapse in one-third despite continuation of the medication. In one study, the combination of CBT and an antidepressant demonstrated higher efficacy than either CBT or antidepressant alone. Medication trials in bulimia nervosa have consistently found antidepressants a useful adjunct to treatment independent of any patient symptoms of depression. Placebocontrolled trials of tricyclic antidepressants, monoamine oxidase inhibitors, and sustained serotonin reuptake inhibitors (SSRIs) have all demonstrated significant decreases in binge and purge episodes. Due to their safety and tolerability, SSRIs are preferred by many clinicians for the treatment of patients with bulimia nervosa. Fluoxitine trials demonstrate that patients receiving 60 mg daily reporting fewer episodes of binge eating and/or vomiting than those receiving 20 mg/day. Positive results have also been demonstrated with use of ondansetron. Medication alone for the treatment of bulimia nervosa is not recommended,and clinicians should ­emphasize

the importance of counseling. In a randomized study of CBT and desipramine, 18% of subjects on desipramine alone vs. 78% on desipramine and CBT were binge/ purge-free at 1-year follow-up. The practice guidelines of the American Psychiatric Association recommend medication continuation for at least 6, and preferably 12, months. At least one study supports continued CBT after medi­cation withdrawal to ­p revent relapse.

Eating Disorder Not Otherwise Specified DSM-IV defines eating disorders not otherwise specified (NOS) as abnormal eating behaviors, dissatisfaction with body weight or shape, and harmful weight control behaviors in the absence of full criteria for anorexia nervosa or bulimia nervosa. This is the most common set of eating disorders during adolescence, and management ­strategies are similar to those described previously.

 l

l

l

l

l

l

Major Points

b

Eating disorders are life-threatening mental health illnesses that require an interdisciplinary approach to treatment. Early diagnosis and intervention improves outcome in all eating disorders. Most adolescents with eating disorders respond best to outpatient, team-based care delivered by medical, mental health, and nutritional health providers. Indications for hospitalization include body weight below 75% of ideal, severe dehydration or electrolyte imbalance, bradycardia, hypotension, hypothermia, suicidal ideation, and uncontrollable binge eating or purging. Individual and family therapy are effective in ­adolescents with anorexia nervosa; findings from medication trials are inconsistent. CBT with or without an SSRI appears to be the most effective therapy for bulimia nervosa.

Bibliography Agras W, Rossiter E, Arnow B, et al.: One-year follow-up of psychosocial and pharmacologic treatment for bulimia nervosa. J Clin Psychiatry 1994;55:179–183. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. TR. Washington, D.C., American Psychiatric Association, 2000. Anonymous: Fluoxetine in the treatment of bulimia nervosa. A multicenter, placebo-controlled, double-blind trial. Fluoxetine



Bulimia Nervosa Collaborative Study Group. Arch Gen Psychiatry 1992;49(2):139–147. Bachrach LK, Guido D, Katzman D, et al.: Decreased bone density in adolescent girls with anorexia nervosa. Pediatrics 1990;86:440–447. Brambilla F, Monteleone P, Bortolotti F, et al.: Persistent amenorrhoea in weight-recovered anorexics: Psychological and biological aspects. Psychiatry Res 2003;118(3):249–257. Durakovic Z, Durakovic A, Korsic M: Changes of the corrected Q-T interval in the electrocardiogram of patients with anorexia nervosa. Int J Cardiol 1994;45:115–120.

Eating Disorders 281

Grice DE, Halmi KA, Fichter MM: Evidence for a susceptibility gene for anorexia nervosa on chromosome 1. Am. J. Hum Genet 2002;70:787–792. Robinson E, Bachrach LK, Katzman DK: Use of hormone replacement therapy to reduce the risk of osteopenia in adolescent girls with anorexia nervosa. J Adolesc Health. 2000;26:343–348. Shamim T, Golden NH, Arden M, Filiberto L, Shenker IR: Resolution of vital sign instability: An objective measure of medical stability in anorexia nervosa. J Adolesc Health 2003;32:73–77.

Fairburn CG, Marcus MD, Wilson GT: Cognitive-behavioral therapy for binge eating and bulimia nervosa: A comprehensive treatment manual. In: Fairburn CG, Wilson GT, eds. Binge eating: Nature, assessment, and treatment. New York: Guilford Press; 1993:361–404.

Solomon SM, Kirby DF: The refeeding syndrome: A review. J Parenter Enteral Nutr 1990;14:90–97.

Golden NH, Iglesias EA, Jacobson MS, et al.: Alendronate for the treatment of osteopenia in anorexia nervosa: A randomized, double-blind, placebo-controlled trial. J Clin Endocrinol Metab 2005;90:3179–3185.

Wilson GT, Fairburn CG, Agras WS: Cognitive-behavioral therapy for bulimia nervosa. In: Garner DM, Garfinkel PE, eds. Handbook of Treatment for Eating Disorders. 2nd ed. New York: Guilford Press; 1997:67–93.

Golden NH, Jacobson MS, Shebendach J, Solanto MV, Hertz SM, Shenker IR: Resumption of menses in anorexia nervosa. Arch Pediatr Adolesc Med 1997;151:16–21.

Yager J, chair, Work Group on Eating Disorders. Practice guideline for the treatment of patients with eating disorders. 3rd ed. American Psychiatric Association, 2006.

Golden NH, Katzman DK, Kreipe RE, et al.: Eating Disorders in Adolescents: Position Paper of the Society for Adolescent Medicine. J Adolesc Health 2003;33:496–503.

Walsh TB, Kaplan AS, Attia E, et al.: Fluoxetine after weight restoration in anorexia nervosa. A randomized controlled trial. JAMA 2006;295:2605–2612.

1 36

C hra p t e r h A pC te

Introduction Depressive Disorders Epidemiology Pathophysiology Evaluation Management

Mood Disorders Carol Engel, MD

Diagnostic criteria for MDD are shown in Box 36-1 and for dysthymic disorder in Box 36-2. Depressive disorder NOS is used when the number and/or duration of criteria for MDD or dysthymic disorder are not fully met or when the manifestations may reflect an underlying general medical condition or substance use disorder.

Bipolar Disorders Definitions Epidemiology Pathophysiology Evaluation Management Outcome

Introduction Mood disorders, also referred to as affective disorders, affect 7–14% of children and adolescents by age 15 years and are associated with significant morbidity and mortality. The diagnosis and management of adolescent affective disorders increasingly are the responsibilities of primary care physicians. The objectives of this chapter are to review the diagnostic criteria, evaluation, and primary care management of adolescent mood disorders. The chapter utilizes the categorization of mood disorders established in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, TR (DSM-IV-TR). The first section focuses on depressive disorders and the second on bipolar disorders.

Depressive Disorders The depressive disorders are further divided into major depressive disorder (MDD), dysthymic disorder, and depressive disorder not otherwise specified (NOS). 282

Epidemiology The point prevalence of MDD more than doubles between childhood and adolescence, from approximately 2% to 5%. The increase in dysthymic disorder may be even more dramatic, from less than 2% in children to as much as 8% in adolescents. The incidence, or new case rate, of MDD over the course of adolescence is 15–20%, which approximates the lifetime prevalence of MDD. These rates suggest that most adult depression begins during adolescence. Risk factors for adolescent depression are listed in Box 36-3. Most depressive episodes during adolescence resolve spontaneously within 6 to 9 months, and 90% resolve within 2 years. However, 40% of adolescents who experience a major depressive episode relapse within 2 years and 72% relapse within 5 years. The rates of depression in males and females are the same before puberty but diverge sharply during adolescence, with females outnumbering males by two to one.

Pathophysiology Evidence thus far demonstrates that depression results from a combination of genetic predisposition, biological factors, and environmental influences. Depression is not likely to result from a single defective gene, but rather multiple defects in minor genes of varying penetrance and expression. Several studies point to defects in the serotonin transporter gene as important in the pathogenesis

Mood Disorders 283



Box 36-1 DSM-IV-TR Criteria for the

Box 36-2 DSM-IV-TR Criteria for the

A. Five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Note: Do not include symptoms that are clearly due to a general medical condition, or mood-incongruent delusions or hallucinations. 1. Depressed mood most of the day, nearly every day, as indicated by either subjective report (e.g., feels sad or empty) or observation made by others (e.g., appears tearful). Note: In children and adolescents, can be irritable mood. 2. Markedly diminished interest or pleasure in all, or almost all, activities most of the day, nearly every day (as indicated by either subjective account or observation made by others). 3. Significant weight loss when not dieting, or weight gain (e.g., a change of more than 5% of body weight in a month), or decrease or increase in appetite nearly every day. Note: In children, consider failure to make expected weight gains. 4. Insomnia or hypersomnia nearly every day. 5. Psychomotor agitation or retardation nearly every day (observable by others, not merely subjective feelings of restlessness or being slowed down). 6. Fatigue or loss of energy nearly every day. 7. Feelings of worthlessness or excessive or inappropriate guilt (which may be delusional) nearly every day (not merely self-reproach or guilt about being sick). 8. Diminished ability to think or concentrate, or indecisiveness, nearly every day (either by subjective account or as observed by others). 9. Recurrent thoughts of death (not just fear of dying); recurrent suicidal ideation without a specific plan; or a suicide attempt or a specific plan for committing suicide. B. The symptoms do not meet criteria for a mixed episode. C. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning. D.  The symptoms are not due to the direct physiological effects of a substance (e.g., a drug of abuse, or a medication) or a general medical condition (e.g., hypothyroidism). E.  The symptoms are not better accounted for by bereavement (i.e., after the loss of a loved one), the symptoms persist for longer than 2 months, or are characterized by marked functional impairment, morbid preoccupation with worthlessness, suicidal ideation, psychotic symptoms, or psychomotor retardation.

A. Depressed mood for most of the day, for more days than not, as indicated either by subjective account or observation by others, for at least 2 years. Note: In children and adolescents, mood can be irritable and duration must be at least 1 year. B. Presence, while depressed, of two (or more) of the following: 1. Poor appetite or overeating. 2. Insomnia or hypersomnia. 3. Low energy or fatigue. 4. Low self-esteem. 5. Poor concentration. 6. Feelings of hopelessness. C. During the 2-year period (1 year for children or adolescents) of the disturbance, the person has never been without the symptoms in Criteria A and B for more than 2 months at a time. D. No major depressive episode has been present during the first 2 years of the disturbance (1 year for children and adolescents) (i.e., the disturbance is not better accounted for by chronic major depressive disorder or major depressive disorder in partial remission). Note: There may have been a previous major depressive episode provided there was a full remission (no significant signs or symptoms for 2 months) before development of the dysthymic disorder. In addition, after the initial 2 years (1 year in children and adolescents) of dysthymic disorder, there may be superimposed episodes of major depressive disorder, in which case both diagnoses may be given when the criteria are met for major depressive episode. E.    There has never been a manic episode, a mixed episode, or a hypomanic episode, and criteria have never been met for cyclothymic disorder. F.    The disturbance does not occur exclusively during the course of a chronic psychotic disorder, such as schizophrenia or delusional disorder. G. The symptoms are not due to the direct physiological effects of a substance (e.g., a drug of abuse or a medication) or a general medical condition (e.g., hypothyroidism). H. The symptoms cause clinically significant distress or impairment in social, occupational, or other important areas of functioning.

Diagnosis of Major Depressive Disorder (MDD)

From: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IV-TR). Washington, D.C., American Psychiatric Association, 2000.

Diagnosis of Dysthymic Disorder

Specify if: l l

Early onset: if onset is before age 21 years. Late onset: if onset is age 21 years or older.

Specify (for most recent 2 years of dysthymic disorder): l

With atypical features (i.e., mood reactivity and 2 or more of the following: increased appetite or weight gain, hypersomnia, leaden paralysis, long-standing pattern of extreme sensitivity to perceived interpersonal rejection).

From: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IV-TR). Washington, D.C., American Psychiatric Association, 2000.

284 Adolescent Medicine: The Requisites in Pediatrics

Box 36-3 Risk Factors for Adolescent Depression l l l l l l l l l l

Prior episodes of depression Attention-deficit/hyperactivity disorder (ADHD) Learning disorders Anxiety disorders Depressive disorder in parent or sibling Family dysfunction Loss of significant adult in early childhood Low parent–teen connectedness Low school connectedness Difficulty with peer relationships

of stress-induced depression. Family studies show that parental depression increases a child’s risk of depression four-fold, but the genetic and environmental contributions to this risk remain controversial. Neurohormonal dysfunction plays a role in the pathogenesis of depression, and pharmacotherapy usually targets neurotransmitters such as serotonin, norepinephrine, and acetylcholine. Table 36-1 summarizes the neuroreceptor effects of tricyclic antidepressants (TCAs), sustained serotonin reuptake inhibitors (SSRIs), bupropion, venlafaxine, and mirtazepine. Dysregulation of the neuroendocrine system may also play a role in depression. The hypothalamic-pituitaryadrenal axis is overactive in some adults with depression, as evidenced by elevated levels of corticotropic-releasing hormone. A few studies in adolescents with depression have shown elevated levels of evening cortisol compared with controls. Finally, studies indicate that depressed children and adolescents have blunted growth hormone secretion in response to stimulation.

Evaluation There is no single diagnostic test for depression. The diagnosis rests on the patient and family history, obser­

vations of the adolescent’s mood and behavior, and evidence of a change from the baseline level of function. The history should be obtained from the adolescent alone, the adolescent and parent/guardian together, and available medical and/or school records. It should include a discussion of present symptoms; review of past mental and medical illness, including evaluation, diagnoses, hospitalizations, and response to treatment; current medications; family history of mental illness; social history, including school performance and attendance; current or past use of alcohol or drugs; current or past abuse or neglect; peer ­relationships; sexual history; and mental ­ status ­examination (Table 36-2). Common manifestations of adolescent depression (Box 36-4) include irritability (the most common complaint), decreased school performance, social withdrawal, and increased conflict with peers or family. Many adolescents with depression present to their primary care providers with unexplained somatic complaints, such as headache or abdominal pain. The most common sleep disturbances associated with depression in adolescents are delayed sleep onset, frequent nocturnal awakening, difficulty with morning awakening, and daytime fatigue. Energy typically declines, although some adolescents complain of restlessness and agitation. Changes in appetite and weight are highly variable, with anorexia and weight loss in some teens and emotional eating with weight gain in others. There may be decreased interest in usual activities (i.e., apathy), a change in attitude toward school, refusal to attend school, feelings of hopelessness, and/or recurrent thoughts of death or ­suicide. Medical causes of depression or symptoms that may be misinterpreted as depression need to be considered in the evaluation. Examples include anemia; hypothyroidism; malnutrition due to an eating disorder, inflammatory bowel disease, or other chronic illness; infectious mononucleosis; adrenal insufficiency; and lupus cerebritis. It is particularly important to evaluate adolescents for use of alcohol, marijuana, and other illicit substances

Table 36-1 Neuroreceptor Effects of Antidepressant Medications

Serotonin reuptake inhibitor Norepinephrine reuptake inhibitor Dopamine uptake inhibitor Cholinergic antagonist

TCAs

SSRIs

Bupropion

Venlafaxine

Mirtazepine

++

++++

+/−

+++

−

+++

+

+

+++

++

− +++

+ Sertraline + Paroxetine

++ −

+ −

− ++

TCAs, tricyclic antidepressants; SSRIs, sustained serotonin reuptake inhibitors. + mild effect; ++ moderate effect; +++ strong effect; ++++ strong, predominant effect; − no effect; +/− minimal to no effect

Mood Disorders 285



Table 36-2  Mental Status Examination Component

Descriptors

Appearance, behavior

Overall presentation, appropriateness, grooming, eye contact, interpersonal interaction, relatedness Volume, pace, pressure level, articulation As perceived by the patient (e.g., happy, sad, hopeless) As perceived by others about the patient (e.g., labile, euphoric, bright, full, constricted, blunted, flat) Logical or disorganized, goal-directed or tangential, circumstantial, flight of ideas Suicidal, homicidal, paranoid ideations, delusions Hallucinations Estimated intelligence Patient’s understanding of his or her illness, ability to make good decisions

Speech, language Mood Affect

Thought process

Thought content Perception Cognition Insight, judgment

Box 36-4 Symptoms of Depression in

Adolescents

l l l l l l l l l l

Depressed or irritable mood Declining academic performance Delayed sleep onset, difficulty waking up Decrease energy level Restlessness or agitation Decreased appetite or weight loss Frequent somatic complaints Loss of interest in usual activities/withdrawal Low self-esteem, feelings of guilt Hopelessness or suicidal ideation or behavior

and to ­recognize that a diagnosis of depression should not be made when the adolescent is actively using drugs or alcohol. Treating the substance use disorder will alleviate the depressive symptoms in many, but not all, cases. Several screening tools for depression have been validated for use in adolescents, including the Children’s Depression Inventory, the Beck Depression Inventory, and the Reynolds Adolescent Depression Scale. These instruments can be helpful in confirming a diagnosis of depression and monitoring response to treatment but should not replace a thorough history and physical examination.

Management The mangement of depressive disorders in adolescents is multimodal and should address individual as well as ­environmental issues. Family therapy is recommended when there is a high level of family conflict. Psychoeducation should be included during these sessions. When school is causing excessive amounts of stress for the adolescent, the provider may collaborate with the school to help ensure that appropriate adjustments are made. Psycho­ logical testing may be helpful to determine whether there is comorbid attention-deficit/hyperactivity disorder (ADHD) and/or learning disability that may be contributing to the depression. Referral to a support group such as those dealing with divorce, grief and loss, sexuality, chronic illness, or anger management is recommended. If the stresses are interpersonal, individual psychotherapy is recommended. Cognitive behavioral therapy (CBT) and interpersonal psychotherapy have been shown to reduce symptoms of mild to moderate depression in adolescents. If the depression is more severe or if the adolescent fails to respond to these modes of treatment alone, pharmacological treatment may be necessary. SSRIs are the first-line pharmacological treatment for unipolar depression. Two randomized, placebo-controlled trials have shown that fluoxetine is both safe and effective in the treatment of depression in children and adolescents. This finding was replicated in the Treatment for Adolescents with Depression Study (TADS), a multicenter, randomized, clinical trial comparing fluoxetine with and without CBT to CBT alone and placebo. Results based on the Children’s Depression Rating Scale–Revised (CDRS-R) were as follows: Rate of response was highest in the fluoxetine plus CBT group (71.0%), followed by fluoxetine alone (60.6%), then CBT alone (43.2%), and lastly placebo (34.8%). It is generally recommended to start with a low medication dosage (i.e., fluoxetine 10 mg) and titrate to effect. Dose of fluoxetine used in TADS ranged from 20 to 40 mg. If an adolescent fails to respond to a therapeutic dose of an SSRI after 4 to 6 weeks, switching to an alternative SSRI may result in clinical improvement. Other SSRIs that may be used include sertraline, citalopram, escitalopram, or paroxetine. If the adolescent fails two SSRIs, then an alternative antidepressant should be considered. Augmentation therapy, or the addition of a second medication, can be considered if a comorbid condition exists with the depression or if the depressive symptoms do not respond adequately to an SSRI alone. One such strategy is the addition of bupropion (SR or XL).  This can be particularly helpful in adolescents with comorbid ADHD. In adolescents and adults with depression that is resistant to the inhibition of serotonin reuptake alone,

286 Adolescent Medicine: The Requisites in Pediatrics

the inhibition of both serotonin and norepinephrine reuptake with venlafaxine may yield improvement. Lithium carbonate plus an antidepressant has demonstrated effectiveness in adults with treatment-resistant depression but should be used with caution in adolescents because of side effects, potential toxicity, and suicidal risk. Tricyclic antidepressants generally are not recommended for use in adolescents for these same reasons, as well as limited evidence of efficacy. Other potential augmentation strategies include the addition of a psychostimulant (e.g., methylphenidate) or thyroid hormone (i.e., liothyronine or levothyroxine) to the anti­ depressant. As discussed in Chapter 39, the U.S. Food and Drug Administration issued a black-box warning in 2004 regarding to suicidal ideation when antidepressants are used for patients under age 18. This warning must be discussed with parents, and close monitoring for agitation and suicidal thoughts is recommended.

Bipolar Disorder A diagnosis of bipolar disorder (BPD) can be difficult to establish during adolescence. The manifestations commonly evolve during the second decade of life, and years may separate the first depressive and manic episodes. Consequently, the initial diagnosis given is often unipolar depression, anxiety, Panic disorder, or ADHD. It may be many years before the recognition and diagnosis of BPD.

Definitions DSM-IV-TR classifies BPD as BPD Type I, BPD Type II, Cyclothymic Disorder, and BPD NOS. Criteria for BPD Type I are listed in Boxes 36–5 and 36–6. Criteria for BPD Type II are listed in Box 36–7. Cyclothymic disorder is defined by numerous periods of hypomania and mild depression lasting at least 1 year (2 years for adults).The patient is not without symptoms for more than 2 months at a time. Adolescents with cyclothymia often progress to BPD Type I or II. BPD NOS includes those patients with bipolar features who do not meet the full DSM-IV-TR criteria. Children and adolescents are often given this diagnosis, as they often fail to meet full DSM-IV-TR criteria. Older adolescents may present with a more classic, adult-like presentation meeting all the criteria. As with depressive disorder NOS, BPD NOS can also be used when it is unclear whether the symptoms may be due to a medical condition or substance use disorder.

Box 36-5 DSM-IV-TR Criteria for the

Diagnosis of BPD Type I, Manic Episode

A. A distinct period of abnormally and persistently elevated, expansive, or irritable mood, lasting at least 1 week (or any duration if hospitalization is necessary). B. During the period of mood disturbance, 3 (or more) of the following symptoms have persisted (4 if the mood is only irritable) and have been present to a significant degree: 1. Inflated self-esteem or grandiosity. 2. Decreased need for sleep (e.g., feels rested after only 3 hours of sleep). 3. More talkative than usual or pressure to keep talking. 4. Flight of ideas or subjective experience that thoughts are racing. 5. Distractibility (i.e., attention too easily drawn to unimportant or irrelevant external stimuli). 6. Increase in goal-directed activity (either socially, at work or school, or sexually) or psychomotor agitation. 7. Excessive involvement in pleasurable activities that have a high potential for painful consequences (e.g., engaging in unrestrained buying sprees, sexual indiscretions, or foolish business investments). C. The symptoms do not meet criteria for a mixed episode. D. The mood disturbance is sufficiently severe to cause marked impairment in occupational functioning or in usual social activities or relationships with others, or to necessitate hospitalization to prevent harm to self or others, or there are psychotic features. E. The symptoms are not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication, or other treatment) or a general medical condition (e.g., hyperthyroidism). Note: Manic-like episodes that are clearly caused by somatic antidepressant treatment (e.g., medication, electroconvulsive therapy, light therapy) should not count toward a diagnosis of BPD Type I. From: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IV-TR). Washington, D.C., American Psychiatric Association, 2000.

Epidemiology The prevalence of BPD in adolescents is thought to be similar to that found in adults and is estimated to be about 1%. Lewinsohn et al. evaluated rates of BPD in high school youth aged 14 to 18 years. The lifetime prevalence was approximately 1%, and another 5.7% had subsyndromal symptoms warranting a diagnosis of BPD NOS. These adolescents had high rates of impairment similar to those

Mood Disorders 287



Box 36-6 DSM-IV-TR Criteri for the Diag-

Box 36-7 DSM-IV-TR Criteri for the Diag-

A. The criteria are met both for a manic episode and for a major depressive episode (except for duration) nearly every day during at least a 1-week period. B. The mood disturbance is sufficiently severe to cause marked impairment in occupational functioning or in usual social activities or relationships with others, or to necessitate hospitalization to prevent harm to self or others, or there are psychotic features. C. The symptoms are not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication, or other treatment) or a general medical condition (e.g., hyperthyroidism). Note: Mixed-like episodes that are clearly caused by somatic antidepressant treatment (e.g., medication, electroconvulsive therapy, light therapy) should not count toward a diagnosis of BPD Type I.

A. A distinct period of persistently elevated, expansive or irritable mood, lasting throughout at least 4 days, that is clearly different from the usual nondepressed mood. B. During the period of mood disturbance, 3 (or more) of the following symptoms have persisted (4 if the mood is only irritable) and have been present to a significant degree: 1. Inflated self-esteem or grandiosity. 2. Decreased need for sleep (e.g., feels rested after only 3 hours of sleep). 3. More talkative than usual or pressure to keep talking. 4. Flight of ideas or subjective experience that thoughts are racing. 5. Distractibility (i.e., attention too easily drawn to unimportant or irrelevant external stimuli). 6. Increase in goal-directed activity (either socially, at work or school, or sexually) or psychomotor agitation. 7. Excessive involvement in pleasurable activities that have a high potential for painful consequences (e.g., engaging in unrestrained buying sprees, sexual indiscretions, or foolish business investments). C. The episode is associated with an unequivocal change in functioning that is uncharacteristic of the person when not symptomatic. D. The disturbance in mood and the change in functioning are observable by others. E. The episode is not severe enough to cause marked impairment in social or occupational functioning, or to necessitate hospitalization, and there are no psychotic features. F.  The symptoms are not due to the direct physiological effects of a substance (e.g., a drug of abuse, a medication, or other treatment) or a general medical condition (e.g., hyperthyroidism). Note: Hypomaniclike episodes that are clearly caused by somatic antidepressant treatment (e.g., medication, electroconvulsive therapy, light therapy) should not count toward a diagnosis of BPD Type II.

nosis of BPD Type I, Mixed Episode

From: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IV-TR). Washington, D.C., American Psychiatric Association, 2000.

who received the diagnosis of BPD, Type I or II. In retrospective studies of adults with BPD, as many as 60% experienced the onset of symptoms before the age of 20 years; 10–20% had onset before age 10 years. The authors conclude that the diagnosis of BPD is often delayed by as much as 10 years.

Pathophysiology As with the depressive disorders, BPD is likely the result of multiple genetic variations as well as environmental factors. Although twin and adoption studies indicate that adult BPD is a heritable disease, studies in children and adolescents are limited. Some authors believe that earlyonset BPD may have an even stronger genetic link. Adolescents with a family history of BPD in a first-degree relative are two to three times more likely to develop a mood disorder. Brain imaging studies in adolescents with BPD have shown white matter hyperintensities predominantly in the frontal cortex and smaller amygdala volumes compared with normal controls. The frontal cortex is involved in control of impulses, judgment, sexual behavior, and socialization. The amygdala plays a key role in processing and storage of emotional stimuli.

Evaluation As with MDD, the diagnosis of BPD is made by clinical interview of patient and guardian. Careful analysis of

nosis of BPD Type II, Hypomanic Episode

From: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IV-TR). Washington, D.C., American Psychiatric Association, 2000.

present symptoms and family history will lead to the diagnosis. There is no single diagnostic test for BPD. Useful clinician scales include the Wash-U-KSADS and Young Mania Rating Scale. The Child Behavior Checklist is a useful parent rating scale. Adolescents often present with mood lability, extreme irritability, behavior changes, and/or aggressiveness. Mania, which is a criterion for the

288 Adolescent Medicine: The Requisites in Pediatrics

diagnosis of BPD Type I, is characterized by the symptoms noted in Box 36-8. Although older adolescents may have moods that cycle over weeks to months, younger adolescents may present with rapid, ultrarapid, or ultradian (daily) mood cycling. Classic euphoric mania is rare in both children and adults. The mood in BPD is more often irritable or dysphoric. Differential diagnosis is difficult and includes ADHD, oppositional defiant disorder, conduct disorder, and anxiety disorders. Each of these diagnoses can be comorbid with BPD. Warning signs that an adolescent who presents with depression may in fact have BPD are listed in Box 36-9. Early age of onset (before age 25 years) of a depressive ­episode is a risk factor for BPD. Frequent episodes of depression, failure to respond to antidepressant therapy, or tendency toward activation (worsening) with antidepressants are also warning signs for later development of BPD. Family history of BPD in a first-degree relative is a major risk factor (two to three times more likely). Medical conditions that might present with manic symptoms include hyperthyroidism, closed head injury, temporal lobe epilepsy, multiple sclerosis, systemic lupus erythematosus, and Wilson disease. It is important to screen for symptoms or family history of these conditions. Routine screening labs might include complete blood count, liver panel, renal panel, and thyroid-stimulating hormone (TSH). If there are neurological signs, especially if they are localizing, brain imaging is indicated. As is the case with the depressive disorders, a careful substance use history should be obtained. Adolescents abusing stimulants such as cocaine, amphetamine, ­psychostimulants, dextromethorphan, or steroids can present with manic symptoms. In addition, many adolescents with BPD may self-medicate with alcohol and other drugs. If substance use or abuse is suspected, it is useful to get a urine drug screen and blood alcohol concen­tration. Box 36-8 Symptoms of Mania in

Adolescents

l l l l l l l

l

l

Euphoric, elated, or extremely irritable mood Grandiosity Decreased need for sleep Pressured speech Racing thoughts or flight of ideas Distractibility Increased goal-directed activity (e.g., drawing or writing excessively) Excessive involvement in pleasurable or risky behaviors (e.g., hypersexuality) Psychosis (auditory or visual hallucinations or delusions)

Box 36-9 Risk Factors for BPD in

­Adolescents with Unipolar Depression

l l l l l l l

Early age of onset of a depressive episode Frequently recurring depression Poor response to antidepressant therapy Activation (worsening) with antidepressant Substance abuse Psychotic symptoms Family history of BPD

Management Pharmacotherapy is usually indicated for the management of BPD. However, most of the mood-stabilizers and atypical antipsychotics (see Chapter 39) used to manage BPD are considered off-label in children and adolescents due to the paucity of randomized controlled data in pediatric populations. In 2005, Kowatch, et al. published expert consensus guidelines for the acute management of BPD Type I with and without psychosis in patients aged 6 to 17 years. Guidelines were not developed for BPD Type II because the expert panel decided that the existing evidence base in children and adolescents was insufficient to support reliable recommendations. The algorithms for BPD Type I call for 4–8 week trials of each medication or combination of medications before moving on to another regimen. The expert panel emphasized that factors other than medication failure should be considered for patients who do not respond to treatment.These factors may include incorrect diagnosis of BPD, comorbid conditions, non-adherence to medication, and environmental or physiologic stressors. The algorithm for the acute manic or mixed phases of BPD Type I without psychosis calls for rapid initiation of monotherapy (stage 1) with a traditional mood stabilizer (e.g., lithium carbonate, valproate, or carbamazepine) or atypical antipsychotic (e.g., olanzapine, quetiapine, or risperidone). Although the panel leaned toward lithium or valproate because of their longer history and larger evidence base, the atypical antipsychotics may be better tolerated and do not require the monitoring of blood levels. If lithium or valproate is used, the controlled release formulation may help minimize side effects. The panel could not recommend the atypical antipsychotics ziprasidone and aripiprazole as initial monotherapy because of insufficient supporting data. If initial monotherapy yields partial improvement, augmentation therapy (addition of a second mood stabilizer or atypical antipsychotic) is recommended. For those with no response or significant side effects to initial monotherapy, alternative monotherapy (stage 2) with a drug not used previously is recommended. Failure to respond at this

Mood Disorders 289



level should prompt either a third trial of alternative monotherapy or a combination of two mood stabilizers (stage 3). Failure to respond at this level should be followed by a trial of three mood stabilizers (stage 4) and, finally, by trials of alternate monotherapy with oxcarbazepine, ziprasidone, or aripiprazole (stage 5). Non-response or intolerable side effects to stage 5 is followed by the stage 6 recommendation for clozapine or electroconvulsive therapy. The treatment algorithm for the acute manic or mixed phases of BPD Type I with psychosis is more aggressive than that for acute BPD Type I without psychosis. When psychosis is present, the expert panel recommends stage 1 therapy with both a traditional mood stabilizer (e.g., lithium or valproate) and an atypical antipsychotic (risperidone, olanzapine or quetiapine). This can be augmented by the addition of a third medication (i.e., another atypical antipsychotic) prior to the progression through the subsequent stages. Although the consensus panel did not develop a treatment algorithm for the acute depressed phase of BPD Type I, it did note that data in adults support the use of lithium in adolescents which is approved for age 13 years and older. Lamotrigine has also been shown to be effective treatment for the depressed phase in adults with BPD, but it must be initiated very slowly to decrease the risk of erythema multiforme major. Alternatively, bupropion or an SSRI may be added once the patient has improved on a mood stabilizer. Care should be taken with SSRIs because of potential mood destabilization and suicidal risk (see Chapter 39). Alternatively, bupropion SR or an SSRI may be added in once the mood has been stabilized with medication. Caution must be used with SSRIs because they can be mood destabilizing. It is important to treat comorbid conditions once adequate mood stabilization has been achieved. ADHD is the most common comorbid condition and should be treated with psychostimulants, atomoxitine, bupropion, or alpha2-agonists (clonidine or guanfacine). Psychotherapy for adolescents with BPD should be supportive with a focus on skill building for the adolescent. The therapist should aim to build rapport, which will improve compliance. As with the depressive disorders, psychoeducation of the family is critical. Emphasis should be on the importance of medication compliance and early recognition of relapse.

Outcome BPD typically follows an episodic course, with higher chronicity and poorer prognosis for earlier-onset disease. In a 4-year follow-up study of 86 youth with BPD, Geller et al. reported recovery and relapse rates of 87% and 64%, respectively. Risk factors for recurrence include low socioeconomic status, rapid cycling, mixed episodes, psychosis, and family conflict.

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Mood, or affective, disorders are categorized as MDD, Dysthymic Disorder, Depressive Disorder NOS, BPD Type I, and BPD Type II, Cyclothymic Disorder, and BPD NOS. lAlthough most depressive episodes during adolescence resolve spontaneously within 6–9 months, nearly three-quarters of adolescents who experience a major depressive episode will relapse within 5 years. Common manifestations of adolescent depression include irritability, decreased school performance, social withdrawal, and conflict with peers or family. Individual, interpersonal, and cognitive-behavioral therapy are considered first-line treatment options for adolescents with depressive disorders. Adolescents who do not respond may benefit from treatment with a low-dose SSRI or alternate antidepressant, titrated to effect (see Chapter 39). BPD is difficult to diagnose during adolescence.The 1% prevalence is thought to be similar to that of adults, but the recognition and diagnosis is commonly delayed by as much as 10 years. First-line treatment of BPD is pharmacologic, beginning with monotherapy with a mood stabilizer or atypical antipsychotic. More severe illness or the presence of psychotic symptoms may require combination drug therapy. Mood stabilization is the major goal of initial therapy. Once mood stabilization is achieved in adolescents with BPD, additional pharmacotherapy should be considered for comorbid conditions. Psychotherapy should be provided with a focus on skill building. Rates of episode remission and relapse in BPD are high, and earlier-onset disease follows a more chronic course and carries a poorer prognosis.

Bibliography American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IVTR). Washington, D.C., American Psychiatric Association, 2000. Brent DA, Birmaher B: Clinical practice. Adolescent depression. N Engl J Med 2002;347:667–671. Caspi A, Sugden K, Moffitt TE, et al.: Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science 2003;301:386–389. Centers for Disease Control and Prevention (CDC): Methods of suicide among persons aged 10–19 years — United States, 1992–2001. MMWR Morb Mortal Wkly Rep 2004;53:471–474.

290 Adolescent Medicine: The Requisites in Pediatrics Daviss WB, Bentivoglio P, Racusin R, et al.: Bupropion sustained release in adolescents with comorbid attention-deficit/ hyperactivity disorder and depression. J Am Acad Child Adolesc Psychiatry 2001;40:307–314. Delbello MP, Zimmerman ME, Mills NP, et al.: Magnetic reson­ ance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disord 2004;6:43–52. Emslie GJ, Heiligenstein JH, Wagner KD, et al.: Fluoxetine for acute treatment of depression in children and adolescents: A placebo-controlled, randomized clinical trial. J Am Acad Child Adolesc Psychiatry 2002;41:1205–1215. Essau C, Peterman F, (eds): Depressive Disorders in Children and Adolescents: Epidemiology, Course, and Treatment. Northvale, NJ, Jason Aronson, 1999, pp. 69–103. Geller B, Craney JL, Bolhofner K, et al.: Two-year prospective follow-up of children with a prepubertal and early adolescent bipolar disorder phenotype. Am J Psychiatry 2002;159: 927–933. Geller B, Tillman R, Craney JL, et al.: Four-year prospective outcome and natural history of mania in children with a prepubertal and early adolescent bipolar disorder phenotype. Arch Gen Psychiatry 2004;61:459–467.

Gotlib IH, Hammen CL, (eds): Handbook of Depression. New York, Guilford Press, 2002, pp. 192–218. Kessler RC, Walters EE: Epidemiology of DSM-III-R major and minor depression among adolescents and young adults in the National Comorbidity Survey. Depress Anxiety 1998;7:3–14. Kowatch RA, Fristad M, Birmaher B, et al.: Treatment guidelines for children and adolescents with bipolar disorder. J Am Acad Child Adolesc Psychiatry 2005;44:213–235. Lewinsohn PM, Klein DN, Seeley JR: Bipolar disorder during adolescence and young adulthood in a community sample. Bipolar Disord 2000;2(3 Pt 2):281–293. March J, Silva S, Petrycki S, et al.: Fluoxetine, cognitivebehavioral therapy, and their combination for adolescents with depression: Treatment for Adolescents with Dep­ ression Study (TADS) randomized controlled trial. JAMA 2004;292:807–820. Olfson M, Gameroff MJ, Marcus SC, et al.: Outpatient treatment of child and adolescent depression in the United States. Arch Gen Psychiatry 2003;60:1236–1242. Plotsky PM, Owens MJ, Nemeroff CB: Psychoneuroendo­ crinology of depression. Hypothalamic-pituitary-adrenal axis. Psychiatr Clin North Am 998;21:293–307.

37

ChAp t e r

Introduction Historical Perspective Epidemiology Pathophysiology Evaluation Management Outcome

Introduction Psychosis in children or adolescents presents physicians with perhaps the most challenging of clinical situations. These are young people who have difficulties across all lines of development and suffer interpersonal difficulties, perceptual disturbances, cognitive delays, and maladaptive functioning. The diagnosis of psychosis in young people can be devastating for families and costly for ­society. Psychosis has various definitions, but a common thread among them is severe impairment of mental functioning with disturbance in reality testing, or the inability to evaluate the external environment and differentiate it from one’s internal world. Reality testing requires accurate perception, organized thought processes, and flexibility in interpersonal interactions. Hallucinations and delusions, along with impairments in reality testing, are the classic characteristics of psychosis. The Diagnostic and Statistical Manual of Mental Disorders, 4th edition,Text Revision (DSM-IV-TR) divides psychotic disorders into the following diagnoses: schizophrenia, schizophreniform disorder, schizoaffective disorder, delusional disorder, brief psychotic disorder, shared psychotic disorder, psychotic disorder due to a general medical condition, substance-induced psychotic disorder, and psychotic disorder not otherwise specified (NOS). Psychotic features may be associated with mood ­disorders,

Psychotic Disorders Michael T. Sorter, MD Daniel A. Vogel, MD

trauma-related disorders, pervasive developmental disorders (PDDs), and personality disorders, but manifestations other than psychosis predominate. This chapter focuses on schizophrenia during adolescence. Its distinction from pervasive developmental and autistic disorders is discussed, followed by a review of its manifestations, evaluation, and management.

Historical Perspective The classification and diagnosis of psychosis in children has a long history of controversy. The first documented description by DeSanctis in 1906 identified a group of children who had significant developmental delays associated with social isolation, language abnormalities, and bizarre, inappropriate affect. Kraeplin subsequently noted that adult schizophrenia, which he termed dementia praecox, often began to manifest during adolescence. Kanner, Kolvin, and Rutter were the first to differentiate pervasive developmental delay (PDD) and autism as distinct from schizophrenia. PDD and autism spectrum disorders were described as early-onset, with high rates of mental retardation and seizure disorders, and rarely ­associated with hallucinations, delusions, and thought disorders. Childhood schizophrenia was described as later-onset symptoms, often associated with family sch­izophrenia, and predominated by thought disorders, ­ hallucinations, and delusions. DSM-IV-TR does not differentiate adult-onset from childhood-onset schizophrenia, reflecting evidence over the past 40 years ­demonstrating the evolution of symptoms over time. It does ­differentiate schizophrenia from diagnoses in the category of PDD (e.g., autistic disorder, Asperger syndrome, childhood disintegrative disorder, and Rett disorder). Although the cause of schizophrenia 291

292 Adolescent Medicine: The Requisites in Pediatrics

remains unknown, it is generally considered a neurodevelopmental ­disorder.

Epidemiology Schizophrenia is much more likely to be diagnosed in adolescents and adults than in children. The adolescent and adult rates are 2–4 per 10,000, compared with 2 per 100,000 before puberty. The age of onset peaks at 15–30 years. The male-to-female ratio decreases from approximately 2:1 during childhood to 1:1 during adolescence and adulthood. Premorbid factors that have been associated with schizophrenia include abnormal motor development, inattention, difficulty with information processing, diminished cognitive capacity, language delay, poor school performance, social isolation, and anxiety. However, no single factor demonstrates a consistent association and no set of factors reliably predicts the development of schizophrenia.

Pathophysiology Psychosis presents with manifestations that can be classified as positive and negative. Positive manifestations represent overproductions or distortions of normal functions (e.g., hallucinations, delusions, and disorganized speech). Negative manifestations represent deficiencies of normal functions, such as flattened affect, avolition, and diminished speech (i.e., alogia). The onset of schizophrenia is typically gradual, and the effect tends to be cumulative over time. Acute onset has been described but is unusual. Auditory hallucinations are described by 75% of patients with schizophrenia and constitute the most common presenting symptom. The hallucinations are usually brief phrases or a few words and often carry a negative message or command. The voices may be familiar or unknown, single or multiple, and engaged in conversation apart from the patient or directed toward the patient. Visual hallucinations are less common in schizophrenia than are auditory hallucinations, particularly after puberty. When present, they tend to be vivid, moving, and well defined. Delusions are reported in 50–85% of children and adolescents with schizophrenia. Abstract themes, paranoia, and mind control are more common in adolescents and adults than in children, who are more likely to describe delusions involving animals, ghosts, monsters, or unspecified fears. Formal thought disorders present as irrational, illogical, or tangential thinking; loose associations; magical thinking; and frank incoherence when severe. The presence of negative manifestations (e.g.,

flattened affect, diminished energy, social withdrawal, inattention, and apathy) tends to distinguish schizophrenia from other illnesses with psychotic features, such as bipolar disorder (BPD). Neurological findings in youth with schizophrenia are similar to those found in adults and include abnormal eye movements and cognitive delay. The most common manifestations of the cognitive delay are difficulties with information processing, attention, executive functioning, and memory. It has been estimated that 10–20% of patients with early-onset schizophrenia have borderline or mild mental retardation. The most common finding on computerized tomography (CT) or magnetic resonance imaging (MRI) in patients with schizophrenia is enlargement of the ventricular system with decreased brain volume and cortical gray matter, particularly in the medial temporal lobe, superior temporal gyrus, cingulate gyrus, thalamus, hippocampus, parahippocampus, and frontal lobe. The structural changes reflect abnormal neuronal migration and precede the onset of psychosis, supporting the view of schizophrenia as a neurodevelopmental disorder. Heritability is strong and consistent in family studies of schizophrenia. The risk of disease is 10-fold in firstdegree biological relatives of adopted individuals with schizophrenia. Fifty percent of offspring develop schizophrenia when both parents are affected, and the concordance rate in monozygotic twins is 50% as compared with 17% in dizygotic twins. Childhood-onset schizophrenia demonstrates stronger family associations than adult-onset schizophrenia. For example, disease rates among parents of affected individuals are 25% for childhood-onset schizophrenia compared with 11% for adultonset schizophrenia. Although susceptibility genes have not yet been identified, studies have demonstrated several chromosomal regions of interest. Environmental factors, such as low socioeconomic status, have been associated with schizophrenia, but there is little evidence supporting their role as causative. Although low socioeconomic status may contribute to disease development, it is also possible that disease in family members contributes to difficulties with employment and education. Studies of family function have demonstrated associations of high expressed emotion (e.g., hostility, criticism, overinvolvement, unclear communication, conflict) with both the development of schizophrenia during adulthood and relapse during adulthood.

Evaluation All areas of biological, psychological, and social functioning should be assessed in a child or adolescent with ­psychosis to ensure proper diagnosis and treatment (Box 37-1). The assessment requires collateral information from

Psychotic Disorders 293



Box 37-1 Evaluation of the Adolescent

with Psychosis

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History of present illness Age of symptom onset Course and nature of symptoms Precipitants Premorbid functioning Past psychiatric history School academic functioning Adaptive living skills Family history of psychiatric disorders Family stressors Family and cultural beliefs concerning illness Family strengths History of abuse, neglect, exposure to trauma Substance use history Developmental history—prenatal to current age

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Appearance Psychomotor activity Speech, communication, language, functioning Mood and affect Form and content of thinking Thought disturbances (i.e., delusions, ideas of reference) Perceptual disturbances (i.e., hallucinations) Level of consciousness and orientation Concentration Memory Fund of knowledge Insight Judgment Suicidality and/or homicidality Assessment of dangerousness and impulsive activity

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Adapted from: Sorter MT: Psychotic disorders. In Klykylo WM, Kay J (eds): Clinical Child Psychiatry, 2nd ed. London, John Wiley & Sons, 2005, pp. 433–446.

multiple informants and may take place over several sessions. It is important for the clinician to build a working alliance with family members because they will provide most of the historical information and contribute to the patient’s course and outcome. Although a thorough diagnostic evaluation may take several sessions, the initial evaluation must rule out delirium, organic conditions requiring immediate attention (e.g., drug overdose), and suicidal or homicidal ideation. Evaluation of hallucinations, delusions, thought disorder, the presence or absence of negative symptoms, and the duration and intensity of mood disturbance will often help distinguish primary psychotic disorders from affective disorders with psychotic features. There are many validated psychiatric interview schedules to assess psychotic symptoms and provide systematic evaluation of other key symptom areas. The Schedule for the Assess­ ment of Positive Symptoms (SAPS) evaluates hallucinations, delusions, bizarre behavior, and formal thought disorder. The Schedule for the Assessment of Negative Symptoms (SANS) evaluates flat affect, anergy, avolition, asociality, and inattention. The Kiddie PANSS is a modification of the Adult Positive and Negative Syndrome Scale. Psychological testing, including projective testing, may help clinicians assess the severity and nature of psychosis. Evaluation of cognitive ability, educational achievement, and adaptive living skills may reveal weaknesses that require attention, as well as strengths that will be relied upon in treatment. Evaluation of speech and language is especially useful in young patients because newonset, extreme disorganization in speech supports a diagnosis of schizophrenia or other underlying psychosis. Box 37-2 summarizes the differential diagnosis of schizophrenia. The medical evaluation begins with a thorough history and physical examination, often with neurology consultation. Baseline laboratory assessment should include a complete blood count; serum electrolytes, calcium, magnesium, and phosphorous; serum blood urea nitrogen and creatinine; erythrocyte sedimentation rate or C-reactive protein; serum liver and thyroid function tests, and toxicology screen. Substance use leads the differential diagnosis of psychosis in adolescents. Causes include the use of cocaine, amphetamines, hallucinogens, cannabis, phencyclidine, inhalants, and alcohol, as well as withdrawal from alcohol, barbiturates, benzodiazepines, and other sedatives. Chaotic family and social environments that place patients at risk of schizophrenia may also place them at risk for substance use and human immunodeficiency virus (HIV) infection. HIV screening is indicated for any adolescent with a history of substance use, sexual abuse, or consensual sexual activity. BPD and schizophrenia present with similar manifestations, including delusions, hallucinations, paranoia, and ideas of reference. BPD tends to be more episodic than

294 Adolescent Medicine: The Requisites in Pediatrics

Box 37-2 Differential Diagnosis of

Schizophrenia

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Psychotic disorder, NOS Schizoaffective disorder

Obsessive-Compulsive Disorder Post-Traumatic Stress Disorder l

Dissociative disorder

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Delirium Epilepsy Central nervous system (CNS) trauma or neoplasm

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Human immunodeficiency virus (HIV) infection Herpes encephalitis Neurosyphilis Encephalitis meningitis

Neurodegenerative Disease Metabolic Disorders

schizophrenia during adolescence, whereas negative symptoms appear more common in schizophrenia than BPD. The rates of positive symptoms, behavioral difficulties, and dysphoria do not appear to differ in adolescents with schizo­phrenia, BPD, and psychosis not otherwise ­specified (NOS). Children with early-onset ­schizophrenia,

compared with those with BPD or psychosis NOS, have higher rates of premorbid social withdrawal, more global impairment in function, and fewer friends. Long-term follow-up often is needed before a diagnosis of schizophrenia can be established (Box 37-3). Other diagnoses of childhood and adolescence that may be confused with schizophrenia include pervasive developmental disorders (PDDs), obsessive-compulsive disorder (OCD), and dissociative states. PDDs typically are apparent in early childhood and follow a chronic course, with significant impairments in language and social function. Delusions and hallucinations may occur in PDDs but tend to be less persistent than in schizophrenia. It is also important to recognize that illogical and immature patterns of communication may not reflect an underlying thought disorder. OCD is manifested by perseveration of thought, speech, and behavior. Although hallucinations are uncommon in OCD, obsessive thoughts and compulsive behaviors can accompany schizophrenia. Dissociative states and brief episodes of hallucination or distorted thinking may accompany post-traumatic stress disorder (PTSD) and borderline or schizotypal personality disorders. However, the symptoms tend to be more transient and intermittent in these disorders than in schizophrenia.

Management The treatment of schizophrenia requires the integration of multiple strategies to relieve psychotic symptoms, minimize developmental deviation, and maximize adaptive function. The care plan typically includes pharmacotherapy for the patient, counseling and education for the patient (see Chapter 39) and caregivers, and community resources to help relieve the emotional and financial strain on the family. Many studies have established the efficacy of neuroleptic medications in the management of schizophrenia during adulthood. The few studies conducted in children and adolescents demonstrate that medications are more effective than placebo for the control of hallucinations and delusions, but that the rates of relapse and side effects are high. Recent studies of atypical, or second-generation, antipsychotic medications in children and adolescents have been encouraging. A double-blind, randomized trial of clozapine demonstrated its superiority to haloperidol for mood stabilization and the management of psychosis. Open-label studies of children and adolescents have demonstrated the effectiveness of clozapine, risperidone, and olanzapine for the control of the positive and negative symptoms of schizophrenia. Common side effects are fatigue and weight gain for all three medications; nonspecific electroencephalographic changes and hypersalivation for clozapine; and extrapyramidal symptoms for risperidone. Open-label studies in adolescents with psychosis have demonstrated that quetiapine, aripiprazole,

Psychotic Disorders 295

Box 37-3 ­DSM-IV-TR Diagnostic Criteria

for Schizophrenia

A. Characteristic symptoms: Two (or more) of the following, each present for a significant portion of time during a 1-month period (or less if successfully treated): 1. Delusions 2. Hallucinations 3. Disorganized speech (e.g., frequent derailment or incoherence) 4. Grossly disorganized or catatonic behavior 5. Negative symptoms (i.e., affective flattening, alogia, or avolition) Note: Only one Criterion A symptom is required if delusions are bizarre or hallucinations consist of a voice keeping up a running commentary on the person’s behavior or thoughts, or two or more voices conversing with each other. B. Social/occupational dysfunction: For a significant portion of the time since the onset of the disturbance, one or more major areas of functioning such as work, interpersonal relations, or self-care are markedly below the level achieved prior to the onset (or, when the onset is in childhood or adolescence, failure to achieve expected level of interpersonal, academic, or occupational achievement). C. Duration: Continuous signs of the disturbance persist for at least 6 months. This 6-month period must include at least 1 month of symptoms (or less if successfully treated) that meet Criterion A (i.e., active-phase symptoms) and may include periods of prodromal or residual symptoms. During these prodromal or residual periods, the signs of the disturbance may be manifested by only negative symptoms or two or more symptoms listed in Criterion A present in an attenuated form (e.g., odd beliefs, unusual perceptual experiences). D. Schizoaffective and mood disorder exclusion: Schizoaffective disorder and mood disorder with psychotic features have been ruled out because either (1) no major depressive, manic, or mixed episodes have occurred concurrently with the active-phase symptoms; or (2) if mood episodes have occurred during active-phase symptoms, their total duration has been brief relative to the duration of the active and residual periods. E. Substance/general medical condition exclusion: The disturbance is not due to the direct physiological effects of a substance (e.g., a drug of abuse or a medication) or a general medical condition. F. Relationship to a pervasive developmental disorder: If there is a history of autistic disorder or another pervasive developmental disorder, the additional diagnosis of schizophrenia is made only if prominent delusions or hallucinations are also present for at least a month (or less if successfully treated). Reprinted with permission from: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IV-TR). Washington, D.C., American Psychiatric Association, 2000.

and ziprasidone are effective and well tolerated over the long term. Clinicians should educate patients and families about the risks, benefits, and side effects of all medications prescribed, particularly when the use is extrapolated from adult data and approval by the U.S. Food and Drug Administration (FDA) is lacking. Informed consent of the parent/guardian must be obtained, as well as assent of the patient when possible. Long-term potential side effects of antipsychotic medications, such as extrapyramidal side effects, tardive dyskinesia, weight gain, excessive sedation, cognitive blunting, hyperglycemia, changes in electrocardiogram (ECG), endocrine effects on thyroid hormones or prolactin elevation, hematological changes, and neuroleptic malignant syndrome require baseline and periodic evaluation. Each evaluation should include the determination of body mass index, a structured evaluation such as the Abnormal Involuntary Movement Scale (AIMS) to measure the presence or absence of any involuntary movements, appropriate laboratory data, and ECG. The psychosocial treatment plan must be well integrated and tailored to meet the specific needs of the individual patient at the appropriate developmental level. Children with schizophrenia may benefit from supportive psychotherapy, but traditional, insight-oriented psychotherapy generally is not recommended in the acute phases of illness. The combination of psychoeducational family treatment, medication, and social skills training has been shown to decrease relapse. Supportive and cognitive behavioral therapy has been shown to improve adaptive function, and cognitive enhancement therapy has been shown to improve neurocognition and processing speed in adults. Focused individual and group therapy may target deficits in activities of daily living, conflict resolution, problem solving, and social skills. Children and adolescents with schizophrenia often require special educational accommodations developed jointly by school and mental health professionals. The management of schizophrenia often requires a step-down strategy from hospitalization to day treatment to intensive outpatient care. Community mental health services may include in-home therapeutic care, therapeutic recreation, case management, and vocational rehabilitation for older adolescents and young adults.

Outcome Outcome data for children and adolescents with ­schizophrenia are limited. A review of 57 children and adolescents with onset prior to age 14 revealed improve-

296 Adolescent Medicine: The Requisites in Pediatrics

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Psychosis is a severe impairment of mental functioning with disturbance in reality testing, or the ability to evaluate the external environment and differentiate it from one’s internal world. Psychotic disorders include schizophrenia, schizophreniform disorder, schizoaffective disorder, and substanceinduced psychotic disorder. Psychotic features may be associated with mood disorders, trauma-related disorders, pervasive developmental disorders (PDDs), and personality disorders, but manifestations other than psychosis predominate. PDD and autism spectrum disorders are of earlier onset than schizophrenia and are more likely to be associated with mental retardation and seizure disorders. Schizophrenia in children is often associated with family schizophrenia and is characterized by thought disorders and delusions. Bipolar disorder and schizophrenia present with similar manifestations, including delusions, hallucinations, paranoia, and ideas of reference. Bipolar disorder tends to be more episodic during adolescence than is schizophrenia, whereas negative symptoms appear more commonly in schizophrenia than in bipolar disorder. Schizophrenia is much more likely to be diagnosed in adolescents and adults than in children. The adolescent and adult rates are 2–4 per 10,000, compared with 2 per 100,000 before puberty. The onset of schizophrenia is typically gradual, and the effect tends to be cumulative over time. The evaluation of an adolescent with psychosis must rule out delirium, organic conditions requiring immediate attention (e.g., drug overdose), and suicidal or homicidal ideation. The treatment of schizophrenia typically includes pharmacotherapy for the patient, counseling and education for the patient and caregivers, and community resources to help relieve the emotional and financial strain on the family. Recent studies of atypical, or second-generation, antipsychotic medications (e.g., clozapine, risperidone, olanzapine, quetiapine, aripiprazole, and ziprasidone) in children and adolescents with schizophrenia have been encouraging. However, side effects are common and FDA approval for use in children is often lacking. Although schizophrenia tends to become less disruptive and easier to manage with age, core symptoms and difficulties with social function typically persist in adulthood.

ment in one-quarter of patients, remission in one-quarter, and severe deficit in one-half. Other studies have demonstrated that up to 90% of patients remain on antipsychotic medication and that the rates of repeat hospitalization and residential placement are high. Adult studies have documented increased rates of early death from suicide or injury and low levels of employment and/or education. Factors that have been associated with poor outcome include poor premorbid functioning, early age of onset, and nonacute, insidious onset. Although schizophrenia does become less disruptive and easier to manage over the years, core symptoms and difficulties with social function persist. Bibliography American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IVTR). Washington, D.C., American Psychiatric Association, 2000. Asarnow JR, Tompson MC, McGrath EP: Annotation: Childhoodonset schizophrenia: Clinical and treatment issues. J Child Psychol Psychiatry 2004;45:180–194. Hogarty GE, Flesher S, Ulrich R, et al.: Cognitive enhancement therapy forschizophrenia: Effects of a 2-year randomized trial on cognition and behavior. Arch Gen Psychiatry 2004;61: 866–876. Lewis R: Should cognitive deficit be a diagnostic criterion for schizophrenia? Rev Psychiatr Neurosci 2004;29:102–113. McClellan J, McCurry C, Speltz ML, et al.: Symptom factors in early-onset psychotic disorders. J Am Acad Child Adolesc Psychiatry 2002;41:791–798. McConville BJ, Sorter MTL: Treatment challenges and safety considerations for antipsychotic use in children and adolescents with psychoses. J Clin Psychiatry 2004;65 (6 Suppl):20–29. McGuffin P, Own MJ, Farmer AE: Genetic basis of schizophrenia. Lancet 1995;346:678–682. Mueser KT, McGurk SR: Schizophrenia. Lancet 2004;363: 2063–2072. Nicolson, R, Brookner, BF, et al.: Parental schizophrenia spectrum disorders in childhood-onset and adult-onset schizophrenia. Am J Psychiatry 2003;160:490–495. Reimherr JP, McClellan JM: Diagnostic challenges in children and adolescents with psychotic disorders. J Clin Psychiatry 2004;65(6 Suppl):5–11. Riley B: Linkage studies of schizophrenia. Neurotox Res 2004;6:17–34. Sorter, MT: Psychotic disorders. In Klykylo WM, Kay J (eds): Clinical Child Psychiatry, 2nd ed. London, John Wiley & Sons, 2005, pp. 433–446. U.S. Institute of Medicine: Neurological, psychiatric, and deve­ lopmental disorders: Meeting the challenges in the developing world. Washington, D.C., National Academy of Sciences, 2001. Volkmar FR: Childhood and adolescent psychosis: A review of the past 10 years. J Am Acad Child Adolesc Psychiatry 1996;35:843–851.

38

C h A p t e r

Introduction Definitions Epidemiology Pathophysiology Genetics and Neurochemistry Neuroimaging Psychological Perspectives

Evaluation Management Outcome

Introduction Anxiety is an emotion that combines cognitive symptoms, such as apprehension and fear, with physical symptoms of sympathetic nervous system activation, such as sweating and tachycardia. It may be a normal response to a real environmental stress that improves alertness and readiness for reaction, or an abnormal response to an imagined or misperceived threat that impairs function. Anxiety disorders are chronic and/or recurrent manifestations of stress and worry that do not serve health and positive deve­lopment. Box 38-1 lists the diagnostic categories of anxiety according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition,Text Revision (DSM-IV-TR). This chapter focuses on those disorders that are common during adolescence: panic disorder, specific phobia, social phobia, obsessive-compulsive disorder, post-traumatic stress disorder, and generalized anxiety disorder.

Anxiety Disorders Daniel A. Vogel, MD

panic and in which help might be unavailable or escape difficult. It may occur with or without panic disorder. Panic is defined as intense apprehension, fear, or terror; a sense of impending doom; and physical symptoms of breathlessness, palpitations, chest pain, choking, or smothering. Panic attacks develop abruptly, peak within 10 minutes, and include at least four of the symptoms listed in Box 38-2. Panic disorder consists of recurrent panic attacks and persistent worry about the attacks or their consequences over at least a 1-month period. It may occur with or without agoraphobia and is not attributable to a medication, drug, or underlying medical condition. Specific phobias involve persistent and excessive or unreasonable anxiety provoked by the presence or

Box 38-1 Anxiety Disorders Defined by

DSM-IV-TR

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Definitions Agoraphobia is persistent concern about or avoidance of places or situations that might trigger

l

Panic disorder without agoraphobia Panic disorder with agoraphobia Agoraphobia without history of panic disorder Specific phobia Social phobia Obsessive-compulsive disorder Post-traumatic stress disorder Acute stress disorder Generalized anxiety disorder Anxiety disorder due to a general medical condition Substance-induced anxiety disorder Anxiety disorder not otherwise specified

From: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IV-TR). Washington, D.C., American Psychiatric Association, 2000.

297

298 Adolescent Medicine: The Requisites in Pediatrics

Box 38-2 DSM-IV-TR Symptoms of Panic l l l l l l l l l l l l

Sweating Trembling or shaking Breathlessness or choking sensation Chest pain or discomfort Nausea or abdominal distress Lightheadedness Feelings of unreality or detachment Fear of losing control or going crazy Fear of dying Paresthesias Chills or hot flashes Palpitations or pounding heartbeat

From: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IV-TR). Washington, D.C., American Psychiatric Association, 2000.

Box 38-3 DSM-IV-TR Definitions of

Obsessions and Compulsions

Obsessions

1. Recurrent and persistent thoughts, impulses, or images that are experienced, at some time during the disturbance, as intrusive and inappropriate and that cause marked anxiety or distress. 2.  The thoughts, impulses, or images are not simply excessive worries about real-life problems. 3.  The person attempts to ignore or suppress such thoughts, impulses, or images, or to neutralize them with some other thought or action. 4.  The person recognizes that the obsessional thoughts, impulses, or images are a product of his or her own mind (not imposed from without, as in thought insertion). Compulsions

anticipation of specific objects or situations and often leading to avoidance of those objects and situations. Adults with specific phobias typically present with panic attacks and perceive the anxiety as unreasonable. Children often do not perceive the anxiety as unreasonable and often present with crying, tantrums, or clinging behavior persisting at least 6 months. Avoidance or endurance of the phobic stimulus causes significant distress and interferes with daily function. Social phobia is anxiety provoked by exposure to certain social or performance situations and often leading to avoidance. The situations typically involve unfamiliar people, potential scrutiny, and potential humiliation. The diagnosis of social phobia in childhood requires the anxiety to occur in peer rather than adult settings. The fear or avoidance cannot be triggered by a medical or other mental health disorder, and if another disorder is present, the anxiety must be considered a separate entity. Obsessive-compulsive disorder (OCD) is characterized by obsessive thoughts that cause marked distress or anxiety and compulsive behaviors that serve to neutralize the anxiety (Box 38-3). The obsessions and compulsions consume more than an hour per day; interfere significantly with function; are recognized by adults and some children as unreasonable or excessive; and are not attributable to a medication, drug, or other condition. Post-traumatic stress disorder (PTSD) is characterized by re-experiencing a traumatic event, simultaneous symptoms of increased arousal, and the avoidance of trauma-associated stimuli. PTSD during adolescence requires history of exposure to an event(s) involving actual or threatened death or serious injury and a response to that event involving

1.  Repetitive behaviors (e.g., hand washing, ordering, checking) or mental acts (e.g., praying, counting, repeating words silently) that the person feels driven to perform in response to an obsession, or according to rules that must be applied rigidly. 2. The behaviors or mental acts are aimed at preventing or reducing distress or preventing some dreaded event or situation; however, these behaviors or mental acts either are not connected in a realistic way with what they are designed to neutralize or prevent or are clearly excessive. Reprinted with permission from: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IV-TR). Washington, D.C., American Psychiatric Association, 2000.

intense fear, helplessness, or horror (Box 38-4). The episodes of re-experience must recur for at least 1 month and must cause significant distress or social impairment. Generalized anxiety disorder (GAD) is characterized by at least 6 months of persistent and excessive worry that causes significant distress or functional impairment; is not explained by medication use, drug use, or another medical or mental health condition; and is associated with the symptoms shown in Box 38-5. Separation anxiety disorder (SAD) is excessive, developmentally inappropriate anxiety about separation from home or from objects/people to which the patient is attached. The diagnosis requires at least three symptoms (Box 38-6), onset before age 18 years, persistence at least 4 weeks, and no evidence that the condition is caused by medication, drug use, medical illness, or another mental health disorder.

Anxiety Disorders 299



Box 38-4 DSM-IV-TR Criteria for Post-

Traumatic Stress Disorder (PTSD) Symptoms

The traumatic event is persistently re-experienced in one (or more) of the following ways: l

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Recurrent and intrusive distressing recollections of the event, including images, thoughts, or perceptions. In young children, repetitive play may occur in which themes or aspects of the trauma are expressed. Recurrent distressing dreams of the event. In children, there may be frightening dreams without recognizable content. Acting or feeling as if the traumatic event were recurring (includes a sense of reliving the experience, illusions, hallucinations, and dissociative flashback episodes, including those that occur on awakening or when intoxicated). Note: In young children, traumaspecific re-enactment may occur. Intense psychological distress at exposure to internal or external cues that symbolize or resemble an aspect of the traumatic event. Physiological reactivity on exposure to internal or external cues that symbolize or resemble an aspect of the traumatic event.

Persistent avoidance of stimuli associated with the trauma and numbing of general responsiveness (not present before the trauma), as indicated by three (or more) of the following: l

l

l l

l l

l

Efforts to avoid thoughts, feelings, or conversations associated with the trauma. Efforts to avoid activities, places, or people that arouse recollections of the trauma. Inability to recall an important aspect of the trauma. Markedly diminished interest or participation in significant activities. Feeling of detachment or estrangement from others. Restricted range of affect (e.g., unable to have loving feelings). Sense of a foreshortened future (e.g., does not expect to have a career, marriage, children, or a normal life span).

Persistent symptoms of increased arousal (not present before the trauma), as indicated by two (or more) of the following: l l l l l

Difficulty falling or staying asleep. Irritability or outbursts of anger. Difficulty concentrating. Hypervigilance. Exaggerated startle response.

Reprinted with permission from: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IV-TR). Washington, D.C., American Psychiatric Association, 2000.

Box 38-5 DSM-IV-TR Anxiety Symptoms

for Generalized Anxiety Disorder (GAD)

l l l l l l

Restlessness or feeling keyed up or on edge Being easily fatigued Difficulty concentrating or mind going blank Irritability Muscle tension Sleep disturbance (difficulty falling or staying asleep, or restless, unsatisfying sleep)

Reprinted with permission from: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IV-TR). Washington, D.C., American Psychiatric Association, 2000.

Box 38-6 DSM-IV-TR Criteria for

Separation Anxiety Disorder (SAD)

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Recurrent excessive distress when separation from home or major attachment figures occurs or is anticipated. Persistent and excessive worry about losing, or about possible harm befalling, major attachment figures. Persistent and excessive worry that an untoward event will lead to separation from a major attachment figure (e.g., getting lost or being kidnapped). Persistent reluctance or refusal to go to school or elsewhere because of fear of separation. Persistently and excessively fearful or reluctant to be alone or without major attachment figures at home or without significant adults in other settings. Persistent reluctance or refusal to go to sleep without being near a major attachment figure or to sleep away from home. Repeated nightmares involving the theme of separation. Repeated complaints of physical symptoms (such as headaches, stomachaches, nausea, or vomiting) when separation from major attachment figures occurs or is anticipated.

Reprinted with permission from: American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IVTR). Washington, D.C., American Psychiatric Association, 2000.

Epidemiology The estimated prevalence of anxiety disorders during adolescence varies depending on the population studied and the methods used for diagnosis. Gender differences are small in childhood, but all anxiety disorders except OCD are more common in females than males by adolescence. The overall community prevalence of anxiety disorders in children, adolescents, and young adults is

300 Adolescent Medicine: The Requisites in Pediatrics

5–20%. When limited to adolescents, the overall community prevalence is 1–9%. The prevalence of anxiety disorders increases during adolescence and young adulthood, but the 4-year mean duration of symptoms at the time of diagnosis suggests under-recognition at younger ages. PTSD is probably the most common anxiety disorder of adolescence, affecting 24–35% of youth in urban settings. Risk factors for PTSD during childhood and adolescence include exposure severity, exposure timing, and parental reaction to their child’s exposure. Once symptoms appear, they may persist for many years. However, spontaneous recovery from PTSD may occur. Studies suggest that up to two-thirds of adolescents experience panic attacks and up to 15% of adolescents in clinical settings have social anxiety disorder. Community prevalence rates among adolescents for other anxiety disorders are as follows: GAD, 3–5%; SAD, 2–5%; panic disorder, 1–5%; specific phobia, 2–3%; and OCD, 1%.

(MRI) of adults with PTSD and depressive disorders, and lower left-brain activity has been reported in association with negative affect.

Psychological Perspectives During infancy, the primary caregiver responds to the infant’s cries of hunger, fatigue, cold, fear, etc. Over time, the child internalizes an expected pattern of relief from distressing sensations. Psychodynamic theories posit that inconsistent caregiving produces a learned pattern of anxiety. Studies suggest that this inconsistency may be caused by traumatic disruption of the parent–child relationship, negligence on the part of the caregiver, or temperamental inhibition on the part of the child. SAD and withdrawn behavior during childhood are associated with PTSD, social phobia, specific phobia, and agoraphobia during adolescence. It remains unknown, however, whether early intervention in childhood can prevent or ameliorate the adolescent disorders.

Pathophysiology Genetics and Neurochemistry Comorbidity, family predisposition, and responsiveness to sustained serotonin reuptake inhibitors (SSRIs) and other antidepressant medications suggest that anxiety and depressive disorders overlap in their genetic and/or neurochemical pathways. Key lines of evidence supporting genetic transmission of anxiety include the higher concordance of anxiety disorders in monozygotic than dizygotic twins; the association of anxiety traits with the short allele of the serotonin transporter gene; and the association of anxiety disorders and noradrenergic transmission with a region of chromosome 15. The genetics of OCD may differ from that of other anxiety disorders. For example, family studies indicate that OCD, but not other anxiety disorders, is strongly associated with tic disorders. Although other anxiety disorders respond to SSRIs as well as other types of antidepressants, OCD responds only to SSRIs. OCD, but not the other anxiety disorders, may occur as a pediatric autoimmune neuropsychiatric disorder associated with streptococcal infection (PANDAs) due to genetic vulnerability of the immune system.

Neuroimaging Neuroimaging studies indicate that PTSD and panic disorder are associated with baseline increases in right-sided hippocampal blood flow. Decreased cerebral blood flow occurs during hyperventilation, with even greater decreases during panic attacks. Decreased hippocampal volume has been noted on magnetic resonance imaging

Evaluation The evaluation of an adolescent with anxiety begins with a detailed history to establish symptom onset, context, frequency, and severity. The environmental or cognitive triggers, emotional responses, and associated physical manifestations should be determined. A thorough physical examination, including a mental status examination, should note common physical findings associated with anxiety disorders such as hypervigilance, autonomic arousal, and psychomotor agitation. Persistent tachycardia or hypertension, however, should raise suspicion of an underlying medical condition (e.g., hyperthyroidism), substance use, or medication affect. Patients with anxiety disorders should always be evaluated at baseline and monitored for the development of comorbid conditions such as depressive disorders, suicidal ideation or behavior, and substance use. Box 38-7 lists screening tools that may help identify and monitor anxiety. Although many of these scales are not designed specifically for adolescents, they can help with the assessment of symptom severity and response to treatment. Other mental health disorders that should be included in the differential diagnosis of anxiety include affective disorders; psychotic disorders with delusions; avoidant personality disorder; disruptive behavior disorders such as attention-deficit/hyperactivity disorder (ADHD), oppositional defiant disorder, and conduct disorder; and substance use disorder. Two-thirds of children with one anxiety disorder meet criteria for another, and one-third have at least three disorders. Of particular concern is the high prevalence of major depressive disorder and/or substance use disorder in adolescents with anxiety disorders.

Anxiety Disorders 301



Box 38-7 Screening Tools to Help Identify and Monitor Anxiety l l l

l l l l l

Vanderbilt Scales for Parent and Teacher Assessment Multidimensional Anxiety Scale for Children Screen for Child-Related Emotional Disorders (SCARED) Revised Children’s Manifest Anxiety Scale Hamilton Rating Scale for Anxiety Social Anxiety Scale Yale-Brown Obsessive-Compulsive Scale Acute Panic Inventory

Management Individual, group, and/or family counseling generally constitute the initial treatment for adolescents with anxiety disorders. Cognitive behavioral therapy (CBT) may be useful in younger adolescents with mild to moderate anxiety of recent onset. Older adolescents with severe anxiety or significant comorbidity typically require pharmacotherapy (see Chapter 39) in addition to CBT or psychotherapy. SSRIs are considered first-line pharmacotherapy for the treatment of anxiety disorders. Most SSRIs are used offlabel in children and adolescents because of inadequate pediatric data to support approval by the U.S. Food and Drug Administration (FDA). Data are most convincing for fluoxetine, fluvoxamine, and sertraline, but citalopram and escitalopram are also widely used for the treatment of anxiety. Randomized trials in adults support the use of fluoxetine and fluvoxamine for SAD, GAD, and social phobia; and the use of sertraline for generalized anxiety disorder. Regardless of which SSRI is used, adolescents and parents should be informed of the FDA’s black-box warning that SSRIs may increase the risk of suicidal ideation or behavior in adolescents (see Chapter 39). They also should be aware that treatment with SSRIs may require dosage adjustment over a 6– to 12– week period to achieve maximum effectiveness without undue side effects. Clomipramine and other tricyclic antidepressants have demonstrated efficacy in adults with various anxiety disorders, but SSRIs are generally regarded as safer and better tolerated. SSRIs and clomipramine are the only antidepressants shown to be effective for the treatment of OCD. Venlafaxine has proven efficacious for the treatment of GAD in adults but is not recommended for use in adolescents. Anxiety often improves with treatment of comorbid conditions. For example, the combination of SSRIs and stimulants may be used to treat comorbid anxiety and ADHD. Comorbid bipolar and anxiety disorders represent one of the most challenging therapeutic dilemmas in psychiatry, given the effectiveness of SSRIs for the

control of anxiety and their simultaneous potential to induce mania in bipolar disorder. The usual approach is to optimize mood-stabilizing agents prior to initiating SSRIs. Other medications that have been used to manage anxiety include benzodiazepines, buspirone, beta blockers, and clonidine. Placebo-controlled trials of benzodiazepines in adults with anxiety disorders have failed to consistently demonstrate long-term efficacy and, given the risk of addiction and abuse, they should be avoided in adolescents. For patients with severe anxiety ­uncontrolled by SSRIs, benzodiazepines can be used on a ­short-term, episodic basis. Limited data in adolescents suggest that buspirone may be effective for generalized anxiety disorder and that clonidine may be effective for the hyperarousal and re-experiencing symptoms of PTSD. Beta blockers have been used in adults with performance anxiety or panic disorder, but their use in adolescents has not been systematically studied. OCD should be treated with an SSRI for at least 12–18 months after achieving symptom remission before attempting gradual discontinuation over an 8-month period. Although relapse rates are as high as 90% within a few months of discontinuation, studies suggest that ongoing or maintenance CBT during the period of declining dosage may help sustain remission.

Outcome Longitudinal and retrospective studies suggest that spontaneous remission is unusual in patients with anxiety disorders, particularly if the symptoms are long-standing or severe. The best prognoses are for children with SAD or phobias. As noted earlier, adolescents with anxiety disorders often have been symptomatic for years prior to diagnosis and, even with treatment, experience a remitting and relapsing course of illness. The prepubertal onset of anxiety disorders has been shown to increase the risk of later mental health problems, including substance use disorder. GAD and panic disorder in children tend to be chronic and are associated with major depressive disorder during adolescence and GAD during adulthood. SAD in childhood increases the risk of separation difficulties, depression, and agoraphobia in adulthood. Social phobia in childhood negatively affects education, adult employment, and adult relationships and may increase the risk of adolescent substance use. The course of PTSD during adolescence is highly variable, as noted previously. Spontaneous remission is associated with mild symptoms that develop soon after the traumatic event, early intervention, and family support.

AU8

302 Adolescent Medicine: The Requisites in Pediatrics

 l

l

l

l

l

l

Major Points

b

Anxiety is an emotion that combines cognitive symptoms, such as apprehension and fear, with physical symptoms of sympathetic nervous system activation, such as sweating and tachycardia. Anxiety disorders affect 1–9% of adolescents. The most common diagnoses during adolescence are PTSD, GAD, SAD, panic disorder, specific phobia, and OCD. Comorbidity, family predisposition, and responsiveness to SSRIs suggest that anxiety and depressive disorders overlap in their genetic and/or neurochemical pathways. OCD differs from other anxiety disorders in its familial association with tic disorders and its autoimmune association with streptococcal infection. Other mental health disorders, such as depression, substance use, and ADHD, should always be considered in the differential diagnosis and as comorbidities of anxiety disorders. Counseling, CBT, and SSRIs constitute the major therapies for anxiety disorders. Spontaneous remission is more likely with SAD, phobias, and PTSD than with GAD, panic disorder, and OCD.

Bibliography American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, 4th ed. [Text Revision] (DSM-IVTR). Washington, D.C., American Psychiatric Association, 2000. Bernstein, GA, Shaw K: Practice parameters for the assess­ ment and treatment of anxiety disorders. J Am Acad Child Adolesc Psychiatry 2000;32:1089–1098. Cohen JA: Practice parameters for the assessment and treatment of children and adolescents with posttraumatic stress disorder. J Am Acad Child Adolesc Psychiatry 1998;37 (10 Suppl):4S–26S. King RA, Leonard H, March J: Practice parameters for the assessment and treatment of children and adolescents with obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry 1998;37(10 Suppl):27S–45S. Lewis M (ed): Child and Adolescent Psychiatry, A Comp­ rehensive Textbook. Philadelphia, Lippincott Williams & Wilkins, 2002. Morris TL, March JS (eds): Anxiety Disorders in Children and Adolescents, 2nd ed. New York, The Guilford Press, 2004.

39

C h A p t e r

Introduction Antidepressants Specific SSRIs Non-SSRI Antidepressants

Psychostimulants Antipsychotics Mood Stabilizers Other Agents

Introduction The aim of this chapter is to provide an overview of the psychotropic agents used most commonly in the treatment of adolescents with mental health and/or behavior problems. It is important to recognize that the pediatric literature on psychopharmacotherapy is scant, resulting in off-label use of these medications in patients of younger age or with different conditions than approved by the U.S. Food and Drug Administration (FDA). In addition, primary care providers often are asked to assume responsibility for adolescent pharmacotherapy due to a shortage of child psychiatrists. Clinicians who care for youth are therefore expected to provide first-line mental health care in the office setting and to help patients and parents make educated decisions about the types, risks, and benefits of medication. The number of prescriptions for psychotropic medications administered to youth has increased steadily over the past two decades. An estimated 6% of U.S. children and adolescents younger than age 20 years are prescribed psychotropic medications. The challenges faced by these youth and their families are considerable. Comorbidity, social stigma, home and school disruption, parental difficulty controlling their children’s behavior, and side effects contribute to delayed and erratic use of psychiatric medications. A team approach,

Psychiatric Pharmacotherapy Velissarios Karacostas, MD, PhD Paul R. Crosby, MD

shared by physicians, nurses, psychologists, and social workers, facilitates adherence to the treatment plan and provides support for patients, families, and health care providers. The medications discussed in this chapter are divided into the following five categories: antidepressants, psychostimulants, antipsychotics, mood stabilizers, and adjuncts to care. Generic names are used throughout the text, and common trade names are noted in the tables.

Antidepressants Selective serotonin reuptake inhibitors (SSRIs) are approved by the FDA for the treatment of adults with major depressive disorder (MDD), generalized anxiety disorder (GAD), social anxiety, eating disorders, post-traumatic stress disorder (PTSD), obsessive-compulsive disorder (OCD), premenstrual dysphoric disorder (PMDD), panic disorder, trichotillomania, and migraine headaches. One SSRI (fluoxetine) is approved for the treatment of children and adolescents with MDD. All SSRIs carry blackbox warning of increased risk for suicide. The warning was based on a pooled analysis of nine antidepressants in 4400 adolescents showing a slight increase in suicidal ideation and behavior and no cases of actual suicide. The FDA recommends that the use of antidepressants in adolescents include face-to-face contact weekly during the initial month, biweekly until week 12, and then as clinically indicated. Telephone contact between visits is also encouraged. The usual treatment of mild to moderate depression is individual psychotherapy, without medication. For more severe depressive symptoms in the absence of bipolar disorder (BPD), the recommended approach is an SSRI combined with psychotherapy. SSRIs can precipitate mixed or manic episodes in patients with BPD and should be avoided when the diagnosis is suspected. 303

304 Adolescent Medicine: The Requisites in Pediatrics

Most adolescents with MDD respond to low or moderate doses (Table 39-1). Treatment should continue for at least 4 weeks before increasing the dose, followed by an additional 2 to 4 weeks at a higher dose before assessing the drug’s effectiveness. Once an effective drug and dose are determined, treatment should continue at least 6–12 months before considering a taper off the medication for adolescents with no previous depressive episodes. Extrapolation from the adult literature has led to recommendations for 1- to 3-year maintenance pharmacotherapy for adolescents with two or more previous episodes or an episode accompanied by psychosis, severe impairment, or significant suicidality prior to treatment. General recommendations pertaining to the use of SSRIs in adolescents are listed in Box 39-1. The half-lives of various SSRIs, potential drug interactions, and common side effects, are shown in Table 39-2.

Specific SSRIs Fluoxetine (Prozac) is approved by the FDA for the treatment of MDD and OCD in children ages 7 years and above, as well as for MDD, OCD, bulimia nervosa, panic disorder, and PMDD in adults. Based on comparative efficacy data, it is considered first-line pharmacotherapy for the treatment of pediatric depression. The usual starting dose is 5–10 mg daily, although doses up to 20 mg daily are commonly begun in adolescents who do not have anxiety. The maximum dose is 1 mg/kg/day, or 80 mg daily. Prozac Weekly is an enteric-coated, delayed-release formulation, with a starting dose of 90 mg weekly. A 1week hiatus is recommended between the last immediate-release dose and the first delayed-release dose. Sertraline (Zoloft) is approved by the FDA for the treatment of OCD in children ages 6 years and above, as well as for MDD, panic disorder, PTSD, PMDD, and social anxiety disorder in adults. There are at least two randomized, double-blind, placebo-controlled trials showing its

efficacy in treating MDD in children as young as 6 years. The starting dose is 25 mg daily for children or 50 mg daily for adolescents, with a maximum dose of 3 mg/kg/ day, or 200 mg daily. Paroxetine (Paxil) is indicated in adults for the treatment of MDD, OCD, panic disorder, social anxiety disorder, social phobia, PTSD, and GAD. There is some evidence of its efficacy over placebo in treating pediatric OCD (ages 7–17 years) and social anxiety disorder (ages 8–17 years). The starting dose in children is 10–20 mg daily. The maximum dose is 0.7 mg/kg/day, or 60 mg daily. Although paroxetine has some anticholinergic effects and is mildly sedating, it has not demonstrated efficacy in the treatment of sleep disturbances. These side effects, its potent inhibition of CYP2D6, and the lack of placebocontrolled data in children make it a less desirable option in the treatment of pediatric depression. Citalopram (Celexa) is approved by the FDA for the treatment of adult MDD. It has shown efficacy over placebo in the treatment of MDD in children ages 7–17 years. The starting dose is 10–20 mg daily. The maximum dose is 0.7 mg/kg/day or 60 mg daily. Citalopram is often preferred for patients with medical problems or those on other medications because of its minimal CYP450 interactions. Escitalopram (Lexapro) is the active S-enantiomer of citalopram (which is a racemic mixture) and is indicated in the treatment of adult MDD. There are no pediatric placebo-controlled studies of escitalopram, but it is commonly used in pediatric patients to minimize potential side effects. Dosing is half that of citalopram, with a starting dose of 5–10 mg daily and a maximum dose of 20 mg daily. Fluvoxamine (Luvox) is approved by the FDA for the treatment of OCD in children ages 8 years and above. Dosing is divided twice daily. The starting daily dose is 25–50 mg and may be increased slowly every 4–7 days to a maximum daily dose of approximately 4 mg/kg, or 200 mg. Fluvoxamine has multiple and strong CYP450 interactions, making its concomitant administration with

Table 39-1  SSRI Dosing Trade Name

Generic

Common Daily Dose Range

Available Formulations

Prozac Paxil Zoloft Celexa Lexapro Luvox

Fluoxetine Paroxetine Sertraline Citalopram Escitalopram Fluvoxamine

5–40 mg 10–60 mg 25–200 mg 10–40 mg 5–20 mga 50–300 mgb

Capsule, liquid (mint) Tablet, liquid (orange) Tablet, syrup Tablet, liquid (mint) Tablet, oral solution Tablet

10 mg and 20 mg of Lexapro is bioequivalent to 20 mg and 40 mg of Celexa, respectively. Divided BID.

a

b

Psychiatric Pharmacotherapy 305



Box 39-1 General Recommendations for

the Use of SSRIs

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The selection of a particular SSRI must take into account potential drug–drug interactions associated with the SSRI half-life and effect on the cytochrome P450 (CYP450) enzyme system. Initiating SSRI treatment at low doses minimizes common, early side effects (e.g., restlessness, dizziness, diarrhea, sweating, nausea, headaches, initial insomnia) and promotes compliance. Failure to respond is defined as inadequate control of symptoms after at least 6 weeks on the maximum tolerated dose. Anxiety disorders typically require very low starting doses, higher maintenance doses than for MDD, and longer intervals between dose increases. Children who are fast vs. slow metabolizers (which can be determined by laboratory testing) differ in their therapeutic SSRI doses. Serum SSRI levels do not correlate with response and are not clinically indicated. Discontinuation syndrome can occur when an SSRI with a short half-life is stopped abruptly. Symptoms can include dizziness, nausea, insomnia, headache, vivid dreams, nervousness, asthenia, diarrhea, worsening mood, vomiting, irritability, visual disturbances, lethargy, anorexia, tremor, and paresthesias. Serotonin syndrome can occur when an SSRI is used with other serotonergic agents, such as tricyclic antidepressants. Symptoms can include agitation, excitation, muscle twitching, nausea, vomiting, diarrhea, chills, fever, confusion, diaphoresis, and dizziness. The risk of suicidal ideation is highest following SSRI initiation or change in dose. For adolescents with bipolar depression, the dose of lithium or valproate should be maximized and lamotrigine or an atypical antipsychotic should be added before considering SSRIs.

starting dose is 50–100 mg daily. The maximum dose is 150 mg daily in children weighing less than 150 lbs and 300 mg daily in those over 150 lbs. The sustainedrelease (SR) form is divided twice daily, and the XL form is administered once daily. Interval doses exceeding 200 mg and daily doses exceeding 400 mg are associated with increased risk of seizure. Buproprion has a lower incidence of sexual dysfunction than SSRIs. Mirtazapine (Remeron) is approved by the FDA for the treatment of MDD in adults, but there are no placebocontrolled trials to support its use in youth. An openlabel study in adolescents demonstrated good efficacy and tolerability with few side effects (most commonly fatigue, increased appetite, weight gain, and dizziness). Clinically, mirtazapine can be used for the treatment of MDD in adolescents when better-studied agents are not tolerated, or as an adjunctive agent in patients with insomnia because of its beneficial effect on sleep. Venlafaxine (Effexor XR) is FDA-approved for the treatment of MDD, GAD, and panic disorder in adults. Placebo-controlled trials in the pediatric population have failed to show efficacy. Duloxetine (Cymbalta) is a dual serotonin-norepinephrine reuptake inhibitor approved by the FDA for the treatment of MDD and diabetic peripheral neuropathy in adults. There are no studies of its use in youth. Nefazadone (Serzone), tricyclic antidepressants (TCAs), and monoamine oxidase inhibitors (MAOIs) are considered third- or fourth-line treatment choices in pediatric populations because of their lack of clear efficacy (there are more than a dozen negative trials with TCAs in youth with MDD), side effect profiles, and potential lethality in overdose. The use of these agents or a combination thereof to treat pediatric psychiatric disorders should take place in consultation with a pediatric psychiatrist. Table 39-3 lists common dose ranges for non-SSRI antidepressants.

Psychostimulants other medications difficult. Twice-daily dosing is also a disadvantage in pediatric patients. Fluvoxamine may be more likely than other SSRIs to cause nausea and vomiting.

Non-SSRI Antidepressants Buproprion (Wellbutrin, Wellbutrin SR, Wellbutrin XL) has both noradrenergic and dopaminergic effects. It is approved by the FDA for the treatment of MDD and smoking cessation in adults. There is some evidence suggesting modest efficacy in the treatment of pediatric attention-deficit/hyperactivity disorder (ADHD). The

Psychostimulants have been used to treat ADHD since 1937 and are approved by the FDA for use in patients aged 6 years and older. Chapter 32 discusses in detail the manifestations of ADHD, the behavioral and pharmacological strategies for its management, and the risks and side effects associated with psychostimulant use. Tables 39-4 and 39-5 summarize the pharmacokinetics of the commonly used psychostimulants. The formulations fall into three categories: methylphenidate, dextroamphetamine, and mixed salts of dextroamphetamine and amphetamine. A fourth category, pemoline, is no longer in use because of associated liver toxicity. Nonstimulant medications used in the treatment of ADHD (e.g., bupropion, atomoxetine) are discussed in Chapter 32.

306 Adolescent Medicine: The Requisites in Pediatrics

Table 39-2  SSRI Half-Lives, CYP450 Effects, and Drug Interactions Agent

Mean (Range) Half-Life

CYP450 Effects

Some Potential Drug Interactions

Fluoxetine

1–3 d (7–9 d)a

↓ 2D6

Paroxetine

24 hr (IR) 15–20 hr (CR)

↓ 2D6 and metabolized by 2D6

Sertraline Citalopram Escitalopram Fluvoxamine

25 hr (60–70 hr)b 35 hr 27–30 hr 15 hr

↓ 2D6 Weak ↓ 2D6 ↓ 2C9c, ↓ 2C19c ↓ 3A4, ↓ 1A2

↑ Pimozide, phenytoin,TCAs, carbamazepine, some antiarrhythmics Same as fluoxetine ↑ By cimetidine ↓ By phenobarbital and phenytoin Same as for fluoxetine Minimal Caution with anti-migraine agents ↑ Theophylline, warfarin, propranolol, diazepam, alprazolam

TCAs, tricyclic antidepressants. a Norfluoxetine. b Multiple metabolites. c Inhibition via a metabolite. ↓ Indicates enzyme inhibition or decrease of plasma drug levels. ↑ Indicates enzyme induction or increase of plasma drug levels.

Table 39-3 Non-SSRI Antidepressants Trade Name

Generic

Common Daily Dose Range

Available Formulations

Effexor (XR)a Wellbutrin (SR, XL)a Remeron

Venlafaxine Buproprion Mirtazipine

37.5–225 mg 100–300 mgb 15–45 mg

Serzone

Nefazadone

200–600 mgc

Capsule Tablet Tablet Sol Tab—rapid dissolution Tablet

Use of immediate-release formulation is not recommended. Dosing of SR is divided BID. c Dosing is divided BID. a

b

Table 39-4  Methylphenidate Formulations Trade Name

Hours to Peak

Duration (hours)

Ritalin Ritalin SR Ritalin LA

2 4.7 1–3, 5–7

3–5 8–12 8–12

Concerta

1–2, 6–8

10–12

Methylin

2

3–5

Methylin ER Metadate ER Metadate CD

4.7 4.5 1.5, 4.5

8 4–8 8–10

Focalina Focalin XRa

1–4 2, 6.5

3–5 12

Daytrana

a

D-isomer of methylphenidate.

9 or time of patch removal

    12

Delivery System Immediate-release tablet Sustained-release tablet Immediate-release (50%) and extended-release (50%) beads in a wax matrix Immediate-release (22%) from caplet cover, osmoticrelease (78%) from core Immediate-release chewable tablet, oral tablet, and oral solution Extended-release tablet Extended-release beads Immediate-release (30%) and extended-release (70%) beads in a capsule Immediate-release tablet Immediate-release (50%) and extended-release (50%) beads Transdermal patch with a steady plasma concentration

Psychiatric Pharmacotherapy 307



Table 39-5 Dextroamphetamine and Mixed Amphetamine Salts Trade Name

Hours to Peak

Duration (hours)

Dexedrinea Dexedrine Spansulea Adderallb Adderall XRb

1–3 8–10 1–3 3, 7

4–6 6–10 4–6 12

Vyvansec

4-6

12

Delivery System Immediate-release tablet Extended-release capsule Immediate release tablet Immediate-release and extendedrelease beads Pro-drug metabolized in the intestine

Dextroamphetamine. Mixed salts of dextroamphetamine and amphetamine. c Dextroamphetamine bound to L lysine. a

b

Psychostimulants are classified by the U.S. Drug Enforcement Agency (DEA) as Schedule II drugs and should be given cautiously to patients with a history of drug or alcohol abuse. Interestingly, studies show that children with ADHD who are treated with psychostimulants are less likely than those who are not treated with psychostimulants to develop substance use disorders. The FDA requires that the drug inserts for all psychostimulants include warning language about the potential risks of arrhythmia and sudden death. The evidence behind this requirement is discussed in detail in Chapter 32. Psychostimulant use is contraindicated in patients with histories of drug hypersensitivity, arrhythmia, glaucoma, or use of MAOIs within the preceding 14 days.

Antipsychotics Antipsychotic medications are classified as conventional (i.e., first-generation or neuroleptic) or atypical (i.e., second-generation) according to their side effect profiles. Conventional antipsychotics are associated with extrapyramidal side effects (EPSs) such as tremor, bradykinesia, rigidity, restlessness, and tardive dyskinesia (i.e., choreoathetoid movements, usually of the face). A rare but life-threatening EPS is neuroleptic malignant syndrome, which presents with autonomic instability including severe hyperthermia, significant elevation of creatinine phosphokinase (CPK), and leukocytosis. Studies of adults have demonstrated that atypical antipsychotics tend to have better efficacy and fewer side effects than conventional antipsychotics. Although controlled pediatric data are limited, the use of atypical antipsychotics has far surpassed that of conventional antipsychotics in children and adolescents, as well as adults. Tables 39-6, 39-7, and 39-8 summarize the side effects, monitoring, and doses of the six commonly used atypical antipsychotics. Weight gain is the most common side effect, with the

associated metabolic complications of Type 2 diabetes mellitus, dyslipidemia, and elevation of liver transaminases due to hepatic steatosis. Although the weight gain is most severe with clozapine and olanzapine and the metabolic complications are not associated with aripiprazole and ziprasidone, all six atypical antipsychotics carry the same black-box warning of these side effects. Risperidone (Risperdal) is widely used and highly effective but, compared to other antipsychotics, is associated with more pronounced elevations in serum prolactin levels and greater risk of EPS with rapid titration, use of high dose, and abrupt withdrawal. Children and adolescents should be started at the lowest possible dose, and titration must be gradual and guided by clinical response. If a decision is made to stop risperidone, the dose should be tapered gradually. It has received FDA approval for use in treatment of aggression in children with autism and for adolescents with BPD or psychosis. Olanzapine (Zyprexa) is effective for the treatment of adolescents with BPD but causes more weight gain in adolescents than in adults. It also is associated with increases in glycosylated hemoglobin, cholesterol, triglycerides, and excessive sedation. Quetiapine (Seroquel) is associated with excessive sedation, lightheadedness, and orthostatic hypotension. The sedation typically subsides with gradual titration to daily doses above 200 mg. Ziprasidone (Geodon) is associated with much less weight gain in adolescents than the other atypical antipsychotics. A baseline electrocardiogram should be performed due to potential dose-dependent QTc prolongation. Aripiprazole (Abilify) is associated with minimal risk of weight gain and EPS in adults. However, the clinical experience in adolescents has been equivocal, with case reports of both EPS and significant weight gain. It should be used with great caution when used with medications affecting 2D6-CYP450. Clozapine (Clozaril) carries high efficacy in the treatment of patients who are resistant to other antipsychotic medications. However, because of its high risk of

308 Adolescent Medicine: The Requisites in Pediatrics

Table 39-6 Antipsychotics: Comparison of Selected Side Effects Weight Gain Haloperidol Thioridazine Clozapine Risperidone Olanzapine Quetiapine Ziprasidone Aripiprazole +/− + ++ +++

Extrapyramidal

++ +++ ++++ +++ ++++ ++ +/− +

Prolonged QTc

++++ +/++ +/− ++++ +++ +/− ++ ++

++ ++++ + ++ + ++ +++ ++

Prolactin

Diabetes, Lipid

++++ ++++ + ++++ ++ + + +

++ ++++ + ++ + ++ +++ ++

Rarely occurs or occurs only at high dose. Mild effect or unlikely to occur at average doses. Moderate effect or moderately likely to occur at average doses. Significant effect or likely to occur at all doses.

++++ Severe effect or highly likely to occur at all doses.

Table 39-7  Atypical Antipsychotics: Monitoring Recommendations of the American Diabetes Association Baseline Personal/family history

X

Body mass index

X

Blood pressure

X

Waist circumference

X

4-Week

8-Week

12-Week

Quarterly

X

X

X

X

Annually

Every 5 Years

X X

X X

Fasting plasma glucose

X

X

Fasting lipid profile

X

X

X

Table 39-8  Atypical Antipsychotics: Doses and Formulations Generic

Trade Name

Daily Dose

Available Formulations

Risperidone

Risperdal

0.25–3 mg

Olanzapine

Zyprexa

2.5–20 mg

Quetiapine Ziprasidone Aripiprazole Clozapine

Seroquel Geodon Abilify Clozaril

12.5–800 mg 40–160 mg 2.5–20 mg 100–600 mg

Tablet, rapid-disintegrating M-tab, liquid Tablet, rapid-disintegrating Zydis, intramuscular Tablet Tablet, intramuscular Tablet, oral solution Tablet

agranulocytosis, it is recommended only for patients who have failed other medication trials. Other side effects are also common, such as weight gain, tachycardia, orthostatic hypotension, sialorrhea, fatigue, and constipation. The risk of seizures increases with dose, and there is evidence supporting an association with cardiomyopathy and congestive heart failure. It should be administered by psychiatrists familiar with its risks and the need for close monitoring.

Mood Stabilizers Mood stabilizers are used to treat acute mania and hypomania. The medications in this class include lithium, divalproex sodium (valproate), carbamazepine, and several newer antiepilectic drugs. Details of dosing, half-lives, serum levels, monitoring, side effects, and drug interactions are summarized in Tables 39-9, 39-10, and 39-11.

Psychiatric Pharmacotherapy 309



Lithium carbonate is approved by the FDA for acute and maintenance therapy of patients 12 years of age and older with manic episodes associated with BPD.There is some evidence supporting its use in children and adolescents with severe aggression and in those with the dual diagnoses of bipolar and substance use disorders. The response to lithium may be delayed 6–8 weeks in children and adolescents, resulting in its frequent use with faster-acting atypical antipsychotics.The starting dose of lithium is 150–300 mg daily, with increases of 300 mg every 3 days until an adequate dose (∼30 mg/kg/day) is achieved. Divided dosing (e.g., three times daily) is typically used early in treatment, but once- or twice-daily dosing is usually tolerated once a steady state is reached.The target serum level range is 0.8–1.2 mEq/L for acute treatment and 0.8–1.0 mEq/L for maintenance treatment. Discontinuation of lithium requires gradual downward titration by 300 mg every 3 days to avoid the precipitation of a manic episode. Lithium has been shown to prevent recurrent manic episodes,provide moderate prophylaxis for depressive episodes, and reduce the long-term risk of suicide. However, severe toxicity can occur at blood levels just two to three times higher than the therapeutic range. It therefore is essential to monitor levels closely, limit patient access to

large pill quantities, and repeatedly assess patient risk for suicide. Common dose-dependent side effects of lithium include polyuria (50–70%) and hypothyroidism (30%). Valproate is approved by the FDA for the treatment of acute bipolar mania in adults. Evidence supports its use for the treatment of acute mania in youth, and it is also commonly used in youth for maintenance treatment of BPD. Valproate may be particularly advantageous in patients with mixed and rapid cycling, cyclothymia, PTSD, panic disorder, and BPD with concurrent diagnoses of migraines, seizure disorder, or developmental disability. When used for the treatment of acute mania, rapid loading can be achieved with doses of 15–20 mg/kg/day. It is often started as a divided, twice-daily dose to minimize side effects but can be given once daily when a stable dose is reached. The dose should be increased as tolerated until clinical response is achieved, which typically occurs within a fairly wide therapeutic serum-level range of 85–120 μg/ml. Valproate carries a black-box warning for potentially lethal hepatic failure, with highest risk in patients younger than 2 years of age and in the first 6 months of treatment. Common side effects include gastrointestinal distress, cognitive dulling, weight gain, and alopecia.

Table 39-9  Mood Stabilizers: Doses and Formulations Generic

Trade Name

Daily Dose

Available Formulations

Lithium Valproate

Eskalith, Eskalith CR, Lithobid SR Depakote, Depakene, Depakon

300–2400 mg 500–1500 mg

Carbamazepine Lamotrigine

Tegretol Lamictal

400–1000 mg 100–400 mg

Tablet, capsule, syrup Tablet, capsule, syrup, intravenous Tablet, capsule, chewable, syrup Tablet, chewable

Table 39-10  Mood Stabilizers: Half-Lives, Serum Levels, and Monitoring Agent

Half-Life (hours)

Target Serum Level

Monitoring

Lithium

24

0.8–1.2 mEq/l

Valproate

9–16

85–120 μg/ml

Carbamazepine

18–55 initially, 5–20 ongoing*

6–10 μg/ml

Baseline BUN, creatinine, thyroid function tests, HCG, electrocardiogram; repeat every 6–12 months as indicated. Monitor serum drug level. Baseline complete blood count, liver function tests, amylase, lipase; repeat every 6–12 months as indicated. Monitor serum drug level. Baseline complete blood count, liver and thyroid function tests, BUN, creatinine; repeat every 6–12 months as indicated.

*Due to autoinduction with chronic dosing. BUN, blood urea nitrogen; HCG, human chorionic gonadotropin.

310 Adolescent Medicine: The Requisites in Pediatrics

Table 39-11 Mood Stabilizers: Serious Side Effects and Drug Interactions Agent

Serious Side Effects

Drug Interactions

Lithium

Interstitial nephritis, polyuria, nephrogenic diabetes insipidus, nephrotic syndrome, thyroid dysfunction, cardiac anomalies

↑ Level by thiazides (30–50%), NSAIDs, ACEIs. ↓ level by theophylline, caffeine.

Valproate

Hepatitis, pancreatitis, thrombocytopenia, neural tube defects, polycystic ovary syndrome

↑ Levels by salicylates, SSRIs, anticonvulsants, rifampin. May double level of lamotrigine and ↑ level of SSRIs.

Carbamazepine

Aplastic anemia, neutropenia, thrombocytopenia, hepatitis, SIADH, cardiac conduction delay, hypothyroidism

Auto-induction via potent ↑ of P450 enzymes. ↑ levels by SSRIs.

Lamotrigine

Stevens-Johnson Level doubled by syndrome, toxic valproate. ↓ epidermal level by other necrolysis, hepatic anticonvulsants. failure, hematological anomaliesa

Oxcarbazepine

Hyponatremia, hematological anomalies, hepatitis

↓ 2C19, ↑ 3A4, 3A5.

ACEIs, angiotensin-converting enzyme inhibitors; NSAIDs, nonsteroidal antiinflammatory drugs; SIADH, syndrome of inappropriate antidiuretic hormone. a Risks of these side effects are greatly reduced by slow initial titration of dosage. ↓ Indicates enzyme inhibition or decrease of plasma drug levels. ↑ Indicates enzyme induction or increase of plasma drug levels.

Neural tube defects are reported in 1% of infants born to mothers treated with valproate during pregnancy. Carbamazepine is indicated for the treatment of mania in adults. Open-label studies, case reports, and clinical experience support its use in children and adolescents with rapid-cycling BPD, acute mania, and severe impulsivity. However, there also are case reports of carbamazepine-induced mania in youth. Dosing is started at 200 mg nightly or divided twice-daily, and is increased slowly as tolerated until a therapeutic dose (10–30 mg/ kg/day) is achieved. Dosing is complicated by autoinduction of metabolism after 2–6 weeks of treatment. Slow titration of dose greatly minimizes occurrence and intensity of gastrointestinal distress, ataxia, vertigo, and slurred speech. Side effects that are dose-related include hematological anomalies, transaminase elevation, sedation, cognitive dulling, and ataxia. In pregnancy, carbamazepine may

increase incidence of neural tube defects, developmental delay, and craniofacial defects. Carbamazepine may reduce the effectiveness of oral contraceptives and many other psychotropics via potent CYP450 induction. Lamotrigine (Lamictal) was recently approved for the maintenance treatment of BPD in adults to prevent recurrent depressive episodes. Pediatric data are limited, and it should be used only in those adolescents who have failed other medication trials. Side effects are common on lamotrigine. Up to 10% of patients develop a benign maculopapular, erythematous rash that resolves with discontinuation of the drug. The likelihood of rash doubles when lamotrigine is used with valproate and is three times higher in children than adults. A black-box warning states that 1% of patients younger than 16 years and 0.1% of adults on lamotrigine develop life-threatening reactions such as Stevens-Johnson syndrome, toxic epidermal necrolysis, or angioedema. Slow initial dose titration minimizes the incidence of rash and other side effects. Dosing is started at 25 mg daily for 2 weeks and then is increased every 1–2 weeks by 25 mg until a maximum dose of 200 mg daily is reached. Unlike lithium and valproate, serum levels do not need to be monitored for lamotrigine. The metabolism of lamotrigine is decreased by valproate and increased by carbamazepine, and its dosing should be adjusted when used concomitantly with these drugs. When discontinuing lamotrigine, it should be tapered over 1 week. Topiramate (Topamax) is not approved by the FDA for the treatment of any psychiatric disorder but is used offlabel for the adjunctive treatment of weight gain associated with atypical antipsychotic therapy. Dosing in youth should start at 25 mg daily, with increases of 25 mg daily every 3 days until the desired effect on appetite and weight are achieved. Common side effects are cognitive dulling, memory impairment, confusion, nausea, and diarrhea. Less common effects are metabolic acidosis, nephrolithiasis, and glaucoma.

Other Agents Alpha-2 agonists (clonidine and guanfacine) are often used in the treatment of ADHD as second-line agents or to augment psychostimulants, even though they are not approved by the FDA for these uses. Although there are limited data on their effectiveness in the treatment of ADHD, clinical experience suggests that they are more helpful in the control of ADHD-associated aggression, impulsivity, tics, and insomnia than in the control of inattention. Clonidine (Catapres) is typically started at 0.05 mg at bedtime and can be titrated up to 0.1 mg three times daily. The major side effect is sedation. Guanfacine (Tenex) is less sedating than clonidine and can be started at 1 mg per day and titrated up to 1 mg three times daily. If either alpha-2 agonist is deemed ineffective after an

Psychiatric Pharmacotherapy 311



 l

l

l

l

l

l

l

l

Major Points

b

The pediatric literature on psychopharmacotherapy is scant, resulting in frequent off-label use of psychiatric medications in children and adolescents. Fluoxetine is the only SSRI approved by the FDA for the treatment of children and adolescents with MDD. SSRIs carry a black-box warning of increased risk for suicide based on studies showing a slight increase in suicidal ideation and behavior and no cases of actual suicide. SSRIs can precipitate mixed or manic episodes in patients with BPD and should be avoided until mood stabilization has been achieved. The selection of a particular SSRI depends on potential drug-drug interactions, half-life, and side effects. SSRI treatment should begin at low dose to minimize side effects. Discontinuation syndrome can occur with abrupt discontinuation, and serotonin syndrome can occur when the SSRI is used with other serotonergic agents. Psychostimulants are approved by the FDA for use in patients with ADHD ages 6 years and older. The FDA requires that drug inserts carry warning language about potential risks of arrhythmia and sudden death. Atypical antipsychotics tend to have better efficacy and fewer side effects than conventional antipsychotics. The most common side effect is weight gain, which is most severe with clozapine and olanzapine. There is also increased risk of developing metabolic syndrome (non-insulin–dependent diabetes mellitus, dyslipidemias). There is a need to monitor metabolic parameters (weight, fasting glucose, fasting lipid profile, insulin, body mass index, blood pressure) at baseline after 3 months and annually thereafter. Lithium carbonate is approved by the FDA for acute and maintenance therapy of patients aged 12 years and older with mania associated with BPD. Valproate and carbamazepine are widely used in children and adolescents with BPD but are not approved by the FDA for such use.

adequate trial, the medication should be tapered gradually over 1 to 2 weeks to avoid rebound hypertension. Ramelteon (Rozerem), a melatonin analog that binds to the same receptors as melatonin, was recently found useful in treating initial insomnia; it is much more potent than melatonin but is not FDA-approved for use in youth. Atomoxetine (Strattera) is a noradrenergic reuptake inhibitor used effectively in the treatment of ADHD in youth, especially those with comorbid anxiety (Chapter 32). It is considered a first-line agent in the treatment of ADHD but has a lower effect size than psychostimulants. Atomoxetine is more effective in treating inattention than hyperactivity or impulsivity at doses as high as 1.8 mg/kg (a dose higher than the manufacturer’s recommendation) and has the advantage of not being a Category II agent. However, full therapeutic dose is not achieved until at least several weeks. Modafinil (Sparlon) is a Category IV agent that is effective for treating excessive sleepiness. In March 2006, the FDA Advisory Committee for Psychopharmacologic Drugs voted not to recommend FDA approval of modafinil for the treatment of pediatric ADHD due to concerns over the risk of Stevens-Johnson syndrome and recommended that additional data be collected to support the safety of the drug in youth with ADHD. Bibliography American Diabetes Association, American Psychiatric Association, American Association of Clinical Endocrinologists, North American Association for the Study of Obesity: Consensus development conference on antipsychotic drugs and obesity and diabetes. J Clin Psychiatry 2004;65:267–272. Correll CU, Penzner JB, Parikh UH, et al: Recognizing and monitoring adverse events of second-generation antipsychotics in children and adolescents. Child Adolesc Psychiatr Clin N Am 2006;15:177–206. Findling RL, Steiner H,Weller EB: Use of antipsychotics in children and adolescents. J Clin Psychiatry 2005;66(Suppl 7):29–40. Kowatch RA, DelBello MP: Pediatric bipolar disorder: Emerging diagnostic and treatment approaches. Child Adolesc Psychiatr Clin N Am 2006;15:73–108.

Index

Note: Page numbers are followed by f for figures and t for tables. A AAFP. See American Academy of Family Practitioners AAP. See American Academy of Pediatrics Abacavir (ABC), 224t ABC. See Abacavir Abdominal migraine, 105 Abuse, 269 Acanthosis nigricans, 165 axillary, 169f ACL. See Anterior cruciate ligament Acne, 97 classification of, 98 epidemiology of, 97 evaluation of, 98 major points on, 103 management of, 98 myths vs. facts about, 99 oral antibiotics for, 99, 101t oral hormonal treatment for, 99, 102t oral isotretinoin for, 99 pathophysiology of, 97 patient interview for, 98 during puberty, 6–7 topical agents for, 98–99, 100t adverse reactions to, 101t efficacy of, 100t topical antibiotics for, 101t treatment for, 99t Acne fulminans, 98 Acne rosacea, 98 ACOG. See American College of Obstetricians and Gynecologists Acquired immunodeficiency syndrome (AIDS), 220, 222 ACS. See American Cancer Society Acute HIV seroconversion syndrome, 220 Acute retroviral syndrome, 220

ADA. See American Diabetes Association Adapalene, 100t Adaptive equipment, for DD, 252 Adaptive function, 247 Adderall, 260t Adderall XR, 260t Addiction, 269 ADHD. See Attention-deficit/hyperactivity disorder Adnexa, 175 Adnexal torsion, 175, 177 epidemiology of, 177 evaluation of, 177 management of, 177 pathophysiology of, 177 Adolescent autonomy, DD and, 252 Adolescent self-care readiness, internet resources for, 253 Adrenarche, premature, 165 Adult health care, transition to, 39 critical steps in, 39 developmental approach to, 39 domains of, 40 flexibility and, 41 health insurance and, 40 IDEA and, 40 IEP and, 40 issues in, 40 major points in, 42 planning for, 39 transfer tools for, 40 Advocacy, chronic health conditions and, 35 Affective cognition, 3 Agoraphobia, 297 AIDS. See Acquired immunodeficiency syndrome Alcohol use, 269. See also Substance use T1DM and, 87 Alpha-2 agonists, 310–311 313

314 Index

AMA. See American Medical Association Amastia, 146 Amazia, 146 Amenorrhea, 153 differential diagnosis of, 153 hypothalamic causes of, 153 ovarian causes of, 154 pathophysiology of, 153 pituitary causes of, 154 American Academy of Family Practitioners (AAFP), 9 American Academy of Pediatrics (AAP), 9 American Cancer Society (ACS), 206 American College of Obstetricians and Gynecologists (ACOG), 206 American Diabetes Association (ADA), 83–84 American Medical Association (AMA), 9 American Society for Colposcopy and Cervical ­Pathology (ASCCP), 208 Amiloride, 79t Amitriptyline, 108t Amlodipine, 79t Amphetamine, effects of, 272t Amphetamine salts, mixed, dextroamphetamine and, 307t Androgen insensitivity syndrome, 155 Anogenital warts, HPV and, 205 Anorexia nervosa, 276 bone mineral density and, 278 cardiovascular complications of, 278 definition of, 276 diagnostic criteria for, 276 differential diagnosis of, 277 epidemiology of, 277 evaluation of, 277 gastrointestinal complications of, 278 hospitalization criteria for, 277 laboratory findings of, 278–279 management of, 277 menstrual changes with, 278 pathophysiology of, 277 refeeding syndrome and, 278 Ansel criteria, for bacterial vaginosis, 187 Anterior cruciate ligament (ACL), sprain/tear, 120 Antiandrogens, for PCOS, 172 Anticipatory guidance, for preventive health care, 10 Antidepressant medications, 303 neuroreceptor effects of, 284t non-SSRI, 304, 305 Antipsychotic medications, 294–295, 307 atypical doses/formulations for, 308t monitoring recommendations for, 308t risks of, 308t

Antiretroviral therapy associated toxicity of, 224t for HIV, 224, 222 initiation recommendations for, 224t Anxiety disorders, 297 CBT for, 301 definitions of, 297 epidemiology of, 299 evaluation of, 300 genetics and, 300 major points of, 302 management of, 301 neurochemistry and, 300 neuroimaging and, 300 outcome for, 301 pathophysiology of, 300 psychological perspectives on, 300 screening tools for, 301 SSRIs for, 301 Aphthous ulcers, on vulva, 191, 192f Aripiprazole (Abilify), 289, 307 ASCCP. See American Society for Colposcopy and ­Cervical Pathology ASC-US. See Atypical squamous cells of undetermined significance Asexual, 135 Aspart, 85t Assembly, of HIV, 222 Association of Retarded Citizens, 35 Atazanavir, 224t Atenolol, 79t, 108t Atherosclerosis, risk factors effects on, 93f Athletes, nutrition for, 24 Ativan, effects of, 272t Atomoxetine (Strattera), 260t, 311 Atorvastatin, 94t Atovaquone, 226t Attention-deficit/hyperactivity disorder (ADHD), 112, 257 adulthood healthcare transition for, 262 associated conditions with, 258, 259t behavioral therapy for, 261 diagnosis of, 257 diagnostic criteria for, 257, 258 limitations of, 258 dimensions/behaviors of, 258t dosing information for, 260t epidemiology of, 257 evaluation of, 259 major points on, 262 management of, 259 outcome for, 262 school and, 261 second tier medications for, 261 social adaption and, 261



Attention-deficit/hyperactivity disorder (Continued) stimulant medications for, 260 treatment adherence for, 261 Atypical squamous cells of undetermined significance (ASC-US), 206, 208 Auditory hallucinations, 292 Axillary acanthosis nigricans, 169f Azelaic acid, 100t Azithromycin, 101t, 226t AZT. See Zidovudine B Back disorders, 117 convexity direction in, 117t major points of, 129 Back pain, 120 differential diagnosis for, 122 Bacterial infections, of HIV, 225 Bacterial vaginosis, 184, 187 Ansel criteria for, 187 diagnostic test characteristics for, 186t epidemiology of, 187 evaluation of, 188 management of, 188 Nugent gram stain criteria for, 188t pathophysiology of, 187 Bariatric surgery, for obesity, 69 Barrier contraception, 229 Basilar-type migraine, 104 BEARS mnemonic, for sleep assessment, 112 Behavior modification, for obesity, 68 Behavioral change counseling for, 11 motivational interviewing for, 11 trans-theoretical model of, 11 Behavioral screening, for preventive health care, 10 Behavioral therapy, for ADHD, 261 Behavioral transmission, of HIV, 220 Behçet disease, 191 The Belmont Report, 50 Benazepril, 79t Benign paroxysmal vertigo, 105 Benzodiazepines, 301 effects of, 272t Benzoyl peroxide, 100t Beta blockers, 301 for hypertension, 78, 79t Bethesda system classification, of cervical cytology, 204t Bezafibrate, 94t Bichloracetic acid, 207t Binge drinking, 269 Binge eating disorder, proposed diagnostic criteria for, 279

Index 315

Bipolar disorders (BPD), 286 diagnostic criteria for, 286 epidemiology of, 286 evaluation of, 287 outcome for, 289 pathophysiology of, 287 summary of, 289 treatment for, 288 type I, 286 diagnostic criteria for, 286, 287 type II, 286 diagnostic criteria for, 287 with unipolar depression, risk factors for, 288 Bisexual, 135 Bisexual youth, special considerations for, 138 Bisoprolol/HCTZ, 79t Blood pressure cuff bladders, recommended dimensions of, 77t Blood pressure levels female average systolic/diastolic, 75t male average systolic/diastolic, 74t measurement of, 76 Blue dot sign, of torsion of testicular appendages, 142f BMI. See Body mass index Body height, nutrition and, 20–21 Body image, nutrition and, 19 Body mass index (BMI), 14, 65 nutrition and, 21 Body weight healthy, 65 nutrition and, 20 BPD. See Bipolar disorders Breast architecture, normal, 146 Breast augmentation, 150 Breast cancer, 148 Breast development, conditions associated with, 147 Breast disorders evaluation of, 148, 149f in females, 146 pathophysiology of, 146 major points of, 151 management of, 149 Breast mass, 147, 148t Breast self-examination, 150 Bright Futures, 9–10 Bulimia nervosa, 279 definition of, 279 diagnostic criteria for, 279 epidemiology of, 279 evaluation of, 279 management of, 280 pathophysiology of, 279 Bupropion (Wellbutrin), 284t, 285, 289, 305 Buspirone, 301

316 Index

C CAH. See Congenital adrenal hyperplasia Calcium, 23 content in food, 23t Calcium carbonate, for PMS, 163 Calcium channel blockers, for hypertension, 78 Candida albicans, 185 Candida glabrata, 185 Candidiasis, 185 diagnostic test characteristics for, 186t epidemiology of, 185 evaluation of, 185 HIV and, 225–226 major points of, 192 management of, 185–186 pathophysiology of, 185 wet mount of, 186f Captopril, 79t Carbamazepine, 310 Cardiovascular benefits, of exercise/sports, 14 Cardiovascular disease (CVD), 72 PCOS and, 169 Cardiovascular mortality rates, with oral contraception, 234f CBT. See Cognitive behavioral therapy CD. See Conduct disorder CDRS-R. See Children’s Depression Rating Scale-Revised Cefixime, 196 Ceftriaxone, 196 Center for Adolescent Health and the Law, 46 Centers for Disease Control and Prevention (CDC) exercise recommendations of, 14 physical activity recommendations by, 16 Cervical cancer, screening for, 206 Cervical cytology by age, 205f Bethesda system classification of, 204t Cervical dysplasia, 202 Cervical ectopy, 194, 202 Cervicitis, 194 Chancroid, 217 epidemiology of, 217 evaluation of, 218 management of, 218 pathophysiology of, 217 reported cases of, 217f treatment guidelines for, 218t CHD. See Coronary heart disease Childhood periodic syndromes, 105 Children’s Depression Rating Scale-Revised (CDRS-R), 285 Chlamydia, 197 diagnosis of, 198 epidemiology of, 197

Chlamydia (Continued) management of, 198 pathophysiology of, 197 screening tests for, 9, 196t treatment of, 198 Chlamydia trachomatis, 194, 197 Chloracne, 98 Chlorthalidone, 79t Cholesterol levels, for morbid obesity, 70t Cholestyramine, 94t Cholinergic antagonist, 284t Chromosomal sex, 135 Chronic health conditions, 34 advocacy and, 35 community resources for, 28 growth/development monitoring and, 35 immunizations and, 36 medical home and, 34 model health care system for, 34 primary care provider for, 34, 35 risk assessment and, 35 self-management factors for, 36 sexual/reproductive health care and, 36 Chronic pelvic pain, 175 Ciprofloxacin, 196 Circadian rhythm treatment, for DSPS, 113, 114f Citalopram (Celexa), 163, 304 Clarithromycin, 226t Clindamycin, 100t Clinical consent forms, 45 Clinician role/responsibility, adolescent participation in research, 49 Clofibrate, 94t Clomipramine, 301 Clonidine, 79t, 301, 310–311 Clozapine (Clozaril), 294–295, 307–308 COBRA. See Consolidated Omnibus Budget ­Reconciliation Act Cocaine, effects of, 272t Codeine, effects of, 272t Cognitive behavioral therapy (CBT), 285 for anxiety disorders, 301 Cognitive development, 3 Cognitive maturity, 31 Colesevelam, 94t Colestipol, 94t Community resources, for chronic health conditions, 28, 29 Compensation, adolescent participation in research and, 49, 50 Compulsions, 298 Concerta, 260t Conduct disorder (CD), 264 definition of, 264–265 diagnostic criteria for, 265

Index 317



Conduct disorder (Continued) epidemiology of, 265 evaluation of, 266 major points of, 267 management of, 266 MST for, 266 outcome of, 266 pathophysiology of, 265 PMT for, 266 PSST for, 266 Confidentiality, 44, 46 adolescent participation in research and, 49 Confusional migraine, 105 Congenital adrenal hyperplasia (CAH), 77 late-onset, 165 Consolidated Omnibus Budget Reconciliation Act (COBRA), 41 Contraception, 230 barrier, 228 effectiveness of, 232t emergency, 228 estrogens as, 228 evaluation for, 231 hormonal, 228 at last intercourse, 230f major points of, 242 mechanisms of action of, 230 medical conditions for, 231 medical eligibility for, 231 methods of, 242t oral cardiovascular mortality rates with, 234f drugs reducing effectiveness of, 232 family history and, 232 menstrual history and, 232 physical examination and, 232 precluding medical conditions for, 231t social/sexual history and, 232 permanent, 228–229 progestins as, 229 reversible, 229 spermicides as, 229 use at time of first intercourse, 230f use by sexually active adolescents, 230f Cool cognition, 3 Coronary heart disease (CHD), obesity and, 66 Corpus luteum cyst, 175 CRAFFT screening test, for substance abuse, 273 Crohn disease, 191, 192f Cruciate ligament insufficiency, meniscal injury and, 129 Cutaneous HPV, 202 CVD. See Cardiovascular disease Cyclical vomiting syndrome, 105 Cyclothymic disorder, 286

CYP-450 effects, of SSRIs, 306t Cyproheptadine, 108t D D4T. See Stavudine Dapsone, 226t Dawn effects, 85 DCCT. See Diabetes Control and Complications Trial DD. See Developmental disabilities DDC. See Zalcitabine DDI. See Didanosine DDNOS. See Depressive disorder not otherwise ­specified Delavirdine, 224t Delayed sleep phase syndrome (DSPS), 110, 113 circadian rhythm treatment for, 113, 114f Delusions, 292 Dependence, 269 Depo-Provera, 163 Depression causes of, 284–285 evaluation of, 284 pathophysiology of, 282 presentation of, 284 risk factors for, 284 symptoms of, 285 Depressive disorder not otherwise specified (DDNOS), 282 Depressive disorders, 282. See also specific depressive disorders outcome for, 289 pathophysiology of, 282 treatment for, 285 Dermoid cyst, 175 Detemir, 85t Developmental disabilities (DD), 247–248 adaptive equipment for, 252 adolescent autonomy and, 252 common conditions of adolescents with, 252 epidemiology of, 248 evaluation of, 249 guardianship and, 254 health insurance and, 253 IEP and, 253 immunizations and, 252 living options for, 255t major points of, 255 management of, 251 medical home for, 251 multifactored evaluation of, 250, 251 outcome for, 255 pathophysiology of, 249 psychosexual counseling and, 253 school and, 253 self-determination options and, 254

318 Index

Dexamethasone, 102t Dexedrine Spansule, 260t Dexedrine/Dextrostat, 260t Dextroamphetamine, 260t mixed amphetamine salts and, 307t Dextromethylphenidate, 260t DHE. See Dihydroergotamine Diabetes Control and Complications Trial (DCCT), 84–85 Diabetes mellitus (DM), 82. See also Type 1 diabetes mellitus;Type 2 diabetes mellitus ADA definition of, 84t diagnosis for, 83 epidemiology of, 82 evaluation of, 83 hygiene hypothesis of, 83 macrovascular complications of, 82 macrovascular disease and, 87 major points on, 89 management issues with, 86 microvascular complications of, 82 microvascular disease and, 87 outcomes for, 87 outpatient evaluation of, 85 pathophysiology of, 83 pre-, ADA definition of, 84t Diabetic ketoacidosis (DKA), 82 Didanosine (DDI), 224t Dietary experimentation, 19 Dihydroergotamine (DHE), 106t Dimenhydrinate, 106t DKA. See Diabetic ketoacidosis DM. See Diabetes mellitus Dopamine uptake inhibitors, 284t Doxazosin, 79t Doxycycline, 101t, 196 Driving,T1DM and, 87 Drospirenone, 163 Drug use, 269. See also Substance use MTF trends in, 270 Drug/alcohol usage, sexual intercourse and, by high school grade, 137f DSPS. See Delayed sleep phase syndrome Dual diagnosis, 269 DUB. See Dysfunctional uterine bleeding Ductal ectasia, 147 Duloxetine (Cymbalta), 305 Dysfunctional uterine bleeding (DUB), 157 anovulatory, 158 differential diagnosis of, 157 epidemiology of, 157 evaluation of, 158 management of, 158, 159 pathophysiology of, 158 pregnancy and, 158 von Willebrand disease and, 158

Dyslipidemia, 90 pharmacotherapy for, 94t statin therapy for, 95f Dysmenorrhea, 160 evaluation of, 160 management of, 161 NSAID regimens for, 161t pathophysiology of, 160 primary, 160 secondary, 160 Dyssomnias, 110 Dysthymic disorder, diagnostic criteria for, 283 E Eating disorders, 276 major points of, 280 T1DM and, 86–87 Ectropion, 194 Education/counseling, for PCOS, 172 Efavirenz, 224t Emancipated minor, 44 Emergency contraception, 228 Emtricitabine (FTC), 224t Enalapril, 79t Endometrial cancer, PCOS and, 169 Endometrioma, 175 Endometriosis, 175–176, 178 epidemiology of, 178 evaluation of, 179 intraoperative view of, 179f management of, 179 pathophysiology of, 178 Endometritis, 194 Energy, nutrition and, 23 Environmental factors, PCOS and, 167 Epididymitis, 141 epidemiology of, 141 evaluation of, 142 management of, 142 pathophysiology of, 141 vs. testicular torsion, 141t Erythromycin, 100t, 101t Escitalopram (Lexapro), 163, 304 Estrogen/progestin therapy, for PCOS, 171 Estrogens, as contraception, 229 Estrostep, 102t Ethical principles, in adolescent participation in ­research, 49, 51 Ethinyl estradiol, 163 Eunuchoidal habitus, 59 Exercise/sports cardiovascular benefits of, 14 definitions for, 14 epidemiology of, 15 health benefits of, 14

Index 319



Exercise/sports (Continued) injury prevention in, 17 introduction to, 14 mental health benefits of, 15 musculoskeletal benefits of, 15 PPE and, 17 return to play and, 17 Expected adult height, 59 Extreme daytime sleepiness, 110 Ezetimibe, 94t F Fallopian tubes, congenital anomalies of, 180 Familial combined hyperlipidemia (FCH), 90–91 Familial hemiplegic migraine, 104 Familial hypercholesterolemia (FH), 90 Family Voices, 35 Fasting plasma glucose (FPG), 83–84 Felodipine, 79t Fenofibrate, 94t Ferriman-Gallwey system, of hirsutism, 168t, 169f FH. See Familial hypercholesterolemia FHH. See Functional hypogonadotropic hypogonadism Fibroadenoma, 146 Fitness, 14 Fitz-Hugh-Curtis syndrome, 194 Fluorescent treponemal antibody absorbed (FTA-ABS), 216 Fluoxetine (Prozac), 163, 304 Flutamide, 102t Fluvastatin, 94t Fluvoxamine (Luvox), 304–305 Focalin, 260t Focalin XR 7, 260t Follicular cyst, 176 Food guide pyramid, 23 Fosamprenavir, 224t Fosinopril, 79t FPG. See Fasting plasma glucose FRAMES interviewing mnemonic, 274t FTA-ABS. See Fluorescent treponemal antibody absorbed FTC. See Emtricitabine Function, WHO classification of, 249f Functional hypogonadotropic hypogonadism (FHH), 61 causes of, 61 Furosemide, 79t Fusion and entry, of HIV, 221 G GAD. See Generalized anxiety disorder Galactorrhea, 146 conditions associated with, 148t Gamma-hydroxybutyrate (GHB), effects of, 272t GAPS. See Guidelines for Adolescent Preventive Services Gardnerella vaginalis, 187

Gatifloxacin, 196 Gemfibrozil, 94t Gender, 135 Gender identity, 135 Gender identity dysphoria, 136 Gender role, 135 Generalized anxiety disorder (GAD), 298 diagnostic criteria for, 299 Genetics anxiety disorders and, 300 PCOS and, 167 Genital herpes, 211 epidemiology of, 211 evaluation of, 213 management of, 214 physicians’ office visits, 212f primary, 212–213 recurrent, 213 treatment for, 214t Genital infection, of HPV, prevalence of, 204f Genital ulcer disease (GUD), 211 Genital warts, 204f patient-applied treatment of, 207t provider-applied treatment of, 207t treatment for, 206 GHB. See Gamma-hydroxybutyrate Glargine, 85t Glucose levels, for morbid obesity, 70t GnRH. See Gonadotropin-releasing hormone Gonadotropin abnormalities, PCOS and, 166 Gonadotropin-releasing hormone (GnRH), 4 Gonadotropins, 165 Gonococcal infections disseminated, CDC recommendations for, 197 of pharynx, CDC recommendations for, 197 Gonorrhea, 194 clinical evidence of, 195 diagnosis of, 195 epidemiology of, 194 management of, 196 pathogenesis of, 195 screening tests for, 196t Guanfacine, 310–311 Guardianship, DD and, 254 GUD. See Genital ulcer disease Guidelines for Adolescent Preventive Services (GAPS), 68, 118 Gynecomastia, during puberty, 7 H Haemophilus ducreyi, 215, 217 Haemophilus vaginalis, 187 Haloperidol, 294–295 Harris-Benedict Equation, for resting energy ­expenditure, 23t

320 Index

Hatch Amendment, 50 Headaches, 105. See also Migraine abortive therapy for, 106–107, 106t diagnostic criteria for, 104 epidemiology of, 105 evaluation of, 106 general measures for, 106 major points on, 109 management of, 106 NSAIDs for, 107 outcomes for, 108 pathophysiology of, 105 primary vs. secondary, 104 prophylactic therapy for, 107, 108t Health care, for LGBTQ youth, 138 Health insurance DD and, 253 transition to, adult health care and, 40 Health Insurance Portability and Accountability Act (HIPAA), 44 Healthy People 2010 objectives, physical activity ­recommendations by, 16 Healthy weight, 65 HEEADSSS mnemonic, 137 Hemi-syndrome migraine, 105 Hernias anatomy of, 143f inguinal, 142, 143f Herpes simplex virus (HSV), 211 Herpes simplex virus type 1 (HSV-1), 211 Herpes simplex virus type 2 (HSV-2), 211 Heterosexual, 135 HHANES. See Hispanic Health and Nutrition ­Examination Surveys Hidradenitis suppurativa, 190–191, 191f High-grade squamous intraepithelial lesion (HSIL), 208 High-risk HPV, 202 Hip disorders, 120 major points of, 129 stress fracture and, 124, 124f HIPAA. See Health Insurance Portability and ­Accountability Act Hirsutism, 165 Ferriman-Gallwey system for, 168t, 169f idiopathic, 165 Hispanic Health and Nutrition Examination Surveys (HHANES), 4 HIV. See Human immunodeficiency virus Homosexual, 135 experience, 136 Homosexual youth, special considerations for, 138 Hormonal contraception, 228 Hormonal therapy for menstrual disorders, 156 for puberty delay, 63

Hot cognition, 3 HPV. See Human papillomavirus HSIL. See High-grade squamous intraepithelial lesion HSV. See Herpes simplex virus HSV-1. See Herpes simplex virus type 1 HSV-2. See Herpes simplex virus type 2 Human immunodeficiency virus (HIV), 220–221 acute infection, 222 antiretroviral therapy for, 223, 224t assembly of, 222 bacterial infections of, 224 behavioral transmission of, 220 candidiasis and, 225–226 epidemiology of, 221 evaluation of, 222 fusion and entry of, 221 health maintenance for, 223 integration and translation of, 221 life cycle of, 221 major points of, 226 management of, 223 newly diagnosed, 222 NPEP and, 226 opportunistic infections of, 221, 224 outcome of, 226 partner notification of, 221 pathophysiology of, 221 pneumonia and, 224–225 postexposure prophylaxis for, 221 potential exposure to, 223 primary infection of, 220 reverse transcription of, 221 risk behaviors of, 221 secondary infection and, 226 seroconversion syndrome, acute, 220 testing for, 223 viral protein formation of, 221–222 VZV and, 226 Human papillomavirus (HPV), 202 anogenital warts and, 205 classification of, 203f cutaneous, 202 epidemiology, 203 evaluation of, 205 genital infection prevalence of, 204f high-risk, 202 low-risk, 202 major points of, 209, 218 management of, 207 mucosal, 202 pathophysiology of, 203 patient education on, 209 risk factors for, 205 vaccines for, 208 Hydralazine, 79t



Hydrocele, 140, 142 Hydrochlorothiazide, 79t Hydrocodone, effects of, 272t Hygiene hypothesis, of DM, 83 Hymen imperforate, 155 normal/variant anatomy of, 190f Hyperandrogenism, 155 during puberty, 6–7 Hypercholesterolemia causes of, 91t step-one/step-two diets for, 93t Hyperlipidemia, 90 diet/behavior changes for, 92 evaluation for, 91 major points on, 95 management of, 91 outcomes for, 94 pathophysiology of, 90 pharmacotherapy for, 92 risk categories for, 92t screening for, 91 Hyperprolactinemia, conditions associated with, 148t Hypertension, 72 age/height chart for, 73f beta blockers for, 78, 79t calcium channel blockers for, 78 epidemiology of, 73 evaluation of, 76 history of, 77 laboratory studies for, 77 major points on, 80 management of, 77 medications for, 79t nonpharmacological therapy for, 77 pathophysiology of, 73 pharmacotherapy for, 78 physical examination for, 77 pre-, 72–73, 76t stage 1, 72–73, 76t stage 2, 72–73, 76t causes of, 76t treatment algorithm for, 78f white-coat, 73 Hypoglycemia, 85 Hypogonadism primary, 59 secondary, 59 Hypogonadotropic hypogonadism, 59, 60 Hypothalamic causes, of amenorrhea, 153 I Ibuprofen, 106t IDEA. See Individuals with Disabilities Education Act IEP. See Individualized Educational Plan

Index 321

IGFBP-1. See Insulin-like growth factor binding protein-1 Iliotibial band syndrome, 129 Imaginary audience, 3 Imiquimod, 207t Immunizations, 9 chronic health conditions and, 36 DD and, 252 preventive health care and, 10 recommended schedule for, 11f Imperforate hymen, 155 Indinavir, 224t Individualized Educational Plan (IEP), 35 adult health care, transition to, 40 DD and, 253 diagnostic categories for, 254 Individuals with Disabilities Education Act (IDEA), 35 adult health care, transition to, 40 Infertility, PCOS and, 169 Informed consent, 44, 45 adolescent participation in research and, 49 elements of, 51 federal regulations on, 50, 51 Inguinal hernia, 142, 143f Injury prevention, in exercise/sports, 17 Insomnia, 110 Institute of Medicine parental guideline recommendations, for adolescent participation in research, 50–51, 53 Institutional Review Board (IRB), 50, 51, 53 Insulin for morbid obesity, 70t preparations, 85t resistance, 82 PCOS and, 168 total daily dose of, 84–85, 86t use of, 84 Insulin-like growth factor binding protein-1 (IGFBP-1), 153 Insulin-sensitizing agents, for PCOS, 172 Integration/translation, of HIV, 221 Intellectual function, 248 Intelligence quotient (IQ), 248 International Classification of Sleep Disorders 2nd ­Edition, 112–113 Internet resources, for adolescent self-care readiness, 253 Interpersonal psychotherapy (IPT), 285 Intoxication, 269 IPT. See Interpersonal psychotherapy IQ. See Intelligence quotient IRB. See Institutional Review Board Irbesartan, 79t Iron, 23 Isotretinoin, 100t Isradipine, 79t

322 Index

J Judicial bypass, 44 Juvenile Diabetes Research Foundation, 35 K Ketamine, effects of, 272t Ketoralac, 106t Knee dislocation, 117–118 Knee pain acute, 126 chronic, 127 major points of, 129 muscle strain/tear and, 127 Kyphosis, 119 Scheuermann, 119 L Labetalol, 79t Labia, normal symmetry of, 190f Lamotrigine (Lamictal), 310 Latent syphilis, 215 Lateral patellar fracture, 126f Legg-Calvé-Perthes disease, 123 Leiomyoma, 176 Lesbian, gay, bisexual, transsexual, or questioning (LGBTQ) youth, 136–137 health care for, 138 Leucovorin, 226t Leukorrhea, 184 Leuprolide, 102t Levofloxacin, 196 LGBTQ youth. See Lesbian, gay, bisexual, transsexual, or questioning youth LHRH. See Luteinizing hormone-releasing hormone Librium, effects of, 272t Lifestyle changes for PCOS, 172 for T2DM, 86 Lifetime sexual partners, by high school grade, 137f Lipid screening, selective, 91f Lisinopril, 79t Lispro, 85t Lithium carbonate, 309 Lobule, 146 Lomefloxacin, 196 Losartan, 79t Lovastatin, 94t Low self-esteem. See also Self-esteem PCOS and, 169 Lower abdominal pain, female pelvic disorders and, 176 Low-grade squamous intraepithelial lesion (LSIL), 208 Low-risk HPV, 202 LSD. See Lysergic acid diethylamide LSIL. See Low-grade squamous intraepithelial lesion

Luteinizing hormone-releasing hormone (LHRH), 4 Lysergic acid diethylamide (LSD), effects of, 272t M MAC. See Mycobacterium avium complex Macromastia, 146 Macrovascular complications, of DM, 82 Macrovascular disease, DM and, 87 Major depressive disorder (MDD), 282 diagnostic criteria for, 283 epidemiology of, 282 outcome for, 289 Mammoplasty reduction, 150 Mania, symptoms of, 287–288 Marijuana, effects of, 272t Mastalgia, 146, 147 management of, 147 Mastitis, 146 Mastodynia, 146 Mature minor doctrine, 44 Maturity-onset diabetes of youth (MODY), 82 MCL. See Medial collateral ligament MDD. See Major depressive disorder MDMA. See 3,4 methylenedioxymethamphetamine Meal pattern/composition, 19 Medial collateral ligament (MCL), sprain/tear, 126 Medial patellar contusion, 127f Medical home chronic health conditions and, 34 for DD, 251 Meniscal injury, cruciate ligament insufficiency and, 129 Meniscal tear, 126–127 Menstrual cycle, normal, 152 Menstrual disorders, 152 evaluation of, 155 hormonal therapy for, 156 major points of, 164 management of, 156 outflow tract anomalies of, 154–155 pathophysiology of, 153 Menstrual migraine, 105 Menstrual molimina, 228 Mental health benefits, of exercise/sports, 15 Mental retardation (MR), 247, 248 causes of, 249t epidemiology of, 248 evaluation of, 249 major points of, 255 pathophysiology of, 249 unexplained evaluation of, 250 genetic testing for, 250 neuroimaging for, 250 Mental status examination, 285t



Mescaline, effects of, 272t Metabolic abnormalities, PCOS and, 166 Metabolic syndrome, 165 PCOS and, diagnostic criteria for, 170 Metadate CD, 260t Methamphetamine, effects of, 272t 3,4 methylenedioxymethamphetamine (MDMA), effects of, 272t Methylin, 260t Methylin ER, 260t Methylphenidate, 260t Methylphenidate formulations, 306t Metoclopramide, 106t Metoprolol, 79t Microvascular complications, of DM, 82 Microvascular disease, DM and, 87 Midrin, 106t Migraine, 104. See also Headaches abdominal, 105 abortive therapy for, 106–107 without aura, 104 basilar-type, 104 confusional, 105 diagnosis of, 105 familial hemiplegic, 104 hemi-syndrome, 105 menstrual, 105 ophthalmoplegic, 105 with prolonged aura, 104–105 sporadic hemiplegic, 104 with typical aura, 104 variants of, 105 Migrainous infarction, 104–105 Minerals, 23 Minocycline, 101t Minors, 44 rights of, 44 Minoxidil, 79t Mirtazapine (Remeron), 284t, 305 Mixed amphetamine salts, dextroamphetamine and, 307t Modafinil (Sparlon), 311 Model health care system, for chronic health conditions, 34 MODY. See Maturity-onset diabetes of youth Monitoring the Future (MTF), 269 Mood disorders, 282 Mood stabilizers, 308 doses/formulations for, 309t half-lives of, 309t monitoring of, 309t serious side effects of, 310t serum levels of, 309t Morbid obesity, 65 cholesterol levels for, 70t

Index 323

Morbid obesity (Continued) glucose levels for, 70t insulin levels for, 70t triglycerides levels for, 70t Morgagni tubercles, 146 Motivational interviewing for behavioral change, 11 principles of, 274t MR. See Mental retardation MST. See Multi-systemic therapy MTF. See Monitoring the Future Mucosal HPV, 202 Müllerian anomalies, 180 epidemiology of, 180 management of, 181 pathophysiology of, 180 Müllerian ducts, 176 Multi-systemic therapy (MST) for CD, 266 ODD for, 266 Muscle strain/tear, knee pain and, 127 Musculoskeletal benefits, of exercise/sports, 15 Musculoskeletal complaints, during puberty, 7 Musculoskeletal injury, rehabilitation phases after, 17t Mycobacterium avium complex (MAC), 224, 225t Myopia, during puberty, 7 N NAFLD. See Non-alcoholic fatty liver disease Naproxen, 106t Narcolepsy, 110 National Cholesterol Education Program (NCEP), 91 National Health Examination Surveys (NHES), 4 National High Blood Pressure Education Program ­Working Group (NHBPEP IV), 72 National Survey on Drug Use and Health (NSDUH), 269–270 NCEP. See National Cholesterol Education Program Nefazodone (Serzone), 305 Neisseria gonorrhoeae, 194 laboratory tests for, 196t Nelfinavir, 224t Neurochemistry, anxiety disorders and, 300 Neuroimaging, anxiety disorders and, 300 Neutral protamine Hagedorn (NPH), 84 Nevirapine, 224t NHBPEP IV. See National High Blood Pressure Education Program Working Group NHES. See National Health Examination Surveys Niaspan, 94t Nifedipine extended release, 79t Nipple discharge, 147 No Child Left Behind Act, 50 Non-alcoholic fatty liver disease (NAFLD), obesity and, 66–67

324 Index

Nonoccupational postexposure prophylaxis (NPEP), HIV and, 226 Non-rapid eye movement (NREM) sleep, 110 Non-SSRI antidepressants, 305, 306t Non-steroidal anti-inflammatory drugs (NSAIDs) for dysmenorrhea, 161t for headaches, 107 Norepinephrine reuptake inhibitors, 284t Norfloxacin, 196 Normal growth/development, 3 Nortriptyline, 108t NPEP. See Nonoccupational postexposure prophylaxis NPH. See Neutral protamine Hagedorn NREM sleep. See Non-rapid eye movement sleep NSAIDs. See Non-steroidal anti-inflammatory drugs NSDUH. See National Survey on Drug Use and Health Nugent gram stain criteria, for bacterial vaginosis, 188t Nutrition for athletes, 24 BMI and, 21 body height and, 20–21 body image and, 19 body weight and, 20 deficiency, 21t energy and, 23 growth/development and, 19 history and, 20 label, 25f laboratory evaluation, 22 meal pattern/composition and, 19 physical examination and, 20 during pregnancy, 25 skin fold measurement and, 21–22 waist circumference and, 21 waist-hip ratio and, 21 Nutritional assessment, 19 Nutritional counseling, 23 Nutritional requirements, 22 definitions of, 22 Nutritional supplementation, 23 O Obesity, 65 bariatric surgery for, 69 behavior modification for, 68 CHD and, 66 complications of, 66, 67f definitions for, 65 epidemiology of, 65 evaluation of, 68 major points on, 70 management of, 68 morbid, 65

Obesity (Continued) NAFLD and, 66–67 natural history of, 65 pharmacotherapy for, 68 pseudotumor cerebri and, 67 psychosocial development and, 67–68 sleep-disordered breathing and, 66 T2DM and, 66 Objective cognition, 3 Obsessions, 298 Obsessive-compulsive disorder (OCD), 298 Obstructive sleep apnea (OSA), 114 OCD. See Obsessive-compulsive disorder OCPs. See Oral contraceptive pills ODD. See Oppositional defiant disorder Office for Human Research Protection (OHRP), 53 Office systems, for preventive health care, 11, 12 Ofloxacin, 196 OGTT. See Oral glucose tolerance test Olanzapine (Zyprexa), 294–295, 307 Omacor, 94t Ophthalmoplegic migraine, 105 Opportunistic infections of HIV, 22, 221 prophylaxis against, 226t Oppositional defiant disorder (ODD), 264 definition of, 264 diagnostic criteria for, 264 epidemiology of, 265 evaluation of, 266 major points of, 267 management of, 266 MST for, 266 outcome of, 266 pathophysiology of, 265 PMT for, 266 PSST for, 266 Oral contraceptive pills (OCPs) for PCOS, 171–172 for PMS, 163 Oral glucose tolerance test (OGTT), 83–84 Oral isotretinoin, for acne, 99 Oral pharmacotherapy, for T2DM, 86 Orthotricyclen, 102t OSA. See Obstructive sleep apnea Osgood-Schlatter disease, 128, 128f Osteochondritis dissecans, 129, 130f Outflow tract anomalies, of menstrual disorders, 154 Ovarian blood supply, torsed, 176f Ovarian causes, of amenorrhea, 154 Ovarian cyst functional, 177 epidemiology of, 177 evaluation of, 178 management of, 178



Ovarian cyst (Continued) pathophysiology of, 177 left, 178f surgical removal of, 181f Ovarian tumors, 181 epidemiology of, 181 evaluation of, 182 management of, 182 pathophysiology of, 181 serum tumor markers for, 182t Ovarian/adrenal steroid abnormalities, PCOS and, 166 Overweight, 65 Oxycodone, effects of, 272t P Panic, 297 symptoms of, 298 Panic attacks, 297, 298 Panic disorder, 297 Pap test. See Papanicolaou test Papanicolaou (Pap) test, 202 Parasomnias, 110 Parental consent waiver, for adolescent participation in research, 50 Parent-management training (PMT) for CD, 266 for ODD, 266 Parent-teen conflict Paroxetine (Paxil), 163, 304 Partner notification, of HIV, 221 Patellar dislocation, 127f, 128 Patellofemoral syndrome, 127 Patient education, on HPV, 208 PCL. See Posterior cruciate ligament PCOS. See Polycystic ovary syndrome PCP. See Phencyclidine Peak height velocity (PHV), 5 in boys, 5 Pelvic apophyses, avulsion fractures of, 125 anteroposterior radiograph of, 125f bone-muscle groups in, 125t Pelvic disorders of female, 175 lower abdominal pain and, 176 major points of, 182 presentation of, 175 Pelvic inflammatory disease (PID), 176, 194, 198 diagnosis of, 199 differential diagnosis of, 199 epidemiology of, 198 hospitalization indicators for, 200 intramuscular/oral treatment of, 200 intravenous treatment of, 200 pathophysiology of, 198 treatment for, 200

Index 325

Pelvic pain acute, differential diagnosis of, 176 chronic, 175 chronic, recurrent, differential diagnosis of, 176 non-gynecological causes of, 161 Pentamidine, 226t People first language, 248 Periodic limb movement disorder (PLMD), 110, 115 Permanent contraception, 229–230 Personal fable, 3 Pharynx, gonococcal infections of, CDC recommendations for, 197 Phencyclidine (PCP), effects of, 272t Phenotypic sex, 135 PHV. See Peak height velocity Physical activity, 14 CDC recommendations for, 16 decreasing trends of, 15 Healthy People 2010 objectives recommendations for, 16 sufficient moderate, 14 sufficient vigorous, 14 Physical examination nutrition and, 20 for preventive health care, 10 PI. See Psychophysiologic insomnia PID. See Pelvic inflammatory disease Pituitary causes, of amenorrhea, 154 PLMD. See Periodic limb movement disorder PMDD. See Premenstrual dysphoric disorder syndrome PMS. See Premenstrual syndrome PMT. See Parent-management training Pneumocystis carinii, 225, 226t Pneumocystis jiroveci, 225, 226t Pneumonia, HIV and, 225 Podofilox, 207t Polycystic ovaries, 165 Polycystic ovary syndrome (PCOS), 97 antiandrogens for, 172 clinical manifestations of, 168 clinical sequelae of, 169 CVD and, 169 developmental hypotheses of, 167 diagnosis of, 170 education/counseling for, 172 endometrial cancer and, 169 environmental factors and, 167 estrogen/progestin therapy for, 171 genetics and, 167 gonadotropin abnormalities and, 166 hypothesized pathogenesis of, 167f infertility and, 169 insulin resistance and, 168 insulin-sensitizing agents for, 172 laboratory/radiographic findings of, 171, 169

326 Index

Polycystic ovary syndrome (Continued) lifestyle changes for, 172 low self-esteem and, 169 major points of, 173 management of, 171 metabolic abnormalities and, 166 metabolic syndrome and, diagnostic criteria for, 170 OCP for, 171–172 ovarian/adrenal steroid abnormalities and, 166 pathophysiology of, 166 progestin-only therapy for, 171 risk factors of, 165 Polymastia, 146 Polysomnography (PSG), 110 Polythelia, 146 Positive coping strategies, against youth violence, 30f Posterior cruciate ligament (PCL), sprain/tear, 127 Post-traumatic stress disorder (PTSD), 298 diagnostic criteria for, 299 PPE. See Pre-participation evaluation Pravastatin, 94t Prazosin, 79t Pre-diabetes, ADA definition of, 84t Prednisone, 102t Pregnancy DUB and, 158 epidemiology of, 230, 230f nutrition during, 25 T1DM and, 87 unintended increased risks to, 232 management of, 234 Premature adrenarche, 165 Premenstrual dysphoric disorder syndrome (PMDD), 162 symptoms of, 163 treatment of, 163 Premenstrual syndrome (PMS), 162 calcium carbonate for, 164 epidemiology of, 162 evaluation of, 162 OCPs for, 163 pathophysiology of, 162 symptoms of, 163 treatment of, 163 Pre-participation evaluation (PPE), exercise/sports and, 17 Preventive health care anticipatory guidance for, 10 behavioral screening for, 10 elements of, 10 immunizations and, 10 introduction to, 9 laboratory screening for, 10 office systems for, 11, 12 physical assessment for, 10

Primary care provider, for chronic health conditions, 34, 35 Primary dysmenorrhea, 160 Primary genital herpes, 212–213 Primary HIV infection, 220 Primary hypogonadism, 59 Primary syphilis, 215 Privacy, 46 Problem-solving skills training (PSST) for CD, 266 for ODD, 266 Processus vaginalis, 140 Progestin-only therapy, for PCOS, 171 Progestins, as contraception, 230 Promethazine, 106t Propionibacterium acnes, 97–98 Propranolol, 79t, 108t Pseudotumor cerebri, obesity and, 67 PSG. See Polysomnography Psilocybin, effects of, 272t PSST. See Problem-solving skills training Psychiatric pharmacotherapy, 303 Psychological perspectives, on anxiety disorders, 300 Psychophysiologic insomnia (PI), 113 diagnostic criteria for, 113 Psychosexual counseling, DD and, 253 Psychosexual identity, 3 Psychosocial development, obesity and, 67–68 Psychostimulants, 305 Psychotic disorders, 291 definition of, 291 epidemiology of, 292 evaluation of, 292, 293 heritability in, 292 historical perspective on, 291 major points of, 296 neurological findings on, 292 pathophysiology of, 292 presentation of, 292 PTSD. See Post-traumatic stress disorder Pubarche, 165 Pubertal events sequence for boys, 7f sequence for girls, 7f Pubertal stage, testicular volume by, 6f Puberty acne during, 6–7 growth curves of, 5f gynecomastia during, 7 hyperandrogenism during, 6–7 musculoskeletal complaints during, 7 myopia during, 7 onset/timing of, 4 problems during, 5

Index 327



Puberty delay, 59 causes of, 60 constitutional, 59, 60 definition of, 59 epidemiology of, 60 evaluation of, 62 hormonal therapy for, 63 laboratory/radiographic evaluation of, 62 major points of, 63 management of, 63 pathophysiology of, 60 Pubic hair development in boys, 6f in girls, 6f Pyelonephritis, 184 Pyrimethamine, 226t Pyuria, 184 Q Quetiapine (Seroquel), 307 Quinapril, 79t R Ramelteon (Rozerem), 311 Rapid eye movement (REM) sleep, 110–111 Rapid Plasma Reagin (RPR), 216 RDAs. See Recommended Dietary Allowances Readiness for change, youth violence and, 31 Recommended Dietary Allowances (RDAs), 22t Recovery, 269 Recurrent genital herpes, 213 Recurrent respiratory papillomatosis (RRP), 202 Refeeding syndrome, anorexia nervosa and, 277–278 Regulations/guidelines, for adolescent participation in research, 50 Relapse, 269 REM sleep. See Rapid eye movement sleep Reproductive outflow tract anomalies, evaluation of, 180 Research, adolescent participation in, 48 challenges of, 48 clinician role/responsibility in, 49 compensation and, 49, 50 confidentiality and, 49 developmental maturity and, 48 ethical principles in, 49, 51 guidelines in, 50, 53 importance of, 48 informed consent and, 49 Institute of Medicine parental guideline ­recommendations for, 50–51, 53 major points on, 54 oversight of, 53 parental consent waiver for, 50 regulations/guidelines for, 50

Research, adolescent participation (Continued) risk level in, 50 in schools, 50 Resilience-based prevention, for youth violence, 28 Resting energy expenditure, Harris-Benedict Equation for, 23t Restless legs syndrome (RLS), 110–111, 115 Retroviral syndrome, acute, 220 Return to play, exercise/sports and, 17 Reverse transcription, of HIV, 221 Reversible contraception, 230 Reversion, 3 Risk assessment, chronic health conditions and, 35 Risk factors for self-management problems, 36–37, 37t for youth violence, 29 Risperidone (Risperdal), 294–295, 307 Ritalin, 260t Ritalin LA, 260t Ritalin SR, 260t Ritonavir, 224t RLS. See Restless legs syndrome Rohypnol, effects of, 272t Rosacea fulminans, 98 Rosuvastatin, 94t RPR. See Rapid Plasma Reagin RRP. See Recurrent respiratory papillomatosis S SAD. See Separation anxiety disorder Salpingitis, 194 Saquinavir, 224t SCFE. See Slipped capital femoral epiphysis Scheuermann kyphosis, 119 Schizophrenia, 291 diagnostic criteria for, 295 differential diagnosis of, 293, 294 epidemiology of, 292 outcome for, 295 treatment of, 294 School ADHD and, 261 DD and, 253 Scoliosis, 117 forward bend test for, 118 idiopathic, 118 management of, 118 physical examination of, 118, 118f radiograph of, 119f screening for, 118 Scrotal disorders, 140 major points of, 145 Scrotal swelling epidemiology of, 142 evaluation of, 143

328 Index

Scrotal swelling (Continued) management of, 143 pathophysiology of, 142 Secondary dysmenorrhea, 160 Secondary hypogonadism, 59 Secondary sexual characteristics, 59 Secondary syphilis, 215 Self-determination options, DD and, 254 Self-esteem, 3. See also Low self-esteem Self-management factors, for chronic health conditions, 36 Self-management problems, risk factors for, 36–37, 37t Separation anxiety disorder (SAD), 298 diagnostic criteria for, 299 Serotonin reuptake inhibitors (SSRIs), 284t, 285, 304 for anxiety disorders, 301 CYP-450 effects of, 306t dosing for, 304t drug interactions with, 306t general recommendations on, 305 half-lives, 306t Serous and mucinous cystadenomas, 176 Sertraline (Zoloft), 163, 304 Serum total cholesterol levels, by age, 92f Serum tumor markers, for ovarian tumors, 182t Sexual activity, by high school grade, 136f Sexual behavior, 136 by high school grade, 136f Sexual history, trigger questions for, 137 Sexual identity, 135 epidemiology of, 135 evaluation of, 137 major points of, 139 Sexual intercourse drug/alcohol usage and, by high school grade, 137f by high school grade, 136f Sexual orientation, 135 Sexuality, 135 Sexually transmitted infections (STIs), 195 major points of, 201 Sexual/reproductive health care, chronic health ­conditions and, 36 SHCN. See Special Health Care Needs SHH. See Structural hypogonadotropic hypogonadism Short stature, 59–60 Simvastatin, 94t Sinding-Larsen-Johansson syndrome, 129 Skin fold measurement, nutrition and, 21–22 Sleep, 110 architecture, 110–111 BEARS mnemonic for, 112 changes, total daily sleep and, 112f environmental factors affecting, 111 inadequate, 111 physiology, 111

Sleep (Continued) practices, developmental trends in, 112 regulation, two-process model of, 111f Sleep disorders epidemiology of, 111 evaluation of, 112 major points of, 116 management of, 112 pathophysiology of, 111 Sleep-disordered breathing obesity and, 66 spectrum of, 115f Slipped capital femoral epiphysis (SCFE), 122 radiograph of, 123f Social adaption, ADHD and, 261 Social context, of youth violence, 31 Social development, 3 Social phobia, 297–298 Somogyi effects, 85 Special Health Care Needs (SHCN), 39 Spectinomycin, 196 Spermatic cord, 140 Spermatocele, 140 Spermicides, as contraception, 230 Spine, lateral radiograph of, 122f Spironolactone, 79t, 102t, 163 Spondylolisthesis, 119 Spondylolysis, 119 asymptomatic, 120 radiograph of, 121f Sporadic hemiplegic migraine, 104 Sport-related injury, 15 Sports evaluation, pre-participation, 17 Sprain/tear of ACL, 120 of MCL, 126–127 of PCL, 127 Squamous metaplasia, 202 SSRIs. See Serotonin reuptake inhibitors State Bureau of Vocational Rehabilitation, 35 State statues, 46 Stavudine (D4T), 224t Step-one/step-two diets, for hypercholesterolemia, 93t STIs. See Sexually transmitted infections Strattera, 260t Stress fracture, of hip, 124, 124f Stroma, 146 Structural hypogonadotropic hypogonadism (SHH), 61 Substance abuse, CRAFFT screening test for, 273 Substance use. See also Alcohol use; Drug use;Tobacco use; specific substances discussion trigger questions on, 273 evaluation of, 271 major points on, 275 management of, 274

Index 329



Substance use (Continued) pathophysiology of, 271 protecting factors for, 270 risk factors for, 270 stages of, 273t Sufficient moderate physical activity, 14 Sufficient vigorous physical activity, 14 Suicide, 136–137 Sumatriptan, 106t Syphilis, 214 epidemiology of, 214 evaluation of, 216 latent, 215 management of, 216 pathophysiology of, 215 primary, 215 rate trends of, 215f secondary, 215 tertiary, 215 treatment guidelines for, 217t T T1DM. See Type 1 diabetes mellitus T2DM. See Type 2 diabetes mellitus TADS. See Treatment for Adolescents with Depression Study Tanner stages, 4, 4t, 5 of Black and White children, 4t of Mexican-American children, 4t Tazarotene, 100t TDF. See Tenofovir Tenofovir (TDF), 224t Teratoma, 176 Terazosin, 79t Tertiary syphilis, 215 Testicular torsion, 140 clinical finding of, 141t epidemiology of, 140 vs. epididymitis, 141t evaluation of, 141 management of, 141 pathophysiology of, 140 Testicular tumors, 144 epidemiology of, 144 evaluation of, 144 management of, 144 pathophysiology of, 144 Testicular volume, by pubertal stage, 6f Tetracycline, 100t, 101t Thelarche, 165 Thyroid-releasing hormone (TRH), 154 Tiredness, 110–111 TOA. See Tubo-ovarian abscess Tobacco use, 269. See also Substance use effects of, 272t Tolerance, 269

Topiramate (Topamax), 108t, 310 Torsion of testicular appendages, 140, 141 blue dot sign of, 142f epidemiology of, 141 evaluation of, 141 management of, 141 pathophysiology of, 141 Total daily dose, of insulin, 84–85, 86t Total daily sleep, sleep changes and, 112f Transgender, 135 Transsexual, 135 Trans-theoretical model of behavioral change (TTM), 11, 31, 32t, 273t Transverse vaginal septa, 155 Transvestite, 135 Treatment for Adolescents with Depression Study (TADS), 285 Treponema pallidum, 215 Tretinoin, 100t TRH. See Thyroid-releasing hormone Triamterene, 79t Trichloroacetic acid, 207t Trichomonas vaginalis, 186–187 Trichomoniasis, 186 diagnostic test characteristics for, 186t epidemiology of, 186–187 evaluation of, 187 management of, 187 pathophysiology of, 187 Triglycerides levels, for morbid obesity, 70t Triptans, 107 TTM. See Trans-theoretical model of behavioral change Tubo-ovarian abscess (TOA), 194 Tunica vaginalis, 140 Type 1 diabetes mellitus (T1DM), 82 alcohol use and, 87 driving and, 87 eating disorders and, 86–87 management of, 84 new therapies for, 86 pathophysiology of, 83 pregnancy and, 87 vs. T2DM, 84 Type 2 diabetes mellitus (T2DM), 82 lifestyle modification for, 86 management of, 86 obesity and, 66 oral pharmacotherapy for, 86 pathophysiology of, 83 screening for, 83, 84 vs. T1DM, 84 U Ultradian process, 110–111 Underweight, 65

330 Index

Unipolar depression, with BPD, risk factors for, 288 United States Preventive Services Task Force (USPSTF), 9 Urethritis, 184 Urinary symptoms, conditions associated with, 188 Urinary tract, 188 Urinary tract infection (UTI), 184, 188 epidemiology of, 188 evaluation of, 187 major points of, 192 management of, 189 pathophysiology of, 188 Urine leukocyte esterase, 184 Urine nitrate, 184 Uropathogens, 184 U.S. Preventive Services Task Force (USPSTF), 68, 118 U.S.Youth Risk Behavior Survey (YRBS), 136 User, 269 USPSTF. See United States Preventive Services Task Force; U.S. Preventive Services Task Force Uterus, congenital anomalies of, 180 UTI. See Urinary tract infection V Vagina, congenital anomalies of, 180 Vaginal discharge, causes of, 185 Vaginitis, 184, 185 Valium, effects of, 272t Valproate, 108t, 309 Varicella-zoster virus (VZV), HIV and, 226 Varicocele, 140, 143 classification of, 144t epidemiology of, 143 evaluation of, 144 left-sided, 143f management of, 144 pathophysiology of, 143 VDRL. See Venereal Disease Research Laboratory Vegetarianism, 26 types of, 26t Venereal Disease Research Laboratory (VDRL), 216 Venlafaxine (Effexor XR), 163, 284t, 301, 305 Violence. See Youth violence Violence-related injury, visit for, 30 Viral protein formation, of HIV, 221–222 Virilization, 166 Vitamin D, 23 Vitamins, 23 von Willebrand disease, DUB and, 158 Vulva, 184 aphthous ulcers on, 191, 192f normal anatomy of, 190f skin lichenification of, 191f

Vulvar abnormalities, 189 developmental, 189 Vulvar itching/irritation, 189, 191t Vulvar lesions, 191, 192f VZV. See Varicella-zoster virus W Waist circumference, nutrition and, 21 Waist-hip ratio, nutrition and, 21 Wet mount, 184–185 of candidiasis, 186f White-coat hypertension, 73 WHO. See World Health Organization Withdrawal, 269 Wolffian duct remnants, 179 epidemiology of, 179 evaluation of, 180 laparoscopic view of, 180f management of, 180 pathophysiology of, 179 radiograph of, 180f Wolffian ducts, 176 World Health Organization (WHO), 248 classification of function, 249f X Xanax, effects of, 272t Y Youth Risk Behavior Survey (YRBS), 269–270 Youth violence annual comprehensive visit on, 29 clinical setting approaches to, 28 decision tree of, 33f evaluation of, 29 fighting threshold for, 31 interim visit on, 30 intervention for, 31 positive coping strategies against, 30f protective factors for, 29 readiness for change and, 31 resilience-based prevention for, 28 risk factors for, 29 social context of, 31 YRBS. See U.S.Youth Risk Behavior Survey;Youth Risk Behavior Survey Z Zalcitabine (DDC), 224t Zidovudine (AZT), 224t Zinc, 23 Ziprasidone (Geodon), 288–289, 307 Zolmitriptan, 106t